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TDMS Study 05132-06 Pathology Tables

                                              NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL
                                                     TETRAFLUOROETHYLENE  (TFE)


NTP Experiment-Test: 05132-06                                                                                     Report: PEIRPT09
Study Type: CHRONIC                                                                                               Date: 09/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30


                                                           CORE STUDY


       Facility:  Battelle Northwest

       Chemical CAS #:  116-14-3

       Lock Date:  10/14/92

       Cage Range:  All

       Reasons For Removal:    25008 Accident                          25022 Accidently Killed
                               25003 Moribund                          25019 Moribund Sacrifice
                               25020 Natural Death                     25006 Terminal Sacrifice
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include 002    CONTROL
                               Include 004    312 PPM
                               Include 006    625 PPM
                               Include 008    1250 PPM
                               Include 001    CONTROL
                               Include 003    312 PPM
                               Include 005    625 PPM
                               Include 007    1250 PPM























                                                             Page   1
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|             
                             DAY ON TEST   | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|             
                                           | 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  I  +  +  M  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |    3                                                                     |             
      Mesothelium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mesothelium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +|             
      Mesothelium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                               4                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Perforation                          |                                                                          |             
      Mesothelium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Mesothelium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                         1|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
      Clear Cell Focus                     |                                                                   X      |             
      Eosinophilic Focus                   | X           X        X     X                                             |             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Infarct                              |          4                          3                                    |             
      Infiltration Cellular, Mixed Cell    |                   1           1                    3           1         |             
      Inflammation, Suppurative            |                                                                         3|             
      Mixed Cell Focus                     |                         X                                                |             
      Necrosis, Coagulative, Multifocal    |                                                             1        1   |             
      Serosa, Fibrosis                     |                                                                         3|             
                                            __________________________________________________________________________|             
   Mesentery                               |       +           +  +                          +                       +|             
      Angiectasis                          |                                                                          |             
      Fat, Necrosis                        |       3           3  3                          3                        |             
      Mesothelium, Inflammation, Chronic   |                                                                          |             
          Active                           |                                                                         3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                              2                           |             
      Infiltration Cellular, Lymphocyte    |                                                    3                     |             
      Inflammation, Chronic Active         |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|             
                             DAY ON TEST   | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|             
                                           | 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    2           3  2  2     2  1  2     2  2           2  2           2   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                            2                                             |             
      Epithelium, Hyperplasia              |                         2  4                                             |             
      Serosa, Inflammation, Chronic Active |                                                                         2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Serosa, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                      1                       1                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                                                                        |             
      Capsule, Hyperplasia                 | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  3  2     1  1  1  2  2     2|             
      X-Zone, Vacuolization Cytoplasmic    |                            3                                             |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Congestion            |                3                          3                              |             
      Pars Distalis, Cyst                  |       X                                                                  |             
      Pars Distalis, Hyperplasia           | 3                       2                    2                       2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |             1                                                            |             
      Ultimobranchial Cyst                 |          X                                            X                  |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                2         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|             
                             DAY ON TEST   | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|             
                                           | 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 | X                 X     X     X                    X              X  X   |             
      Inflammation, Chronic                |                                              3                           |             
      Metaplasia, Osseous                  |                                                 3                        |             
      Pigmentation, Hemosiderin,           |                                                                          |             
          Cholesterol                      |                                                                          |             
      Polyarteritis                        |                                                             3            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                         3|             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2     2     2  3  2  3  2     1           2        2     2     2  3  3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                 3                       4|             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                       +                  |             
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
      Hyperplasia, Plasma Cell             |                                                                         3|             
      Inflammation                         |                                                                         3|             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  M  +|             
      Hyperplasia, Lymphoid                |             2                                   3                        |             
      Inflammation                         |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            2                                             |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  M  M  M  +  M  M  M  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                              3                    3      |             
      Hyperplasia, Plasma Cell             |                                                                         3|             
      Inflammation                         |                                                                         3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3     3     3  2  1  1              1        2           2           4|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Hyperplasia, Lymphoid                |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 5| 6| 6| 6| 6| 4|             
                             DAY ON TEST   | 6| 2| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 6| 1| 6| 6| 4| 6| 6| 6| 6| 8|             
                                           | 7| 6| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 1| 7| 7| 7| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 1| 2| 4| 5| 6| 7| 9|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Mineralization                       | 1           2     2  2  2  1        2     1     1     1     1  2     1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                4                                                         |             
      Hemorrhage                           |       2     1                                                            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 2                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                                                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                2                                                         |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    2                                   2                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           2        2                     |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6|     |            |
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|     |      L     |
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +      |  42        |
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infarct                              |                                                                          |      1  3.0|
      Mesothelium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                         1                                                |      2  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mesothelium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Mesothelium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Mesothelium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                         1                                                |      1  1.0|
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Perforation                          |                         X                                                |      1     |
      Mesothelium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Mesothelium, Inflammation, Chronic   |                                                                          |            |
          Active                           |                         1                                                |      2  1.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |    X                                                                     |      5     |
      Hematopoietic Cell Proliferation     |                         1                       1                        |      3  1.3|
      Infarct                              |                                                                          |      2  3.5|
      Infiltration Cellular, Mixed Cell    |                   1           1  2        1                              |      8  1.4|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                           X                 X            |      3     |
      Necrosis, Coagulative, Multifocal    |                1        3                                                |      4  1.5|
      Serosa, Fibrosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +     +           +           +            |   9        |
      Angiectasis                          |                                     3                                    |      1  3.0|
      Fat, Necrosis                        |                               3     3                       3            |      7  3.0|
      Mesothelium, Inflammation, Chronic   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6|     |            |
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|     |      L     |
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Fibrosis                             |                                                                          |      1  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 1                       2                                                |      3  2.0|
      Acinus, Atrophy                      |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |    2        2     2              2     2  2           2                  |     19  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ulcer                                |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |    2                                   2                                 |      4  2.5|
      Serosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Serosa, Inflammation, Chronic Active |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                              +                           |   2        |
      Dysplasia                            |                                              3                           |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Capsule, Hyperplasia                 | 3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     2  2  2  2  2  2      |     45  2.0|
      X-Zone, Vacuolization Cytoplasmic    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  +  M  M  M  +  M  M  M  M  +  M  M  +  +  +  +  M  M  +  +      |  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Pars Distalis, Congestion            |                                                                          |      2  3.0|
      Pars Distalis, Cyst                  |                      X                                         X         |      3     |
      Pars Distalis, Hyperplasia           |                   1           2                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Focal                  |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |                                                                          |      2     |
      Follicle, Cyst                       | X           X                                                            |      2     |
      Follicular Cell, Hyperplasia         | 2                                                                        |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6|     |            |
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|     |      L     |
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +      |  42        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Atrophy                              |                                                       2                  |      2  2.0|
      Cyst                                 |       X              X                       X     X  X  X               |     13     |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin,           |                                                                          |            |
          Cholesterol                      |                      3                                                   |      1  3.0|
      Polyarteritis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Dilatation                           |                2                       3           3                     |      3  2.7|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                   2                                                      |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 2  2              2  3     2                 2           2  3  2         |     23  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia, Neutrophil              |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                         +           +           +                 +      |   5        |
      Pancreatic, Hyperplasia, Histiocytic |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +  +      |  40        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  M  +  +      |  39        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  I  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +      |  43        |
      Hemorrhage                           |                                                             3            |      2  2.5|
      Hyperplasia, Histiocytic             |                                     3                                    |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  +  M  +  M  M  +  M  M  +  +  I  M  M  +  M  +  M  +  +  +      |  28        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6|     |            |
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|     |      L     |
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hematopoietic Cell Proliferation     |                1        2     3     3  1  2     3  1                     |     18  2.1|
      Hyperplasia, Lymphoid                |             2                                                            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +      |  46        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Compression                          |                                                          X               |      1     |
      Mineralization                       |                      1     2     2  1     2              2  1            |     20  1.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Congestion                           |                                  3                                       |      2  3.5|
      Hemorrhage                           |                                                                          |      2  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                          +                                    |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |          2                                                               |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 5| 6| 6| 6| 4| 6| 6| 6| 5| 6| 6|     |            |
                             DAY ON TEST   | 6| 6| 0| 6| 6| 6| 6| 6| 2| 6| 6| 3| 9| 6| 6| 6| 0| 6| 6| 6| 9| 6| 6|     |            |
                                           | 7| 7| 3| 7| 7| 7| 7| 7| 1| 7| 7| 1| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    CONTROL                                | 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1|     |      L     |
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|             
                             DAY ON TEST   | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|             
                                           | 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    312 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  +  +  +  A  A  +  +  +  +  M  A  +  +  +  +  +  A  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  A|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                2                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  I  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  +  A  A  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  A|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia, Lymphoid |                2                                                         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    1  2     2                       1        3     2                     |             
      Eosinophilic Focus                   | X  X  X  X              X  X  X     X        X           X               |             
      Fatty Change                         |                3     4                                                   |             
      Hematopoietic Cell Proliferation     |                                  2     2  1  1     1  2     3        1   |             
      Infiltration Cellular, Mixed Cell    | 4                 1           3                                          |             
      Necrosis, Coagulative, Multifocal    | 4  2     4  4  2     3                                                   |             
      Centrilobular, Necrosis              |                                              2                           |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +  +  +  +              +                                 |             
      Cyst                                 |          X                                                               |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Necrosis                        |                   3  3                 3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    2        1                             2                              |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Capsule, Hyperplasia                 | 2  2  2  2  2     2  2  2  2  2  2     2  3  2  2  1  2  2  2  2  2  2   |             
      Capsule, Mineralization              |                                     2                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|             
                             DAY ON TEST   | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|             
                                           | 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    312 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  M  +  +  M  M  M  M  +  +  +  M  +  M  +  +  M  +  M  M  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |          2           2                                                   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Focal                  |                                                                1         |             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Congestion                           |                                                                         2|             
      Cyst                                 | X  X     X  X     X  X        X     X  X                 X  X  X  X  X   |             
      Pigmentation, Lipofuscin             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |       2                                                                  |             
      Inflammation, Suppurative            |    2                                                                     |             
      Endometrium, Hyperplasia, Cystic     | 2        2  2     3     2  2  2  2  2  2  2  2           2  2        2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Erythrocyte             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             
      Iliac, Angiectasis                   |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Inflammation, Chronic Active  |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  I  +  +  M  +  M  +  +  M  M  +  +  +  +  +  +  +  +  M  +  M  +  M|             
      Hemorrhage                           |                                                          2               |             
      Hyperplasia, Histiocytic             |                                                       2                  |             
      Hyperplasia, Lymphoid                |                   2                          2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  I  +  M  +  M  +  +  +  +  M  +  +  M  +  M  +  +  M  M  M  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|             
                             DAY ON TEST   | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|             
                                           | 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    312 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  I  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Hemorrhage                           |                3                                                         |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                2  2                          2                           |             
      Inflammation, Chronic Active         |                            2                          3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  +  M  M  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                 2     2                  |             
      Hyperplasia, Lymphoid                |                   2                                                      |             
      Pigmentation, Hemosiderin            |                      3                                                   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  3  3  3  3  2              2  2  2  2  4  3  3  3  3  3  3     2  3   |             
      Pigmentation, Melanin                |                      2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |                                                                X         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       | 2              1                    2                             2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   2      |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1                                                                        |             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Mixed Cell                      |          2                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Respiratory Epithelium, Cytoplasmic  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 5| 5| 6| 6| 4| 6| 6| 6| 6| 6| 5| 6| 6| 4| 6| 5| 4| 6| 6| 6| 6| 5| 6| 4|             
                             DAY ON TEST   | 1| 3| 4| 3| 0| 5| 6| 0| 3| 5| 4| 3| 0| 6| 2| 5| 4| 9| 1| 1| 3| 6| 6| 3| 5|             
                                           | 4| 0| 1| 6| 0| 4| 7| 0| 9| 7| 3| 9| 3| 7| 9| 9| 1| 3| 4| 5| 1| 7| 6| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    312 PPM                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
                                           | 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 9| 2| 3| 4| 6| 7| 8| 0| 1| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
          Alteration                       |                   3                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +     +                                         +     +   |             
      Hyperplasia                          |                3     3                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct, Chronic                     |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Nephropathy                          |       1                                                                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6|     |            |
                             DAY ON TEST   | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3|     |            |
                                           | 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    312 PPM                                | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  M  A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  A  +      |  36        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +      |  42        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +      |  37        |
      Hemorrhage                           |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +      |  39        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |    1                                   4                       2         |      9  2.0|
      Eosinophilic Focus                   |                            X        X     X                              |     13     |
      Fatty Change                         |    2                                                                     |      3  3.0|
      Hematopoietic Cell Proliferation     |       2  1  2     2           1        2  1  1        2  2        1      |     19  1.6|
      Infiltration Cellular, Mixed Cell    | 3              3                 3  3  2                                 |      8  2.8|
      Necrosis, Coagulative, Multifocal    |                3                 3  3                       2  4         |     11  3.1|
      Centrilobular, Necrosis              | 3  2                                                                     |      3  2.3|
      Serosa, Fibrosis                     |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +  +        +  +  +                 +        +         |  13        |
      Cyst                                 |                                                                          |      1     |
      Fat, Hemorrhage                      |                                                       2                  |      1  2.0|
      Fat, Necrosis                        |                   3  3        3     3                          3         |      8  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +      |  47        |
      Acinus, Atrophy                      |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                               2                    1        2            |      6  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia, Squamous                |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6|     |            |
                             DAY ON TEST   | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3|     |            |
                                           | 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    312 PPM                                | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|     |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cyst                                 |                   X                                                      |      1     |
      Capsule, Hyperplasia                 | 2  2  2  2  2  3  2  3  2  2  2  2  3  2  2  2  2  3  2  2  2  2  2      |     45  2.1|
      Capsule, Mineralization              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +      |  45        |
      Hyperplasia                          |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  +  M  +  +  +  M  M  M  M  +  +  +  +  M  M  +  +  +  +      |  25        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +      |  45        |
      Pars Distalis, Hyperplasia           |                                     1                                    |      3  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Focal                  |                                                                          |      1  1.0|
      Ultimobranchial Cyst                 |          X                                   X                           |      2     |
      Follicle, Cyst                       |                      X              X                                    |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  M  +      |  42        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Atrophy                              |                                     2        3  2     3                  |      4  2.5|
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 | X     X  X     X  X                 X  X  X  X     X     X     X  X      |     27     |
      Pigmentation, Lipofuscin             |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Dilatation                           |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |             2                    2              2           2  2  2      |     21  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia, Erythrocyte             |                               3                          2               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +              +                             +     +     +      |   6        |
      Iliac, Angiectasis                   |                                                                   3      |      1  3.0|
      Iliac, Hyperplasia, Lymphoid         |                                                                   3      |      1  3.0|
      Iliac, Inflammation, Chronic Active  |                                                                   2      |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6|     |            |
                             DAY ON TEST   | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3|     |            |
                                           | 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    312 PPM                                | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Hyperplasia, Lymphoid    |                                                             3            |      1  3.0|
      Renal, Hemorrhage                    |       2                                                                  |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +      |  36        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                  2                          2     2      |      5  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  I  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +      |  35        |
      Hemorrhage                           |                                                 2                        |      1  2.0|
      Hyperplasia, Lymphoid                |                                                             2            |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +      |  40        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                                                 2                        |      1  2.0|
      Hyperplasia, Lymphoid                |                                                             2     2      |      5  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | I  +  +  +  +  I  +  I  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +      |  35        |
      Hyperplasia, Histiocytic             |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |                                                             2            |      2  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hematopoietic Cell Proliferation     | 3  3  3  3  3  3  4  2     2  3  3  2  3  3  3  2  3     3  3     3      |     39  2.8|
      Pigmentation, Melanin                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +      |  42        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +      |  46        |
      Hyperplasia                          |                                                             3            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Congestion                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Fracture Healed                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Compression                          | X                                                                        |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 6| 6| 4| 5| 6| 6| 5| 6| 6| 5| 6| 6| 5| 6| 6| 6| 6| 6| 6| 5| 6|     |            |
                             DAY ON TEST   | 0| 8| 4| 1| 2| 9| 4| 4| 3| 6| 4| 4| 0| 5| 4| 3| 1| 4| 4| 1| 1| 8| 3|     |            |
                                           | 7| 8| 6| 4| 9| 6| 4| 9| 0| 7| 6| 1| 9| 1| 1| 8| 4| 6| 5| 4| 8| 5| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    312 PPM                                | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|     |      L     |
                                           | 6| 7| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2|     |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                       3                  |      1  3.0|
      Mineralization                       |                2  2                             2  1        2            |      9  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |             2           2                             3  2               |      5  2.2|
      Pigmentation, Hemosiderin            |             2                                         2                  |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                               2                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Interstitium, Infiltration Cellular, |                                                                          |            |
           Mixed Cell                      |          2                                                  3            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Respiratory Epithelium, Cytoplasmic  |                                                                          |            |
          Alteration                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +                                 |   6        |
      Hyperplasia                          |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infarct, Chronic                     |                                           1  2                           |      2  1.5|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                             3            |      1  3.0|
      Nephropathy                          |                                                                          |      1  1.0|
      Pigmentation, Hemosiderin            |    4                                                                     |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
      Hyperplasia, Lymphoid                |                                                             2            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|             
                                           | 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  A  +  +  A  +  +  +  +  +  M  +  M  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +     +  +  +  +  +  A  A  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  A  +  +  +     +  +  +  +  +  A  A  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 4           2              1  4                                          |             
      Basophilic Focus                     |                                     X                                    |             
      Eosinophilic Focus                   |                X           X  X           X     X           X            |             
      Hematopoietic Cell Proliferation     | 4        3  1     1  2              2                       1            |             
      Hyperplasia, Lymphoid                |                                                             3            |             
      Infiltration Cellular, Mixed Cell    | 3           1                                                            |             
      Necrosis, Coagulative, Multifocal    | 4                                4                    3                  |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                  +         |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mineralization                       |                                                                          |             
      Fat, Necrosis                        |             3                                                  3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
      Fibrosis                             |    3                                                                     |             
      Inflammation, Acute                  |    3                                                                     |             
      Acinus, Atrophy                      |    3                    3                             4                  |             
      Duct, Ectasia                        |                         4                                                |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                               3           2                              |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Polyarteritis                        |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
      Capsule, Hyperplasia                 | 2  2  2  2  2  2  2  2  2  2  2  2  3  2  2     2  3  2  3  3  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|             
                                           | 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      X-Zone, Vacuolization Cytoplasmic    |       3                                                                  |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  M  M  M  +  M  M  M  M  +  +     +  +  +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  M  +  +  +|             
      Pars Distalis, Hyperplasia           |             1                 4                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +|             
      Polyarteritis                        |                            3                                             |             
      Ultimobranchial Cyst                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  M  +  +  +  +  +  M  M  +  +  +  M  +     M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    2        2                                               2            |             
      Congestion                           |                                                                   3      |             
      Cyst                                 | X        X  X                 X  X  X           X     X     X            |             
      Hemorrhage                           |                   2                                                      |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
      Dilatation                           |                3                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2     3  2        2     2  3  2  3           3     3  2           1  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Erythrocyte             |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                    +                                                   |             
      Axillary, Hyperplasia, Lymphoid      |                                                                          |             
      Iliac, Hyperplasia, Lymphoid         | 4                                                                        |             
      Lumbar, Hyperplasia, Lymphoid        | 3                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  M|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                  2                                       |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |             2                                         3                  |             
      Hyperplasia, Plasma Cell             |                                           2                              |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  +  I  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|             
                                           | 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                    3                     |             
      Hyperplasia, Histiocytic             |                                           2                              |             
      Hyperplasia, Lymphoid                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  M  A  +  +|             
      Hemorrhage                           |                                  3                                   3   |             
      Hyperplasia, Histiocytic             | 3                                                                       2|             
      Hyperplasia, Lymphoid                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  +  M  +  +  M  +  +  +  +  M  +     +  +  +  M  +  +  +  +  M|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |    3                                                  3                  |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  A  +  +|             
      Hematopoietic Cell Proliferation     | 3  3  3  3  3  3  3  3  3     2  3  4  4  3     3  3  1  3  3  4     3  2|             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Capsule, Hematocyst                  |             X                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  I  +  +  +  +  +  +     +  +  +  +  +  M  +  M  +|             
      Atrophy                              |                                                                          |             
      Necrosis                             |             2                                         3                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  M  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 2                 2           1  1                             2        2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  A  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                      3   |             
      Inflammation, Chronic                |                                                       3                  |             
      Pigmentation, Hemoglobin             |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Mixed Cell                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 6| 5| 6| 4| 5| 4| 6| 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 5| 4| 5|             
                             DAY ON TEST   | 8| 6| 1| 5| 1| 6| 3| 8| 4| 9| 6| 7| 3| 6| 4| 8| 6| 9| 3| 0| 2| 3| 1| 5| 9|             
                                           | 0| 9| 9| 5| 5| 9| 1| 1| 1| 2| 7| 8| 0| 6| 1| 0| 7| 5| 0| 8| 9| 5| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    625 PPM                                | 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 5| 6| 8| 9| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 8| 9|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +     +                                                            |             
      Hyperplasia                          |       2     2                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
      Infarct, Chronic                     |                   2                                                      |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                     1           2                        |             
      Inflammation, Chronic Active         | 3                                                                        |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |                                                                          |             
      Polyarteritis                        |                            2                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  A  A  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         | 2                                                                        |             
      Metaplasia, Squamous                 | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5|     |            |
                             DAY ON TEST   | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5|     |            |
                                           | 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |      L     |
                                           | 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  M  +  A  +  +  +  +  A  +  +  +  +  +  A  +  A  +  +  +  +  A      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A      |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A      |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A      |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  A  +  +  +  +  A      |  39        |
      Peyer's Patch, Hyperplasia, Lymphoid |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A      |  39        |
      Peyer's Patch, Hyperplasia, Lymphoid | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A      |  40        |
      Peyer's Patch, Hyperplasia, Lymphoid | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Angiectasis                          |                                                                1  2      |      6  2.3|
      Basophilic Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                      X                 X        X           X  X  X      |     12     |
      Hematopoietic Cell Proliferation     |    1     2     1                 2  3     3                              |     13  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Mixed Cell    |       3        3  2                             3  4        2  4         |      9  2.8|
      Necrosis, Coagulative, Multifocal    |                   1  1                          4  4     1               |      8  2.8|
      Centrilobular, Necrosis              |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +     +           +                    +           +               |   7        |
      Hyperplasia, Lymphoid                |             3                                                            |      1  3.0|
      Mineralization                       |                         2                                                |      1  2.0|
      Fat, Necrosis                        |       3                 3                    3           3               |      6  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +      |  44        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Acinus, Atrophy                      |                                                                          |      3  3.3|
      Duct, Ectasia                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 2  1                    2        2     2        2        2               |      9  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Polyarteritis                        |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5|     |            |
                             DAY ON TEST   | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5|     |            |
                                           | 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |      L     |
                                           | 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cyst                                 |                                                                          |      1     |
      Capsule, Hyperplasia                 | 2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  3  2  2  3  2  3  2      |     47  2.1|
      X-Zone, Vacuolization Cytoplasmic    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Angiectasis                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  M  +  +  M  +  M  M      |  27        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
      Pars Distalis, Hyperplasia           |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Polyarteritis                        |                                                                          |      1  3.0|
      Ultimobranchial Cyst                 |                X                                            X            |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +      |  38        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Atrophy                              |                         2                                      3         |      5  2.2|
      Congestion                           |                                              3                           |      2  3.0|
      Cyst                                 |          X              X        X     X        X           X  X         |     16     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |       3                                                                  |      1  3.0|
      Necrosis                             |       3                                                                  |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 2              2        2     4        3           3  3  2  2  4         |     24  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Hyperplasia, Erythrocyte             |          3                                                               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +                                   +                              |   4        |
      Axillary, Hyperplasia, Lymphoid      |       2                                                                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5|     |            |
                             DAY ON TEST   | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5|     |            |
                                           | 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |      L     |
                                           | 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  A  +  +  +  +  M      |  40        |
      Congestion                           |    2                                                                     |      1  2.0|
      Hemorrhage                           |                               2                                          |      2  2.0|
      Hyperplasia, Histiocytic             |                                                          2               |      1  2.0|
      Hyperplasia, Lymphoid                |                                        3                                 |      3  2.7|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  M  +  +  +  +  +  +  +  +  I  M  +  M  +  M  +  M  +  +  +      |  34        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |             3                                                            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  A  +  +  +  +  +  +  +      |  41        |
      Hemorrhage                           |                            2                                             |      3  2.7|
      Hyperplasia, Histiocytic             |                                                       2                  |      3  2.3|
      Hyperplasia, Lymphoid                |                2                    3              4                     |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  M  +      |  35        |
      Congestion                           |    2                                                                     |      1  2.0|
      Hemorrhage                           |                               2                 3  3                     |      3  2.7|
      Hyperplasia, Lymphoid                |          2                                               2               |      4  2.5|
      Pigmentation, Hemosiderin            |                               2                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Hematopoietic Cell Proliferation     | 2  3  2  3  3  3  2     3     2  4  3  3  4     3  3     3  2  2  3      |     41  2.9|
      Hyperplasia, Lymphoid                |                                        3                                 |      2  3.0|
      Capsule, Hematocyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  I  +  +  +  +  +  +  +      |  39        |
      Atrophy                              |                                                    3                     |      1  3.0|
      Necrosis                             |                               3                          3               |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Hyperplasia                          |                      2              2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 5| 5| 5| 6| 6| 6| 6| 6| 6| 4| 6| 6| 4| 5| 6| 6| 5| 5| 6| 6| 5|     |            |
                             DAY ON TEST   | 6| 8| 6| 8| 4| 1| 6| 5| 6| 5| 3| 7| 5| 5| 8| 5| 6| 4| 4| 6| 6| 5| 5|     |            |
                                           | 7| 9| 9| 9| 1| 4| 7| 2| 7| 0| 6| 6| 3| 3| 4| 2| 1| 2| 1| 9| 7| 3| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     |      A     |
    625 PPM                                | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |      L     |
                                           | 1| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Mineralization                       |    1           2        2  2  2           1  1     1                     |     14  1.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +      |  43        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Congestion                           |                            3                                             |      1  3.0|
      Hemorrhage                           |    3  2              2        2                                          |      5  2.4|
      Inflammation, Chronic                |                                                    1                     |      2  2.0|
      Pigmentation, Hemoglobin             |                                        3                                 |      1  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       1                                4                                 |      2  2.5|
      Interstitium, Infiltration Cellular, |                                                                          |            |
           Mixed Cell                      |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +      |  45        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                              +           +               |   4        |
      Hyperplasia                          |                                                          1               |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Infarct, Chronic                     |                                                                          |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                     2           2                        |      4  1.8|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                 2                        |      1  2.0|
      Nephropathy                          |                                                             1            |      1  1.0|
      Polyarteritis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
      Hyperplasia, Lymphoid                |                                                 3  3                     |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|             
                             DAY ON TEST   | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|             
                                           | 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  A  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  I  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  M  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  A  A  +  A  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        2                                 |             
      Basophilic Focus                     |                   X                                                     X|             
      Eosinophilic Focus                   |    X                    X                                            X  X|             
      Hematopoietic Cell Proliferation     |       2        1  3           2           2              2  2  1     1   |             
      Infarct                              |                                  4                                       |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative, Multifocal    |                2                                                        2|             
      Thrombosis                           |                         4                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +     +              +                             +         |             
      Fat, Necrosis                        |             4     3              3                             3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Focal, Suppurative     |    2                                                                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              | 1                                         3  2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                         +|             
      Dysplasia                            |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                      2                                                   |             
      Hyperplasia                          |                                           2                              |             
      Capsule, Hyperplasia                 |    2  1  2  2  2  1  2  2  2  3  2     2  2  2  2     2  2  2     2  2  2|             
      X-Zone, Vacuolization Cytoplasmic    |                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|             
                             DAY ON TEST   | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|             
                                           | 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  M  +  A  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                  3                                       |             
      Pars Distalis, Congestion            |                                                                          |             
      Pars Distalis, Cyst                  |             X                                                            |             
      Pars Distalis, Hyperplasia           |                            2              2                          2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  I  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |          X                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2                    2      |             
      Congestion                           |                                                                          |             
      Cyst                                 |    X     X           X  X        X        X                 X  X  X  X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |             4                                                            |             
      Hemorrhage                           |                                                 2                        |             
      Endometrium, Hyperplasia, Cystic     |    3  3  3     2  1  3           2     3        4  2  3  2  4           3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                              +                           |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                 +           +            |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  M  +  +  +  +  +  M|             
      Hemorrhage                           |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  M  A  M  M  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |    2                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                3         |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  M  +  M  M  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  M  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 1| 5| 6| 6| 5| 4| 5| 5| 6| 5| 5| 6| 6|             
                             DAY ON TEST   | 4| 4| 6| 5| 8| 1| 0| 4| 8| 8| 5| 0| 3| 3| 2| 4| 5| 6| 6| 8| 4| 8| 8| 6| 6|             
                                           | 4| 1| 5| 5| 6| 8| 7| 8| 6| 8| 2| 8| 5| 6| 9| 2| 2| 8| 3| 6| 6| 0| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1250 PPM                               | 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 7| 8| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3  3  3  3  3  2  3  3  3  3  3     3  3  3  3     3  3  3  1  3  3   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Mineralization                       |    2     2  1  1           1     1     1              2  1  1  1         |             
      Ventricle, Dilatation                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           4  3                           |             
      Pigmentation, Hemosiderin            |                                           4  3                           |             
      Alveolar Epithelium, Hyperplasia     |                               4                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                      2                    4                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                         2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     | 1                                                                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                       +           +   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Glomerulus, Amyloid Deposition       | 4                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  I  +  A  +  I  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6|     |            |
                             DAY ON TEST   | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1|     |            |
                                           | 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    1250 PPM                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|     |      L     |
                                           | 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  A  M  M  +  A  A  +  +      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  A  A  +  +      |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +      |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  A  +  A  +  A  A  +  +      |  36        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  +  +  +  +  +  +  A  A  +  +  +  +  A  A  +  +  A  A  +  +      |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  A  A  +  +  A  A  +  +      |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  A  A  +  +  A  A  +  +      |  35        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Angiectasis                          |                      3  2                             3                  |      4  2.5|
      Basophilic Focus                     |                                                                          |      2     |
      Eosinophilic Focus                   | X        X           X                                                   |      7     |
      Hematopoietic Cell Proliferation     |                3           2        2           2  2           2         |     15  1.9|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Mixed Cell    |          2                    3                          3               |      3  2.7|
      Mixed Cell Focus                     |                                                       X                  |      1     |
      Necrosis, Coagulative, Multifocal    |             3                 4  3           4           4  4            |      8  3.3|
      Thrombosis                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +     +                                                               |   6        |
      Fat, Necrosis                        |    3                                                                     |      5  3.2|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Acinus, Vacuolization Cytoplasmic    |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 2                    2                                                   |      2  2.0|
      Inflammation, Focal, Suppurative     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Epithelium, Hyperplasia              |                                     1                                    |      4  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                      +                    +                              |   3        |
      Dysplasia                            |                      3                    3                              |      2  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6|     |            |
                             DAY ON TEST   | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1|     |            |
                                           | 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    1250 PPM                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|     |      L     |
                                           | 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4|     |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Degeneration, Fatty                  |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Capsule, Hyperplasia                 | 2  2  2  3  1  2  2  1  2  2  2  2  2     1  2  2  2  3  2        2      |     41  2.0|
      X-Zone, Vacuolization Cytoplasmic    |                                                       3                  |      2  2.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  M  M  +  +  +  M  +  M  +  +  M  M  M  M  M  +  +  M      |  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +      |  46        |
      Pars Distalis, Angiectasis           |                                                 2                        |      2  2.5|
      Pars Distalis, Congestion            |       3                          3                                       |      2  3.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                3        3                                                |      5  2.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Ultimobranchial Cyst                 |                                                                X         |      2     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | M  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +      |  46        |
      Atrophy                              |                                                                          |      2  2.0|
      Congestion                           |                                  2                                       |      1  2.0|
      Cyst                                 |       X  X  X     X           X           X  X     X                     |     18     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Dilatation                           |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |       3  3              3           2  3           2  2     3  1  2      |     24  2.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia, Neutrophil              |                                        3                                 |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                          +     +        +               |   6        |
      Pancreatic, Hyperplasia, Lymphoid    |                3                                                         |      1  3.0|
      Renal, Hemorrhage                    |                                           3              3               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  M  +  +  +  +  +      |  38        |
      Hemorrhage                           |                                  2     3                 3               |      3  2.7|
      Pigmentation, Hemosiderin            |                                                          2               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6|     |            |
                             DAY ON TEST   | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1|     |            |
                                           | 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    1250 PPM                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|     |      L     |
                                           | 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  M  +  M  +  +  +  +  M  M  M  +  +  +  +  M  +  +  +  M  M  M      |  32        |
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                     2                                    |      1  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  A  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +      |  43        |
      Angiectasis                          |          3                                                               |      1  3.0|
      Hemorrhage                           |                                                             2            |      2  2.5|
      Hyperplasia, Lymphoid                |                                        2                                 |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  M  +  +  M  +  +      |  33        |
      Congestion                           |                               4                          3               |      2  3.5|
      Hematopoietic Cell Proliferation     |                                                                2         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hematopoietic Cell Proliferation     |    3  2  2  3  2  3     3  3  3  3  3  3  4  3  3  3     3  3  3  4      |     41  2.9|
      Hyperplasia, Lymphoid                |                                        1                                 |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  M      |  38        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +      |  46        |
      Hyperplasia                          |                            3                          3                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Compression                          |                                                       X                  |      1     |
      Mineralization                       | 2  2           2     2     2  2  1  2                 2  2               |     21  1.6|
      Ventricle, Dilatation                |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemorrhage                           |             4                                                            |      3  3.7|
      Pigmentation, Hemosiderin            |             3                                                            |      3  3.3|
      Alveolar Epithelium, Hyperplasia     |                                                          2               |      2  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |             3                                                            |      3  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +      |  45        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 6| 5| 6| 6| 5| 6| 6| 6| 5| 5| 3| 4| 5| 5| 6| 5| 6| 5| 4| 6|     |            |
                             DAY ON TEST   | 0| 3| 8| 6| 6| 4| 0| 4| 6| 2| 0| 1| 9| 6| 8| 9| 8| 0| 8| 2| 0| 8| 1|     |            |
                                           | 8| 9| 5| 7| 9| 6| 8| 1| 7| 6| 6| 3| 7| 6| 4| 7| 7| 0| 8| 3| 9| 4| 9|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    1250 PPM                               | 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6|     |      L     |
                                           | 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 3| 4|     |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                    +                                      +         |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Metaplasia, Osseous                  |                                                       2                  |      1  2.0|
      Pigmentation, Hemosiderin            |                               3                                          |      1  3.0|
      Glomerulus, Amyloid Deposition       |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  +  M  +  M  I      |  37        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  M  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peyer's Patch, Inflammation, Chronic |                                                                          |             
          Active                           | 2                                                                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                  X                                       |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     1                                    |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                             3            |             
      Mixed Cell Focus                     |                               X                                          |             
      Necrosis, Coagulative, Multifocal    |                                  2        1                 3            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                                          |             
      Fat, Necrosis                        |                               3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |    1                 1                                            1      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Granuloma                            |                                                                          |             
      Hemorrhage                           |                                                       3                  |             
      Inflammation, Focal                  |                         2                                                |             
      Epithelium, Hyperplasia              |                                                                          |             
      Serosa, Inflammation                 |                                                       2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                               +                    +                     |             
      Dysplasia                            |                                                    3                     |             
      Inflammation, Suppurative            |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1  1                                                      |             
      Atrium, Thrombosis                   |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Capsule, Hyperplasia                 | 1  2  1  1  1        1        1     1  1  1  1  1  2  1           1     1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  M  +  M  +  M  M  +  +  +  M  +  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                           X                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          A                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                        1              1                  |             
      Inflammation, Chronic                |                                              2  4                       3|             
      Inflammation, Suppurative            |                                     3                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                           3  3     3                     |             
      Hyperplasia                          |       3                                                                  |             
      Inflammation, Chronic                |       2                                                                  |             
      Inflammation, Suppurative            |                                     2                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                     1                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                                                 +     +                  |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  I  +  +  +  +  +  M  M  M  +  +  +  +|             
      Hemorrhage                           |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic             |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  I  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M  M  +|             
      Hyperplasia, Lymphoid                |                                                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                     3     2              2           2  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
      Prepuce, Acanthosis                  |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                2         |             
      Mineralization                       | 2  1        1  2                 2        2        1  2        2  2      |             
      Necrosis, Liquifactive               |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 2           1                                         3  1        2      |             
      Alveolar Epithelium, Hyperplasia     |                                              1                           |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               2           3              1     2         |             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Mixed Cell                      |                                                          2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Respiratory Epithelium, Cytoplasmic  |                                                                          |             
          Alteration                       |                                                 3                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration               |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6|             
                             DAY ON TEST   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 5| 3| 6| 6| 6| 6| 6| 5| 6| 6| 9| 6| 6| 6|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 0| 9| 6| 6| 6| 6| 6| 0| 6| 6| 7| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3|             
                                           | 2| 4| 5| 6| 7| 9| 0| 2| 4| 5| 6| 7| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       M     +                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +  +                                               +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X                           |             
      Hemorrhage                           |                                                                3         |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |          4                                                               |             
      Inflammation, Chronic Active         |                                     4                                    |             
      Inflammation, Suppurative            |                                  3                                       |             
      Nephropathy                          | 1  1  1  1  1  1     1  1              1  1        1     1  1     1  3  1|             
      Renal Tubule, Karyomegaly            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                            1                                             |             
      Inflammation, Chronic Active         |                                  3                                       |             
      Inflammation, Suppurative            |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                             DAY ON TEST   | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                                           | 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|     |      L     |
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Peyer's Patch, Inflammation, Chronic |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Basophilic Focus                     |                         X                                                |      1     |
      Clear Cell Focus                     |                                  X                                       |      1     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change                         |                   2                                      2               |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Infarct                              |             4                                                            |      1  4.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Mixed Cell Focus                     |                                                                   X      |      2     |
      Necrosis, Coagulative, Multifocal    |                                        1                                 |      4  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   2        |
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Granuloma                            |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                2                 2        2                 2            |      7  1.6|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Foreign Body                         |                2                                                         |      1  2.0|
      Granuloma                            |                2                                                         |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                2                       2                                 |      2  2.0|
      Serosa, Inflammation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Dysplasia                            |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                             DAY ON TEST   | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                                           | 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|     |      L     |
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       |                                                                          |      2  1.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Accessory Adrenal Cortical Nodule    |                4                                                         |      1  4.0|
      Hyperplasia                          |                      2                                                   |      1  2.0|
      Capsule, Hyperplasia                 | 1  1           1  2  1        1  1  2  1  1        2  1           1      |     29  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |                               2                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  M  +  +  +  M  M  M  M  +  +  +  +  M  +  +      |  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +      |  47        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Follicle, Cyst                       |                                                                X         |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ectasia                              |                                                 2                 3      |      2  2.5|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |    1     1  1                                   2                        |      6  1.2|
      Inflammation, Chronic                |                   3                          4                           |      5  3.2|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Inflammation, Suppurative            |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Dilatation                           |                                              3                           |      4  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                              2                           |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                             DAY ON TEST   | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                                           | 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|     |      L     |
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia, Neutrophil              |                                              3                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                              +                           |   3        |
      Iliac, Hyperplasia, Lymphoid         |                                              3                           |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  M  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +      |  36        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  +  M  +  M  +  +  +      |  36        |
      Hemorrhage                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hemorrhage                           |                3                                                         |      1  3.0|
      Hyperplasia, Histiocytic             |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  M  +  M  +  +  +  +  M  M  M  M  +  +  +  M  +  +  +  +  M      |  30        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hematopoietic Cell Proliferation     |             3  3  1  1  2  1           2     3              3            |     14  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +      |  43        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M      |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Acanthosis                           |                                              2                           |      1  2.0|
      Inflammation, Chronic                |                                        3     4                           |      2  3.5|
      Ulcer                                |                                        3     4                           |      2  3.5|
      Prepuce, Acanthosis                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization                       |    2  1  2     2  2     1     2  2  2           2  2        1  1         |     23  1.7|
      Necrosis, Liquifactive               | 3                                                                        |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cytoplasmic Alteration               |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 5| 6| 6| 6| 4| 5| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                             DAY ON TEST   | 5| 6| 6| 6| 4| 6| 6| 6| 7| 3| 6| 6| 6| 9| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |            |
                                           | 2| 6| 6| 6| 1| 6| 6| 6| 5| 8| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5|     |      L     |
                                           | 2| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8|     |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |             2                                                            |      6  1.8|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      4  2.0|
      Interstitium, Infiltration Cellular, |                                                                          |            |
           Mixed Cell                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Suppurative            |                                           1                              |      1  1.0|
      Respiratory Epithelium, Cytoplasmic  |                                                                          |            |
          Alteration                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Cytoplasmic Alteration               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                        +  +                    +         |   6        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cyst                                 |                                                             X            |      2     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                        2                                 |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                              2                           |      2  2.5|
      Nephropathy                          |    1  1  1  1  3  1  1  2     1  1  1     1     1  1  1        1         |     32  1.2|
      Renal Tubule, Karyomegaly            |                               1                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                              4                           |      2  3.5|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|             
                                           | 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    312 PPM                                | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  A  A  A  +  +  +  A  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                             3        3        2   |             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                        X           X                    X|             
      Hematopoietic Cell Proliferation     |                1                                                         |             
      Hemorrhage                           |                                  4                                       |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                           3        1              2      |             
      Mixed Cell Focus                     |                            X                                             |             
      Necrosis, Coagulative, Multifocal    |                                                       4                  |             
      Thrombosis                           |                                                                      4   |             
      Bile Duct, Hyperplasia               |                                           3                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Fat, Necrosis                        |                                                                         3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                   2                    2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                      3   |             
      Epithelium, Hyperplasia              |       1                    2                                         2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                       +                           |             
      Dysplasia                            |                      1                                                   |             
      Peridontal Tissue, Proliferation     |                                                                          |             
          Connective Tissue                |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
      Hyperplasia                          |          2                                                               |             
      Capsule, Hyperplasia                 | 1  1     2        1  1  1  1  1        1        2  1  1  1  1  1  2  1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|             
                                           | 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    312 PPM                                | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  M  M  M  +  M  +  M  M  M  +  +  M  +  +  M  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
      Pars Intermedia, Hemorrhage          |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                      3                                                   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                      2                                   1           1   |             
      Inflammation, Chronic                |    3           2                                               1         |             
      Inflammation, Suppurative            | 3                             3                             3     4      |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       3                                                                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        4                                 |             
      Inflammation, Suppurative            |       4                                                                  |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  I  M  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  M  M  +|             
      Congestion                           |                                                       2                  |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |    3                       2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|             
                                           | 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    312 PPM                                | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                           2              3               |             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Inflammation, Chronic Active         |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  M  M  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  M|             
      Congestion                           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 4     2  2  3  3     2  3        4     3  1     3     2  3  3  3        1|             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Pigmentation, Melanin                |                                     1                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   3                             3  3                     |             
      Ulcer                                |                                                    4           4  3      |             
      Prepuce, Acanthosis                  |                                                 2                 2      |             
      Prepuce, Inflammation, Chronic       |                                                             4  4         |             
      Prepuce, Pigmentation, Melanin       |                                                 3                        |             
      Prepuce, Ulcer                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization                       | 2     1  2     2           1                          2        2     2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     3                                    |             
      Crystals                             |                                                                          |             
      Hemorrhage                           |                                                    2                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                      3                                      2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Proliferation Connective Tissue,     |                                                                          |             
           Multifocal                      |                                              3                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 6| 5| 6| 5| 5| 5| 6| 5| 6| 6| 6| 0| 5| 6| 0| 5| 6| 5| 6| 6| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 1| 0| 6| 5| 4| 4| 6| 4| 6| 4| 0| 7| 7| 6| 4| 6| 1| 2| 3| 2| 1| 6| 6| 6|             
                                           | 6| 4| 9| 6| 1| 1| 1| 6| 1| 6| 9| 0| 5| 3| 0| 4| 9| 6| 2| 1| 5| 4| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    312 PPM                                | 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 7| 8| 0| 1| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 5| 6| 7| 8| 0| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +                       +           +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Nephropathy                          | 1     1        1     1  1  1           1                                 |             
      Renal Tubule, Dilatation             |          1                                                     1  1      |             
      Renal Tubule, Karyomegaly            |                               1                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5|     |            |
                             DAY ON TEST   | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9|     |            |
                                           | 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    312 PPM                                | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|     |      L     |
                                           | 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  M  +  +  +  M  +  +  A  A  +  +  +  A  +  A  +  +  +  +  +      |  35        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  +  A  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +      |  38        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  40        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |                   2        2                                             |      6  2.3|
      Basophilic Focus                     |                X                                                         |      1     |
      Eosinophilic Focus                   | X        X                                   X                           |      6     |
      Hematopoietic Cell Proliferation     |             2                                                            |      2  1.5|
      Hemorrhage                           |                                                                          |      1  4.0|
      Infarct                              |    4                 4  4                    4                 4  3      |      6  3.8|
      Infiltration Cellular, Mixed Cell    |                         1                             3                  |      5  2.0|
      Mixed Cell Focus                     |                   X                                                      |      2     |
      Necrosis, Coagulative, Multifocal    |                                                                4  3      |      3  3.7|
      Thrombosis                           |                                                                          |      1  4.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                 +                                    |   3        |
      Fat, Necrosis                        |                                     3                                    |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |    2                                2  1        1        1               |      7  1.6|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ulcer                                |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Dysplasia                            |                                                                          |      1  1.0|
      Peridontal Tissue, Proliferation     |                                                                          |            |
          Connective Tissue                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5|     |            |
                             DAY ON TEST   | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9|     |            |
                                           | 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    312 PPM                                | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|     |      L     |
                                           | 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3|     |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia                          | 3                                                        1               |      3  2.0|
      Capsule, Hyperplasia                 | 1     1           1        2        2  1  1              1               |     26  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hyperplasia                          |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  M  +  +  +  +  +  +  +  +  +  M  M  M  +  M  +  M  +  M      |  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M      |  44        |
      Pars Distalis, Cyst                  |                                                          X               |      1     |
      Pars Distalis, Hyperplasia           |                                                          1               |      1  1.0|
      Pars Intermedia, Hemorrhage          |                               4                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ultimobranchial Cyst                 |                                     X                                    |      1     |
      Follicle, Cyst                       |                                                 X                        |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                   +                                      +               |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Ectasia                              |       3                                                                  |      2  3.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                            1                                   2         |      5  1.4|
      Inflammation, Chronic                |                                     2           3                        |      5  2.2|
      Inflammation, Suppurative            |                                                                          |      4  3.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Dilatation                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5|     |            |
                             DAY ON TEST   | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9|     |            |
                                           | 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    312 PPM                                | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|     |      L     |
                                           | 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  M  +  +  +  +  +  M  M  +  +  M  +  +  M  +  +  +  M  +  +  +      |  36        |
      Hemorrhage                           |                      2                                         2         |      2  2.0|
      Hyperplasia, Lymphoid                |                   3                                   2                  |      2  2.5|
      Pigmentation, Hemosiderin            |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  M  M  I  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +  M  +      |  34        |
      Congestion                           |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic             |                                                       2                  |      1  2.0|
      Hyperplasia, Lymphoid                |                   2                                                      |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | I  I  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M      |  42        |
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia, Histiocytic             |                                                       2                  |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  M  M  +  +  M  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +      |  34        |
      Congestion                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |       3                                                                  |      1  3.0|
      Hematopoietic Cell Proliferation     | 2  2     3  3  2  2  3  3        3     3  3        2  3  3     3  3      |     32  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation, Melanin                |                               1                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  I  +  +  M  +  +  +  +      |  40        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  M      |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Chronic                |                3                                                         |      4  3.0|
      Ulcer                                |                3                                                         |      4  3.5|
      Prepuce, Acanthosis                  |                                                                          |      2  2.0|
      Prepuce, Inflammation, Chronic       |                                                                          |      2  4.0|
      Prepuce, Pigmentation, Melanin       |                                                                          |      1  3.0|
      Prepuce, Ulcer                       |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Hemorrhage                           |                               2                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 5| 4| 5| 6| 5| 5| 5| 6| 0| 5| 6| 6| 5| 5| 6| 5| 5| 6| 4| 4| 5|     |            |
                             DAY ON TEST   | 3| 9| 3| 6| 9| 4| 8| 0| 5| 6| 7| 1| 6| 6| 6| 3| 6| 9| 3| 6| 6| 9| 9|     |            |
                                           | 7| 3| 7| 2| 3| 6| 6| 8| 2| 6| 7| 3| 6| 6| 6| 7| 6| 9| 7| 6| 3| 5| 0|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     |      A     |
    312 PPM                                | 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|     |      L     |
                                           | 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 9| 2| 3|     |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       | 2        1  2     2        2     2  2  1     2  2  2                     |     19  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Congestion                           |                         3                                                |      2  3.0|
      Crystals                             |                3                                                         |      1  3.0|
      Hemorrhage                           |       1                          3                          2            |      4  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                4                                3        3               |      5  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Proliferation Connective Tissue,     |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                          +           +           +        +            |   8        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                        1                                 |      1  1.0|
      Nephropathy                          |             1        1  1  1                          1                  |     12  1.0|
      Renal Tubule, Dilatation             |                                        1                                 |      4  1.0|
      Renal Tubule, Karyomegaly            |                                                 1                        |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  A  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +      |  43        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|             
                             DAY ON TEST   | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|             
                                           | 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  +  A  +  M  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  M  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  A  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  A  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                 4                       4              3           2   |             
      Basophilic Focus                     |                X                                                        X|             
      Eosinophilic Focus                   |                               X     X     X                              |             
      Hematopoietic Cell Proliferation     |                         2                          4     4               |             
      Infarct                              |                         3  4                                             |             
      Infiltration Cellular, Mixed Cell    |                               2  3                                       |             
      Mixed Cell Focus                     |          X                             X                                 |             
      Necrosis, Coagulative, Multifocal    |                         3  3           1     2  2     3     4  1     4  3|             
      Thrombosis                           |    4                                               4     4               |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Duct, Ectasia                        |                                                             3            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma                            |          3                                                               |             
      Hyperplasia, Squamous                |                                                    4                     |             
      Epithelium, Hyperplasia              |                            2                 2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +              +                                       |             
      Inflammation, Suppurative            |                   3              3                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                        1  2                              |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |       2           1     1     2        2        2  2     1  1     1  2   |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    3              2              2     2                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  M  M  +  +  M  M  +  +  +  +  M  M  +  M  M  I  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|             
                             DAY ON TEST   | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|             
                                           | 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                            X                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                  X                                       |             
      Follicle, Cyst                       |                   X                                                      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                                                                        |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Necrosis                             | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   2      |             
      Ectasia                              |                                                    2                     |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |       2     2           2                 1                       1      |             
      Inflammation, Chronic                |                                                          3               |             
      Inflammation, Suppurative            |                   4                 4           3                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                               2                                          |             
      Inflammation, Suppurative            |                                                          3               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation, Chronic                |                               3                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                          3               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                             +                                    |             
      Iliac, Hemorrhage                    |                                     2                                    |             
      Iliac, Hyperplasia, Plasma Cell      |       3                             2                                    |             
      Iliac, Pigmentation, Hemosiderin     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  +  +  +  +  +  +  M  M  +  +  M  M  +  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  I  M  +  M  +  +  +  +  +|             
      Hyperplasia, Histiocytic             |                                                             2            |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Pigmentation, Hemosiderin            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|             
                             DAY ON TEST   | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|             
                                           | 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
      Hematopoietic Cell Proliferation     |                                     2                                    |             
      Hemorrhage                           |    3                                                                     |             
      Hyperplasia, Lymphoid                |                                        3                                 |             
      Inflammation, Chronic Active         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  M  +  +  M  +  M  M  M  +  +  +  M  +  M  +  +  +  +  +  M  +  I|             
      Hematopoietic Cell Proliferation     |                                     3                                    |             
      Hemorrhage                           |                                                       1     2            |             
      Hyperplasia, Histiocytic             |                                                    2                     |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  3  3  3  3     2  3  3  3  2  3  3  3  3  3  3  3  3  3  3  3     3   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  M  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  M  +  M|             
      Mineralization                       |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   1      |             
      Inflammation, Chronic                |                                     2                       2            |             
      Prepuce, Ulcer                       |                                                          4               |             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       2  2        2        1  2  2              2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Mucopurulent                |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Hemorrhage                           |             3                                                            |             
      Pigmentation, Hemosiderin            |             3                                                            |             
      Alveolar Epithelium, Hyperplasia     |          1                                                               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                  2                                       |             
      Vomeronasal Organ, Hypertrophy       |                                  3                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 4| 5| 6| 5| 4| 5| 6| 5| 6| 6| 5| 5| 5| 5| 5| 5| 6| 4| 5| 6| 4| 4| 6| 4|             
                             DAY ON TEST   | 3| 8| 8| 3| 4| 9| 5| 5| 1| 6| 6| 9| 6| 4| 4| 5| 7| 1| 1| 3| 3| 3| 4| 5| 8|             
                                           | 9| 5| 9| 1| 1| 7| 1| 3| 7| 6| 6| 7| 9| 1| 8| 4| 3| 8| 5| 1| 9| 3| 7| 7| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    625 PPM                                | 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6|             
                                           | 3| 4| 6| 8| 0| 1| 2| 3| 4| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                          +      |             
      Degeneration, Diffuse                |                                        4                                 |             
      Phthisis Bulbi                       |                                                                   3      |             
      Retinal Detachment                   |                                        4                                 |             
      Cornea, Inflammation, Chronic        |                                        3                                 |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +     +                    +     +|             
      Hyperplasia                          |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             X            |             
      Inflammation, Chronic Active         |                                                          2               |             
      Nephropathy                          |    2                       1  1        2                                 |             
      Renal Tubule, Dilatation             | 1        1     1  1  1        1  1           1              1        1   |             
      Renal Tubule, Karyomegaly            |       1  1     1           1  1     1  1           1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6|     |            |
                             DAY ON TEST   | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4|     |            |
                                           | 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  M  +  +  +  +  +  +  +  +  A  M  A  A  +  A  +  +  +  A  +  A  +      |  31        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  A  A  A  +  +  +  +  +  +  +  +  +      |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  +  +  +  I  +      |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  A  A  A  A  +  A  +  +  +  +  +  A  +      |  36        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  A  A  +  +  +  +  +  +  +  A  +  A  A  +  A  +  +  +  A  +  A  +      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  A  A  +  +  +  +  +  +  +  A  A  A  A  +  A  +  +  +  +  +  A  +      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  A  +  +  +  +  +  +  +  A  A  A  A  +  A  +  +  +  +  +  A  +      |  35        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |          3           1  1                 2        3                     |     10  2.5|
      Basophilic Focus                     |    X                                            X                        |      4     |
      Eosinophilic Focus                   |                   X  X        X              X                           |      7     |
      Hematopoietic Cell Proliferation     |                                                       3                  |      4  3.3|
      Infarct                              |                                                                          |      2  3.5|
      Infiltration Cellular, Mixed Cell    |                      3                                                   |      3  2.7|
      Mixed Cell Focus                     |                                                    X                     |      3     |
      Necrosis, Coagulative, Multifocal    | 2                                         3                    4         |     13  2.7|
      Thrombosis                           |                                                                          |      3  4.0|
      Centrilobular, Necrosis              |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   2        |
      Fat, Necrosis                        |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
      Granuloma                            |                                                                          |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      1  4.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                     +               |   4        |
      Inflammation, Suppurative            |    2                                                     4               |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cardiomyopathy                       |                                                                          |      2  1.5|
      Infiltration Cellular, Mixed Cell    |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6|     |            |
                             DAY ON TEST   | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4|     |            |
                                           | 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0|     |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Capsule, Hyperplasia                 |    1     2  1        1     2     1  1  1     1     1  1     2  1         |     24  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
      Hyperplasia                          |                      2                    2                    2         |      7  2.1|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  M  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  I  +  M  +      |  29        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +      |  44        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                              +                           |   2        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                              3                           |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Atrophy                              |                                                                          |      1  2.0|
      Ectasia                              |                                                                          |      1  2.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                      2                                      1            |      7  1.6|
      Inflammation, Chronic                |          3     2  2                                                      |      4  2.5|
      Inflammation, Suppurative            |             4                          3           4              4      |      7  3.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  M  +  +  +  +  +  +  +  A  M  A  +  +  +  +  +  +  +  +  +  +      |  44        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +      |  47        |
      Dilatation                           |                   3           3                                          |      2  3.0|
      Inflammation, Chronic                |                   3                                                      |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy, Focal                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia, Neutrophil              |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6|     |            |
                             DAY ON TEST   | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4|     |            |
                                           | 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   2        |
      Iliac, Hemorrhage                    |                                                                          |      1  2.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      2  2.5|
      Iliac, Pigmentation, Hemosiderin     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  +  +  +  +  +  +  A  +  +  +  M  +  I  +  +  M  +      |  35        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +  M  +  +  M  M  +  +  M  +  +  M  +  M  +  +  I  +  I      |  32        |
      Hyperplasia, Histiocytic             |                                                 2                        |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Pigmentation, Hemosiderin            |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  M  +  +  +  +      |  41        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                          3               |      2  3.0|
      Hyperplasia, Lymphoid                | 2                                                                        |      2  2.5|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  I  +  +  +  +  +  +  +  +  +  A  M  +  M  +  +  M  +  +  +  M      |  32        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hemorrhage                           |                                                             2            |      3  1.7|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
      Hematopoietic Cell Proliferation     | 2  3     3  3  3  3  2  3  3     3     4  2  2     3  3  2  4  3  2      |     41  2.9|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  M  +  +  +  +  A  M  +  M  M  +  +  M  +  +  +      |  34        |
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M      |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Atrophy                              |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Prepuce, Ulcer                       |                                                                          |      1  4.0|
      Subcutaneous Tissue, Hemorrhage      |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mineralization                       |                      2  2     2                       1  1        1      |     13  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 5| 5| 5| 6| 5| 6| 6| 6| 5| 6| 3| 5| 6| 5| 3| 5| 5| 4| 5| 6| 6|     |            |
                             DAY ON TEST   | 2| 1| 1| 8| 9| 0| 4| 0| 4| 0| 4| 1| 6| 0| 0| 1| 6| 4| 1| 4| 8| 3| 4|     |            |
                                           | 0| 6| 6| 9| 3| 8| 8| 8| 9| 7| 7| 5| 3| 9| 0| 8| 8| 1| 8| 6| 6| 2| 6|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     |      A     |
    625 PPM                                | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 9|     |      L     |
                                           | 2| 3| 4| 5| 6| 7| 0| 1| 3| 4| 6| 7| 8| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0|     |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
      Exudate, Mucopurulent                |                                              2  4                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Congestion                           |    3  3                                2                       2         |      5  2.6|
      Hemorrhage                           |                                                       2                  |      2  2.5|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
      Inflammation, Suppurative            |                                                 3        3               |      3  2.7|
      Vomeronasal Organ, Hypertrophy       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +      |  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Degeneration, Diffuse                |                                                                          |      1  4.0|
      Phthisis Bulbi                       |                                                                          |      1  3.0|
      Retinal Detachment                   |                                                                          |      1  4.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                             +            |   5        |
      Hyperplasia                          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Nephropathy                          |             1     1  1     1           1           1                     |     10  1.2|
      Renal Tubule, Dilatation             |    1                 1  1                                   1  1  1      |     16  1.0|
      Renal Tubule, Karyomegaly            |                      1  1                                                |     10  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +      |  43        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|             
                             DAY ON TEST   | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|             
                                           | 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  A  +  +  M  +  +  +  +  +  +  M  A  M  A  +  A  M  M  A  M  M  +  A  +|             
      Inflammation, Chronic Active         |                      3                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  A  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  +  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  A  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  A  A  A  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  A  A  A  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             1     3                                         3  3         |             
      Basophilic Focus                     |                   X                                      X               |             
      Eosinophilic Focus                   |                                                    X        X            |             
      Hemorrhage                           |                                                                          |             
      Infarct                              |                                                                         4|             
      Infiltration Cellular, Mixed Cell    |                   3                                1                     |             
      Necrosis, Coagulative, Multifocal    |       1  4     3              2     3                       3        2   |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Regeneration             |                                                             4            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +  +        +                                       |             
      Angiectasis                          |                                                                          |             
      Fat, Hemorrhage                      |                      2  1                                                |             
      Fat, Necrosis                        |                      2           3                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                            2                                             |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Epithelium, Hyperplasia              |                            2                 1                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Necrosis                             |                2                    3                                    |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +  +                                                     +         |             
      Dysplasia                            |       3  2                                                               |             
      Inflammation, Suppurative            |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 1        1        1     1  1  1  1     1  1           1  1        1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  58                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|             
                             DAY ON TEST   | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|             
                                           | 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                                        2         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma Sperm                      |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                      2                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                3                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Neutrophil              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  M  M  M  M  M  +  +  M  +  +  +  +  +  M  I  +  +  M  M  +  I  M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  M  +  +  +  M  M  +  +  +  M  M  M  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  M  M  +  +  +|             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  M  M  +  M  +  I  M  +  M  +  +  M  M  +  +  M  +|             
      Hemorrhage                           |       1                                                                  |             
      Hyperplasia, Histiocytic             |                2                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4     4  4     4  3  3  3  3  3  3  3  3  2        2  3  3  2  4  3  3  2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  M  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             3                                                            |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |             3                                      3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|             
                             DAY ON TEST   | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|             
                                           | 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Prepuce, Inflammation, Suppurative   |                                                                          |             
      Subcutaneous Tissue, Congestion      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture                             |                                                                          |             
      Sternum, Developmental Malformation  |                X                                                         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1              2  1     2  1     2  2     2              2  1     2  1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate, Mucopurulent                |                                                                      X   |             
      Hemorrhage                           |                                                                      2   |             
      Metaplasia, Squamous                 |                                              1                           |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           2                              |             
      Hemorrhage                           |                                                                         2|             
      Infarct                              |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                        3                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Respiratory Epithelium, Degeneration |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                       +                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                                       |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                   2                                                      |             
      Nephropathy                          | 1     1  1     1     1                 1           1        1           1|             
      Renal Tubule, Dilatation             | 2     1  1  1     1     1  1  1  1  1     1     2  2     2  1  1  2  1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 3| 4| 5| 6| 5| 5| 6| 6| 6| 5| 6| 5| 6| 5| 2| 5| 5| 6| 6| 5| 5| 6| 5| 5|             
                             DAY ON TEST   | 4| 5| 8| 4| 0| 8| 4| 6| 0| 0| 8| 1| 9| 2| 4| 5| 6| 1| 1| 0| 5| 5| 2| 4| 8|             
                                           | 3| 6| 3| 3| 8| 3| 1| 6| 0| 8| 9| 3| 9| 9| 8| 9| 3| 8| 3| 0| 1| 9| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1250 PPM                               | 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
                                           | 9| 2| 4| 5| 7| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Renal Tubule, Karyomegaly            | 1     1  1  1     1     1  1     1  1  1           1  1  1  1           1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6|     |            |
                             DAY ON TEST   | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3|     |            |
                                           | 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|     |      L     |
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  M  M  +  M  +  +  +  +  +  A  +  +  A  M  +  +      |  27        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +      |  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  A  +  +      |  36        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  A  +  +  A  A  +  +      |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  A  +  +      |  36        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Angiectasis                          |             2     4        3        2  4  3        2        2  2         |     13  2.6|
      Basophilic Focus                     |                                                             X            |      3     |
      Eosinophilic Focus                   |       X     X                          X        X  X                     |      7     |
      Hemorrhage                           |                4                                                         |      1  4.0|
      Infarct                              |    2                          4                       3                  |      4  3.3|
      Infiltration Cellular, Mixed Cell    |                                              2                           |      3  2.0|
      Necrosis, Coagulative, Multifocal    |             2                       3        2              1            |     11  2.4|
      Centrilobular, Necrosis              |                                  3                                       |      1  3.0|
      Hepatocyte, Regeneration             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +     +                 +                                +            |   7        |
      Angiectasis                          |                            3                                             |      1  3.0|
      Fat, Hemorrhage                      |                                                                          |      2  1.5|
      Fat, Necrosis                        |                                                             2            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             | 2                          2                                             |      3  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Ulcer                                |                3                                                         |      1  3.0|
      Epithelium, Hyperplasia              |          2                                                               |      3  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Foreign Body                         |                               3                                          |      1  3.0|
      Necrosis                             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   | +  +                                            +        +               |   7        |
      Dysplasia                            |    3                                                                     |      3  2.7|
      Inflammation, Suppurative            | 2                                               3        2               |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6|     |            |
                             DAY ON TEST   | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3|     |            |
                                           | 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|     |      L     |
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Capsule, Hyperplasia                 | 1  1        1  1  2                          2  2                 2      |     20  1.2|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  45        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  M  M  +  M  +  +  +  M  +  +  +  +  +  +      |  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +      |  44        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Granuloma Sperm                      |                                              3                           |      1  3.0|
      Hemorrhage                           |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                   2     1                                                |      3  1.7|
      Inflammation, Chronic                |                                                    3                     |      1  3.0|
      Inflammation, Suppurative            |                                              2                    3      |      3  2.7|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  44        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Hyperplasia, Neutrophil              |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  M  I  M  +  +  A  +  +  +  +  M  +  M  +  M  +  +  M      |  26        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +      |  34        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  A  M  +  +  +  +  +  +  +  +  +  +  +      |  40        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  +  M  +  M  +  +  +  +  M  +  +  +  +  +  M  M  I  M  +  +  M      |  29        |
      Hemorrhage                           |                                                             2            |      2  1.5|
      Hyperplasia, Histiocytic             |                                                             2            |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  63                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6|     |            |
                             DAY ON TEST   | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3|     |            |
                                           | 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|     |      L     |
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Hematopoietic Cell Proliferation     | 3  2  3  3  3  4  3  1  3  3  3  4  3  2  3  3  4  3        4  3  3      |     42  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  M  +  +  +  M  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +      |  37        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M      |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Inflammation, Chronic                |                            2                 2                           |      3  2.3|
      Inflammation, Suppurative            |                   3                                                      |      1  3.0|
      Ulcer                                |                   3        3                 2                           |      5  2.8|
      Prepuce, Inflammation, Suppurative   |                                                    3                     |      1  3.0|
      Subcutaneous Tissue, Congestion      |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Fracture                             |                         X                                                |      1     |
      Sternum, Developmental Malformation  |                                                                   X      |      2     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                +         |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Mineralization                       |    1     1  1              2  1  1  2        1        1     1     2      |     24  1.4|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
      Exudate, Mucopurulent                |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |                      1                                                   |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infarct                              |                                                                4         |      1  4.0|
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  47        |
      Inflammation, Suppurative            |                                                          1               |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                     3                                    |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05132-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                     TETRAFLUOROETHYLENE  (TFE)                                Date: 09/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 19:26:30  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 5| 5| 6| 5| 5| 4| 3| 6| 4| 5| 5| 5| 5| 5| 6| 5| 5| 0| 5| 6| 6|     |            |
                             DAY ON TEST   | 0| 3| 4| 4| 1| 2| 8| 0| 1| 4| 6| 7| 2| 7| 7| 8| 5| 4| 3| 0| 6| 0| 3|     |            |
                                           | 8| 0| 1| 8| 0| 7| 5| 1| 5| 6| 5| 8| 7| 5| 4| 6| 4| 1| 6| 5| 5| 6| 1|     |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4|     |      A     |
    1250 PPM                               | 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0|     |      L     |
                                           | 1| 2| 3| 4| 6| 7| 9| 0| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6|     |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Degeneration |                                                          1               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  46        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                +         |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +                          +     +                                    |   6        |
      Hyperplasia                          | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +      |  48        |
      Cyst                                 |                                                                          |      1     |
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  2.0|
      Nephropathy                          |          1     1  1        1                 1  1  2                     |     16  1.1|
      Renal Tubule, Dilatation             | 1  2     1  1  1  2  1  2  2     2     1  2  2     1  1     1     1      |     36  1.4|
      Renal Tubule, Karyomegaly            | 1  1     1  1  1  1  1     1     1     1  1        1  1                  |     28  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +      |  42        |
      Inflammation, Chronic Active         |                                                    3                     |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
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                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------