National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2519

TDMS Study 05080-02 Pathology Tables

NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11




       Facility:  Battelle Northwest

       Chemical CAS #:  106-92-3

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 7| 6| 2| 2| 8| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          3                                                               |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Chronic, Multifocal    | 1                                                                        |             
      Leukocytosis                         |                                                                          |             
      Hepatocyte, Cytomegaly               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                             +     +      |             
      Hyperplasia, Lymphoid                |                                                             4            |             
      Inflammation, Suppurative            |                                                                          |             
      Fat, Necrosis                        |                               3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                3                                               3     2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Duct, Ectasia                        |                3                                                         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             4            |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                                                   2      |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                                                                   3      |             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 7| 6| 2| 2| 8| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Atrium, Inflammation, Focal,         |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcapsular, Hyperplasia             | 2  3  2  2  2  2     2  2  2  2  2  2  1  2     2  3     2  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                          X               |             
      Cyst                                 |                                                                         X|             
      Degeneration                         | 2              1     1  1  2  2  1  2  1  1     1  2     1  2  2  1  1  1|             
      Fibrosis                             | 2              1     1  1  1  1  1  1  1  1     1  1     1  2  1  1     1|             
      Hematopoietic Cell Proliferation     |                               1                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  M  M  M  +  M  +  +  M  +  +  M  +  +  M  M  M  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                         3                          1        2        2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   2                                                      |             
      Follicle, Degeneration               |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                    +                     |             
      Abscess                              |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                   +      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X                                      X     X  X     X  X  X|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 2  3  2     3  2     2  2  2  2  1  3  2  2     2  3  2  2  2  2  2  2  2|             
      Endometrium, Inflammation, Acute     |          3                                                               |             
      Endometrium, Inflammation,           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 7| 6| 2| 2| 8| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
          Suppurative                      |                                                    2                     |             
      Endometrium, Necrosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                3         |             
      Myelofibrosis                        | 2  2  2     3     2  2  2  2     2  3  2  3     2  2  1  2  2     2  3  1|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesenteric, Hyperplasia, Lymphoid    |                4                                                         |             
      Renal, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  M  +  M  +  M  +  +  M  +  +  +  M  +  +  +  M  +  +  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                4                    2                       4            |             
      Inflammation, Suppurative            |                                                                          |             
      Pigmentation, Hemosiderin            |    2                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                               3                                   3      |             
      Hyperplasia, Lymphoid                | 3              4           3              2                 4            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  +  +  +  M  M  M  +  +  +  +  M  M  +  M  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hyperplasia, Lymphoid                |                4                                                         |             
      Inflammation, Necrotizing            |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Hair Follicle, Atrophy               |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Atrophy                |                                                 4        3     2        2|             
      Lateral Ventricle, Dilatation        |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 3| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 9| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 4| 3| 3| 3| 3| 3| 3|             
                                           | 2| 2| 7| 6| 2| 2| 8| 2| 2| 2| 4| 2| 2| 2| 8| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Thalamus, Mineralization             |             2                 2                                      2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia, Focal       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                             4            |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic, Multifocal    | 2  2  2        1     2     2        1                 2                  |             
      Leukocytosis                         |                                                                          |             
      Bronchiole, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Hyperplasia                  | 1  1  1  1  1     1  1  1     1  1  1  1     1  1  1     2  1  1  1  2  2|             
      Mucosa, Inflammation, Acute          |                   2                                                      |             
      Mucosa, Inflammation                 |                                  1                                       |             
      Mucosa, Inflammation, Suppurative    |                         1     1                                1         |             
      Olfactory Epithelium, Metaplasia     |                   1                             1                 1      |             
      Respiratory Epithelium, Regeneration |                   1                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Inflammation, Suppurative    |                                                                          |             
      Mediastinum, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                              M                 +         |             
      Inflammation, Necrotizing            |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                4                                            4            |             
      Inflammation, Chronic                | 1  2                          1                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Cortex, Infarct                      |                                                                          |             
      Renal Tubule, Regeneration, Focal    |                                                                          |             
      Renal Tubule, Regeneration           | 1                                         2                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Hyperplasia, Lymphoid                |                4                                            4            |             
      Inflammation, Chronic                | 2                    2     2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 8| 2| 3| 9| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 4| 3| 8| 3|            |
                                           | 1| 3| 2| 3| 2| 8| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2| 2| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  A  +  A  +  A  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  I  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     | 2                             3                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                            2                                             |      1  2.0|
      Inflammation, Chronic, Multifocal    |                                                          1  2        1   |      4  1.3|
      Leukocytosis                         |          X                                                               |      1     |
      Hepatocyte, Cytomegaly               | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +     +              +  +     +     +  +     +     +              +|  13        |
      Hyperplasia, Lymphoid                |       4                                                                  |      2  4.0|
      Inflammation, Suppurative            |                            3  3                                          |      2  3.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      3  2.7|
      Hyperplasia, Lymphoid                |       4           4                                                      |      2  4.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Inflammation, Chronic, Multifocal    |                               2        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma                            |                                                                          |      1  2.0|
      Hyperkeratosis                       |          2                                                               |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 8| 2| 3| 9| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 4| 3| 8| 3|            |
                                           | 1| 3| 2| 3| 2| 8| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2| 2| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                                   +     +                  |   3        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |             4                                                            |      1  4.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                 3     3                  |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis, Focal                      |                            2                                             |      1  2.0|
      Inflammation, Chronic                |                               2                                          |      1  2.0|
      Atrium, Inflammation, Focal,         |                                                                          |            |
          Suppurative                      | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Subcapsular, Hyperplasia             |    2  2        2  2  2  2  2  2  2  2  2  2  2  1  2     2  2     2  2  1|     42  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Accessory Adrenal Cortical Nodule    |                                                             X            |      2     |
      Cyst                                 |                                                                          |      1     |
      Degeneration                         |    1  1           2  2  1  2  2  1  1  2  2  1  1  3     2  2     1  2  1|     37  1.5|
      Fibrosis                             |    1  1           1  1  1  2  1  1  1  1  1  1  1  2     1  1     1  2  1|     36  1.1|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  M  M  M  +  M  +  +  M  M  +  M  +  +  +  +  +  M|  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  I  +  +  +|  44        |
      Pars Distalis, Cyst                  |                                  X                                       |      1     |
      Pars Distalis, Hyperplasia           |             2        3     2  2  2     2  2     2                 2     2|     15  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                                                          |      1  2.0|
      Follicle, Degeneration               |                   2                                                      |      1  2.0|
      Follicular Cell, Hyperplasia         |                      2  2           2                                    |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |             +                       +        +           +               |   5        |
      Abscess                              |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 8| 2| 3| 9| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 4| 3| 8| 3|            |
                                           | 1| 3| 2| 3| 2| 8| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2| 2| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 |             X        X  X           X        X     X                    X|     14     |
      Inflammation, Suppurative            | 4        4                 4  4                                          |      4  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     |    1  2        2  3     2     1  1     2     1     2     2  2     2  3   |     36  2.0|
      Endometrium, Inflammation, Acute     |                                                                          |      1  3.0|
      Endometrium, Inflammation,           |                                                                          |            |
          Suppurative                      | 3        3                                                               |      3  2.7|
      Endometrium, Necrosis                |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Leukocytosis                         |                               X                                          |      1     |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Myelofibrosis                        |    2  2     2  2  2  3  3        1     2  2  2     1     2  2     2     2|     36  2.1|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Mesenteric, Hyperplasia, Lymphoid    |                                                                          |      1  4.0|
      Renal, Inflammation, Suppurative     |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  M  +  +  +  +|  38        |
      Hyperplasia, Lymphoid                |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|  42        |
      Cyst                                 |                                                                   X      |      1     |
      Hyperplasia, Lymphoid                |       4           4  2                                      4        4   |      8  3.5|
      Inflammation, Suppurative            |                               3                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                       3                  |      1  3.0|
      Hematopoietic Cell Proliferation     | 3        4                    3                                      3   |      6  3.2|
      Hyperplasia, Lymphoid                |       4           4                                         4            |      8  3.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  M  +  +  +  +  M  +  M  +  M  +  +  +  M  +  +  M  +  +  +  M  +|  34        |
      Atrophy                              |                                                       3                  |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Inflammation, Necrotizing            |                            3                                             |      1  3.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      | 4                                                                        |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 8| 2| 3| 9| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 4| 3| 8| 3|            |
                                           | 1| 3| 2| 3| 2| 8| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2| 2| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  +  M  +  +  M  +  +  M  M  +  +  +  M  M  +  +  M  M  +  M  +  M|  35        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                               4                                          |      1  4.0|
      Hair Follicle, Atrophy               |                      3           3           3     3                     |      5  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypothalamus, Atrophy                |                         2                                                |      5  2.6|
      Lateral Ventricle, Dilatation        |                                                                          |      1  3.0|
      Thalamus, Mineralization             |                      2              2                                    |      5  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |       4           4                                                      |      3  4.0|
      Inflammation, Acute, Focal           |                            2                                             |      1  2.0|
      Inflammation, Chronic, Multifocal    | 2                 1  2  3        2     2                 2  2        2   |     17  1.9|
      Leukocytosis                         |          3                    3                                          |      2  3.0|
      Bronchiole, Hyperplasia              |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Glands, Hyperplasia                  |    2              1     2  1  1  1           2           1  1     1     1|     32  1.2|
      Mucosa, Inflammation, Acute          |                                                                          |      1  2.0|
      Mucosa, Inflammation                 |                                                                          |      1  1.0|
      Mucosa, Inflammation, Suppurative    |             2           2     1                 2     3                  |      8  1.6|
      Olfactory Epithelium, Metaplasia     |                   2     2     2              1                           |      7  1.4|
      Respiratory Epithelium, Regeneration |             3     2                             2     2                  |      5  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Inflammation, Suppurative    |                      1                                                   |      1  1.0|
      Mediastinum, Inflammation,           |                                                                          |            |
          Suppurative                      |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 6| 7| 7| 7| 4| 5| 7| 7| 7| 7| 7| 2| 7| 0| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 8| 2| 3| 9| 3| 5| 3| 3| 3| 8| 7| 3| 3| 3| 3| 3| 2| 3| 6| 3| 3| 4| 3| 8| 3|            |
                                           | 1| 3| 2| 3| 2| 8| 2| 2| 2| 7| 9| 2| 2| 2| 2| 2| 7| 2| 8| 2| 2| 2| 2| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Inflammation, Necrotizing            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                   4                                         4            |      4  4.0|
      Inflammation, Chronic                | 2                    2  2        2     2                             2  1|     10  1.7|
      Inflammation, Suppurative            |                            2  2                                          |      2  2.0|
      Cortex, Infarct                      |                                           2                              |      1  2.0|
      Renal Tubule, Regeneration, Focal    |                         2                                                |      1  2.0|
      Renal Tubule, Regeneration           |                                  1                          1     1      |      5  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                   4                                                      |      3  4.0|
      Inflammation, Chronic                |                2     2  2  2  2  2                                   1   |     10  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 3| 3| 5| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A  +           +                    +                 A            |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  M           M                    +                 +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  M           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       A  +     +     +                    +                 +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       A  +           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       A  M     +     +                    +                 +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       A  +           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +     +     +           +  +     +           +     +           +|             
      Basophilic Focus                     |                                                                          |             
      Cyst                                 |                                  X                                       |             
      Hematopoietic Cell Proliferation     |       1                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  M           +                    +                 +            |             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +           +                    +                 +            |             
      Inflammation, Chronic, Multifocal    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +           +           +        +                 +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +           +           +        +                 +            |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +           +           +        +                 +            |             
      Atrophy, Focal                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +           +                    +                 +            |             
      Myocardium, Inflammation, Chronic    |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       M  +           +  +                 +                 +            |             
      Subcapsular, Hyperplasia             |          2           2                    2                 2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       M  +           +  +                 +                 +            |             
      Degeneration                         |                      2                    2                 2            |             
      Fibrosis                             |                      2                    2                 2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       M  I           +  +                 +                 +            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  M           +                    +                 +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 3| 3| 5| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       M  M           M                    +                 +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +  +  +  +           +        +                 +           +|             
      Pars Distalis, Hyperplasia           |          3  2                             2                 3            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +        +  +                    +                 +            |             
      Follicular Cell, Hyperplasia         |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  M     +     +              +  +  +              +  +           +|             
      Cyst                                 |                X     X              X  X                 X              X|             
      Inflammation, Suppurative            |                                     4                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +     +  +  +  +     +     +  +     +        +  +         |             
      Endometrium, Hyperplasia, Cystic     | 3  3  2     2  2     2  2  2  2     4     2  2     2        2  2         |             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |       4                             4                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +  +           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +     +  +  +  +           +     +  +  +  +  +  +  +  +   |             
      Myelofibrosis                        | 2  2  2  2  1  3        2  2  3                 3  3  2  3  3  2  2  2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |       M  +           +                    M                 +            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +  +           M                    +                 M            |             
      Infiltration Cellular, Histiocyte    |       3                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +           +              +     +           +     +  +        +|             
      Hematopoietic Cell Proliferation     |       3                             3     3                              |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +           +                    +                 +            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       M  +           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +     +     +        +  +     +  +                 +           +|             
      Hair Follicle, Atrophy               |                2              3        3                                3|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                                  |             
      Back, Inflammation, Chronic          |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +           +                    +                 +            |             
      Thalamus, Mineralization             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 6| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 3| 3| 5| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 1| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |       +  +           +                    +                 +            |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +           +                    +                 +            |             
      Inflammation, Chronic, Multifocal    |       2                                                                  |             
      Leukocytosis                         |                                           4                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Hyperplasia                  | 3  3  1  2  3  3  3     3  2  3  2  2  3  1     3  3  3  3  2  3  3  3  3|             
      Glands, Inflammation                 |                                              3                           |             
      Glands, Regeneration                 |                                                                          |             
      Mucosa, Inflammation, Suppurative    | 2  2  1  1  1  1  2  1  1  1  2  2  2  1     1  2  2  2  2  1  2  1  2  1|             
      Olfactory Epithelium, Metaplasia     | 3  3  1  1  2  2  3  1  2  2  3  3  2  2     3  2  3  3  3  2  3  3  2  2|             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Basal Cell                      |                   2                             1                        |             
      Respiratory Epithelium, Hyperplasia  | 1  1  2  1  2  2  1  1  2  2  2  2     1     2  1     1  1  1  1  2  1  2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                         2     2              2                           |             
      Respiratory Epithelium, Regeneration | 2  3  3  3     2  2  2  2  2  3  3  2  3     3  3  2  1  2  3  1  2  2  3|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +           +                    +                 +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +           +                    +                 +            |             
      Inflammation, Chronic                |                                                             1            |             
      Inflammation, Suppurative            |                                           2                              |             
      Cortex, Cyst                         |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +           +                    +                 +            |             
      Inflammation, Chronic                |       2                                                     2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                               +     +                          +  +      |   9        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                               +     +                          +  A      |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                               +     +                          +  +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                               M     +                          +  M      |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                               +     +                          +  +      |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                               +     +                          +  +      |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                               +     +                          +  A      |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                               +     +                          +  A      |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                               +     +                          +  A      |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                               +     +                          +  A      |   7        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                         +     +     +                          +  +      |  15        |
      Basophilic Focus                     |                         3                                                |      1  3.0|
      Cyst                                 |                               X                                          |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                          +                             +         |   4        |
      Inflammation, Chronic                |       3                                                                  |      1  3.0|
      Fat, Necrosis                        |                                  4                                       |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +                       +  +  +                          +  +      |  10        |
      Atrophy                              |       3                                                                  |      1  3.0|
      Cyst                                 |                                  X                                       |      1     |
      Hyperplasia, Lymphoid                |       4                                                                  |      1  4.0|
      Inflammation, Chronic                |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                               +     +                          +  +      |   9        |
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                            +  +     +                    +     +  +      |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                            +  +     +                    +     +  +      |  12        |
      Hyperkeratosis                       |                                                          3               |      1  3.0|
      Hyperplasia                          |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                               +     +                    +     +  A      |  10        |
      Atrophy, Focal                       |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                               +     +                          +  +      |   9        |
                                            __________________________________________________________________________|____________|
   Heart                                   |                               +     +                          +  +      |   9        |
      Myocardium, Inflammation, Chronic    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                               +     +                          +  +      |   9        |
      Subcapsular, Hyperplasia             |                               2     2                          2  1      |      8  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                               +     +                          +  A      |   8        |
      Degeneration                         |                               2     2                                    |      5  2.0|
      Fibrosis                             |                               2     2                                    |      5  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                               +     +                          +  A      |   7        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                               +     +                          +  +      |   8        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                               M     M                          +  M      |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +                       +     +     +                 +        +  +      |  17        |
      Pars Distalis, Hyperplasia           | 2                                                              2         |      6  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                               +     +                          +  +      |  10        |
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |             +     +           +  +  +     +           +        +  +  +   |  19        |
      Cyst                                 |                                  X        X           X              X   |     10     |
      Inflammation, Suppurative            |             2     2                                                      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +                 +  +  +  +                    +     +  +      |  24        |
      Endometrium, Hyperplasia, Cystic     |          3                 2  2     2                    1     3  1      |     22  2.2|
      Endometrium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                               +     +                          +  +      |   9        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +  +  +           +     +  +  +  +  +           +  +  +  +   |  35        |
      Myelofibrosis                        |    1  1  3  3  2  3           2     2  3  2  2  3           3  3     2   |     32  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +     +                 +        +  +     +|  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |                               +     +                          M  +     +|   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                               +     M                          +  M     +|   6        |
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +        +                 +     +                 +        +  +     +|  18        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                               +     M                          +  +      |   8        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                               +     +                          +  +      |   8        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +     +        +     +        +                 +  +     +|  18        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hair Follicle, Atrophy               |                3     2                       3                          3|      8  2.8|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                               +     +                          +  +      |   9        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Back, Inflammation, Chronic          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                               +     +                          +  +      |   9        |
      Thalamus, Mineralization             |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                               +     +                          +  +      |   9        |
                                            __________________________________________________________________________|____________|
   Lung                                    |                               +     +                          +  +      |   9        |
      Inflammation, Chronic, Multifocal    |                                     2                                    |      2  2.0|
      Leukocytosis                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  49        |
      Glands, Hyperplasia                  | 2  2  3  3  2  3  2  3     3  2  3  2  3  3  3  3  3  3  3  3  3     1  3|     46  2.6|
      Glands, Inflammation                 |                                                                          |      1  3.0|
      Glands, Regeneration                 |                         3                                                |      1  3.0|
      Mucosa, Inflammation, Suppurative    | 2  1  2  1  1  2  2  2  2  2  2  2  1  1  1  2  2  3  1  2  1  2     2  2|     48  1.6|
      Olfactory Epithelium, Metaplasia     | 3  1  3  1  1  3  3  2  3  2  2  3  1  2  2  3  3  3  2  3  2  3     2  3|     48  2.3|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Basal Cell                      |                                                                          |      2  1.5|
      Respiratory Epithelium, Hyperplasia  | 2  1  2  2  2  1  2  1              1  1  1  1  1  2     1     2        2|     39  1.5|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                1     1     2                 2  2     2                  |      9  1.8|
      Respiratory Epithelium, Regeneration | 2  1  2  2  2  1  2  2  2  2  2  2  2  2  2  2  3  2  2  1  2  3     1  2|     47  2.1|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                               +     +                          +  +      |   9        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                +              +     +                          +  A     +|  10        |
      Inflammation, Chronic                |                2                    1                                    |      3  1.3|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Cortex, Cyst                         |                                                                X         |      1     |
      Renal Tubule, Necrosis               |                                     2                                    |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 1| 6| 3| 3|            |
                                           | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 7| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                               +     +                          +  +      |   9        |
      Inflammation, Chronic                |                               1                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 7| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  M  +  +  A  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                3         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +     +                                         +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Fat, Necrosis                        |                         2                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           4                              |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                     3           3                        |             
      Hyperplasia                          |       1                             3                                    |             
      Ulcer                                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                         +|             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcapsular, Hyperplasia             | 2  2  2  2  2  2  2  2  2  3  3  2  2  2  2  2  2  2  2  2  2  2  2  2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 7| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Degeneration                         | 2  1  1  2  1  2  3  1  1        2  1  1  1  2  2  2  2  2  2  2  2  2   |             
      Fibrosis                             | 1  1  1  2  1  1  2  1  1        1  1  1  1  1  1  1  1  2  2  1  1  1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  M  M  M  M  M  M  +  M  M  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    1     3              2                 2           2  2  2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
      Cyst                                 |       X        X  X  X           X        X  X  X              X         |             
      Inflammation, Chronic                |                                                 3                        |             
      Inflammation, Suppurative            |                                                                          |             
      Capsule, Fibrosis                    |                                     3                                    |             
      Capsule, Inflammation, Chronic       |                                              2                           |             
      Capsule, Mineralization              |                                              2                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 2  2     3  2  3           2              2  3  2  2     2  2  2     2   |             
      Endometrium, Inflammation,           |                                                                          |             
          Suppurative                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 3  2  3  3  2  4  2  2  1  3  3  2  1     2  2  2  3  2  2  2  2  1  1  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           4                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                           4           4     3            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                3  3                                                      |             
      Hyperplasia, Lymphoid                |             4                             4                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 7| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  +  M  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hair Follicle, Atrophy               |                   3              3                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cranium, Fibrous Osteodystrophy      |                                                    X                     |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypothalamus, Atrophy                |                                                 2                        |             
      Thalamus, Mineralization             |                                  2                                      2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           4                              |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Histiocyte                       |                2                                                         |             
      Inflammation, Chronic, Multifocal    |             2  2     2  2        1  2     2  2     1  2  2  2  1     2   |             
      Leukocytosis                         |                                                                          |             
      Alveolus, Granuloma                  |                                                          1               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                  2                                       |             
      Thrombosis                           |                                  2                                       |             
      Glands, Hyperplasia                  | 3  4  3  4  4  3  4  4  3  3  3  4  4  4  4  4  4  4  4  4  3  3  3  4  3|             
      Mucosa, Inflammation, Suppurative    | 2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  3  2  1  2  1  1  1  1  1|             
      Olfactory Epithelium, Metaplasia     | 3  3  3  3  3  3  3  3  3  2  3  3  3  3  3  3  2  3  3  3  2  3  3  3  3|             
      Respiratory Epithelium, Dysplasia    |             1                                                            |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Basal Cell                      |             3     1                                2                     |             
      Respiratory Epithelium, Hyperplasia  | 1  2  2  2  2  2  2  2  2  2  1  2  2  3  2  2  3  2  2  2  1     1  2  2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                                  2  2     2  2     3                     |             
      Respiratory Epithelium, Regeneration | 1  2  2  1  1  2  2  2  2  2  1  2  3  3  3  2  3     2  2  2  2  3  2  2|             
      Submucosa, Angiectasis, Focal        |                                  3        3                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Focal, Squamous          |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| 2| 3| 3| 2| 3| 3| 3| 3| 3| 8| 3| 3|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 7| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                       +                             +            |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       4                  |             
      Inflammation, Chronic                | 1                 2     1  1     2  2     2  2           1  1  2         |             
      Metaplasia, Focal, Osseous           |             2     2                                                      |             
      Regeneration                         |                                                                          |             
      Renal Tubule, Regeneration           |                1     1        1                 1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |             4                             4           4                  |             
      Inflammation, Chronic                | 2                                            2              2            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|            |
                                           | 0| 0| 2| 0| 0| 0| 0| 3| 0| 0| 9| 0| 0| 0| 7| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  A  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  42        |
      Inflammation, Chronic                |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                            2     4                                       |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                4                                      2                  |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Focal Cellular Change                |                                  1                                       |      1  1.0|
      Inflammation, Chronic, Multifocal    |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +           +     +                                      +              +|   8        |
      Hyperplasia, Lymphoid                |             4     4                                                      |      2  4.0|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                            3                                             |      1  3.0|
      Cyst                                 |                            X                                             |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                                                4         |      2  4.0|
      Inflammation, Chronic, Multifocal    |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       |                                                                          |      2  3.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Ulcer                                |                                  2                                       |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Atrophy                              |                               2                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|            |
                                           | 0| 0| 2| 0| 0| 0| 0| 3| 0| 0| 9| 0| 0| 0| 7| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +  +  +|  48        |
      Subcapsular, Hyperplasia             | 2  2  2  2  2  2  2     3  3  2  2  2     2  2  2     2  2  2  2  2  2  2|     46  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +  +  +|  48        |
      Accessory Adrenal Cortical Nodule    |          X                                                               |      1     |
      Degeneration                         | 2  1  1  2  2  2        2  2  2  2  2     2  2  2     1  1  1     2      |     40  1.7|
      Fibrosis                             | 2  1  1  1  1  1        2  2  1  2  1     2  1  2     1  1  1     1      |     40  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  I  +  +  +  I  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  M  +  +  +  +  +  +  +  M  +  +  M  M  +  M  M  M  +  +  M  +|  29        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  A  I  +  +  I  +  +  +  M  +  +  I  +  +  +  +  +  +|  45        |
      Pars Distalis, Hyperplasia           |                   2                             2                        |      9  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                                                       1                  |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 | X              X        X                    X  X  X  X     X           X|     18     |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                            4              2                              |      2  3.0|
      Capsule, Fibrosis                    |                                                                          |      1  3.0|
      Capsule, Inflammation, Chronic       |                                                                          |      1  2.0|
      Capsule, Mineralization              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Endometrium, Hyperplasia, Cystic     |    2        2  2  1     2  3  1  2     2           2  2  1  2        2  2|     29  2.0|
      Endometrium, Inflammation,           |                                                                          |            |
          Suppurative                      |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  I  +  +|  48        |
      Myelofibrosis                        | 1  2     1  3  2  1     2  1  1  1  2  3  3  2  3     3  2  2  3     1  1|     45  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|            |
                                           | 0| 0| 2| 0| 0| 0| 0| 3| 0| 0| 9| 0| 0| 0| 7| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Renal, Hyperplasia, Lymphoid         |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  M  +  +  +  M  M  +  M  +  M  M  +  +  M  +  +  +  M  +  M  +  M|  37        |
      Hyperplasia, Lymphoid                |             4  4                                   2           4         |      5  3.6|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|  40        |
      Hyperplasia, Lymphoid                |                4  4           4  4                 2                     |      8  3.6|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                3                 2                                       |      4  2.8|
      Hyperplasia, Lymphoid                |                4  4        2  4  4                 2  2        4         |     10  3.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  M  +  +|  42        |
      Hyperplasia, Lymphoid                |             4                                                            |      1  4.0|
      Inflammation, Suppurative            |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  M  +  +  M  M  +  +  M|  30        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hair Follicle, Atrophy               |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cranium, Fibrous Osteodystrophy      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypothalamus, Atrophy                |                                                                          |      1  2.0|
      Thalamus, Mineralization             |                   2                                2                     |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |             4  4  4                                            4         |      5  4.0|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Inflammation, Chronic, Multifocal    |                   1        1  2  1  1        1  2  2  2     1            |     24  1.6|
      Leukocytosis                         |                      2                                                   |      1  2.0|
      Alveolus, Granuloma                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 7| 7| 0| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 3| 0| 3| 3| 8| 3| 3| 3| 2| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|            |
                                           | 0| 0| 2| 0| 0| 0| 0| 3| 0| 0| 9| 0| 0| 0| 7| 0| 0| 0| 0| 7| 0| 0| 0| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    FEMALE                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           |                                                                          |      1  2.0|
      Glands, Hyperplasia                  | 4  3  4  3  4  3  3     3  4  1  3  3  3  3  3  3  3  3  3  3  3  3  3  3|     49  3.3|
      Mucosa, Inflammation, Suppurative    | 2  2  2  1  1  1  3  2  1  2  1  2  2  2  2  2  1  1  2  2  1  2  2  1  1|     49  1.7|
      Olfactory Epithelium, Metaplasia     | 3  3  3  2  3  3  3     3  3  1  3  3  3  3  3  3  3  3  3  3  3  3  3  3|     49  2.9|
      Respiratory Epithelium, Dysplasia    |                                     2  1                                 |      3  1.3|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Basal Cell                      |                                        1     2                 1     2   |      7  1.7|
      Respiratory Epithelium, Hyperplasia  | 2  2  2  2  1  2  2     2  3  2  2  2  2  2  2  2  1  1  2  2  2  2  2  2|     48  1.9|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |    3           2  2     3        3           2           2               |     12  2.3|
      Respiratory Epithelium, Regeneration | 2  2  3  1     2  2     2  3  3  1  3  3  2  3  2  2     2  1  2  2  2  2|     46  2.1|
      Submucosa, Angiectasis, Focal        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Metaplasia, Focal, Squamous          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                  +                       +               |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +                       +               |   5        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Inflammation, Chronic                |                            1              1  2  2  2  2           1      |     18  1.6|
      Metaplasia, Focal, Osseous           |                                                                          |      2  2.0|
      Regeneration                         |                               2                                          |      1  2.0|
      Renal Tubule, Regeneration           |                                                                      1   |      5  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hyperplasia, Lymphoid                |                4                                                         |      4  4.0|
      Inflammation, Chronic                |                                                 3  2  1                  |      6  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 0| 1| 6| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 2| 2| 2| 2| 2| 2| 2| 3| 1| 7| 2| 2| 1| 1| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  A  A  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Suppurative            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Suppurative            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Suppurative            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
      Lymphoid Tissue, Hyperplasia         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Submucosa, Amyloid Deposition        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Necrosis, Coagulative                |                            3                                             |             
      Centrilobular, Fatty Change,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Serosa, Fibrosis                     |                                                 3                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +                                                                  |             
      Inflammation, Chronic                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Diffuse                    |                                                 3                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                  1                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                          2        2      |             
      Mineralization, Focal                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Diffuse                     |                                              2                           |             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Dysplasia, Focal                     |                                                                          |             
      Necrosis, Multifocal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                 +                    +   |             
      Developmental Malformation           |                                                 X                    X   |             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 0| 1| 6| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 2| 2| 2| 2| 2| 2| 2| 3| 1| 7| 2| 2| 1| 1| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrium, Thrombosis                   |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic, Focal                   |                                                                          |             
      Valve, Inflammation, Chronic, Focal  |    1                                                                     |             
      Valve, Pigmentation, Focal           | 1                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcapsular, Hyperplasia             | 1  3  1     1  1  1  1     2  2  1  1     2  2  2  1  2  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  |                                           2                              |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  M  +  M  +  M  +  I  +  +  +  +  M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                               3  2           2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                          +  +                                          |             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                               3                                          |             
      Inflammation, Suppurative            | 3                          4                                             |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +           +  +  +  M  +|             
      Inflammation, Suppurative            |                            2                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                 4                        |             
      Hemorrhage, Diffuse                  |                                                                          |             
      Inflammation, Suppurative            |                                     3                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Bilateral, Atrophy                   |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 0| 1| 6| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 2| 2| 2| 2| 2| 2| 2| 3| 1| 7| 2| 2| 1| 1| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | M  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Mesenteric, Hyperplasia              |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  M  +  I  +  +  +  I  +  +  M  M  M  +  +  M  +  +  +  M  +  +  M|             
      Edema                                |                                                 4                        |             
      Hyperplasia, Lymphoid                |                                                 4                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  M  +  +  M  +  +  M  +  +  +  +     +  +  M  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                   1  2     2              2  1                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                            2        2                                    |             
      Capsule, Fibrosis                    |                                                 3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  M  I  M  +  M  +  I  M  M  +  +  +  +  +  M  +  M  +  +  I|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dermis, Abscess                      |                                                                          |             
      Epidermis, Necrosis, Acute           |                         4                                                |             
      Hair Follicle, Atrophy               |                3        3           2                                    |             
      Prepuce, Inflammation, Suppurative   |                            4        4                                    |             
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |             
           Acute                           |                         3                                                |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                 2                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Atrophy                    |                                                                          |             
      Thalamus, Hemorrhage, Acute, Focal   |                         2                                                |             
      Thalamus, Mineralization             | 2  1     2        1              1  1  2  1     2     2        1     1  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 1| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 0| 1| 6| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2|             
                                           | 2| 2| 2| 2| 2| 2| 2| 3| 1| 7| 2| 2| 1| 1| 2| 2| 2| 2| 2| 5| 2| 2| 2| 2| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Congestion, Diffuse                  |                      2                                                   |             
      Infiltration Cellular, Histiocyte    |                                                                1         |             
      Inflammation, Chronic, Multifocal    | 2  2        1     1                       1  1  1                 1      |             
      Alveolus, Adenomatosis, Focal        |                               2  2                                       |             
      Alveolus, Hyperplasia, Focal         |                                              2              1            |             
      Glands, Ectasia                      |    2        2  2                    2     2                              |             
      Glands, Inflammation, Suppurative    |    2                                                                     |             
      Interstitium, Inflammation, Acute    |                                     1                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   |                                     3                                    |             
      Glands, Hyperplasia                  |    1     1           1                                            1      |             
      Mucosa, Inflammation, Suppurative    |                      2                                                   |             
      Olfactory Epithelium, Metaplasia     |    1     1           1                                                   |             
      Submucosa, Angiectasis               |                            2                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   | 1  2  2  1  1     2  1     1  2  2  2  1  2  2  2  2     2     2  2     2|             
      Mediastinum, Hyperplasia, Lymphoid   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                          +               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +              +  +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Inflammation, Chronic                | 1  1  1  1  1  1  1        1  1  1        2  1  1  1        1     1      |             
      Inflammation, Suppurative            |                            2        4                                    |             
      Cortex, Metaplasia, Osseous          |                                                                      4   |             
      Renal Tubule, Dilatation, Diffuse    |                                                 2                        |             
      Renal Tubule, Regeneration           | 1  1  1     1  1  2           2  1        1        1  2     1     2  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          2                          4                                    |             
      Inflammation, Suppurative            |                            3                                             |             
      Transitional Epithelium, Necrosis    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 1| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 0| 3|            |
                                           | 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 5| 2| 2| 1| 2| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  45        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  47        |
      Inflammation, Suppurative            | 3                                                                        |      1  3.0|
      Parasite Metazoan                    |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  47        |
      Inflammation, Suppurative            | 3  3                                                                     |      2  3.0|
      Parasite Metazoan                    |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  45        |
      Lymphoid Tissue, Hyperplasia         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  45        |
      Hyperplasia, Lymphoid                |                                                 2                        |      1  2.0|
      Submucosa, Amyloid Deposition        |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Developmental Malformation           |                            X                                             |      1     |
      Focal Cellular Change                |                                  X                       X               |      2     |
      Necrosis, Coagulative                |                                                                          |      1  3.0|
      Centrilobular, Fatty Change,         |                                                                          |            |
          Multifocal                       |                2                                                         |      1  2.0|
      Serosa, Fibrosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                                                |   2        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Fibrosis, Diffuse                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                  2                                       |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperkeratosis                       |                                     2                                    |      3  2.0|
      Mineralization, Focal                |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy, Diffuse                     |                                                                          |      1  2.0|
      Atrophy                              |                                        3                                 |      1  3.0|
      Cyst                                 |                                                    X                     |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 1| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 0| 3|            |
                                           | 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 5| 2| 2| 1| 2| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Dysplasia, Focal                     |                                           2                              |      1  2.0|
      Necrosis, Multifocal                 |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                      +   |   3        |
      Developmental Malformation           |                                                                          |      2     |
      Inflammation, Chronic, Focal         |                                                                      2   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrium, Thrombosis                   |                                                       X                  |      1     |
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic, Focal                   |                               2                                          |      1  2.0|
      Valve, Inflammation, Chronic, Focal  |                                                                          |      1  1.0|
      Valve, Pigmentation, Focal           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Subcapsular, Hyperplasia             | 1  1  1  1  2  1  1  2  2  1  2  2  2  1  1  4  1  2  2  2  1     3  1  1|     46  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Degeneration, Focal                  |       2                                                                  |      2  2.0|
      Hypertrophy, Focal                   |       4                                                                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  I  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  A  +  I  +|  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  +  M  M  +  M  +  M  M  +  +  M  M  M  M  +  +  M  M  +  M  M|  25        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |             1                                                            |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                       +                  |   1        |
      Inflammation, Necrotizing            |                                                       4                  |      1  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +                       +                    +     +                  |   8        |
      Cyst                                 |                            X                    X                        |      2     |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            | 4  4                                                  4                  |      5  3.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 1| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 0| 3|            |
                                           | 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 5| 2| 2| 1| 2| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  45        |
      Inflammation, Suppurative            |                                                       3                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | M  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Dilatation                           |                                                                          |      1  4.0|
      Hemorrhage, Diffuse                  |                                                                3         |      1  3.0|
      Inflammation, Suppurative            |                                                       3                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Mineralization                       |          2                             1                                 |      2  1.5|
      Bilateral, Atrophy                   |             2                       3                                    |      2  2.5|
      Interstitial Cell, Hyperplasia       |       2                                                                  |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  A  +  +  +|  43        |
      Mesenteric, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  M  +  +  +  +  +  M  M  M  M  +  +  +  M  +  +  M  +  M  +  M  +|  29        |
      Edema                                |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  M  +  +  M  M  +  M  +  +  +  +  +  +  +  +  M  M  A  M  +  +|  34        |
      Hyperplasia, Lymphoid                |                                                                         4|      1  4.0|
      Infiltration Cellular, Histiocyte    |    2              2                                                      |      7  1.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                                                       2                  |      3  2.0|
      Capsule, Fibrosis                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  +  M  +  +  +  +  M  +  M  +  +  +  M  +  +  M  +  +  M|  30        |
      Cyst                                 |                         X  X     X                                       |      3     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M|   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Dermis, Abscess                      |                                     2                                    |      1  2.0|
      Epidermis, Necrosis, Acute           |                                                                          |      1  4.0|
      Hair Follicle, Atrophy               |                                                                          |      3  2.7|
      Prepuce, Inflammation, Suppurative   |                                     3                                    |      3  3.7|
      Subcutaneous Tissue, Hemorrhage,     |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 1| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 0| 3|            |
                                           | 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 5| 2| 2| 1| 2| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Suppurative                     | 2  2                                                                     |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Thalamus, Atrophy                    |                                     4                                    |      1  4.0|
      Thalamus, Hemorrhage, Acute, Focal   |                                                                          |      1  2.0|
      Thalamus, Mineralization             | 2     2  2        2  2  2     2  2        2  1        1  2  1  1  2     2|     29  1.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion, Diffuse                  |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                               1                                          |      2  1.0|
      Inflammation, Chronic, Multifocal    |                2  1  2  1        2           2     1     1  1            |     17  1.4|
      Alveolus, Adenomatosis, Focal        |                                                                          |      2  2.0|
      Alveolus, Hyperplasia, Focal         |                                                                          |      2  1.5|
      Glands, Ectasia                      |                                  3  2              2                     |      8  2.1|
      Glands, Inflammation, Suppurative    |                                                                          |      1  2.0|
      Interstitium, Inflammation, Acute    |                                                       3              1   |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Dilatation                   |                                                                          |      1  3.0|
      Glands, Hyperplasia                  |                1  1                    1                    2            |      8  1.1|
      Mucosa, Inflammation, Suppurative    |                                                             2            |      2  2.0|
      Olfactory Epithelium, Metaplasia     |                                     1                                    |      4  1.0|
      Submucosa, Angiectasis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Dilatation                   |    2  2  1  2  1  1  1  2  2  2  2  2  2  1  1  2  2     2  2  2  2      |     41  1.7|
      Mediastinum, Hyperplasia, Lymphoid   |                                                                         4|      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +              +                                 |   5        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7|            |
                             DAY ON TEST   | 1| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 1| 3| 3| 5| 3| 0| 3|            |
                                           | 4| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2| 9| 5| 2| 2| 1| 2| 8| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    CONTROL                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |    1  2  2     2  1  1  1  1  1  2  1  2  1  2  1  1  1  1  1  1  1  2  1|     39  1.2|
      Inflammation, Suppurative            | 3                                                     2                  |      4  2.8|
      Cortex, Metaplasia, Osseous          |                                                                          |      1  4.0|
      Renal Tubule, Dilatation, Diffuse    |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |    1  1  1  1  2  1  2  1           1  1  1  1  1     1     1     1  1  1|     32  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  49        |
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Inflammation, Suppurative            | 4  4                                                  4                  |      4  3.8|
      Transitional Epithelium, Necrosis    | 4                                                                        |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 7| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7|             
                                           | 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +        +              +        +                                +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A        +              +        M                                A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +        +              +        +                                A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       M        +              +        +                                A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +        +              +        +                                A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +        +              +        +                                A|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +        +              +        +                                A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +        +              +        +                                A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +        +              +        +                                A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +        +              +        +                                A|             
                                            __________________________________________________________________________|             
   Liver                                   |       +        +        +     +        +  +        +  +        +        +|             
      Basophilic Focus                     |                                                                3         |             
      Cyst, Multiple                       |                                                                          |             
      Inflammation, Chronic, Multifocal    |                1                                                         |             
      Proliferation Connective Tissue      |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +        +              +        +              +                 +|             
      Cyst                                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       M        +              +        +                                +|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +        +           +  +     +  +                       +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +        +              +     +  +                       +        +|             
      Hyperkeratosis                       |                                     2                                    |             
      Hyperplasia, Squamous                |                                                                3         |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +        +           +  +     +  +                       +        +|             
      Ulcer, Multiple                      |                                        2                                 |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                     +                                    |             
      Abscess                              |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +        +              +        +                                +|             
                                            __________________________________________________________________________|             
   Heart                                   |       +        +              +        +                                +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +        +              +        +                                +|             
      Subcapsular, Hyperplasia             |                2              2        1                                2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +        +              +        +                                +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +        +              +        +                                +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +        +              +        I                                +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       M        +              M        M                                M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +        +              +        +                                +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +        +              +        +                                M|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 7| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7|             
                                           | 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +        +              +        +                                +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                         +|             
      Inflammation, Necrotizing            |                                                                         2|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +     +           +  +                          +         |             
      Cyst                                 |                      X                                                   |             
      Inflammation, Chronic                |                                                                2         |             
      Inflammation, Suppurative            |                                  2  2                                    |             
                                            __________________________________________________________________________|             
   Prostate                                |       +        +              +        +                                +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +        +                       +                       +        +|             
      Dilatation                           |                                                                3         |             
                                            __________________________________________________________________________|             
   Testes                                  |       +        +              +        +                                +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |       +        +              +        +                                +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +        +              +        +                                +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +        +              +        M                 +        +     +|             
      Mesenteric, Hemorrhage, Acute        |                                                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   |       +        +              +        M                                M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +        +              I        M                                +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +        +           +  +     +  +              +  +              A|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |       M        M              M        +                                M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       M        M              M        M                                M|             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +     +              +  +     +                       +        +|             
      Hair Follicle, Atrophy               |          3                       3                             2         |             
      Prepuce, Ulcer                       |                2                                                         |             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
      Subcutaneous Tissue, Edema           |       2                                                                  |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                2                                                         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +        +              +        +                                +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +        +              +        +                                +|             
      Thalamus, Mineralization             |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 2| 2| 7| 2| 2| 3| 2| 2| 2| 2| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7|             
                                           | 9| 9| 0| 9| 9| 3| 9| 9| 9| 9| 2| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    5 PPM                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  |       +        +              +        +                                +|             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +        +  +  +        +  +  +  +                       +        +|             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic, Multifocal    |                   2                                                     2|             
      Alveolus, Adenomatosis, Focal        |                   1                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Hyperplasia                  | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2|             
      Mucosa, Inflammation, Suppurative    | 2  2  2  2  1     1  1  1  1  2  1  1  1  2  2  2  1  2  2  2  1  1  1  2|             
      Olfactory Epithelium, Metaplasia     | 3  3  2  2  3  1  3  3  2  3  1  3  2  2  3  3  3  1  3  3  2  3  3  3  2|             
      Respiratory Epithelium, Dysplasia    |                                                                          |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Basal Cell                      |                                                                          |             
      Respiratory Epithelium, Hyperplasia  | 1        2     2     2     1  2  1  2  2  2  2  1     1  1     1         |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    1              1                                            1         |             
      Respiratory Epithelium, Regeneration | 2  1  1  2  2  2  1  2  2  1  3  2  1  1  2  2  2  1  1     2  2  1     1|             
      Submucosa, Angiectasis               |                                                          3               |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +        +              +        +                                M|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +        +              +        +                                +|             
      Inflammation, Chronic                |                                        2                                 |             
      Inflammation, Suppurative            |                                                                         4|             
      Capsule, Fibrosis                    |                                                                          |             
      Cortex, Cyst                         |                                                                          |             
      Medulla, Cyst                        |                                        2                                 |             
      Renal Tubule, Regeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +        +              +        +                                +|             
      Calculus Micro Observation Only      |                               X                                          |             
      Inflammation, Suppurative            |                               3                                          |             
      Transitional Epithelium, Hyperplasia |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 5| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 7|            |
                                           | 4| 9| 2| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +     +              +                                         +  +|  11        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | M     +     M              M                                         +  M|   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +     +              +                                         +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M     +     +              M                                         M  M|   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +     +              +                                         +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +     +              +                                         +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +     +        +     +                       +                 +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +     +              +                                         +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +     +              +                       +                 +  +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +     +        +     +                       +                 +  +|  13        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +  +  +  +           +        +                                +  +|  19        |
      Basophilic Focus                     |                                                                          |      1  3.0|
      Cyst, Multiple                       |                            X                                             |      1     |
      Inflammation, Chronic, Multifocal    |                                                                          |      1  1.0|
      Proliferation Connective Tissue      |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +     +              +                                         +  +|  12        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +     +              +                                         +  +|  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +     +              +           +                       +     +  +|  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +     +              +           +                       +     +  +|  15        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
      Ulcer                                |                                        3                       2         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +     +              +           +                             +  +|  15        |
      Ulcer, Multiple                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                          +     +         |   3        |
      Abscess                              |                                                          2     2         |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +     +     +              +                                         +  +|  11        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +     +              +                                         +  +|  11        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +     +              +                                         +  +|  11        |
      Subcapsular, Hyperplasia             | 1     2     1              1                                         1  2|     10  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +     +              +                                         +  +|  11        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +     +              +                                         I  +|  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +     +              +                                         +  +|  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M     M     M              M                                         M  M|   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 5| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 7|            |
                                           | 4| 9| 2| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M     +     M              +                                         +  +|   9        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +     +              +                                         +  +|  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | M     +     +              +                                         +  +|  10        |
                                            __________________________________________________________________________|____________|
   Penis                                   |       +                                                                  |   2        |
      Inflammation, Necrotizing            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +                 +              +                          +      |   9        |
      Cyst                                 |                         X              X                          X      |      4     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |       2                                                                  |      3  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +     +              +                                         +  +|  11        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +     +              +                                            +|  10        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +     +              +                                         +  +|  11        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +     +     +              +                                         +  +|  11        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +     +              +                                         +  +|  11        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +        +     +                          +     +        +  +|  15        |
      Mesenteric, Hemorrhage, Acute        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M     +     +              M                          +              +  M|   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     M     +              +                          +     +        M  +|   9        |
      Hyperplasia, Lymphoid                |                                                             4            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +     M  +           +              +           +              +  +|  16        |
      Atrophy                              |                2                                                         |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                      2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M     +     M              +                                         +  M|   4        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M     M     M              M                                         M  M|            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +              +           +                       +     +  +|  17        |
      Hair Follicle, Atrophy               |          2                                                     2         |      5  2.4|
      Prepuce, Ulcer                       |       2                                                                 2|      3  2.0|
      Sebaceous Gland, Hyperplasia         |                                        3                                 |      1  3.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 5| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 7|            |
                                           | 4| 9| 2| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +     +              +                                         +  +|  11        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +     +              +                                         +  +|  11        |
      Thalamus, Mineralization             |                            2                                            2|      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +     +              +                                         +  +|  11        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +     +              +              +           +              +  +|  19        |
      Infiltration Cellular, Histiocyte    |             4                                                            |      1  4.0|
      Inflammation, Chronic, Multifocal    |                            1                                             |      3  1.7|
      Alveolus, Adenomatosis, Focal        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Hyperplasia                  |    2  2  2  2  2  2  2  2  2  2  2        2  2  2  2  2  2  2  2  2  2  2|     47  2.0|
      Mucosa, Inflammation, Suppurative    |    1  2  1  2  2  1  1  1  2  1  1  1  3  2  2  1  1  2  3  1  1  2  2  1|     48  1.5|
      Olfactory Epithelium, Metaplasia     |    2  3  2  3  3  3  3  2  3  3  2  3  3  3  3  1  3  3  3  3  3  3  3  2|     49  2.6|
      Respiratory Epithelium, Dysplasia    |                         3                                                |      1  3.0|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Basal Cell                      |                         4                                                |      1  4.0|
      Respiratory Epithelium, Hyperplasia  |       2     2              2           2           2  1  1  1        2  1|     25  1.6|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |                      2                                                   |      4  1.3|
      Respiratory Epithelium, Regeneration |    1  2  3  3  2  1  2  2  2     2  2  2  2  2  1  1  2  2  2  2  1  3  2|     46  1.8|
      Submucosa, Angiectasis               |                                        3                                 |      2  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +     +              +                                         +  +|  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +                                 |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +           +  +  +                       +        +     +  +|  15        |
      Inflammation, Chronic                |       1                 1  1                                             |      4  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5|            |
                             DAY ON TEST   | 5| 2| 2| 2| 6| 2| 2| 2| 2| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| 7|            |
                                           | 4| 9| 2| 9| 7| 9| 9| 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    5 PPM                                  | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Capsule, Fibrosis                    |                                                                2         |      1  2.0|
      Cortex, Cyst                         |                         X     X                                          |      2     |
      Medulla, Cyst                        |                                                                          |      1  2.0|
      Renal Tubule, Regeneration           |       1     1                                                        2   |      3  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +     +              +                                         +  +|  11        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                            X  X                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic, Multifocal    |                               2                                          |             
      Necrosis, Coagulative                | 4                                                                        |             
      Bile Duct, Cyst                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Ulcer                                |                2                                                         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Chronic                         |                                                             4            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Acute,     |                                                                          |             
           Focal                           |                                                                          |             
      Myocardium, Inflammation, Chronic    | 2                                      1                                 |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcapsular, Hyperplasia             | 1  1  1  1  2  1  1  1  2  1  1  1  1  1     2  1  1  1  2  1  1  1  1  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia, Focal                   |                                                                         2|             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  +  +  M  M  +  +  +  +  +  +  +  M  M  +  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |          +                       +  +                 +                  |             
      Cyst                                 |          X                       X  X                 X                  |             
      Cyst, Multiple                       |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  +  +  +  M  +  +  +  +  M  +  M  +  +  M  +  +  +  +  M  M  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  M  M  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 2                                      2                                 |             
      Hyperplasia, Lymphoid                |             2                                2        3                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  M  +  +  I  +  M  M  M  +  +  +  +  +  +  +  M  M  +  +|             
      Mediastinum, Inflammation, Chronic   |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 9| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 0| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebrum, Mineralization             |                                                                          |             
      Hypothalamus, Atrophy                |                      4                                                   |             
      Thalamus, Mineralization             |       2                                2  2        1     1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                                                          |             
      Infiltration Cellular, Histiocyte    |    2                          3                                          |             
      Inflammation, Chronic, Multifocal    |             1  2     2        1        2        1     1        1     2   |             
      Inflammation, Suppurative            | 3                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Hyperplasia                  | 3  2  3  3  3  4  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3|             
      Mucosa, Inflammation, Suppurative    | 3  2  2  3     2     3  2  2  2  3  2  2  1  2  2  2  1  2  2  1  2  1  1|             
      Olfactory Epithelium, Metaplasia     | 3  3  3  2  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  3|             
      Respiratory Epithelium, Dysplasia,   |                                                                          |             
           Focal                           | 2                                                                        |             
      Respiratory Epithelium, Dysplasia    |                               2                                          |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Basal Cell                      | 2                             2                                   2      |             
      Respiratory Epithelium, Hyperplasia  | 3        3  2  2  2  2                 2     2  2  2  2  1  2  1  2  2  2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    2        2              1              2     2        2               |             
      Respiratory Epithelium, Regeneration | 2  2     2  2  2  3  2  1  1     2  2  1  2  3  2  2  2  2  3  2  2  2  3|             
      Submucosa, Angiectasis               |          2              2  2        2  3                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Epithelium, Metaplasia, Squamous     | 2                                                                        |             
      Glands, Dilatation                   |       1  1              1     1  1     1  1  1  1     1  1        1     1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       1        2     2  1  1  1  1     2  1  1     1     1  1  1  2     1|             
      Renal Tubule, Regeneration           |                         2  1     2           2     1  2  2  2  1  2  1  2|             
      Renal Tubule, Regeneration,          |                                                                          |             
          Multifocal                       |                                        2                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Multifocal    |                                              2  1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  I  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Focal Cellular Change                |                                                                          |      2     |
      Inflammation, Acute, Focal           |             1                                                            |      1  1.0|
      Inflammation, Chronic, Multifocal    |                                                                   1      |      2  1.5|
      Necrosis, Coagulative                |                                                                          |      1  4.0|
      Bile Duct, Cyst                      | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                |                                                    2        2  1         |      4  1.8|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperkeratosis                       | 2                                                                        |      1  2.0|
      Ulcer                                |                                                          3               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |             +                             +                              |   3        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |             3                             3                              |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Myocardium, Inflammation, Acute,     |                                                                          |            |
           Focal                           |                   2                                                      |      1  2.0|
      Myocardium, Inflammation, Chronic    |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Subcapsular, Hyperplasia             | 1  1  2  3  1  2  2  2  1  1  1  2  2  2  2  1  2  3  2  1  1  1  1  2  1|     49  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |       X                                                                  |      1     |
      Hyperplasia, Focal                   |                                        2                                 |      2  2.0|
      Hypertrophy, Focal                   |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  I  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  M  M  M  M  +  M  M  M  +  M  M  M  M  M  +  M  M  M  +  +  M|  23        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  49        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         |             2                                                            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                               +           +  +           +               |   8        |
      Cyst                                 |                                              1                           |      5  1.0|
      Cyst, Multiple                       |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  M  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  M  +  +  M  M  +  +  +  M  M  M  +  +  M  M  M  +  M  M  +  +  +  +  +|  29        |
      Hyperplasia, Lymphoid                |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  +  +  +  M  M  +  M  M  +  M  +  +  +  M  +  +  +  +  M  +  +|  33        |
      Hyperplasia, Lymphoid                |                            2                                             |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Atrophy                              |                   2     2                                                |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  M  +  +  M  M  M  +  +  M  +  M  M  +  +  M  +  M  M  +|  31        |
      Mediastinum, Inflammation, Chronic   |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebrum, Mineralization             |                         2                                                |      1  2.0|
      Hypothalamus, Atrophy                |                                                                          |      1  4.0|
      Thalamus, Mineralization             |    1                          2                                         1|      8  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Granuloma                            |                                                       1                  |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  2.5|
      Inflammation, Chronic, Multifocal    |       1     2  2           1        1  1  1     1              1  2  1  1|     21  1.3|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Glands, Hyperplasia                  | 3  3  3  3     3  3  3  3  4  3  3  3  3  3     3  3  3  3  3  3  3  3  3|     48  3.0|
      Mucosa, Inflammation, Suppurative    | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     1  2  2  2  2  2  2  2  2|     47  2.0|
      Olfactory Epithelium, Metaplasia     | 3  3  3  3  3  3  3  3  3  3  3  3  3  3  3  2  3  3  3  3  3  3  3  3  3|     50  3.0|
      Respiratory Epithelium, Dysplasia,   |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Respiratory Epithelium, Dysplasia    |                                     1                       1            |      3  1.3|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
           Basal Cell                      |                                     1     3                 2     3      |      7  2.1|
      Respiratory Epithelium, Hyperplasia  | 2  2  2  2  2     2  2  2  2  2  2  2  2  2     2  2  2  2  2  2  2  2  2|     40  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 2           2                                                            |      8  1.9|
      Respiratory Epithelium, Regeneration |    2  2  2     2  2  2  2  2  2  3  3  2  2  3  2  2  2  2  2  2  2  3  2|     46  2.1|
      Submucosa, Angiectasis               |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Epithelium, Metaplasia, Squamous     |                                                                          |      1  2.0|
      Glands, Dilatation                   | 1  1     1  2  1        1  1  1                 1     2  2  2        1  1|     27  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05080-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                        ALLYL GLYCIDYL ETHER                                   Date: 04/30/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 14:14:11  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3|            |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 9| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|      A     |
    10 PPM                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|      L     |
    MALE                                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic                | 1  1  1  1     1     1     1  1     2              1     1  1  1        2|     30  1.2|
      Renal Tubule, Regeneration           |    2  1  2  1  1        2  2  1     2  2  2     1  1  1  2  1  2  1  2  1|     32  1.6|
      Renal Tubule, Regeneration,          |                                                                          |            |
          Multifocal                       | 2                                                                        |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic, Multifocal    |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
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