National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2272

TDMS Study 05132-06 Pathology Tables

NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16




       Facility:  Battelle Northwest

       Chemical CAS #:  116-14-3

       Lock Date:  10/14/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          58           58           58           58                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4           16           15           17                                     
    Moribund Sacrifice                                 8           28           26           27                                     
    Accidently Killed                                                            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36            4            6            4                                     

  Animals Examined Microscopically                    58           58           58           58                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (57)         (55)         (52)         (50)                                   
      Sarcoma                                                       1 (2%)                                                          
   Intestine Large, Cecum                             (57)         (52)         (50)         (46)                                   
      Leiomyosarcoma                                   1 (2%)                                                                       
      Sarcoma                                                       1 (2%)                                                          
   Intestine Small, Duodenum                          (55)         (49)         (49)         (45)                                   
      Sarcoma                                                       1 (2%)                                                          
   Intestine Small, Jejunum                           (56)         (47)         (49)         (45)                                   
   Intestine Small, Ileum                             (56)         (49)         (49)         (45)                                   
      Leiomyosarcoma, Metastatic, Uterus                            1 (2%)                                                          
      Sarcoma                                                       1 (2%)                                                          
   Liver                                              (58)         (58)         (57)         (57)                                   
      Hemangioma                                                    4 (7%)       1 (2%)       1 (2%)                                
      Hemangioma, Multiple                                          1 (2%)       1 (2%)                                             
      Hemangiosarcoma                                              20 (34%)     15 (26%)     19 (33%)                               
      Hemangiosarcoma, Multiple                                     8 (14%)     12 (21%)     15 (26%)                               
      Hepatocellular Carcinoma                         4 (7%)      26 (45%)     16 (28%)     16 (28%)                               
      Hepatocellular Carcinoma, Multiple                            5 (9%)       7 (12%)      7 (12%)                               
      Hepatocellular Adenoma                          14 (24%)     12 (21%)     14 (25%)      9 (16%)                               
      Hepatocellular Adenoma, Multiple                 1 (2%)       7 (12%)      9 (16%)      8 (14%)                               
      Histiocytic Sarcoma                              1 (2%)      21 (36%)     19 (33%)     18 (32%)                               
      Sarcoma                                                       1 (2%)                                                          
   Mesentery                                          (10)         (14)         (7)          (7)                                    
      Hemangiosarcoma                                               2 (14%)                                                         
      Histiocytic Sarcoma                              1 (10%)      1 (7%)                                                          
      Leiomyosarcoma, Metastatic, Uterus                            1 (7%)                                                          
      Sarcoma                                                       1 (7%)                    1 (14%)                               
   Pancreas                                           (58)         (57)         (54)         (57)                                   
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                           2 (4%)       1 (2%)       1 (2%)                                

                                                             Page   2                                                               
NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Leiomyosarcoma, Metastatic, Uterus                            1 (2%)                                                          
      Sarcoma                                                       1 (2%)                                                          
   Stomach, Forestomach                               (58)         (58)         (57)         (57)                                   
      Leiomyosarcoma, Metastatic, Uterus                            1 (2%)                                                          
      Squamous Cell Papilloma                                       1 (2%)       1 (2%)                                             
   Stomach, Glandular                                 (58)         (58)         (55)         (55)                                   
      Leiomyosarcoma, Metastatic, Uterus                            1 (2%)                                                          
      Sarcoma                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)         (58)         (57)         (58)                                   
      Histiocytic Sarcoma                                                        1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (57)         (57)         (57)                                   
      Adenoma                                                       1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)       3 (5%)                    1 (2%)                                
      Capsule, Adenoma                                 1 (2%)                                                                       
      Capsule, Carcinoma                               1 (2%)                                                                       
   Adrenal Medulla                                    (58)         (57)         (57)         (56)                                   
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (58)         (55)         (54)         (57)                                   
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (56)         (55)         (54)         (56)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Pars Distalis, Adenoma                           4 (7%)       5 (9%)       2 (4%)       6 (11%)                               
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (58)         (58)         (56)         (56)                                   
      Follicular Cell, Adenoma                         3 (5%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (57)         (57)         (55)         (56)                                   
      Cystadenoma                                      2 (4%)                                 2 (4%)                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)       5 (9%)       4 (7%)       3 (5%)                                

                                                             Page   3                                                               
NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Luteoma                                          2 (4%)                                                                       
      Sarcoma                                                       1 (2%)                                                          
      Periovarian Tissue, Histiocytic Sarcoma                                    1 (2%)                                             
   Uterus                                             (58)         (58)         (55)         (57)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leiomyosarcoma                                                1 (2%)                                                          
      Polyp Stromal                                    1 (2%)                                 1 (2%)                                
      Cervix, Granular Cell Tumor NOS                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)         (58)         (56)         (57)                                   
      Histiocytic Sarcoma                                           6 (10%)      5 (9%)       4 (7%)                                
   Lymph Node                                         (5)          (6)          (5)          (6)                                    
      Axillary, Histiocytic Sarcoma                    1 (20%)                                                                      
      Iliac, Histiocytic Sarcoma                       1 (20%)      1 (17%)      1 (20%)      1 (17%)                               
      Pancreatic, Histiocytic Sarcoma                                            1 (20%)      1 (17%)                               
      Renal, Histiocytic Sarcoma                                    1 (17%)      2 (40%)      2 (33%)                               
   Lymph Node, Bronchial                              (47)         (44)         (49)         (46)                                   
      Histiocytic Sarcoma                                           4 (9%)       6 (12%)      4 (9%)                                
      Sarcoma                                                       1 (2%)                                                          
   Lymph Node, Mandibular                             (46)         (39)         (43)         (38)                                   
      Histiocytic Sarcoma                              1 (2%)       3 (8%)       2 (5%)       2 (5%)                                
   Lymph Node, Mesenteric                             (53)         (50)         (51)         (53)                                   
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       6 (12%)      7 (14%)      6 (11%)                               
   Lymph Node, Mediastinal                            (35)         (42)         (43)         (36)                                   
      Histiocytic Sarcoma                              1 (3%)       9 (21%)      9 (21%)      4 (11%)                               
   Spleen                                             (58)         (58)         (56)         (57)                                   
      Histiocytic Sarcoma                              1 (2%)       7 (12%)      8 (14%)      9 (16%)                               
      Sarcoma                                                       1 (2%)                                                          
   Thymus                                             (56)         (52)         (49)         (48)                                   
      Histiocytic Sarcoma                                           2 (4%)       2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (56)         (54)         (56)                                   
      Carcinoma                                        1 (2%)                                                                       
   Skin                                               (57)         (58)         (57)         (58)                                   
      Hemangioma                                                                 1 (2%)                                             
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                                            2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)         (58)         (57)         (58)                                   
      Osteosarcoma                                     1 (2%)                                                                       
      Rib, Leiomyosarcoma, Metastatic, Uterus                       1 (2%)                                                          
   Skeletal Muscle                                                 (1)                                                              
      Leiomyosarcoma, Metastatic, Uterus                            1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (58)         (56)         (58)                                   
      Astrocytoma NOS                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (58)         (58)         (57)         (57)                                   
      Alveolar/Bronchiolar Adenoma                     5 (9%)                    6 (11%)      3 (5%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                             2 (4%)       1 (2%)                                
      Carcinoma                                                     1 (2%)                                                          
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Liver                                                      3 (5%)                                
      Hemangiosarcoma, Metastatic, Pancreas                                                   1 (2%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      1 (2%)       8 (14%)      6 (11%)      5 (9%)                                
      Histiocytic Sarcoma                              1 (2%)      16 (28%)     13 (23%)     13 (23%)                               
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Sarcoma                                                       1 (2%)                                                          
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (6)          (4)          (8)                                    
      Adenoma                                          3 (75%)      3 (50%)                   7 (88%)                               
      Bilateral, Adenoma                                                                      1 (13%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (58)         (57)         (57)                                   
      Histiocytic Sarcoma                              1 (2%)       7 (12%)      4 (7%)       3 (5%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
   Urinary Bladder                                    (55)         (53)         (53)         (46)                                   
      Leiomyosarcoma, Metastatic, Uterus                            1 (2%)                                                          

                                                             Page   5                                                               
NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Sarcoma                                                       1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(58)        *(58)        *(58)        *(58)                                   
      Histiocytic Sarcoma                              1 (2%)      21 (36%)     19 (33%)     18 (31%)                               
      Lymphoma Malignant Lymphocytic                                1 (2%)                                                          
      Lymphoma Malignant Mixed                         5 (9%)       2 (3%)                    3 (5%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   6                                                               
NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          53          50          52                                       
     Total Primary Neoplasms                           56         139         109         123                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 29          27          30          33                                       
     Total Benign Neoplasms                            40          37          38          40                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              14          49          46          50                                       
     Total Malignant Neoplasms                         14         102          71          83                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           9           6          10                                       
     Total Metastatic Neoplasm                          4          16           6          10                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  2                                                                           
     Total Uncertain Neoplasms                          2                                                                           
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          58           58           58           58                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Natural Death                                      4           13           20           20                                     
    Moribund Sacrifice                                 6           24           26           27                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                38           11            2            1                                     

  Animals Examined Microscopically                    58           58           58           58                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (58)         (58)         (58)         (58)                                   
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
      Carcinoma, Metastatic, Lung                                   1 (2%)                                                          
      Hemangioma                                                    3 (5%)       3 (5%)       1 (2%)                                
      Hemangioma, Multiple                                          7 (12%)      2 (3%)       1 (2%)                                
      Hemangiosarcoma                                               5 (9%)      10 (17%)     22 (38%)                               
      Hemangiosarcoma, Multiple                                    16 (28%)     17 (29%)     18 (31%)                               
      Hepatocellular Carcinoma                         9 (16%)     15 (26%)     26 (45%)     22 (38%)                               
      Hepatocellular Carcinoma, Multiple               4 (7%)       9 (16%)      9 (16%)      6 (10%)                               
      Hepatocellular Adenoma                          16 (28%)     13 (22%)      7 (12%)     14 (24%)                               
      Hepatocellular Adenoma, Multiple                 7 (12%)      6 (10%)      9 (16%)      7 (12%)                               
      Histiocytic Sarcoma                                          12 (21%)      7 (12%)      8 (14%)                               
   Mesentery                                          (2)          (3)          (2)          (7)                                    
      Carcinoma, Metastatic, Lung                                   1 (33%)                                                         
      Hemangioma                                                                              1 (14%)                               
      Hemangiosarcoma                                                                         1 (14%)                               
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (14%)                               
      Histiocytic Sarcoma                                                        1 (50%)                                            
   Pancreas                                           (58)         (58)         (56)         (55)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
   Stomach, Forestomach                               (58)         (58)         (56)         (56)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                          2 (3%)       1 (2%)       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)         (58)         (58)         (58)                                   
      Carcinoma, Metastatic, Lung                                   1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (58)         (57)         (58)                                   
      Adenoma                                          1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (58)         (58)         (56)         (55)                                   
      Adenoma                                                                                 1 (2%)                                
   Thyroid Gland                                      (58)         (58)         (57)         (57)                                   
      Follicular Cell, Adenoma                                      3 (5%)                                                          
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)          (2)                                                 
      Carcinoma, Metastatic, Lung                                   1 (50%)                                                         
      Hemangioma                                                    1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (58)         (58)         (58)         (58)                                   
      Leiomyoma                                                                               1 (2%)                                
      Leiomyosarcoma                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (58)         (58)         (57)         (57)                                   
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)       2 (4%)                                
   Lymph Node                                         (3)          (1)          (2)                                                 
      Renal, Histiocytic Sarcoma                                    1 (100%)     1 (50%)                                            
   Lymph Node, Bronchial                              (42)         (42)         (43)         (33)                                   
      Histiocytic Sarcoma                                           3 (7%)                    1 (3%)                                
   Lymph Node, Mandibular                             (44)         (37)         (38)         (42)                                   
      Histiocytic Sarcoma                                           2 (5%)       1 (3%)                                             
   Lymph Node, Mesenteric                             (57)         (52)         (51)         (50)                                   
      Histiocytic Sarcoma                                           4 (8%)       1 (2%)       2 (4%)                                
   Lymph Node, Mediastinal                            (37)         (39)         (40)         (36)                                   
      Carcinoma, Metastatic, Lung                                   1 (3%)                    1 (3%)                                
      Histiocytic Sarcoma                                           2 (5%)                    1 (3%)                                
   Spleen                                             (58)         (58)         (56)         (56)                                   
      Hemangiosarcoma                                  2 (3%)                                                                       
      Histiocytic Sarcoma                                           2 (3%)       1 (2%)       2 (4%)                                
   Thymus                                             (51)         (49)         (44)         (46)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Thymoma NOS                                                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________

                                                             Page   9                                                               
NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (58)         (57)         (58)         (58)                                   
      Subcutaneous Tissue, Hemangioma                               1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma                                       1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (58)         (58)         (58)         (58)                                   
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
   Skeletal Muscle                                                                           (1)                                    
      Carcinoma, Metastatic, Lung                                                             1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (58)         (58)         (58)                                   
      Carcinoma, Metastatic, Harderian Gland                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (58)         (58)         (58)         (58)                                   
      Alveolar/Bronchiolar Adenoma                    10 (17%)      7 (12%)     12 (21%)      4 (7%)                                
      Alveolar/Bronchiolar Adenoma, Multiple           1 (2%)       1 (2%)       1 (2%)       2 (3%)                                
      Alveolar/Bronchiolar Carcinoma                   2 (3%)       4 (7%)       3 (5%)       1 (2%)                                
      Carcinoma                                                     1 (2%)                    1 (2%)                                
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                 1 (2%)                                
      Hemangiosarcoma, Metastatic, Liver                                         2 (3%)       2 (3%)                                
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)       7 (12%)     15 (26%)      8 (14%)                               
      Histiocytic Sarcoma                                           7 (12%)      4 (7%)       4 (7%)                                
   Nose                                               (58)         (57)         (56)         (57)                                   
      Carcinoma, Metastatic, Harderian Gland           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (7)          (10)         (5)          (7)                                    
      Adenoma                                          6 (86%)      9 (90%)      4 (80%)      5 (71%)                               
      Carcinoma                                        1 (14%)      1 (10%)                   1 (14%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  10                                                               
NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (58)         (58)         (58)                                   
      Carcinoma, Metastatic, Lung                                                             1 (2%)                                
      Hemangiosarcoma, Metastatic, Liver                                         1 (2%)                                             
      Histiocytic Sarcoma                                           3 (5%)       3 (5%)       2 (3%)                                
   Urinary Bladder                                    (58)         (53)         (53)         (52)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(58)        *(58)        *(58)        *(58)                                   
      Histiocytic Sarcoma                                          12 (21%)      7 (12%)      8 (14%)                               
      Lymphoma Malignant Mixed                         2 (3%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  11                                                               
NTP Experiment-Test: 05132-06  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                        TETRAFLUOROETHYLENE                                    Date: 04/04/96  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 01:15:16  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      312 PPM      625 PPM      1250 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            43          51          54          52                                       
     Total Primary Neoplasms                           63         119         114         121                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 32          34          31          30                                       
     Total Benign Neoplasms                            43          52          41          38                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              18          43          49          50                                       
     Total Malignant Neoplasms                         20          66          73          83                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           8          15          11                                       
     Total Metastatic Neoplasm                          4          12          18          20                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  12                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.