National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2509

TDMS Study 05079-01 Pathology Tables


NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: LITRI                                                     DATE: 09/10/94   
EXP: 05079                          TALC                       TIME: 15:25:36   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 06008    
CONT:                                                          CAS: 14807966    
PATHOLOGIST: B. JONES                        F. HAHN                            
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: LITRI                                                     DATE: 09/10/94  
EXP: 05079                          TALC                       TIME: 15:25:36  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 06008   
CONT:                                                          CAS: 14807966   
PATHOLOGIST: B. JONES                        F. HAHN                           

                                       TALC


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 799 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 41     CENSORED DEATHS 0    TERMINAL 9         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      334   360   429   499   551   568   586   590   593   622                 |
 |      628   631   635   650   656   670   682   682   698   700                 |
 |      700   704   709   724   739   740   741   745   746   747                 |
 |      759   761   764   766   782   784   785   786   787   790                 |
 |      795                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = CONTROL LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 22     UNCENSORED DEATHS 11     CENSORED DEATHS 11   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      173   320   331   555   584   593   601   660   730   730                 |
 |      731                                                                       |
 |  CENSORED DEATHS                                                               |
 |      192   192   194   333   333   556   556   556   738   738                 |
 |      738                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 6 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 36     CENSORED DEATHS 0    TERMINAL 14        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      186   527   529   544   558   573   593   593   604   611                 |
 |      633   648   650   657   663   673   677   690   715   722                 |
 |      728   734   739   740   741   746   747   757   759   761                 |
 |      762   780   781   783   787   791                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                       TALC


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 799 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 6 MG/M3 LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 22     UNCENSORED DEATHS 7      CENSORED DEATHS 15   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      566   573   616   652   670   706   725                                   |
 |  CENSORED DEATHS                                                               |
 |      192   193   194   333   333   333   556   556   556   738                 |
 |      738   738   738   738   738                                               |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 18 MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 34     CENSORED DEATHS 0    TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      248   492   500   594   607   609   614   615   615   617                 |
 |      628   634   645   651   651   653   676   683   697   698                 |
 |      701   705   719   722   737   743   778   783   788   791                 |
 |      791   793   794   798                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 18 MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 22     UNCENSORED DEATHS 12     CENSORED DEATHS 10   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      510   557   568   627   629   651   651   704   718   724                 |
 |      730   731                                                                 |
 |  CENSORED DEATHS                                                               |
 |      192   193   194   333   333   333   556   556   738   738                 |
 |                                                                                |
 ==================================================================================

                                       TALC


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 799 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   799 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  96.0  96.0  94.0  92.0  82.0  70.0  18.0      |
 |           |                                                                    |
 |           |                                                                    |
 |CONTROL    |   100.0  95.5  95.5  84.8  84.8  84.8  84.8  55.2  47.3   0.0      |
 |LUNG TOX   |                                                                    |
 |           |                                                                    |
 |6 MG/M3    |   100.0 100.0  98.0  98.0  98.0  98.0  92.0  82.0  70.0  28.0      |
 |           |                                                                    |
 |           |                                                                    |
 |6          |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  84.6  69.2   0.0      |
 |MG/M3 LUNG |OX                                                                  |
 |           |                                                                    |
 |18 MG/M3   |   100.0 100.0  98.0  98.0  98.0  98.0  94.0  92.0  68.0  32.0      |
 |           |                                                                    |
 |           |                                                                    |
 |18         |   100.0 100.0 100.0 100.0 100.0 100.0  93.8  79.3  50.5   0.0      |
 |MG/M3LUNG T|X                                                                   |
 |           |                                                                    |
 ==================================================================================

                                       TALC


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 799 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                          DOSE                                               |
 |                                                                                                                             |
 |                                CONTROL         CONTROL         6 MG/M3         6               18 MG/M3        18           |
 |                                                LUNG TOX                        MG/M3 LUNG TOX                  MG/M3LUNG TOX|
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       18.0%            0.0%           28.0%            0.0%           32.0%            0.0%        |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.342N         -----          P=0.422N        P=1.000         P=0.192N        P=0.061      |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       673.6           546.2           671.7           644.0           669.7           650.0        |
 |NATURAL DEATHS (C)      |       (17.8)          (57.1)          (19.3)          (23.4)          (18.9)          (21.7)       |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       696.2           506.1           707.4           553.7           711.1           543.9        |
 |(STANDARD ERROR)        |       (16.1)          (44.1)          (16.1)          (42.1)          (15.4)          (41.0)       |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                       TALC


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 862 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 39     CENSORED DEATHS 0    TERMINAL 11        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      370   390   398   558   568   584   586   599   626   634                 |
 |      647   677   678   688   696   716   719   727   731   762                 |
 |      766   767   768   772   779   786   789   800   805   808                 |
 |      813   816   817   824   827   835   841   846   859                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = CONTROL LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 22     UNCENSORED DEATHS 7      CENSORED DEATHS 14   TERMINAL 1         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      180   450   622   673   716   718   728                                   |
 |  CENSORED DEATHS                                                               |
 |      192   193   194   333   333   333   556   556   556   739                 |
 |      739   739   739   739                                                     |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 6 MG/M3                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 36     CENSORED DEATHS 1    TERMINAL 13        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      482   508   526   557   561   566   566   647   651   668                 |
 |      678   690   697   705   720   724   729   738   740   747                 |
 |      755   760   762   766   768   786   798   798   799   800                 |
 |      812   815   818   819   841   849                                         |
 |  CENSORED DEATHS                                                               |
 |      820                                                                       |
 |                                                                                |
 ==================================================================================

                                       TALC


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 862 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 6 MG/M3 LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 22     UNCENSORED DEATHS 4      CENSORED DEATHS 18   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      510   625   716   734                                                     |
 |  CENSORED DEATHS                                                               |
 |      192   193   194   333   333   333   556   556   556   739                 |
 |      739   739   739   739   739   739   739   739                             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 18 MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 41     CENSORED DEATHS 0    TERMINAL 9         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      536   558   586   594   615   633   646   660   661   675                 |
 |      676   678   684   693   697   706   710   716   717   724                 |
 |      739   740   746   747   773   784   786   796   803   822                 |
 |      823   828   829   835   841   841   842   848   850   854                 |
 |      857                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 18 MG/M3LUNG TOX                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 22     UNCENSORED DEATHS 10     CENSORED DEATHS 12   TERMINAL 0         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      376   558   594   621   621   648   650   677   698   726                 |
 |  CENSORED DEATHS                                                               |
 |      192   193   194   333   333   333   556   556   556   739                 |
 |      739   739                                                                 |
 |                                                                                |
 ==================================================================================

                                       TALC


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 862 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   862 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0  94.0  94.0  94.0  84.0  78.0  22.0      |
 |           |                                                                    |
 |           |                                                                    |
 |CONTROL    |   100.0  95.5  95.5  95.5  95.5  89.1  89.1  89.1  81.0  48.6      |
 |LUNG TOX   |                                                                    |
 |           |                                                                    |
 |6 MG/M3    |   100.0 100.0 100.0 100.0 100.0  98.0  94.0  86.0  82.0  27.7      |
 |           |                                                                    |
 |           |                                                                    |
 |6          |   100.0 100.0 100.0 100.0 100.0 100.0  93.8  93.8  85.9   0.0      |
 |MG/M3 LUNG |OX                                                                  |
 |           |                                                                    |
 |18 MG/M3   |   100.0 100.0 100.0 100.0 100.0 100.0  98.0  92.0  82.0  18.0      |
 |           |                                                                    |
 |           |                                                                    |
 |18         |   100.0 100.0 100.0 100.0  93.8  93.8  93.8  78.1  46.9   0.0      |
 |MG/M3LUNG T|X                                                                   |
 |           |                                                                    |
 ==================================================================================

                                       TALC


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 862 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                          DOSE                                               |
 |                                                                                                                             |
 |                                CONTROL         CONTROL         6 MG/M3         6               18 MG/M3        18           |
 |                                                LUNG TOX                        MG/M3 LUNG TOX                  MG/M3LUNG TOX|
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       22.0%           48.6%           27.7%            0.0%           18.0%            0.0%        |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.390          -----          P=0.805N        P=0.716N        P=0.977         P=0.017      |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       709.5           583.9           712.4           646.3           735.3           616.9        |
 |NATURAL DEATHS (C)      |       (20.4)          (76.6)          (16.9)          (51.3)          (14.0)          (31.0)       |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       743.1           540.5           753.4           567.4           758.1           528.7        |
 |(STANDARD ERROR)        |       (18.2)          (47.7)          (15.4)          (44.3)          (13.4)          (40.3)       |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                                TALC
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        CONTROL LUNG TOX = 2
                                                        6 MG/M3          = 3
                                                        6 MG/M3 LUNG TOX = 4
                                                        18 MG/M3         = 5
                                                        18 MG/M3LUNG TOX = 6

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

  100 +  1                        2 3        5           1                        6       4
      |                             3        5           1   1                  5    3
      |                           2                    2     1         1        516  3 3 6    5
      |                                                                          1     31344  5 5
   90 +                                                2 2                              13 1
      |                                                                                  6 1 13 55
      |                                                  2                               2 4 11 34
      |                                                                                       1 331
   80 +                                                                                  2 6 2   3113
      |                                                                                          4 11 34
      |                                                                                             1 13
      |                                                                                               113
P  70 +                                                                                      22       51313
E     |                                                                                                5 151
R     |                                                                                            6  6   3131  3
C     |                                                                                       22         4    4 33
E  60 +                                                                                                      55
N     |                                                                                                      11  33
T     |                                                                                        2        2     115133
      |                                                                                                          1 1
S  50 +                                                                                               6       6    33
U     |                                                                                                 2         2 5    5
R     |                                                                                                          4 11 3  55
V     |                                                                                                       6 6
I  40 +                                                                                                             1 1
V     |                                                                                                               3  355
A     |                                                                                                         66    11
L     |                                                                                                                1 1355
   30 +                                                                                                          66
      |                                                                                                                  11 3
      |
      |                                                                                                           22
   20 +                                                                                                                   11
      |                                                                                                                    11
      |                                                                                                           66
      |
   10 +
      |
      |
      |
    0 +                                                                                                            2
      ---+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+--
         0        10        20        30        40        50        60        70        80        90        100       110       120

                                                                   WEEK

NOTE: 48 obs hidden.

                                                                TALC
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        CONTROL LUNG TOX = 2
                                                        6 MG/M3          = 3
                                                        6 MG/M3 LUNG TOX = 4
                                                        18 MG/M3         = 5
                                                        18 MG/M3LUNG TOX = 6

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

         100 +  1                   2                   16          3  4  5
             |                                          1 1         3  3  5 5
             |                      2                    611     2     3 3  1  55   4
             |                                                              131 5 5
          90 +                                                   2            11  525
             |                                                                      5 5
             |                                                              63 161  1 35     4
             |                                                                      1 3535
          80 +                                                                     21 1 32
             |                                                                  6  6  1  13  4 4
             |                                                                           1133
             |                                                                           21132
       P  70 +                                                                             151344
       E     |                                                                              5533
       R     |                                                                               1113
       C     |                                                                     6  6      5513 1
       E  60 +                                                                                5 3311
       N     |                                                                               22  33
       T     |                                                                                  5 31
             |                                                                                  5  11
       S  50 +                                                                                     311
       U     |                                                                        6  6    2     533      2
       R     |                                                                                       11
       V     |                                                                                        11 5
       I  40 +                                                                           6 6          311
       V     |                                                                                         335
       A     |                                                                                          115
       L     |                                                                             6  6         3153
          30 +                                                                                           1133
             |                                                                                            1133
             |                                                                                             11
             |                                                                                6 6           11
          20 +                                                                                              5
             |                                                                                              55
             |
             |
          10 +
             |
             |
             |
           0 +                                                                                  4
             ---+--------------+--------------+--------------+--------------+--------------+--------------+--------------+--
                0             20             40             60             80             100            120            140

                                                                   WEEK

NOTE: 60 obs hidden.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.