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TDMS Study 05079-01 Pathology Tables

NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  14807966

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|             
                             DAY ON TEST   | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|             
                                           | 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation                         |             2  2  3     1     1                                          |             
      Parasite Metazoan                    |                   X              X           X                 X  X      |             
      Ulcer                                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       X              X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
      Inflammation                         |                2              1                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis, Focal                      |                                                 3                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          4           2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          2        2  3           3  1  1  2  2        2  2  2  3        1|             
      Clear Cell Focus                     |                                                                   2      |             
      Cyst Multilocular                    |       X                                                                  |             
      Eosinophilic Focus                   |                                                                         1|             
      Fatty Change                         |                   1     2              3        3        2  4           2|             
      Hematopoietic Cell Proliferation     |                                              1                           |             
      Inflammation, Focal, Granulomatous   |                   1  1              1  2  1                    2  1  3   |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis, Focal                      |                      1                                                   |             
      Pigmentation, Hemosiderin            |                3                                                         |             
      Bile Duct, Hyperplasia               | 1  4     1  1  4  1  1  2  1  2  1  1  2  1        2  1  2        2  2   |             
      Centrilobular, Degeneration          |    4        4  4        4     3                    4                     |             
      Centrilobular, Necrosis              |                            3                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Granuloma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Nodular                 |                                  3                                       |             
      Lobules, Atrophy                     |             2        1                          1                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                          3              2|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                             3            |             
      Inflammation                         |                                                                          |             
      Ulcer                                |    4                                            3  2        4        3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|             
                             DAY ON TEST   | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|             
                                           | 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                               3                                          |             
      Mineralization                       | 2                                                           3            |             
      Ulcer                                |             3           3                                                |             
      Ulcer, Multiple                      |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +        +                                                      |             
      Mesenteric Artery, Aneurysm          |                                                                          |             
      Mesenteric Artery, Inflammation      |          3        3                                                      |             
      Mesenteric Artery, Thrombosis        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 3     1  2  1  2  2  2     1     1  2  2  2           2     2  2     2   |             
      Inflammation, Focal                  |                   2                                                      |             
      Atrium, Thrombosis                   |    X                    X     X                 X                        |             
      Myocardium, Mineralization           | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                    2                     |             
      Degeneration, Fatty                  |                                                             3            |             
      Degeneration, Focal                  |                                                                          |             
      Hyperplasia, Focal                   |                      3  1  2  2                 3                        |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          | 2     2     3     2  2  2  4  3                 1        2  3            |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                          3                        |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X     X                                                         |             
      Pars Distalis, Hyperplasia           |             2     3  2  3     2  2  3                             4      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |             1                    2     4        3     2  1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|             
                             DAY ON TEST   | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|             
                                           | 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |       2                                                                  |             
      Inflammation                         |          3                                                               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                       X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation                         |             2                                                            |             
      Endometrium, Hyperplasia             |                   4           3                                          |             
      Lamina Propria, Fibrosis             |                      2  1        1     1  2                    1  1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2                                                                     |             
      Hyperplasia, Histiocytic             |                                  4                                       |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Myelofibrosis                        |                               2                                          |             
      Myeloid Cell, Hyperplasia            |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                                     4                                    |             
      Inflammation, Suppurative            |                                                          2               |             
      Pigmentation, Hemosiderin            |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                2         |             
      Inflammation, Chronic Active         |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Chronic                  |                                                                          |             
      Hyperplasia, Lymphoid                |                                                             2            |             
      Inflammation, Suppurative            |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   3                                                      |             
      Hyperplasia, Plasma Cell             |                            3                                             |             
      Inflammation, Chronic Active         |          2                                      3        2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   3                                                      |             
      Fibrosis, Focal                      |                3  4     4                                                |             
      Hematopoietic Cell Proliferation     |                                  3           3  3                        |             
      Inflammation, Focal, Granulomatous   |                      2                                                   |             
      Pigmentation, Hemosiderin            |                3  3                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|             
                             DAY ON TEST   | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|             
                                           | 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | X                                               X                        |             
      Hyperostosis                         |                X  X                                      X               |             
      Pelvis, Fracture                     |                                                                          |             
      Vertebra, Cyst                       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                        X                    X        X   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Crystals, Focal                      |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Granulomatous          |                                  2  1                                    |             
      Inflammation, Suppurative            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  1                                       |             
      Bronchus, Epithelium, Degeneration,  |                                                                          |             
           Focal                           |                                                                          |             
      Interstitium, Fibrosis, Focal        |                                                          1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Nerve, Developmental Malformation    |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                            1                                         2   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                    +                                       |             
      Cataract                             |             3                    3                                       |             
      Retina, Degeneration                 |             4                    3                                       |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                +               |             
      Inflammation                         |                         2                                1               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 6| 8| 7| 5| 6| 7| 8| 7| 7| 7| 8| 8| 7| 8| 3| 8| 5| 7| 8| 8| 8| 5| 6| 6|             
                             DAY ON TEST   | 0| 4| 6| 1| 5| 8| 8| 6| 6| 1| 6| 6| 6| 7| 6| 7| 0| 6| 6| 2| 0| 4| 8| 2| 9|             
                                           | 8| 7| 2| 9| 8| 8| 9| 2| 8| 6| 7| 2| 2| 2| 2| 0| 5| 8| 6| 7| 0| 1| 4| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 2| 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 5| 6| 8| 1| 2| 6| 7| 8| 9| 0| 1| 2| 5| 6| 0| 1| 2| 5| 6| 7| 8| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                               2                                          |             
      Cyst, Multiple                       |                                                                          |             
      Infarct                              |                         3                                                |             
      Inflammation                         |                   2                                                      |             
      Nephropathy                          | 4     3     1  1  2  4  2  1  3  3  4  3  4     4  1  2  2  3  2  1  2  2|             
      Renal Tubule, Necrosis               |                2                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5|            |
                             DAY ON TEST   | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8|            |
                                           | 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    CONTROL                                | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  46        |
      Inflammation                         |       2              2                 2        1     3     2            |     11  1.9|
      Parasite Metazoan                    |                                           X                    X         |      7     |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +  M  +  +  M  +  +  +  +  +  M  M  +  +  +  M  +  +  +  A  A|  38        |
      Inflammation                         |                                                    1        3            |      4  1.8|
      Parasite Metazoan                    |                                  X                             X         |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Necrosis, Focal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  44        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | 3  3  1                 3     1     4  1  4  3     1  1     2  2        2|     27  2.1|
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Cyst Multilocular                    |                                                                          |      1     |
      Eosinophilic Focus                   |                                                          1               |      2  1.0|
      Fatty Change                         |    1  4  3        3  3     1                          3  2  2     4     2|     18  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Inflammation, Focal, Granulomatous   |                2  2     1                             3        1         |     13  1.6|
      Inflammation, Suppurative            |                                        3                                 |      1  3.0|
      Necrosis, Focal                      |       1  2                             2  1                              |      5  1.4|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |    2  2        2     2     1  1  1     1  1  1  3  2  1  2  3  1        1|     36  1.6|
      Centrilobular, Degeneration          |                                                 2  4     3  2            |     10  3.4|
      Centrilobular, Necrosis              |                                                                      1   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   1        |
      Granuloma                            |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Nodular                 |                                                                          |      1  3.0|
      Lobules, Atrophy                     |       1              1                 1              2                  |      7  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5|            |
                             DAY ON TEST   | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8|            |
                                           | 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    CONTROL                                | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                                                          |      1  3.0|
      Inflammation                         |                   1                                                      |      1  1.0|
      Ulcer                                |             3              3           3           3                     |      9  3.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      2  2.5|
      Ulcer                                |                                                             3            |      3  3.0|
      Ulcer, Multiple                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                       +                  |   3        |
      Mesenteric Artery, Aneurysm          |                                                       X                  |      1     |
      Mesenteric Artery, Inflammation      |                                                       3                  |      3  3.0|
      Mesenteric Artery, Thrombosis        |                                                       X                  |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  1        1  1  1  2  2  1  1     1  2  2  1  1  4     1  2  1      |     35  1.6|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Atrium, Thrombosis                   |                                                    X                     |      5     |
      Myocardium, Mineralization           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Degeneration, Fatty                  |          4                                                              2|      3  3.0|
      Degeneration, Focal                  |                                        1                                 |      1  1.0|
      Hyperplasia, Focal                   |                3              2                    2     2               |      9  2.2|
      Necrosis, Focal                      |                                                                      2   |      1  2.0|
      Pigmentation, Hemosiderin            |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                  2                                       |      1  2.0|
      Hyperplasia                          |             1        4        1        3        4     3        2  1     2|     20  2.4|
      Bilateral, Hyperplasia               |                                                    4     4               |      2  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  M  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +|  43        |
      Hyperplasia                          |                               2                                          |      3  2.3|
      Bilateral, Hyperplasia               |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5|            |
                             DAY ON TEST   | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8|            |
                                           | 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    CONTROL                                | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      2     |
      Pars Distalis, Hyperplasia           |                1                    2                                    |     10  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |    1                          1  2     2                                 |     10  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                    4                     |      2  3.0|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             X                 3                          X               |      5  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                       X                  |      1     |
      Inflammation                         |                                                                          |      1  2.0|
      Endometrium, Hyperplasia             |                      1                                                   |      3  2.7|
      Lamina Propria, Fibrosis             |    1  1        2  1     1  1  2  2           2        1     1  2        1|     20  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  4.0|
      Inflammation, Focal, Granulomatous   |                                                                2         |      1  2.0|
      Myelofibrosis                        |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                  2                                       |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Plasma Cell             |                                                       3                  |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage, Chronic                  |                                                          2               |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5|            |
                             DAY ON TEST   | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8|            |
                                           | 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    CONTROL                                | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                        3                                 |      2  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                    2                     |      4  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                   3                                                      |      2  3.0|
      Fibrosis, Focal                      |                                                                          |      3  3.7|
      Hematopoietic Cell Proliferation     |                                                                         3|      4  3.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Focal                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |             X                          X                                 |      4     |
      Hyperostosis                         |    X                                                                     |      4     |
      Pelvis, Fracture                     |          X                                                               |      1     |
      Vertebra, Cyst                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |    X                       X                    X     X           X      |      8     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                             1            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Crystals, Focal                      |                                                    3                     |      1  3.0|
      Edema                                |                   3                                                      |      1  3.0|
      Inflammation, Granulomatous          |                                                                          |      2  1.5|
      Inflammation, Suppurative            |       4                                3                                 |      2  3.5|
      Alveolar Epithelium, Hyperplasia     |    1                                                                     |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 6| 3| 8| 8| 7| 8| 6| 7| 8| 8| 6| 8| 7| 8| 7| 8| 8| 7| 8| 8| 5| 3| 5|            |
                             DAY ON TEST   | 1| 3| 7| 9| 6| 6| 6| 2| 3| 3| 6| 6| 7| 4| 2| 6| 7| 5| 1| 8| 1| 6| 9| 9| 8|            |
                                           | 6| 5| 7| 8| 3| 3| 2| 4| 4| 1| 3| 3| 8| 6| 7| 3| 9| 9| 3| 6| 7| 3| 9| 0| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    CONTROL                                | 3| 4| 6| 7| 0| 1| 2| 3| 4| 7| 9| 0| 2| 3| 6| 7| 8| 2| 4| 5| 7| 8| 9| 0| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Bronchus, Epithelium, Degeneration,  |                                                                          |            |
           Focal                           |                            3                                             |      1  3.0|
      Interstitium, Fibrosis, Focal        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  48        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                               2                                          |      1  2.0|
      Nerve, Developmental Malformation    |                                                          2               |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                             2            |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      2  3.0|
      Retina, Degeneration                 |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                    +                       +      |   5        |
      Inflammation                         |                      4                    2                              |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Abscess                              |                                                                          |      1  2.0|
      Cyst, Multiple                       |                         X                                                |      1     |
      Infarct                              |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
      Nephropathy                          | 1  3  1     4  2  1  3  1  2  4  4     4  1  3  2  3  3  3  2  3  3     1|     44  2.5|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|             
                             DAY ON TEST   | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|             
                                           | 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|             
    6 MG/M3                                | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  A  +  +  A  A  +  +  +  +  A  +  A  +  +  A  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation                         |                                                                          |             
      Parasite Metazoan                    |                X                                   X                     |             
      Ulcer                                |                   3                                                      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  A  +  +  A  A  +  +  +  +  A  +  +  +  +  A  +  +  +|             
      Inflammation                         |                                                             2            |             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  +  M  +  +  +  M  +  M  M  +  A  +  +  +  +  M  +  +  +|             
      Parasite Metazoan                    |                               X                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  A  +  +  +  +  A  +  +  A  A  +  +  +  +  A  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  A  +  +  A  A  +  +  +  +  A  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                3  1                    2           1  2  4  2            |             
      Clear Cell Focus                     |    1                                                                     |             
      Degeneration, Cystic                 |                                        3           1                     |             
      Eosinophilic Focus                   |             2                                                            |             
      Fatty Change                         |                         4        4  1  4  4           3              4   |             
      Inflammation, Focal, Granulomatous   |          2              2                                                |             
      Inflammation, Focal, Necrotizing     |    3                                                                     |             
      Necrosis, Focal                      |                               3                                          |             
      Bile Duct, Hyperplasia               | 2  1        1  1  1  2  1     2     1  3  3  2     1        2  4  3     1|             
      Centrilobular, Atrophy               |             2                                                            |             
      Centrilobular, Degeneration          |                               4           3                 4  3  4     4|             
      Centrilobular, Necrosis              | 3     4                                                                  |             
      Serosa, Thrombosis                   | X     X                                                        X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                   +                  |             
      Granuloma                            |                                                       3                  |             
      Inflammation, Chronic Active         |                   4                                                      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Lobules, Atrophy                     | 1  4              4     1                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Ulcer                                |                                                                   2     3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|             
                             DAY ON TEST   | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|             
                                           | 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|             
    6 MG/M3                                | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |                                  4                                       |             
      Ulcer                                |                               3                                          |             
      Arteriole, Muscularis, Lamina        |                                                                          |             
          Propria, Mineralization          |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                  +                                       |             
      Aorta, Mineralization                |                                  4                                       |             
      Mesenteric Artery, Mineralization    |                                  4                                       |             
      Mesenteric Artery, Thrombosis        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  3  1  2  1  1  2  2     2  2  1     1  2     1  1  1  1  1  1     1|             
      Atrium, Thrombosis                   | X     X                       X        X  X                    X         |             
      Myocardium, Embolus                  |                                        2                                 |             
      Myocardium, Inflammation, Focal      |                               3                                          |             
      Myocardium, Mineralization           |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  |                                                                          |             
      Hyperplasia, Diffuse                 |                                                             1            |             
      Hyperplasia, Focal                   |          3                    2           2           2           3      |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1     1        1  1                 2  2        2  4           1     2|             
      Bilateral, Hyperplasia               |       4                          4                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  I  +  +  +|             
      Hyperplasia                          |                                  4                                      2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    1           2                       2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2  2           1  2                       2                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  M  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|             
                             DAY ON TEST   | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|             
                                           | 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|             
    6 MG/M3                                | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
      Inflammation                         |                   4                                                      |             
      Lamina Propria, Fibrosis             | 1  2  1  2  1  1        2  2  1     1  1  1  1  1     1  1  1     1  1  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +|             
      Atrophy                              |                               3                       3                  |             
      Myelofibrosis                        |                                                          2               |             
      Necrosis, Focal                      |                                                                          |             
      Myeloid Cell, Hyperplasia            |                   3                    3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hemorrhage, Chronic                  |                   2                                                      |             
      Hyperplasia, Histiocytic             | 2  1     1  2  2  2     2  2        2  4     2     2  3  2  2  2  2  2  3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                         2                                                |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  A  M  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             | 3  2     2  3  2        2  2     3  2        2        3     2  3  2  1   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                3         |             
      Inflammation, Chronic Active         |                   3                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3                                         2|             
      Fibrosis, Focal                      |                                        4                                 |             
      Hematopoietic Cell Proliferation     |                   4              3                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                          X               |             
      Hyperplasia, Cystic                  |          4                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                  X                                       |             
      Hyperostosis                         |                               X                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 7| 7| 8| 4| 7| 7| 5| 8| 6| 8| 5| 8| 7| 8| 8| 7| 5| 5| 7|             
                             DAY ON TEST   | 1| 6| 6| 6| 6| 6| 6| 9| 1| 8| 4| 2| 6| 4| 9| 6| 0| 6| 6| 4| 1| 6| 2| 6| 0|             
                                           | 2| 2| 6| 2| 2| 2| 2| 8| 5| 2| 7| 0| 6| 1| 0| 2| 8| 2| 8| 9| 8| 0| 6| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 3| 4| 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 6| 6| 7|             
    6 MG/M3                                | 4| 6| 7| 8| 0| 1| 3| 4| 7| 8| 9| 0| 3| 4| 5| 7| 8| 2| 3| 4| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Compression                          |          3  X           4           4     X                              |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Focal                  |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Granulomatous          | 2  2  2  1  2  2  1     2  1  2  1  1  2  1  1     2  2  2  2  1  1  2  1|             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                  3                                       |             
      Alveolar Epithelium, Hyperplasia     | 1  2     1  2  1  1     1  1        1  2     1     2     1  1        1  1|             
      Interstitium, Fibrosis, Focal        | 1           1                 2        4     1     4     1  1           1|             
      Interstitium, Mineralization         |                                                                          |             
      Peribronchial, Hyperplasia,          |                                                                          |             
          Histiocytic                      |    1     1  1  2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  4                                       |             
      Mucosa, Inflammation, Suppurative    |             3                                                  3         |             
      Olfactory Epithelium, Metaplasia     |             4                                                            |             
      Respiratory Epithelium, Hyperplasia  |             1                                                            |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +  +                                         +            |             
      Inflammation                         |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Embolus, Multiple                    |                                                                          |             
      Inflammation                         |                               3                                          |             
      Nephropathy                          | 3  3  1  3  3  2  2     3     2  4  3  1  1  3     2  4  4  3  2  1  1  4|             
      Capsule, Inflammation                |                   3                                                      |             
      Medulla, Inflammation                |                                        3                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8|            |
                                           | 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4|      A     |
    6 MG/M3                                | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  A  +  A  +  A  +  A  +  A  +  +  +  +  +  A  +  +  A  A|  34        |
      Hemorrhage, Focal                    |                                                 3                        |      1  3.0|
      Inflammation                         |                                              3                           |      1  3.0|
      Parasite Metazoan                    |                                                                X         |      3     |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  41        |
      Inflammation                         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                            X                       X                     |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  M  +  M  +  A  +  +  +  A  +  M  +  +  +  +  +  +  +  +|  37        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  A  +  A  +  +  +  A  M  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +  A  +  A  A  A  +  +  +  A  +  A  +  +  +  A  +  +  A  A|  32        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                2                                                         |      1  2.0|
      Basophilic Focus                     | 3  2           1                 3     2           1  1  1           1  2|     17  1.9|
      Clear Cell Focus                     | 1                                                                        |      2  1.0|
      Degeneration, Cystic                 |                                                                          |      2  2.0|
      Eosinophilic Focus                   |                            2     3  1                          1         |      5  1.8|
      Fatty Change                         |             4     4  4     1  4           1  3           1  2     3  3   |     18  3.0|
      Inflammation, Focal, Granulomatous   |                                                 2                        |      3  2.0|
      Inflammation, Focal, Necrotizing     |                                                                          |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 1  1  1        1  2  1     3  3  1  1  1  2  3  2  1  1     2  2  3  4  2|     38  1.8|
      Centrilobular, Atrophy               |                                                                   3      |      2  2.5|
      Centrilobular, Degeneration          |             4     4  4        4           3  4              4        4   |     14  3.8|
      Centrilobular, Necrosis              |                                                                          |      2  3.5|
      Serosa, Thrombosis                   |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Granuloma                            |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation                         |                   3                                                      |      1  3.0|
      Lobules, Atrophy                     |       3              1                          1                        |      7  2.1|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8|            |
                                           | 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4|      A     |
    6 MG/M3                                | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
      Mineralization                       |    3                                                                     |      1  3.0|
      Ulcer                                |                1                                                        4|      4  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation                         |                                                                      2   |      1  2.0|
      Mineralization                       |    3                                                                     |      2  3.5|
      Ulcer                                |                                                             1            |      2  2.0|
      Arteriole, Muscularis, Lamina        |                                                                          |            |
          Propria, Mineralization          |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                             +            |   2        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                 +                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +                                                                  |   3        |
      Aorta, Mineralization                |    3  4                                                                  |      3  3.7|
      Mesenteric Artery, Mineralization    |                                                                          |      1  4.0|
      Mesenteric Artery, Thrombosis        |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cardiomyopathy                       | 1  1        1  1  1        2  4  2  2  2  1  1     2  1  1  1  1  1  1  1|     40  1.4|
      Atrium, Thrombosis                   |                4                             X                           |      8  4.0|
      Myocardium, Embolus                  |                                                             3            |      2  2.5|
      Myocardium, Inflammation, Focal      |                                                                          |      1  3.0|
      Myocardium, Mineralization           |    4  4                                                           1      |      4  3.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Degeneration, Focal                  |                                                    4                     |      1  4.0|
      Hyperplasia, Diffuse                 |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |    4        2     2  2                 2                    3     1      |     12  2.3|
      Necrosis, Focal                      |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |       4        2           3           1           4  3           1  1   |     18  2.0|
      Bilateral, Hyperplasia               |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  I  +  +  M  +|  42        |
      Hyperplasia                          |    4  2                                                                  |      4  3.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Hyperplasia           | 1                                         2     1                        |      6  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8|            |
                                           | 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4|      A     |
    6 MG/M3                                | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      C-Cell, Hyperplasia                  |                                  2                    3     1            |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +     +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Inflammation                         |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1     |
      Inflammation                         |                                                                          |      1  4.0|
      Lamina Propria, Fibrosis             | 1  1  1     1  2  1  1  1        2  1  2        1  1     1  2  2  2  1  1|     39  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  A  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +|  43        |
      Atrophy                              |                                                                          |      2  3.0|
      Myelofibrosis                        |                                                       3        1         |      3  2.0|
      Necrosis, Focal                      |                                                    4                     |      1  4.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Fibrosis                             |                4                                                         |      1  4.0|
      Hemorrhage, Chronic                  |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             | 3  2  2     2  2     2  1  2  3  3  2  1  2  3     2  2  2  2     2  2  1|     40  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  44        |
      Hyperplasia, Histiocytic             | 3  2  2     2  2     1  2  2  3  3  4  2           2     3  2     3  2  2|     33  2.3|
      Inflammation, Suppurative            |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |    3                                                                     |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      2  2.5|
      Fibrosis, Focal                      |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8|            |
                                           | 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4|      A     |
    6 MG/M3                                | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |    3  2                                3                 2               |      6  2.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +     I  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Galactocele                          |                                                                          |      1     |
      Hyperplasia, Cystic                  |    3                                                                     |      2  3.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrous Osteodystrophy               |    X  3                                                                  |      3  3.0|
      Hyperostosis                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Compression                          |             X                       X                                    |      7  3.7|
      Hemorrhage                           |                                     3                                    |      1  3.0|
      Inflammation, Focal                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                                     3                                    |      1  3.0|
      Inflammation, Granulomatous          | 2  1  2     1  2  1  1  1  2  2  2  2  2  1  2  1  2  1  1  1  1  1  2  2|     47  1.5|
      Inflammation, Suppurative            |                                           2                              |      1  2.0|
      Mineralization                       |    4                                                                     |      2  3.5|
      Alveolar Epithelium, Hyperplasia     | 1           1           1        1  1  1     2  1  1     1           2   |     27  1.2|
      Interstitium, Fibrosis, Focal        |       1        1  1           1  1  1  1  1  2     1  1     1     1  4  1|     24  1.5|
      Interstitium, Mineralization         |       3                                                                  |      1  3.0|
      Peribronchial, Hyperplasia,          |                                                                          |            |
          Histiocytic                      |             1           1        2                                      1|      8  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  +  +  A  +  A  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Mucosa, Inflammation, Suppurative    |                            4                                             |      3  3.3|
      Olfactory Epithelium, Metaplasia     |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 8| 8| 8| 7| 8| 6| 5| 6| 7| 6| 8| 7| 7| 7| 8| 6| 8| 8| 5| 7| 8| 6| 7| 7|            |
                             DAY ON TEST   | 6| 0| 6| 2| 3| 6| 9| 6| 5| 2| 4| 6| 5| 4| 2| 1| 7| 6| 6| 5| 9| 6| 6| 9| 8|            |
                                           | 2| 0| 3| 0| 8| 3| 7| 6| 1| 4| 7| 3| 5| 0| 9| 9| 8| 3| 3| 7| 9| 3| 8| 8| 6|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 7| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 1| 1| 3| 3| 3| 3| 4| 4| 4| 4|      A     |
    6 MG/M3                                | 1| 5| 6| 8| 9| 1| 2| 5| 6| 9| 0| 1| 2| 5| 6| 7| 8| 3| 6| 7| 8| 0| 1| 3| 4|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Hyperplasia  |                                                                          |      1  1.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                     +           +  +   |   7        |
      Inflammation                         | 1                                                     1                  |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                3                                                         |      1  3.0|
      Embolus, Multiple                    |                                                             3            |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
      Nephropathy                          | 3  4  4     3  4  2  1     1     3  2  2     1  1  3  4  1  3  2  3  3  4|     43  2.5|
      Capsule, Inflammation                |                                                                          |      1  3.0|
      Medulla, Inflammation                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  M  +  +  +  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|             
                             DAY ON TEST   | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|             
                                           | 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|             
    18 MG/M3                               | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  A|             
      Inflammation                         |                                                                          |             
      Parasite Metazoan                    |       X  X  X              X                                             |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation                         |                                                                          |             
      Parasite Metazoan                    |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  M  A|             
      Parasite Metazoan                    | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  A  +  +  +  A  +  A  A  +  +  +  A  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   3      |             
      Basophilic Focus                     | 1  4     1           3        1     1     2  1  2  2     3               |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic                 |                      2                                                   |             
      Eosinophilic Focus                   |    1        1                          1                                 |             
      Fatty Change                         |                   1     2        3  2  2        1  3     1  3  3        3|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                           2                          1   |             
      Necrosis, Focal                      |          2                                                               |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1     1  1  2  2  1     1     3  1  3  1  2  4     1     2  2         |             
      Centrilobular, Atrophy               |       3        2        2  1                          3                  |             
      Centrilobular, Degeneration          |                                  4     4                    3  4        4|             
      Centrilobular, Necrosis              |                                              3  1                        |             
      Hepatocyte, Atrophy, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Lobules, Atrophy                     | 1           2                          1        3              1  2      |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                   +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation                         |                                                                          |             
      Ulcer                                |                                                 3  4                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                         4|             
      Mineralization                       |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|             
                             DAY ON TEST   | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|             
                                           | 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|             
    18 MG/M3                               | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                   3                                                      |             
      Ulcer, Multiple                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                           +                              |             
      Aorta, Mineralization                |                                           3                              |             
      Mesenteric Artery, Mineralization    |                                           3                              |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  1  1  2  1  1  1  2     1  2  1     1  1  1  3        1              1|             
      Inflammation, Focal                  |                                                 4                        |             
      Atrium, Thrombosis                   |                                        X                                 |             
      Myocardium, Mineralization           |                   1                       4                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia, Diffuse                 |                                                                          |             
      Hyperplasia, Focal                   | 2                                               2  2        3            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          | 4                                2  3                    1  4  2  2      |             
      Bilateral, Hyperplasia               |                   2                                4                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |       2                             3                       3            |             
      Pars Distalis, Necrosis              |                         3                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      C-Cell, Hyperplasia                  |          2                                2           1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |    1                                                                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Lamina Propria, Fibrosis             |    1        2        2        1     1     1        1     2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|             
                             DAY ON TEST   | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|             
                                           | 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|             
    18 MG/M3                               | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Myelofibrosis                        |    3                                         2                           |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Axillary, Hemorrhage, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             | 2  4  2  4  3  4  4  4  2  2  3  4  2     2  2  3  2     3  4  3  2  3  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             | 2  4  2  3  4  4     3  2  4  3  1  2  1  2  2  2  2     3     2  2  2  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                                    3                     |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                   3                 3  3  2           3                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Capsule, Hemorrhage                  |                            4                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lobules, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |          X                                                               |             
      Hyperostosis                         |       X              X                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          X        X        X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|             
                             DAY ON TEST   | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|             
                                           | 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|             
    18 MG/M3                               | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      White Matter, Necrosis, Focal        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                           3                              |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X  X        X                                                      |             
      Cyst, Multiple                       |                                           X                    X         |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Diffuse, Adenomatous    |    1                                                                     |             
      Inflammation, Granulomatous          | 4  3  4  4  3  3  3  3  3  2  4  2  3  2  4  3  2  2  3  2  1  3  3  3  3|             
      Alveolar Epithelium, Hyperplasia     | 3     1  2  1  3  2  3  2  2  3  1  1  1  2  3  2  2  2  2     3  3  4  1|             
      Alveolus, Metaplasia, Squamous       |          1        1           1           1  1                           |             
      Interstitium, Fibrosis, Focal        | 3  1  1  4  1  3  2  3  2  2  3  2  1  2  2  2  3  2  2  3     4  2  1  1|             
      Interstitium, Fibrosis               |                                                                          |             
      Interstitium, Mineralization         |                                           3                              |             
      Peribronchial, Hyperplasia,          |                                                                          |             
          Histiocytic                      |             2           2     1                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Foreign Body                  |                                                                          |             
      Mucosa, Inflammation, Suppurative    | 3                 3                                                      |             
      Respiratory Epithelium, Hyperplasia  |                                           2                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Necrotizing            |                                           3                              |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
      Cataract                             |                                              3                           |             
      Retina, Degeneration                 |                                              4                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                +     +     +         |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Cyst                                 |                                                                          |             
      Infarct, Multiple                    |                                  4                                       |             
      Nephropathy                          | 1  4  1  4  3  1  2  3  2  2  3     2  2  4  3  1  4     3  1  2  1  2   |             
      Medulla, Inflammation                |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 8| 8| 7| 8| 8| 8| 8| 8| 5| 7| 8| 6| 6| 6| 8| 8| 7| 8| 7| 6| 6| 7| 5| 8| 5|             
                             DAY ON TEST   | 2| 6| 1| 2| 6| 2| 5| 6| 3| 3| 6| 1| 6| 9| 4| 4| 4| 4| 0| 7| 8| 7| 9| 3| 8|             
                                           | 8| 2| 0| 2| 2| 3| 7| 2| 6| 9| 2| 5| 1| 7| 1| 1| 6| 2| 6| 6| 4| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 6| 6| 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1|             
    18 MG/M3                               | 7| 8| 0| 2| 3| 4| 5| 6| 7| 1| 2| 3| 6| 9| 0| 1| 2| 5| 6| 7| 8| 9| 2| 5| 6|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6|            |
                             DAY ON TEST   | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7|            |
                                           | 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8|      A     |
    18 MG/M3                               | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|  43        |
      Inflammation                         |                         2              1                 3  2        1  2|      6  1.8|
      Parasite Metazoan                    |                               X  X                                       |      6     |
      Ulcer                                |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|  45        |
      Inflammation                         |                         2                                   2            |      2  2.0|
      Parasite Metazoan                    |          X                                                        X      |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  A  +  +  +|  41        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Basophilic Focus                     |    1  1  1  1  3  2  2        2        1                          1      |     21  1.7|
      Clear Cell Focus                     |                         1                                                |      1  1.0|
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                         2                                                |      4  1.3|
      Fatty Change                         |                      1           3                       2               |     14  2.1|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                              4                           |      1  4.0|
      Inflammation, Focal, Granulomatous   |    1                                   2                                 |      4  1.5|
      Necrosis, Focal                      |                                                 3                        |      2  2.5|
      Thrombosis                           |                                                             X            |      1     |
      Bile Duct, Hyperplasia               |    2  1     2  2  1  1  3  3     1     1        1  1  1  2  2  1  3  3  4|     36  1.8|
      Centrilobular, Atrophy               |             2                                                            |      6  2.2|
      Centrilobular, Degeneration          |                         2                    1              4        4  3|     10  3.3|
      Centrilobular, Necrosis              |                                                                          |      2  2.0|
      Hepatocyte, Atrophy, Focal           |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lobules, Atrophy                     |    3                                                  1  1               |      9  1.7|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       |          3                                                               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6|            |
                             DAY ON TEST   | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7|            |
                                           | 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8|      A     |
    18 MG/M3                               | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                      3                             3                     |      2  3.0|
      Ulcer                                |                         3                                                |      3  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  4.0|
      Mineralization                       |                                        3                                 |      2  2.5|
      Ulcer                                |             3                                   3                        |      3  3.0|
      Ulcer, Multiple                      |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Aorta, Mineralization                |                                                                          |      1  3.0|
      Mesenteric Artery, Mineralization    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  2  1  1  1     1  1  1  2  1  2  1     2  2           2     1  1|     36  1.4|
      Inflammation, Focal                  |                                                                          |      1  4.0|
      Atrium, Thrombosis                   |                         X                    X              X        X   |      5     |
      Myocardium, Mineralization           |                                        2                                 |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Diffuse                 |                            3                                             |      1  3.0|
      Hyperplasia, Focal                   |          2  2        3        3        2     3  4        2           1   |     13  2.4|
      Necrosis                             |                                                             3        2   |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                         3        3           2  4        1  2        2   |     14  2.5|
      Bilateral, Hyperplasia               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                        3                                 |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |       3                                                                  |      1  3.0|
      Pars Distalis, Hyperplasia           |                                           2                              |      4  2.5|
      Pars Distalis, Necrosis              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |                                        1                                 |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6|            |
                             DAY ON TEST   | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7|            |
                                           | 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8|      A     |
    18 MG/M3                               | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
      Hyperplasia                          |                                  4                                       |      1  4.0|
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                       X                  |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |             X                                                            |      1     |
      Lamina Propria, Fibrosis             |    1  1  2     2  1  1  1  2           1        1                 2      |     19  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                      3   |      1  3.0|
      Hyperplasia, Histiocytic             |                4                                                         |      1  4.0|
      Myelofibrosis                        |                                                             3            |      3  2.7|
      Myeloid Cell, Hyperplasia            |       3     3     3                                                      |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Axillary, Hemorrhage, Chronic        |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Histiocytic             | 3  3  3  3  3  4  3  3  3           3  3  3  3  4  3  1  3  3  3  3  2  2|     45  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                                       4                  |      1  4.0|
      Hyperplasia, Plasma Cell             |                   3                                                      |      1  3.0|
      Inflammation, Chronic Active         |                                              3                           |      1  3.0|
      Inflammation, Suppurative            |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  47        |
      Hyperplasia, Histiocytic             | 2        2  2     2  3        2  3  3  4  3  2  4  2  2  3  3  3     2   |     40  2.5|
      Hyperplasia, Lymphoid                |                                                                         3|      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                                                          3               |      2  3.0|
      Inflammation, Granulomatous          |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3                    3                                                   |      2  3.0|
      Fibrosis, Focal                      |                                                                   3      |      1  3.0|
      Hematopoietic Cell Proliferation     |             3  3                                                         |      7  2.9|
      Hyperplasia, Lymphoid                |                                                             3            |      1  3.0|
      Capsule, Hemorrhage                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6|            |
                             DAY ON TEST   | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7|            |
                                           | 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8|      A     |
    18 MG/M3                               | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Lobules, Hyperplasia                 |                                                                   4      |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                            X           X        X                        |      4     |
      Hyperostosis                         |                                                    X                     |      3     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |          X     X           X  X  X                                X      |      9     |
      Hemorrhage                           |    3                                                                     |      1  3.0|
      Hydrocephalus                        |          3                                                               |      1  3.0|
      White Matter, Necrosis, Focal        |       3                                                              4   |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  I  +  +  +|  48        |
      Inflammation, Necrotizing            |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |          X                                         X                     |      5     |
      Cyst, Multiple                       |                                                                          |      2     |
      Hemorrhage                           |    3                                                                     |      1  3.0|
      Hyperplasia, Diffuse, Adenomatous    |                                                                   2      |      2  1.5|
      Inflammation, Granulomatous          | 2  2  4  3  2  3  3  3  2  2  3  3  2  4  4  3  4  3  2  2  2  3  2  3  3|     50  2.8|
      Alveolar Epithelium, Hyperplasia     | 2  2  3  2  1  2  2  2  1  2  2  3  1  3  3  3  2  3  2     2  1  3  3  2|     47  2.1|
      Alveolus, Metaplasia, Squamous       |       2        1                          1                              |      8  1.1|
      Interstitium, Fibrosis, Focal        | 3  3     3  1  2  1  1  2     1  2  4  1  2  3  1  3        2     2  3  1|     45  2.1|
      Interstitium, Fibrosis               |       3                                                                  |      1  3.0|
      Interstitium, Mineralization         |                                                                          |      1  3.0|
      Peribronchial, Hyperplasia,          |                                                                          |            |
          Histiocytic                      |             1  2  1           1     1                             1      |      9  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lumen, Foreign Body                  |          1                                                               |      1  1.0|
      Mucosa, Inflammation, Suppurative    |          2  4                                               2            |      5  2.8|
      Respiratory Epithelium, Hyperplasia  |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 8| 8| 7| 7| 8| 7| 6| 8| 8| 6| 7| 7| 8| 8| 7| 8| 8| 5| 6| 7| 6| 8| 7| 6|            |
                             DAY ON TEST   | 4| 5| 6| 9| 1| 6| 4| 9| 0| 6| 7| 2| 8| 4| 6| 4| 5| 2| 5| 6| 1| 3| 6| 8| 7|            |
                                           | 6| 4| 2| 6| 7| 3| 7| 3| 3| 3| 8| 4| 4| 8| 3| 0| 0| 9| 8| 0| 6| 3| 3| 6| 5|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5| 6| 6| 7| 8| 8| 8| 8| 8| 8| 8|      A     |
    18 MG/M3                               | 0| 1| 2| 3| 6| 8| 9| 0| 3| 4| 5| 6| 7| 8| 9| 3| 4| 7| 0| 1| 2| 5| 6| 7| 8|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Necrotizing            |                                                                          |      1  3.0|
      Inflammation, Suppurative            |             2                                               2            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                                         |   2        |
      Cataract                             |                4                                                         |      2  3.5|
      Retina, Degeneration                 |                4                                                         |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +        +  +     +  +  +  +     +  +                 +     +|  15        |
      Inflammation                         |             2                          2                          1      |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                        +                                 |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                           3                              |      1  3.0|
      Infarct, Multiple                    |                                                                          |      1  4.0|
      Nephropathy                          | 1  2  3  4     3     4  1  2  1  1  2  4  3     4  3  1  1  2     2  1   |     42  2.3|
      Medulla, Inflammation                |                                                    4                     |      1  4.0|
      Renal Tubule, Necrosis               |             4     4                                                      |      2  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation                         |                                                                         3|      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1|        |            |
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9|        |            |
                                           | 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|        |      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3|        |      A     |
    CONTROL                                | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  M  +  +  +     +  +  M  +  +        +           +     +         |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Parasite Metazoan                    |                               2                                2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Parasite Metazoan                    |                   X                                      X               |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Basophilic Focus                     |                1                             1                           |      2  1.0|
      Eosinophilic Focus                   | 2        1                                                               |      2  1.5|
      Fatty Change                         |                         2                                                |      1  2.0|
      Hyperplasia                          |                         2                                                |      1  2.0|
      Inflammation, Chronic                |                                     1                                    |      1  1.0|
      Bile Duct, Hyperplasia               | 2        1     1  1        1                 1           1               |      7  1.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Lobules, Atrophy                     | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Cardiomyopathy                       | 1  2     1     2        2                                1               |      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +     +  +  +  +  +        +           +     +         |  14        |
      Congestion                           |                         4                                                |      1  4.0|
      Degeneration, Cystic                 |                         3                                                |      1  3.0|
      Vacuolization Cytoplasmic            |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M     +  +  +  +  +        +           +     +         |  14        |
      Hyperplasia                          |                3        2                                1               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +     M  +  +  +  +        +           +     +         |  14        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1|        |            |
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9|        |            |
                                           | 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|        |      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3|        |      A     |
    CONTROL                                | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +     +  +  M  +  M        +           +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  M  +  +  +  +  +     +  +  +  +  M        +           +     +         |  13        |
      C-Cell, Hyperplasia                  |          1     2        1  1                                             |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Cyst                                 |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Hyperplasia, Histiocytic             |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  M  +  +  M     M  +  +  +  +        +           M     +         |  10        |
      Hyperplasia, Lymphoid                | 2                                                                        |      1  2.0|
      Pigmentation, Hemosiderin            |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  M  +  +        M     +  +  +        +           M     +         |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +     M  M  +  M  +        +           M     +         |  11        |
      Congestion                           |       2                       1                                          |      2  1.5|
      Pigmentation, Hemosiderin            |                2  1                                                      |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +     +  +  +  +  +        +                 +         |  14        |
      Hyperplasia, Histiocytic             |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +     M  +  +  +  +        +           +     +         |  14        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Hyperplasia, Cystic                  |    2                    3                                                |      2  2.5|
      Lobules, Hyperplasia                 | 1                                                        2               |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Femur, Hyperplasia                   |                                                                3         |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 8| 7| 3| 7| 1| 7| 5| 4| 7| 5| 3| 1| 3| 7| 6| 5| 6| 7| 7| 7| 1| 1|        |            |
                             DAY ON TEST   | 6| 3| 3| 3| 9| 3| 5| 5| 3| 5| 3| 9| 3| 2| 7| 5| 2| 1| 1| 3| 8| 9|        |            |
                                           | 2| 9| 3| 9| 2| 9| 6| 0| 9| 6| 3| 3| 3| 8| 3| 6| 2| 6| 8| 9| 0| 4|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|        |      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 3| 3| 4| 5| 5| 6| 7| 7| 7| 9| 0| 0| 0| 2| 2| 2| 3|        |      A     |
    CONTROL                                | 4| 7| 9| 0| 5| 3| 4| 9| 3| 4| 0| 5| 8| 9| 8| 1| 4| 5| 1| 3| 6| 1|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Compression                          | X                                                                        |      1     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
      Inflammation, Granulomatous          |          1                                                               |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |          1        1                                                      |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
      Nephropathy                          | 3  2     2     2  1     2  1                 1           2               |      9  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +     +  +  +  +  +        +           +     +         |  15        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7|        |            |
                             DAY ON TEST   | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3|        |            |
                                           | 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|        |      T     |
                               ANIMAL ID   | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4|        |      A     |
    6 MG/M3                                | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +  +  +  +  +  +        +  M     +  +  +  +  +  +  +         |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Parasite Metazoan                    |          2     2           1        1           X           1            |      6  1.4|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Basophilic Focus                     |    1              1                             1        1               |      4  1.0|
      Fatty Change                         |                         3                                                |      1  3.0|
      Inflammation, Chronic                |                                                                2         |      1  2.0|
      Bile Duct, Hyperplasia               |       1        1  1     1  1           1              1        1         |      8  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Inflammation                         |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +            |  17        |
      Hyperplasia, Squamous                |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +            |  17        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Cardiomyopathy                       |       2           2  2  3                    1        1  2     2         |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +     +  +        +  +        +  +  +  +  +  +         |  16        |
      Congestion                           |          2                                                               |      1  2.0|
      Degeneration, Fatty                  |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Hyperplasia                          |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  I         |  17        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +  +  +  +  +  M        +  +     M  +  +  +  +  M  +         |  15        |
      Cyst                                 |       X                                                                  |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7|        |            |
                             DAY ON TEST   | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3|        |            |
                                           | 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|        |      T     |
                               ANIMAL ID   | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4|        |      A     |
    6 MG/M3                                | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                    X                     |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      C-Cell, Hyperplasia                  |       1                                1                                 |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  M  I         |  16        |
      Fibrosis                             |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Hyperplasia, Cystic                  |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Hyperplasia, Histiocytic             |                                     2                          2         |      2  2.0|
      Femoral, Hyperplasia, Histiocytic    |             2                                                            |      1  2.0|
      Myeloid Cell, Hyperplasia            |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Renal, Hyperplasia, Histiocytic      |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Hyperplasia, Histiocytic             |    2  2  2  2  2  3  2  2  2        2  2     2  2  2  2  2  2  2         |     18  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +  +  +  M  +  +  +  +        M  +     M  +  +  +  M  +  +         |  14        |
      Hyperplasia, Lymphoid                |                                                    3           3         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +  +  +  +  +  +  +  +  +        M  +     +  +  +  +  +  +  +         |  17        |
      Congestion                           |          2                                                               |      1  2.0|
      Hyperplasia, Histiocytic             |       1        2  2  2  2  2           1     2  2  2  2  2  2  2         |     14  1.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Edema                                |          3                                                               |      1  3.0|
      Hyperplasia, Histiocytic             |                            3                                             |      1  3.0|
      Hyperplasia, Lymphoid                |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Hematopoietic Cell Proliferation     |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    M  +  +  +  +  +  +  +  +        +  M     +  +  +  +  M  +  +         |  15        |
      Cyst                                 |                                              X                           |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 3| 1| 3| 7| 7| 7| 3| 5| 7| 1| 5| 7| 7| 7| 5| 5| 7| 1| 7|        |            |
                             DAY ON TEST   | 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 1| 3| 9| 5| 1| 3| 3| 5| 5| 3| 9| 3|        |            |
                                           | 5| 9| 9| 3| 2| 3| 9| 9| 9| 3| 0| 4| 3| 6| 6| 9| 9| 6| 6| 9| 4| 9|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1|        |      T     |
                               ANIMAL ID   | 1| 1| 1| 2| 4| 4| 4| 6| 6| 7| 8| 9| 9| 9| 1| 1| 1| 2| 3| 3| 3| 4|        |      A     |
    6 MG/M3                                | 3| 5| 9| 2| 1| 2| 6| 1| 5| 2| 7| 0| 3| 4| 3| 4| 9| 0| 4| 5| 9| 2|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Inflammation, Granulomatous          |    1  1  1  1  2  1  2  1  2        1  2     2  1  2  1  2  2  2         |     18  1.5|
      Alveolar Epithelium, Hyperplasia     |    1  1  1     1  1  2  2  1           1     2  1  1  1  1  1  2         |     16  1.3|
      Interstitium, Fibrosis, Focal        |    1  1        1  1  2  1  1           2     2  1  1  1        2         |     13  1.3|
      Peribronchial, Hyperplasia,          |                                                                          |            |
          Histiocytic                      |                1                             1  1     1     1            |      5  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                                                         |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
      Nephropathy                          |    1  2           2  2  3              1     2  3  2  1  3     3         |     12  2.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +        +  +     +  +  +  +  +  +  +         |  18        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1|        |            |
                             DAY ON TEST   | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9|        |            |
                                           | 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|        |      T     |
                               ANIMAL ID   | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8|        |      A     |
    18 MG/M3                               | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     M        M  +  +     +     M  +  +           +     M     +         |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Parasite Metazoan                    | 3                 1                 1              2                     |      4  1.8|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Parasite Metazoan                    |                                  X                                       |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Basophilic Focus                     |                            2                             2               |      2  2.0|
      Fibrosis, Focal                      |                                        2                                 |      1  2.0|
      Inflammation, Chronic                |                                        3                                 |      1  3.0|
      Bile Duct, Hyperplasia               |       1                    1           2                 1               |      4  1.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Cardiomyopathy                       |                            2           2                 3               |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +        +  M  +     +     +  +  +           +     +     +         |  11        |
      Hyperplasia                          |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     +        +  +  M     +     M  M  +           +     +     M         |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Pars Distalis, Hyperplasia           |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +        +  +  +     +     I  +  +           +     +     +         |  11        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1|        |            |
                             DAY ON TEST   | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9|        |            |
                                           | 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|        |      T     |
                               ANIMAL ID   | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8|        |      A     |
    18 MG/M3                               | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Hyperplasia, Histiocytic             | 2                                                              2         |      2  2.0|
      Myeloid Cell, Hyperplasia            |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +        +  +        +     +  +  M           +     +     +         |   9        |
      Hyperplasia, Histiocytic             |                3  3        3     2  3              3     4     2         |      8  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +        +  +  +     +     +  M  +           +     +     +         |  11        |
      Congestion                           | 3                                                                        |      1  3.0|
      Hyperplasia, Lymphoid                |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Congestion                           |       2                                                                  |      1  2.0|
      Hyperplasia, Histiocytic             | 2              3  3  2     3     2  3              3     4               |      9  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Inflammation, Granulomatous          | 3     2        2  3  3     1     2  3  2           2     2     3         |     12  2.3|
      Alveolar Epithelium, Hyperplasia     | 1     1        1  2        2     2  2  2           3     3               |     10  1.9|
      Interstitium, Fibrosis, Focal        |       2        2  1        2     1  1  4           1     3               |      9  1.9|
      Peribronchial, Hyperplasia,          |                                                                          |            |
          Histiocytic                      | 1     1        1     1              2              1                     |      6  1.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 6| 5| 6| 5| 5| 3| 1| 6| 7| 7| 5| 3| 7| 3| 6| 6| 3| 6| 7| 5| 1|        |            |
                             DAY ON TEST   | 9| 5| 5| 9| 9| 5| 3| 9| 2| 3| 2| 5| 3| 3| 7| 7| 4| 3| 2| 3| 5| 9|        |            |
                                           | 2| 0| 6| 8| 4| 6| 3| 3| 1| 9| 6| 6| 3| 9| 6| 7| 8| 3| 1| 9| 8| 4|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|        |      T     |
                               ANIMAL ID   | 5| 6| 6| 8| 8| 8| 8| 1| 1| 1| 1| 2| 3| 3| 3| 6| 6| 6| 7| 7| 8| 8|        |      A     |
    18 MG/M3                               | 9| 1| 8| 4| 5| 7| 8| 0| 1| 3| 4| 9| 4| 5| 7| 0| 1| 2| 8| 9| 3| 4|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                      +                                                   |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
      Nephropathy                          |       2        1           2     1     2                 2               |      6  1.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +        +  +  +     +     +  +  +           +     +     +         |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|             
                             DAY ON TEST   | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|             
                                           | 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         2  3  2        1     2                 3     2   |             
      Parasite Metazoan                    |    X                                                                     |             
      Ulcer                                |                                     4                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation                         |                                                                          |             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
      Inflammation                         |                   2     2                                               1|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis, Focal                      |                                                                         2|             
      Ulcer                                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                            2                                             |             
      Atrophy                              |                                                                         2|             
      Basophilic Focus                     |       2                 1  1  2        1     2  3              1  1  1   |             
      Clear Cell Focus                     |                                                                   1      |             
      Degeneration, Cystic                 |                            3        3        2                          2|             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |             3                    3  2  2              3  3  3            |             
      Fibrosis                             | 2                                                                        |             
      Inflammation, Focal, Granulomatous   |          1                                                               |             
      Necrosis, Focal                      |                                                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 4     1  1  4     2     2  4  3  3  4  3     3  1        3  4  3  1  1  2|             
      Centrilobular, Atrophy               |                               2        2     2        2        2         |             
      Centrilobular, Degeneration          | 3           4              4                             4  4            |             
      Centrilobular, Necrosis              |                   4                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                                                                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lobules, Atrophy                     |                2        1  1  1     1                          1  3     1|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             1                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                  2                                       |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|             
                             DAY ON TEST   | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|             
                                           | 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                        4                 1  2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2                                                        3   |             
      Ulcer                                |             2     4                                      1               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +           +   |             
      Aorta, Mineralization                |                                                                      3   |             
      Mesenteric Artery, Mineralization    |                                                                      3   |             
      Mesenteric Artery, Thrombosis        |                                                                      X   |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1     2     2  2     1  2  3  1  3  3  1  2  1  2  2  1  2  2  2     3|             
      Atrium, Thrombosis                   |                            X  X                                      X  X|             
      Epicardium, Hyperplasia              |                      3                                                   |             
      Myocardium, Mineralization           |                                                                      4   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |             3        2     3     3                       3  2  2         |             
      Degeneration, Focal                  |                                                                          |             
      Degeneration                         |                                                                      4   |             
      Hyperplasia, Focal                   |                   2                                            2         |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1        1                 3        1        4     1  2     2  2      |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                   3                 3   |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |          3                       3     1  2     1                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1                                   1           1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4        4        4                                                      |             
      Inflammation                         | 4  2     3        3                                         2        2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|             
                             DAY ON TEST   | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|             
                                           | 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               2                                          |             
      Inflammation                         |             2  3  2     3        2        1  2     1        3  2        2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               2                                          |             
      Inflammation                         |                                                                         1|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 4                          4        3  3                             3   |             
      Interstitial Cell, Hyperplasia       |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pancreatic, Atrophy                  |                                        3                                 |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy                              |                   3                    3                                 |             
      Hemorrhage, Acute                    |                                                                      3   |             
      Hemorrhage, Chronic                  |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        3                                 |             
      Hemorrhage, Acute                    |                                                                      3   |             
      Hemorrhage, Chronic                  |                      3                                                   |             
      Pigmentation, Hemosiderin            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        3                                 |             
      Hemorrhage, Acute                    |                                                                      3   |             
      Hyperplasia, Lymphoid                |                                     3                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        3                                 |             
      Congestion, Chronic                  |                                                                         4|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Infarct                              |                            3                                   3        3|             
      Inflammation, Focal, Granulomatous   |                1                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Galactocele                          | X                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tail, Necrosis                       | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|             
                             DAY ON TEST   | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|             
                                           | 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                      X   |             
      Coccygeal, Necrosis                  | 4                                                                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Necrosis, Focal                      |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3     1                                      1                       3   |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Crystals, Focal                      |                                                          1               |             
      Hemorrhage, Chronic                  |                                                    3                     |             
      Infarct                              |                               2                                          |             
      Inflammation, Granulomatous          |                                                    1                     |             
      Alveolar Epithelium, Hyperplasia     |    3                       2           2                                 |             
      Alveolus, Hemorrhage, Focal          |                                                                      2   |             
      Artery, Thrombosis                   |                                                                          |             
      Interstitium, Fibrosis, Focal        |                                                                          |             
      Interstitium, Mineralization         |                                                                      3   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 1                                                                        |             
      Lumen, Foreign Body                  |                                                                1         |             
      Mucosa, Inflammation, Suppurative    |             2                                                  3     2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Cataract                             |                                                                          |             
      Cornea, Necrosis                     |             4                                                            |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X                                                  X   |             
      Nephropathy                          | 2  3  1     2  4  3     1  3  2  2  3  3  2  3  3  4  1  1  3  2  4  4  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 8| 5| 5| 7| 8| 7| 3| 7| 7| 6| 5| 7| 7| 8| 7| 7| 7| 6| 5| 6| 6| 8| 6| 7|             
                             DAY ON TEST   | 4| 0| 8| 9| 2| 0| 4| 6| 0| 0| 9| 9| 4| 8| 0| 8| 9| 9| 3| 5| 3| 8| 0| 7| 6|             
                                           | 6| 0| 6| 0| 4| 0| 1| 0| 9| 0| 8| 3| 7| 7| 0| 2| 9| 5| 1| 1| 5| 2| 0| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 3| 4| 5| 6| 7| 8| 0| 3| 6| 7| 8| 9| 1| 2| 3| 4| 7| 9| 0| 2| 3| 4| 5| 7|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6|            |
                             DAY ON TEST   | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2|            |
                                           | 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    CONTROL                                | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  A  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  A  +  +  A  +  A  +  M  +  +  +  A  A  +  +|  42        |
      Inflammation                         |                                  2                    2                  |      9  2.1|
      Parasite Metazoan                    |    X                 X                                                   |      3     |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  A  +  +|  43        |
      Hyperplasia, Lymphoid                |       3                                                                  |      1  3.0|
      Inflammation                         | 1                                                                        |      1  1.0|
      Parasite Metazoan                    |                         X                                                |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +     M  +  +  +  +  +  +  M  A  +  A  +  +  +  +  +  A  A  +  M|  38        |
      Inflammation                         | 1     4  4                                                               |      6  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Mineralization                       |                                              2                           |      1  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  A  +  +     +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  A  A  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  +  +     +  +  +  +  +  A  +  +  A  +  A  +  +  +  +  A  A  A  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Atrophy                              |                                                                          |      1  2.0|
      Basophilic Focus                     |                   1  1  2     3                 2                 2  1  1|     18  1.6|
      Clear Cell Focus                     |                      1                             1                     |      3  1.0|
      Degeneration, Cystic                 |          2     1                             1  2     3                  |      9  2.1|
      Eosinophilic Focus                   |                                                    1        2            |      2  1.5|
      Fatty Change                         |       2                    2  2     3           2  1  2  2              2|     16  2.3|
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Focal, Granulomatous   |                                        2                          2      |      3  1.7|
      Necrosis, Focal                      |          2                    2                             1            |      3  1.7|
      Thrombosis                           |                                                             X            |      1     |
      Bile Duct, Hyperplasia               | 2     2  4     2     1  2  1  3  3        4  3  2  3  4  2  4  1  2  1  2|     39  2.5|
      Centrilobular, Atrophy               |       1                                                  1        3     2|      9  1.9|
      Centrilobular, Degeneration          |          4                                3        4                     |      8  3.8|
      Centrilobular, Necrosis              |                                  3  3  4              4                  |      5  3.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Lobules, Atrophy                     |                      2                          1                    1   |     11  1.4|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6|            |
                             DAY ON TEST   | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2|            |
                                           | 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    CONTROL                                | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                                          |      1  2.0|
      Mineralization                       |                                              4                           |      1  4.0|
      Ulcer                                |       3                             4                                    |      5  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mineralization                       |                               3        1     4  2                        |      6  2.5|
      Ulcer                                |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                               +              +                           |   4        |
      Aorta, Mineralization                |                               2              4                           |      3  3.0|
      Mesenteric Artery, Mineralization    |                               2              3                           |      3  2.7|
      Mesenteric Artery, Thrombosis        |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cardiomyopathy                       | 2     2        3     2  2  2  3  1  2  3  2  3  3  2  2  3  2  1  2  2  2|     42  2.0|
      Atrium, Thrombosis                   |                               X        X  X     X     X                  |      9     |
      Epicardium, Hyperplasia              |                                                                          |      1  3.0|
      Myocardium, Mineralization           |                                              4                           |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  |                                                 2                        |      8  2.5|
      Degeneration, Focal                  |                                                       3                  |      1  3.0|
      Degeneration                         |                                                                          |      1  4.0|
      Hyperplasia, Focal                   | 2                 2                 2        2     3     3     1  3     1|     11  2.0|
      Necrosis, Focal                      |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       3        4           1     3  3              4        4  4  2     4|     19  2.6|
      Bilateral, Hyperplasia               |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +     M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                      3        3              3                           |      6  2.8|
      Bilateral, Hyperplasia               |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|  47        |
      Pars Distalis, Hyperplasia           | 2     2                                         2                        |      8  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6|            |
                             DAY ON TEST   | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2|            |
                                           | 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    CONTROL                                | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  | 1                                                     3                  |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                          |      3  4.0|
      Inflammation                         |          1                                                               |      7  2.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  2.0|
      Inflammation                         | 3  4  3  2                 3  2  2     1           1     2     2         |     22  2.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                4              4     4     3  3  3  3     3     3         |     14  3.4|
      Interstitial Cell, Hyperplasia       |                1                                                         |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  48        |
      Myeloid Cell, Hyperplasia            |                                                                         3|      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pancreatic, Atrophy                  |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +     +  +  +  M  +  +  +  I  M  +  +  M  +  +  M  +  +  +  M  +|  41        |
      Atrophy                              |                                                                          |      2  3.0|
      Hemorrhage, Acute                    |                                                                          |      1  3.0|
      Hemorrhage, Chronic                  |                                                                2  2     2|      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  3.0|
      Hemorrhage, Acute                    |                                                                          |      1  3.0|
      Hemorrhage, Chronic                  |                                                       3  3     2  3     2|      6  2.7|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Hemorrhage, Acute                    |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6|            |
                             DAY ON TEST   | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2|            |
                                           | 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    CONTROL                                | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Congestion, Chronic                  |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                         3|      1  3.0|
      Infarct                              |                                                                          |      3  3.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |       X                                                                  |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  45        |
      Galactocele                          |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Tail, Necrosis                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Fibrous Osteodystrophy               |                                              X  X                        |      3     |
      Coccygeal, Necrosis                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Compression                          |                X           X        X                    X     X         |      5     |
      Necrosis, Focal                      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            | 2                                            1                           |      6  1.8|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           | 4                                                                        |      1  4.0|
      Crystals, Focal                      |                                                                          |      1  1.0|
      Hemorrhage, Chronic                  |                                                          2               |      2  2.5|
      Infarct                              |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                    1                     |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                    1     2               |      5  2.0|
      Alveolus, Hemorrhage, Focal          |                                                                          |      1  2.0|
      Artery, Thrombosis                   |                                                                   X      |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 3| 7| 6| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 8| 6|            |
                             DAY ON TEST   | 8| 3| 4| 5| 9| 4| 2| 9| 9| 0| 9| 2| 8| 8| 0| 6| 9| 6| 5| 6| 3| 8| 5| 0| 2|            |
                                           | 2| 4| 5| 0| 9| 0| 9| 9| 9| 0| 9| 2| 5| 4| 4| 4| 0| 1| 9| 8| 9| 6| 6| 0| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4|      T     |
                               ANIMAL ID   | 4| 6| 6| 6| 6| 6| 6| 6| 7| 8| 8| 8| 8| 8| 9| 9| 9| 1| 1| 1| 1| 1| 1| 1| 2|      A     |
    CONTROL                                | 8| 1| 2| 3| 5| 7| 8| 9| 1| 5| 6| 7| 8| 9| 0| 1| 6| 0| 1| 3| 4| 5| 8| 9| 0|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Interstitium, Fibrosis, Focal        |                               1                                          |      1  1.0|
      Interstitium, Mineralization         |                                              4                           |      2  3.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                             1            |      2  1.0|
      Lumen, Foreign Body                  |                                                                          |      1  1.0|
      Mucosa, Inflammation, Suppurative    |       1                                                                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            | 2                                            1                           |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                          +      |   3        |
      Cataract                             |                                        4                                 |      1  4.0|
      Cornea, Necrosis                     |                                                                          |      1  4.0|
      Lens, Cataract                       |                                                                   4      |      1  4.0|
      Retina, Degeneration                 |                                        4                          4      |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                                                 X                        |      3     |
      Nephropathy                          | 2     3  3     2     4  3  3  4  1  3  4  2  4  4  3  2  3  2  4  1  2  3|     45  2.7|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                 2                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|             
                                           | 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/M3                                | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  A  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  A|             
      Hemorrhage                           |                            4                                             |             
      Inflammation                         |                         1                                                |             
      Parasite Metazoan                    | X           X                       X           X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  A  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  A  A|             
      Inflammation                         |                         1                                                |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  A|             
      Ulcer                                |                         3                                                |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  A  +  A  +  +  +  A  A  +  +  +  +  +  +  +  A  A  A|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphatic, Ectasia                   |       3                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  A  +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | 2        2     1              1     1           1     2     2     2      |             
      Clear Cell Focus                     |                2                 2  1           2           1            |             
      Congestion                           |                      3                                                   |             
      Degeneration, Cystic                 | 2     1        2  1              2        1  2           3  2           2|             
      Eosinophilic Focus                   |                   1                    1  1                    1         |             
      Fatty Change                         |       3                 3                          2  2                  |             
      Hematocyst                           |                                                                          |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Bile Duct, Hyperplasia               | 2  4  1  2     1  2  1  3  3  1     1  4  2  2  2  3  2  2  1  3  2  1  1|             
      Centrilobular, Atrophy               |                                        3  4                              |             
      Centrilobular, Degeneration          |                                                    4           2     2  2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Lobules, Atrophy                     |    1  1                 2                          3     2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Mineralization                       |                                                       3                  |             
      Ulcer                                |                                                    4                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Mineralization                       |                            4                          3                  |             
      Ulcer                                |                         3                                      3         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                            +                          +                  |             
      Aorta, Mineralization                |                            3                          3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|             
                                           | 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/M3                                | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Mesenteric Artery, Mineralization    |                            3                          3                  |             
      Mesenteric Artery, Thrombosis        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1  2     1  1     2  2  2  2  2  3  2  1  2  3  2  2  2  2  2  1  1|             
      Atrium, Thrombosis                   |    X                       X                       X     X               |             
      Myocardium, Inflammation             |                                                                          |             
      Myocardium, Mineralization           |          3                                            2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                     2                                    |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2           2                                               2        4|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +|             
      Hyperplasia                          |                2     2                 2              1                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Cyst                                 |                                        3                                 |             
      Pars Distalis, Hyperplasia           | 3              2                          1     1  1           1         |             
      Pars Nervosa, Hyperplasia            |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A|             
      C-Cell, Hyperplasia                  |                   1     1                             1     2  2         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Spermatocele                         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                       1                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation                         |       3                    2  3     2  3           3  2  2               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3                       3              3  3        3      |             
      Hyperplasia, Lymphoid                |                                  1           2                           |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|             
                                           | 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/M3                                | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                  2                                       |             
      Myelofibrosis                        |                            2                                             |             
      Myeloid Cell, Hyperplasia            |                               3                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Chronic                  |                      2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                             |             
      Hyperplasia, Histiocytic             | 2  3  2  3     2  3     2  2  2  3  2  3  3  2  4     1  2  2  2  3  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                         4|             
      Hyperplasia, Lymphoid                |                                                 3                        |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            3                                            4|             
      Hyperplasia, Histiocytic             | 2  3  1  2  2  2  3     2     1  3  2     3  2  2     1  1  3  2  3  2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                         4|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      | 3                                            3     3        4            |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Histiocytic             |                               3                                          |             
      Hyperplasia, Lymphoid                |                3                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +  +  +  +  +  M|             
      Atrophy                              |                   4  3                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                   X                                   X                  |             
      Pelvis, Fracture                     |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                       X  X               |             
      Hemorrhage                           |                                                                          |             
      Necrosis, Focal                      |                         4              3                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 5| 7| 1| 8| 6| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 5|             
                             DAY ON TEST   | 9| 7| 7| 8| 8| 0| 1| 2| 4| 8| 2| 9| 5| 5| 9| 9| 9| 9| 8| 8| 9| 9| 4| 6| 4|             
                                           | 9| 7| 3| 7| 6| 0| 1| 2| 6| 3| 7| 9| 7| 9| 1| 9| 9| 3| 1| 0| 9| 0| 0| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 1| 1| 2| 2| 2| 3| 3| 3| 3| 3| 3| 4| 5| 5| 5| 5| 5| 5| 5|             
    6 MG/M3                                | 1| 3| 4| 5| 6| 8| 1| 2| 6| 8| 9| 0| 1| 2| 4| 5| 6| 9| 0| 1| 2| 3| 6| 7| 9|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Granulomatous          | 1  2  2  2  1  1  1  1  3  3  1  1  2  2  2  1  2  2  1  3  1  1  2  2  2|             
      Inflammation, Suppurative            |                      3                                                   |             
      Mineralization                       |                            3                                             |             
      Alveolar Epithelium, Hyperplasia     | 1        1     1  2           1  1  1        2  1     2  1  1  1  2      |             
      Interstitium, Fibrosis, Focal        |    1     1     1                             1     1  1     1            |             
      Interstitium, Mineralization         |                                                       3                  |             
      Peribronchial, Hyperplasia,          |                                                                          |             
          Histiocytic                      | 1  1           1              1  1                                1      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Inflammation, Suppurative    |             3        4                                2                  |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |          2                                                               |             
      Respiratory Epithelium, Hyperplasia  |             3                                   3                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                                            |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hydronephrosis                       |                   3                                                      |             
      Nephropathy                          | 3  2  1  4     3  2  1  2  4  2  3  1  3  3  4  3  1  4  4  3  2  2  1   |             
      Medulla, Inflammation                |                                                                          |             
      Renal Tubule, Necrosis               |                                                                3         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7|            |
                             DAY ON TEST   | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4|            |
                                           | 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    6 MG/M3                                | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  A  +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  A  +  +  +|  38        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation                         |                                                                         3|      2  2.0|
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  43        |
      Parasite Metazoan                    |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
      Inflammation                         |                                                                          |      1  1.0|
      Parasite Metazoan                    |                      X        X                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  44        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  A  +  +  +  A  +  +  A  +  A  +  +  +  A  +  +  A  +  +  A|  34        |
      Hyperplasia, Lymphoid                |                                        3                                 |      1  3.0|
      Lymphatic, Ectasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  +|  38        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |    1     1                    1     2     1        2     1        2  1   |     18  1.4|
      Clear Cell Focus                     |       1                       2                                          |      7  1.6|
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Cystic                 |             2     1           1                    2     1        1  2   |     17  1.6|
      Eosinophilic Focus                   |          2  3        3                                                   |      7  1.7|
      Fatty Change                         | 3  1           2  2        3           3  1     2  2  2                  |     14  2.2|
      Hematocyst                           |                                           X                              |      1     |
      Inflammation, Focal, Granulomatous   |                               1                                          |      1  1.0|
      Bile Duct, Hyperplasia               | 4  1  1  4     3  1  3  2  2  1  1  1  3     1  2  2  1  2  3  2  2  1  2|     46  2.0|
      Centrilobular, Atrophy               |                2                                               3         |      4  3.0|
      Centrilobular, Degeneration          | 4        2           3  2              4        3     3     3            |     12  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      Lobules, Atrophy                     |                               2                                         1|      7  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
      Mineralization                       |    3                       4              1                              |      4  2.8|
      Ulcer                                | 3                 4        4        1                                    |      5  3.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
      Mineralization                       |    3                    3  4              1                              |      6  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7|            |
                             DAY ON TEST   | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4|            |
                                           | 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    6 MG/M3                                | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                | 3                                                                        |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +                    +  +                                             |   5        |
      Aorta, Mineralization                |    4                    3  3                                             |      5  3.2|
      Mesenteric Artery, Mineralization    |    4                    3  3                                             |      5  3.2|
      Mesenteric Artery, Thrombosis        |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  3  2  2  3  3  2  1  3  3  3  2  2  3  2     1  2  2  2  1  2  1  2  2|     47  1.9|
      Atrium, Thrombosis                   | X                                                                        |      5     |
      Myocardium, Inflammation             |                2                                                         |      1  2.0|
      Myocardium, Mineralization           |    4                    2  4              2                              |      6  2.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                   4                             2           2            |      4  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                      3                          1           2           2|      8  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  M  +  A  +  M  +  M  +  M  +  +  M  +  +  +  +  +  +  A  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  45        |
      Hyperplasia                          |    4  1           2     3  3  2           3                              |     11  2.3|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis, Focal                   |                                                                      4   |      1  4.0|
      Cyst                                 |                                                                          |      1  3.0|
      Pars Distalis, Hyperplasia           |          1                                                  1            |      8  1.4|
      Pars Nervosa, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  46        |
      C-Cell, Hyperplasia                  |    2                                      3                              |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Spermatocele                         | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                               2                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Prostate                                | M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7|            |
                             DAY ON TEST   | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4|            |
                                           | 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    6 MG/M3                                | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                         2        3     3  4  2                 2         |     14  2.6|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                2  4     3                 3  4              3            |     11  3.1|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
      Interstitial Cell, Hyperplasia       |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
      Atrophy, Focal                       |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
      Myelofibrosis                        |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                                        3                                 |      3  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Chronic                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             | 2     4  1  2     3  2  1  3  3  2  2  3  2  3     4  3  2  3  3  3  3  3|     44  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|  48        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                  3                                       |      2  3.0|
      Hyperplasia, Plasma Cell             |                            3                                            3|      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                            3                                             |      3  3.3|
      Hyperplasia, Histiocytic             |    1  3  1  2     3  3  1  3  2     2     2  3     4  3  3  3  3  3  3  2|     40  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  A  +  +  +|  48        |
      Hemorrhage                           |                   3                                                      |      2  3.5|
      Hyperplasia, Lymphoid                |    3                             3                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |    4                                                                     |      5  3.4|
      Fibrosis                             |             3                                                            |      1  3.0|
      Hematopoietic Cell Proliferation     |    3                    3                                                |      2  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  M|  40        |
      Atrophy                              |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7|            |
                             DAY ON TEST   | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4|            |
                                           | 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    6 MG/M3                                | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst Epithelial Inclusion            |                X                                                         |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                            2              X                              |      4  2.0|
      Pelvis, Fracture                     |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      2     |
      Hemorrhage                           |                                  3                                       |      1  3.0|
      Necrosis, Focal                      |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Granulomatous          | 2  1  1  2  2  1  2  2  1  1  2  2  2  1  1  1  1  1  2  3  1  2  1  1  1|     50  1.6|
      Inflammation, Suppurative            |                         4                                                |      2  3.5|
      Mineralization                       |    4                       3              2                              |      4  3.0|
      Alveolar Epithelium, Hyperplasia     |       1     2        2        1  1           1  1  1     2        1  2  1|     26  1.3|
      Interstitium, Fibrosis, Focal        | 1     1  1  1                 1                          1        1  1  4|     16  1.2|
      Interstitium, Mineralization         |                                                                          |      1  3.0|
      Peribronchial, Hyperplasia,          |                                                                          |            |
          Histiocytic                      |             2        2           1                 1     2        1      |     12  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                   1                                                      |      1  1.0|
      Mucosa, Inflammation, Suppurative    |                         3           2                                    |      5  2.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |                                                                1         |      3  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   2        |
      Cataract                             |                               3                                          |      1  3.0|
      Retina, Degeneration                 |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 8| 6| 7| 7| 7| 7| 8| 6| 7| 5| 7| 5| 5| 8| 7| 8| 7| 6| 8| 8| 7|            |
                             DAY ON TEST   | 5| 0| 9| 9| 0| 3| 2| 3| 3| 5| 0| 7| 1| 9| 6| 5| 2| 0| 4| 0| 6| 4| 0| 0| 4|            |
                                           | 0| 4| 9| 9| 0| 3| 8| 9| 4| 7| 0| 3| 5| 3| 2| 8| 9| 0| 1| 0| 1| 8| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 6| 7| 7| 7| 7| 7| 8| 8| 9| 9| 9| 0| 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 3| 3|      A     |
    6 MG/M3                                | 0| 3| 4| 5| 8| 9| 3| 4| 7| 8| 9| 0| 2| 3| 4| 5| 7| 1| 4| 5| 6| 8| 9| 0| 2|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Nephropathy                          | 1  4  3  3  3  1  4  2  4  4  3  3  1     4  1  1  3  2  2  2  1  3  3  2|     47  2.5|
      Medulla, Inflammation                |                                           3                              |      1  3.0|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|             
                                           | 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
    18 MG/M3                               | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                             4            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  A  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation                         |                         3        3  3                                    |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation                         |                                                                          |             
      Mineralization                       |                                                                3         |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  M  M  M  +  +  +  +  +  +  M  A  +  +  +  +  M  +  +  +  A  +  M|             
      Inflammation                         |                                                                          |             
      Metaplasia, Focal, Squamous          |                                              3                           |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation                         |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A|             
      Hyperplasia, Lymphoid                |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Basophilic Focus                     |    2                 2                    1  1  2  2  2  1  2  3         |             
      Clear Cell Focus                     |                                                       1  2               |             
      Degeneration, Cystic                 |                2     1                       2                       1   |             
      Degeneration, Diffuse                |                                                                          |             
      Eosinophilic Focus                   |             1              1  1              1     1                     |             
      Fatty Change                         | 3  1     3     3                 3  4              1        2  3         |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Focal, Necrotizing     |                                                                          |             
      Necrosis, Focal                      |             3                                                            |             
      Bile Duct, Hyperplasia               | 4  2  2  3  4  3  2  1  3  2  4  4  1  1  1  2  2  1  2  1  1  1     2  2|             
      Centrilobular, Atrophy               |                   3           3           3        1                     |             
      Centrilobular, Degeneration, Fatty   |                         4                                                |             
      Centrilobular, Degeneration          |          2                 3     4     1                             3  4|             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Lobules, Atrophy                     |       1                 1     1  3                          3            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperkeratosis                       |                                                                         4|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|             
                                           | 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
    18 MG/M3                               | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                | 3        4                                                  4        4   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Mineralization                       |    3                                                           3         |             
      Ulcer                                |                                     2                       2            |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                        +                       +         |             
      Aorta, Mineralization                |                                                                3         |             
      Mesenteric Artery, Aneurysm          |                                        X                                 |             
      Mesenteric Artery, Inflammation      |                                                                          |             
      Mesenteric Artery, Mineralization    |                                                                          |             
      Mesenteric Artery, Thrombosis        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  2  1  2  1  2  2  1  3  1  1  1  1  2  2  2  2  1  2  1  3  2  2  2|             
      Atrium, Thrombosis                   |             X              X                                   X        X|             
      Myocardium, Mineralization           |    3                                                           3         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Degeneration, Fatty                  |                                                       3                 3|             
      Hyperplasia, Diffuse                 |                                     4                                    |             
      Hyperplasia, Focal                   |    2           1  1                                         2        2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia                          | 2     2           4     4                                            4   |             
      Bilateral, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  M  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  I  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  I  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3                 2                    1  3           3     4         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |    3                    3                    2  4                    2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      C-Cell, Hyperplasia                  |                         4                          2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                         +                       +                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|             
                                           | 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
    18 MG/M3                               | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                                  2                                4      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                                                |             
      Inflammation                         |       2        1     4           2  3              1        2  3  1  1  3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          3        3                 2     4              4  3            |             
      Hyperplasia, Focal, Lymphoid         |                      3                                                   |             
      Interstitial Cell, Hyperplasia       |       1                                                                  |             
      Serosa, Proliferation                |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|             
      Atrophy                              |                                     3                                    |             
      Myelofibrosis                        |                         2                                                |             
      Myeloid Cell, Hyperplasia            |       3           3     2     3                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |    3  2  2     3  3  4  3  3  1  3  2  3  3  4  3  3  4  4  2  3     2  3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  I  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                    3                     |             
      Inflammation, Chronic Active         |                            3  3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |    3  2  3     3  3  3  3  4  2  3  3  3  4  4  3  2  3  4  4  3     3  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Lymphoid                |                                        3                                 |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Chronic Active         |                            3                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Atrophy                              |                                                                         4|             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                                                          |             
      Fibrosis, Focal                      |                         3                    4                           |             
      Hematopoietic Cell Proliferation     |                            3                                   2        2|             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Inflammation, Focal, Granulomatous   |    4                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Inflammation    |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|             
                                           | 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
    18 MG/M3                               | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    X                                                           X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                X                                                         |             
      Infarct                              |                                                 3                        |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                          X               |             
      Inflammation, Granulomatous          | 3  3  2  3     4  4  3  2  3  2  3  3  3  3  4  1  2  2  2  2  2  1  2  2|             
      Alveolar Epithelium, Hyperplasia     |    1     2     2     2  1  2  1     1     2  1  1  2  2  1  2        1  2|             
      Alveolus, Metaplasia, Squamous       |    1                                                                     |             
      Interstitium, Fibrosis, Focal        |    2     3           2  1  3  1  1  1  1  2  2     2  1  2  2  1     1   |             
      Interstitium, Mineralization         |                                                                3         |             
      Peribronchial, Hyperplasia,          |                                                                          |             
          Histiocytic                      |                                                    1  3                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |                                                                          |             
      Mucosa, Inflammation, Suppurative    |                            2                                             |             
      Respiratory Epithelium, Hyperplasia  |    2           2     1                       3                 1        1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
      Cataract                             |          3                                                               |             
      Inflammation, Chronic                |          4                                                               |             
      Cornea, Inflammation, Necrotizing    |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 1  4  2  2  2  3  4  4  3  2  1  2  3     3  4  3  2  1  4  4  4     1   |             
      Medulla, Inflammation                |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 9| 9| 1| 2| 0| 9| 9| 9| 9| 3| 0| 1| 9| 9| 9| 9| 9| 8| 2| 9| 9| 9| 7| 5| 0|             
                                           | 2| 8| 5| 2| 5| 8| 9| 9| 9| 7| 9| 4| 7| 4| 9| 9| 9| 8| 8| 9| 4| 9| 8| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 5| 5| 5| 5| 5| 6| 7| 7| 7| 7| 7| 7| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0|             
    18 MG/M3                               | 5| 6| 9| 0| 1| 2| 5| 6| 9| 2| 4| 5| 6| 7| 8| 0| 3| 4| 5| 6| 7| 8| 1| 2| 3|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                         +                                                |             
      Fibrosis                             |                         3                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8|            |
                             DAY ON TEST   | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0|            |
                                           | 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    18 MG/M3                               | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +  A  +  +  +  +  +  A  A  +  +  A  +  +  +  +  +  A  +  A  +|  37        |
      Inflammation                         |                   2                                         2            |      5  2.6|
      Parasite Metazoan                    |                            X  X                          X        X      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A|  46        |
      Inflammation                         |                3                                                         |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Parasite Metazoan                    |                               X                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  M  +  +  M  M  +  +  +  +  M  A  +  +  +  +  +  +  M  +  +|  34        |
      Inflammation                         |                      1                                                   |      1  1.0|
      Metaplasia, Focal, Squamous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  A  M  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  A|  35        |
      Hyperplasia, Lymphoid                |                      3                                                   |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A|  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Basophilic Focus                     |       2        1  1        1           2  2     1  1     1               |     19  1.6|
      Clear Cell Focus                     |       1                                                  2               |      4  1.5|
      Degeneration, Cystic                 |                2                       1           1  2           1      |      9  1.4|
      Degeneration, Diffuse                | 3                                                                        |      1  3.0|
      Eosinophilic Focus                   |                                                                      2  2|      7  1.3|
      Fatty Change                         | 3                 2        3                                             |     12  2.6|
      Hyperplasia, Focal                   |                                                             3            |      1  3.0|
      Inflammation, Focal, Necrotizing     |    1                                                                     |      1  1.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |    2  1     4  1     2     1  2  2  1  2  2  1  2  3  3  1  3     1  3  2|     44  2.0|
      Centrilobular, Atrophy               |                                                    2        4        3   |      7  2.7|
      Centrilobular, Degeneration, Fatty   |                                                                          |      1  4.0|
      Centrilobular, Degeneration          |             2        4           4                                       |      9  3.0|
      Centrilobular, Necrosis              |                                                                3  3      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                 +                        |   1        |
      Inflammation                         |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lobules, Atrophy                     |             1  1                                            2            |      8  1.6|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8|            |
                             DAY ON TEST   | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0|            |
                                           | 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    18 MG/M3                               | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                3         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperkeratosis                       |                                                                          |      1  4.0|
      Mineralization                       |                4                                                         |      1  4.0|
      Ulcer                                |                   1     4  4                          2                  |      8  3.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Mineralization                       |                4           4                 1                 1         |      6  2.7|
      Ulcer                                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                     +                                    |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                +           +                 +                           |   5        |
      Aorta, Mineralization                |                4           3                 3                           |      4  3.3|
      Mesenteric Artery, Aneurysm          |                                              X                           |      2     |
      Mesenteric Artery, Inflammation      |                4                                                         |      1  4.0|
      Mesenteric Artery, Mineralization    |                4           3                 3                           |      3  3.3|
      Mesenteric Artery, Thrombosis        |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 1  1  3  2  2  2  1  1  2  3  3  1  2  1  2  3  2  1  2  2  1  2  3  2  2|     50  1.8|
      Atrium, Thrombosis                   |          X  X  X           X        X                       X  X         |     11     |
      Myocardium, Mineralization           |                4           3                 2                           |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Degeneration, Fatty                  |                                                                          |      2  3.0|
      Hyperplasia, Diffuse                 | 4                                                                        |      2  4.0|
      Hyperplasia, Focal                   |                                  1              1           2  1         |      9  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia                          |                                           4           2  4               |      8  3.3|
      Bilateral, Hyperplasia               |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
      Hyperplasia                          |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      Hyperplasia                          |                4        2  3              3  3                 2         |     12  2.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |                            X                                             |      1     |
      Pars Distalis, Hyperplasia           |             3                    4                                       |      7  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8|            |
                             DAY ON TEST   | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0|            |
                                           | 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    18 MG/M3                               | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
      C-Cell, Hyperplasia                  |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                               +                                          |   3        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                                                                2         |      1  2.0|
      Inflammation                         |             3                                         3                 2|      5  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                                                          |      1  3.0|
      Inflammation                         |             3  3  2     1                       4  4        3  4         |     19  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              | 3        3        4        4  4     3        2              3  4     3   |     16  3.3|
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  3.0|
      Interstitial Cell, Hyperplasia       | 3           1                                                            |      3  1.7|
      Serosa, Proliferation                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Atrophy                              | 3                                                                        |      2  3.0|
      Myelofibrosis                        |                                                                          |      1  2.0|
      Myeloid Cell, Hyperplasia            |                               3                                          |      6  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Histiocytic             | 4  3  3  2  3  2     4  3  4  3  3  2  3  3  4  3  4  3  3  2  4  3  2  4|     47  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Plasma Cell             |             3        2                                         2     3   |      5  2.6|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  I  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Histiocytic             | 1     4  2  1     4     3  4  3  3  2  3     2  3  2  4  3  2  4  4  3  3|     44  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                      3                             3                     |      3  3.0|
      Hyperplasia, Plasma Cell             |                                                                      3   |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8|            |
                             DAY ON TEST   | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0|            |
                                           | 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    18 MG/M3                               | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                                     3                                    |      2  3.5|
      Autolysis                            |          3                                                               |      1  3.0|
      Cyst                                 |                                              X                           |      1     |
      Fibrosis, Focal                      |                                                                          |      2  3.5|
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  I  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  M|  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcutaneous Tissue, Inflammation    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrous Osteodystrophy               |                X           X                 X                           |      5     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                            X                                             |      2     |
      Infarct                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
      Degeneration                         |    4                                                                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        X                             X   |      3     |
      Inflammation, Granulomatous          | 2  2  2  2  2  4  2  2  2  2  2  2  2  2  4  2  2  2  2  2  2  2  2  2  2|     49  2.3|
      Alveolar Epithelium, Hyperplasia     | 2  1  2  2  1  3  3  2  2  1  1  1     2  3     1  1  2  3  1        2  2|     38  1.7|
      Alveolus, Metaplasia, Squamous       |                                        1                                 |      2  1.0|
      Interstitium, Fibrosis, Focal        | 1  1  3     1  1  4  1  1     1        4  4     1        4        1  1  1|     33  1.8|
      Interstitium, Mineralization         |                3           3                 1                           |      4  2.5|
      Peribronchial, Hyperplasia,          |                                                                          |            |
          Histiocytic                      |    2  2                       2        2                    1           2|      8  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +|  47        |
      Lumen, Hemorrhage                    |                            3                                             |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 2| 8| 7| 6| 7| 6| 6| 8| 7| 8| 6| 7| 8| 8| 6| 7| 6| 6| 8| 6| 7| 7| 8| 8|            |
                             DAY ON TEST   | 3| 4| 0| 4| 1| 0| 8| 5| 0| 8| 0| 0| 9| 0| 0| 4| 1| 1| 5| 0| 7| 9| 9| 0| 0|            |
                                           | 4| 8| 0| 3| 5| 1| 3| 1| 0| 3| 0| 7| 1| 0| 0| 5| 9| 7| 3| 0| 6| 3| 1| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 1| 1| 2| 2| 2| 2| 2| 2| 2| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 7| 7| 7|      A     |
    18 MG/M3                               | 7| 9| 0| 2| 4| 5| 6| 7| 8| 2| 3| 4| 5| 6| 7| 1| 2| 6| 7| 8| 0| 1| 4| 5| 6|      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Inflammation, Suppurative    |                            2                                             |      2  2.0|
      Respiratory Epithelium, Hyperplasia  |       1        2           1  1  1     1              1  1               |     14  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   2        |
      Cataract                             | 2                                                                        |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Cornea, Inflammation, Necrotizing    | 4                                                                        |      1  4.0|
      Retina, Degeneration                 | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Calculus Micro Observation Only      |                                                 X                        |      1     |
      Cyst                                 |                                                                   X      |      1     |
      Hydronephrosis                       |                                                 3                        |      1  3.0|
      Nephropathy                          | 3     4     1  4  1  1  4  4  3     1  2  3  4  2     1  3  1  4  3  3  2|     43  2.6|
      Medulla, Inflammation                |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                 +                        |   1        |
      Calculus Micro Observation Only      |                                                 X                        |      1     |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Fibrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Calculus Gross Observation           |                                                 X                        |      1     |
      Mucosa, Hyperplasia                  |                                                 3                        |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7|        |            |
                             DAY ON TEST   | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3|        |            |
                                           | 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|        |      T     |
                               ANIMAL ID   | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1|        |      A     |
    CONTROL                                | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +  +     +        +  M     +        +  +        +  +            |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Parasite Metazoan                    |    2     X        3                                      2               |      4  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Parasite Metazoan                    |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Parasite Metazoan                    |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Basophilic Focus                     |          1                                   1                           |      2  1.0|
      Fatty Change                         |                                                          1               |      1  1.0|
      Hyperplasia, Focal                   |                                                             3            |      1  3.0|
      Necrosis, Coagulative, Multifocal    |                                                 2                        |      1  2.0|
      Thrombosis                           |                                                 X                        |      1     |
      Bile Duct, Hyperplasia               |          1                    1     1        2           1               |      5  1.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +     +  +     +        +  +     +        +  +           +            |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +     +  +     +        +  +     +        +  +           +            |  10        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Cardiomyopathy                       |          2                    2     1        1           2  2            |      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    M     +  +     +        +  +     +        +  +        +  +            |  10        |
      Hyperplasia                          |          1                                                               |      1  1.0|
      Bilateral, Hyperplasia               |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +  +     +        +  +     +        +  +        A  M            |   9        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    M     +  M     +        +  +     +        M  +        M  M            |   6        |
      Hyperplasia                          |          2                                                               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7|        |            |
                             DAY ON TEST   | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3|        |            |
                                           | 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|        |      T     |
                               ANIMAL ID   | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1|        |      A     |
    CONTROL                                | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Pars Distalis, Hyperplasia           |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      C-Cell, Hyperplasia                  |                                              1                           |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +     +  +     +        +  M     +        +  +        +  M            |   9        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +     +  +     +        +  +     +        +  +        +  M            |  10        |
      Inflammation                         |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Cyst                                 |          X                                                               |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Myeloid Cell, Hyperplasia            |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |    +     M  M     +        +  +     +        +  +        +  +            |   9        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +     +  +     M        +  +     +        +  +        +  +            |  10        |
      Hyperplasia, Lymphoid                |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Congestion                           |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    M     +  +     +        +  +     +        +  +        +  +            |  10        |
      Depletion Lymphoid                   |                               3                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                          3  3            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Congestion, Acute                    |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Atrophy                              |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +  +     M        +  +     +        +  +        +  +            |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 1| 5| 7| 3| 3| 3| 6| 1| 1| 7| 5| 5| 7| 5| 5| 1| 7| 6| 5| 7| 7|        |            |
                             DAY ON TEST   | 3| 9| 5| 3| 3| 2| 3| 6| 7| 9| 3| 8| 5| 3| 9| 5| 9| 3| 0| 5| 3| 3|        |            |
                                           | 1| 2| 5| 8| 3| 0| 3| 0| 3| 2| 8| 4| 6| 1| 3| 6| 4| 0| 1| 6| 8| 0|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4|        |      T     |
                               ANIMAL ID   | 8| 9| 9| 9| 1| 1| 2| 3| 4| 4| 6| 6| 7| 7| 9| 9| 9| 9| 0| 1| 1| 1|        |      A     |
    CONTROL                                | 9| 0| 2| 9| 4| 5| 0| 8| 1| 6| 4| 6| 0| 2| 2| 3| 4| 5| 9| 2| 6| 7|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Inflammation, Granulomatous          |                                              1                           |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                              1                           |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Inflammation, Suppurative            |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Inflammation, Chronic                |                                                             3            |      1  3.0|
      Nephropathy                          |          2                    2                          3  3            |      4  2.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +  +     +        +  +     +        +  +        +  +            |  11        |
      Calculus Gross Observation, Single   |                                                 X                        |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7|        |            |
                             DAY ON TEST   | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3|        |            |
                                           | 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|        |      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3|        |      A     |
    6 MG/M3                                | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +     M     M  M  M     +  +  +  +  +  +  +     +           +         |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Parasite Metazoan                    |    1              2  1              X        1     1                     |      6  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Parasite Metazoan                    |                                     X                                    |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Peyer's Patch, Hyperplasia, Focal,   |                                                                          |            |
           Lymphoid                        |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Basophilic Focus                     | 1        1                          2  1                                 |      4  1.3|
      Inflammation, Focal, Subacute        |    1                                                                     |      1  1.0|
      Bile Duct, Hyperplasia               | 1        1     1  2  1        1  1     1  1                              |      9  1.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Cardiomyopathy                       | 2        2        2  1        2     1  2                       1         |      8  1.6|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Hyperplasia, Focal                   |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Hyperplasia                          | 2                                1                             2         |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Hyperplasia                          |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M     M     M  M  +     +  +  +  +  +  M  M     M           +         |   7        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     +  +  +     +  +  +  +  +  +  +     M           +         |  14        |
      Cyst                                 |                      X                                                   |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7|        |            |
                             DAY ON TEST   | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3|        |            |
                                           | 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|        |      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3|        |      A     |
    6 MG/M3                                | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +     +  +  M     +  +  +  +  +  +  +     M           +         |  13        |
      C-Cell, Hyperplasia                  |          1     1                                                         |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Inflammation                         |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Atrophy                              |                                     2                                    |      1  2.0|
      Interstitial Cell, Hyperplasia       |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Hyperplasia, Histiocytic             |          2                    2                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Hyperplasia, Histiocytic             | 2  2     3     2  2  2     1  2  1  2  2                       3         |     12  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +     +  +  M     +  +  +  M  +  +  M     +           +         |  12        |
      Hyperplasia, Lymphoid                |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M     +     +  M  +     +  +  +  +  +  M  M     +           +         |  11        |
      Hyperplasia, Histiocytic             | 2              2     2     1  2  1  2  2                                 |      8  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Hyperplasia, Histiocytic             |                1                    2                                    |      2  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Infarct                              |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +     +  +  +     +  M  +  +  M  +  +     +           +         |  13        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +     M     +  M  +     +  +  +  +  +  +  +     +           M         |  11        |
      Hyperplasia, Cystic                  |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 1| 5| 7| 7| 5| 3| 5| 7| 1| 7| 5| 7| 7| 3| 3| 6| 1| 6| 5| 6| 7|        |            |
                             DAY ON TEST   | 3| 9| 7| 3| 2| 5| 3| 5| 0| 9| 3| 5| 3| 3| 3| 3| 5| 9| 7| 6| 1| 3|        |            |
                                           | 8| 2| 3| 8| 5| 6| 3| 6| 6| 3| 8| 6| 8| 8| 3| 3| 2| 4| 0| 6| 6| 8|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|        |      T     |
                               ANIMAL ID   | 0| 0| 0| 1| 2| 2| 3| 5| 5| 5| 7| 7| 8| 8| 8| 0| 0| 0| 2| 2| 2| 3|        |      A     |
    6 MG/M3                                | 2| 7| 9| 0| 5| 7| 3| 4| 5| 8| 6| 7| 0| 1| 2| 1| 6| 8| 2| 3| 7| 1|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Inflammation, Granulomatous          | 2  1     2     1  2  2     2  1  1  2  1  1  2     1           1         |     15  1.5|
      Alveolar Epithelium, Hyperplasia     | 1        1     1  2  1        1  1  1  1  2  2                 1         |     12  1.3|
      Interstitium, Fibrosis, Focal        | 1        1     1  1  1        1  1     1     1                 1         |     10  1.0|
      Peribronchial, Hyperplasia,          |                                                                          |            |
          Histiocytic                      |                      1        1  1                 1                     |      4  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Nephropathy                          | 2        2     2     1        3  1  3  2                       1         |      9  1.9|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +     +  +  +     +  +  +  +  +  +  +     +           +         |  15        |
      Calculus Micro Observation Only      |                                                    X                     |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 5| 3| 7| 1| 7| 3| 6| 5| 5| 6| 1| 6| 1| 7| 7| 7| 5| 6| 7|        |            |
                             DAY ON TEST   | 5| 3| 3| 5| 3| 0| 9| 2| 3| 2| 6| 1| 2| 9| 5| 9| 3| 3| 3| 5| 5| 1|        |            |
                                           | 7| 1| 3| 6| 3| 4| 2| 4| 3| 7| 8| 0| 9| 3| 1| 4| 0| 8| 8| 6| 1| 8|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|        |      T     |
                               ANIMAL ID   | 4| 4| 5| 5| 7| 7| 7| 7| 9| 0| 0| 1| 2| 2| 4| 4| 4| 5| 6| 6| 7| 7|        |      A     |
    18 MG/M3                               | 7| 8| 3| 4| 0| 1| 3| 9| 9| 0| 4| 8| 1| 3| 1| 8| 9| 0| 5| 9| 2| 3|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +  +     +     +              +     +     +  M  +               |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Parasite Metazoan                    |             1     2                    1     2                           |      4  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Basophilic Focus                     |          1                             1           1  1                  |      4  1.0|
      Congestion                           |                                                       2                  |      1  2.0|
      Bile Duct, Hyperplasia               |          1                                         2     1               |      3  1.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Cardiomyopathy                       |          1                                            2  1               |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +  +     +     +              +     M     M  +  +               |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Cyst                                 |       X                                                                  |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +     +     +              +     M     M  +  +               |   8        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 5| 3| 7| 1| 7| 3| 6| 5| 5| 6| 1| 6| 1| 7| 7| 7| 5| 6| 7|        |            |
                             DAY ON TEST   | 5| 3| 3| 5| 3| 0| 9| 2| 3| 2| 6| 1| 2| 9| 5| 9| 3| 3| 3| 5| 5| 1|        |            |
                                           | 7| 1| 3| 6| 3| 4| 2| 4| 3| 7| 8| 0| 9| 3| 1| 4| 0| 8| 8| 6| 1| 8|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|        |      T     |
                               ANIMAL ID   | 4| 4| 5| 5| 7| 7| 7| 7| 9| 0| 0| 1| 2| 2| 4| 4| 4| 5| 6| 6| 7| 7|        |      A     |
    18 MG/M3                               | 7| 8| 3| 4| 0| 1| 3| 9| 9| 0| 4| 8| 1| 3| 1| 8| 9| 0| 5| 9| 2| 3|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +  I     +     I              +     +     +  +  +               |   8        |
                                            __________________________________________________________________________|____________|
   Prostate                                |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Inflammation                         |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Testes                                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Atrophy                              |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Hyperplasia, Histiocytic             |       3  2  2     3     2              3     3     4  4  2               |     10  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       M  +  +     +     +              +     +     +  +  +               |   9        |
      Hyperplasia, Lymphoid                |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Congestion                           |       2                                                                  |      1  2.0|
      Hyperplasia, Histiocytic             |          3  2     2     2              3              4  2               |      7  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Atrophy                              |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +  +  +     +     +              +     +     +  +  M               |   9        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M  +  +     +     +              +     +     +  +  +               |   9        |
      Lobules, Hyperplasia                 |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +  +     +     +              +     +     +  +  +               |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +  +     +     +              +     +     +  +  +               |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +  +     +     +              +     +     +  +  +               |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Inflammation, Granulomatous          |       3  2  3     3     3              2     2     3  1  2               |     10  2.4|
      Alveolar Epithelium, Hyperplasia     |       1  1  2           2                          2  1  1               |      7  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05079-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                                TALC                                           Date: 04/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:39:13  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 3| 5| 3| 7| 1| 7| 3| 6| 5| 5| 6| 1| 6| 1| 7| 7| 7| 5| 6| 7|        |            |
                             DAY ON TEST   | 5| 3| 3| 5| 3| 0| 9| 2| 3| 2| 6| 1| 2| 9| 5| 9| 3| 3| 3| 5| 5| 1|        |            |
                                           | 7| 1| 3| 6| 3| 4| 2| 4| 3| 7| 8| 0| 9| 3| 1| 4| 0| 8| 8| 6| 1| 8|        |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|        |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|        |      T     |
                               ANIMAL ID   | 4| 4| 5| 5| 7| 7| 7| 7| 9| 0| 0| 1| 2| 2| 4| 4| 4| 5| 6| 6| 7| 7|        |      A     |
    18 MG/M3                               | 7| 8| 3| 4| 0| 1| 3| 9| 9| 0| 4| 8| 1| 3| 1| 8| 9| 0| 5| 9| 2| 3|        |      L     |
    LUNG TOX                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|        |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Interstitium, Fibrosis, Focal        |       1  1  1           1                          2  1  2               |      7  1.3|
      Peribronchial, Hyperplasia,          |                                                                          |            |
          Histiocytic                      |          1        2                          2     2     1               |      5  1.6|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Respiratory Epithelium, Hyperplasia  |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +  +     +     +              +     +     +  +  +               |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                   +                                                      |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +  +     +     +              +     +     +  +  +               |  10        |
      Nephropathy                          |          1                                         2  4                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +  +     +     +              +     +     M  +  +               |   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
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                             ----------              END OF REPORT             ----------                                           
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