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TDMS Study 05090-02 Pathology Tables

NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97
Route: GAVAGE                                                                                                     Time: 13:10:57




       Facility:  American Biogenics Corp.

       Chemical CAS #:  91-64-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































Note:  Animals arranged according to CID number

                                                              Page   1

NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 6| 9| 5| 3| 7| 3| 3| 6| 3| 3| 1| 0| 3| 5| 6| 5| 6| 2| 3| 5| 3| 3|             
                                           | 4| 4| 9| 7| 4| 6| 4| 3| 3| 4| 0| 4| 3| 4| 8| 4| 7| 0| 5| 0| 9| 4| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  M  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  M     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +     +  M  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  A  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
      Hepatocellular Adenoma               |    X        X     X                                                     X|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |       X                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +     +                          +  +         |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
      Lymphoma Malignant                   |       X                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Leiomyosarcoma, Metastatic           |                      X                                                   |             
      Lymphoma Malignant                   |                                                                   X      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
      Lymphoma Malignant                   |       X                                                                  |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  M  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Lymphoma Malignant                   |       X                                                           X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
      Lymphoma Malignant                   |       X                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
      Pheochromocytoma Benign              |                            X                                         X   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
      Adenoma                              |                                                                         X|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  I  M  +  +     M  M  M  M  +  +     +     +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +     +  +  +  M  +  +     +     +  M  A  +  +|             
      Pars Distalis, Adenoma               |          X                                   X                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +     I  +  +  +  +  +     +     +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 6| 9| 5| 3| 7| 3| 3| 6| 3| 3| 1| 0| 3| 5| 6| 5| 6| 2| 3| 5| 3| 3|             
                                           | 4| 4| 9| 7| 4| 6| 4| 3| 3| 4| 0| 4| 3| 4| 8| 4| 7| 0| 5| 0| 9| 4| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Follicular Cell, Carcinoma|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Cystadenoma                          |                                                                          |             
      Lymphoma Malignant                   |       X                                                           X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Hemangioma                           |                                                                          |             
      Leiomyosarcoma                       |                                                                          |             
      Lymphoma Malignant                   |       X                                                           X      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Lymphoma Malignant                   |       X                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Pancreatic, Lymphoma Malignant       |                                                                         X|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Lymphoma Malignant                   |       X                                                           X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  M  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |       X                                                                 X|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Lymphoma Malignant                   |       X                                                           X      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +     +  +  +  +  +  +     +     +  M  +  +  +|             
      Lymphoma Malignant                   |       X                                                           X     X|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Fibroma                              |                                        X                                 |             
      Fibrosarcoma                         |                                                                         X|             
      Lymphoma Malignant                   |                                                                   X      |             
      Subcutaneous Tissue, Leiomyosarcoma  |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                       +                           |             
      Leiomyosarcoma, Metastatic           |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 3| 6| 4| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7| 5| 4| 4| 4| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 8| 6| 9| 5| 3| 7| 3| 3| 6| 3| 3| 1| 0| 3| 5| 6| 5| 6| 2| 3| 5| 3| 3|             
                                           | 4| 4| 9| 7| 4| 6| 4| 3| 3| 4| 0| 4| 3| 4| 8| 4| 7| 0| 5| 0| 9| 4| 0| 4| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +     +     +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                           X                              |             
      Lymphoma Malignant                   |       X                                                           X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Lymphoma Malignant                   |       X                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                   +                                                      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
      Adenoma                              |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  A  +  +|             
      Lymphoma Malignant                   |       X                                                                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +     +  +  +  +  +  +     +     +  +  A  M  +|             
      Lymphoma Malignant                   |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +     +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |       X                                                           X     X|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 7| 4| 7| 7| 4| 4| 0| 1| 4| 7| 7| 7| 7| 5| 4| 4| 6| 7| 4| 4| 4| 4|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 3| 2| 6| 6| 0| 5| 6| 3| 3| 3| 3| 8| 6| 5| 2| 3| 6| 5| 5| 5|             
                                           | 0| 2| 5| 3| 4| 2| 9| 0| 0| 4| 9| 0| 3| 2| 3| 4| 9| 0| 6| 3| 2| 0| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  M  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    A  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    A  +  +  M  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    A  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    A  +  +  M  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    A  +  +  I  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    A  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Hepatocellular Adenoma               |                   X                          X                    X      |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Leiomyosarcoma, Metastatic           |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Squamous Cell Papilloma              |                                                 X                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  M  M  +  +        M  M     +  +  M  +  M     +  M  +     M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Pars Distalis, Adenoma               |                                                          X               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +        M  +     +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 7| 4| 7| 7| 4| 4| 0| 1| 4| 7| 7| 7| 7| 5| 4| 4| 6| 7| 4| 4| 4| 4|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 3| 2| 6| 6| 0| 5| 6| 3| 3| 3| 3| 8| 6| 5| 2| 3| 6| 5| 5| 5|             
                                           | 0| 2| 5| 3| 4| 2| 9| 0| 0| 4| 9| 0| 3| 2| 3| 4| 9| 0| 6| 3| 2| 0| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Bilateral, Follicular Cell, Carcinoma|                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Cystadenoma                          |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Hemangioma                           |                                                             X            |             
      Leiomyosarcoma                       |             X                                                            |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    M  +  +  +  +  +        +  M     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  M  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +        +  +     +  +  +  +  I     +  +  +     +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +  M        M  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Fibroma                              |                                                                          |             
      Fibrosarcoma                         |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Subcutaneous Tissue, Leiomyosarcoma  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Leiomyosarcoma, Metastatic           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 0| 4| 7| 4| 7| 7| 4| 4| 0| 1| 4| 7| 7| 7| 7| 5| 4| 4| 6| 7| 4| 4| 4| 4|             
                             DAY ON TEST   | 6| 0| 5| 3| 7| 3| 2| 6| 6| 0| 5| 6| 3| 3| 3| 3| 8| 6| 5| 2| 3| 6| 5| 5| 5|             
                                           | 0| 2| 5| 3| 4| 2| 9| 0| 0| 4| 9| 0| 3| 2| 3| 4| 9| 0| 6| 3| 2| 0| 5| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    A  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    A  +  +  +  +  +        A  +     +  +  +  +  +     +  +  +     +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +  +  +        +  +     +  +  +  +  +     +  +  +     +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 0| 7| 7| 7| 7| 0| 7| 6| 0| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 2| 3| 2| 8| 3| 6| 1| 2| 2| 3| 2| 0| 3| 8| 0| 3| 3| 5| 3| 3|              |            |
                                           | 9| 4| 9| 3| 2| 0| 2| 9| 9| 2| 9| 2| 2| 3| 4| 2| 4| 6| 2| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +     +  +  +  +  +  A  +  A  A  +  +  +  M  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  A  +     A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  A  +     A  +  +  +  +  A  +  A  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  A  +     A  +  +  +  +  +  +  A  +  +  +  +  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  M     A  +  +  +  M  +  +  A  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  A  +     A  +  +  +  +  +  +  A  A  +  +  +  +  +               |  52        |
      Lymphoma Malignant Histiocytic       |                                              X                           |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  A  +     A  +  +  +  +  +  +  A  A  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +     A  +  +  +  +  A  +  M  M  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  A  +     A  +  +  +  +  A  +  A  A     +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Hepatocellular Adenoma               |                         X     X                                          |          9 |
      Histiocytic Sarcoma                  |                                        X                                 |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                       +                                                |   7        |
      Lymphoma Malignant                   | X                                                                        |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  A  +     +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  56        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Leiomyosarcoma, Metastatic           |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  A  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  A  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +               |  56        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  A  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +               |  54        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Lymphoma Malignant                   |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  57        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  57        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +  +  M  +               |  57        |
      Pheochromocytoma Benign              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  A  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +               |  57        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   8                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 0| 7| 7| 7| 7| 0| 7| 6| 0| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 2| 3| 2| 8| 3| 6| 1| 2| 2| 3| 2| 0| 3| 8| 0| 3| 3| 5| 3| 3|              |            |
                                           | 9| 4| 9| 3| 2| 0| 2| 9| 9| 2| 9| 2| 2| 3| 4| 2| 4| 6| 2| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +     +  +  +  +  +  +  +  M  +  +  +  M  +  +               |  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  M  M  +     +  +  +  +  +  +  +  +  +  +  +  +  +  I               |  53        |
      Pars Distalis, Adenoma               | X                                                                        |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  A  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +               |  55        |
      Bilateral, Follicular Cell, Carcinoma| X                                                                        |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Cystadenoma                          |                               X                 X                        |          2 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  A  +     A  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Hemangioma                           |                                                                          |          1 |
      Leiomyosarcoma                       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  M  +     +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  57        |
      Pancreatic, Lymphoma Malignant       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +     +  +  +  +  +  +  +  A  M  +  +  +  +  +               |  55        |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +     +  +  +  +  +  +  +  A  A  +  +  +  +  +               |  53        |
      Lymphoma Malignant Histiocytic       |                                              X                           |          1 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  A  +     +  +  +  +  +  +  +  A  A  I  +  +  M  +               |  51        |
      Lymphoma Malignant                   |                                                                          |          3 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  A  +     +  +  +  +  +  M  +  +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Fibroma                              |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page   9                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 4| 0| 7| 7| 7| 7| 0| 7| 6| 0| 7| 7| 4| 7| 7|              |            |
                             DAY ON TEST   | 2| 3| 2| 8| 3| 6| 1| 2| 2| 3| 2| 0| 3| 8| 0| 3| 3| 5| 3| 3|              |            |
                                           | 9| 4| 9| 3| 2| 0| 2| 9| 9| 2| 9| 2| 2| 3| 4| 2| 4| 6| 2| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |     T      |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosarcoma                         |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Subcutaneous Tissue, Leiomyosarcoma  |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Leiomyosarcoma, Metastatic           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  57        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Alveolar/Bronchiolar Adenoma         |                                              X                           |          2 |
      Lymphoma Malignant                   |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  A  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +               |  53        |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Histiocytic Sarcoma                  |                                        X                                 |          1 |
      Lymphoma Malignant                   | X                                                                        |          4 |
      Lymphoma Malignant Histiocytic       |                                              X                           |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  10                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 6| 2| 6| 5| 3| 5| 5| 2| 3| 2| 9| 7| 3| 3| 2| 2| 3| 5| 7| 6|             
                                           | 5| 4| 3| 3| 0| 0| 2| 0| 6| 2| 6| 5| 9| 3| 9| 3| 0| 4| 3| 9| 9| 4| 6| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +     +        M        I  +  +  +  A  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  I     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +  +  +   |             
      Hemangiosarcoma                      |       X                                                                  |             
      Hepatoblastoma                       |                                                                          |             
      Hepatocellular Carcinoma             | X                                   X              X                     |             
      Hepatocellular Adenoma               |                   X                 X  X           X           X         |             
      Hepatocellular Adenoma, Multiple     |       X                                                                  |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                          X               |             
      Lymphoma Malignant                   |                                                 X                        |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +        +              +         |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Lymphoma Malignant                   |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
      Spindle Cell, Adenoma                | X                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 6| 2| 6| 5| 3| 5| 5| 2| 3| 2| 9| 7| 3| 3| 2| 2| 3| 5| 7| 6|             
                                           | 5| 4| 3| 3| 0| 0| 2| 0| 6| 2| 6| 5| 9| 3| 9| 3| 0| 4| 3| 9| 9| 4| 6| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Adenoma                              |                                                             X            |             
      Carcinoma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     +        +        +  +  +  M  +  +  M  +  +  M     M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     M        +        +  +  +  +  M  +  +  +  +  +     M   |             
      Pars Distalis, Adenoma               |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +        +  +     +  +  +  +  +  +  +  +  +  +     +   |             
      Cystadenoma                          |                                                                          |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +     +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Polyp                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |             
      Mediastinal, Histiocytic Sarcoma     |                                                                          |             
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
      Renal, Lymphoma Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Lymphoma Malignant                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +        +        +  +  +  +  A  +  +  I  +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Lymphoma Malignant                   |                                                 X                        |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 4| 7| 4| 4| 7| 4| 4| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 4| 6| 4|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 6| 2| 6| 5| 3| 5| 5| 2| 3| 2| 9| 7| 3| 3| 2| 2| 3| 5| 7| 6|             
                                           | 5| 4| 3| 3| 0| 0| 2| 0| 6| 2| 6| 5| 9| 3| 9| 3| 0| 4| 3| 9| 9| 4| 6| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +     +  +        +  +  +  +  +  +  +  +  +  +     +   |             
      Fibrosarcoma                         |                                                                      X   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Vertebra, Osteosarcoma               |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
      Meningioma Malignant                 |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |                   X                                X                 X   |             
      Lymphoma Malignant Lymphocytic       |          X                                                               |             
      Lymphoma Malignant                   |                                                 X                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +        +        +  +  +  +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +                  |             
      Adenoma                              |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +        +        +  +  +  +  A  +  +  +  +  +     +   |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M     +        +        +  M  +  +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                 X                        |             
      Lymphoma Malignant Lymphocytic       |          X                                               X     X         |             
      Lymphoma Malignant Mixed             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 6| 7| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 8| 2| 3| 3| 2| 2| 6| 5| 5| 5| 3| 3| 9| 2| 5| 3| 3| 2| 2| 3| 3| 3|             
                                           | 0| 4| 2| 3| 2| 3| 4| 9| 9| 0| 6| 5| 6| 5| 3| 5| 9| 6| 2| 3| 9| 9| 3| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  M  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  A  A  +  +  +  +              +  +  M  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  A  A  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |    X                                                                     |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Hemangiosarcoma                      |                                                                          |             
      Hepatoblastoma                       |                X                                                         |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                   X  X                    X     X     X  X     X  X      |             
      Hepatocellular Adenoma, Multiple     |       X        X                                            X        X   |             
      Histiocytic Sarcoma                  |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                X        X                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Histiocytic Sarcoma                  |                                              X                           |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pharynx                                 |             +                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +              +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +              +  +  A  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Carcinoma              |                                                 X                        |             
      Squamous Cell Papilloma              |                X                                               X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  M  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Spindle Cell, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 6| 7| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 8| 2| 3| 3| 2| 2| 6| 5| 5| 5| 3| 3| 9| 2| 5| 3| 3| 2| 2| 3| 3| 3|             
                                           | 0| 4| 2| 3| 2| 3| 4| 9| 9| 0| 6| 5| 6| 5| 3| 5| 9| 6| 2| 3| 9| 9| 3| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Adenoma                              |                                                             X            |             
      Carcinoma                            |                                                                         X|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  M  M  +  +  +  +              +  +  M  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    M  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Pars Distalis, Adenoma               |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  A  +  +  +  +  +        +     +  +  +  +     +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                          X     X         |             
      Histiocytic Sarcoma                  |                                              X                           |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  A  +  +  +  +  +        +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                              X                           |             
      Polyp                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  M  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                X                                                         |             
      Lumbar, Lymphoma Malignant Mixed     |                         X                                                |             
      Mediastinal, Histiocytic Sarcoma     |                                              X                           |             
      Mediastinal, Lymphoma Malignant Mixed|                         X                                                |             
      Pancreatic, Lymphoma Malignant Mixed |                         X                                                |             
      Renal, Lymphoma Malignant Lymphocytic|                                        X                                 |             
      Renal, Lymphoma Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  M  M  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  M  M  +  +  +  +              +  +  M  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                        X                                 |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  A  A  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             |                X        X                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  A  M  M  +  +  +              +  +  +  +     +  +  +  +  +  +  I|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                         X                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  M  +  +  +  +              +  +  +  +     +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 6| 6| 7| 7| 7| 7| 4| 4| 4| 4| 6| 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 3| 3| 8| 2| 3| 3| 2| 2| 6| 5| 5| 5| 3| 3| 9| 2| 5| 3| 3| 2| 2| 3| 3| 3|             
                                           | 0| 4| 2| 3| 2| 3| 4| 9| 9| 0| 6| 5| 6| 5| 3| 5| 9| 6| 2| 3| 9| 9| 3| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  A  +  +  +  +        +     +  +  +  +     +  +  +  +  +  +  +|             
      Fibrosarcoma                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Vertebra, Osteosarcoma               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Meningioma Malignant                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                                                          X     X         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  A  +  +  +  +  +              +  +  A  +     +  +  +  +  +  +  +|             
      Lymphoma Malignant Mixed             |                         X                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  A  +  +  +  +  +              +  +  +  +     +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                              X                           |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |    X                                   X                                 |             
      Lymphoma Malignant Mixed             |                X        X                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3|              |            |
                                           | 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |     A      |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  46        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
      Hemangiosarcoma                      |                                                                          |          1 |
      Hepatoblastoma                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          3 |
      Hepatocellular Adenoma               | X     X        X                       X                 X               |         18 |
      Hepatocellular Adenoma, Multiple     |                            X     X  X                                    |          8 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +  +                                                         |   6        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                   X     X              X                                 |          5 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  17                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3|              |            |
                                           | 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |     A      |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
      Spindle Cell, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
      Adenoma                              |                                                                          |          2 |
      Carcinoma                            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M     +  M  +  M  +  +  +  +  +  +                 M               |  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  45        |
      Pars Distalis, Adenoma               |       X                                                                  |          3 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                  +                                       |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +     +     +  +  +  +  +  +  +  +  +  +              +  +               |  52        |
      Cystadenoma                          |             X                                                            |          3 |
      Histiocytic Sarcoma                  |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +     +  +  +  +  +  +  +  +  +  +              +  +               |  55        |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Polyp                                |                                                          X               |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  49        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Lumbar, Lymphoma Malignant Mixed     |                                                                          |          1 |
      Mediastinal, Histiocytic Sarcoma     |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant Mixed|                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
      Renal, Lymphoma Malignant            |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +     +     +  +  +  +  +  +  +  +  +  M                 +               |  47        |
      Lymphoma Malignant                   |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  45        |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          3 |
      Lymphoma Malignant                   |                            X                                             |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  18                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3|              |            |
                                           | 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |     A      |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
      Lymphoma Malignant                   |                            X                                             |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  44        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  48        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  51        |
      Fibrosarcoma                         |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
      Vertebra, Osteosarcoma               |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  49        |
      Meningioma Malignant                 |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
      Alveolar/Bronchiolar Adenoma         |                                                                          |          5 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +     +  +  +  +  +  +  +  +  +  +                 +               |  47        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +     +     +  +  +  +  +  +  +  +  +  +              +  +               |  58        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  19                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 4| 4| 7|              |            |
                             DAY ON TEST   | 2| 6| 3| 6| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 5| 6| 6| 6| 5| 3|              |            |
                                           | 9| 0| 3| 0| 4| 3| 4| 2| 4| 4| 3| 9| 3| 2| 6| 0| 0| 0| 6| 3|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|              |     A      |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Histiocytic Sarcoma                  |                                                                          |          1 |
      Lymphoma Malignant                   |                            X                                             |          2 |
      Lymphoma Malignant Lymphocytic       |             X                                                            |          6 |
      Lymphoma Malignant Mixed             |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  20                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 7| 4| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 5| 2| 6| 3| 3| 3| 6| 7| 3| 5| 6| 3| 3| 2| 3| 2| 5| 3| 3| 2| 2| 5| 6| 3|             
                                           | 6| 6| 9| 0| 3| 3| 2| 0| 9| 4| 6| 0| 3| 4| 9| 3| 9| 6| 2| 3| 9| 9| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +     +  +  +     +  +        M  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +  +  +     +  +  +     +  +  +  +  +     +  +  +  +        +|             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |             X  X  X     X  X           X                 X               |             
      Hepatocellular Adenoma, Multiple     |                                     X     X           X                  |             
      Lymphoma Malignant Lymphocytic       |                            X                                   X         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +     +  +  +     +  +        +  +  +  +  I     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +     M  +  +     +  +        M  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +     +  +  +     +  +        +  M  +  +  +     +  +  M  M        +|             
      Neoplasm NOS                         |                                                                          |             
      Pars Distalis, Adenoma               |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 7| 4| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 5| 2| 6| 3| 3| 3| 6| 7| 3| 5| 6| 3| 3| 2| 3| 2| 5| 3| 3| 2| 2| 5| 6| 3|             
                                           | 6| 6| 9| 0| 3| 3| 2| 0| 9| 4| 6| 0| 3| 4| 9| 3| 9| 6| 2| 3| 9| 9| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +                                 |             
      Posterior, Fibrosarcoma              |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Cystadenoma                          |                            X        X     X                              |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +     +  +  +     +  +  +     +  +  +  +  +     +  +  +  +        +|             
      Lymphoma Malignant Mixed             |                                                                          |             
      Sarcoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                X         |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                X         |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                X         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +     +  +  +     I  +        +  +  +  +  +     +  +  +  +        +|             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant                   |                                                          X               |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +        +|             
      Hemangioma                           |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 7| 4| 6| 7| 4| 4| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 4| 4| 7|             
                             DAY ON TEST   | 5| 5| 2| 6| 3| 3| 3| 6| 7| 3| 5| 6| 3| 3| 2| 3| 2| 5| 3| 3| 2| 2| 5| 6| 3|             
                                           | 6| 6| 9| 0| 3| 3| 2| 0| 9| 4| 6| 0| 3| 4| 9| 3| 9| 6| 2| 3| 9| 9| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Alveolar/Bronchiolar Adenoma         | X                                      X                                 |             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
                                            __________________________________________________________________________|             
   Nose                                    |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
                                            __________________________________________________________________________|             
   Trachea                                 |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Adenoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Lymphoma Malignant Lymphocytic       |                                                                X         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +     +  +  +     +  +        +  +  +  +  +     +  +  +  +        +|             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +     +  +  +     +  +  +  +  +  +  +  +  +  +        +|             
      Lymphoma Malignant                   |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                            X        X                          X         |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 0| 0| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 7| 5| 7| 7| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 7| 3| 6| 0| 0| 9| 3| 3| 3| 8| 2| 6| 3| 3| 5| 8| 3| 6| 3| 3| 2| 2| 6| 3| 6|             
                                           | 2| 2| 0| 4| 3| 4| 2| 4| 3| 6| 9| 0| 4| 4| 6| 9| 4| 4| 4| 3| 9| 9| 0| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +     M  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
      Hepatocellular Carcinoma             | X                                            X                           |             
      Hepatocellular Adenoma               |                   X        X        X  X           X  X  X     X         |             
      Hepatocellular Adenoma, Multiple     | X  X                    X     X                                      X   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +        +                                                |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                X                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Squamous Cell Carcinoma              |                X                                                         |             
      Squamous Cell Papilloma              |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +     +  +  M  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +     +  +  M  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +     +  +  M  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +     +  A  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Adenoma                              |                      X                                                   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M     +  M  +  +  +  +  +  +     +  +     +  I  +  +  +  +  +     M   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +     +  +  +  M  +  +  +  M     +  +     A  +  +  +  +  +  +     +   |             
      Neoplasm NOS                         |                                                    X                     |             
      Pars Distalis, Adenoma               |                                                                X         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +     +  +  +  +  +  +  +  +     +  +     +  +  A  +  +  +  +     +   |             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 0| 0| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 7| 5| 7| 7| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 7| 3| 6| 0| 0| 9| 3| 3| 3| 8| 2| 6| 3| 3| 5| 8| 3| 6| 3| 3| 2| 2| 6| 3| 6|             
                                           | 2| 2| 0| 4| 3| 4| 2| 4| 3| 6| 9| 0| 4| 4| 6| 9| 4| 4| 4| 3| 9| 9| 0| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Posterior, Fibrosarcoma              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +     +  +  +  +  +  +  +  +     +  +     +  +  A  +  +  +  +     +   |             
      Cystadenoma                          |                                                                      X   |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +     +  +  M  +  +  +  +  +     +  +     +  +  A  +  +  +  +     +   |             
      Lymphoma Malignant Mixed             | X                                                                        |             
      Sarcoma                              |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +     +  +  +  +  +  +  +  +     +  +     A  +  +  +  +  +  +     +   |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Lumbar, Lymphoma Malignant           |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +     +  +  +  +  +  +  +  +     +  +     M  +  +  +  +  +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                X                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +     M  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +     +  +  +  +  +  +  +  +     +  +     A  +  +  +  +  +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Mixed             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +     M  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +   |             
      Hemangioma                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 4| 0| 0| 6| 7| 7| 7| 5| 7| 4| 7| 7| 4| 6| 7| 5| 7| 7| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 7| 3| 6| 0| 0| 9| 3| 3| 3| 8| 2| 6| 3| 3| 5| 8| 3| 6| 3| 3| 2| 2| 6| 3| 6|             
                                           | 2| 2| 0| 4| 3| 4| 2| 4| 3| 6| 9| 0| 4| 4| 6| 9| 4| 4| 4| 3| 9| 9| 0| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +     +  +  +  +  +  +  +  +     +  +     +  +  A  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Alveolar/Bronchiolar Adenoma         |    X           X        X                                                |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +     +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +     +   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +     +  +  +  +  +  +  +  +     +  +     +  +  A  +  +  +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +     +  +  +  +  +  +  +  +     +  +     A  +  A  +  +  +  +     +   |             
      Lymphoma Malignant Mixed             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +     +   |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                   X                                                      |             
      Lymphoma Malignant Mixed             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3|              |            |
                                           | 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |     A      |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  53        |
      Hepatocellular Carcinoma             |                                                          X               |          3 |
      Hepatocellular Adenoma               |                   X                       X  X     X  X                  |         20 |
      Hepatocellular Adenoma, Multiple     |    X                                                                     |          9 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                          +               |   3        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  51        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +     +  +  +  +     +  +     +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +     +  +  +  +     +  +     +  +  +  +  +  +  +               |  50        |
      Squamous Cell Carcinoma              |                                                                          |          1 |
      Squamous Cell Papilloma              |                                                       X                  |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +     +  +  +  +     +  +     +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +     M     M  M  +  +     M        +  +  +  +  +  +  +               |  40        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  27                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3|              |            |
                                           | 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |     A      |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  45        |
      Neoplasm NOS                         |                                                                          |          1 |
      Pars Distalis, Adenoma               |    X                    X                 X                              |          4 |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
      Follicular Cell, Adenoma             |                   X                                                      |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Posterior, Fibrosarcoma              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +     +     +  +  +  +     +     +  +  +  +  +  +  +  +               |  52        |
      Cystadenoma                          |                                                                          |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +     +  +  +  +     +  +     +  +  +  +  +  +  +               |  51        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +     +  +  +  +     +        M  +  +  +  +  +  +               |  49        |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Lumbar, Lymphoma Malignant           |                                                                          |            |
          Lymphocytic                      |    X                                                                     |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |            |
          Lymphocytic                      |                                           X                              |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Renal, Lymphoma Malignant Lymphocytic|    X                                      X                              |          3 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +     +  +  +  +     +        M  +  +  +  +  +  +               |  49        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +     +     +  +  +  +     +        M  +  +  +  +  +  +               |  48        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  48        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  28                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3|              |            |
                                           | 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |     A      |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  49        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  56        |
      Hemangioma                           |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
      Alveolar/Bronchiolar Adenoma         |    X     X                                   X                           |          8 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +     +  +  +  +     +        +  +  +  +  +  +  +               |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +     +  +  +  +     M        +  +  +  +  +  +  +               |  48        |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +     +     +  +  +  +     +  +  +  +  +  +  +  +  +  +               |  58        |
      Lymphoma Malignant                   |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  29                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 0| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 3| 3| 6| 3| 5| 3| 2| 3| 3| 5| 2| 5| 5| 7| 3| 2| 2| 3| 3| 3|              |            |
                                           | 2| 4| 0| 4| 5| 3| 9| 3| 3| 5| 9| 6| 5| 0| 2| 9| 9| 2| 3| 2|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |     T      |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|              |     A      |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |    X                                      X                              |          6 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  30                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 2| 6| 4| 4| 7| 4| 7| 5| 4| 7| 4| 4| 7| 7| 6| 2| 4| 4| 6| 7| 4| 6|             
                             DAY ON TEST   | 3| 6| 5| 5| 8| 5| 5| 0| 6| 3| 0| 6| 3| 5| 6| 3| 2| 1| 2| 6| 6| 7| 3| 6| 8|             
                                           | 2| 0| 6| 3| 4| 5| 6| 0| 0| 2| 8| 0| 2| 6| 0| 3| 9| 5| 5| 0| 0| 8| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +     +  +  +  +  +  A     +  A     +  +     +  +  +  A        +  +     A|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +  +  +  A     +  A     +  +     +  +  +  +        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +  +  +  A     +  A     +  +     +  +  +  +        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +  +  +  A     +  A     +  +     +  +  +  +        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | I     +  +  +  +  +  A     +  A     +  +     +  +  +  +        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  A  +  +  +  A     +  A     +  +     +  +  +  A        +  +     A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +  +  +  A     +  A     +  +     +  +  +  M        +  +     A|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     A|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Sarcoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic                       |                                                                          |             
      Hepatocellular Carcinoma             |                                                                          |             
      Hepatocellular Adenoma               |                            X                 X                           |             
      Hepatocellular Adenoma, Multiple     |             X                                                            |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     A|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Spindle Cell, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  M  +  +  +  +     +  M     M  M     +  +  +  M        M  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +  +  +  +     +  +     M  +     +  +  +  +        +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 2| 6| 4| 4| 7| 4| 7| 5| 4| 7| 4| 4| 7| 7| 6| 2| 4| 4| 6| 7| 4| 6|             
                             DAY ON TEST   | 3| 6| 5| 5| 8| 5| 5| 0| 6| 3| 0| 6| 3| 5| 6| 3| 2| 1| 2| 6| 6| 7| 3| 6| 8|             
                                           | 2| 0| 6| 3| 4| 5| 6| 0| 0| 2| 8| 0| 2| 6| 0| 3| 9| 5| 5| 0| 0| 8| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        M  +     A|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Cystadenoma                          |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Sarcoma Stromal                      |                                                    X              X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     +|             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +     M  +  +  +  M  +     +  M     +  +     +  +  +  +        M  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +  +  +  M     +  A     +  +     +  +  +  +        +  +     +|             
      Lymphoma Malignant Histiocytic       |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +  +  +  +     +  A     +  +     +  +  +  A        +  +     +|             
      Lymphoma Malignant Histiocytic       |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        M  +     +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     A|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 4| 4| 2| 6| 4| 4| 7| 4| 7| 5| 4| 7| 4| 4| 7| 7| 6| 2| 4| 4| 6| 7| 4| 6|             
                             DAY ON TEST   | 3| 6| 5| 5| 8| 5| 5| 0| 6| 3| 0| 6| 3| 5| 6| 3| 2| 1| 2| 6| 6| 7| 3| 6| 8|             
                                           | 2| 0| 6| 3| 4| 5| 6| 0| 0| 2| 8| 0| 2| 6| 0| 3| 9| 5| 5| 0| 0| 8| 4| 0| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Alveolar/Bronchiolar Adenoma         |                X  X  X                          X                 X     X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |             X                                                            |             
      Alveolar/Bronchiolar Carcinoma       |                            X                 X                 X         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +  +  +  +     +  +     +  +     +  +  +  A        +  +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        M  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +  +  +  +     +  A     +  +     +  +  +  +        +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +  +  +  +     +  +     M  +     +  +  +  A        +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +     +  +  +  +  +  +     +  +     +  +     +  +  +  +        +  +     +|             
      Lymphoma Malignant Histiocytic       |                                              X                           |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 4| 7| 7| 7| 4| 7| 7| 7| 0| 6| 4| 4| 2| 6| 7| 7| 7| 2| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 6| 3| 2| 3| 5| 3| 3| 1| 4| 5| 6| 2| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 3| 8| 4| 0| 2| 9| 2| 6| 2| 4| 6| 8| 5| 0| 6| 7| 7| 2| 2| 3| 8| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +  +  +  +  +  +  A  +  A     A  A  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +  +  +  +  +  +  A  A  +     +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  A  A  A     +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  A  A  +     +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  A  A  +     +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +  +  +  +  +  +  A  A  +     A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  A  A  A     A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  A  A  A     A  A  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  A  M  +     A  A  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
      Sarcoma                              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic                       |                                                                          |             
      Hepatocellular Carcinoma             |                                     X                                    |             
      Hepatocellular Adenoma               |       X                 X  X  X                       X  X     X         |             
      Hepatocellular Adenoma, Multiple     |             X                                                            |             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +  +  +  +  +  +  +  +     +  A  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +  +  +  +  +  +  A  +  A     A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  A  +  A     A  +  +  +  +  +  +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  A  A  A     A  A  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Spindle Cell, Adenoma                |             X                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic                       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 4| 7| 7| 7| 4| 7| 7| 7| 0| 6| 4| 4| 2| 6| 7| 7| 7| 2| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 6| 3| 2| 3| 5| 3| 3| 1| 4| 5| 6| 2| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 3| 8| 4| 0| 2| 9| 2| 6| 2| 4| 6| 8| 5| 0| 6| 7| 7| 2| 2| 3| 8| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cystadenoma                          |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Sarcoma Stromal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |             X                                                            |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |       X     X                                                            |             
      Renal, Lymphoma Malignant Lymphocytic|             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |             X                                                            |             
      Lymphoma Malignant Mixed             | X                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +  +  +  +  +  +  +  +  +     A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       | X     X                                                                  |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +     M  M  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |             
          Metastatic                       |                                                                          |             
      Lymphoma Malignant Lymphocytic       |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +     +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 3| 7| 4| 7| 7| 7| 4| 7| 7| 7| 0| 6| 4| 4| 2| 6| 7| 7| 7| 2| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 6| 3| 2| 3| 5| 3| 3| 1| 4| 5| 6| 2| 5| 3| 3| 3| 3| 8| 3| 3| 3| 3|             
                                           | 3| 8| 4| 0| 2| 9| 2| 6| 2| 4| 6| 8| 5| 0| 6| 7| 7| 2| 2| 3| 8| 3| 3| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X     X                                      X     X     X  X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                X                                      X                  |             
      Alveolar/Bronchiolar Carcinoma       |                   X                                                  X  X|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
      Adenoma                              |                X                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +  +  +  +  +  +  A  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  A  +  +     A  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant Lymphocytic       | X     X     X                                                            |             
      Lymphoma Malignant Mixed             | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 4| 7| 4| 4| 6| 7| 1| 6| 7| 4| 4| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 9| 1| 6| 5| 1| 2| 3| 1| 0| 5| 5| 3| 3| 3| 3| 5| 2|              |            |
                                           | 0| 3| 9| 6| 8| 0| 6| 5| 9| 9| 1| 0| 6| 5| 2| 2| 2| 3| 6| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +     +  A  M  A  +  A  +  +  +  +  +  +  +  +               |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  A  +  A  +  A  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  A  +  A  +  +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  M  +  A  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +  A  +  A  +  A  +  +  +  +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  A  +  A  +  A  +  +  +  +  +  +  +  +               |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  A  +  A  +  A  +  +  +  +  +  +  +  +               |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  A  +  A  +  A  +  +  +  +  +  +  +  +               |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Sarcoma                              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic                       |                      X                                                   |          1 |
      Hepatocellular Carcinoma             |                                                                          |          1 |
      Hepatocellular Adenoma               |                                                          X               |         10 |
      Hepatocellular Adenoma, Multiple     |                                                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          2 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                           +              +               |   4        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  A  +  A  +  +  +  +  +  +  +  +  +  +               |  54        |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  55        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  55        |
      Squamous Cell Papilloma              |    X                                                     X               |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  A  +  A  +  +  +  +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Spindle Cell, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  37                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 4| 7| 4| 4| 6| 7| 1| 6| 7| 4| 4| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 9| 1| 6| 5| 1| 2| 3| 1| 0| 5| 5| 3| 3| 3| 3| 5| 2|              |            |
                                           | 0| 3| 9| 6| 8| 0| 6| 5| 9| 9| 1| 0| 6| 5| 2| 2| 2| 3| 6| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
          Metastatic                       |                      X                                                   |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +     +  +  +  M  +  +  +  +  +  +  M  +  M  +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  57        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  M  +  +  +  +  +  +  +  +  +  +               |  56        |
      Follicular Cell, Adenoma             |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Cystadenoma                          |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Sarcoma Stromal                      |                                                                          |          2 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          2 |
      Renal, Lymphoma Malignant Lymphocytic|                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +  +  +  +  M  +  +  +  +  +  M  +               |  53        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +               |  56        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  57        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          3 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     +  +  +  +  +  I  +  +  +  I  +  I  +  M               |  51        |
      Alveolar/Bronchiolar Carcinoma,      |                                                                          |            |
          Metastatic                       |                      X                                                   |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  38                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 7| 7| 4| 7| 4| 4| 6| 7| 1| 6| 7| 4| 4| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 3| 2| 9| 1| 6| 5| 1| 2| 3| 1| 0| 5| 5| 3| 3| 3| 3| 5| 2|              |            |
                                           | 0| 3| 9| 6| 8| 0| 6| 5| 9| 9| 1| 0| 6| 5| 2| 2| 2| 3| 6| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE FEMALE                      | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |     T      |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Alveolar/Bronchiolar Adenoma         |    X  X                                   X  X  X                        |         17 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                    X     X               |          5 |
      Alveolar/Bronchiolar Carcinoma       |                      X                                                   |          7 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Adenoma                              |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  56        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                           X                              |          4 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  39                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 2| 3| 6| 2| 3| 2| 3| 3|             
                                           | 9| 0| 6| 0| 4| 0| 6| 0| 3| 4| 4| 3| 4| 4| 3| 9| 3| 9| 3| 0| 9| 4| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Adenocarcinoma                       |                                  X                                      X|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hepatocellular Carcinoma             | X              X                    X           X                    X   |             
      Hepatocellular Carcinoma, Multiple   |                                                                          |             
      Hepatocellular Adenoma               |             X        X  X              X     X                       X   |             
      Hepatocellular Adenoma, Multiple     |       X        X           X     X                 X  X                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                    +  +                    +     +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  I  M  I  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +        +                          +  +                          +  +   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 1| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 2| 5| 2| 3| 6| 2| 3| 2| 3| 3|             
                                           | 9| 0| 6| 0| 4| 0| 6| 0| 3| 4| 4| 3| 4| 4| 3| 9| 3| 9| 3| 0| 9| 4| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Interstitial Cell, Adenoma           |                               X                             X            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M     M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |       X     X                                X     X  X                  |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                 X                        |             
      Alveolar/Bronchiolar Carcinoma       |       X                                                                  |             
      Carcinoma, Metastatic                |                                                                          |             
      Hepatocellular Carcinoma, Metastatic | X                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                         +                              |             
      Adenoma                              | X                                         X                              |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                           M                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Renal Tubule, Adenoma                |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 3| 2| 2| 2| 2| 8| 6| 2| 5| 3| 2| 2| 5| 6| 6| 5| 6| 6| 2| 2| 2| 3|             
                                           | 0| 5| 6| 3| 6| 9| 9| 9| 0| 0| 9| 5| 4| 9| 9| 6| 0| 0| 5| 0| 0| 9| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  +  M  M  +     +  +  +  +  +  +        +        M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  A  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  I  I  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  A  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  A  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Adenocarcinoma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Hepatocellular Carcinoma             |                                                                   X      |             
      Hepatocellular Carcinoma, Multiple   |                X                                                         |             
      Hepatocellular Adenoma               |             X     X  X  X              X                                 |             
      Hepatocellular Adenoma, Multiple     |                                     X     X                    X     X   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +                             +  +   |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Squamous Cell Papilloma              |                                     X                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  A  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Pheochromocytoma Benign              |                X                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  I  +  +  +  +     +  M  M  M  +  +        +        +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                   +     +           +                                +   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 7| 7| 7| 7| 7| 6| 4| 7| 4| 7| 7| 7| 4| 4| 4| 4| 4| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 3| 2| 2| 2| 2| 8| 6| 2| 5| 3| 2| 2| 5| 6| 6| 5| 6| 6| 2| 2| 2| 3|             
                                           | 0| 5| 6| 3| 6| 9| 9| 9| 0| 0| 9| 5| 4| 9| 9| 6| 0| 0| 5| 0| 0| 9| 9| 9| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Interstitial Cell, Adenoma           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +     +  M  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +  +     +  +  +  M  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M  M  M  M  M  M     M  M  M  M  M  M        M        M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |             X                       X                             X      |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Carcinoma, Metastatic                |                         X                                                |             
      Hepatocellular Carcinoma, Metastatic |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                         +                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Adenoma                              |                         X                                                |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
      Renal Tubule, Adenoma                |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +  +  +  +  +     +  +  +  +  +  +        +        +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 4| 4| 5| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 6| 3| 5| 5| 4| 3| 3| 2| 3| 6| 6| 3| 3| 7| 5| 5|              |            |
                                           | 4| 5| 4| 4| 0| 4| 5| 6| 1| 4| 0| 9| 3| 0| 0| 0| 4| 0| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +        +  +  M  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +     +  +  +  A  +  M  +  +        +  +  A  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  56        |
      Adenocarcinoma                       |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +               |  60        |
      Hepatocellular Carcinoma             |                         X     X              X     X                     |         10 |
      Hepatocellular Carcinoma, Multiple   |                                                                          |          1 |
      Hepatocellular Adenoma               |       X                    X     X  X                                    |         15 |
      Hepatocellular Adenoma, Multiple     |                X                                                         |         11 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   8        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  58        |
      Squamous Cell Papilloma              |                            X                                             |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  A  +  +  +  +        +  +  A  +  +               |  56        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +     +  +  +  +  +  M  M  M        +  +  M  +  +               |  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +     +  +  +  I  +  +  +  +        M  +  M  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  58        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                       +                  |   1        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  44                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 4| 4| 5| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 6| 3| 5| 5| 4| 3| 3| 2| 3| 6| 6| 3| 3| 7| 5| 5|              |            |
                                           | 4| 5| 4| 4| 0| 4| 5| 6| 1| 4| 0| 9| 3| 0| 0| 0| 4| 0| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +  +     +           +        +           +                        |  16        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Interstitial Cell, Adenoma           |                X                                                         |          3 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +        +  +  M  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  M  +  +               |  57        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  M  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  M  +        +  +  A  +  +               |  57        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M     M  M  M  M  +  M  M  M        M  M  M  M  M               |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +               |  60        |
      Alveolar/Bronchiolar Adenoma         |          X                                   X  X  X                     |         12 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                            X                                             |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Carcinoma, Metastatic                |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  45                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 4| 7| 7| 4| 7| 4| 4| 5| 7| 7| 7| 7| 4| 4| 7| 7| 6| 4| 4|              |            |
                             DAY ON TEST   | 3| 5| 3| 3| 6| 3| 5| 5| 4| 3| 3| 2| 3| 6| 6| 3| 3| 7| 5| 5|              |            |
                                           | 4| 5| 4| 4| 0| 4| 5| 6| 1| 4| 0| 9| 3| 0| 0| 0| 4| 0| 6| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     T      |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|              |     A      |
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
      Adenoma                              |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
      Renal Tubule, Adenoma                |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +        +  +  A  +  +               |  59        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +     +  +  +  +  +  +  +  +        +  +  +  +  +               |  60        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  46                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 0| 2| 5| 3| 6| 3| 3| 3| 2| 5| 5| 2| 3| 3| 3| 3| 2| 3| 6| 2| 2| 5| 3| 5|             
                                           | 9| 1| 9| 5| 0| 0| 4| 0| 3| 9| 6| 5| 9| 2| 3| 4| 0| 9| 0| 0| 9| 9| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +     +  +  M  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +     +  +  +  +        +  +  +  M  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +     +  +  I  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
      Adenocarcinoma                       |                                                       X                  |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Hepatocellular Carcinoma             |    X                                X  X     X        X     X            |             
      Hepatocellular Adenoma               |                         X                    X                    X     X|             
      Hepatocellular Adenoma, Multiple     | X  X              X  X                          X     X        X         |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                      X     X                                   X         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +     +  +  +  +        +  A  +  +  +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  A  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  A  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  A  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +     M  +  +  M        M  +  +  +  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     +  +  +  +        +  A  +  M  +  +  +     +  +     +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 0| 2| 5| 3| 6| 3| 3| 3| 2| 5| 5| 2| 3| 3| 3| 3| 2| 3| 6| 2| 2| 5| 3| 5|             
                                           | 9| 1| 9| 5| 0| 0| 4| 0| 3| 9| 6| 5| 9| 2| 3| 4| 0| 9| 0| 0| 9| 9| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                                                          |             
      C-Cell, Carcinoma                    |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +     +        +  +              +              +        +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                              X                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +     +  +  M  M        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  I  +     +     +  +  +  +        +  +  +  M  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M     M     M  M  M  M        M  M  M  M  M  M  M     M  M     M   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Basal Cell Adenoma                   |                                                                          |             
      Tail, Neurofibroma                   |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 4| 4| 7| 5| 7| 7| 7| 7| 7| 4| 7| 7| 4| 7| 4|             
                             DAY ON TEST   | 2| 0| 2| 5| 3| 6| 3| 3| 3| 2| 5| 5| 2| 3| 3| 3| 3| 2| 3| 6| 2| 2| 5| 3| 5|             
                                           | 9| 1| 9| 5| 0| 0| 4| 0| 3| 9| 6| 5| 9| 2| 3| 4| 0| 9| 0| 0| 9| 9| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +     +  +  +  +  +     +  +  +  +  +  +  +     +  +     +  +|             
      Alveolar/Bronchiolar Adenoma         |                   X           X                                         X|             
      Alveolar/Bronchiolar Carcinoma       |                                                       X                  |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +     +  +  +  +        +  +  +  +  +  +  +     +  +     +   |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Lymphocytic       |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 6| 2| 0| 2| 2| 2| 3| 2| 3| 5| 6| 5| 2| 2| 3| 6| 3| 2| 3| 3| 3| 6| 3| 5| 3|             
                                           | 0| 9| 7| 9| 9| 9| 3| 9| 4| 5| 0| 5| 9| 9| 3| 0| 4| 9| 3| 3| 3| 0| 0| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    I  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Adenocarcinoma                       |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +        +  +  +     +  +  +  +  +     +     +|             
      Hepatocellular Carcinoma             |       X                                                                  |             
      Hepatocellular Adenoma               |       X                             X     X                             X|             
      Hepatocellular Adenoma, Multiple     |          X  X           X              X              X           X      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |                X  X                             X                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  M  +  +  +  +  +           I  +  +     +  M  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  M  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 6| 2| 0| 2| 2| 2| 3| 2| 3| 5| 6| 5| 2| 2| 3| 6| 3| 2| 3| 3| 3| 6| 3| 5| 3|             
                                           | 0| 9| 7| 9| 9| 9| 3| 9| 4| 5| 0| 5| 9| 9| 3| 0| 4| 9| 3| 3| 3| 0| 0| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      C-Cell, Adenoma                      |                                        X                                 |             
      C-Cell, Carcinoma                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +     +        +                 +           +     +     +      |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Inguinal, Lymphoma Malignant         |                                                                          |             
          Lymphocytic                      |                                                                   X      |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Lymphocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  A  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X     X|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  M  +  M  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M  M  M  M  +  M  M           M  M  M     M  M  M  M  M     M     M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +        +  +  +  +     +  +  +  +  +     +     +|             
      Basal Cell Adenoma                   |                                                                          |             
      Tail, Neurofibroma                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 6| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 4| 7| 7| 7| 7| 7| 4| 7| 4| 7|             
                             DAY ON TEST   | 6| 2| 0| 2| 2| 2| 3| 2| 3| 5| 6| 5| 2| 2| 3| 6| 3| 2| 3| 3| 3| 6| 3| 5| 3|             
                                           | 0| 9| 7| 9| 9| 9| 3| 9| 4| 5| 0| 5| 9| 9| 3| 0| 4| 9| 3| 3| 3| 0| 0| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    50 MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Alveolar/Bronchiolar Adenoma         |          X                             X  X                              |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |       X                                                                  |             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +           +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +  +  +  +  +  +  +  +     +  +  +  +     +  +  +  +  +     +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                   X     X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 3| 6| 2| 2| 3| 3| 2| 3| 3| 6| 6| 5| 3| 6| 3| 3| 3| 5|              |            |
                                           | 0| 9| 3| 0| 9| 9| 0| 0| 9| 3| 3| 0| 0| 6| 0| 0| 4| 4| 4| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |     A      |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  47        |
      Adenocarcinoma                       |                                                                          |          1 |
      Adenoma                              |    X                                                                     |          1 |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  54        |
      Hepatocellular Carcinoma             | X                          X  X                 X                        |         11 |
      Hepatocellular Adenoma               |             X  X              X                                          |         11 |
      Hepatocellular Adenoma, Multiple     |    X  X           X     X                 X     X     X                  |         20 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
      Squamous Cell Carcinoma              |                                                    X                     |          1 |
      Squamous Cell Papilloma              |                      X     X                                             |          8 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  48        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  53                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 3| 6| 2| 2| 3| 3| 2| 3| 3| 6| 6| 5| 3| 6| 3| 3| 3| 5|              |            |
                                           | 0| 9| 3| 0| 9| 9| 0| 0| 9| 3| 3| 0| 0| 6| 0| 0| 4| 4| 4| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |     A      |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M     +  +  +  +  +  +  +           +     +  +  M                  |  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +           M     +  +  +                  |  46        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      C-Cell, Adenoma                      |                                                                          |          1 |
      C-Cell, Carcinoma                    |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                         +              +  +        +  +  +               |  21        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Inguinal, Lymphoma Malignant         |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Lymphocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  48        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +     +  +  +  +  +  +  +           +     +  +  +                  |  45        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  54                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 4| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 3| 6| 2| 2| 3| 3| 2| 3| 3| 6| 6| 5| 3| 6| 3| 3| 3| 5|              |            |
                                           | 0| 9| 3| 0| 9| 9| 0| 0| 9| 3| 3| 0| 0| 6| 0| 0| 4| 4| 4| 6|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |     T      |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|              |     A      |
    50 MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M     M  M  +  M  +  M  M           M     M  M  M                  |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  51        |
      Basal Cell Adenoma                   |                                           X                              |          1 |
      Tail, Neurofibroma                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  52        |
      Alveolar/Bronchiolar Adenoma         |    X                 X                    X           X                  |         10 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +                                                      |   1        |
      Adenoma                              |                   X                                                      |          1 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                       +                  |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     +  +  +  +  +  +  +           +     +  +  +                  |  50        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +     +  +  +  +  +  +  +        +  +     +  +  +  +               |  58        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          3 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  55                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 4| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 2| 6| 2| 3| 6| 3| 2| 2| 2| 5| 3| 5| 6| 2| 2| 3| 6| 5| 3| 5| 3|             
                                           | 1| 9| 3| 0| 9| 0| 9| 0| 0| 0| 9| 9| 9| 6| 3| 5| 0| 9| 9| 0| 0| 6| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +     +     +  +     +  +  +  +     +  +     +  +  +        +  +  +|             
      Hepatoblastoma                       | X                                                  X                     |             
      Hepatocellular Carcinoma             |                                                          X        X      |             
      Hepatocellular Adenoma               |    X                                      X        X  X  X               |             
      Hepatocellular Adenoma, Multiple     |                   X  X        X              X                    X      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
      Fat, Lymphoma Malignant              |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Lymphoma Malignant                   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Squamous Cell Carcinoma              | X                                                                        |             
      Squamous Cell Papilloma              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 4| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 2| 6| 2| 3| 6| 3| 2| 2| 2| 5| 3| 5| 6| 2| 2| 3| 6| 5| 3| 5| 3|             
                                           | 1| 9| 3| 0| 9| 0| 9| 0| 0| 0| 9| 9| 9| 6| 3| 5| 0| 9| 9| 0| 0| 6| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Adenoma                              |                            X                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +     +     M  +     +  +  +  +     +        +  M  +        +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +     +     +  +     +  +  +  +     I        +  +  +        +     M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +           +  +     +                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Lumbar, Lymphoma Malignant           |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
      Pancreatic, Lymphoma Malignant Mixed |                                     X                                    |             
      Renal, Lymphoma Malignant            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     M|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +     +  +     +|             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  M  +     +     +  +     +  +  I  +     +        +  +  +        +     +|             
      Lymphoma Malignant                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M     M     M  M     M  M  M  M     +        M  M  M        M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +     +     +  +     +  +  +  +     +  +     +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 4| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4| 7| 4| 4| 7| 7| 7| 4| 4| 7| 4| 7|             
                             DAY ON TEST   | 0| 2| 3| 6| 2| 6| 2| 3| 6| 3| 2| 2| 2| 5| 3| 5| 6| 2| 2| 3| 6| 5| 3| 5| 3|             
                                           | 1| 9| 3| 0| 9| 0| 9| 0| 0| 0| 9| 9| 9| 6| 3| 5| 0| 9| 9| 0| 0| 6| 3| 5| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
           Metastatic, Stomach             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Alveolar/Bronchiolar Adenoma         |       X           X           X                    X                    X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                          |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                   X      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
      Lymphoma Malignant                   |                                                                          |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +     +     +  +     +  +  +  +     +        +  +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +     +     +  +     +  +  +  +     +  +     +  +  +     +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Lymphocytic       |                                                                          |             
      Lymphoma Malignant Mixed             |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 6| 2| 3| 5| 3| 5| 5| 3| 3| 2| 3| 3| 3| 6| 2| 3| 5| 3| 3| 6| 2| 3| 3| 2| 6|             
                                           | 0| 9| 3| 6| 3| 6| 5| 0| 0| 9| 6| 0| 3| 0| 9| 0| 6| 0| 3| 7| 9| 0| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +        +  +  I  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     +        +  +  +  +  +  +     +  M     +  +  +  +  M  +  +   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Lymphoma Malignant                   |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +   |             
      Hepatoblastoma                       |                                                    X              X  X   |             
      Hepatocellular Carcinoma             |                               X                    X                     |             
      Hepatocellular Adenoma               |                                     X     X              X           X   |             
      Hepatocellular Adenoma, Multiple     |    X  X     X                    X           X     X           X  X      |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
      Fat, Lymphoma Malignant              |                                                          X               |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Lymphoma Malignant                   |                                                          X               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Squamous Cell Carcinoma              |                                                                          |             
      Squamous Cell Papilloma              |             X                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +     +  +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     M        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 6| 2| 3| 5| 3| 5| 5| 3| 3| 2| 3| 3| 3| 6| 2| 3| 5| 3| 3| 6| 2| 3| 3| 2| 6|             
                                           | 0| 9| 3| 6| 3| 6| 5| 0| 0| 9| 6| 0| 3| 0| 9| 0| 6| 0| 3| 7| 9| 0| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +        M  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     M        M  +  +  +  M  +     +  +     M  +  M  M  +  +  +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                               +  +           +              +  +         |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Lumbar, Lymphoma Malignant           |                                                          X               |             
      Mediastinal, Lymphoma Malignant      |                                                          X               |             
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |             
      Renal, Lymphoma Malignant            |                                                          X               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant                   |                                                          X               |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +        +  +  +  I  +  +     +  +     +  +  +  +  +  +  +   |             
      Lymphoma Malignant                   |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M     M        M  M  M  M  M  M     M  M     M  M  M  M  M  M  M   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 4| 7| 4| 4| 7| 7| 7| 6| 7| 7| 4| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 6| 2| 3| 5| 3| 5| 5| 3| 3| 2| 3| 3| 3| 6| 2| 3| 5| 3| 3| 6| 2| 3| 3| 2| 6|             
                                           | 0| 9| 3| 6| 3| 6| 5| 0| 0| 9| 6| 0| 3| 0| 9| 0| 6| 0| 3| 7| 9| 0| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    100MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
           Metastatic, Stomach             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Alveolar/Bronchiolar Adenoma         |             X                             X                    X     X   |             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                  X                    X                  |             
      Alveolar/Bronchiolar Carcinoma       |             X           X                                                |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Liver                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
      Lymphoma Malignant                   |                                                          X               |             
      Squamous Cell Carcinoma, Metastatic, |                                                                          |             
           Stomach                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +        +  +  +  +  +  +     +  +     +  +  +  +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +     +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +   |             
      Lymphoma Malignant                   |                                                          X               |             
      Lymphoma Malignant Lymphocytic       |                                     X                                    |             
      Lymphoma Malignant Mixed             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1|              |            |
                                           | 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |     A      |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  M               |  47        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  49        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +  +  M  +     +  +     +  +     +  +  +  +  A               |  49        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  56        |
      Hepatoblastoma                       |                                                                          |          5 |
      Hepatocellular Carcinoma             |                                                 X                        |          5 |
      Hepatocellular Adenoma               | X           X        X                                                   |         12 |
      Hepatocellular Adenoma, Multiple     |                X                    X  X     X     X                     |         18 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                                             |   3        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                            X                                             |          1 |
      Fat, Lymphoma Malignant              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
      Squamous Cell Carcinoma              |                            X                                             |          2 |
      Squamous Cell Papilloma              |                X                                                         |          2 |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  A               |  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  62                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1|              |            |
                                           | 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |     A      |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +     +  +  +  +  +     M  +     +  +     +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +     +  +  +  +  +     M  +     +  +     +  +  +  +  +               |  49        |
      Adenoma                              |          X                                                               |          1 |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +     +  +  +  +  +     M  +     +  +     +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Adenoma                              |          X                             X                                 |          3 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +     M  M  +  +  +     +  +     +  +     +  +  +  +  +               |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  M  M               |  40        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                 +                 +     +                  |  13        |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +     +  +  +  +  +     I  +     +  +     +  +  +  +  +               |  49        |
      Lumbar, Lymphoma Malignant           |                                                                          |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant Mixed |                                                                          |          1 |
      Renal, Lymphoma Malignant            |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +     +  +  +  M  +     I  +     +  +     +  +  +  +  +               |  48        |
      Lymphoma Malignant                   |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M     +  +  +  +  +     M  +     +  +     +  +  +  +  +               |  47        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                               X                                          |          2 |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  51        |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant                   |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +     +  +  I  +  +     +  +     +  +     +  +  +  +  +               |  44        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  63                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1|              |            |
                                           | 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |     A      |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                                                                          |          1 |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +     M  +  M  M  M     M  M     M  M     M  M  M  M  M               |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  51        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   1        |
      Diaphragm, Squamous Cell Carcinoma,  |                                                                          |            |
           Metastatic, Stomach             |                            X                                             |          1 |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  51        |
      Alveolar/Bronchiolar Adenoma         |          X                    X                    X                     |         12 |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                                                                          |          2 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          2 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Liver                           |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   1        |
      Adenoma                              |                                                       X                  |          1 |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
      Lymphoma Malignant                   |                                                                          |          1 |
      Squamous Cell Carcinoma, Metastatic, |                                                                          |            |
           Stomach                         |                            X                                             |          1 |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +     +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  50        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         | +  +  +  +  +  +  +  +     +  +     +  +     +  +  +  +  +               |  57        |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  64                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 4| 7| 7| 7| 0| 7| 4| 5| 7| 4| 7| 7| 4| 7| 7| 7| 7| 4|              |            |
                             DAY ON TEST   | 3| 2| 5| 2| 3| 2| 6| 3| 6| 6| 2| 6| 2| 3| 5| 3| 3| 2| 2| 1|              |            |
                                           | 0| 5| 5| 9| 4| 9| 4| 4| 0| 7| 9| 0| 9| 4| 5| 3| 4| 9| 3| 9|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|              |     A      |
    100MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Lymphoma Malignant                   |                               X                                          |          2 |
      Lymphoma Malignant Lymphocytic       |                                                                          |          1 |
      Lymphoma Malignant Mixed             |                                                                          |          1 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  65                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 5| 5| 5| 3| 3| 2| 2| 6| 3| 3| 2| 2| 1| 3| 3| 9| 2| 2| 3| 3| 3| 2| 3| 2|             
                                           | 4| 6| 5| 9| 0| 0| 9| 9| 0| 3| 4| 9| 9| 2| 3| 3| 8| 9| 9| 4| 3| 0| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  A  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +     I  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hepatoblastoma                       |                                                                          |             
      Hepatocellular Carcinoma             |                               X                                          |             
      Hepatocellular Adenoma               | X     X     X                 X  X           X     X     X               |             
      Hepatocellular Adenoma, Multiple     |                X  X  X              X  X                       X  X  X   |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                                                   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pheochromocytoma Benign              |             X                                                            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  M  +     +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +     +  M  M  +  +  M  M  +  M  +  +  +  M  +  I  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Adenoma             |                   X                                                      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +                       +              +     +     +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 5| 5| 5| 3| 3| 2| 2| 6| 3| 3| 2| 2| 1| 3| 3| 9| 2| 2| 3| 3| 3| 2| 3| 2|             
                                           | 4| 6| 5| 9| 0| 0| 9| 9| 0| 3| 4| 9| 9| 2| 3| 3| 8| 9| 9| 4| 3| 0| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                  X                                       |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                        X                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +     +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A  +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                        X                                 |             
      Lymphoma Malignant                   |                                  X                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                        X                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +     +  +  I  M  I  +  +  M  +  +  +  +  +  I  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M     M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |          X           X        X     X        X              X     X  X  X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                   X              X        X                              |             
      Alveolar/Bronchiolar Carcinoma       |                                                                          |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Metastatic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 4| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 5| 5| 5| 3| 3| 2| 2| 6| 3| 3| 2| 2| 1| 3| 3| 9| 2| 2| 3| 3| 3| 2| 3| 2|             
                                           | 4| 6| 5| 9| 0| 0| 9| 9| 0| 3| 4| 9| 9| 2| 3| 3| 8| 9| 9| 4| 3| 0| 9| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | A  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                  X                                       |             
      Lymphoma Malignant Histiocytic       |                                        X                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 4| 7| 1| 7| 4| 4| 4| 4| 5| 3| 6| 6| 4| 4| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 5| 2| 6| 3| 3| 6| 3| 7| 3| 6| 5| 6| 6| 5| 2| 6| 0| 7| 6| 5| 3| 3| 3| 8|             
                                           | 0| 5| 9| 0| 3| 0| 0| 4| 7| 0| 0| 6| 0| 0| 8| 3| 1| 8| 6| 0| 5| 0| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +     +  +     +  A  +     +        A  M  A  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +     +  +     +  A  +     +        A  A  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +     +  +     +  A  +     +        A  A  +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +     +  +     +  A  +     +        A  A  A  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Hepatoblastoma                       |       X                                                                  |             
      Hepatocellular Carcinoma             |       X                                   X                              |             
      Hepatocellular Adenoma               |                      X     X                          X           X     X|             
      Hepatocellular Adenoma, Multiple     |             X  X                                                         |             
      Histiocytic Sarcoma                  |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +     +  +     +  A  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +     +  +     +  +  +     +        A  A  +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +     +  +     +  +  +     +        A  A  +  +  +     +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +     +  +     +  A  +     +        A  A  +  +  +     +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     +  +     +  +  +     +        +  M  +  +  +     +  +  +  +  +|             
      Pheochromocytoma Benign              |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +     +  +     +  A  +     +        +  +  +  +  +     +  +  +  +  +|             
      Adenoma                              |                            X                                      X      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +     +  +     +  M  M     +        +  M  +  +  +     +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +     +  +     +  +  +     +        +  M  +  +  +     +  +  I  +  M|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Follicular Cell, Adenoma             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +     +  +     +  +  +     +        A  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                              +                 +         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 4| 7| 1| 7| 4| 4| 4| 4| 5| 3| 6| 6| 4| 4| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 5| 2| 6| 3| 3| 6| 3| 7| 3| 6| 5| 6| 6| 5| 2| 6| 0| 7| 6| 5| 3| 3| 3| 8|             
                                           | 0| 5| 9| 0| 3| 0| 0| 4| 7| 0| 0| 6| 0| 0| 8| 3| 1| 8| 6| 0| 5| 0| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +     +  +     +  +  +     +        A  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +     +  +     +  +  +     +        A  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Mediastinal, Lymphoma Malignant      |                                                                          |             
      Pancreatic, Lymphoma Malignant       |                                                                          |             
          Histiocytic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |    +  +     +  +     M  +  +     M        +  M  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Lymphoma Malignant Histiocytic       |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +  +     +  +  +     +        A  +  +  +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +     +  +     +  +  +     +        I  +  +  M  +     +  +  +  +  A|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  M     +  M     M  M  M     M        M  M  M  M  M     M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +     +  +     +  +  +     +        A  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Alveolar/Bronchiolar Adenoma         |                      X     X     X        X                 X        X  X|             
      Alveolar/Bronchiolar Adenoma,        |                                                                          |             
          Multiple                         |                                                                X         |             
      Alveolar/Bronchiolar Carcinoma       |             X                                                            |             
      Hepatocellular Carcinoma, Metastatic,|                                                                          |             
           Metastatic                      |                                           X                              |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 4| 7| 7| 4| 7| 1| 7| 4| 4| 4| 4| 5| 3| 6| 6| 4| 4| 4| 7| 7| 7| 6|             
                             DAY ON TEST   | 6| 5| 2| 6| 3| 3| 6| 3| 7| 3| 6| 5| 6| 6| 5| 2| 6| 0| 7| 6| 5| 3| 3| 3| 8|             
                                           | 0| 5| 9| 0| 3| 0| 0| 4| 7| 0| 0| 6| 0| 0| 8| 3| 1| 8| 6| 0| 5| 0| 0| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    200MG/KG                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Adenoma                              |                                                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                    +                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +     +  +     +  A  +     +        A  +  +  +  +     +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SYSTEMIC LESIONS                          |                                                                          |             
                                            __________________________________________________________________________|             
   Multiple Organs                         |    +  +     +  +     +  +  +     +        +  +  +  +  +     +  +  +  +  +|             
      Histiocytic Sarcoma                  |                                                                          |             
      Lymphoma Malignant                   |                                                                          |             
      Lymphoma Malignant Histiocytic       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 2| 1| 6| 2| 2| 5| 2| 3| 5| 5| 2| 9| 4| 2| 2| 2| 2| 5| 3|              |            |
                                           | 0| 9| 2| 0| 9| 9| 5| 9| 3| 6| 6| 9| 2| 1| 9| 9| 9| 9| 5| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +  +     +  +  M  +  +  M  +  +  A  +  +  +  +  +  M  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  A     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Hepatoblastoma                       |                                                                          |          1 |
      Hepatocellular Carcinoma             |                                                                          |          3 |
      Hepatocellular Adenoma               |                   X                             X     X                  |         16 |
      Hepatocellular Adenoma, Multiple     |    X                 X                 X  X                              |         14 |
      Histiocytic Sarcoma                  |                                                          X               |          1 |
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  56        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  A     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +     +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  58        |
      Pheochromocytoma Benign              |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Adenoma                              |                                                                          |          2 |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  M     +  +  +  +  M  +  +  +  M  M  +  +  +  +  M  +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  M     +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Follicular Cell, Adenoma             |                                                          X               |          2 |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  72                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 2| 1| 6| 2| 2| 5| 2| 3| 5| 5| 2| 9| 4| 2| 2| 2| 2| 5| 3|              |            |
                                           | 0| 9| 2| 0| 9| 9| 5| 9| 3| 6| 6| 9| 2| 1| 9| 9| 9| 9| 5| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +        +                                                |   9        |
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Histiocytic Sarcoma                  |                                                          X               |          1 |
      Mediastinal, Lymphoma Malignant      |                                                                          |          1 |
      Pancreatic, Lymphoma Malignant       |                                                                          |            |
          Histiocytic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |    +  +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  54        |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  56        |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          2 |
      Lymphoma Malignant                   |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
      Histiocytic Sarcoma                  |                                                          X               |          1 |
      Lymphoma Malignant Histiocytic       |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  M     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +               |  50        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    M  M     M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M               |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  59        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Alveolar/Bronchiolar Adenoma         |    X        X                       X        X        X  X               |         22 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  73                                                               
NTP Experiment-Test: 05090-02                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04
Study Type: CHRONIC                                              COUMARIN                                         Date: 04/07/97  
Route: GAVAGE                                                                                                     Time: 13:10:57  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 4| 4| 7| 7| 4| 7| 7| 4| 4| 7| 6| 5| 7| 7| 7| 7| 4| 7|              |            |
                             DAY ON TEST   | 6| 2| 1| 6| 2| 2| 5| 2| 3| 5| 5| 2| 9| 4| 2| 2| 2| 2| 5| 3|              |            |
                                           | 0| 9| 2| 0| 9| 9| 5| 9| 3| 6| 6| 9| 2| 1| 9| 9| 9| 9| 5| 4|              |            |
 _____________________________________________________________________________________________________________________|     T (*)  |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |     O      |
   B6C3F1 MICE MALE                        | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |     T      |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|              |     A      |
    200MG/KG                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|              |     L      |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar/Bronchiolar Adenoma,        |                                                                          |            |
          Multiple                         |                      X                                                   |          5 |
      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |
      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |
           Metastatic                      |                                                                          |          1 |
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   1        |
      Adenoma                              |                               X                                          |          1 |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                               +                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  58        |
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +     +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +               |  57        |
 __________________________________________________________________________________________________________________________________ 
 SYSTEMIC LESIONS                          |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Multiple Organs                         |    +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +               |  60        |
      Histiocytic Sarcoma                  |                                                          X               |          1 |
      Lymphoma Malignant                   |                                                                          |          1 |
      Lymphoma Malignant Histiocytic       |                      X                                                   |          2 |
 __________________________________________________________________________________________________________________________________ 
                         * : Total animals with tissue examined microscopically; total animals with tumor                           
                         + : Tissue examined microscopically                      M : Missing tissue                                
                         X : Lesion present                                       A : Autolysis precludes evaluation                
                         I : Insufficient tissue                              BLANK : Not examined microscopically                  
                                                             Page  74                                                               
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