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TDMS Study 05079-02 Pathology Tables

NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  14807966

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|             
                                           | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|             
    CONTOL                                 | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +     +  +  M  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  A  +  +  +  +  +  +  +     A  +  M  +  +  +  I     +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  +  +  +     A  +  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  A  +  +  +  +  +  +  A     A  +  A  +  +  +  +     +  A  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  M  +  +  +  +  +  +  +  +     A  +  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  M  +  +  +  +     M  +  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  A  +  +  +  +  +  +  +     A  +  A  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  A  +  +  M  +  M  M  A     A  M  A  +  +  +  +     +  +  +     +|             
      Ulcer, Focal                         |                                                                          |             
      Mucosa, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  +  +  +  +  +  +  A     A  +  A  +  +  +  +     +  +  +     +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mucosa, Atrophy                      |       2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  +  +  +  +  +  +  +     A  +  A  +  +  +  +     +  A  +     +|             
      Mucosa, Atrophy                      |       2                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Focal Cellular Change                |                                                                   X      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Focal                  |                                        2                                 |             
      Necrosis, Focal                      |                                                                          |             
      Serosa, Inflammation, Suppurative    |                                     2                                    |             
      Sinusoid, Inflammation               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +     A  +  A  +  +  +  +     +  +  +     +|             
      Acinus, Hyperplasia, Focal           |                                        1                                 |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
      Hyperplasia, Focal, Squamous         | 2                                                                        |             
      Ulcer, Focal                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
      Ulcer, Focal                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Myocardium, Degeneration, Focal      |                                                                          |             
      Myocardium, Mineralization, Focal    |                                                                          |             
      Pericardium, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|             
                                           | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|             
    CONTOL                                 | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Capsule, Inflammation, Suppurative   |                                     3                                    |             
      Corticomedullary Junction, Hemorrhage| 2                                                                        |             
      Spindle Cell, Hyperplasia            | 3  4  4  3  2  2  3  4  3  3  2     3  2  2  3  3  2  4     4  2  3     3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Cyst                                 |                                                 X                        |             
      Vacuolization Cytoplasmic, Focal     |                   2                                2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  +  +  +  +     M  +  +  +  +  +  +     +  +  +     +|             
      Hyperplasia, Focal                   |                                                       1                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  M  +  +  +  +  +  +  +     A  M  A  +  I  +  I     +  +  I     I|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  M  I  M  +  +  +  +  +     +  +  +  M  +  +  M     +  +  I     +|             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +     M  +  M  +  +  +  +     +  +  +     +|             
      Cyst                                 |                         X                                                |             
      Hemorrhage, Focal                    |                2                                            2            |             
      Hyperplasia, Focal                   |                                              2                    2      |             
      Pigmentation, Lipofuscin             |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Cyst                                 |       X                                                                  |             
      C-Cell, Hyperplasia                  |                         1                                                |             
      Follicular Cell, Hyperplasia         |       2           3  1  2              1                                1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                   +      |             
      Thrombosis, Chronic                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  I  +  I     +  +  +  M  +  +  +     M  +  +     +|             
      Abscess                              |                                     4                                    |             
      Cyst                                 |                                        X                          X      |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    2  3  1  3  4  4  2  3  1  1        2     3  3  3  2     3     4     3|             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  A     A  +  A  +  +  +  +     +  +  +     +|             
      Hyperplasia                          |          3                                                               |             
      Myelofibrosis                        |    2  1     2  3  1  2  2  2                       2  2           1     3|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Iliac, Inflammation                  |                                     4                                    |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|             
                                           | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|             
    CONTOL                                 | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Inflammation                  |                                     4                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  I  +  M     +  +  M  +  +  +  +     +  +  +     I|             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Acute                  |                                     4                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  M  +  +  M  +  +     +  +  +  +  M  M  +     +  +  +     +|             
      Depletion Lymphoid                   |                                           3                              |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Plasma Cell             |       4                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  +  +  M  +  M  +  M  M     M  M  M  M  M  +  M     M  +  M     M|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  M  +  +  +  +  M  +  +  M     M  +  M  +  +  +  +     +  +  +     +|             
      Infiltration Cellular, Mixed Cell    |    2                                                                     |             
      Follicular, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     3                                    |             
      Hyperplasia, Lymphoid                |                   2  3  3                          2                     |             
      Inflammation, Suppurative            |                                                                          |             
      Capsule, Inflammation, Suppurative   |                                     2                                    |             
      Lymphoid Follicle, Depletion Lymphoid|                                                                          |             
      Lymphoid Follicle, Necrosis          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +     +  +  +     +|             
      Cyst                                 | X                                                                        |             
      Necrosis                             |                                                                2         |             
      Cortex, Depletion Lymphoid           | 3                             2     2                             3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  I     +  +  A  +  +  I  +     +  +  +     +|             
      Edema                                |                                                                3         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Alopecia                             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Periosteum, Femur, Proliferation     |                                                                          |             
          Connective Tissue                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Mineralization, Focal                |    2  1  2        2     1  2  2     1  1  1  2     2  1     1  1  1     2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  I  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 5| 6| 5| 7| 5| 7| 7| 7| 7| 5| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 8| 2| 2| 0| 2| 2| 2| 2| 3| 3| 4| 6| 0| 3| 0| 3| 3| 3| 3| 9| 3| 9| 3| 4| 3|             
                                           | 7| 9| 9| 9| 9| 9| 9| 9| 3| 0| 4| 9| 5| 0| 6| 0| 0| 0| 0| 0| 0| 2| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 9| 0| 1| 1| 1| 1| 1| 2| 4| 4| 4| 4| 4| 4| 4| 5| 6| 7|             
    CONTOL                                 | 6| 7| 1| 2| 4| 6| 9| 0| 9| 1| 5| 6| 7| 8| 0| 0| 1| 2| 3| 4| 5| 6| 0| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Macrophage              |             3                                                            |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Pleura, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Cytoplasmic Alteration, Focal        |    2        2  1  1  1     1                 2  1  1  2     1  2  1     1|             
      Developmental Malformation           |    X                                                                     |             
      Erosion, Focal                       |                                                    1  1                  |             
      Inflammation, Acute                  |                                              1     1  1                  |             
      Ulcer, Focal                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  A  +  +  +  +  +  +  +     M  +  A  +  +  +  +     +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +|             
      Infarct                              |                                                       3                  |             
      Inflammation, Focal                  |                                     2                                    |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Nephropathy, Chronic                 |                                                                          |             
      Capsule, Inflammation, Suppurative   |                                     2                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +     +  +  +     +|             
      Submucosa, Hyperplasia, Lymphoid     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3|            |
                                           | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3|      A     |
    CONTOL                                 | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  M  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  A  +  +  +  A  A  M  +  +  +  A  +  +     A  +  +  +  A  A  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  A  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  A  +  +  +  +  A  +  +     +  +  +  +  A  A  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +     +  +  +  +  A  A  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  M  M  +  +  M  +  +  M  +  +  +  A  +  +     M  +  +  +  A  +  +  +|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  A  +  +  +  +  A  +  +  +  +  A  +  +     A  +  +  +  A  A  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  A  +  +  +  A  A  +  M  M  +  A  +  +     A  +  +  +  A  A  +  +|  27        |
      Ulcer, Focal                         |                            4                                             |      1  4.0|
      Mucosa, Atrophy                      |                                           2                 3            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  A  +  +  +  +  A  +  +  +  A  A  +  +     A  +  +  +  A  A  +  +|  33        |
      Hyperplasia, Lymphoid                |       2                                                                  |      1  2.0|
      Mucosa, Atrophy                      |                                           2                 3        2   |      4  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  M  A  +  +  +  +  A  +  +  +  +  A  +  +     A  +  +  +  A  A  +  +|  33        |
      Mucosa, Atrophy                      |                                           2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Focal Cellular Change                |                                                       X                  |      2     |
      Hematopoietic Cell Proliferation     |                                                                         3|      1  3.0|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Necrosis, Focal                      |                            1                                             |      1  1.0|
      Serosa, Inflammation, Suppurative    |          3              2                                         3      |      4  2.5|
      Sinusoid, Inflammation               |                         2                                         3      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     I  +  +  +  +  A  +  +|  42        |
      Acinus, Hyperplasia, Focal           |                                                                          |      1  1.0|
      Serosa, Inflammation, Suppurative    |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  45        |
      Serosa, Inflammation, Suppurative    |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  45        |
      Hyperplasia, Focal, Squamous         |                                                             3            |      2  2.5|
      Ulcer, Focal                         |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  45        |
      Ulcer, Focal                         |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Myocardium, Degeneration, Focal      |                                                                         1|      1  1.0|
      Myocardium, Mineralization, Focal    |                                                                         1|      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3|            |
                                           | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3|      A     |
    CONTOL                                 | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Pericardium, Inflammation,           |                                                                          |            |
          Suppurative                      |          1                                                               |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Capsule, Inflammation, Suppurative   |          3              2                                         3      |      4  2.8|
      Corticomedullary Junction, Hemorrhage|          4                                                               |      2  3.0|
      Spindle Cell, Hyperplasia            | 3  3  2  3  3  3  3  1  3  3  4  2  3  3  2  3     3  4  2  3  1  3  4  2|     46  2.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                   X                                                      |      2     |
      Vacuolization Cytoplasmic, Focal     |                   2                                                      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +     I  +  +  +  +  +  +  M|  41        |
      Hyperplasia, Focal                   |                               2                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  M  I  I  I  +  I  +  I  +  +  +  +  I  M  M     M  I  +  +  +  M  M  +|  25        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  I  +  M  M  M  +  M  +  M  +  +  I  +  +  M     M  +  M  M  M  +  M  +|  23        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +     +  +  +  +  M  +  +  +|  42        |
      Cyst                                 | X                                                                        |      2     |
      Hemorrhage, Focal                    |                                                                          |      2  2.0|
      Hyperplasia, Focal                   |                                                                          |      2  2.0|
      Pigmentation, Lipofuscin             |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +     +  +  +  +  A  +  +  +|  43        |
      Cyst                                 |                                                             X            |      2     |
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                   1                          2              2            |      9  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +           +                                         +                  |   4        |
      Thrombosis, Chronic                  | X                                                                        |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  M  +  +  +  +  +  +  +  M  +  +  I  +  +     M  +  +  +  +  +  +  +|  38        |
      Abscess                              |          4              4                                         4      |      4  4.0|
      Cyst                                 |    X              X                                   X     X            |      6     |
      Thrombosis                           |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +     +  +  +  +  M  +  +  +|  44        |
      Thrombosis                           |                                                             X            |      1     |
      Endometrium, Hyperplasia, Cystic     | 4     2  2  2  4  3  3        3  2  1        4     2  3  3  4        3   |     34  2.7|
      Mucosa, Inflammation, Suppurative    |          4              4                                         1      |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3|            |
                                           | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3|      A     |
    CONTOL                                 | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Serosa, Inflammation, Suppurative    |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +|  41        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Myelofibrosis                        | 2     2     2  1  1  1        3  2  2  1     3     1  2  2  2        4   |     28  1.9|
      Myeloid Cell, Hyperplasia            |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Iliac, Inflammation                  |                                                                          |      1  4.0|
      Pancreatic, Hyperplasia, Lymphoid    |                            4                                             |      1  4.0|
      Renal, Inflammation                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +|  38        |
      Infiltration Cellular, Mixed Cell    |                                        2                                 |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  M  M  +  +  M  +     +  +  M  +  +  M  +  +|  35        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                2         |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  M  M  M  +  +  M  M  M  M  M  M  M     M  M  M  M  M  +  M  +|  13        |
      Hyperplasia, Histiocytic             |                         2                                                |      1  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +     +  +  +  M  M  +  M  +|  35        |
      Infiltration Cellular, Mixed Cell    | 3                 2                                3              2      |      5  2.4|
      Follicular, Necrosis                 |    2                 2  3                                                |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  45        |
      Congestion                           |                                  3                                3      |      2  3.0|
      Hematopoietic Cell Proliferation     | 2        4              4  3           3  3                       2      |      8  3.0|
      Hyperplasia, Lymphoid                |          2                                                               |      5  2.4|
      Inflammation, Suppurative            |                         2                                         4      |      2  3.0|
      Capsule, Inflammation, Suppurative   |                         1                                                |      2  1.5|
      Lymphoid Follicle, Depletion Lymphoid|                                  2                             3         |      2  2.5|
      Lymphoid Follicle, Necrosis          |          2                                                        2      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +     +  +  +  +  M  +  I  +|  40        |
      Cyst                                 |                                                             X            |      2     |
      Necrosis                             |                         2                                         1      |      3  1.7|
      Cortex, Depletion Lymphoid           |    3                    3                          2              1      |      8  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  A  +  +  +|  41        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3|            |
                                           | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3|      A     |
    CONTOL                                 | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Alopecia                             |                                        X                                 |      2     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Periosteum, Femur, Proliferation     |                                                                          |            |
          Connective Tissue                |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Mineralization, Focal                | 1  2  2  2  1  2     2  2  1  2  2  1  2  1  1     2  1     1        2   |     36  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +     +  +  +  +  +  +  +  +|  42        |
      Inflammation, Acute                  |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Congestion                           |    3                                                                     |      1  3.0|
      Hyperplasia, Macrophage              |                2                                                         |      2  2.5|
      Metaplasia, Focal, Osseous           |                                                             1            |      1  1.0|
      Pleura, Inflammation, Suppurative    |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Cytoplasmic Alteration, Focal        | 2           1  2  1     1     1  2  2  2     1     2  1  1  2        1   |     29  1.4|
      Developmental Malformation           |                                                                          |      1     |
      Erosion, Focal                       | 1                                                                        |      3  1.0|
      Inflammation, Acute                  | 1                                         1                             1|      6  1.0|
      Ulcer, Focal                         |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M     +  +  +  +  A  A  +  +|  40        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                         +|   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|  46        |
      Infarct                              |                                                                          |      1  3.0|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Metaplasia, Focal, Osseous           |                                                             2            |      1  2.0|
      Nephropathy, Chronic                 |                            1                                             |      1  1.0|
      Capsule, Inflammation, Suppurative   |          1              2                                                |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 0| 4| 7| 7|            |
                             DAY ON TEST   | 3| 9| 3| 5| 3| 3| 3| 2| 8| 2| 3| 3| 3| 4| 8| 3| 4| 8| 3| 3| 3| 3| 6| 3| 3|            |
                                           | 1| 8| 1| 2| 1| 1| 3| 3| 3| 6| 2| 2| 2| 1| 6| 2| 7| 0| 2| 3| 3| 0| 5| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 8| 9| 9| 0| 0| 0| 0| 0| 0| 0| 2| 2| 2| 3| 3| 3| 3| 3| 3|      A     |
    CONTOL                                 | 1| 3| 4| 5| 8| 9| 0| 6| 7| 0| 1| 2| 4| 5| 7| 9| 7| 8| 9| 0| 1| 3| 4| 8| 9|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +|  44        |
      Submucosa, Hyperplasia, Lymphoid     |                   3                                                      |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|             
                                           | 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|             
    6 MG/M3                                | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  A  +  +  +  +  A  +     +  M  A  A  A  +  +  A  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +  A  +     +  +  A  A  A  +  +  A  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  A  +  +  +  +  A  +     +  A  A  A  A  +  +  A  A  A  +  +  +  +|             
      Serosa, Inflammation, Suppurative    |    3                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  A  +     +  A  A  A  A  +  +  A  +  A  +  +  +  +|             
      Serosa, Inflammation, Suppurative    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  M  +  +  +  +  M  +  A  +     +  +  M  A  A  +  +  A  A  A  M  I  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  A  +  +  +  +  A  +     +  A  A  A  A  +  +  A  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  A  +  +  +  +  A  +     +  A  A  A  A  +  +  A  A  A  +  +  +  +|             
      Mucosa, Atrophy                      |       3                                                        2        2|             
      Serosa, Inflammation, Suppurative    |    1                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  +  +  +  +  A  +     +  A  A  A  A  +  +  A  A  A  A  +  +  +|             
      Hyperplasia, Lymphoid                |    4                                                                     |             
      Mucosa, Atrophy                      |       3     2                                                            |             
      Serosa, Inflammation, Suppurative    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  +  +  +  +  A  +     +  A  A  A  A  +  +  A  A  A  +  +  +  +|             
      Mucosa, Atrophy                      |       3                                                        2        2|             
      Serosa, Inflammation, Suppurative    |    3                                                                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Focal Cellular Change                |                X     X                                                   |             
      Hematopoietic Cell Proliferation     |          1                                                               |             
      Inflammation, Focal                  |                            1                                             |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation, Focal, Hemosiderin     |                                                                          |             
      Centrilobular, Degeneration          |                                                                          |             
      Centrilobular, Necrosis, Coagulative |                                                 2                        |             
      Serosa, Inflammation, Suppurative    |    3     2              3                    3              2            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  I  +  +  +  +  +  A  +     +  +  I  A  A  +  +  M  +  A  +  +  +  +|             
      Serosa, Inflammation, Suppurative    |    3     4                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
      Serosa, Inflammation, Suppurative    |    3                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |             3                                                     2      |             
      Ulcer, Focal                         |             2                                                     2      |             
      Glandular, Inflammation, Focal       |                                                          2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  A  +     +  +  +  A  +  +  +  A  +  A  +  +  +  +|             
      Ulcer, Focal                         |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|             
                                           | 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|             
    6 MG/M3                                | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Focal      |                         1                                                |             
      Pericardium, Inflammation,           |                                                                          |             
          Suppurative                      |    1                    2                                                |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
      Capsule, Inflammation, Suppurative   |    2     3              2                    2        3                  |             
      Corticomedullary Junction, Hemorrhage|                                                       2                  |             
      Spindle Cell, Hyperplasia            | 3  3  3  3  4  2  2  3  2  3     3  1  3     3  3  3  3  3     2  3  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +  +  M  A  +  +  +  +  +  A  +  +  +  +|             
      Cyst                                 |             X                                            X               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  I  I  I  +  M  +  A  +     I  I  M  A  M  +  M  M  I  A  +  +  +  I|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  I  I  +  M  M     +  +  +  M  M  +  M  M  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +     +  +  I  M  I  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |       1  2  2  3                                         1        3     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  M  M  +  +     +  +  M  A  +  +  +  +  +  +  +  +  M  +|             
      Abscess                              |    4     4              4                    4        4     4            |             
      Cyst                                 |             X  X                 X              X        X        X      |             
      Thrombosis                           |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |       2  1  3  2  3  4     2     2              2  1     1  1  2  1      |             
      Mucosa, Inflammation, Suppurative    |    1     1                                   2        1                  |             
      Serosa, Inflammation, Suppurative    |                                              2        3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  A  +  A  +  +  +  +|             
      Hyperplasia                          |                   3                                               2     2|             
      Myelofibrosis                        |       3     1  1  4  4           3              1  1     3     1  1     1|             
      Myeloid Cell, Hyperplasia            |          3                 4        3        3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | A  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal, Hyperplasia, Lymphoid         |                                              4                           |             
      Renal, Inflammation                  |          4                                                               |             
      Renal, Follicular, Necrosis          |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  I  M  +  I  +  +  +  +     +  M  +  +  +  +  M  M  +  +  +  +  I  +|             
      Hyperplasia, Histiocytic             |    1        2        2           2           1           2  2           2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|             
                                           | 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|             
    6 MG/M3                                | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |             2        3  3        1           2              3           2|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  M  +  +  +  M  +     +  +  +  +  M  +  M  M  +  M  +  +  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                           2                              |             
      Inflammation                         |                                                                          |             
      Follicular, Necrosis                 |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  M  +  M  M  M  +     M  M  +  M  M  +  +  +  I  M  +  +  M  M|             
      Hyperplasia, Histiocytic             |                            1                                             |             
      Hyperplasia, Lymphoid                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  A  +     I  M  +  A  +  M  +  A  +  A  +  M  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Infiltration Cellular, Mixed Cell    |       3                    2                                             |             
      Inflammation                         |          4                                                               |             
      Follicular, Necrosis                 |    3  1  2                 2                 2                          2|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  A  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3     2        2     3                    3        3                  |             
      Hyperplasia, Lymphoid                |                   2                          3     2                    2|             
      Capsule, Inflammation, Suppurative   |    4                    2                                                |             
      Lymphoid Follicle, Depletion Lymphoid|                                     3                                    |             
      Lymphoid Follicle, Necrosis          |          2                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  +  +  +  +  +     +  M  +  M  I  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Plasma Cell             |    3                                                                     |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                       2     3            |             
      Cortex, Depletion Lymphoid           | 2  2  3                 3                             3  3  2            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  I  +  +  +  +  +  +  I  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |       X                 X                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Mineralization, Focal                |       1     1     2        2           2  2  2  1  2  2  2  2  2  2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 7| 0| 6| 6| 6| 7| 7| 6| 6| 7| 7| 7| 0| 7|             
                             DAY ON TEST   | 2| 5| 1| 1| 2| 2| 2| 3| 0| 3| 2| 3| 9| 2| 7| 9| 3| 3| 4| 9| 1| 3| 3| 9| 2|             
                                           | 2| 9| 2| 8| 9| 9| 9| 3| 0| 0| 2| 0| 2| 8| 6| 9| 0| 0| 1| 2| 4| 1| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 7| 7| 8| 8| 8| 8| 8| 9| 0|             
    6 MG/M3                                | 6| 9| 0| 2| 4| 9| 0| 7| 0| 2| 3| 4| 5| 6| 8| 0| 6| 8| 1| 3| 5| 7| 9| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  A  +  +  +  +  A  +     +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           3              2               |             
      Hyperplasia, Macrophage              | 1  1  2  2  1  1  2  2  2  2     2     1     2  2  1  1  2  2  2  1     2|             
      Inflammation, Chronic Active         |    1              1  2     2     2           1  2  1     1     1        1|             
      Perivascular, Inflammation,          |                                                                          |             
          Suppurative                      |                         1                                   1            |             
      Pleura, Inflammation, Suppurative    |          1              3                                                |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  A  +     +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Cytoplasmic Alteration, Focal        | 1  2  2  3  4  1  4  4     3     2     2        2  3     2     3  2     3|             
      Inflammation, Acute                  |                                  1  2                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  A  +  +  +  +  A  +     +  +  A  M  +  +  +  A  +  A  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Nephropathy, Chronic                 |                                                                          |             
      Capsule, Inflammation, Suppurative   |    2     3              2                    1        1                  |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +     +  A  +  A  +  +  +  A  +  A  +  +  +  +|             
      Serosa, Inflammation, Suppurative    |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3|            |
                                           | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8|      A     |
    6 MG/M3                                | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  M  A  +  A  A  +  M  A  +  +  A  +  +  +  +  A  +  A  +  +  +|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  A  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  A  A  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  A  +  +  A  +  A  A  +  +  A  +  +  +  +  A  +  A  A  +  +|  30        |
      Serosa, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  A  +  +  A  +  A  A  +  +  +  +  +  +  +  +  +  A  A  +  +|  34        |
      Serosa, Inflammation, Suppurative    |                      2                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  A  A  +  M  A  +  A  A  +  +  M  I  +  +  M  +  +  A  M  +  M|  23        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  A  +  +  A  +  A  A  +  +  A  +  +  +  +  A  +  A  A  +  +|  30        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  A  A  +  +  A  +  A  A  +  I  A  +  +  +  +  A  +  A  A  M  M|  26        |
      Mucosa, Atrophy                      |                   2  2                       3                           |      6  2.3|
      Serosa, Inflammation, Suppurative    |                      3                                                   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  A  A  +  +  A  +  A  A  +  +  A  +  +  +  +  A  +  A  A  +  +|  28        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Mucosa, Atrophy                      | 2                 2        3                 3                           |      6  2.5|
      Serosa, Inflammation, Suppurative    |                      3                                                   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  A  +  +  A  +  A  A  +  +  A  +  +  M  +  A  +  A  A  +  +|  29        |
      Mucosa, Atrophy                      | 2     2           2                          3                           |      7  2.3|
      Serosa, Inflammation, Suppurative    |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Eosinophilic Focus                   |                                                                      X   |      1     |
      Fibrosis, Focal                      |                                                          1               |      1  1.0|
      Focal Cellular Change                |                                                       X                  |      3     |
      Hematopoietic Cell Proliferation     |                                                                   2      |      2  1.5|
      Inflammation, Focal                  |                                                             1            |      2  1.0|
      Necrosis, Focal                      |                         1  1                                             |      2  1.0|
      Pigmentation, Focal, Hemosiderin     |          3                                                               |      1  3.0|
      Centrilobular, Degeneration          |                   2                                                      |      1  2.0|
      Centrilobular, Necrosis, Coagulative |                                                                          |      1  2.0|
      Serosa, Inflammation, Suppurative    |                                                                2  4      |      7  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Serosa, Inflammation, Suppurative    |                      4                                         2  4      |      5  3.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Serosa, Inflammation, Suppurative    |                                                                   2      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Focal, Squamous         |                               2  2                                       |      4  2.3|
      Ulcer, Focal                         |                                  1                                       |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3|            |
                                           | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8|      A     |
    6 MG/M3                                | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Glandular, Inflammation, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +|  40        |
      Ulcer, Focal                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myocardium, Inflammation, Focal      |                                                                          |      1  1.0|
      Pericardium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Capsule, Inflammation, Suppurative   |                      2                                         2         |      7  2.3|
      Corticomedullary Junction, Hemorrhage|    2           2                                                         |      3  2.0|
      Spindle Cell, Hyperplasia            | 3  3  3  2     1  3  3  2  3  2  3  3  3  3  2  4  3  3  3  3  3  3  4  2|     46  2.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                                                   X      |      3     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  I  A  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | I  +  I  +  A  M  M  M  +  I  M  I  I  +  I  +  +  +  +  +  +  M  I  +  +|  21        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  A  I  I  +  +  M  I  +  M  I  M  +  M  M  +  M  I  M  +  M  +|  19        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicular Cell, Hyperplasia         |       1  1              1                                            2  2|     12  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Abscess                              |    4                 4                                         4  4      |     10  4.0|
      Cyst                                 |          X        X                          X  X           X            |     11     |
      Thrombosis                           |          X                                                               |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Metaplasia, Squamous                 |                                        3                                 |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 1     3           2  3     4     1  1  4  1  2  1  4  2     2        2  3|     30  2.1|
      Mucosa, Inflammation, Suppurative    |    1                                                           1  1      |      7  1.1|
      Serosa, Inflammation, Suppurative    |                      1                                            3      |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3|            |
                                           | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8|      A     |
    6 MG/M3                                | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +|  44        |
      Hyperplasia                          |                                                                         3|      4  2.5|
      Myelofibrosis                        | 4                 2        3        2  2  1  1  2  2        2        2   |     23  2.0|
      Myeloid Cell, Hyperplasia            |    2                 4                                                   |      6  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Renal, Hyperplasia, Lymphoid         |                      4                                                   |      2  4.0|
      Renal, Inflammation                  |                                                                          |      1  4.0|
      Renal, Follicular, Necrosis          |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  I  +  +  +  +  +  +  M  +  +|  37        |
      Hyperplasia, Histiocytic             |    1  2  1        2  1     1     2  1  2        1  2  2  1  2  1     1  2|     25  1.6|
      Hyperplasia, Lymphoid                | 1  3                                2  1        2     3     1        2  2|     16  2.1|
      Inflammation, Acute                  |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  38        |
      Hyperplasia, Lymphoid                |                                                                   4      |      1  4.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
      Inflammation                         |                                                                   3      |      1  3.0|
      Follicular, Necrosis                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  +  +  M  +  M  +  M  +  +  M  M  M  M  M  M  +  M  M  M  M  M  M|  17        |
      Hyperplasia, Histiocytic             |       1     3                                                            |      3  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  I  A  M  +  +  +  +  M  +  +  M  +  +  +  +  M  M  +  +  M  +  +|  32        |
      Depletion Lymphoid                   |                                                                2         |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                3         |      1  3.0|
      Hyperplasia, Lymphoid                | 2                                                                        |      2  2.0|
      Infiltration Cellular, Mixed Cell    |                   1  4  2                                                |      5  2.4|
      Inflammation                         |                                     3                                    |      2  3.5|
      Follicular, Necrosis                 |    1                 2              2           1  1        1            |     12  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hematopoietic Cell Proliferation     |          3           3  2                                      3  4     2|     12  2.8|
      Hyperplasia, Lymphoid                | 2                 2              2     2                                 |      8  2.1|
      Capsule, Inflammation, Suppurative   |                                                                   4      |      3  3.3|
      Lymphoid Follicle, Depletion Lymphoid|                      2                                         3         |      3  2.7|
      Lymphoid Follicle, Necrosis          |                      2                                         2  1      |      4  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  M  +  +  +  +  M  +  +  +  I  +  +  +  +  M  +  +  +  +  +|  41        |
      Cyst                                 |                                                    X                    X|      2     |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                   4      |      1  4.0|
      Necrosis                             |                      2                                         2  2      |      5  2.2|
      Cortex, Depletion Lymphoid           |                   2  2  2                    2                 2         |     12  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3|            |
                                           | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8|      A     |
    6 MG/M3                                | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Alopecia                             |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydrocephalus                        |                                           3        3                     |      2  3.0|
      Mineralization, Focal                | 2  1     1  1        2        2  2  2  2  2  1  2  1  2  2  2     1  2  2|     33  1.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                3                                                         |      3  2.7|
      Hyperplasia, Macrophage              | 2  3  2  1  1     2  2  1  2  2  2  1  1  1  2  1  2  2  1  1  1  1  2  2|     45  1.6|
      Inflammation, Chronic Active         | 2  2  1  1                 2  1  1     1     1  1  2  2              1  1|     25  1.4|
      Perivascular, Inflammation,          |                                                                          |            |
          Suppurative                      |                                                                   3      |      3  1.7|
      Pleura, Inflammation, Suppurative    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cytoplasmic Alteration, Focal        | 4     2  3        2  1  4  2  1  4  2  3  1  2  3  2  3  2  3        2  2|     37  2.5|
      Inflammation, Acute                  |    2                          1                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  M  M  M|  37        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                      +                                                   |   1        |
      Inflammation, Suppurative            |                      4                                                   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +              +                                                   |   2        |
      Inflammation, Suppurative            |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Casts Protein                        |                               2                                         2|      2  2.0|
      Infarct                              |                                     1                                    |      1  1.0|
      Inflammation, Focal                  |                      1                                                   |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 4| 0| 7| 6| 6| 7| 6| 7| 7| 7| 5| 5| 7| 7| 7| 6| 7| 5| 5| 7| 7|            |
                             DAY ON TEST   | 3| 6| 3| 3| 9| 2| 0| 2| 4| 3| 8| 0| 3| 3| 3| 5| 3| 3| 3| 7| 3| 6| 4| 3| 3|            |
                                           | 0| 5| 1| 1| 1| 0| 9| 1| 5| 1| 6| 9| 2| 2| 4| 4| 2| 2| 2| 8| 2| 4| 8| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 1| 1| 1| 2| 3| 3| 3| 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 8|      A     |
    6 MG/M3                                | 7| 8| 9| 1| 5| 7| 8| 0| 6| 8| 9| 0| 4| 5| 7| 8| 6| 8| 9| 1| 2| 5| 6| 8| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy, Chronic                 |                                                                         2|      1  2.0|
      Capsule, Inflammation, Suppurative   |                                                                   2      |      6  1.8|
      Renal Tubule, Hyperplasia, Focal     |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  41        |
      Serosa, Inflammation, Suppurative    |                      1                                            3      |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|             
                                           | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|             
    18 MG/M3                               | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  M  A  A  A  M  +  A  A  +  A  +  A  +  A  +  M  +  M  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  A  A  +  +  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  A  A  +  A  A  A  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Lymphoid                |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  A  A  +  A  A  A  +  A  A  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  A  M  +  +  A  A  +  A  M  +  +  +  +  +  M  M  +  +  +  M  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  A  A  +  A  A  A  +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A  A  +  A  A  A  M  A  A  +  A  M  A  +  M  +  +  +  +  M  +  A  +  +|             
      Mucosa, Atrophy                      |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  A  A  A  A  A  +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Mucosa, Atrophy                      |                                                          2               |             
      Peyer's Patch, Necrosis              |                                  2                                       |             
      Serosa, Inflammation, Suppurative    |                                                                      2   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  A  +  A  A  A  +  A  A  +  A  +  A  +  A  +  +  +  +  +  +  A  +  +|             
      Mucosa, Atrophy                      |                                                                          |             
      Serosa, Inflammation, Suppurative    |                                                                      2   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Inflammation, Focal                  |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Serosa, Inflammation, Suppurative    |                         3  3                                         3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  A  +  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Focal                  |                      1                                                   |             
      Serosa, Inflammation, Suppurative    |                         3  2                                         2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Granulomatous  |                      1                                                   |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Mast Cell        |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                    3                     |             
      Glandular, Inflammation, Focal       |                                           1        2                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pericardium, Inflammation,           |                                                                          |             
          Suppurative                      |                            1                 3                       2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|             
                                           | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|             
    18 MG/M3                               | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Inflammation, Suppurative   |                         2  3                                         1   |             
      Corticomedullary Junction, Hemorrhage|                                                                          |             
      Spindle Cell, Hyperplasia            |    1  2  1     1  1  3  3  3  3  3  2  3  3  2  2  3  2  3  2  3  3  3  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | I  I  +  M  +  +  I  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  I  M  A  M  +  +  M  I  +  M  I  I  M  +  I  +  I  +  I  A  I  I|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  +  M  M  M  I  +  I  +  +  M  +  +  +  +  +  I  M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                         1                          2                     |             
      C-Cell, Hyperplasia                  |                                                                         1|             
      Follicular Cell, Hyperplasia         |                            1              3        2        1            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                         4  4                 4                       4   |             
      Cyst                                 |                               X  X                 X     X        X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Focal, Histiocytic      |                                                       2                  |             
      Endometrium, Hyperplasia, Cystic     |       1              1  1     4  2  3  1  3  1  2  1     2  1     1  2  3|             
      Mucosa, Inflammation, Suppurative    |                            1                 2                       1   |             
      Serosa, Inflammation, Suppurative    |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
      Hyperplasia                          |                                                       2           3      |             
      Myelofibrosis                        |                      1        3  1  2  1  2     1  1     3  3  2  3     2|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Inflammation                  |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                            3                                             |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Mixed Cell                      |                                                                          |             
      Pancreatic, Follicular, Necrosis     |                            2                                             |             
      Renal, Hyperplasia, Lymphoid         |                         4                                                |             
      Renal, Infiltration Cellular, Mixed  |                                                                          |             
          Cell                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|             
                                           | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|             
    18 MG/M3                               | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Renal, Inflammation                  |                                                                          |             
      Renal, Follicular, Necrosis          |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  M  I  +  M  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                      3  3  3  4  3  3  4  1  2  2  2  3  2  3  3     3  4|             
      Hyperplasia, Lymphoid                |                                  2  2        3     2        2           3|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  M  +  M  +  +  +  M  +  +  +  +  +  +  M  +  I  +  +  M  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  M  M  M  M  +  +  M  M  M  M  M  +  M  M  +  M  M  +  +  M  M|             
      Hyperplasia, Histiocytic             |                         2  4                                             |             
      Hyperplasia, Lymphoid                |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  A  A  +  M  M  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                         2                                                |             
      Hematocyst                           |                                                                         X|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                      3   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                            3                                             |             
      Inflammation                         |                                                                          |             
      Follicular, Necrosis                 |                         3                 1  2                 3         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      3  4  4                 3        3              4   |             
      Hyperplasia, Lymphoid                |                                              2     2                     |             
      Inflammation, Suppurative            |                                                                          |             
      Capsule, Inflammation, Suppurative   |                                                                      2   |             
      Lymphoid Follicle, Depletion Lymphoid|    2     3  3  3  2                                                      |             
      Lymphoid Follicle, Necrosis          |                         2                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  I  +  +  +  M  +  +|             
      Inflammation, Suppurative            |                         3                                                |             
      Cortex, Depletion Lymphoid           |    3  1     3  3        3  3     2           3  1              1     3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |       1              1  1                 1  2  2        1     2     2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 5| 0| 0| 0| 0| 7| 6| 6| 7| 6| 7| 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 2| 2| 6| 6| 2| 4| 2| 8| 2| 4| 2| 3| 1| 3| 3| 9| 1| 8| 3|             
                                           | 8| 8| 6| 8| 8| 8| 8| 9| 1| 5| 9| 6| 9| 6| 9| 8| 9| 3| 8| 0| 0| 2| 6| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 0| 0| 0| 0| 0| 0| 1| 2| 2| 2| 3| 3| 3| 3| 3| 4| 5| 5| 6| 6| 6| 6| 7| 8|             
    18 MG/M3                               | 6| 1| 2| 3| 4| 6| 7| 0| 7| 8| 9| 2| 4| 6| 8| 9| 0| 6| 9| 0| 1| 6| 7| 0| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  M  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |       2                                                                  |             
      Hyperplasia, Macrophage              |       2              3  3  3  3  3  3  3  3  2  3  3  3  3  3  2  2  2  3|             
      Inflammation, Chronic Active         |       1              2  2  2  2  2  2  2  3     3  3  3  3  3  1     1  3|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Perivascular, Inflammation,          |                                                                          |             
          Suppurative                      |                                              3                           |             
      Pleura, Inflammation, Suppurative    |                            1                 3                       2   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |       1              4  3  4  2  4  4  4  4     3  4  4  4  4  3  2     3|             
      Erosion, Focal                       |                                     1                                    |             
      Inflammation, Acute                  |                                     1     2                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                                          |             
      Metaplasia, Focal, Osseous           |                                           1                              |             
      Capsule, Inflammation, Suppurative   |                         2  2                                         2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Serosa, Inflammation, Suppurative    |                         4  2                                             |             
      Submucosa, Inflammation, Suppurative |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6|            |
                                           | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6|      A     |
    18 MG/M3                               | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  A  +  +  +  +  +  A  +  +  M  +  A  +  +  +  +  A|  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  A|  36        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  A|  34        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  +  I  A  A  +  +  +  +  A|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  M  M  +  A  +  M  +  M  +  A  +  I  M  M  +  I  +  +  +  A|  27        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  A|  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  M  A  +  A  +  +  A  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  A|  27        |
      Mucosa, Atrophy                      | 2                                               3  2                     |      4  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  A  +  A  A  +  +  +  +  A|  31        |
      Mucosa, Atrophy                      | 2  2        3                                      2                 3   |      6  2.3|
      Peyer's Patch, Necrosis              |                                                                          |      1  2.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  A|  31        |
      Mucosa, Atrophy                      |             3                                      2                 3   |      3  2.7|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Focal Cellular Change                | X                                                                        |      1     |
      Hematopoietic Cell Proliferation     |                      4                                                   |      2  3.0|
      Inflammation, Focal                  |                                                    3                     |      1  3.0|
      Necrosis, Focal                      |                                                 1  1                     |      2  1.0|
      Serosa, Inflammation, Suppurative    |                                                 2                       1|      5  2.4|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  44        |
      Inflammation, Focal                  |                                                    3                     |      2  2.0|
      Serosa, Inflammation, Suppurative    |                                                 3                        |      4  2.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Serosa, Inflammation, Granulomatous  |                                                                          |      1  1.0|
      Serosa, Inflammation, Suppurative    |                                                                         1|      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Focal, Mast Cell        |                                                       2                  |      1  2.0|
      Hyperplasia, Focal, Squamous         |                                                       2                  |      2  2.5|
      Glandular, Inflammation, Focal       |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  I|  46        |
      Inflammation, Suppurative            |                                                    1                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6|            |
                                           | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6|      A     |
    18 MG/M3                               | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pericardium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                         1|      4  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Inflammation, Suppurative   |                                                 3                       2|      5  2.2|
      Corticomedullary Junction, Hemorrhage|                                                                         2|      1  2.0|
      Spindle Cell, Hyperplasia            | 4  3  2     3  3  2  2  3  3  2  2  3  3  3  3  3  3  2  3  3  3  3  3  3|     47  2.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal, Suppurative     |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  M  +  I  +  M  I  +  M  +  +  +  +  +  I  I  +  I  I|  23        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  I  +  +  +  M  M  M  +  M  +  M  M  +  +  M  I  M  +  +|  25        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Focal           |                                                                          |      2  1.5|
      C-Cell, Hyperplasia                  |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                2  2  1     1           1                       1         |     10  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                  +                     |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  M  +  +  M  +  +  +  +  +  +|  46        |
      Abscess                              |                      4                          4                       4|      7  4.0|
      Cyst                                 |                                     X  X           X        X  X         |     10     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          | 3                                                                        |      1  3.0|
      Hyperplasia, Focal, Histiocytic      |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 2  3  2     2  1  2  2  1  3     3  2  3     2     1  1     2  3  2  2   |     35  1.9|
      Mucosa, Inflammation, Suppurative    |                      1                                                   |      4  1.3|
      Serosa, Inflammation, Suppurative    |                                                                         2|      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|  45        |
      Hyperplasia                          |                3                          3     2                        |      5  2.6|
      Myelofibrosis                        |       2           1     2  2  1  2  3  2     1  1           3  1  1  2   |     27  1.8|
      Myeloid Cell, Hyperplasia            |                      4                                3           3      |      3  3.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6|            |
                                           | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6|      A     |
    18 MG/M3                               | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Iliac, Hyperplasia, Lymphoid         |                                                    2                     |      1  2.0|
      Iliac, Inflammation                  |                                                    3                     |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Mixed Cell                      |                                              2                           |      1  2.0|
      Pancreatic, Follicular, Necrosis     |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                    3                     |      2  3.5|
      Renal, Infiltration Cellular, Mixed  |                                                                          |            |
          Cell                             |                                              2                           |      1  2.0|
      Renal, Inflammation                  |                                                    3                     |      1  3.0|
      Renal, Follicular, Necrosis          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Hyperplasia, Histiocytic             | 3  2  3     3  3  4  2  2  3  3  3  2  2  3  1  2  1     3  3  2     2  2|     39  2.6|
      Hyperplasia, Lymphoid                | 4     3     3     1        3  3  2  2  3        2  3        3  2     4   |     20  2.6|
      Inflammation, Acute                  |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  M  +  +  +  +  M|  36        |
      Cyst                                 |                                                 X                        |      1     |
      Hyperplasia, Lymphoid                |       2     4  3                                                         |      3  3.0|
      Inflammation                         |                                                    4                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  M  M  +  +  M  M  +  M  M  M  M  M  M  M  +  M  M  M  +  M  M|  14        |
      Hyperplasia, Histiocytic             |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                | 2                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  M  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|  37        |
      Depletion Lymphoid                   |             2                                                            |      2  2.0|
      Hematocyst                           |                                                                          |      1     |
      Hyperplasia, Histiocytic             |                                                                1         |      1  1.0|
      Hyperplasia, Lymphoid                |    2                                                                     |      2  2.5|
      Hyperplasia, Plasma Cell             |                               3                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    | 2                                            3              3     1      |      5  2.4|
      Inflammation                         |                                                    4                     |      1  4.0|
      Follicular, Necrosis                 | 3     2                    2                                             |      7  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                      3                          2  4                    2|     10  3.2|
      Hyperplasia, Lymphoid                |                3  2        3  2                                          |      6  2.3|
      Inflammation, Suppurative            |                                                 3                        |      1  3.0|
      Capsule, Inflammation, Suppurative   |                                                 4                       2|      3  2.7|
      Lymphoid Follicle, Depletion Lymphoid|                                                                          |      5  2.6|
      Lymphoid Follicle, Necrosis          |                                                                         1|      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6|            |
                                           | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6|      A     |
    18 MG/M3                               | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  I  +|  41        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Cortex, Depletion Lymphoid           |                         4                       2        2              3|     15  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess                              |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization, Focal                |    1  1     2  2  1  2  1  2  2  2  2  2     2  1  1  2     2  2  2      |     29  1.6|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Macrophage              | 3  3  3     3  3  3  3  3  3  3  3  3  3  2  3  3  2  4  3  3  3  2  3  3|     43  2.8|
      Inflammation, Chronic Active         | 3  2  2     3  3  3  2  2  2  2  3  2  3     3  2  2     1  2  3     3  2|     38  2.3|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |       1                                                                  |      1  1.0|
      Perivascular, Inflammation,          |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Pleura, Inflammation, Suppurative    |                                                 2                       1|      5  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cytoplasmic Alteration, Focal        | 4  4  4     4  3  4  4  4  3  3  3  3  3  3  4  2     2  1  3  4  4  4  2|     40  3.3|
      Erosion, Focal                       |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                     1     2        1                     |      5  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  M  +  I  +  A  +  +  +  M  +  +  +  +  +  +|  45        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 0| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 4| 6| 5| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 3| 3| 3| 2| 3| 0| 3| 3| 5| 3| 3| 3| 3| 3| 4| 3| 0| 7| 5| 5| 3| 3| 3| 3| 6|            |
                                           | 0| 3| 3| 0| 1| 6| 1| 1| 4| 1| 1| 3| 2| 2| 2| 2| 8| 3| 5| 8| 2| 2| 2| 3| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 8| 8| 9| 9| 9| 9| 9| 9| 1| 1| 1| 2| 2| 2| 2| 2| 4| 4| 5| 5| 5| 5| 5| 5| 6|      A     |
    18 MG/M3                               | 8| 9| 0| 2| 4| 6| 8| 9| 6| 7| 9| 2| 4| 6| 8| 9| 6| 9| 2| 3| 4| 5| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Focal                  |                                                    2                     |      1  2.0|
      Metaplasia, Focal, Osseous           |       1                                                                  |      2  1.0|
      Capsule, Inflammation, Suppurative   |                                                 1                       1|      5  1.6|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  A  +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|  41        |
      Serosa, Inflammation, Suppurative    |                                                 2                        |      3  2.7|
      Submucosa, Inflammation, Suppurative |                                                    1                     |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 1| 5| 1| 7| 1| 5| 5| 4| 7| 5| 5| 0| 1| 7| 7| 7| 7| 3| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 4| 6| 8| 4| 8| 1| 8| 4| 4| 0| 1| 4| 3| 2| 8| 3| 0| 3| 3| 6| 0| 3| 5|             
                                           | 2| 2| 9| 9| 5| 9| 5| 1| 6| 9| 9| 4| 5| 9| 2| 8| 6| 2| 1| 2| 2| 8| 4| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7|             
    CONTROL                                | 8| 9| 0| 3| 5| 7| 8| 6| 7| 8| 0| 2| 3| 4| 9| 6| 7| 8| 9| 7| 8| 9| 6| 8| 2|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  I  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +           +  +           +                                 |             
      Clear Cell Focus                     |                                                                          |             
      Inflammation, Focal                  |          2                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +           +  +           +                                 |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Hyperplasia                    |             3                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +           +  +           +                                 |             
      Spindle Cell, Hyperplasia            |       2                    2           2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  M  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       M  +  M           +  M           M                                 |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  M           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +           +  +           +                                 |             
      Endometrium, Hyperplasia, Cystic     |       2                    3           1                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 1| 5| 1| 7| 1| 5| 5| 4| 7| 5| 5| 0| 1| 7| 7| 7| 7| 3| 5| 7| 5|             
                             DAY ON TEST   | 3| 3| 4| 6| 8| 4| 8| 1| 8| 4| 4| 0| 1| 4| 3| 2| 8| 3| 0| 3| 3| 6| 0| 3| 5|             
                                           | 2| 2| 9| 9| 5| 9| 5| 1| 6| 9| 9| 4| 5| 9| 2| 8| 6| 2| 1| 2| 2| 8| 4| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 7|             
    CONTROL                                | 8| 9| 0| 3| 5| 7| 8| 6| 7| 8| 0| 2| 3| 4| 9| 6| 7| 8| 9| 7| 8| 9| 6| 8| 2|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |       +  +  +           +  M           +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  M  +           M  +           M                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |       +  +  M           M  +           +                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +           +  +           +                                 |             
      Cortex, Depletion Lymphoid           |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +           +  +           +                                 |             
      Mineralization, Focal                |       2                    1           2                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +           +  +           +                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +           +  +           +                                 |             
      Inflammation, Focal                  |          2                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +           +  +           +                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 3| 1| 3| 5| 1| 3| 1| 5| 3| 6| 5| 3|                                |            |
                             DAY ON TEST   | 8| 3| 6| 8| 6| 4| 8| 6| 8| 5| 6| 9| 7| 6|                                |            |
                                           | 6| 2| 8| 6| 9| 9| 7| 9| 7| 0| 9| 4| 6| 9|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                |      T     |
                               ANIMAL ID   | 7| 7| 9| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 4|                                |      A     |
    CONTROL                                | 6| 7| 8| 9| 3| 6| 8| 0| 6| 2| 5| 6| 7| 0|                                |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M           +  +  +           +                                          |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +           +  +  +           +                                          |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +           +  +  +           +                                          |  11        |
      Clear Cell Focus                     |                               X                                          |      1     |
      Inflammation, Focal                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +           +  +  +           +                                          |  11        |
      Inflammation, Chronic                |             1                                                            |      1  1.0|
      Duct, Hyperplasia                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +           +  M  +           +                                          |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +           +  +  +           +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +           +  +  +           +                                          |  11        |
      Spindle Cell, Hyperplasia            |                2                                                         |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +           +  +  +           +                                          |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +           +  M  M           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +           +  +  M           +                                          |  10        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +           +  M  +           +                                          |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                 +                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +           +  +  +           +                                          |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 3| 1| 3| 5| 1| 3| 1| 5| 3| 6| 5| 3|                                |            |
                             DAY ON TEST   | 8| 3| 6| 8| 6| 4| 8| 6| 8| 5| 6| 9| 7| 6|                                |            |
                                           | 6| 2| 8| 6| 9| 9| 7| 9| 7| 0| 9| 4| 6| 9|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                |      T     |
                               ANIMAL ID   | 7| 7| 9| 9| 0| 0| 0| 1| 2| 3| 3| 3| 3| 4|                                |      A     |
    CONTROL                                | 6| 7| 8| 9| 3| 6| 8| 0| 6| 2| 5| 6| 7| 0|                                |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +           +  +  +           +                                          |  11        |
      Endometrium, Hyperplasia, Cystic     |                2                                                         |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +           M  +  +           +                                          |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +           +  +  M           +                                          |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +           M  M  M           M                                          |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +           +  +  +           +                                          |  11        |
      Cortex, Depletion Lymphoid           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +           +  +  +           +                                          |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +           +  +  +           +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +           +  +  +           +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +           +  +  +           +                                          |  11        |
      Mineralization, Focal                |             1  2                                                         |      5  1.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +           +  +  +           +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +           +  +  +           +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +           +  +  +           +                                          |  11        |
      Inflammation, Focal                  |             2                 1                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +           +  +  +           +                                          |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 5| 3| 3| 7| 1| 7| 6| 3| 1| 1| 6| 5| 7| 7| 1| 5| 0| 6| 7| 1| 3| 0| 5|             
                             DAY ON TEST   | 6| 4| 4| 6| 6| 1| 8| 3| 5| 6| 8| 8| 5| 4| 3| 3| 8| 4| 1| 7| 3| 8| 6| 0| 2|             
                                           | 9| 9| 9| 8| 9| 7| 5| 2| 9| 8| 5| 6| 5| 9| 2| 2| 6| 9| 7| 8| 2| 7| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 4| 4| 4| 5| 5| 5| 7| 7| 8| 8| 8| 8| 8| 1| 1| 1| 1|             
    6 MG/M3                                | 7| 8| 1| 3| 5| 6| 7| 8| 6| 8| 9| 1| 7| 9| 7| 9| 0| 2| 4| 6| 8| 0| 2| 3| 4|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        M     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +        +     M              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +        +     +              +     +           +              M      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +        +     +              +     +           +              +      |             
      Inflammation, Focal                  |                                                                   1      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +     +              +     M           +              +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +     +              +     +           +              +      |             
      Inflammation, Chronic                | 2                                1                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +     +              +     +           +              +      |             
      Hyperplasia, Focal, Squamous         |             1                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +        +     +              +     +           +              +      |             
      Spindle Cell, Hyperplasia            |    2                                   3           2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +        +     +              +     +                          +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +        +     +              +     +                          +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +     +              +     M           +              +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +        +     M              M     M           M              M      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +        +     M              M     +           +              +      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +        +     +              +     +           M              +      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +           +                                                     +      |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +        M     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +        +     +              +     +           +              +      |             
      Endometrium, Hyperplasia, Cystic     |    1        2                          3           3                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +     +              +     +           +              +      |             
      Myelofibrosis                        |                                        1           1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 5| 5| 3| 3| 7| 1| 7| 6| 3| 1| 1| 6| 5| 7| 7| 1| 5| 0| 6| 7| 1| 3| 0| 5|             
                             DAY ON TEST   | 6| 4| 4| 6| 6| 1| 8| 3| 5| 6| 8| 8| 5| 4| 3| 3| 8| 4| 1| 7| 3| 8| 6| 0| 2|             
                                           | 9| 9| 9| 8| 9| 7| 5| 2| 9| 8| 5| 6| 5| 9| 2| 2| 6| 9| 7| 8| 2| 7| 9| 4| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 4| 4| 4| 5| 5| 5| 7| 7| 8| 8| 8| 8| 8| 1| 1| 1| 1|             
    6 MG/M3                                | 7| 8| 1| 3| 5| 6| 7| 8| 6| 8| 9| 1| 7| 9| 7| 9| 0| 2| 4| 6| 8| 0| 2| 3| 4|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +        +     M              +     +           +              M      |             
      Hyperplasia, Histiocytic             |                                        1                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +        +     +              +     +           +              +      |             
      Hyperplasia, Plasma Cell             |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +        +     M              +     M           +              M      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +        +     +              +     +           +              +      |             
      Hyperplasia, Histiocytic             |                                        2                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +     +              +     +           +              +      |             
      Mineralization, Focal                |    2        2                          2           2              1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +        +     +              +     +           +              +      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +        +     +              +     +           +              +      |             
      Hyperplasia, Macrophage              | 1  2        1                          1           1              1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        +     +              +     +           +              +      |             
      Cytoplasmic Alteration, Focal        |    2        1                                      1              1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                        +                                 |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +     +              +     +           +              +      |             
      Inflammation, Focal                  |             2                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +     +              +     +           +              +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1|                             |            |
                             DAY ON TEST   | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8|                             |            |
                                           | 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      T     |
                               ANIMAL ID   | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7|                             |      A     |
    6 MG/M3                                | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +     +  +  M                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +     +  +  +                                             |  12        |
      Inflammation, Focal                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +     +  +  +                                             |  12        |
      Inflammation, Chronic                |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +     +  +  +                                             |  12        |
      Hyperplasia, Focal, Squamous         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +     +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                M     +  +  +                                             |  11        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                +     +  +  +                                             |  12        |
      Spindle Cell, Hyperplasia            |                         2                                                |      4  2.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                I     +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                M     M  +  M                                             |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                M     M  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                M     M  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                +     +  +  +                                             |  11        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                +     +  +  +                                             |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1|                             |            |
                             DAY ON TEST   | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8|                             |            |
                                           | 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      T     |
                               ANIMAL ID   | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7|                             |      A     |
    6 MG/M3                                | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Hyperplasia, Cystic     |                         2                                                |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +     +  +  +                                             |  12        |
      Myelofibrosis                        |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                M     M  +  M                                             |   6        |
      Hyperplasia, Histiocytic             |                         1                                                |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +     +  M  +                                             |  11        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |                M     M  M  M                                             |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +     +  M  +                                             |  11        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +     +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +     +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +     +  +  +                                             |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +     +  +  +                                             |  12        |
      Mineralization, Focal                |                            1                                             |      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                +     +  +  +                                             |  12        |
                                            __________________________________________________________________________|____________|
   Lung                                    |                +     +  +  +                                             |  12        |
      Hyperplasia, Macrophage              |                         1  1                                             |      8  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    |                +     +  +  +                                             |  12        |
      Cytoplasmic Alteration, Focal        |                            1                                             |      5  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                M     +  +  +                                             |  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                +                                                         |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 4| 6| 5| 1| 3| 1| 5| 3| 7| 3| 7| 5| 1|                             |            |
                             DAY ON TEST   | 4| 9| 5| 1| 5| 8| 6| 8| 4| 6| 3| 6| 3| 5| 8|                             |            |
                                           | 9| 7| 3| 7| 0| 7| 9| 7| 9| 9| 2| 9| 2| 0| 7|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      T     |
                               ANIMAL ID   | 1| 1| 3| 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 7| 7|                             |      A     |
    6 MG/M3                                | 6| 9| 7| 1| 2| 3| 6| 9| 0| 7| 0| 3| 4| 7| 9|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +     +  +  +                                             |  12        |
      Inflammation, Focal                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +     +  +  +                                             |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 1| 7| 0| 0| 4| 3| 1| 7| 3| 5| 3| 7| 5| 1| 2| 3| 5| 1| 5| 1| 5| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 9| 6| 8| 3| 6| 4| 6| 3| 0| 8| 8| 6| 4| 8| 4| 8| 4| 3| 3|             
                                           | 8| 8| 4| 2| 8| 8| 5| 9| 6| 2| 8| 6| 9| 2| 8| 5| 6| 8| 9| 7| 9| 5| 9| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 9| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 5| 5| 6| 6| 6| 6| 6| 6| 8| 9| 9| 9|             
    18 MG/M3                               | 7| 8| 9| 0| 5| 8| 9| 6| 0| 1| 3| 5| 7| 7| 8| 2| 3| 4| 5| 8| 9| 7| 1| 3| 5|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                      M              +        +              +            |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                      M              M        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Liver                                   |                      +              +        +              +            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Stomach                                 |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                      +              +        +              +            |             
      Spindle Cell, Hyperplasia            |                                                             3            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                      +              I        +              +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                      M              +        +              +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                      M              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                      +              +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Uterus                                  |                      +              +        +              +            |             
      Endometrium, Cyst                    |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                             4            |             
      Mucosa, Inflammation, Suppurative    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                      +              +        +              +            |             
      Myelofibrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 0| 1| 7| 0| 0| 4| 3| 1| 7| 3| 5| 3| 7| 5| 1| 2| 3| 5| 1| 5| 1| 5| 7| 7|             
                             DAY ON TEST   | 2| 2| 1| 2| 2| 2| 9| 6| 8| 3| 6| 4| 6| 3| 0| 8| 8| 6| 4| 8| 4| 8| 4| 3| 3|             
                                           | 8| 8| 4| 2| 8| 8| 5| 9| 6| 2| 8| 6| 9| 2| 8| 5| 6| 8| 9| 7| 9| 5| 9| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 9| 9| 0| 0| 0| 0| 2| 3| 3| 3| 3| 3| 5| 5| 6| 6| 6| 6| 6| 6| 8| 9| 9| 9|             
    18 MG/M3                               | 7| 8| 9| 0| 5| 8| 9| 6| 0| 1| 3| 5| 7| 7| 8| 2| 3| 4| 5| 8| 9| 7| 1| 3| 5|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |                      +              +        +              +            |             
      Hyperplasia, Histiocytic             |                      1              2                       3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                      +              +        +              +            |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |                      I              M        M              M            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                      +              +        +              +            |             
      Hyperplasia, Histiocytic             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                      +              +        +              +            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Skin                                    |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                      +              +        +              +            |             
      Mineralization, Focal                |                      1              1                       2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Lung                                    |                      +              +        +              +            |             
      Hyperplasia, Macrophage              |                      2              2        1              2            |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                      +              +        +              +            |             
      Cytoplasmic Alteration, Focal        |                      2              2                       2            |             
      Cytoplasmic Alteration               |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                      +              +        +              +            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                      +              +        +              +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3|                             |            |
                             DAY ON TEST   | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6|                             |            |
                                           | 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE FEMALE                      | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |      T     |
                               ANIMAL ID   | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5|                             |      A     |
    18 MG/M3                               | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +        +        M                                       |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M  +  +  +  +  +        +        +                                       |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +        +        +                                       |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +        +        +                                       |  12        |
      Hematopoietic Cell Proliferation     |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +        +        +                                       |  12        |
      Spindle Cell, Hyperplasia            |             3  3        3                                                |      4  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  +  +  +        +        +                                       |  11        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +        +        +                                       |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  +        +        +                                       |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +        +        +                                       |  11        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                             +                                       |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +        +        +                                       |  12        |
      Endometrium, Cyst                    |             X                                                            |      1     |
      Endometrium, Hyperplasia, Cystic     |          2  3  3        2                                                |      5  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3|                             |            |
                             DAY ON TEST   | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6|                             |            |
                                           | 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE FEMALE                      | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |      T     |
                               ANIMAL ID   | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5|                             |      A     |
    18 MG/M3                               | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Inflammation, Suppurative    |                                  3                                       |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +        A        +                                       |  11        |
      Myelofibrosis                        |             2                                                            |      1  2.0|
      Myeloid Cell, Hyperplasia            |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | I  +  +  +  +  +        +        +                                       |  11        |
      Hyperplasia, Histiocytic             |    2        4  3        3        3                                       |      8  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M        +        +                                       |  11        |
      Hyperplasia, Histiocytic             |                         2                                                |      1  2.0|
      Hyperplasia, Lymphoid                |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  M  M  M        M        M                                       |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     M        +        +                                       |  10        |
      Hyperplasia, Histiocytic             |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +        +        +                                       |  12        |
      Hematopoietic Cell Proliferation     |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +        +        +                                       |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +        +        +                                       |  12        |
      Mineralization, Focal                |    1                                                                     |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +        +        +                                       |  12        |
      Hyperplasia, Macrophage              | 1  2  1  1  3  3        2        2                                       |     12  1.8|
      Inflammation, Chronic Active         |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +        +        +                                       |  12        |
      Cytoplasmic Alteration, Focal        |    2        2  2        2        2                                       |      8  2.0|
      Cytoplasmic Alteration               |       1                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +        +        +                                       |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 3| 1| 1| 5| 5| 5| 3| 5| 6| 1| 3| 7| 5| 3|                             |            |
                             DAY ON TEST   | 8| 6| 8| 8| 4| 4| 5| 6| 4| 0| 8| 6| 3| 5| 6|                             |            |
                                           | 6| 9| 7| 7| 9| 9| 0| 9| 9| 4| 7| 9| 2| 0| 9|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE FEMALE                      | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |      T     |
                               ANIMAL ID   | 9| 0| 1| 2| 2| 2| 2| 2| 3| 4| 4| 5| 5| 5| 5|                             |      A     |
    18 MG/M3                               | 7| 0| 8| 0| 1| 3| 5| 7| 0| 7| 8| 0| 1| 6| 7|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +        +        +                                       |  12        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +        +        +                                       |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|             
                                           | 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|             
    CONTROL                                | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  M  +  +  M     +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  M  +  +  A  A  +  M  +  +  +     +  +  M  A  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  A  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
      Mucosa, Atrophy                      |                                  4        2                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                                             2  2  2      |             
      Mucosa, Atrophy                      |                               2  4                                       |             
      Peyer's Patch, Necrosis              |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  +  +     +  +  +  A  +  +  M  +  +  +  +  A|             
      Mucosa, Atrophy                      |                                  4                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Abscess                              |                                                                          |             
      Focal Cellular Change                |                                                    X                     |             
      Hematopoietic Cell Proliferation     |                                                                   4      |             
      Infarct                              |                                  4                 3                     |             
      Necrosis, Focal                      |                                  4                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  I     +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  M  A  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Myocardium, Degeneration, Focal      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | I  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Spindle Cell, Hyperplasia            |    1  1        2     1  1  1     3     1  2  1  1  1     1  1  4  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | I  +  +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Atrophy                              |                                                                3         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +  +  +  M  M  M  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  M  +  +  I  M     +  +  +  A  +  M  I  +  +  I  +  M|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  +  M  M  M  M  +  M  +     +  M  +  +  +  +  M  M  M  +  +  M|             
      Cyst                                 |                                                    X                 X   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  I  +     +  +  +  +  +  +  +  +  +  +  +  M|             
      Cyst                                 |                                                                      X   |             
      Pigmentation, Lipofuscin             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|             
                                           | 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|             
    CONTROL                                | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Cyst                                 |                                                                          |             
      Follicular Cell, Hyperplasia         |                            1                       1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  M  +  +  M  +  +  I  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                4                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                                                        |             
      Dilatation                           | 3                                                                        |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  I  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
      Hypospermia                          |                                                                          |             
      Seminiferous Tubule, Degeneration,   |                                                                          |             
           Focal                           |                                                             1  1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  A     +  +  +  A  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |                               2                                          |             
      Myelofibrosis                        |                                              1                           |             
      Myeloid Cell, Hyperplasia            |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M|             
      Iliac, Hyperplasia, Lymphoid         |          2                                                               |             
      Iliac, Hyperplasia, Plasma Cell      |          3                                                               |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  I  +  +     +  M  +  +  +  +  +  +  M  M  +  M|             
      Hyperplasia, Histiocytic             |                                  3                                       |             
      Hyperplasia, Lymphoid                | 2  4                                                                     |             
      Infiltration Cellular, Mixed Cell    |                2                                                         |             
      Inflammation, Acute                  |                                                                          |             
      Follicular, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  M  +  M  +  +  M  M  M  M     +  M  M  M  +  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  M  M  I  +  M  M  +  +     M  M  M  M  +  M  M  M  M  M  M  M|             
      Hyperplasia, Histiocytic             |                                  3                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  I  M  +  M  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  M|             
      Depletion Lymphoid                   |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Mixed Cell    |          3                       3     2           2  2        1     3   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|             
                                           | 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|             
    CONTROL                                | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |          3                                                               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphoid Follicle, Necrosis          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  M  +  +  I  I  +  M     +  +  +  A  +  +  +  +  +  +  +  M|             
      Cyst                                 |             X                             X                              |             
      Necrosis                             |                   3                                                      |             
      Cortex, Depletion Lymphoid           |    2              2                                                      |             
      Epithelial Cell, Hyperplasia, Focal  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  +  +     M  M  M  +  M  M  M  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Rib, Cartilage, Fracture Healed      |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                | 1     2  2  1  2  2  1        2  2     1     2  2  2  3  2     1  2  1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  I  +  +  +  +  +  I  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Congestion                           |                   2                                                      |             
      Hyperplasia, Macrophage              |    4                                      2                              |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Perivascular, Inflammation,          |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |       1              1                    1           1                  |             
      Erosion, Focal                       |                                                             1            |             
      Inflammation, Acute                  |    1  2                                                     1            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 5| 4| 7| 4| 7| 7| 5| 0| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 0|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 2| 3| 3| 3| 7| 3| 3| 3| 4| 4| 3| 3| 0|             
                                           | 6| 6| 6| 6| 6| 8| 6| 6| 2| 6| 0| 5| 0| 7| 7| 7| 1| 7| 7| 7| 0| 0| 8| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 6| 6| 6| 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3|             
    CONTROL                                | 1| 4| 7| 0| 1| 2| 4| 5| 1| 2| 3| 5| 6| 8| 2| 3| 5| 1| 3| 4| 6| 7| 1| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  A|             
      Casts Protein                        |                   3                                                      |             
      Cyst                                 |                X                                                         |             
      Hydronephrosis                       |          2     3  2                                                      |             
      Inflammation, Focal, Suppurative     |                                                                          |             
      Nephropathy, Chronic                 |                4                                                         |             
      Pelvis, Inflammation, Suppurative    |                4                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  A|             
      Dysplasia, Focal                     |          3                                                               |             
      Inflammation, Chronic Active         |          3     3  1                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6|  |            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9|  |            |
                                           | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2|  |      A     |
    CONTROL                                | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +      |  41        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +     +  +  +  +  +  +  +  +  A  M  +  M  A  A  +  +  A      |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +  +     +  +  +  +  +  +  +  +  A  A  +  A  A  A  +  +  +      |  36        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +     +  +  +  +  +  A  +  +  A  A  +  A  A  A  +  +  A      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +     +  +  +  +  +  +  +  +  A  A  +  A  A  A  +  +  +      |  36        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | I  +  A  +  +     +  +  +  +  +  A  +  M  A  A  +  A  A  A  +  +  M      |  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +     +  +  +  +  +  A  +  +  A  A  +  A  A  A  +  +  A      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +     +  +  +  M  +  A  +  +  A  A  +  A  A  A  +  +  A      |  32        |
      Mucosa, Atrophy                      | 3                                                                        |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +     +  +  +  +  +  A  +  A  A  A  +  A  A  A  +  +  A      |  33        |
      Hyperplasia, Lymphoid                |          2  2                                                            |      5  2.0|
      Mucosa, Atrophy                      | 3                                                                        |      3  3.0|
      Peyer's Patch, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +     +  +  +  +  +  A  +  A  A  A  +  A  A  A  +  +  A      |  32        |
      Mucosa, Atrophy                      | 3  3                                                                     |      3  3.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Abscess                              |       4                                                                  |      1  4.0|
      Focal Cellular Change                |                   X        X                    X                        |      4     |
      Hematopoietic Cell Proliferation     |                                     2                                    |      2  3.0|
      Infarct                              |                                                                          |      2  3.5|
      Necrosis, Focal                      |                                     1                 4           1      |      4  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +      |  42        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M      |  43        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I  +      |  39        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Myocardium, Degeneration, Focal      |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
      Spindle Cell, Hyperplasia            | 1  1  2  3  3     2  1  2  2  2     2  1  2  1  2  1  2  3  3  2  2      |     38  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I      |  39        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  I  M  +     M  I  +  I  I  +  M  I  +  +  +  +  I  A  M  +  +      |  26        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6|  |            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9|  |            |
                                           | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2|  |      A     |
    CONTROL                                | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M     +  +  +  +  +  +  M  M  M  +  M  +  +  +  +  M  +      |  25        |
      Cyst                                 |                            X                                             |      3     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
      Cyst                                 |                                                                          |      1     |
      Pigmentation, Lipofuscin             |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Cyst                                 |                         X                                   X            |      2     |
      Follicular Cell, Hyperplasia         |                   1           1                                          |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  M  +     +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +      |  39        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +              +  +        +     +                 +  +            |   8        |
      Dilatation                           |       3              4  4              3                 4  2            |      7  3.3|
      Inflammation                         |                                  4     2                 4               |      3  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | M  +  M  I  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |  40        |
      Inflammation, Suppurative            |                                  3     2                          1      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  A      |  41        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +      |  43        |
      Hypospermia                          |                                                                X         |      1     |
      Seminiferous Tubule, Degeneration,   |                                                                          |            |
           Focal                           |                               1                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +      |  40        |
      Hyperplasia                          |                                                 3  2  3                  |      4  2.5|
      Myelofibrosis                        | 1                                                                        |      2  1.0|
      Myeloid Cell, Hyperplasia            |                                  3     2                          4      |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
      Lumbar, Hyperplasia, Lymphoid        |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +     +  +  +  +  M  +  +  +  M  I  M  +  +  I  M  M  I      |  32        |
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |       3                                                                  |      3  3.0|
      Infiltration Cellular, Mixed Cell    |                                                    3  1                  |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6|  |            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9|  |            |
                                           | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2|  |      A     |
    CONTROL                                | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |       4                                                                  |      1  4.0|
      Follicular, Necrosis                 |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  M  M  +     +  M  +  +  +  M  +  +  +  M  M  M  M  M  +  +  M      |  23        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  M  M     M  M  M  M  +  M  M  M  +  M  M  M  M  M  +  M  M      |   9        |
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  A  +  +     +  +  +  I  +  M  +  +  +  M  +  +  +  A  +  +  +      |  36        |
      Depletion Lymphoid                   |                                        3                                 |      1  3.0|
      Hyperplasia, Lymphoid                |          2  3                 2     2                                    |      4  2.3|
      Infiltration Cellular, Mixed Cell    | 2  3                          2     3  4  3        3  3     1  3  3      |     18  2.6|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
      Hematopoietic Cell Proliferation     |       3                                3              2  2        2      |      6  2.5|
      Hyperplasia, Lymphoid                |          2                                            3  2               |      3  2.3|
      Lymphoid Follicle, Necrosis          |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | I  +  M  +  +     +  +  +  +  +  +  +  I  M  M  +  +  +  +  +  +  +      |  34        |
      Cyst                                 |    X                                                                     |      3     |
      Necrosis                             |                                                                          |      1  3.0|
      Cortex, Depletion Lymphoid           |                                  2                 2  3           2      |      6  2.2|
      Epithelial Cell, Hyperplasia, Focal  |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M     +  M  I  M  M  M  M  M  M  M  M  M  M  I  M  M  M      |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  I  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +      |  44        |
      Alopecia                             |       X                                                                  |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Rib, Cartilage, Fracture Healed      |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Mineralization, Focal                | 1  2  2  2  2     2     2  2     1  1  2  2  2  2     1  2  2  2  2      |     37  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  42        |
      Inflammation, Acute                  |                                                       1                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Congestion                           |                                           3              4               |      3  3.0|
      Hyperplasia, Macrophage              |                      1                                                   |      3  2.3|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 6| 7| 4| 7| 7| 7| 7| 7| 5| 7| 6| 5| 4| 7| 5| 7| 5| 7| 7| 6| 6|  |            |
                             DAY ON TEST   | 3| 3| 3| 8| 3| 2| 3| 4| 4| 3| 3| 8| 3| 7| 4| 8| 3| 7| 1| 8| 4| 4| 2| 9|  |            |
                                           | 8| 8| 7| 4| 8| 3| 8| 0| 0| 9| 9| 7| 9| 7| 3| 4| 9| 9| 0| 7| 0| 0| 9| 1|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 2| 2| 2| 2|  |      A     |
    CONTROL                                | 1| 2| 4| 5| 8| 3| 4| 2| 4| 5| 8| 9| 2| 3| 4| 2| 3| 5| 7| 8| 0| 1| 3| 5|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Focal                           |                         1                                                |      1  1.0|
      Perivascular, Inflammation,          |                                                                          |            |
          Suppurative                      |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Cytoplasmic Alteration, Focal        |                                                                1         |      5  1.0|
      Erosion, Focal                       |                                                                          |      1  1.0|
      Inflammation, Acute                  |                      1                                                   |      4  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +      |  42        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
      Inflammation, Granulomatous          |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Casts Protein                        |                                                                          |      1  3.0|
      Cyst                                 |                   X                                                      |      2     |
      Hydronephrosis                       |                                                                          |      3  2.3|
      Inflammation, Focal, Suppurative     |                                  4     4                          4      |      3  4.0|
      Nephropathy, Chronic                 |       3                                      4                           |      3  3.7|
      Pelvis, Inflammation, Suppurative    |                                              4                           |      2  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +      |  43        |
      Dysplasia, Focal                     |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                  3     3                          2      |      6  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|             
                                           | 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
    6 MG/M3                                | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  +  A  +  +  A  +  A  A  +  I  +  +  +  I     +  +  I   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  A  +  +  A  +  A  A  +  +  +  +  +  +     +  +  A   |             
      Hyperplasia, Lymphoid                |                                                                2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  A  I  A  M  +  +  +  +  +  +     M  +  A   |             
      Serosa, Inflammation, Suppurative    |                                           4                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  A  +  +  A  +  A  A  +  +  +  +  +  +     +  +  A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  M  +  +  A  +  M  A  +  A  A  +  +  +  +  +  +     +  +  A   |             
      Mucosa, Atrophy                      |                2                          3                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  A  +  +  A  +  A  A  +  A  +  +  +  +     +  +  A   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mucosa, Atrophy                      |                                           3                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  A  +  +  A  +  A  A  +  +  +  +  M  +     +  +  A   |             
      Mucosa, Atrophy                      |                                           3                              |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Focal Cellular Change                |                                  X           X  X                        |             
      Hematocyst                           |                X                                                         |             
      Hematopoietic Cell Proliferation     | 2                                                                        |             
      Inflammation, Focal                  |                                                                   1      |             
      Mineralization, Focal                |                         1                                                |             
      Necrosis, Focal                      |                                     2           1                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  I   |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Thrombosis                           |                                                                          |             
      Coronary Artery, Mineralization      |                                                                          |             
      Myocardium, Fibrosis, Focal          |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Spindle Cell, Hyperplasia            | 2     1  2  2  3     2     2     2  2  1  1  1  2  2  3  1     2     2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Hyperplasia, Focal                   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|             
                                           | 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
    6 MG/M3                                | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  I   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  A  M  I  M  +  M  +  M  I  M  M  +  M  M  +  I  +     I  +  +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  M  M  M  +  +  M  M  +  M  M  +  M  +  +  I  M     I  M  +   |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Cyst                                 |                                                                          |             
      Follicular Cell, Hyperplasia         |                            2     2     1              2  2        2  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +              +                           |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  M  +  +  I  +  A  +  +  +  +  +  +  +  +  +     M  +  +   |             
      Inflammation, Suppurative            |                      4                                                   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +                                      +                           |             
      Dilatation                           |       3                                      2                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +     +  +  +   |             
      Inflammation, Suppurative            |                      4        3                                      3   |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Inflammation, Suppurative            |                      4                                               2   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Hypospermia                          |                                                                          |             
      Inflammation, Suppurative            |                      4                                                   |             
      Seminiferous Tubule, Degeneration,   |                                                                          |             
           Focal                           |       1                                   1     1                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Hyperplasia                          | 3                                                                        |             
      Myelofibrosis                        |                                                 1                 1      |             
      Myeloid Cell, Hyperplasia            |                               3           2     4                    2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Lumbar, Hyperplasia, Lymphoid        |                                                                   3      |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                   3      |             
      Pancreatic, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  +  +  +  I  +  +  M  M  +  +     +  +  +   |             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |             
      Hyperplasia, Histiocytic             | 1  2     2  2  2  1  1  1  2     3  2        2        2  2     2  4  1   |             
      Hyperplasia, Lymphoid                |                         2  1                          1        1         |             
      Infiltration Cellular, Mixed Cell    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  M  M  M  +  M  +  +  +  M  +  M  +  +  +  M  M  +  M     M  M  M   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|             
                                           | 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
    6 MG/M3                                | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Histiocytic             |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  M  M  M  M  M  +  M  M  +  M  M  M  M  M  M  M  +     M  M  M   |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                         1                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  M  +  +  +  M  +  +  M  +  M  +  +  M  +  +  +  +     +  +  +   |             
      Hyperplasia, Lymphoid                |                                                    2  3                  |             
      Infiltration Cellular, Mixed Cell    |             3              2                       2  2        3     3   |             
      Inflammation, Granulomatous          |                                                                          |             
      Follicular, Necrosis                 |                                                                2     2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +     +  +  +   |             
      Hematocyst                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 2                                   2     2                              |             
      Hyperplasia, Lymphoid                | 3                                               2                        |             
      Inflammation, Granulomatous          |                                                                          |             
      Lymphoid Follicle, Depletion Lymphoid|                                                                          |             
      Lymphoid Follicle, Necrosis          |                                     3        3                       3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  A  +  M  +  M  M  M  I  +  +     +  M  +   |             
      Cyst                                 |                                  X                                       |             
      Inflammation, Granulomatous          |                                                                          |             
      Cortex, Depletion Lymphoid           |                1     3                                               2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  M     M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Abscess                              |                                                                          |             
      Inflammation, Acute                  |                               4                                          |             
      Ulcer, Focal                         |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Mineralization, Focal                | 2  2  2     2     2  1  2     1  2  2  2     1  2  1  2  2     1  2  2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  I  +  A  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +     +  +  +   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Congestion                           |                                     3                                    |             
      Hyperplasia, Macrophage              | 1  1  2  2  2  1  1  1  1  2     1  2  1  1  1  2  1  1  1     2  2  1   |             
      Inflammation, Chronic Active         |       1     1           3  1     1  1           1     1        1  1      |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 2| 7| 6| 5| 6| 3| 6| 7| 7| 7| 3| 7| 7| 6| 0|             
                             DAY ON TEST   | 3| 3| 3| 2| 3| 3| 3| 1| 4| 3| 5| 3| 3| 5| 2| 4| 8| 3| 3| 3| 2| 3| 3| 2| 6|             
                                           | 6| 6| 6| 3| 6| 6| 6| 0| 0| 7| 3| 7| 3| 8| 4| 4| 8| 7| 7| 7| 0| 7| 7| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7|             
    6 MG/M3                                | 1| 4| 5| 7| 8| 0| 4| 5| 2| 3| 5| 6| 8| 0| 1| 2| 1| 4| 5| 6| 8| 1| 2| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Cytoplasmic Alteration, Focal        | 2  2  1     3  3  2  1  1  1     1  3           1        2     2  3      |             
      Erosion, Focal                       |                                                                          |             
      Inflammation, Acute                  |       1        1                                         1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  I  +  +  +  +  +  +     +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +   |             
      Hydronephrosis                       |                                                 4                        |             
      Inflammation, Focal, Suppurative     |                               4                                      4   |             
      Metaplasia, Focal, Osseous           |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                 4                    4   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  A  +  +  +  A  +  +  A  +  A  A  +  +  +  +  +  +     +  +  +   |             
      Inflammation, Chronic Active         |                                                 3                    3   |             
      Transitional Epithelium, Hyperplasia |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5|  |            |
                                           | 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6|  |      A     |
    6 MG/M3                                | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  A  +  M  A  +  +  +  A  M  M  +  A  A  +  +  A  +  +  A   |  29        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A   |  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  A  +  +  +  A  +  A  +  A  +  +  +  +  +  +  A   |  35        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A   |  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  +  +  A  +  +  A  +  +  +  A  +  +  +  A  M  +  +  +  +  M  A   |  32        |
      Serosa, Inflammation, Suppurative    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  A  +  +  +  A  A  A  +  A  +  +  +  +  +  +  A   |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  A  +  +  +  A  A  A  +  A  +  +  A  A  +  +  A   |  30        |
      Mucosa, Atrophy                      | 2     2                    2  2                                2         |      7  2.1|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  A  +  +  +  A  A  A  +  A  +  +  +  A  +  +  A   |  32        |
      Hyperplasia, Lymphoid                | 4                          2                       4                     |      3  3.3|
      Mucosa, Atrophy                      |                      2     2     2                             2         |      5  2.2|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  A  +  +  +  A  A  A  +  A  A  +  +  +  M  +  A   |  31        |
      Mucosa, Atrophy                      | 2                          2                                             |      3  2.3|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Focal Cellular Change                |                                                                          |      3     |
      Hematocyst                           |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                3                                                         |      2  2.5|
      Inflammation, Focal                  |          1                                         1                     |      3  1.0|
      Mineralization, Focal                |                                                                          |      1  1.0|
      Necrosis, Focal                      |                         3                       2           1            |      5  1.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | I  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A   |  39        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  43        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  A   |  41        |
      Hyperplasia, Focal, Squamous         |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  43        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +     +              +                              |   3        |
      Dysplasia                            |                      2     3              2                              |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Thrombosis                           |                                                 X                        |      1     |
      Coronary Artery, Mineralization      |          1                                                               |      1  1.0|
      Myocardium, Fibrosis, Focal          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5|  |            |
                                           | 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6|  |      A     |
    6 MG/M3                                | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Spindle Cell, Hyperplasia            | 1  1  1  2  3  2  2  2  2  1  2  1  2  2        2        1  3  3     3   |     37  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Hyperplasia, Focal                   |                                                                   2      |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |          2                    3                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  I  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +   |  39        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | I  I  I  M  I  I  I  I  M  +  I  +  +  +  A  +  M  +  +  +  +  +  +  A   |  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  +  +  M  M  +  +  +  +  M  M  M  +  M  +  M  M  M  +  +  I   |  21        |
      Cyst                                 |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +   |  44        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +   |  46        |
      Cyst                                 |                               X                                          |      1     |
      Follicular Cell, Hyperplasia         |                                  2                                       |      8  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                           +                              |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  I  A  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  I  +  +   |  39        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                   +     +           +                  |   6        |
      Dilatation                           | 3                                   3     2           3                  |      6  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  43        |
      Inflammation, Suppurative            |                4                          3     3           4            |      7  3.4|
      Epithelium, Hyperplasia              |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  43        |
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  44        |
      Hypospermia                          |                      X                                            X      |      2     |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Seminiferous Tubule, Degeneration,   |                                                                          |            |
           Focal                           |                                  1                                       |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  +  A  +  +  +  A   |  42        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Myelofibrosis                        |                                                                          |      2  1.0|
      Myeloid Cell, Hyperplasia            |                3                          2                 3            |      7  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5|  |            |
                                           | 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6|  |      A     |
    6 MG/M3                                | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  3.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Pancreatic, Inflammation,            |                                                                          |            |
          Granulomatous                    |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +   |  39        |
      Hyperplasia, Histiocytic, Lymphoid   |                1                                                         |      1  1.0|
      Hyperplasia, Histiocytic             | 3  3  1  2        2  1     1  2  1              3  1     1  3  1     2   |     32  1.8|
      Hyperplasia, Lymphoid                |    1  1  4        2  2     1                                             |     10  1.6|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  M  +  +  +  M  +  +  +  M  +  M  M  +  +  M  +  M  M  M  +   |  23        |
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  +  M  M  M  +  M  M  M  M  +  +  M  M  M  M  M  M  M  M  +  +   |  10        |
      Hyperplasia, Histiocytic             |                                                                      2   |      1  2.0|
      Hyperplasia, Lymphoid                |          3                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M   |  39        |
      Hyperplasia, Lymphoid                |                                                    4                     |      3  3.0|
      Infiltration Cellular, Mixed Cell    | 2  3        3        2  3  2  2  2              1     1  3  3  1  2      |     20  2.3|
      Inflammation, Granulomatous          |          4                                                               |      1  4.0|
      Follicular, Necrosis                 | 2     2     2                          2                                 |      6  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  44        |
      Hematocyst                           |                      X                                                   |      1     |
      Hematopoietic Cell Proliferation     |          2     4                                   2        2            |      7  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Inflammation, Granulomatous          |          3                                                               |      1  3.0|
      Lymphoid Follicle, Depletion Lymphoid|                3                          1                              |      2  2.0|
      Lymphoid Follicle, Necrosis          |                         2                                   2            |      5  2.6|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  I  +  +  I  +  +  +  +  +  M  +  +  M  +  I  +  +  +  +  +  I  +   |  33        |
      Cyst                                 |                                                          X               |      2     |
      Inflammation, Granulomatous          |          3                                                               |      1  3.0|
      Cortex, Depletion Lymphoid           |                   3     3           2  2                 2  2        2   |     10  2.2|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  +  M  M  M  M  M  A   |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  45        |
      Abscess                              |                4                                                         |      1  4.0|
      Inflammation, Acute                  |                                     3                                    |      2  3.5|
      Ulcer, Focal                         |                                     3                                    |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| 7| 7| 5| 7| 2| 7| 5| 7| 7| 5| 6| 7| 7| 5|  |            |
                             DAY ON TEST   | 4| 3| 3| 3| 3| 8| 3| 3| 4| 4| 4| 3| 9| 2| 5| 3| 8| 1| 3| 9| 8| 4| 4| 5|  |            |
                                           | 0| 8| 8| 8| 8| 5| 8| 8| 6| 0| 0| 9| 1| 2| 3| 9| 4| 9| 9| 0| 1| 0| 0| 0|  |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 5| 5| 6| 6|  |      A     |
    6 MG/M3                                | 2| 3| 5| 6| 9| 0| 1| 5| 1| 4| 5| 7| 9| 2| 3| 5| 1| 4| 5| 6| 7| 8| 2| 4|  |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Mineralization, Focal                | 1     1        2  2  2  2  2  2     1  1  1  1  1  2  1  2  1  2  1  2   |     39  1.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  41        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Congestion                           |                                                                          |      1  3.0|
      Hyperplasia, Macrophage              | 2  1  2  2  2  1  3  1  1  1  2  2  1  1  1  1  2  1  1  2  1  1  2  1   |     46  1.4|
      Inflammation, Chronic Active         | 1     1     1        1        1                          1               |     16  1.1|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  46        |
      Cytoplasmic Alteration, Focal        | 3  1                       2  2  2                 1        1  1         |     23  1.8|
      Erosion, Focal                       |                                                                1         |      1  1.0|
      Inflammation, Acute                  |                                                                1         |      4  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  43        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A   |  46        |
      Hydronephrosis                       |                                                                          |      1  4.0|
      Inflammation, Focal, Suppurative     |                4                                4           2            |      5  3.6|
      Metaplasia, Focal, Osseous           |       1                    1                          1                  |      3  1.0|
      Pelvis, Inflammation, Suppurative    |                         4                 2                 3            |      5  3.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A   |  38        |
      Inflammation, Chronic Active         |                         3                 3                 4            |      5  3.2|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|             
                                           | 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|             
    18 MG/M3                               | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  M  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  A  M  +  +  +  A  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
      Dilatation                           |                                                                          |             
      Epithelium, Hyperplasia, Papillary   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  A  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
      Hyperplasia, Lymphoid                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  I  M  A  M  +  +  M  +  +  +  A  +  M  +  M  I  +  +  +  A  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  A  A  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  M  M  A  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         2|             
      Mucosa, Atrophy                      |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  A  +  +  +  A  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
      Hyperplasia, Lymphoid                |                                        4           4                     |             
      Mucosa, Atrophy                      |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  A  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +  +|             
      Hyperplasia, Lymphoid                |                                                    2                     |             
      Mucosa, Atrophy                      |                               2                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Focal Cellular Change                |                X     X                             X                 X   |             
      Inflammation, Focal                  |                            1                                             |             
      Necrosis, Focal                      |       2                                      2                           |             
      Pigmentation, Focal, Hemosiderin     |                                                                          |             
      Bile Duct, Hyperplasia, Focal        |          2                                                               |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  M  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Serosa, Inflammation, Suppurative    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Focal, Squamous         |                      1                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Spindle Cell, Hyperplasia            |    2     2     2  2  2     2  2  2  2  3  1  1  1  1  1           3     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Vacuolization Cytoplasmic, Focal     |                      1     1        2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|             
                                           | 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|             
    18 MG/M3                               | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  M  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | I  I  M  +  I  I  I  M  +  +  I  I  +  I  +  +  +  I  +  +  +  A  +  +  M|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  I  M  +  +  I  M  +  M  +  M  +  +  +  M  +  +  +  +  +  A  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Cyst                                 |                            X                                             |             
      Follicular Cell, Hyperplasia         |                      1              1                             2  2  1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                     +                                    |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                       +                    +                       +   |             
      Dilatation                           | 3                       2                    3                       3   |             
      Inflammation                         |                                                                      4   |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Suppurative            |          3                                4           4                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +|             
      Inflammation, Suppurative            |                                           4                              |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Aspermatogenesis, Diffuse            |                                        4                                 |             
      Atrophy, Diffuse                     |                                        4                                 |             
      Seminiferous Tubule, Degeneration,   |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia                          |                               2                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Renal, Depletion Lymphoid            |                                           3                              |             
      Renal, Hyperplasia, Lymphoid         |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Abscess                              |                                                                          |             
      Hyperplasia, Histiocytic             |    2  3  1     4  4  4     3  2  3  2  2  2  2  2  3  2  1  3     3  4  4|             
      Hyperplasia, Lymphoid                |    2                       3  3  2     3                 3  4        1   |             
      Infiltration Cellular, Mixed Cell    |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | I  +  +  M  M  +  +  M  I  M  M  M  +  M  M  +  +  M  M  I  M  M  +  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Follicular, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  M  M  M  M  M  M  M  M  M  M  +  M  M  M  +  M  +  M  M  M  M  M  M|             
      Hyperplasia, Histiocytic             |                                     3           2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|             
                                           | 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|             
    18 MG/M3                               | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +|             
      Depletion Lymphoid                   | 2                       3                                                |             
      Hyperplasia, Lymphoid                |                                                 2  4                    2|             
      Infiltration Cellular, Mixed Cell    |    2                 4     2  2        3              2                 2|             
      Thrombosis                           |                                                                          |             
      Follicular, Necrosis                 |                                              2                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hematopoietic Cell Proliferation     |       2        4     2                       2                           |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Hyperplasia, Mast Cell               |                                                                   3      |             
      Lymphoid Follicle, Depletion Lymphoid| 1                                         3                              |             
      Lymphoid Follicle, Necrosis          |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  M|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Necrosis                             |             1                                                            |             
      Cortex, Depletion Lymphoid           |             3           3           2     2                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | I  M  +  M  I  M  M  M  M  M  M  M  M  M  +  M  +  M  M  I  M  M  +  +  I|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization, Focal                |    3  2  2     1  1  1     2  1  2  1  2     2     2  2  1  1  2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Acute                  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Macrophage              | 1  3  3  3  1  3  3  3  1  3  3  3  3  3  3  2  3  3  3  3  3  3  3  3  3|             
      Inflammation, Chronic Active         |    3  2  2     2  2  2     2  3  2  2  3     2  2  2  2  3  3     2  1  2|             
      Thrombosis                           |                                                    X                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Cytoplasmic Alteration, Focal        |    3  1  1     4  4  4     3  4  4  1  4        1  2  3  1  1     1  1  3|             
      Erosion, Focal                       |                                                 1           1            |             
      Inflammation, Acute                  |                      1           1     1        1           1           1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  I  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 7| 5| 4| 0| 7| 7| 7| 1| 7| 7| 7| 7| 7| 4| 4| 7| 7| 6| 7| 7| 5| 7| 7| 7|             
                             DAY ON TEST   | 1| 3| 3| 3| 2| 3| 3| 3| 1| 3| 3| 3| 2| 4| 7| 5| 3| 3| 7| 3| 3| 5| 3| 3| 3|             
                                           | 4| 6| 8| 8| 8| 6| 6| 6| 5| 6| 6| 6| 4| 0| 8| 7| 7| 7| 2| 7| 7| 4| 7| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 5| 5| 5|             
    18 MG/M3                               | 3| 4| 5| 6| 7| 9| 2| 3| 5| 1| 3| 4| 5| 7| 9| 1| 3| 4| 1| 2| 8| 9| 0| 1| 2|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                               +  +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Focal, Suppurative     |          3                                                               |             
      Nephropathy, Chronic                 |       2                                   4                              |             
      Capsule, Inflammation, Suppurative   |                                                                          |             
      Pelvis, Inflammation, Suppurative    |          2                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
      Inflammation, Chronic Active         |          3                                3                              |             
      Ulcer, Focal                         |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3|            |
                                           | 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4|      A     |
    18 MG/M3                               | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  I  A  +     +  M  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  35        |
      Dilatation                           |          3                                                               |      1  3.0|
      Epithelium, Hyperplasia, Papillary   |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  A  +     A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  37        |
      Hyperplasia, Lymphoid                |                                                 3           3            |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  A  M     A  A  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +|  31        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  36        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  M  +  A  +|  34        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Mucosa, Atrophy                      |                               2  4                                       |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  35        |
      Hyperplasia, Lymphoid                |    2                                                           3  2      |      5  3.0|
      Mucosa, Atrophy                      |    2                          3  4                                       |      4  2.8|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +     A  A  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  36        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Mucosa, Atrophy                      |                                  4                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess                              |                                  4                                       |      1  4.0|
      Focal Cellular Change                |                                        X                                 |      5     |
      Inflammation, Focal                  |                                                                          |      1  1.0|
      Necrosis, Focal                      |          3        2                                                      |      4  2.3|
      Pigmentation, Focal, Hemosiderin     |          3                                                               |      1  3.0|
      Bile Duct, Hyperplasia, Focal        |                                                                          |      1  2.0|
      Serosa, Inflammation, Suppurative    |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  A  +     A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Serosa, Inflammation, Suppurative    |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia, Focal, Squamous         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +     A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3|            |
                                           | 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4|      A     |
    18 MG/M3                               | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Spindle Cell, Hyperplasia            | 2  2           2  1  1     2  2     1  2        2  2  1  2  2  1  2  1  2|     35  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Vacuolization Cytoplasmic, Focal     |                                                             2            |      4  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +     +  +  M  A  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  A  M     A  A  M  A  M  +  +  I  I  +  I  +  +  +  +  +  I  M  +  +|  24        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  M     M  +  +  A  M  M  M  M  M  +  M  +  +  M  +  +  +  M  +  +|  26        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  A  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Cyst                                 |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |    2                 3                             1                     |      8  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                 +                        |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     A  +  +  A  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M|  42        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                               +           +                    +  +      |   8        |
      Dilatation                           |                               3           3                    2  3      |      8  2.8|
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  44        |
      Inflammation, Suppurative            |                3                                                         |      4  3.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  I  A  +     A  A  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  39        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     A  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Aspermatogenesis, Diffuse            |                                                                          |      1  4.0|
      Atrophy, Diffuse                     |                                                                          |      1  4.0|
      Seminiferous Tubule, Degeneration,   |                                                                          |            |
           Focal                           |                                                                   1      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  A  +     +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Renal, Depletion Lymphoid            |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3|            |
                                           | 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4|      A     |
    18 MG/M3                               | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +     +  +  +  A  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|  44        |
      Abscess                              |                                  2                                       |      1  2.0|
      Hyperplasia, Histiocytic             | 4  2  3  3     4  3  1     2  2  2  1  3     2  3  1  2     2  3  4  2  2|     42  2.5|
      Hyperplasia, Lymphoid                | 3                    3     3  3  3  4  3     2  2  3  4     4  3  1     3|     23  2.8|
      Infiltration Cellular, Mixed Cell    |       3           2                                                      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  +     M  M  M  A  M  M  +  M  +  +  M  +  +  M  +  M  M  +  +  M|  19        |
      Hyperplasia, Lymphoid                |                                                          2               |      1  2.0|
      Follicular, Necrosis                 |                                           1                              |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +     M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M|   7        |
      Hyperplasia, Histiocytic             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | I  +  +  +     A  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M|  40        |
      Depletion Lymphoid                   |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                  3              2     3                  |      6  2.7|
      Infiltration Cellular, Mixed Cell    |       3  3                 2  3     2                    2               |     13  2.5|
      Thrombosis                           |                   X                                                      |      1     |
      Follicular, Necrosis                 |                                  3                                       |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hematopoietic Cell Proliferation     |       3  3     2  2              3              2                        |     10  2.5|
      Hyperplasia, Lymphoid                |                            2                 4                           |      3  2.7|
      Hyperplasia, Mast Cell               |                                                                          |      1  3.0|
      Lymphoid Follicle, Depletion Lymphoid|       2                          3        3                              |      5  2.4|
      Lymphoid Follicle, Necrosis          |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +  +  I  +  +|  40        |
      Cyst                                 |                                                       X                  |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Necrosis                             |                                  2                                       |      2  1.5|
      Cortex, Depletion Lymphoid           |       1        2  2                                                  3   |      8  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  +     M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M|   8        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Alopecia                             |                                           X                              |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 6| 7| 6| 7| 4| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 3| 2| 2| 5| 3| 2| 3| 3| 2| 4| 3| 5| 4| 4| 3| 3| 3| 3| 3| 3| 2| 3|            |
                                           | 0| 0| 1| 8| 2| 1| 8| 8| 2| 8| 8| 5| 0| 8| 9| 0| 0| 9| 9| 9| 9| 9| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      T     |
                               ANIMAL ID   | 5| 5| 7| 7| 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 3| 3| 4| 4|      A     |
    18 MG/M3                               | 3| 5| 7| 9| 1| 2| 3| 4| 5| 3| 4| 6| 7| 8| 0| 1| 3| 2| 3| 4| 7| 8| 9| 3| 5|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization, Focal                | 2  2  2  2     2  2  1     2  2  1  1  2  1     2  2  2  2              2|     38  1.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +     A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Congestion                           |                   2                                                      |      1  2.0|
      Hyperplasia, Macrophage              | 3  3  3  3     3  3  2     3  3  3  3  3  1  3  3  3  3  3  3  3  3  3  3|     48  2.8|
      Inflammation, Chronic Active         | 3  2  3  3     1     1     2  2  2  3  3     2  2  2  3  2  3  2  2     2|     40  2.2|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cytoplasmic Alteration, Focal        | 3  2  2  3     2     3     3  1  3  3  2     1  3  4  3  2  3  4  3  2  3|     40  2.5|
      Erosion, Focal                       |                                                                          |      2  1.0|
      Inflammation, Acute                  |                                           1                              |      7  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     A  M  M  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +                                       |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Focal, Suppurative     |                1        4                                                |      3  2.7|
      Nephropathy, Chronic                 |                                                                          |      2  3.0|
      Capsule, Inflammation, Suppurative   |                                  2                                       |      1  2.0|
      Pelvis, Inflammation, Suppurative    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     A  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  43        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Ulcer, Focal                         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 1| 1| 1| 7| 7| 5| 3| 3| 3| 7| 3| 7| 2| 1| 7| 7| 3| 6| 1| 5|             
                             DAY ON TEST   | 3| 4| 1| 3| 4| 8| 8| 8| 3| 3| 4| 6| 6| 6| 3| 6| 3| 9| 8| 3| 3| 6| 1| 8| 4|             
                                           | 9| 9| 5| 9| 9| 5| 5| 5| 9| 9| 9| 9| 8| 9| 9| 8| 9| 5| 5| 9| 9| 9| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 6| 6|             
    CONTROL                                | 2| 3| 5| 6| 8| 9| 3| 4| 7| 9| 0| 1| 4| 2| 8| 9| 0| 2| 3| 3| 6| 7| 9| 0| 1|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +           +     +           M     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +           +     +           +     I                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Pancreas                                |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +           +     +           +     +                       +     +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +           M     M           M     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +           +     M           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +           +     M           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                  +     +                       +         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Prostate                                |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +           M     M           +     +                       +     M  +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +           +     M           +     +                       M     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +           +     +           M     M                       +     M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 7| 5| 1| 1| 1| 7| 7| 5| 3| 3| 3| 7| 3| 7| 2| 1| 7| 7| 3| 6| 1| 5|             
                             DAY ON TEST   | 3| 4| 1| 3| 4| 8| 8| 8| 3| 3| 4| 6| 6| 6| 3| 6| 3| 9| 8| 3| 3| 6| 1| 8| 4|             
                                           | 9| 9| 5| 9| 9| 5| 5| 5| 9| 9| 9| 9| 8| 9| 9| 8| 9| 5| 5| 9| 9| 9| 9| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 7| 9| 9| 9| 0| 0| 0| 2| 2| 2| 3| 3| 3| 5| 5| 5| 5| 6| 6|             
    CONTROL                                | 2| 3| 5| 6| 8| 9| 3| 4| 7| 9| 0| 1| 4| 2| 8| 9| 0| 2| 3| 3| 6| 7| 9| 0| 1|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    +           M     M           +     M                       M     +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +           +     M           +     +                       +     M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +           M     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +           +     M           M     M                       M     M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +           +     +           +     +                       +     +  +|             
      Mineralization, Focal                |                                                                2        1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Lung                                    |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Nose                                    |    +           +     +           +     +                       +     +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +           +     +           +     +                       +     +  +|             
      Inflammation, Chronic Active, Focal  |                                                                2         |             
      Cortex, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +           +     +           +     +                       +     +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7|                                |            |
                             DAY ON TEST   | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3|                                |            |
                                           | 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|                                |      T     |
                               ANIMAL ID   | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2|                                |      A     |
    CONTROL                                | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4|                                |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +        +  +              +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +        +  +              M                                          |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +        +  +              +                                          |  12        |
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +        +  +              +                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +        +  +              +                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +        +  I              +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +        +  I              +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +        M  +              +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M        M  +              M                                          |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +        +  +              +                                          |  11        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +        +  +              +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +        M  +              +                                          |   8        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +        +  +              +                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 5| 1| 1| 5| 7| 0| 1| 7| 5| 5| 3| 7|                                |            |
                             DAY ON TEST   | 6| 6| 5| 8| 8| 4| 3| 3| 8| 3| 4| 5| 6| 3|                                |            |
                                           | 9| 9| 0| 6| 7| 9| 9| 9| 7| 9| 9| 0| 9| 9|                                |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                |      O     |
   B6C3F1 MICE MALE                        | 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|                                |      T     |
                               ANIMAL ID   | 6| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 2| 2|                                |      A     |
    CONTROL                                | 2| 1| 3| 6| 7| 0| 1| 5| 1| 4| 6| 9| 2| 4|                                |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +        +  +              M                                          |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +  M              M                                          |   6        |
      Hyperplasia, Lymphoid                |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +        M  M              M                                          |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +        +  +              +                                          |  10        |
      Hyperplasia, Lymphoid                |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +        +  +              +                                          |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M        M  M              +                                          |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +        +  +              +                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +        +  +              +                                          |  12        |
      Mineralization, Focal                |    2           2              2                                          |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +        +  +              +                                          |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +        +  +              +                                          |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +        +  +              +                                          |  12        |
      Inflammation, Chronic Active, Focal  |                                                                          |      1  2.0|
      Cortex, Cyst                         |                X                                                         |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +        +  +              +                                          |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 1| 7| 7| 1| 5| 3| 7| 3| 5| 1| 7| 5| 3| 1| 5| 3| 7| 5| 5| 3| 5| 7| 1|             
                             DAY ON TEST   | 7| 6| 8| 3| 3| 8| 4| 6| 3| 6| 4| 8| 3| 4| 6| 8| 4| 6| 3| 4| 5| 6| 4| 3| 8|             
                                           | 6| 9| 5| 9| 9| 5| 9| 8| 9| 9| 9| 5| 9| 9| 8| 5| 9| 9| 9| 9| 0| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| 9| 0|             
    6 MG/M3                                | 2| 3| 6| 9| 1| 2| 3| 1| 4| 7| 9| 3| 4| 5| 2| 3| 7| 9| 0| 3| 1| 4| 7| 8| 2|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +           +        +     +     M           M     +        +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +           +        +     +     +           +     M        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +           +        +     +     +           +     M        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  M           M        +     +     +           +     +        +     +|             
      Spindle Cell, Hyperplasia            |                                                          1        1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  M           M        +     +     +           +     +        +     +|             
      Hyperplasia, Focal                   |                                        3                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  M           M        +     +     M           +     +        +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    M  +           +        +     +     M           M     +        +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  M           +        M     M     M           M     M        +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +           +        M     +     +           I     +        M     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |    +                       +                       +                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  M           +        +     M     +           +     +        +     M|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +           +        +     +     +           +     +        +     +|             
      Myelofibrosis                        |                                        1                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 3| 1| 7| 7| 1| 5| 3| 7| 3| 5| 1| 7| 5| 3| 1| 5| 3| 7| 5| 5| 3| 5| 7| 1|             
                             DAY ON TEST   | 7| 6| 8| 3| 3| 8| 4| 6| 3| 6| 4| 8| 3| 4| 6| 8| 4| 6| 3| 4| 5| 6| 4| 3| 8|             
                                           | 6| 9| 5| 9| 9| 5| 9| 8| 9| 9| 9| 5| 9| 9| 8| 5| 9| 9| 9| 9| 0| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 6| 6| 6| 6| 7| 7| 9| 9| 9| 9| 0|             
    6 MG/M3                                | 2| 3| 6| 9| 1| 2| 3| 1| 4| 7| 9| 3| 4| 5| 2| 3| 7| 9| 0| 3| 1| 4| 7| 8| 2|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    M  +           +        I     I     +           +     +        +     +|             
      Hyperplasia, Histiocytic             |                                        1           1     1        2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    M  +           +        +     +     M           +     +        +     +|             
      Hyperplasia, Histiocytic             |                                                          2               |             
      Hyperplasia, Lymphoid                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    M  M           +        M     M     +           M     M        +     M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +           +        +     M     M           +     +        +     M|             
      Hyperplasia, Histiocytic             |                                                          2        3      |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +           +        +     +     +           +     +        +     +|             
      Hyperplasia, Lymphoid                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +           +        +     +     +           M     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  M           M        +     M     M           M     M        M     M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +           +        +     +     +           +     +        +     +|             
      Mineralization, Focal                |                                                    1     1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +           +        +     +     +           +     +        +     +|             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +           +        +     +     +           +     +        +     +|             
      Hyperplasia, Macrophage              |    1  1           1        1     1     1           1     1        2      |             
      Alveolus, Mineralization, Focal      |                                  1                                       |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +           +        +     +     +           +     +        +     +|             
      Cytoplasmic Alteration, Focal        |                                        1                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   A      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +           +        +     +     +           +     +        +     +|             
      Inflammation, Chronic Active, Focal  |                            1                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +           +        +     +     +           +     +        +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1|                             |            |
                             DAY ON TEST   | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8|                             |            |
                                           | 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      T     |
                               ANIMAL ID   | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6|                             |      A     |
    6 MG/M3                                | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +        +                                                   |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             +        +                                                   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +        +                                                   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |             +        +                                                   |  10        |
      Spindle Cell, Hyperplasia            |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |             +        +                                                   |  10        |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |             +        +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +        +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             +        +                                                   |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |             +        +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                                                            |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Prostate                                |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +        M                                                   |   8        |
                                            __________________________________________________________________________|____________|
   Testes                                  |             +        +                                                   |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1|                             |            |
                             DAY ON TEST   | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8|                             |            |
                                           | 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      T     |
                               ANIMAL ID   | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6|                             |      A     |
    6 MG/M3                                | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +        +                                                   |  12        |
      Myelofibrosis                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |             +        +                                                   |   9        |
      Hyperplasia, Histiocytic             |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |             +        M                                                   |   9        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |             +        M                                                   |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |             +        +                                                   |   9        |
      Hyperplasia, Histiocytic             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  |             +        +                                                   |  12        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             +        +                                                   |  11        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             +        M                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +        +                                                   |  12        |
      Mineralization, Focal                |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |             +        +                                                   |  12        |
                                            __________________________________________________________________________|____________|
   Lung                                    |             +        +                                                   |  12        |
      Hyperplasia, Macrophage              |             1        1                                                   |     11  1.1|
      Alveolus, Mineralization, Focal      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +        +                                                   |  12        |
      Cytoplasmic Alteration, Focal        |             1                                                            |      2  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +        +                                                   |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 1| 7| 3| 7| 5| 1| 5| 3| 6| 3| 7| 7| 1|                             |            |
                             DAY ON TEST   | 1| 7| 8| 3| 6| 3| 5| 8| 5| 6| 7| 7| 3| 1| 8|                             |            |
                                           | 7| 6| 6| 9| 9| 9| 0| 7| 4| 9| 2| 6| 9| 8| 7|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |      T     |
                               ANIMAL ID   | 0| 0| 2| 2| 2| 2| 3| 3| 3| 5| 5| 5| 6| 6| 6|                             |      A     |
    6 MG/M3                                | 3| 4| 2| 3| 6| 8| 0| 1| 4| 2| 3| 9| 1| 3| 5|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |             +        +                                                   |  12        |
      Inflammation, Chronic Active, Focal  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +        +                                                   |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 1| 1| 1| 7| 3| 5| 1| 3| 5| 1| 5| 5| 1| 7| 5| 7| 3| 1| 1| 1| 7| 5|             
                             DAY ON TEST   | 1| 4| 4| 1| 1| 8| 3| 6| 4| 8| 6| 4| 8| 6| 4| 8| 3| 5| 3| 6| 8| 4| 8| 3| 4|             
                                           | 3| 9| 9| 4| 4| 7| 9| 8| 9| 5| 8| 9| 5| 9| 9| 6| 9| 0| 9| 9| 6| 8| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 9| 9| 9| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 7| 7| 7|             
    18 MG/M3                               | 1| 2| 8| 0| 1| 4| 2| 6| 8| 0| 2| 5| 3| 4| 5| 6| 7| 4| 1| 2| 3| 4| 5| 6| 8|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +                             +     +  +           M  +           +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +                             +     +  +           +  +           M|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +                             +     +  +           +  +           +|             
      Focal Cellular Change                |                                                          4               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +                             +     +  +           +  +           +|             
      Spindle Cell, Hyperplasia            |    1  2                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +                             +     +  +           M  +           +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  M                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +                             +     M  M           M  M           M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +                             M     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +                             +     +  +           M  +           +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                          +              +|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +                             M     +  M           +  M           +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |    +  +                             +     +  +           M  +           +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 1| 1| 1| 7| 3| 5| 1| 3| 5| 1| 5| 5| 1| 7| 5| 7| 3| 1| 1| 1| 7| 5|             
                             DAY ON TEST   | 1| 4| 4| 1| 1| 8| 3| 6| 4| 8| 6| 4| 8| 6| 4| 8| 3| 5| 3| 6| 8| 4| 8| 3| 4|             
                                           | 3| 9| 9| 4| 4| 7| 9| 8| 9| 5| 8| 9| 5| 9| 9| 6| 9| 0| 9| 9| 6| 8| 6| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 9| 9| 9| 1| 1| 1| 2| 2| 2| 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 7| 7| 7|             
    18 MG/M3                               | 1| 2| 8| 0| 1| 4| 2| 6| 8| 0| 2| 5| 3| 4| 5| 6| 7| 4| 1| 2| 3| 4| 5| 6| 8|             
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Histiocytic             |    4  3                             1     3                             2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  M                             +     M  M           M  M            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 |    M  M                             M     +  M           +  M           M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  M                             +     +  +           +  +           M|             
      Hyperplasia, Lymphoid                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  |    M  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M                             M     M  M           M  M           M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +                             +     +  +           +  +           +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +                             +     +  +           +  +           +|             
      Mineralization, Focal                |    2                                      1              1              2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +                             +     +  +           +  +           +|             
      Hyperplasia, Macrophage              |    2  3                             1     2  1           2  1           3|             
      Inflammation, Chronic Active         |    1  2                                                  1               |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +                             +     +  +           +  +           +|             
      Cytoplasmic Alteration, Focal        |    2                                      1                             1|             
      Cytoplasmic Alteration               |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +                             +     +  +           M  +           +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +                             +     +  +           +  +           +|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +                             +     +  +           +  +           +|             
      Lumen, Calculus Micro Observation    |                                                                          |             
          Only                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3|                             |            |
                             DAY ON TEST   | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6|                             |            |
                                           | 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE MALE                        | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |      T     |
                               ANIMAL ID   | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4|                             |      A     |
    18 MG/M3                               | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    M  +                    +           M                                 |   9        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    M  +                    +           +                                 |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +                    +           I                                 |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +                    +           +                                 |  12        |
      Focal Cellular Change                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +                    +           +                                 |  12        |
      Spindle Cell, Hyperplasia            |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +                    +           +                                 |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  M                    +           +                                 |   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +                    +           +                                 |  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M                    M           M                                 |   4        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +                    +           +                                 |  11        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +                    +           +                                 |  11        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                       +           +                                 |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +                       +           +                                 |   8        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +                    +           +                                 |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3|                             |            |
                             DAY ON TEST   | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6|                             |            |
                                           | 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE MALE                        | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |      T     |
                               ANIMAL ID   | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4|                             |      A     |
    18 MG/M3                               | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +                    M           +                                 |  10        |
      Hyperplasia, Histiocytic             |       1                                3                                 |      7  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  M                    M           +                                 |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    M  M                    +           M                                 |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +                    +           +                                 |  10        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +                    +           +                                 |  11        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M  M                    M           M                                 |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +                    +           +                                 |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +                    +           +                                 |  12        |
      Mineralization, Focal                |                                        1                                 |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +                    +           +                                 |  12        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +                    +           +                                 |  12        |
      Hyperplasia, Macrophage              |    1  1                    2           2                                 |     12  1.8|
      Inflammation, Chronic Active         |    3  1                                                                  |      5  1.6|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +                    +           +                                 |  12        |
      Cytoplasmic Alteration, Focal        |    1                       1           1                                 |      6  1.2|
      Cytoplasmic Alteration               |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +                    M           +                                 |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +                    +           +                                 |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05079-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:10:35  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 1| 7| 3| 7| 5| 6| 5| 3| 2| 5| 1| 3| 3|                             |            |
                             DAY ON TEST   | 3| 6| 8| 3| 6| 3| 5| 4| 5| 6| 1| 9| 8| 6| 6|                             |            |
                                           | 9| 9| 7| 9| 9| 9| 0| 6| 0| 9| 5| 4| 6| 9| 9|                             |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                             |      O     |
   B6C3F1 MICE MALE                        | 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                             |      T     |
                               ANIMAL ID   | 8| 0| 0| 0| 0| 1| 1| 1| 3| 3| 3| 4| 4| 4| 4|                             |      A     |
    18 MG/M3                               | 0| 1| 2| 5| 9| 2| 4| 5| 1| 5| 6| 0| 1| 2| 4|                             |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                             |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +                    +           +                                 |  12        |
      Lumen, Calculus Micro Observation    |                                                                          |            |
          Only                             |                                        X                                 |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
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