Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/1212

TDMS Study 05090-01 Pathology Tables



                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                              COUMARIN


NTP Experiment-Test: 05090-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/12/94
Route: GAVAGE                                                                                                     Time: 03:12:33




       Facility:  American Biogenics Corp.

       Chemical CAS #:  000091645

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      25 MG/KG     50 MG/KG     100MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          14            7            7           14                                     
    Dead                                               5            4            2            6                                     
    Gavage Death                                       2            1            5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           38           35           30                                     
    Dead                                                                         1                                                  
  Animals Examined Microscopically                    60           60           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (57)         (48)         (48)         (58)                                   
      Ulcer                                                                                   2 (3%)                                
   Liver                                              (60)         (58)         (58)         (60)                                   
      Basophilic Focus                                39 (65%)     33 (57%)     17 (29%)     21 (35%)                               
      Clear Cell Focus                                              1 (2%)                    3 (5%)                                
      Cytologic Alterations                                                                   9 (15%)                               
      Developmental Malformation                       6 (10%)      4 (7%)       9 (16%)      6 (10%)                               
      Eosinophilic Focus                                            1 (2%)       1 (2%)       2 (3%)                                
      Fatty Change                                     5 (8%)                   12 (21%)     17 (28%)                               
      Fibrosis                                                                   1 (2%)      12 (20%)                               
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Inflammation, Chronic                           19 (32%)     24 (41%)     21 (36%)     21 (35%)                               
      Inflammation, Suppurative                        1 (2%)                    1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Mixed Cell Focus                                 6 (10%)                   1 (2%)       3 (5%)                                
      Necrosis                                                                   1 (2%)                                             
      Necrosis, Coagulative                            3 (5%)       3 (5%)       4 (7%)      15 (25%)                               
      Bile Duct, Cyst                                                            1 (2%)                                             
      Bile Duct, Hyperplasia                          27 (45%)     30 (52%)     30 (52%)     23 (38%)                               
      Hepatocyte, Cytologic Alterations                                                       1 (2%)                                
      Hepatocyte, Degeneration, Granular                                        11 (19%)     39 (65%)                               
   Mesentery                                          (3)          (8)          (10)         (7)                                    
      Fat, Cyst                                                     1 (13%)                                                         
      Fat, Inflammation, Chronic                                    1 (13%)      2 (20%)      2 (29%)                               
      Fat, Mineralization                                           2 (25%)      1 (10%)                                            
      Fat, Necrosis, Coagulative                       3 (100%)     5 (63%)      6 (60%)      2 (29%)                               
   Pancreas                                           (59)         (49)         (48)         (56)                                   
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Acinus, Atrophy                                  6 (10%)      1 (2%)       4 (8%)       4 (7%)                                
      Acinus, Hyperplasia                                                                     1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      25 MG/KG     50 MG/KG     100MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Salivary Glands                                    (60)         (50)         (50)         (60)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
   Stomach, Forestomach                               (58)         (50)         (50)         (58)                                   
      Developmental Malformation                       1 (2%)                                                                       
      Hyperkeratosis                                                2 (4%)       1 (2%)       1 (2%)                                
      Hyperplasia, Squamous                                         2 (4%)                                                          
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Suppurative                                     1 (2%)                                                          
      Ulcer                                            1 (2%)       1 (2%)       6 (12%)      9 (16%)                               
   Stomach, Glandular                                 (58)         (50)         (49)         (57)                                   
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                            4 (7%)                    1 (2%)       7 (12%)                               
   Tongue                                             (1)                                    (1)                                    
      Hyperkeratosis                                                                          1 (100%)                              
      Hyperplasia                                      1 (100%)                                                                     
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)                                                 
      Polyarteritis, Chronic                                                     1 (100%)                                           
   Heart                                              (60)         (50)         (50)         (60)                                   
      Cardiomyopathy                                  27 (45%)     20 (40%)     22 (44%)     23 (38%)                               
      Fibrosis                                         2 (3%)                    2 (4%)       1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Mineralization                                   1 (2%)                                 2 (3%)                                
      Thrombosis                                       2 (3%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (50)         (48)         (60)                                   
      Atrophy                                          1 (2%)                                                                       
      Clear Cell Focus                                 3 (5%)       1 (2%)       2 (4%)       1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
   Adrenal Gland, Medulla                             (60)         (50)         (48)         (59)                                   
      Basophilic Focus                                 2 (3%)       1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
   Parathyroid Gland                                  (55)         (47)         (45)         (57)                                   
      Hyperplasia                                                                3 (7%)       1 (2%)                                
   Pituitary Gland                                    (58)         (48)         (48)         (59)                                   
      Pars Distalis, Congestion                                     1 (2%)                                                          
      Pars Distalis, Cyst                              5 (9%)       8 (17%)      7 (15%)      6 (10%)                               
      Pars Distalis, Pigmentation, Melanin             1 (2%)                                                                       
      Pars Intermedia, Congestion                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      25 MG/KG     50 MG/KG     100MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Pars Nervosa, Cyst Multilocular                                            1 (2%)                                             
   Thyroid Gland                                      (59)         (50)         (49)         (59)                                   
      C-Cell, Hyperplasia                              6 (10%)      5 (10%)      6 (12%)      4 (7%)                                
      Follicle, Cyst                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (58)         (47)         (49)         (59)                                   
      Inflammation, Suppurative                        4 (7%)      10 (21%)      7 (14%)      4 (7%)                                
      Duct, Dilatation                                 2 (3%)       2 (4%)       4 (8%)       1 (2%)                                
   Ovary                                              (60)         (50)         (50)         (59)                                   
      Corpus Luteum, Cyst                              2 (3%)                    1 (2%)                                             
      Follicle, Cyst                                   4 (7%)       3 (6%)       1 (2%)       2 (3%)                                
   Uterus                                             (60)         (51)         (52)         (59)                                   
      Hydrometra                                       9 (15%)      5 (10%)      8 (15%)     12 (20%)                               
      Hyperplasia, Cystic                              3 (5%)       3 (6%)       1 (2%)       1 (2%)                                
      Necrosis, Coagulative                            1 (2%)                                                                       
      Cervix, Cyst                                                  1 (2%)                                                          
      Cervix, Inflammation, Suppurative                1 (2%)                                                                       
      Epithelium, Cytoplasmic Alteration                                                      1 (2%)                                
   Vagina                                             (1)          (1)                       (4)                                    
      Cyst                                             1 (100%)                                                                     
      Hyperkeratosis                                                                          1 (25%)                               
      Inflammation, Suppurative                                     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)          (1)                                                              
      Anisocytosis                                                  1 (100%)                                                        
      Monocytosis                                                   1 (100%)                                                        
   Bone Marrow                                        (60)         (50)         (49)         (59)                                   
      Hyperplasia, Neutrophil                                                    1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Myelofibrosis                                                                           1 (2%)                                
   Lymph Node                                         (59)         (50)         (50)         (59)                                   
      Mediastinal, Hyperplasia, Macrophage                                                    1 (2%)                                
      Pancreatic, Hemorrhage, Acute                                              1 (2%)                                             
      Pancreatic, Inflammation, Suppurative            1 (2%)                                                                       
   Lymph Node, Mandibular                             (59)         (47)         (48)         (57)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                 1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      25 MG/KG     50 MG/KG     100MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Macrophage                                       1 (2%)                                                          
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
   Lymph Node, Mesenteric                             (57)         (49)         (49)         (59)                                   
      Congestion                                                    2 (4%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Spleen                                             (59)         (51)         (49)         (59)                                   
      Congestion                                                    2 (4%)       1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                                         2 (4%)       1 (2%)                                             
      Pigmentation, Hemosiderin                                     3 (6%)       1 (2%)       1 (2%)                                
      Sinusoid, Dilatation                                                       1 (2%)                                             
   Thymus                                             (58)         (48)         (49)         (56)                                   
      Congestion                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (50)         (50)         (59)                                   
      Galactocele                                      6 (10%)      4 (8%)       3 (6%)       1 (2%)                                
      Hyperplasia, Glandular                           1 (2%)                                                                       
      Inflammation                                     1 (2%)       1 (2%)                                                          
   Skin                                               (60)         (50)         (51)         (60)                                   
      Cyst Epithelial Inclusion                                     2 (4%)                    2 (3%)                                
      Inflammation, Suppurative                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (50)         (50)         (60)                                   
      Fracture                                                                                1 (2%)                                
      Osteopetrosis                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (50)         (50)         (59)                                   
      Cerebrum, Atypia Cellular                        1 (2%)                                                                       
      Cerebrum, Hemorrhage                             1 (2%)                    1 (2%)                                             
      Cerebrum, Mineralization                         1 (2%)                                                                       
      Hypothalamus, Compression                        1 (2%)       2 (4%)       3 (6%)       2 (3%)                                
      Hypothalamus, Developmental Malformation         1 (2%)                                                                       
      Hypothalamus, Hemorrhage                                      2 (4%)                                                          
      Meninges, Hemorrhage                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   VEHICLE      25 MG/KG     50 MG/KG     100MG/KG                                  
                                                   CONTROL                                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (49)         (50)         (60)                                   
      Congestion                                                    2 (4%)       1 (2%)                                             
      Edema                                            2 (3%)                                                                       
      Foreign Body                                                               4 (8%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation                                     1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Alveolus, Inflammation, Chronic                                                         1 (2%)                                
   Nose                                               (60)         (50)         (50)         (59)                                   
      Congestion                                                                 1 (2%)                                             
      Fungus                                           1 (2%)                                 1 (2%)                                
      Inflammation, Suppurative                        4 (7%)       2 (4%)                   14 (24%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (4)          (1)          (1)                                    
      Anterior Chamber, Edema                                                                 1 (100%)                              
      Cornea, Edema                                                                           1 (100%)                              
      Lens, Cataract                                   1 (100%)     3 (75%)                                                         
      Retina, Degeneration                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (58)         (60)         (59)                                   
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                   2 (3%)       1 (2%)       1 (2%)                                             
      Nephropathy                                     38 (64%)     52 (90%)     54 (90%)     59 (100%)                              
      Cortex, Cyst                                                               1 (2%)       2 (3%)                                
   Urinary Bladder                                    (59)         (49)         (49)         (57)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      25 MG/KG     50 MG/KG     100MG/KG        
                                                   CONTROL      39 KILL      65 KILL                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           20           10           60           60           60           
  Scheduled Sacrifice                                 10           17            7           10            9           10           
  Early Deaths                                                                                                                      
    Moribund                                          14                                     31           33           31           
    Gavage Death                                       2            2            3            3            2            2           
    Dead                                               6            1                         7           13           17           
    Moribund Sacrifice                                                                                     1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                28                                      9            2                        
  Animals Examined Microscopically                    59           20           10           60           60           60           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (59)         (3)          (10)         (49)         (51)         (60)         
      Inflammation, Suppurative                                                               1 (2%)                                
      Periesophageal Tissue, Hemorrhage                                                       1 (2%)                                
   Intestine Large, Colon                             (55)         (2)          (10)         (48)         (42)         (54)         
      Inflammation, Suppurative                                                               1 (2%)                                
   Intestine Small, Duodenum                          (56)         (2)          (9)          (48)         (48)         (56)         
      Ulcer                                            1 (2%)                                 1 (2%)       2 (4%)       3 (5%)      
   Liver                                              (59)         (20)         (10)         (60)         (60)         (60)         
      Basophilic Focus                                16 (27%)                   1 (10%)      5 (8%)       2 (3%)       4 (7%)      
      Clear Cell Focus                                 5 (8%)       1 (5%)       1 (10%)                                1 (2%)      
      Cyst                                                                                                              1 (2%)      
      Cytologic Alterations                                                                               28 (47%)     29 (48%)     
      Developmental Malformation                       2 (3%)                                 1 (2%)       1 (2%)       4 (7%)      
      Eosinophilic Focus                               5 (8%)                                 1 (2%)                    3 (5%)      
      Fatty Change                                     4 (7%)       4 (20%)      2 (20%)     14 (23%)     15 (25%)      6 (10%)     
      Fibrosis                                                                                3 (5%)      41 (68%)     42 (70%)     
      Hemorrhage                                                                                                        3 (5%)      
      Hyperplasia                                      2 (3%)                                 2 (3%)                    2 (3%)      
      Infiltration Cellular, Lymphocyte                3 (5%)                                 1 (2%)                                
      Inflammation, Chronic                            1 (2%)                    1 (10%)      1 (2%)                                
      Inflammation, Suppurative                                                               3 (5%)       3 (5%)       2 (3%)      
      Mineralization                                                                                                    2 (3%)      
      Mixed Cell Focus                                 4 (7%)                                 1 (2%)       1 (2%)                   
      Necrosis, Coagulative                            1 (2%)                                13 (22%)     38 (63%)     41 (68%)     
      Bile Duct, Hyperplasia                          47 (80%)      7 (35%)      6 (60%)     49 (82%)     54 (90%)     56 (93%)     
      Hepatocyte, Degeneration, Granular                                                      8 (13%)      8 (13%)      6 (10%)     
      Periductular, Fibrosis                                                                  1 (2%)                                
   Mesentery                                          (21)         (1)          (3)          (12)         (18)         (7)          
      Ectopic Tissue                                                                                       1 (6%)                   
      Fat, Hemorrhage                                  1 (5%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      25 MG/KG     50 MG/KG     100MG/KG        
                                                   CONTROL      39 KILL      65 KILL                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Inflammation, Chronic                       2 (10%)      1 (100%)     1 (33%)      1 (8%)       1 (6%)       1 (14%)     
      Fat, Inflammation, Suppurative                                                          4 (33%)                   2 (29%)     
      Fat, Necrosis, Coagulative                      14 (67%)                   2 (67%)      8 (67%)     16 (89%)      3 (43%)     
   Pancreas                                           (57)         (20)         (9)          (49)         (50)         (59)         
      Atrophy                                          4 (7%)       1 (5%)                    7 (14%)      2 (4%)       1 (2%)      
      Fibrosis                                                                                             2 (4%)                   
      Infiltration Cellular, Lymphocyte                                                                                 1 (2%)      
      Inflammation, Chronic                                                                   1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                    1 (2%)      
      Acinar Cell, Hyperplasia                         1 (2%)                                                                       
      Acinus, Hyperplasia                              2 (4%)                                 1 (2%)                                
      Vein, Dilatation                                                                        1 (2%)                                
   Salivary Glands                                    (59)         (3)          (10)         (49)         (49)         (60)         
      Inflammation, Suppurative                                                               1 (2%)                                
      Necrosis, Caseous                                                                                    1 (2%)                   
   Stomach, Forestomach                               (58)         (20)         (10)         (51)         (51)         (60)         
      Hyperkeratosis                                   2 (3%)                                 3 (6%)       4 (8%)                   
      Inflammation, Chronic                                                                   3 (6%)       5 (10%)      4 (7%)      
      Inflammation, Suppurative                                                               3 (6%)       1 (2%)       3 (5%)      
      Mineralization                                                                                                    1 (2%)      
      Ulcer                                            7 (12%)                               24 (47%)     35 (69%)     34 (57%)     
   Stomach, Glandular                                 (57)         (20)         (10)         (48)         (49)         (60)         
      Inflammation, Chronic                                                                   2 (4%)       3 (6%)       1 (2%)      
      Inflammation, Suppurative                                                               1 (2%)                    1 (2%)      
      Mineralization                                                                          4 (8%)       5 (10%)      5 (8%)      
      Ulcer                                            2 (4%)                                 5 (10%)      8 (16%)      7 (12%)     
   Tongue                                                                                                              (1)          
      Necrosis, Zenkers                                                                                                 1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                    (4)          (2)          (1)          
      Aorta, Mineralization                                                                   1 (25%)                   1 (100%)    
      Mesenteric Artery, Arteriosclerosis                                                     1 (25%)                               
      Mesenteric Artery, Polyarteritis                                                                     2 (100%)                 
      Mesenteric Artery, Thrombosis                                                                        1 (50%)                  
   Heart                                              (59)         (20)         (10)         (49)         (51)         (60)         
      Cardiomyopathy                                  36 (61%)     11 (55%)      8 (80%)     34 (69%)     25 (49%)     23 (38%)     
      Inflammation, Suppurative                                                                            1 (2%)                   
      Thrombosis                                                                              1 (2%)                                
      Atrioventricular Valve, Inflammation, Chronic                                                                     1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      25 MG/KG     50 MG/KG     100MG/KG        
                                                   CONTROL      39 KILL      65 KILL                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (19)         (10)         (50)         (50)         (60)         
      Clear Cell Focus                                                                        1 (2%)       1 (2%)       2 (3%)      
      Cytoplasmic Alteration                                                                  1 (2%)                                
      Hypertrophy                                                                             1 (2%)                                
   Adrenal Gland, Medulla                             (59)         (19)         (10)         (50)         (50)         (60)         
      Basophilic Focus                                 1 (2%)                                 1 (2%)                                
      Congestion                                       1 (2%)                                                                       
      Hyperplasia                                                                             4 (8%)                                
   Parathyroid Gland                                  (51)         (19)         (10)         (47)         (49)         (57)         
      Hyperplasia                                      3 (6%)                                20 (43%)     31 (63%)     29 (51%)     
   Pituitary Gland                                    (58)         (20)         (10)         (48)         (51)         (60)         
      Pars Distalis, Cyst                              1 (2%)                                 4 (8%)                    3 (5%)      
      Pars Distalis, Hyperplasia                                    1 (5%)       1 (10%)                                            
      Pars Distalis, Hypertrophy                                                 1 (10%)      1 (2%)                                
      Pars Intermedia, Hemorrhage                      1 (2%)                                                                       
   Thyroid Gland                                      (57)         (20)         (10)         (49)         (49)         (60)         
      C-Cell, Hyperplasia                              6 (11%)                                3 (6%)       1 (2%)       2 (3%)      
      Follicle, Cyst                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (2)                                                 (1)          (1)          
      Inflammation, Chronic                                                                                             1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (55)         (3)          (10)         (49)         (50)         (56)         
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                 2 (4%)       1 (2%)                   
      Inflammation, Suppurative                        8 (15%)                   1 (10%)      6 (12%)      3 (6%)       2 (4%)      
      Duct, Dilatation                                 3 (5%)                                              2 (4%)       3 (5%)      
   Prostate                                           (55)         (20)         (10)         (50)         (50)         (59)         
      Edema                                                                                                1 (2%)                   
      Hyperplasia                                      1 (2%)                                 2 (4%)       1 (2%)                   
      Inflammation, Chronic                                                                                             1 (2%)      
      Inflammation, Suppurative                        4 (7%)                                 7 (14%)      6 (12%)      5 (8%)      
   Seminal Vesicle                                    (55)         (20)         (10)         (50)         (50)         (59)         
      Atrophy                                                       1 (5%)                                                          
   Testes                                             (55)         (20)         (10)         (58)         (54)         (60)         
      Interstitial Cell, Hyperplasia                   3 (5%)       9 (45%)      1 (10%)      2 (3%)       2 (4%)       2 (3%)      
      Seminiferous Tubule, Atrophy                     3 (5%)       1 (5%)                                 1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      25 MG/KG     50 MG/KG     100MG/KG        
                                                   CONTROL      39 KILL      65 KILL                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)         (3)          (10)         (50)         (50)         (60)         
      Hyperplasia, Mononuclear Cell                    1 (2%)                                                                       
      Hyperplasia, Neutrophil                                                                 1 (2%)                                
   Lymph Node                                         (59)         (20)         (10)         (50)         (49)         (58)         
      Lumbar, Hemorrhage                                                                      1 (2%)       1 (2%)       3 (5%)      
      Mediastinal, Hemorrhage                                                                 2 (4%)                    1 (2%)      
      Mediastinal, Pigmentation                                                                                         1 (2%)      
      Renal, Hemorrhage                                                                       1 (2%)                                
   Lymph Node, Mandibular                             (57)         (20)         (10)         (47)         (48)         (58)         
      Congestion                                       1 (2%)                                                                       
      Edema                                                                      1 (10%)                                1 (2%)      
      Hyperplasia, Lymphoid                            1 (2%)                                 2 (4%)       3 (6%)       5 (9%)      
      Hyperplasia, Plasma Cell                         1 (2%)                                 2 (4%)                                
      Infiltration Cellular, Histiocyte                                                                                 1 (2%)      
   Lymph Node, Mesenteric                             (53)         (4)          (10)         (50)         (48)         (60)         
      Hyperplasia, Lymphoid                                                                                1 (2%)                   
      Infiltration Cellular, Histiocyte                                                       1 (2%)                                
      Pigmentation, Hemosiderin                                                                                         1 (2%)      
   Spleen                                             (58)         (20)         (10)         (50)         (51)         (60)         
      Amyloid Deposition                                                                                                1 (2%)      
      Congestion                                       2 (3%)                                 1 (2%)                    1 (2%)      
      Developmental Malformation                       2 (3%)                                                                       
      Ectopic Tissue                                                             1 (10%)                                            
      Fibrosis                                                                                             1 (2%)                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Histiocytic                                                                1 (2%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)       1 (2%)                   
      Hypoplasia                                       1 (2%)                                                                       
      Infarct                                                                                 2 (4%)                                
      Inflammation, Suppurative                                                               2 (4%)       2 (4%)                   
      Necrosis, Coagulative                                                                                1 (2%)                   
      Pigmentation, Hemosiderin                        1 (2%)                                              1 (2%)       2 (3%)      
      Thrombosis                                                                                                        1 (2%)      
   Thymus                                             (57)         (3)          (10)         (48)         (48)         (56)         
      Ectopic Tissue                                                                                       1 (2%)                   
      Inflammation, Suppurative                                                               1 (2%)                    1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (54)         (2)          (10)         (46)         (44)         (54)         
      Galactocele                                      2 (4%)                                              2 (5%)                   
   Skin                                               (59)         (4)          (10)         (50)         (51)         (60)         
      Acanthosis                                                                                           1 (2%)                   
      Cyst Epithelial Inclusion                        3 (5%)                    1 (10%)      1 (2%)       2 (4%)                   
      Degeneration                                                                                         1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      25 MG/KG     50 MG/KG     100MG/KG        
                                                   CONTROL      39 KILL      65 KILL                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Hyperkeratosis                                                                                       1 (2%)                   
      Inflammation, Chronic                            2 (3%)                                 3 (6%)                                
      Inflammation, Suppurative                                                               1 (2%)       2 (4%)                   
      Sebaceous Gland, Inflammation, Chronic                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)         (3)          (10)         (50)         (51)         (60)         
      Inflammation, Chronic                                                                                1 (2%)                   
      Necrosis                                         1 (2%)                                                                       
      Cranium, Proliferation                                                                  1 (2%)                                
   Skeletal Muscle                                    (1)                                                 (2)          (1)          
      Inflammation, Chronic                                                                                1 (50%)                  
      Inflammation, Suppurative                                                                            1 (50%)      1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (57)         (20)         (9)          (50)         (49)         (59)         
      Cerebellum, Developmental Malformation           1 (2%)                                                                       
      Hypothalamus, Compression                        1 (2%)                                                                       
      Meninges, Hemorrhage                                                                                              1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                                                                    (1)                                    
      Hemorrhage                                                                              1 (100%)                              
   Lung                                               (59)         (20)         (10)         (49)         (51)         (60)         
      Atelectasis                                                                                          1 (2%)                   
      Congestion                                                    3 (15%)                                                         
      Edema                                                                      2 (20%)                   1 (2%)                   
      Foreign Body                                                                                                      1 (2%)      
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia, Macrophage                                                                 2 (4%)                    1 (2%)      
      Inflammation, Granulomatous                                   2 (10%)                                                         
      Inflammation, Suppurative                        1 (2%)                                 1 (2%)       2 (4%)                   
      Mineralization                                                                          1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 5 (8%)                                 1 (2%)       1 (2%)       1 (2%)      
   Nose                                               (59)         (2)          (10)         (50)         (52)         (60)         
      Congestion                                                    1 (50%)                                                         
      Fungus                                           4 (7%)                                 2 (4%)       4 (8%)       3 (5%)      
      Hemorrhage                                                                              1 (2%)                    1 (2%)      
      Inflammation, Suppurative                       15 (25%)                               20 (40%)     28 (54%)     44 (73%)     
      Metaplasia, Squamous                                                                    1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     VEHICLE      0 MG/KG      0 MG/KG      25 MG/KG     50 MG/KG     100MG/KG        
                                                   CONTROL      39 KILL      65 KILL                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Olfactory Epithelium, Degeneration                                                                                1 (2%)      
      Respiratory Epithelium, Hyperplasia                                                                               1 (2%)      
   Trachea                                            (59)         (3)          (10)         (49)         (50)         (60)         
      Inflammation, Suppurative                                                                            1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                                                    (4)          (1)          
      Cataract                                                                                             1 (25%)      1 (100%)    
      Pigmentation                                                                                         1 (25%)                  
      Cornea, Edema                                                                                        1 (25%)                  
      Retina, Degeneration                                                                                              1 (100%)    
   Zymbal's Gland                                                                            (2)          (1)          (1)          
      Inflammation, Suppurative                                                                            1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (19)         (10)         (60)         (60)         (60)         
      Congestion                                       1 (2%)                                                                       
      Nephropathy                                     58 (98%)     17 (89%)      9 (90%)     58 (97%)     59 (98%)     60 (100%)    
      Cortex, Cyst                                     1 (2%)                                 3 (5%)       2 (3%)       1 (2%)      
      Renal Tubule, Hyperplasia                        1 (2%)                                 3 (5%)                                
   Urinary Bladder                                    (55)         (20)         (10)         (49)         (50)         (59)         
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Suppurative                                                                                         1 (2%)      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     100MG/KG     100MG/KG     100MG/KG     100MG/KG                                  
                                                                 39 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          20           20           10           20                                     
  Scheduled Sacrifice                                 18                        10                                                  
  Early Deaths                                                                                                                      
    Gavage Death                                       2            1                         3                                     
    Moribund                                                        6                        13                                     
    Dead                                                            4                         2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                              8                         2                                     
    Dead                                                            1                                                               
  Animals Examined Microscopically                    20           20           10           20                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (2)          (18)         (10)         (20)                                   
      Inflammation, Suppurative                                                               1 (5%)                                
   Intestine Small, Jejunum                           (2)          (17)         (10)         (20)                                   
      Necrosis, Coagulative                                                                   1 (5%)                                
   Liver                                              (20)         (20)         (10)         (20)                                   
      Basophilic Focus                                              2 (10%)                   1 (5%)                                
      Clear Cell Focus                                 2 (10%)                                                                      
      Developmental Malformation                                    2 (10%)                                                         
      Fatty Change                                                  2 (10%)      9 (90%)      3 (15%)                               
      Fibrosis                                                                                2 (10%)                               
      Hyperplasia                                                   1 (5%)                                                          
      Inflammation, Chronic                            1 (5%)       1 (5%)                                                          
      Inflammation, Chronic, Focal                     1 (5%)                                                                       
      Mixed Cell Focus                                                                        1 (5%)                                
      Necrosis, Coagulative                           11 (55%)      2 (10%)      2 (20%)      3 (15%)                               
      Necrosis, Multifocal                             6 (30%)                                                                      
      Bile Duct, Hyperplasia                          17 (85%)     17 (85%)     10 (100%)    14 (70%)                               
      Hepatocyte, Cytomegaly                          18 (90%)                                                                      
      Hepatocyte, Degeneration, Granular                                         8 (80%)      1 (5%)                                
      Periductular, Fibrosis                                                                  1 (5%)                                
   Mesentery                                          (1)          (7)          (1)          (4)                                    
      Fat, Inflammation, Chronic                                    2 (29%)                                                         
      Fat, Inflammation, Suppurative                                                          1 (25%)                               
      Fat, Necrosis, Coagulative                       1 (100%)     2 (29%)      1 (100%)     3 (75%)                               
   Pancreas                                           (20)         (19)         (10)         (20)                                   
      Atrophy                                                       1 (5%)                    2 (10%)                               
      Hyperplasia                                                   1 (5%)                                                          
      Inflammation, Chronic                                                      1 (10%)                                            
   Stomach, Forestomach                               (20)         (19)         (10)         (19)                                   
      Cyst Epithelial Inclusion                                     1 (5%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     100MG/KG     100MG/KG     100MG/KG     100MG/KG                                  
                                                                 39 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperkeratosis                                                2 (11%)                                                         
      Hyperplasia                                                   1 (5%)                    1 (5%)                                
      Inflammation, Chronic                                         3 (16%)                   3 (16%)                               
      Inflammation, Suppurative                                     1 (5%)                    1 (5%)                                
      Ulcer                                                         3 (16%)                   5 (26%)                               
   Stomach, Glandular                                 (20)         (18)         (10)         (20)                                   
      Dilatation                                                                              1 (5%)                                
      Inflammation, Chronic                                         1 (6%)                                                          
      Mineralization                                                1 (6%)                    2 (10%)                               
      Ulcer                                                                                   2 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                       (1)                                    
      Aorta, Mineralization                                         1 (100%)                  1 (100%)                              
      Mesenteric Artery, Mineralization                             1 (100%)                                                        
   Heart                                              (20)         (20)         (10)         (20)                                   
      Cardiomyopathy                                   9 (45%)     11 (55%)      4 (40%)     10 (50%)                               
      Fibrosis                                                      1 (5%)                                                          
      Thrombosis                                                    1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (20)         (20)         (10)         (20)                                   
      Congestion                                                    1 (5%)                                                          
   Parathyroid Gland                                  (20)         (19)         (10)         (18)                                   
      Hyperplasia                                                   4 (21%)                   8 (44%)                               
   Pituitary Gland                                    (20)         (20)         (10)         (20)                                   
      Pars Distalis, Congestion                                     1 (5%)                                                          
      Pars Distalis, Cyst                                           1 (5%)                                                          
      Pars Distalis, Hyperplasia                                    1 (5%)                                                          
   Thyroid Gland                                      (20)         (20)         (10)         (20)                                   
      Follicular Cell, Cyst                                         1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     100MG/KG     100MG/KG     100MG/KG     100MG/KG                                  
                                                                 39 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (3)          (19)         (10)         (20)                                   
      Dilatation                                                                              1 (5%)                                
      Hemorrhage                                                    1 (5%)                                                          
      Inflammation, Suppurative                                     1 (5%)                    2 (10%)                               
   Prostate                                           (20)         (20)         (10)         (20)                                   
      Hemorrhage                                                                              1 (5%)                                
      Hyperplasia                                                   2 (10%)                   1 (5%)                                
      Inflammation, Chronic                                                                   1 (5%)                                
   Testes                                             (20)         (20)         (10)         (20)                                   
      Atrophy                                                       1 (5%)       1 (10%)      1 (5%)                                
      Infarct                                                                                 1 (5%)                                
      Interstitial Cell, Hyperplasia                  14 (70%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (2)          (19)         (10)         (20)                                   
      Hyperplasia, Mononuclear Cell                                 1 (5%)                                                          
   Lymph Node, Mandibular                             (20)         (20)         (9)          (20)                                   
      Congestion                                                    1 (5%)                                                          
      Hyperplasia, Lymphoid                                                                   1 (5%)                                
   Lymph Node, Mesenteric                             (3)          (20)         (10)         (20)                                   
      Congestion                                                    1 (5%)                                                          
   Spleen                                             (20)         (19)         (10)         (20)                                   
      Developmental Malformation                                    1 (5%)                                                          
      Fibrosis                                                                                1 (5%)                                
      Necrosis                                                                                1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (2)          (20)         (10)         (20)                                   
      Cyst Epithelial Inclusion                                                               1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (20)         (19)         (10)         (20)                                   
      Cerebellum, Hemorrhage                                                                  1 (5%)                                
      Cerebrum, Hemorrhage                                                                    1 (5%)                                
      Cerebrum, Infarct                                                                       1 (5%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05090-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                              COUMARIN                                         Date: 09/12/94  
Route: GAVAGE                                                                                                     Time: 03:12:33  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     100MG/KG     100MG/KG     100MG/KG     100MG/KG                                  
                                                                 39 STOP      65 KILL      65 STOP                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (20)         (20)         (10)         (20)                                   
      Congestion                                       2 (10%)                                                                      
      Emphysema                                                     1 (5%)                                                          
      Fibrosis                                                      1 (5%)                                                          
      Foreign Body                                                                            3 (15%)                               
      Hemorrhage                                       1 (5%)                                 1 (5%)                                
      Inflammation, Suppurative                                                               1 (5%)                                
      Alveolar Epithelium, Hyperplasia                              3 (15%)                   1 (5%)                                
   Nose                                               (2)          (20)         (10)         (20)                                   
      Fungus                                                        1 (5%)                    2 (10%)                               
      Inflammation, Suppurative                                     3 (15%)      1 (10%)      3 (15%)                               
      Metaplasia, Squamous                                                                    1 (5%)                                
      Necrosis, Coagulative                                                                   1 (5%)                                
      Nasolacrimal Duct, Inflammation                  2 (100%)                                                                     
   Trachea                                            (2)          (20)         (10)         (20)                                   
      Metaplasia, Squamous                                                                    1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                       (1)                                    
      Inflammation, Suppurative                                     1 (100%)                                                        
      Posterior Chamber, Hemorrhage                                                           1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (20)         (20)         (10)         (20)                                   
      Hydronephrosis                                                             1 (10%)                                            
      Nephropathy                                     19 (95%)     20 (100%)    10 (100%)    20 (100%)                              
      Cortex, Cyst                                                                            1 (5%)                                
      Renal Tubule, Hyperplasia                                                               3 (15%)                               
   Urinary Bladder                                    (20)         (20)         (10)         (20)                                   
      Calculus Gross Observation                       2 (10%)                                                                      
      Inflammation, Suppurative                                     1 (5%)                                                          
      Lumen, Hemorrhage                                                                       1 (5%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------