TDMS Study 05094-02 Pathology Tables
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
Facility: Southern Research Institute
Chemical CAS #: 85-68-7
Lock Date: 11/25/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD CONTROL 0.6% 1.2% 2.4%
CONTROL FEED RTD
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60 60
Scheduled Sacrifice 10 10 10 10 10
Early Deaths
Moribund Sacrifice 23 7 17 16 20
Natural Death 2 2 4 5 1
Survivors
Terminal Sacrifice 25 41 29 29 29
Animals Examined Microscopically 60 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (60) (59) (58) (59) (60)
Intestine Large, Cecum (59) (60) (60) (59) (59)
Intestine Small, Jejunum (60) (60) (59) (60) (59)
Carcinoma 1 (2%)
Intestine Small, Ileum (59) (59) (60) (60) (60)
Liver (60) (60) (60) (60) (60)
Carcinoma, Metastatic, Intestine Small,
Jejunum 1 (2%)
Hepatocellular Adenoma 2 (3%) 2 (3%)
Mesentery (11) (2) (8) (12) (6)
Leiomyosarcoma, Metastatic, Uterus 1 (8%)
Lipoma 1 (13%)
Liposarcoma 1 (9%)
Schwannoma Malignant 1 (13%)
Oral Mucosa (1) (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%)
Pancreas (60) (59) (60) (60) (60)
Acinus, Adenoma 2 (3%)
Salivary Glands (59) (60) (60) (60) (60)
Stomach, Forestomach (60) (60) (60) (60) (60)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (60) (60) (60) (60) (60)
Tongue (3) (1) (1) (1)
Squamous Cell Papilloma 2 (67%) 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD CONTROL 0.6% 1.2% 2.4%
CONTROL FEED RTD
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60) (60)
Schwannoma Malignant 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60) (60)
Adenoma 1 (2%) 5 (8%) 1 (2%)
Carcinoma 1 (2%) 1 (2%)
Adrenal Medulla (59) (60) (59) (60) (60)
Ganglioneuroma 1 (2%)
Pheochromocytoma Complex 1 (2%)
Pheochromocytoma Benign 1 (2%) 2 (3%) 1 (2%)
Islets, Pancreatic (60) (59) (60) (60) (60)
Adenoma 1 (2%) 1 (2%)
Carcinoma 2 (3%)
Parathyroid Gland (56) (56) (59) (59) (58)
Adenoma 1 (2%)
Pituitary Gland (59) (57) (60) (58) (60)
Pars Distalis, Adenoma 19 (32%) 8 (14%) 27 (45%) 26 (45%) 13 (22%)
Pars Distalis, Adenoma, Multiple 1 (2%)
Pars Distalis, Carcinoma 2 (3%)
Pars Intermedia, Adenoma 1 (2%)
Thyroid Gland (59) (60) (60) (60) (60)
C-Cell, Adenoma 4 (7%) 1 (2%) 5 (8%) 3 (5%) 2 (3%)
C-Cell, Adenoma, Multiple 1 (2%)
C-Cell, Carcinoma 1 (2%) 2 (3%)
C-Cell, Carcinoma, Multiple 1 (2%)
Follicular Cell, Adenoma 1 (2%)
Follicular Cell, Carcinoma 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (60) (60) (60) (60) (60)
Adenoma 3 (5%) 2 (3%) 4 (7%) 4 (7%) 4 (7%)
Carcinoma 4 (7%) 1 (2%) 6 (10%) 5 (8%)
Ovary (60) (60) (60) (60) (60)
Arrhenoblastoma NOS 1 (2%)
Granulosa Cell Tumor Benign 2 (3%)
Uterus (60) (60) (60) (60) (60)
Page 3
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD CONTROL 0.6% 1.2% 2.4%
CONTROL FEED RTD
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Deciduoma Benign 1 (2%) 1 (2%)
Leiomyoma 1 (2%)
Leiomyosarcoma 1 (2%) 1 (2%)
Polyp Stromal 7 (12%) 4 (7%) 10 (17%) 6 (10%) 7 (12%)
Sarcoma Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60) (60)
Lymph Node (12) (13) (12) (17) (16)
Lymph Node, Mandibular (59) (60) (60) (60) (60)
Lymph Node, Mesenteric (60) (60) (60) (60) (60)
Spleen (60) (60) (60) (60) (60)
Thymus (58) (59) (59) (60) (58)
Carcinoma, Metastatic, Thyroid Gland 1 (2%)
Thymoma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (59) (58) (60) (60) (60)
Adenoma 2 (3%)
Carcinoma 2 (3%) 1 (2%) 2 (3%)
Fibroadenoma 28 (47%) 7 (12%) 31 (52%) 32 (53%) 11 (18%)
Skin (60) (60) (60) (60) (60)
Basal Cell Adenoma 1 (2%) 1 (2%)
Basal Cell Carcinoma 1 (2%)
Keratoacanthoma 1 (2%) 1 (2%) 1 (2%)
Squamous Cell Papilloma 1 (2%)
Trichoepithelioma 1 (2%)
Sebaceous Gland, Carcinoma 1 (2%)
Subcutaneous Tissue, Fibroma 1 (2%) 1 (2%) 1 (2%) 2 (3%)
Subcutaneous Tissue, Lipoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60) (60)
Astrocytoma Malignant 1 (2%) 1 (2%)
Carcinoma 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 2 (3%)
Page 4
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD CONTROL 0.6% 1.2% 2.4%
CONTROL FEED RTD
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 2 (3%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60) (60)
Hemangioma 1 (2%)
Renal Tubule, Adenoma 1 (2%)
Renal Tubule, Carcinoma 1 (2%) 1 (2%)
Urinary Bladder (60) (60) (60) (60) (60)
Transitional Epithelium, Papilloma 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60) *(60)
Leukemia Mononuclear 22 (37%) 13 (22%) 20 (33%) 21 (35%) 19 (32%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE UNTREATD CONTROL 0.6% 1.2% 2.4%
CONTROL FEED RTD
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 53 33 52 48 42
Total Primary Neoplasms 117 50 124 116 70
Total Animals with Benign Neoplasms 43 20 47 43 31
Total Benign Neoplasms 81 30 90 80 48
Total Animals with Malignant Neoplasms 31 20 31 28 22
Total Malignant Neoplasms 36 20 34 35 22
Total Animals with Metastatic Neoplasms 2 1 1 1 1
Total Metastatic Neoplasm 2 1 1 1 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1
Total Uncertain Neoplasms 1
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD CONTROL 0.3% 0.6% 1.2%
CONTROL FEED RTD
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60 60 60
Scheduled Sacrifice 10 10 10 10 10
Early Deaths
Moribund Sacrifice 19 15 19 26 26
Natural Death 3 1 11 2 2
Survivors
Terminal Sacrifice 28 33 20 22 22
Other 1
Animals Examined Microscopically 60 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (54) (59) (58) (59) (58)
Adenocarcinoma 1 (2%)
Carcinoid Tumor Malignant 1 (2%)
Intestine Large, Rectum (59) (57) (60) (60) (59)
Leiomyosarcoma 1 (2%)
Intestine Large, Cecum (57) (60) (60) (60) (60)
Lipoma 1 (2%)
Intestine Small, Duodenum (60) (60) (60) (60) (60)
Intestine Small, Jejunum (59) (60) (60) (60) (60)
Leiomyoma 1 (2%)
Intestine Small, Ileum (59) (60) (60) (59) (60)
Leiomyosarcoma 1 (2%)
Liver (60) (60) (60) (60) (60)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (2%)
Carcinoma, Metastatic, Pancreas 1 (2%)
Hepatocellular Carcinoma 1 (2%) 1 (2%)
Hepatocellular Adenoma 2 (3%) 1 (2%) 1 (2%) 4 (7%)
Hepatocellular Adenoma, Multiple 1 (2%)
Mesentery (11) (15) (15) (17) (6)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (6%)
Oral Mucosa (1) (2)
Squamous Cell Papilloma 1 (100%) 2 (100%)
Pancreas (60) (60) (59) (60) (60)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (2%)
Acinus, Adenoma 3 (5%) 2 (3%) 3 (5%) 10 (17%)
Acinus, Carcinoma 1 (2%) 1 (2%)
Salivary Glands (60) (60) (60) (60) (60)
Page 7
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD CONTROL 0.3% 0.6% 1.2%
CONTROL FEED RTD
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont
Schwannoma Malignant 1 (2%)
Stomach, Forestomach (60) (60) (60) (60) (60)
Stomach, Glandular (60) (60) (60) (60) (60)
Carcinoma 1 (2%)
Tongue (1) (1) (1)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60) (60)
Thymoma Malignant, Metastatic, Thymus 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (60) (60) (60) (60) (60)
Carcinoma 1 (2%)
Adrenal Medulla (60) (60) (60) (60) (60)
Pheochromocytoma Malignant 2 (3%) 1 (2%) 2 (3%) 2 (3%)
Pheochromocytoma Benign 7 (12%) 3 (5%) 8 (13%) 10 (17%) 8 (13%)
Pheochromocytoma Benign, Multiple 3 (5%) 2 (3%)
Islets, Pancreatic (60) (60) (59) (60) (60)
Adenoma 5 (8%) 1 (2%) 2 (3%) 4 (7%) 1 (2%)
Pituitary Gland (59) (60) (60) (60) (59)
Pars Distalis, Adenoma 11 (19%) 10 (17%) 13 (22%) 11 (18%) 11 (19%)
Pars Distalis, Adenoma, Multiple 1 (2%) 1 (2%)
Pars Distalis, Carcinoma 1 (2%)
Pars Intermedia, Adenoma 1 (2%) 1 (2%)
Thyroid Gland (60) (60) (60) (60) (60)
C-Cell, Adenoma 5 (8%) 3 (5%) 3 (5%) 3 (5%) 2 (3%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
Follicular Cell, Carcinoma 2 (3%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (60) (60) (60)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (2%)
Preputial Gland (60) (60) (60) (60) (60)
Adenoma 4 (7%) 3 (5%) 3 (5%) 1 (2%)
Page 8
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD CONTROL 0.3% 0.6% 1.2%
CONTROL FEED RTD
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Carcinoma 1 (2%) 3 (5%) 6 (10%) 1 (2%)
Prostate (60) (60) (60) (60) (60)
Seminal Vesicle (60) (60) (60) (60) (60)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (2%)
Testes (60) (60) (60) (60) (60)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (2%)
Bilateral, Interstitial Cell, Adenoma 40 (67%) 45 (75%) 39 (65%) 42 (70%) 42 (70%)
Interstitial Cell, Adenoma 11 (18%) 9 (15%) 12 (20%) 15 (25%) 12 (20%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (60) (60) (60)
Carcinoma, Metastatic, Pancreas 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Lymph Node (25) (14) (22) (32) (20)
Iliac, Leiomyosarcoma, Metastatic, Intestine
Large, Rectum 1 (4%)
Mediastinal, Schwannoma Malignant,
Metastatic, Skin 1 (7%)
Lymph Node, Mandibular (59) (58) (59) (60) (60)
Lymph Node, Mesenteric (60) (60) (60) (60) (60)
Lymph Node, Mediastinal (1)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (100%)
Spleen (60) (60) (60) (60) (60)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (2%)
Fibroma 1 (2%)
Histiocytic Sarcoma 1 (2%)
Liposarcoma 1 (2%)
Thymus (59) (58) (58) (60) (57)
Thymoma Benign 1 (2%) 1 (2%)
Thymoma Malignant 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (55) (58) (58) (57) (58)
Carcinoma 1 (2%)
Fibroadenoma 2 (4%) 3 (5%) 5 (9%) 2 (4%)
Skin (60) (60) (60) (60) (60)
Basal Cell Adenoma 2 (3%) 2 (3%)
Basal Cell Carcinoma 1 (2%) 1 (2%) 1 (2%)
Page 9
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD CONTROL 0.3% 0.6% 1.2%
CONTROL FEED RTD
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Keratoacanthoma 3 (5%) 1 (2%) 2 (3%) 2 (3%) 1 (2%)
Squamous Cell Papilloma 1 (2%) 1 (2%) 1 (2%)
Sebaceous Gland, Adenoma 1 (2%)
Subcutaneous Tissue, Fibroma 5 (8%) 1 (2%) 2 (3%) 5 (8%) 5 (8%)
Subcutaneous Tissue, Lipoma 1 (2%)
Subcutaneous Tissue, Melanoma Malignant 1 (2%)
Subcutaneous Tissue, Schwannoma Benign 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 1 (2%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (60) (60) (60)
Chordoma 1 (2%)
Osteoma 1 (2%)
Osteosarcoma 1 (2%)
Skeletal Muscle (1) (4) (1)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (100%)
Carcinoma, Metastatic, Pancreas 1 (25%)
Fibrosarcoma 1 (25%)
Hemangiosarcoma 1 (100%)
Squamous Cell Carcinoma, Metastatic, Lung 1 (25%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60) (60)
Astrocytoma Malignant 1 (2%) 1 (2%)
Oligodendroglioma Malignant 1 (2%) 2 (3%)
Spinal Cord (2) (1) (2)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60) (60)
Alveolar/Bronchiolar Adenoma 2 (3%)
Alveolar/Bronchiolar Carcinoma 2 (3%) 1 (2%) 1 (2%)
Carcinoma, Metastatic, Pancreas 1 (2%)
Carcinoma, Metastatic, Adrenal Cortex 1 (2%)
Chordoma, Metastatic, Bone 1 (2%)
Pheochromocytoma Malignant, Metastatic,
Adrenal Medulla 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Thymoma Malignant, Metastatic, Thymus 1 (2%)
____________________________________________________________________________________________________________________________________
Page 10
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD CONTROL 0.3% 0.6% 1.2%
CONTROL FEED RTD
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (2)
Carcinoma 2 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60) (60)
Squamous Cell Carcinoma, Metastatic, Lung 1 (2%)
Renal Tubule, Adenoma 1 (2%) 1 (2%) 2 (3%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (60) (60) (60) (60) (60)
Adenocarcinoma, Metastatic, Intestine Large,
Colon 1 (2%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60) *(60) *(60)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 31 (52%) 15 (25%) 29 (48%) 35 (58%) 30 (50%)
Mesothelioma Malignant 1 (2%) 1 (2%) 3 (5%) 3 (5%) 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 11
NTP Experiment-Test: 05094-02 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC BUTYL BENZYL PHTHALATE Date: 04/03/96
Route: DOSED FEED Time: 06:46:23
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE UNTREATD CONTROL 0.3% 0.6% 1.2%
CONTROL FEED RTD
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 58 60 57 59 59
Total Primary Neoplasms 147 118 150 149 147
Total Animals with Benign Neoplasms 54 57 56 58 56
Total Benign Neoplasms 105 86 105 104 102
Total Animals with Malignant Neoplasms 38 28 36 41 38
Total Malignant Neoplasms 42 32 45 45 45
Total Animals with Metastatic Neoplasms 2 4 2 2
Total Metastatic Neoplasm 2 7 12 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 12
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