TDMS Study 05098-01 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
P-NITROPHENOL
NTP Experiment-Test: 05098-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
Facility: Hazleton, Maryland
Chemical CAS #: 100-02-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Moribund Sacrifice 20 27 22 25
Natural Death 5 7 5 7
Accidently Killed 1
Survivors
Terminal Sacrifice 35 26 33 27
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (59) (59) (59) (59)
Amyloid Deposition 2 (3%) 3 (5%) 1 (2%)
Gallbladder (53) (53) (56) (54)
Cyst 1 (2%)
Intestine Large, Cecum (57) (56) (59) (56)
Amyloid Deposition 1 (2%) 1 (2%)
Polyarteritis 1 (2%)
Intestine Large, Colon (56) (56) (58) (57)
Amyloid Deposition 1 (2%) 1 (2%) 1 (2%)
Edema 2 (4%) 3 (5%)
Polyarteritis 1 (2%)
Intestine Large, Rectum (57) (55) (54) (59)
Amyloid Deposition 1 (2%) 1 (2%)
Intestine Small, Duodenum (58) (56) (57) (53)
Amyloid Deposition 24 (41%) 23 (41%) 16 (28%) 19 (36%)
Intestine Small, Ileum (57) (57) (60) (56)
Amyloid Deposition 37 (65%) 45 (79%) 41 (68%) 38 (68%)
Edema 2 (3%)
Hyperplasia, Lymphoid 1 (2%)
Mucosa, Inflammation, Focal 1 (2%)
Intestine Small, Jejunum (55) (54) (56) (55)
Amyloid Deposition 25 (45%) 30 (56%) 20 (36%) 28 (51%)
Liver (60) (60) (60) (60)
Amyloid Deposition 30 (50%) 37 (62%) 27 (45%) 33 (55%)
Angiectasis, Focal 1 (2%) 1 (2%)
Clear Cell Focus 1 (2%)
Hematopoietic Cell Proliferation 2 (3%) 1 (2%) 1 (2%)
Hyperplasia, Focal 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Inflammation, Chronic, Focal 24 (40%) 21 (35%) 24 (40%) 24 (40%)
Necrosis 2 (3%) 1 (2%)
Necrosis, Focal 1 (2%) 2 (3%) 6 (10%) 3 (5%)
Centrilobular, Hypertrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (1) (2) (1)
Hemorrhage, Focal 1 (100%)
Polyarteritis 1 (50%)
Pancreas (60) (57) (60) (60)
Edema 1 (2%)
Focal Cellular Change 2 (3%) 1 (2%) 1 (2%) 3 (5%)
Necrosis, Focal 1 (2%)
Polyarteritis 1 (2%)
Acinus, Amyloid Deposition 2 (3%) 1 (2%) 1 (2%)
Acinus, Hypertrophy, Focal 2 (3%) 1 (2%) 6 (10%) 1 (2%)
Interlobular, Edema 15 (25%) 15 (26%) 14 (23%) 15 (25%)
Salivary Glands (60) (59) (60) (60)
Amyloid Deposition 27 (45%) 29 (49%) 32 (53%) 32 (53%)
Inflammation, Chronic 1 (2%) 1 (2%)
Inflammation, Focal, Suppurative 1 (2%)
Interlobular, Edema 18 (30%) 21 (36%) 8 (13%) 11 (18%)
Stomach, Forestomach (60) (60) (60) (60)
Ulcer 1 (2%)
Submucosa, Inflammation, Subacute 1 (2%)
Stomach, Glandular (60) (59) (60) (60)
Amyloid Deposition 5 (8%) 1 (2%) 3 (5%)
Necrosis 1 (2%)
Epithelium, Vacuolization Cytoplasmic 1 (2%)
Mucosa, Degeneration 2 (3%)
Mucosa, Necrosis, Focal 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60) (60)
Amyloid Deposition 37 (62%) 35 (58%) 33 (55%) 31 (52%)
Fibrosis 1 (2%)
Inflammation, Acute 1 (2%)
Necrosis, Focal 1 (2%)
Polyarteritis 3 (5%) 1 (2%)
Atrium, Inflammation, Suppurative 1 (2%)
Atrium, Thrombosis 6 (10%) 5 (8%) 3 (5%) 3 (5%)
Myocardium, Inflammation, Focal, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (59) (60) (60)
Capsule, Hyperplasia 56 (93%) 54 (92%) 58 (97%) 55 (92%)
Corticomedullary Junction, Amyloid Deposition 37 (62%) 40 (68%) 31 (52%) 33 (55%)
Corticomedullary Junction, Hemorrhage 2 (3%) 1 (2%)
Corticomedullary Junction, Pigmentation 37 (62%) 34 (58%) 38 (63%) 33 (55%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Corticomedullary Junction, Vacuolization
Cytoplasmic 6 (10%) 9 (15%) 5 (8%) 6 (10%)
Adrenal Gland, Cortex (60) (59) (60) (60)
Amyloid Deposition 1 (2%)
Fibrosis, Focal 1 (2%)
Hematopoietic Cell Proliferation 2 (3%)
Hypertrophy, Focal 2 (3%) 1 (2%)
Necrosis 1 (2%)
Adrenal Gland, Medulla (59) (58) (59) (60)
Hyperplasia, Focal 1 (2%) 1 (2%)
Parathyroid Gland (34) (30) (30) (25)
Amyloid Deposition 12 (35%) 14 (47%) 15 (50%) 8 (32%)
Cyst 1 (3%)
Pituitary Gland (54) (56) (54) (56)
Necrosis 1 (2%)
Pars Distalis, Cyst 3 (6%) 2 (4%) 3 (5%)
Pars Distalis, Hyperplasia, Focal 1 (2%) 1 (2%) 3 (6%)
Thyroid Gland (58) (58) (56) (59)
Amyloid Deposition 23 (40%) 26 (45%) 22 (39%) 17 (29%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 1 (2%) 2 (3%) 1 (2%) 2 (3%)
C-Cell, Hyperplasia 1 (2%)
Follicle, Dilatation 8 (14%) 7 (12%) 6 (11%) 10 (17%)
Follicular Cell, Hyperplasia 4 (7%) 8 (14%) 5 (9%) 9 (15%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (1) (1)
Granuloma 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (60) (57) (60) (59)
Abscess 1 (2%) 1 (2%)
Amyloid Deposition 20 (33%) 21 (37%) 27 (45%) 31 (53%)
Atrophy 13 (22%) 14 (25%) 16 (27%) 10 (17%)
Congestion 1 (2%)
Cyst 6 (10%) 10 (18%) 9 (15%) 13 (22%)
Hematocyst 2 (4%) 1 (2%)
Hemorrhage 2 (3%) 3 (5%) 1 (2%) 3 (5%)
Bilateral, Hemorrhage 1 (2%) 1 (2%)
Follicle, Cyst 1 (2%)
Periovarian Tissue, Cyst 13 (22%) 9 (16%) 8 (13%) 12 (20%)
Uterus (60) (58) (60) (59)
Abscess 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Amyloid Deposition 3 (5%) 2 (3%) 1 (2%) 1 (2%)
Angiectasis, Focal 1 (2%)
Congestion 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%)
Cervix, Cyst 1 (2%)
Cervix, Hypertrophy 1 (2%) 1 (2%)
Cervix, Inflammation, Subacute 1 (2%)
Endometrium, Hyperplasia, Cystic 55 (92%) 57 (98%) 58 (97%) 57 (97%)
Myometrium, Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (60) (58) (60)
Calvarium, Myelofibrosis 4 (7%) 2 (3%) 1 (2%)
Sternal, Myelofibrosis 4 (7%) 2 (3%) 7 (12%) 2 (3%)
Lymph Node (60) (60) (60) (60)
Hyperplasia 1 (2%)
Renal, Hyperplasia 1 (2%)
Lymph Node, Mandibular (57) (60) (60) (60)
Hyperplasia, Lymphoid 1 (2%)
Hyperplasia, Plasma Cell 1 (2%) 1 (2%)
Necrosis 1 (2%)
Lymph Node, Mesenteric (60) (57) (59) (58)
Abscess 1 (2%)
Amyloid Deposition 1 (2%) 2 (4%) 3 (5%) 3 (5%)
Granuloma 1 (2%) 1 (2%)
Hyperplasia 1 (2%) 3 (5%)
Hyperplasia, Lymphoid 2 (3%) 1 (2%) 3 (5%)
Lymphocyte, Necrosis 1 (2%)
Spleen (60) (60) (60) (60)
Amyloid Deposition 25 (42%) 23 (38%) 22 (37%) 19 (32%)
Hematopoietic Cell Proliferation 55 (92%) 52 (87%) 56 (93%) 56 (93%)
Hyperplasia, Lymphoid 2 (3%) 2 (3%) 2 (3%)
Pigmentation, Hemosiderin 22 (37%) 27 (45%) 17 (28%) 24 (40%)
Capsule, Hyperplasia, Focal 1 (2%)
Thymus (47) (49) (42) (47)
Amyloid Deposition 1 (2%)
Depletion Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (38) (43) (44) (42)
Hyperplasia 3 (8%) 2 (5%) 2 (5%) 1 (2%)
Hyperplastic Alveolar Nodule 5 (13%) 4 (9%) 1 (2%) 4 (10%)
Inflammation, Chronic 1 (2%)
Lactation 1 (3%)
Duct, Hyperplasia 1 (2%)
Skin (60) (60) (60) (60)
Edema 1 (2%)
Abdominal, Dermis, Inflammation, Chronic 3 (5%) 1 (2%) 1 (2%)
Abdominal, Subcutaneous Tissue, Edema 18 (30%) 27 (45%) 17 (28%) 20 (33%)
Face, Acanthosis 1 (2%)
Forelimb, Ulcer 1 (2%)
Head, Ulcer 1 (2%)
Neck, Ulcer 1 (2%) 1 (2%)
Other, Inflammation, Chronic 1 (2%)
Tail, Abscess 1 (2%)
Thoracic, Acanthosis 1 (2%)
Thoracic, Ventral, Acanthosis 1 (2%)
Thoracic, Ventral, Exudate 1 (2%)
Skin, Control (60) (60) (60) (60)
Exudate 1 (2%)
Hyperkeratosis 1 (2%)
Dermis, Inflammation, Chronic 3 (5%) 2 (3%) 3 (5%)
Subcutaneous Tissue, Edema 8 (13%) 15 (25%) 12 (20%) 9 (15%)
Skin, Site of Application-No Mass (60) (60) (60) (60)
Acanthosis 4 (7%) 1 (2%) 1 (2%)
Exudate, Focal 1 (2%)
Hyperkeratosis 2 (3%) 1 (2%)
Ulcer 3 (5%) 1 (2%)
Dermis, Inflammation, Chronic 11 (18%) 9 (15%) 2 (3%) 7 (12%)
Subcutaneous Tissue, Edema 3 (5%) 9 (15%) 2 (3%) 6 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60) (60)
Hemorrhage, Focal 1 (2%)
Thalamus, Mineralization, Focal 15 (25%) 17 (28%) 9 (15%) 13 (22%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60) (60)
Congestion 2 (3%) 3 (5%) 4 (7%) 2 (3%)
Hemorrhage 2 (3%) 3 (5%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Inflammation, Chronic, Focal 12 (20%) 9 (15%) 14 (23%) 4 (7%)
Alveolar Epithelium, Hyperplasia, Focal 1 (2%) 1 (2%) 1 (2%)
Alveolus, Infiltration Cellular, Focal,
Histiocyte 4 (7%) 2 (3%) 2 (3%) 6 (10%)
Artery, Amyloid Deposition 1 (2%)
Interstitium, Inflammation, Chronic 5 (8%) 5 (8%) 1 (2%) 7 (12%)
Nose (60) (59) (60) (60)
Exudate 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Suppurative 1 (2%)
Glands, Hyperplasia, Focal 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 1 (2%)
Septum, Amyloid Deposition 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2)
Bilateral, Ulcer 1 (50%)
Eye (1) (1)
Anterior Chamber, Hemorrhage 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Abscess 1 (2%)
Amyloid Deposition 39 (65%) 45 (75%) 42 (70%) 41 (68%)
Hydronephrosis 1 (2%) 1 (2%)
Hypertrophy 1 (2%)
Infarct 1 (2%) 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
Inflammation, Suppurative 1 (2%)
Metaplasia, Osseous 1 (2%)
Nephropathy 5 (8%) 4 (7%) 2 (3%) 5 (8%)
Capsule, Inflammation, Focal 1 (2%)
Cortex, Atrophy 1 (2%)
Cortex, Atrophy, Focal 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Cortex, Cyst 3 (5%) 2 (3%) 1 (2%)
Cortex, Renal Tubule, Mineralization, Focal 1 (2%)
Pelvis, Dilatation 1 (2%) 2 (3%) 3 (5%)
Proximal Convoluted Renal Tubule,
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE FEMALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VF LF MF HF
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Degeneration, Hyaline 1 (2%)
Urethra (1)
Bulbourethral Gland, Dilatation 1 (100%)
Urinary Bladder (57) (54) (56) (57)
Amyloid Deposition 5 (9%) 1 (2%) 1 (2%) 1 (2%)
Infiltration Cellular, Focal, Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 60 60 60
Early Deaths
Accidently Killed 4 1 3
Moribund Sacrifice 22 34 23 21
Natural Death 5 8 11 12
Survivors
Moribund Sacrifice 1 1
Terminal Sacrifice 28 17 26 23
Animals Examined Microscopically 60 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (60) (57) (60) (59)
Amyloid Deposition 1 (2%) 1 (2%) 1 (2%)
Gallbladder (51) (47) (50) (48)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%)
Intestine Large, Cecum (55) (53) (50) (54)
Amyloid Deposition 2 (4%) 1 (2%)
Edema 1 (2%) 1 (2%)
Intestine Large, Colon (55) (54) (53) (54)
Amyloid Deposition 1 (2%) 1 (2%)
Edema 1 (2%) 7 (13%) 4 (8%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Polyarteritis 1 (2%) 2 (4%)
Intestine Large, Rectum (54) (51) (51) (53)
Amyloid Deposition 2 (4%) 1 (2%)
Intestine Small (60) (59) (59) (59)
Mucosa, Abscess 1 (2%)
Intestine Small, Duodenum (57) (54) (50) (49)
Amyloid Deposition 27 (47%) 19 (35%) 12 (24%) 12 (24%)
Intussusception 1 (2%)
Intestine Small, Ileum (56) (55) (53) (55)
Amyloid Deposition 37 (66%) 40 (73%) 36 (68%) 39 (71%)
Edema 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Necrosis 1 (2%)
Intestine Small, Jejunum (56) (51) (51) (51)
Amyloid Deposition 30 (54%) 32 (63%) 28 (55%) 23 (45%)
Liver (60) (59) (60) (60)
Amyloid Deposition 34 (57%) 41 (69%) 31 (52%) 34 (57%)
Degeneration, Fatty 1 (2%)
Granuloma 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hematopoietic Cell Proliferation 2 (3%) 2 (3%) 2 (3%)
Inflammation, Chronic, Focal 18 (30%) 12 (20%) 17 (28%) 17 (28%)
Mitotic Alteration 1 (2%) 1 (2%)
Necrosis 1 (2%)
Necrosis, Focal 2 (3%) 1 (2%) 1 (2%) 4 (7%)
Pigmentation 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Centrilobular, Hypertrophy 2 (3%) 2 (3%)
Mesentery (2) (2) (1)
Granuloma 1 (50%)
Polyarteritis 1 (50%) 1 (100%)
Fat, Necrosis, Focal 1 (50%)
Pancreas (60) (58) (60) (60)
Amyloid Deposition, Focal 1 (2%)
Focal Cellular Change 2 (3%) 1 (2%) 2 (3%)
Inflammation, Focal, Suppurative 1 (2%)
Polyarteritis 1 (2%) 1 (2%)
Acinus, Amyloid Deposition 1 (2%) 1 (2%) 3 (5%) 1 (2%)
Acinus, Hyperplasia, Focal 1 (2%)
Acinus, Hypertrophy, Focal 1 (2%) 2 (3%)
Duct, Cyst 1 (2%)
Interlobular, Edema 17 (28%) 23 (40%) 11 (18%) 14 (23%)
Salivary Glands (60) (58) (60) (60)
Amyloid Deposition 29 (48%) 39 (67%) 33 (55%) 29 (48%)
Infarct 1 (2%)
Inflammation, Chronic 1 (2%)
Inflammation, Focal, Suppurative 1 (2%) 1 (2%)
Interlobular, Edema 11 (18%) 14 (24%) 9 (15%) 10 (17%)
Stomach (60) (59) (60) (60)
Pylorus, Amyloid Deposition 1 (2%)
Submucosa, Edema 2 (3%) 1 (2%)
Stomach, Forestomach (59) (58) (60) (60)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 1 (2%)
Stomach, Glandular (59) (58) (59) (60)
Acanthosis 1 (2%)
Amyloid Deposition 1 (2%) 5 (9%) 4 (7%) 1 (2%)
Submucosa, Inflammation, Acute 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1) (1) (2) (2)
Polyarteritis 1 (100%) 1 (50%)
Aorta, Inflammation, Chronic 1 (50%) 1 (50%)
Aorta, Thrombosis 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Heart (60) (60) (59) (60)
Amyloid Deposition 35 (58%) 41 (68%) 34 (58%) 34 (57%)
Fibrosis 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Necrosis, Focal 2 (3%) 1 (2%)
Polyarteritis 2 (3%) 1 (2%)
Atrium, Thrombosis 10 (17%) 16 (27%) 9 (15%) 4 (7%)
Pericardium, Inflammation, Focal, Subacute 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (58) (60) (60)
Capsule, Hyperplasia 44 (73%) 37 (64%) 40 (67%) 39 (65%)
Corticomedullary Junction, Amyloid Deposition 37 (62%) 39 (67%) 32 (53%) 30 (50%)
Corticomedullary Junction, Mineralization,
Focal 1 (2%)
Corticomedullary Junction, Pigmentation 33 (55%) 28 (48%) 35 (58%) 35 (58%)
Extra Adrenal Tissue, Hemorrhage 1 (2%)
Adrenal Gland, Cortex (60) (58) (59) (59)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Focal 3 (5%) 1 (2%) 1 (2%)
Hypertrophy, Focal 1 (2%) 2 (3%) 1 (2%)
Hypoplasia 2 (3%) 1 (2%)
Necrosis 1 (2%) 1 (2%)
Parathyroid Gland (24) (25) (26) (30)
Amyloid Deposition 12 (50%) 13 (52%) 6 (23%) 8 (27%)
Pituitary Gland (54) (54) (50) (52)
Pars Distalis, Cyst 3 (6%) 3 (6%) 3 (6%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 1 (2%)
Thyroid Gland (60) (56) (57) (59)
Amyloid Deposition 33 (55%) 30 (54%) 24 (42%) 20 (34%)
Inflammation, Chronic 2 (4%) 1 (2%) 1 (2%)
C-Cell, Hyperplasia 1 (2%) 1 (2%) 2 (3%)
Follicle, Dilatation 11 (18%) 7 (13%) 11 (19%) 11 (19%)
Follicular Cell, Hyperplasia 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (2) (2) (3)
Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (1) (1)
Dilatation 1 (100%) 1 (100%)
Epididymis (60) (58) (60) (59)
Edema 1 (2%) 1 (2%)
Granuloma Sperm 1 (2%) 1 (2%)
Inflammation, Chronic 1 (2%) 3 (5%) 2 (3%) 1 (2%)
Necrosis 1 (2%)
Fat, Inflammation, Focal, Suppurative 1 (2%)
Fat, Necrosis 1 (2%)
Penis (3) (2) (4) (2)
Inflammation, Acute 1 (50%)
Preputial Gland (2) (1)
Abscess 1 (50%) 1 (100%)
Cyst 1 (50%)
Prostate (56) (54) (54) (47)
Hyperplasia, Focal 2 (4%)
Inflammation, Chronic 2 (4%) 3 (6%) 1 (2%)
Inflammation, Suppurative 3 (6%)
Seminal Vesicle (60) (57) (60) (60)
Abscess 1 (2%)
Concretion 1 (2%) 1 (2%)
Dilatation 6 (10%) 6 (11%) 3 (5%) 4 (7%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%) 5 (9%) 1 (2%)
Testes (59) (58) (59) (59)
Cyst 1 (2%)
Granuloma Sperm 1 (2%) 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Seminiferous Tubule, Atrophy 3 (5%) 8 (14%) 7 (12%) 9 (15%)
Seminiferous Tubule, Degeneration 3 (5%) 1 (2%) 3 (5%) 1 (2%)
Seminiferous Tubule, Mineralization 1 (2%) 2 (3%) 1 (2%)
Seminiferous Tubule, Necrosis 1 (2%)
Tunic, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (58) (59) (59)
Calvarium, Myelofibrosis 1 (2%)
Lymph Node (60) (59) (60) (60)
Mediastinal, Hyperplasia 1 (2%)
Mediastinal, Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mandibular (56) (57) (60) (60)
Amyloid Deposition 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia, Plasma Cell 2 (4%) 2 (4%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Mesenteric (57) (58) (60) (58)
Abscess 1 (2%) 1 (2%)
Amyloid Deposition 4 (7%) 5 (9%) 6 (10%) 6 (10%)
Granuloma 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 2 (3%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Hyperplasia, Plasma Cell 1 (2%)
Polyarteritis 1 (2%)
Spleen (60) (58) (60) (60)
Amyloid Deposition 30 (50%) 33 (57%) 23 (38%) 28 (47%)
Hematopoietic Cell Proliferation 46 (77%) 49 (84%) 48 (80%) 50 (83%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%) 1 (2%)
Pigmentation, Hemosiderin 8 (13%) 9 (16%) 9 (15%) 11 (18%)
Thymus (46) (45) (43) (40)
Abscess 1 (2%)
Amyloid Deposition 1 (2%)
Cyst 1 (3%)
Depletion Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (60) (60) (60) (60)
Acanthosis 1 (2%)
Edema 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Exudate, Focal 1 (2%)
Abdominal, Edema 1 (2%)
Abdominal, Inflammation, Chronic 1 (2%)
Abdominal, Dermis, Inflammation, Chronic 1 (2%)
Abdominal, Subcutaneous Tissue, Edema 17 (28%) 24 (40%) 16 (27%) 18 (30%)
Face, Acanthosis 1 (2%)
Face, Exudate 1 (2%)
Face, Ulcer 1 (2%)
Foot, Ulcer 1 (2%)
Forelimb, Right, Ulcer 1 (2%)
Head, Ulcer 1 (2%)
Head, Ventral, Ulcer 1 (2%)
Neck, Acanthosis 1 (2%)
Neck, Fungus 1 (2%)
Neck, Inflammation, Subacute 1 (2%)
Neck, Ulcer 1 (2%) 2 (3%)
Neck, Subcutaneous Tissue, Hemorrhage 1 (2%)
Other, Inflammation, Chronic 2 (3%)
Other, Ulcer 2 (3%)
Subcutaneous Tissue, Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Subcutaneous Tissue, Other, Abscess 1 (2%)
Tail, Inflammation, Chronic 1 (2%)
Skin, Control (60) (60) (60) (60)
Dermis, Inflammation, Chronic 2 (3%) 1 (2%) 3 (5%)
Subcutaneous Tissue, Edema 7 (12%) 17 (28%) 9 (15%) 6 (10%)
Subcutaneous Tissue, Hemorrhage 1 (2%)
Skin, Site of Application-No Mass (60) (60) (60) (60)
Acanthosis 1 (2%) 3 (5%) 3 (5%) 1 (2%)
Exudate 2 (3%)
Hyperkeratosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Ulcer 1 (2%) 3 (5%)
Dermis, Inflammation, Chronic 5 (8%) 4 (7%) 3 (5%)
Subcutaneous Tissue, Edema 6 (10%) 8 (13%) 5 (8%) 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (60) (60) (59) (60)
Sternum, Hyperostosis 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (59) (60) (60)
Hydrocephalus 1 (2%)
Perivascular, Infiltration Cellular,
Lymphocyte 1 (2%)
Thalamus, Mineralization, Focal 19 (32%) 11 (19%) 16 (27%) 13 (22%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (58) (60) (60)
Amyloid Deposition, Focal 2 (3%)
Congestion 2 (3%) 5 (9%) 4 (7%) 9 (15%)
Foreign Body 1 (2%)
Hemorrhage 2 (3%) 2 (3%) 1 (2%) 4 (7%)
Inflammation, Chronic, Focal 13 (22%) 9 (16%) 13 (22%) 8 (13%)
Inflammation, Focal, Subacute 1 (2%)
Alveolar Epithelium, Hyperplasia, Focal 5 (8%) 1 (2%) 2 (3%) 2 (3%)
Alveolus, Infiltration Cellular, Focal,
Histiocyte 6 (10%) 5 (9%) 6 (10%) 6 (10%)
Artery, Amyloid Deposition 4 (7%) 1 (2%) 1 (2%)
Interstitium, Inflammation, Chronic 4 (7%) 15 (26%) 6 (10%) 12 (20%)
Vein, Embolus 1 (2%)
Nose (60) (58) (60) (60)
Exudate 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Foreign Body 4 (7%) 2 (3%) 1 (2%) 1 (2%)
Fungus 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%)
Nasolacrimal Duct, Hemorrhage 1 (2%)
Nasolacrimal Duct, Hyperplasia 1 (2%)
Septum, Amyloid Deposition 1 (2%) 1 (2%)
Sinus, Inflammation, Chronic 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (3) (4) (4)
Ulcer 1 (100%) 1 (33%) 2 (50%) 3 (75%)
Bilateral, Ulcer 2 (67%) 1 (25%)
External Ear, Acanthosis 1 (33%)
Pinna, Inflammation, Chronic 1 (25%)
Eye (3) (2) (1) (3)
Cataract 1 (33%) 1 (33%)
Lids, Inflammation, Chronic 1 (33%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60) (60)
Amyloid Deposition 44 (73%) 44 (73%) 41 (68%) 40 (67%)
Atrophy, Diffuse 1 (2%)
Hemorrhage 1 (2%)
Hydronephrosis 1 (2%) 1 (2%)
Infarct 1 (2%)
Inflammation, Chronic, Focal 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 3 (5%)
Nephropathy 7 (12%) 4 (7%) 6 (10%) 5 (8%)
Cortex, Atrophy, Focal 4 (7%) 3 (5%) 2 (3%)
Cortex, Cyst 6 (10%) 9 (15%) 7 (12%) 7 (12%)
Cortex, Renal Tubule, Mineralization, Focal 4 (7%) 2 (3%) 1 (2%) 1 (2%)
Pelvis, Dilatation 2 (3%) 4 (7%) 4 (7%) 2 (3%)
Perirenal Tissue, Hemorrhage 1 (2%)
Urethra (2) (1) (3) (2)
Bulbourethral Gland, Dilatation 2 (100%) 1 (100%) 2 (67%) 2 (100%)
Urinary Bladder (57) (55) (57) (59)
Amyloid Deposition 2 (4%) 1 (2%) 3 (5%) 2 (3%)
Crystals 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Suppurative 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05098-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC P-NITROPHENOL Date: 09/13/94
Route: DERMAL,SOLUTION Time: 11:02:37
____________________________________________________________________________________________________________________________________
SWISS WEBSTER MICE MALE 0MG/KG 40MG/KG 80MG/KG 160MG/KG
VM LM MM HM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Mucosa, Hyperplasia 2 (4%) 1 (2%) 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------