Share This:
https://ntp.niehs.nih.gov/go/1360

TDMS Study 05106-01 Pathology Tables

NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97
Route: SKIN APPLICATION                                                                                           Time: 16:40:05




       Facility:  Hazleton, Maryland

       Chemical CAS #:  84-66-2

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 3| 3| 3| 1| 9| 5| 7| 3| 3| 3| 5| 0| 5| 3| 3|             
                                           | 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 4| 4| 4| 7| 3| 2| 9| 4| 4| 4| 0| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +     +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +|             
      Mucosa, Atrophy                      |                                                             3            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +     +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  +  +|             
      Mucosa, Atrophy                      |                                                             3            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                               X  X  X        X                       X   |             
      Clear Cell Focus                     |                                                          X               |             
      Degeneration, Fatty                  |                                  2                    1  2           1   |             
      Hepatodiaphragmatic Nodule           |                            X  X     X                    X               |             
      Inflammation, Chronic, Focal         |                                  2  2                 2              1  2|             
      Inflammation, Focal, Granulomatous   | 2     1  2     1  2                                                      |             
      Mixed Cell Focus                     |                                     X                                    |             
      Necrosis                             |                                                       3           1      |             
      Bile Duct, Hyperplasia               |    2     1     2  2  1  1        3  2  4  2  2  3  2     2  2  2         |             
      Centrilobular, Degeneration, Fatty   |                                                             3            |             
      Midzonal, Degeneration, Fatty        |                                                                   2      |             
      Peripheral, Degeneration, Fatty      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Fat, Granuloma                       |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Acinus, Atrophy                      |                            2     1                 1                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                        3        3        3  2     2  2   |             
      Edema                                |                                        2        4           2     2      |             
      Hemorrhage                           |                                                                   3      |             
      Hyperkeratosis                       |                                        3        3        3  2     3      |             
      Ulcer                                |                                                          4  3            |             
      Serosa, Inflammation, Proliferative  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Erosion, Focal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 3| 3| 3| 1| 9| 5| 7| 3| 3| 3| 5| 0| 5| 3| 3|             
                                           | 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 4| 4| 4| 7| 3| 2| 9| 4| 4| 4| 0| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2        2           1  1     2  2  2     2  1  2  1  2  2  1  2  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Degeneration, Fatty, Focal           |             1                                   3           3     1  2   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                1  1     2        2                       2  2     1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                               2                          3               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Cyst                  |                   X                                                      |             
      Pars Distalis, Hyperplasia, Focal    |       1           1        1                                            1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +     +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Ectasia                              |                                                                      2   |             
      Fibrosis                             |                                                                          |             
      Granuloma                            |                                                             3            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                  4                                2      |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                             2            |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Endometrium, Atrophy                 |                                     2  3  2  2        2     2  3  4  2   |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 3| 3| 3| 1| 9| 5| 7| 3| 3| 3| 5| 0| 5| 3| 3|             
                                           | 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 4| 4| 4| 7| 3| 2| 9| 4| 4| 4| 0| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematocyst                           |                                                                          |             
      Hematopoietic Cell Proliferation     |             4                 3  2  2              2  2  2           2  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            | 2  2  2  2     3  2  2  2           2     2                    3  2     2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +     +  +  +  +  +  +  M  I  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |    X                                                                     |             
      Depletion Lymphoid                   |                                                             2     1      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Cystic                  | 2  3  4        3  3     4  3                                             |             
      Hyperplasia                          |                                     2                    3              3|             
      Lactation                            |                               X  X  X     X  X  X  X  X  X  X     X  X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Acanthosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                              1                 2         |             
      Ulcer                                |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                  X           X     X                     |             
      Cerebrum, Compression                |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis, Focal                   |       2                                                                  |             
      Congestion                           |                                     2     3  3                 3  2  2  2|             
      Hemorrhage                           |                                                             1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 3| 4| 4| 4| 4| 4| 7| 7| 7| 7| 5| 5| 6| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 3| 5| 5| 5| 5| 5| 3| 3| 3| 1| 9| 5| 7| 3| 3| 3| 5| 0| 5| 3| 3|             
                                           | 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 4| 4| 4| 7| 3| 2| 9| 4| 4| 4| 0| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                          2               |             
      Inflammation, Chronic                |                                                 3     2                  |             
      Alveolar Epithelium, Hyperplasia     |                                                       2                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                   1                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                        X                                 |             
      Inflammation, Chronic                |                                                                         2|             
      Inflammation, Suppurative            |             4                                               2            |             
      Nares, Ulcer                         |                                                                          |             
      Nasolacrimal Duct, Exudate           |       2                    2                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |          +  +                 +  +  +  +        +  +  +  +  +  +  +  +  +|             
      Cataract                             |          2  3                 2  2  3  3        3  3  3  3  2  3  3  3  3|             
      Hemorrhage                           |                                                                          |             
      Inflammation                         |                                                                          |             
      Cornea, Inflammation                 |                                                                          |             
      Retina, Atrophy                      |          3  3                 2  2  3  3           3  2  2  2  2  3  2  2|             
      Retrobulbar, Hemorrhage              |          3                                                               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                          +               |             
      Cyst                                 |                                                          X               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |             2                                                            |             
      Nephropathy                          |    1  2  1           2  3     3  3  2     2  3  2  2  1  3  2  1  3  2  2|             
      Cortex, Mineralization, Focal        |       2                 2  1                                             |             
      Pelvis, Dilatation                   |                               2                                          |             
      Pelvis, Epithelium, Hyperplasia      |                1  2  2              1           2  2     1               |             
      Pelvis, Epithelium, Mineralization,  |                                                                          |             
           Focal                           |                2  2  2                                                   |             
      Pelvis, Epithelium, Mineralization   |                                           2        2  2                  |             
      Perirenal Tissue, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis                        |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5| 3| 3| 3| 5| 6| 3| 3|             
                                           | 4| 4| 4| 9| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 5| 8| 4| 4| 4| 1| 2| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 UL/RAT                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         X                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X        X  X     X              X        X        X     X            |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Fatty                  | 3     1           3        2     2        2           2  2     2         |             
      Hepatodiaphragmatic Nodule           |    X        X                    X                    X                  |             
      Inflammation, Chronic, Focal         | 2  2        3  2  2     2           2  2  2  2        1  2  2     1     2|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2     2     1     2  2  2              2     2        2     3  1     2|             
      Centrilobular, Degeneration, Fatty   |                                                    3                 3   |             
      Midzonal, Degeneration, Fatty        |          3                                                               |             
      Peripheral, Degeneration, Fatty      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                     +         |             
      Fat, Granuloma                       |          3                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                4         |             
      Acinus, Atrophy                      | 2  3                                2  2  2                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          3     3                             3     4           2     3   |             
      Edema                                |                                                                2         |             
      Hemorrhage                           |                                                                2         |             
      Hyperkeratosis                       |          4     2                             2     4           3         |             
      Ulcer                                |          3                                                           3   |             
      Serosa, Inflammation, Proliferative  |                                                    3                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Erosion, Focal               |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5| 3| 3| 3| 5| 6| 3| 3|             
                                           | 4| 4| 4| 9| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 5| 8| 4| 4| 4| 1| 2| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 UL/RAT                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  2     3  2  2  2  1  2  2  2  2  2  2  3        2  1  1  1  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Degeneration, Fatty, Focal           |    2     2           2        2  2              2                 2      |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Hyperplasia, Focal                   |          2                                                              3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                  2                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +|             
      Hypertrophy                          |          1  2                                                           2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          2                             4                                 |             
      Hemorrhage                           |                      2                                                   |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |             3                                2              2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2        2              2                                         2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                   +                                +                     |             
      Abscess                              |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +|             
      Ectasia                              |    3              3                                      3               |             
      Fibrosis                             |                                  2        2                              |             
      Granuloma                            |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                           2                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |             X                                                            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                   2                                                      |             
      Endometrium, Atrophy                 |       2     2  2              2     2           4                    2  2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5| 3| 3| 3| 5| 6| 3| 3|             
                                           | 4| 4| 4| 9| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 5| 8| 4| 4| 4| 1| 2| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 UL/RAT                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematocyst                           |                                                    X                     |             
      Hematopoietic Cell Proliferation     | 2  2        3  1           2  3     2     2  2        1  2  2           2|             
      Hyperplasia, Lymphoid                |                               3                                          |             
      Pigmentation, Hemosiderin            | 2     2                    2        2        2                    2     2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |                                        X                                 |             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |       3     3                 3              3                       3  3|             
      Lactation                            | X  X  X  X  X  X  X     X  X  X  X  X     X     X  X  X  X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Acanthosis                    |                               2              2                           |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    2  2                                                                  |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                   2     1                             1  1              1|             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                               X                                          |             
      Hyperostosis                         |                                              X                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                         X|             
      Cerebrum, Compression                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis, Focal                   |                                                                          |             
      Congestion                           |    2  2                    2        3                       1     3      |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 5| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 3| 3| 6| 3| 3| 3| 3| 2| 3| 3| 3| 5| 5| 3| 3| 3| 5| 6| 3| 3|             
                                           | 4| 4| 4| 9| 4| 4| 4| 9| 4| 4| 4| 4| 4| 4| 4| 4| 5| 8| 4| 4| 4| 1| 2| 1| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0 UL/RAT                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                 1                        |             
      Inflammation, Chronic                |                            2        2        2  2              2         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                  X        X                              |             
      Inflammation, Chronic                | 2     2     2     2        2                 2        2     2           2|             
      Inflammation, Suppurative            |                                        3                                 |             
      Nares, Ulcer                         |          3                                                               |             
      Nasolacrimal Duct, Exudate           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +|             
      Cataract                             | 2  3  3  2  3  3  2  3  3  2  3  3  3  3  3  3  3     3  3  2  3     3  3|             
      Hemorrhage                           |             2                    2                    2  2               |             
      Inflammation                         |                                                          3               |             
      Cornea, Inflammation                 |                               3  2                                       |             
      Retina, Atrophy                      | 2  3  2  2  3  2  2  2  2  3  2  3  2  3  3  3  2        3  2        3  2|             
      Retrobulbar, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Nephropathy                          | 2  2  3  2  2  2  3     2  3  4  2  2     2  2  2  2  3  2  2  2  2  2  3|             
      Cortex, Mineralization, Focal        |                                                                          |             
      Pelvis, Dilatation                   |                                                 2              2         |             
      Pelvis, Epithelium, Hyperplasia      | 2  2        1  2           2  3  1     2  1  2  2  2        1           2|             
      Pelvis, Epithelium, Mineralization,  |                                                                          |             
           Focal                           |                                                                          |             
      Pelvis, Epithelium, Mineralization   | 2  2        1                 1  1     2  1        2        2           1|             
      Perirenal Tissue, Inflammation,      |                                                                          |             
          Suppurative                      |                                        3                                 |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis                        |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                      3   |             
      Renal Tubule, Mineralization         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 4| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1|                                            |            |
                                           | 5| 5| 5| 5| 3| 0| 5| 4| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperkeratosis                       |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +                                             |  55        |
      Mucosa, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +                                             |  55        |
      Mucosa, Atrophy                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |       2                                                                  |      1  2.0|
      Basophilic Focus                     |    X     X           X                                                   |     16     |
      Clear Cell Focus                     | X                                                                        |      2     |
      Degeneration, Fatty                  |                         2                                                |     14  1.9|
      Hepatodiaphragmatic Nodule           |                                                                          |      8     |
      Inflammation, Chronic, Focal         | 2  1  2  2           1                                                   |     25  1.8|
      Inflammation, Focal, Granulomatous   |                                                                          |      5  1.6|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               | 2  1  2              2                                                   |     33  2.0|
      Centrilobular, Degeneration, Fatty   |                                                                          |      3  3.0|
      Midzonal, Degeneration, Fatty        |                            4                                             |      3  3.0|
      Peripheral, Degeneration, Fatty      |                3  3  2                                                   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Granuloma                       |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fibrosis                             |                                                                          |      1  4.0|
      Acinus, Atrophy                      |                1     3                                                   |     10  1.9|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acanthosis                           |                3  1     3  4                                             |     16  2.8|
      Edema                                |                            2                                             |      6  2.3|
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperkeratosis                       |                3  1     3  4                                             |     14  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 4| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1|                                            |            |
                                           | 5| 5| 5| 5| 3| 0| 5| 4| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                2        2  3                                             |      7  2.9|
      Serosa, Inflammation, Proliferative  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mucosa, Erosion, Focal               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cardiomyopathy                       | 1  3  2  1  2        2  2                                                |     47  1.7|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Degeneration, Fatty, Focal           |    3                 1  3                                                |     15  2.1|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Focal                   | 2     2  2                 2                                             |     13  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +                                             |  54        |
      Hypertrophy                          |                   2     2                                                |      7  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |       3              3                                                   |      4  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      7  1.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      C-Cell, Hyperplasia                  |          2  2        2                                                   |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Abscess                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +                                             |  53        |
      Ectasia                              |    2  2                                                                  |      6  2.5|
      Fibrosis                             |                2                                                         |      3  2.0|
      Granuloma                            |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 4| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1|                                            |            |
                                           | 5| 5| 5| 5| 3| 0| 5| 4| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |                                                                          |      1  2.0|
      Endometrium, Atrophy                 |    2     2     2     2  2  3                                             |     23  2.3|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hypoplasia                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematocyst                           |                                                                          |      1     |
      Hematopoietic Cell Proliferation     | 1  2  2  2  2  2  3  3                                                   |     30  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |                3  2     2  2                                             |     24  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Cyst                                 |                                                                          |      2     |
      Depletion Lymphoid                   |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Cystic                  |                                                                          |      7  3.1|
      Hyperplasia                          |                                                                          |      9  2.9|
      Lactation                            | X  X  X  X  X  X  X  X  X  X                                             |     44     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Other, Acanthosis                    |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acanthosis                           |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acanthosis                           | 2                                                                        |      8  1.4|
      Ulcer                                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 4| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1|                                            |            |
                                           | 5| 5| 5| 5| 3| 0| 5| 4| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Fibrous Osteodystrophy               |                                                                          |      1     |
      Hyperostosis                         |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Compression                          |                X  X        X                                             |      7     |
      Cerebrum, Compression                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atelectasis, Focal                   |                                                                          |      1  2.0|
      Congestion                           |    2     2  3           2  3                                             |     18  2.3|
      Hemorrhage                           |                                                                          |      1  1.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  1.5|
      Inflammation, Chronic                |                      2                                                   |      8  2.1|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fungus                               |                                                                          |      3     |
      Inflammation, Chronic                |                                                                          |     10  2.0|
      Inflammation, Suppurative            |                                                                          |      3  3.0|
      Nares, Ulcer                         |                                                                          |      1  3.0|
      Nasolacrimal Duct, Exudate           |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +     +  +  +                                             |  47        |
      Cataract                             | 3  3  3  3  3  3     3  3  3                                             |     48  2.8|
      Hemorrhage                           |             3                                                            |      5  2.2|
      Inflammation                         |                                                                          |      1  3.0|
      Cornea, Inflammation                 |                                                                          |      2  2.5|
      Retina, Atrophy                      | 2  2     3     3     2     2                                             |     41  2.4|
      Retrobulbar, Hemorrhage              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Cyst                                 |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 4| 7| 6| 6|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 6| 3| 5| 1|                                            |            |
                                           | 5| 5| 5| 5| 3| 0| 5| 4| 6| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      A     |
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     UF                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Nephropathy                          | 1  3  2  2  2  3  3  1  4  3                                             |     52  2.3|
      Cortex, Mineralization, Focal        |                                                                          |      3  1.7|
      Pelvis, Dilatation                   |                                                                          |      3  2.0|
      Pelvis, Epithelium, Hyperplasia      |                2                                                         |     22  1.7|
      Pelvis, Epithelium, Mineralization,  |                                                                          |            |
           Focal                           |                                                                          |      3  2.0|
      Pelvis, Epithelium, Mineralization   |       1                                                                  |     14  1.6|
      Perirenal Tissue, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis                        |             3                                                            |      1  3.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Pigmentation                    |                                                                          |      1  3.0|
      Renal Tubule, Mineralization         |    2                                                                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +                                             |  57        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 4| 7| 5| 7| 7| 6| 7| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 5| 1| 3| 6| 3| 3| 4| 3| 3| 3| 7| 5| 4|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 9| 5| 8| 5| 5| 5| 5| 5| 5| 3| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                               2                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +  +  +  A  +  +  +  +  +  +  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Edema                                |                               3                                          |             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Erosion, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +  +  +  M  +  +  +  +  +  +  +  +  A  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +  +  +  +  +  +  +  +  +  +  +  +  A  A  A|             
                                            __________________________________________________________________________|             
   Liver                                   |                   +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    3           2         |             
      Basophilic Focus                     |                                                    X     X        X      |             
      Clear Cell Focus                     |                                                                X         |             
      Congestion                           |                                                                          |             
      Degeneration, Fatty                  |                                                 3                        |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                           X     X           X            |             
      Inflammation, Chronic, Focal         |                                  2        2     2           2           2|             
      Inflammation, Focal, Granulomatous   |                            2                                             |             
      Mitotic Alteration                   |                                                                          |             
      Necrosis, Focal                      |                   3                                                      |             
      Necrosis                             |                               2                                          |             
      Bile Duct, Hyperplasia               |                            2  2  2     2     2     2  2  2  2     1  2  1|             
      Midzonal, Degeneration, Fatty        |                                                                          |             
      Peripheral, Degeneration, Fatty      |                                     2                                    |             
      Periportal, Infiltration Cellular,   |                                                                          |             
           Mixed Cell                      |                                        4                                 |             
      Subserosa, Angiectasis               |                                     2                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                               +                       +                  |             
      Hemorrhage                           |                                                                          |             
      Fat, Granuloma                       |                               3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Edema                                |                               3                                          |             
      Acinus, Atrophy                      |                               1                          3  2  3         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               3     2        2        3        2         |             
      Edema                                |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 4| 7| 5| 7| 7| 6| 7| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 5| 1| 3| 6| 3| 3| 4| 3| 3| 3| 7| 5| 4|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 9| 5| 8| 5| 5| 5| 5| 5| 5| 3| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperkeratosis                       |                               3     2        3        3        2        2|             
      Ulcer                                |                                              3                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Mucosa, Erosion, Focal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                        +                                 |             
      Polyarteritis                        |                                        4                                 |             
                                            __________________________________________________________________________|             
   Heart                                   |                            +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                            2     1  1  2  2  1  1  2  2  2  2  2  2  2  2|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           |                                  3                    3        3     2   |             
      Hyperplasia, Focal                   |                                           1        1        1  1  2  2   |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                            +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               4                                          |             
      Pars Distalis, Hyperplasia, Focal    |                            1              3        3                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                     1                                    |             
      Follicle, Dilatation                 |                                           2           2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                               M  +  +  M  +  M  +  +  +  +  +  +  M  M  +|             
      Cyst                                 |                                                                          |             
      Ectasia                              |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                                 3                        |             
      Inflammation, Chronic                |                                  3                                       |             
      Inflammation, Suppurative            |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 4| 7| 5| 7| 7| 6| 7| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 5| 1| 3| 6| 3| 3| 4| 3| 3| 3| 7| 5| 4|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 9| 5| 8| 5| 5| 5| 5| 5| 5| 3| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               2                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Endometrium, Atrophy                 |                                  2  2     2     2        2  2  2  3  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  |                   +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                  3     4  2     2  3        2  2         |             
      Infarct                              |                                                                          |             
      Necrosis, Focal                      |                   3                                                      |             
      Pigmentation, Hemosiderin            |                   2        3              2     2  2        2     3      |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|             
      Congestion                           |                                        3                                 |             
      Cyst                                 |                                                                   X      |             
      Depletion Lymphoid                   |                               2                                      2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                            +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                            3                                             |             
      Hyperplasia                          |                                                                         3|             
      Lactation                            |                               X  X  X  X  X  X  X  X     X  X  X  X  X   |             
                                            __________________________________________________________________________|             
   Skin                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Inflammation, Chronic         |                                           1                              |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                  1                 1     1  2     1  1   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                     X           X        X               |             
      Hemorrhage, Focal                    |                                                                          |             
      Hydrocephalus                        |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 7| 6| 4| 7| 5| 7| 7| 6| 7| 7| 7| 5| 6| 6|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 3| 5| 1| 3| 6| 3| 3| 4| 3| 3| 3| 7| 5| 4|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 5| 4| 9| 5| 8| 5| 5| 5| 5| 5| 5| 3| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             2     2     3|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                              2                           |             
      Inflammation, Chronic                |                               1     2                       2            |             
                                            __________________________________________________________________________|             
   Nose                                    |                            +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                               2                                          |             
      Inflammation, Chronic                |                                           2        2     2  2  3     2   |             
      Inflammation, Suppurative            |                            2                                             |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                         3|             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +  +  +     +  +  +  +  +  +  +  +     +  +|             
      Cataract                             |                               3  2  3     3  3  3  3  2  3  2  3     3  2|             
      Inflammation, Chronic                |                                                                          |             
      Phthisis Bulbi                       |                                                                          |             
      Cornea, Hyperplasia, Focal, Squamous |                                                                          |             
      Cornea, Inflammation                 |                                                 3  2     1               |             
      Retina, Atrophy                      |                                  2  3     2     3  2  3  3  2  2     2  3|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                            +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        3                                 |             
      Nephropathy                          |                            3  2  2  2  2  2     4  3  2  3  2  2  1     1|             
      Collecting Tubule, Casts             |                               X                                          |             
      Pelvis, Dilatation                   |                                                 2                        |             
      Pelvis, Epithelium, Hyperplasia      |                               2           2  2  2  2  3  2  2  1  2      |             
      Pelvis, Epithelium, Mineralization   |                                           2        1     1  1  1  2      |             
      Perirenal Tissue, Inflammation,      |                                                                          |             
          Suppurative                      |                                        2                                 |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis                        |                                                                      4   |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                              4                           |             
      Renal Tubule, Mineralization         |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 7| 9| 1| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3|             
                                           | 5| 5| 5| 7| 3| 4| 3| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    100 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                2                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |       X                                               X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Erosion, Focal               |                                  3                                       |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Basophilic Focus                     | X     X                                X                          X     X|             
      Clear Cell Focus                     | X  X                                                                     |             
      Congestion                           |          3                                                               |             
      Degeneration, Fatty                  |                                                 2        2  2           2|             
      Eosinophilic Focus                   |                      X                                                   |             
      Hepatodiaphragmatic Nodule           | X                    X                 X  X           X  X               |             
      Inflammation, Chronic, Focal         | 2  2  2              2  2              2     1  2     2  3     1  2     2|             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Mitotic Alteration                   |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Necrosis                             |                                  3                                       |             
      Bile Duct, Hyperplasia               | 3        1  2  2        2  3  1  2  2     3        2  2     3  2  2      |             
      Midzonal, Degeneration, Fatty        |                   2                                                      |             
      Peripheral, Degeneration, Fatty      |                               2                    3           2         |             
      Periportal, Infiltration Cellular,   |                                                                          |             
           Mixed Cell                      |                                                                          |             
      Subserosa, Angiectasis               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Hemorrhage                           |                   2                                                      |             
      Fat, Granuloma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                  2                                       |             
      Edema                                |                                                                          |             
      Acinus, Atrophy                      |    3              2           3  2     4  3              1  2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             2  2  3              1                 2           3        2|             
      Edema                                |                   3                                2           3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 7| 9| 1| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3|             
                                           | 5| 5| 5| 7| 3| 4| 3| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    100 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperkeratosis                       |                2  3                                2           3         |             
      Ulcer                                |                   3                                3           3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Mucosa, Erosion, Focal               |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                             +            |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2     2     1           1  1     3  2  1        2        1  1     2   |             
      Atrium, Thrombosis                   |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           |             4                                      3        2            |             
      Hyperplasia, Focal                   |       1        2                       2                          2  2   |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                   2                       2                          2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytomegaly                           |    3                                                                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                   2                                1                    2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3                 4     4        2                    3               |             
      Pars Distalis, Hyperplasia, Focal    | 3                          3        3                                   3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |    2                 1           1           2                           |             
      Follicle, Dilatation                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |             +                                               +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  M  M  M  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Ectasia                              |                                     2                                   2|             
      Fibrosis                             |                                  2                                       |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                           3                              |             
      Inflammation, Suppurative            |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 7| 9| 1| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3|             
                                           | 5| 5| 5| 7| 3| 4| 3| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    100 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                 X                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Endometrium, Atrophy                 |    3  2  2  2        2           1     2        2  2                 2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                   3                                                      |             
      Hematopoietic Cell Proliferation     | 2     2  2           2        2        2     1  2     1  1     3     2  3|             
      Infarct                              |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation, Hemosiderin            | 3  2  2        2  3  2  3              2     2        2              1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |    2     3  3     4              4                    3                  |             
      Lactation                            | X     X  X  X  X  X  X     X  X     X  X  X  X  X  X  X  X     X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                1     1     1                    1  1     1  1            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                      X                                                   |             
      Hemorrhage, Focal                    |                                                                2         |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 4| 7| 7| 4| 5| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 7| 9| 1| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 5| 3| 3| 5| 3| 3| 3| 3|             
                                           | 5| 5| 5| 7| 3| 4| 3| 4| 4| 5| 4| 5| 5| 5| 5| 5| 5| 0| 5| 5| 5| 5| 5| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
    100 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |          3     2  2     3                    2  2     2  2              2|             
      Hemorrhage                           |                                  3                                       |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic                |                                  2                 3        2            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                | 2                                         2  2  2     2  2           2   |             
      Inflammation, Suppurative            |                                                                         2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                       2     3            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             | 2  3  2  3  3  3  2  3        3  3  2  3  3  3  3  3  3  3  3  2  2  2  3|             
      Inflammation, Chronic                |                3                                                         |             
      Phthisis Bulbi                       |                4                                                         |             
      Cornea, Hyperplasia, Focal, Squamous |                                                                          |             
      Cornea, Inflammation                 |                                                             3            |             
      Retina, Atrophy                      | 2  3  2  3  3  2  2  3           2  2  2  2  2  3  2  2  2  2  2  3  2  3|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                         +|             
      Abscess                              |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 1  3  2  3  2  2  3  3  1  2  2  2  2  2  2  2  3  1  3  2  1  3  3  3  4|             
      Collecting Tubule, Casts             |                                                                          |             
      Pelvis, Dilatation                   |                         2                                                |             
      Pelvis, Epithelium, Hyperplasia      | 2        2  4     2  2        2     1     1                          1   |             
      Pelvis, Epithelium, Mineralization   | 2  1  1  2  1                 1     1                 1              1   |             
      Perirenal Tissue, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis                        |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Pigmentation                    |                                                                          |             
      Renal Tubule, Mineralization         |                         2                 2                              |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Lumen, Hemorrhage                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 5| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0|                                            |            |
                                           | 3| 1| 5| 5| 4| 5| 5| 5| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperkeratosis                       |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  A  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  A                                             |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  A  +  +  +  +  +  +  +  A                                             |  47        |
      Edema                                | 3                                                                        |      2  3.0|
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  A  +  +  +  +  +  +  +  A                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  A  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A                                             |  49        |
      Mucosa, Erosion, Focal               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  A                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A                                             |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Angiectasis                          |             3                                                            |      4  2.5|
      Basophilic Focus                     |       X        X     X                                                   |     11     |
      Clear Cell Focus                     |                                                                          |      3     |
      Congestion                           |                                                                          |      1  3.0|
      Degeneration, Fatty                  |                                                                          |      5  2.2|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                X                                                         |     10     |
      Inflammation, Chronic, Focal         |    1  2     3  2     1  2                                                |     24  1.9|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  2.0|
      Mitotic Alteration                   |             4                                                            |      1  4.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Necrosis                             | 2                                                                        |      3  2.3|
      Bile Duct, Hyperplasia               |                         2                                                |     28  2.0|
      Midzonal, Degeneration, Fatty        |                                                                          |      1  2.0|
      Peripheral, Degeneration, Fatty      | 3                                                                        |      5  2.4|
      Periportal, Infiltration Cellular,   |                                                                          |            |
           Mixed Cell                      |                                                                          |      1  4.0|
      Subserosa, Angiectasis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Fat, Granuloma                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Edema                                |                                                                          |      1  3.0|
      Acinus, Atrophy                      |             2  2        3  2                                             |     16  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 5| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0|                                            |            |
                                           | 3| 1| 5| 5| 4| 5| 5| 5| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Acanthosis                           | 2                                                                        |     13  2.2|
      Edema                                |                                                                          |      4  2.8|
      Hyperkeratosis                       | 2                                                                        |     11  2.5|
      Ulcer                                |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Ulcer                                | 3                                                                        |      1  3.0|
      Mucosa, Erosion, Focal               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Polyarteritis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Cardiomyopathy                       |       1        1  2  2  1  1                                             |     34  1.6|
      Atrium, Thrombosis                   | X                                                                        |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Degeneration, Fatty, Focal           |                      2                                                   |      8  2.8|
      Hyperplasia, Focal                   |                      2                                                   |     12  1.6|
      Thrombosis                           | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Focal                   |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cytomegaly                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hypertrophy                          |       2                                                                  |      4  1.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      6  3.3|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      7  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Ultimobranchial Cyst                 |             X                                                            |      1     |
      C-Cell, Hyperplasia                  |                      1                                                   |      6  1.3|
      Follicle, Dilatation                 |                2                                                         |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 5| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0|                                            |            |
                                           | 3| 1| 5| 5| 4| 5| 5| 5| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  M  +  +  +  +  +                                             |  39        |
      Cyst                                 | X                                                                        |      1     |
      Ectasia                              |                                                                          |      2  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Dilatation                           |                2        2                                                |      2  2.0|
      Endometrium, Atrophy                 | 2  2  2              2                                                   |     24  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  M  +  +  +  +  +  +                                             |  49        |
      Hypoplasia                           |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  52        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     | 3  2        4  2     2  2                                                |     26  2.2|
      Infarct                              |                            3                                             |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |    3     2     2                                                         |     21  2.2|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  M  +                                             |  43        |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Depletion Lymphoid                   |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +                                             |  49        |
      Hyperplasia, Cystic                  |                                                                          |      1  3.0|
      Hyperplasia                          |    3                 2                                                   |      9  3.0|
      Lactation                            | X  X  X  X     X  X     X  X                                             |     42     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 5| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0|                                            |            |
                                           | 3| 1| 5| 5| 4| 5| 5| 5| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Other, Inflammation, Chronic         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Acanthosis                           |    1     1     1        2  1                                             |     18  1.1|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  M  +  +  +  +  +  +                                             |  49        |
      Osteopetrosis                        |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Compression                          |          X                                                               |      5     |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Congestion                           |    3     3        2                                                      |     15  2.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |       1                                                                  |      7  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic                |       2        2  2  2  2                                                |     18  2.1|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |             1                                                            |      4  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +     +     +  +  +  +  +  +                                             |  44        |
      Cataract                             | 3     3     3  2  3  3  3  3                                             |     44  2.7|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Phthisis Bulbi                       |                                                                          |      1  4.0|
      Cornea, Hyperplasia, Focal, Squamous |                      3                                                   |      1  3.0|
      Cornea, Inflammation                 |                                                                          |      4  2.3|
      Retina, Atrophy                      |       2     3     3  3  3                                                |     38  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 5| 7| 7| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 5| 7| 3| 3| 3| 3| 0|                                            |            |
                                           | 3| 1| 5| 5| 4| 5| 5| 5| 5| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT LF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Abscess                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Nephropathy                          |    1  3  2     2  2  2  2                                                |     46  2.2|
      Collecting Tubule, Casts             |                                                                          |      1     |
      Pelvis, Dilatation                   |             2                                                            |      3  2.0|
      Pelvis, Epithelium, Hyperplasia      |    2     2  2              2                                             |     23  2.0|
      Pelvis, Epithelium, Mineralization   |    2                                                                     |     16  1.3|
      Perirenal Tissue, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  2.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis                        |                                                                          |      1  4.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Pigmentation                    | 3                                                                        |      2  3.5|
      Renal Tubule, Mineralization         |                                                                          |      2  2.0|
      Renal Tubule, Necrosis               | 4                                                                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +                                             |  47        |
      Lumen, Hemorrhage                    |             3                                                            |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                    3                     |             
      Parasite Metazoan                    |                               X              X                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                    4                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  A  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Basophilic Focus                     |                               X                                          |             
      Clear Cell Focus                     |                                  X                                       |             
      Degeneration, Fatty                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hepatodiaphragmatic Nodule           |                                                    X                     |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                          2               |             
      Inflammation, Chronic, Focal         |                               2  2  2  1  1  3  3     2        1     1   |             
      Inflammation, Focal, Granulomatous   |    2              1                                                      |             
      Mixed Cell Focus                     |                                                       X                  |             
      Necrosis                             |                                                                          |             
      Pigmentation, Focal                  |                                                          2               |             
      Bile Duct, Hyperplasia               |       2  2  2  1  2  2     1  2        1     3     2  1  2  2  1  2      |             
      Hepatocyte, Hyperplasia              |                                                    4                     |             
      Peripheral, Degeneration, Fatty      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                                2         |             
      Fibrosis, Focal                      |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Acinus, Atrophy                      |                      2  2                          1     2              2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                 2  2                 3   |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Edema                                |                                                                      3   |             
      Hemorrhage                           |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperkeratosis                       |                                                                      2   |             
      Ulcer                                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Mucosa, Erosion, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                         4|             
      Cardiomyopathy                       |    1  1  2  1  2     1  1     1     1           2     1  1     2  2  1  2|             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Mineralization, Focal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           |                                     1              2                     |             
      Hyperplasia, Focal                   |                               2  1                                1      |             
      Hypertrophy, Focal                   |                                                          2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                               1                 2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                                   4      |             
      Pars Distalis, Hyperplasia, Focal    |    1                          3                    3                    2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
      Follicle, Dilatation                 |                                                                   1      |             
      Follicular Cell, Hyperplasia         |                                                          2        1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                         +|             
      Abscess                              |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +  +  M  M  M|             
      Ectasia                              |                                                                4         |             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     3        2                           |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Inflammation                         |                                                                         2|             
      Endometrium, Atrophy                 |                                     3     2  3           3           3  2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Exudate                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hypoplasia                           |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                  2  4           1     2  3     2        4|             
      Pigmentation, Hemosiderin            | 2  2  2  2  2  2  2  2  2  2     1        2  2  2     2              3   |             
      Capsule, Hyperplasia                 |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  I  +|             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       1  2  2  3  3                                                      |             
      Hyperplasia                          |                                        3           3                     |             
      Lactation                            |                               X  X  X     X  X  X     X  X     X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Acanthosis                    |                                                                      1   |             
      Other, Hyperkeratosis                |                                                                      1   |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               1  1     1  1  2  1     1  1        1      |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |                                                                      3   |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                    +                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                           2                              |             
      Congestion                           |                               3     2  2  2  2           1              2|             
      Infiltration Cellular, Histiocyte    |                                                       1                  |             
      Inflammation, Chronic                |                                     2  2           3                     |             
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |          2                                                               |             
      Foreign Body                         |                   3     2                                                |             
      Fungus                               |                                                                          |             
      Inflammation, Chronic                |                                  2           2                 2         |             
      Inflammation, Suppurative            |                                                    1                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +  +  +  +  +     +  +  +        +  +  +   |             
      Cataract                             |                               3  3  3  3  3     3  3  3        3  2  3   |             
      Hemorrhage                           |                                                                          |             
      Cornea, Inflammation                 |                                                                          |             
      Retina, Atrophy                      |                               3  3  2  3  3     3     3        3  2  3   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 1  1  2        1  1  1  1  2  2  2  2  2  2  2  3  2  2     1  2  2  1   |             
      Cortex, Mineralization, Focal        |          2                 2                                             |             
      Medulla, Necrosis                    |                                                                          |             
      Pelvis, Epithelium, Hyperplasia      |       1  1     1  2  1        2     1  2     1     2                 2   |             
      Pelvis, Epithelium, Mineralization,  |                                                                          |             
           Focal                           |             1  1  2  1                                                   |             
      Pelvis, Epithelium, Mineralization   |                                        2                                 |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis                        |                                                          4               |             
      Renal Tubule, Mineralization         |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 7| 5| 5| 5| 5| 7| 6| 7| 5| 3| 7| 6| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 3| 6| 9| 9| 8| 3| 8| 3| 8| 6| 3| 5| 4| 2|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 9| 5| 1| 4| 4| 9| 4| 5| 7| 4| 7| 3| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|             
                                           | 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    300 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                         3                                                |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     | X                 X                       X           X                  |             
      Clear Cell Focus                     |          X                          X                                    |             
      Degeneration, Fatty                  |                               2                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X                 X                                    |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Histiocyte                       |                                                                          |             
      Inflammation, Chronic, Focal         | 2  2     1  2              3  2  1  2              2  2  2        2  2   |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Mixed Cell Focus                     |          X                                                               |             
      Necrosis                             |                                                             1            |             
      Pigmentation, Focal                  |                                                                          |             
      Bile Duct, Hyperplasia               | 2     2     2  2     3  2     2  2  2     2              2  2            |             
      Hepatocyte, Hyperplasia              |                                                                          |             
      Peripheral, Degeneration, Fatty      |       2                 2                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Polyarteritis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                   2                                                      |             
      Fibrosis, Focal                      |                                                                          |             
      Inflammation, Focal                  |                                                                          |             
      Acinus, Atrophy                      | 1     1        1              1  3  3                                   2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       3              2  2                       2  3           3        2|             
      Cyst Epithelial Inclusion            |    X                                                                     |             
      Edema                                |       2                 2                          2           4         |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|             
                                           | 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    300 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperkeratosis                       |       3              2  2                       2  3                    2|             
      Ulcer                                |                         4                                      4         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
      Mucosa, Erosion, Focal               |                      3  3                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |                +                                                         |             
      Inflammation, Suppurative            |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cardiomyopathy                       | 1  3     2  2  2  1  2     2  1  2  2     2  2  2  1  3  2           2  2|             
      Atrium, Thrombosis                   |       X                 X                                                |             
      Myocardium, Mineralization, Focal    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           |       2  2                       1  1        2                 2         |             
      Hyperplasia, Focal                   |                                     2  1     2                          1|             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hypertrophy                          |                                              3                          2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                       2            |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                     2                       2            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          3  3              2        2                             2     2|             
      Follicle, Dilatation                 |    2                                3                                2   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Ectasia                              |                                                                3         |             
      Fibrosis                             |                         2                                                |             
      Inflammation, Suppurative            |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|             
                                           | 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    300 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |       X           X        X                       X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                     2                                    |             
      Inflammation                         |                                                                          |             
      Endometrium, Atrophy                 | 2     2     2  2  2                       2                              |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +                                                                  |             
      Exudate                              |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             3                                      4                     |             
      Hematopoietic Cell Proliferation     |    1     2                 3  2  2  2                 2  2        2  2  3|             
      Pigmentation, Hemosiderin            | 3                 2                          3        2  2           2   |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |             3           3                    4        2  3        2  3   |             
      Lactation                            | X  X  X  X  X  X     X     X  X     X  X  X  X  X  X     X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Other, Acanthosis                    |                                                                          |             
      Other, Hyperkeratosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 1           1  1     1                             1     1           1   |             
      Inflammation, Chronic                |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                              X                           |             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|             
                                           | 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    300 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | X              X                          X     X                    X  X|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                                                          |             
      Congestion                           |                2  2        2     3                       3               |             
      Infiltration Cellular, Histiocyte    |                                                                      2   |             
      Inflammation, Chronic                |                                     2                                    |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
      Foreign Body                         |                                              2              2            |             
      Fungus                               |                                              X                           |             
      Inflammation, Chronic                |    2     2  2              2     2     2  2        2              2  2   |             
      Inflammation, Suppurative            |                                              3                           |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                              3                 3         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +     +  +  I  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Cataract                             | 3  3  3  3  3     3  2     2  3  2  3  3  3  3  3  3  3  3     3  3  3  3|             
      Hemorrhage                           |                                                    3                     |             
      Cornea, Inflammation                 |                                              2     3     2               |             
      Retina, Atrophy                      | 2  3  2     2     2  2     2  2     3  2  3  2        2  2     2  2  3  3|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                +         |             
      Cyst                                 |                                                                X         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                      1   |             
      Nephropathy                          | 2  2  1  2  3  2  2  2  2  3  2  2  3  2  2  4  2  4  2  2  1  1  2  3  4|             
      Cortex, Mineralization, Focal        |                                                                          |             
      Medulla, Necrosis                    |       2                                                                  |             
      Pelvis, Epithelium, Hyperplasia      |       1           2     2     2        1  2     1  2     1     2        2|             
      Pelvis, Epithelium, Mineralization,  |                                                                          |             
           Focal                           |                                                                          |             
      Pelvis, Epithelium, Mineralization   |       1           2     1     2        1  2  1  1              2     1  1|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Necrosis                        |                   3                                                      |             
      Renal Tubule, Mineralization         |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 4| 3| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 5| 3| 0| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 8| 4| 3| 3| 8|             
                                           | 8| 5| 9| 5| 5| 9| 8| 5| 6| 5| 5| 4| 4| 4| 4| 5| 4| 4| 4| 4| 9| 4| 4| 4| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    300 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 4| 6| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2|                                            |            |
                                           | 8| 7| 4| 1| 0| 1| 5| 9| 5| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Edema                                |                                                                          |      2  3.0|
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     | X                                                                        |      6     |
      Clear Cell Focus                     |                                                                          |      3     |
      Degeneration, Fatty                  |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         | 2     2     1           2                                                |     27  1.9|
      Inflammation, Focal, Granulomatous   |                                                                          |      2  1.5|
      Mixed Cell Focus                     |                                                                          |      2     |
      Necrosis                             |                            2                                             |      2  1.5|
      Pigmentation, Focal                  |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  1        2  2  2     2  3                                             |     35  1.9|
      Hepatocyte, Hyperplasia              |                                                                          |      1  4.0|
      Peripheral, Degeneration, Fatty      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   1        |
      Polyarteritis                        |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cytoplasmic Alteration, Focal        |                                                                          |      2  2.0|
      Fibrosis, Focal                      |                   3                                                      |      1  3.0|
      Inflammation, Focal                  |                   3                                                      |      1  3.0|
      Acinus, Atrophy                      |          2        1     3  2                                             |     16  1.8|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 4| 6| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2|                                            |            |
                                           | 8| 7| 4| 1| 0| 1| 5| 9| 5| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |    4                                                                     |     11  2.5|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Edema                                |    2                                                                     |      6  2.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |    2                                                                     |      8  2.3|
      Ulcer                                |    4                                                                     |      4  3.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ulcer                                |    3                       3                                             |      2  3.0|
      Mucosa, Erosion, Focal               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  4.0|
      Cardiomyopathy                       |                2  1     1                                                |     38  1.6|
      Atrium, Thrombosis                   |                            X                                             |      3     |
      Myocardium, Mineralization, Focal    |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Fatty, Focal           |                2                                                         |      9  1.7|
      Hyperplasia, Focal                   |       2                                                                  |      8  1.5|
      Hypertrophy, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Focal                   | 3                          3                                             |      5  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hypertrophy                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +                                             |  58        |
      Angiectasis                          |    4                                                                     |      3  2.7|
      Hemorrhage                           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    |    3     2     3                                                         |      9  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |                                                                          |      6  2.3|
      Follicle, Dilatation                 |                                                                          |      4  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 4| 6| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2|                                            |            |
                                           | 8| 7| 4| 1| 0| 1| 5| 9| 5| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              | +                                                                        |   2        |
      Abscess                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +                                             |  50        |
      Ectasia                              |             3        2  3                                                |      5  3.0|
      Fibrosis                             |    2                       2                                             |      3  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  2.5|
      Cyst                                 |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  2.0|
      Endometrium, Atrophy                 |    2           2        2                                                |     15  2.3|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Exudate                              |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hypoplasia                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      2  3.5|
      Hematopoietic Cell Proliferation     |       2           2  3  2                                                |     22  2.3|
      Pigmentation, Hemosiderin            | 3     3  3  3  2                                                         |     27  2.2|
      Capsule, Hyperplasia                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  +  M  +  +  M                                             |  52        |
      Cyst                                 |                                                                          |      1     |
      Depletion Lymphoid                   |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  |                                                                          |      5  2.2|
      Hyperplasia                          |                                                                          |      9  2.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 4| 6| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2|                                            |            |
                                           | 8| 7| 4| 1| 0| 1| 5| 9| 5| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lactation                            | X  X  X  X  X  X  X  X  X  X                                             |     43     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Other, Acanthosis                    |                                                                          |      1  1.0|
      Other, Hyperkeratosis                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |    1  1     2  1  1     1  1                                             |     23  1.1|
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |                                                                          |      1     |
      Hyperostosis                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          | X           X                                                            |      9     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atelectasis                          |                                                                          |      1  2.0|
      Congestion                           |          1     3                                                         |     14  2.1|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      4  2.3|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      4  2.3|
      Fungus                               |                                                                          |      1     |
      Inflammation, Chronic                |       2           2     2                                                |     16  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Glands, Dilatation                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +  +        +  +     +  +                                             |  39        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 5| 4| 6| 7| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 8| 8| 3| 4| 3| 1| 3| 4| 3| 2|                                            |            |
                                           | 8| 7| 4| 1| 0| 1| 5| 9| 5| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT HF                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Cataract                             |    3  3        3  3     3  3                                             |     39  2.9|
      Hemorrhage                           |    2                                                                     |      2  2.5|
      Cornea, Inflammation                 |                                                                          |      3  2.3|
      Retina, Atrophy                      |       3           3     2  3                                             |     32  2.5|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            | 2                                                                        |      2  1.5|
      Nephropathy                          | 2  2  2  2  1  1  2     1  3                                             |     55  2.0|
      Cortex, Mineralization, Focal        |                                                                          |      2  2.0|
      Medulla, Necrosis                    |                                                                          |      1  2.0|
      Pelvis, Epithelium, Hyperplasia      | 2        1  2     1                                                      |     26  1.5|
      Pelvis, Epithelium, Mineralization,  |                                                                          |            |
           Focal                           |                                                                          |      4  1.3|
      Pelvis, Epithelium, Mineralization   |                   1                                                      |     13  1.4|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Necrosis                        |                                                                          |      2  3.5|
      Renal Tubule, Mineralization         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | M  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                2         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  A  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                              3                           |             
      Serosa, Necrosis, Focal              |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                              X                       X   |             
      Muscularis, Degeneration, Focal      |                                                                          |             
      Serosa, Necrosis, Focal              |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Erosion, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                    3                     |             
      Mucosa, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Intussusception                      |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                           X                              |             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic, Focal          |                                              3                           |             
      Degeneration, Fatty, Focal           |                         2                                                |             
      Degeneration, Fatty                  |                               2        2        2  1  1              3  2|             
      Eosinophilic Focus                   |                                              X                           |             
      Focal Cellular Change                |          1                                                               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                       X                  |             
      Inflammation, Chronic, Focal         |                                        2                       1         |             
      Inflammation, Focal, Granulomatous   | 2  2     1  2     2  2  2  2                                             |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  2  3  2  3  2  3  2  3  2     2  2  2  3  2  2  2  3  2  2  2     2|             
      Centrilobular, Degeneration, Fatty   |                                                                          |             
      Hepatocyte, Atrophy                  |                                                                          |             
      Hepatocyte, Hyperplasia, Focal       |                                                                      2   |             
      Midzonal, Degeneration, Fatty        |                                              3                           |             
      Peripheral, Degeneration, Fatty      |                                  2                             2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Granuloma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Accessory Spleen                     |                                                    X                     |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Fibrosis                             |                                                                          |             
      Acinus, Atrophy                      |                1  2     1     2        2  3     3  3     2               |             
      Acinus, Hyperplasia, Focal           |                   1                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Necrosis, Focal          |                                                                         3|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               4        3     1        3  3     3  3  4  2|             
      Edema                                |                               3                       2              2   |             
      Hyperkeratosis                       |                               4        3     2        3  2     2  3  4  2|             
      Ulcer                                |                                        4                       2        3|             
      Muscularis, Necrosis                 |                                                                          |             
      Serosa, Necrosis, Focal              |                                     2                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                       3                  |             
      Foreign Body                         |                               1                                          |             
      Mucosa, Degeneration                 |                                              2  3                        |             
      Mucosa, Erosion, Focal               |                                     2                                    |             
      Muscularis, Necrosis, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                     +           +                       +|             
      Degeneration                         |                                     3           3                       3|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cardiomyopathy                       |    2  3  2     2  2  2  2  3  1  2  3     2  2  4  2  2     1  2     2  3|             
      Atrium, Dilatation                   |                                                                      3   |             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Degeneration, Fatty, Focal           |                      2                 2        4  2                    2|             
      Degeneration                         |                                              3        2           2      |             
      Hyperplasia, Focal                   |    2                                                              2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                     2  2     2                    3     3|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +                          +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    3                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy                          |                                     3  1     3  4        2        2  2  4|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                   4                                                      |             
      Pigmentation                         |                                                                          |             
      Pars Distalis, Cyst                  |                X                                                         |             
      Pars Distalis, Hyperplasia, Focal    |          1                 1                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                        2  3                    1         |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                 +                        |             
      Inflammation                         |                                                 4                        |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  |                               3     2  4  2  4  4        3  1  2  4     4|             
      Fibrosis                             |                                        2     4  2        2        2     3|             
                                            __________________________________________________________________________|             
   Penis                                   |                                     +                    +               |             
      Inflammation, Acute                  |                                                          3               |             
      Thrombosis                           |                                     X                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  M  M  +  M  +  +  +  M  M  +  +  M  +  M  +|             
      Abscess                              |                                     4                                    |             
      Ectasia                              |                                                                   3      |             
      Fibrosis                             |                                     2        3  2        2              2|             
      Duct, Inflammation, Suppurative      |       4                                                                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hyperplasia, Focal                   |                   2                                                      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                               3  3  3  4     3     2  3  4           3  3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                               3        3     3                    3     2|             
      Depletion Cellular                   |                                  3                    3  3               |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
      Polyarteritis                        |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                           1                              |             
      Seminiferous Tubule, Atrophy         |                               4  3        3  3  4        3              3|             
      Seminiferous Tubule, Degeneration    |                                        3                          3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                               2                             2  2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              1                           |             
      Mediastinal, Hemorrhage              |                                              3                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +|             
      Hemorrhage                           |                                              3                           |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Depletion Lymphoid                   |                                                                          |             
      Fibrosis                             |                                              3     3                     |             
      Hematopoietic Cell Proliferation     |                                                 2                 2      |             
      Pigmentation, Hemosiderin            | 2  2  2  1  2  2  2  2  2  2  2        2                       2  2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  I  +|             
      Depletion Lymphoid                   |                                        3        3                        |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Abscess                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Lactation                            |                               X  X  X  X     X  X  X  X  X  X  X  X     X|             
      Duct, Ectasia                        |                                                                          |             
      Duct, Pigmentation                   |                   2                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Inflammation, Suppurative |                                                                          |             
      Other, Cyst Epithelial Inclusion     |                                                                          |             
      Other, Inflammation, Suppurative     |                                                                          |             
      Prepuce, Hyperkeratosis              |                                        2                                 |             
      Prepuce, Inflammation                |                                        2                                 |             
      Sebaceous Gland, Site of             |                                                                          |             
          Application-Mass, Hyperplasia    |                                                                          |             
      Site of Application-Mass, Fibrosis,  |                                                                          |             
           Focal                           |                                                                          |             
      Site of Application-Mass,            |                                                                          |             
          Hyperplasia, Squamous            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 1                                                                        |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                          1               |             
      Cyst Epithelial Inclusion            |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Proliferation Connective Tissue      |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                              X  X                 X     X|             
      Hypoplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Degeneration, Focal                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               X                       X     X  X         |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                                                          |             
      Congestion                           |                2                 3        3                    3  2  3   |             
      Hemorrhage                           |                                              3                           |             
      Infiltration Cellular, Histiocyte    |                                                                         3|             
      Inflammation, Chronic                |                                  3  3     2  3  3                    1  3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |             4                                                            |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Lymphocyte                       |                      3                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                              1  2     2              2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |       3                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                   +      |             
      Hyperkeratosis                       |                                                                   1      |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                            2  3  2  3  3  3  3  3  3  3  3  2  3  3  2  3|             
      Hemorrhage                           |                                              2           2               |             
      Synechia                             |                                                                      4   |             
      Anterior Chamber, Hemorrhage         |                      2                                                   |             
      Cornea, Inflammation                 |                                                                          |             
      Retina, Atrophy                      |                      3     3  3  3  3        2  2  3  2     3  3  2      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 6| 6| 6| 7| 7| 5| 5| 7| 4| 5| 7| 5| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 2| 7| 1| 4| 7| 0| 0| 9| 7| 3| 7| 6| 3| 8| 9|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| 8| 9| 4| 3| 9| 2| 7| 1| 4| 8| 8| 4| 3| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 3  2  3  3  2  3  3  2  3  3  3  3  4  4  2  4  4  4  3  3  3  3  4  3  4|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Epithelium, Hyperplasia      |          2                             2     2  2  2     3        2  2  2|             
      Pelvis, Epithelium, Inflammation     |                                                                          |             
      Renal Tubule, Mineralization         |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Necrosis                             |                                                                          |             
      Mucosa, Hyperplasia                  |                                        3                 3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|             
                                           | 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 UL/RAT                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                         2                       3                       3|             
      Necrosis                             |                                                                4         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  A  +  A  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Serosa, Necrosis, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A  +  +  A  +  A  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                                          X               |             
      Muscularis, Degeneration, Focal      |                               2                                          |             
      Serosa, Necrosis, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Erosion, Focal               |                      3  2                                3               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Mucosa, Necrosis                     |                               2                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  A  +  A  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Intussusception                      |                   4                                                      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |    X                             X  X                                    |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Degeneration, Fatty, Focal           |                                                                          |             
      Degeneration, Fatty                  |    1           2  2        1  1        1        2  1                    1|             
      Eosinophilic Focus                   |                      X                                                   |             
      Focal Cellular Change                |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                          X               |             
      Inflammation, Chronic, Focal         |             3                             2        1           1     1   |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Necrosis                             |                                        1                                 |             
      Bile Duct, Hyperplasia               | 2  2  3  2  2  2  2  2        2  2  2  2  2  3  2  1  2  2  2     2     2|             
      Centrilobular, Degeneration, Fatty   |                                              3                           |             
      Hepatocyte, Atrophy                  |                         2                                                |             
      Hepatocyte, Hyperplasia, Focal       |                                                                          |             
      Midzonal, Degeneration, Fatty        |                                                                   2      |             
      Peripheral, Degeneration, Fatty      |       3                                                                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +     +                           |             
      Fat, Granuloma                       |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|             
                                           | 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 UL/RAT                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Accessory Spleen                     |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Fibrosis                             |                                        4                                 |             
      Acinus, Atrophy                      |             2                       1                          3  1      |             
      Acinus, Hyperplasia, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Necrosis, Focal          |                            2                                             |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       2        1  3  3  4              3     2  4        3     4        3|             
      Edema                                |       2                 3              2     2  2        2     2        3|             
      Hyperkeratosis                       |       2        2  3  2  4              3     2  4        3     4        3|             
      Ulcer                                |                   3     3              4     3           2     3        4|             
      Muscularis, Necrosis                 |    3                                                                     |             
      Serosa, Necrosis, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Mucosa, Degeneration                 |    3     3     3           3  2                       2           2      |             
      Mucosa, Erosion, Focal               |                                                                          |             
      Muscularis, Necrosis, Focal          |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +     +           +  +  +        +           +           +      |             
      Degeneration                         |          3     2           2  2  3        2           3           2      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                        2                                 |             
      Cardiomyopathy                       | 2  4  1  3  2  4  3  1  2  3  4  4  2  3  3  2     2     2  2  1  2  2  2|             
      Atrium, Dilatation                   |                                                                          |             
      Atrium, Thrombosis                   |       X                       X        X  X                       X      |             
      Myocardium, Necrosis                 |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Degeneration, Fatty, Focal           |       1        2     2  3     2        3  2  2     1  3  2              1|             
      Degeneration                         |                               2        3        2                        |             
      Hyperplasia, Focal                   |             1              3                                             |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2  2        2  3  2        2     2              3           2  2   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|             
                                           | 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 UL/RAT                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy                          |    4  2  3  1  3  3  3  3  3  3  3        3     1  3  3  3     2  4     2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pigmentation, Hemosiderin            |                                                                          |             
      Pigmentation                         |                                           3                              |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                   3                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2           2                                            2      |             
      Follicular Cell, Hyperplasia         |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +                          +                    +                        |             
      Inflammation, Suppurative            | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  I  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  |       2     2  3     3  3  4     3  2  3  2  1  3  2  2  3  3     4  3  3|             
      Fibrosis                             |          3     3     3           3     2  3  2  2        3        3  2   |             
                                            __________________________________________________________________________|             
   Penis                                   |                      +     +                          +                  |             
      Inflammation, Acute                  |                                                       2                  |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M|             
      Abscess                              |    3                                                                     |             
      Ectasia                              |          2                 2                                             |             
      Fibrosis                             |          2     2  2  2     2  2  2     3  2  2  2        3        2  3   |             
      Duct, Inflammation, Suppurative      |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |       2                                                                  |             
      Inflammation, Suppurative            |    3  3  4  3  4  3  4  3  3        4     4        3  2  3     3  3     3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    3     2                 3  2                       2        3     3   |             
      Depletion Cellular                   |       3        4  4  4  3        3        3     3  3     3        3     2|             
      Hyperplasia                          |                      3                                                   |             
      Inflammation, Suppurative            |                   3  3                                                   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |             2                                                            |             
      Polyarteritis                        |                      3     3  3                                          |             
      Interstitial Cell, Hyperplasia       |    1     1                       1                                       |             
      Seminiferous Tubule, Atrophy         |       2        3  3  3                 1     4  2     2        2  4     2|             
      Seminiferous Tubule, Degeneration    |    4     2                 3  3  2        2              3  3        3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|             
                                           | 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 UL/RAT                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                  2              2                       2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Hemorrhage                           |    3                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              3              4            |             
      Depletion Lymphoid                   |                                        3                                 |             
      Fibrosis                             |                                        3                    2            |             
      Hematopoietic Cell Proliferation     |                            3  3                                   2      |             
      Pigmentation, Hemosiderin            | 4        2              2  2  2     2           3  1     2     2        2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  M  +  +  +  M  +  M  M  +  M  +  +  M  +  M  +  +  M  +  +|             
      Depletion Lymphoid                   |       2                       3                                         3|             
      Hemorrhage                           |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  M  +  +  +|             
      Abscess                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Lactation                            |    X  X  X  X  X  X  X  X  X        X  X        X  X  X  X  X     X     X|             
      Duct, Ectasia                        |                                  3                                       |             
      Duct, Pigmentation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Inflammation, Suppurative |                                                       1                  |             
      Other, Cyst Epithelial Inclusion     |                                  X                                       |             
      Other, Inflammation, Suppurative     |                                                                         3|             
      Prepuce, Hyperkeratosis              |                                                                          |             
      Prepuce, Inflammation                |                                                                          |             
      Sebaceous Gland, Site of             |                                                                          |             
          Application-Mass, Hyperplasia    |                                                             2            |             
      Site of Application-Mass, Fibrosis,  |                                                                          |             
           Focal                           |                                                             2            |             
      Site of Application-Mass,            |                                                                          |             
          Hyperplasia, Squamous            |                                                             2            |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      2                                                   |             
      Cyst Epithelial Inclusion            |       X                                                                 X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|             
                                           | 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 UL/RAT                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Proliferation Connective Tissue      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |    X     X     X  X  X  X  X  X  X        X        X  X  X        X      |             
      Hypoplasia                           |                                                                         2|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
      Degeneration, Focal                  |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |             2           2                                                |             
      Congestion                           | 3              3                 2        2  2  2  2                    2|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic                |    4  1  3     4     3     2  3  2        2           3           2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                      X              X                          X         |             
      Infiltration Cellular, Diffuse,      |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Chronic                |                                        2  3        2        2            |             
      Inflammation, Suppurative            |                      2                             2                 2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                    3                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +     +     +  M  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |    2     3     3     3  2  3  3  4     2  3  3     3  3  3  3  3  3  3  3|             
      Hemorrhage                           |                                                       3                  |             
      Synechia                             |                                                                          |             
      Anterior Chamber, Hemorrhage         |                                                                          |             
      Cornea, Inflammation                 |                            3  2                    2  3                  |             
      Retina, Atrophy                      |    2     2     2     2  2  3  2  3     2  3  3  2  3     2     3  2  2  3|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 6| 5| 5| 5| 6| 6| 6| 5| 7| 6| 6| 3| 6| 6| 6| 6| 5| 6| 6| 7| 5| 6| 5| 6|             
                             DAY ON TEST   | 6| 0| 8| 8| 2| 9| 2| 8| 0| 3| 8| 2| 9| 5| 5| 2| 3| 6| 6| 7| 3| 9| 9| 4| 3|             
                                           | 4| 0| 2| 7| 7| 1| 6| 7| 2| 0| 0| 9| 9| 2| 1| 9| 6| 8| 8| 4| 4| 8| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
    0 UL/RAT                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                        3                                 |             
      Nephropathy                          | 1  4  2  4  2  4  4  4  4  4  4  4  2  3  4  2  4  4  4  4  3  4  4  3  3|             
      Pelvis, Dilatation                   |                   2                                                      |             
      Pelvis, Epithelium, Hyperplasia      |    4     2        3  3  2     2        2  2     2  2  2  3  2     2      |             
      Pelvis, Epithelium, Inflammation     |                                                          2               |             
      Renal Tubule, Mineralization         | 3                                                                        |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 4                                                                        |             
      Inflammation, Chronic                |                2                                                         |             
      Inflammation, Suppurative            | 3                                                                        |             
      Necrosis                             | 3                                                                        |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 7| 6| 5| 5| 6| 5| 6|                                            |            |
                             DAY ON TEST   | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8|                                            |            |
                                           | 0| 8| 2| 5| 6| 4| 4| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      4  2.5|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +                                             |  50        |
      Congestion                           |                4                                                         |      1  4.0|
      Edema                                |                                                                          |      1  3.0|
      Serosa, Necrosis, Focal              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +                                             |  51        |
      Edema                                |                4                                                         |      1  4.0|
      Parasite Metazoan                    |                                                                          |      3     |
      Muscularis, Degeneration, Focal      |                                                                          |      1  2.0|
      Serosa, Necrosis, Focal              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +                                             |  57        |
      Mucosa, Erosion, Focal               |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +                                             |  54        |
      Hemorrhage, Focal                    |                                                                          |      1  3.0|
      Mucosa, Necrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +                                             |  52        |
      Intussusception                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                   X                                                      |      4     |
      Degeneration, Cystic, Focal          |       2                                                                  |      2  2.5|
      Degeneration, Fatty, Focal           |                                                                          |      1  2.0|
      Degeneration, Fatty                  |       2              2     1                                             |     19  1.6|
      Eosinophilic Focus                   |                                                                          |      2     |
      Focal Cellular Change                |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                         2                                                |      1  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Inflammation, Chronic, Focal         |       2  2                                                               |      9  1.7|
      Inflammation, Focal, Granulomatous   |                                                                          |      8  1.9|
      Necrosis                             |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               | 3     2  2  2  3  2  2  2  3                                             |     53  2.2|
      Centrilobular, Degeneration, Fatty   |                                                                          |      1  3.0|
      Hepatocyte, Atrophy                  |                                                                          |      1  2.0|
      Hepatocyte, Hyperplasia, Focal       |                3                                                         |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 7| 6| 5| 5| 6| 5| 6|                                            |            |
                             DAY ON TEST   | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8|                                            |            |
                                           | 0| 8| 2| 5| 6| 4| 4| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Midzonal, Degeneration, Fatty        |                                                                          |      2  2.5|
      Peripheral, Degeneration, Fatty      |    3                                                                     |      4  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   4        |
      Fat, Granuloma                       |                3                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Spleen                     |                                                                          |      1     |
      Cytoplasmic Alteration, Focal        |                         2                                                |      1  2.0|
      Fibrosis                             |                                                                          |      1  4.0|
      Acinus, Atrophy                      |    2     2     2           1                                             |     17  1.9|
      Acinus, Hyperplasia, Focal           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  M  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  M  +  +  +  +  +  +  +  +                                             |  59        |
      Muscularis, Necrosis, Focal          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +                                             |  59        |
      Acanthosis                           | 3     2     1  3     3                                                   |     25  2.8|
      Edema                                | 3                    3                                                   |     13  2.4|
      Hyperkeratosis                       | 3     2     1  3     3                                                   |     25  2.8|
      Ulcer                                | 3              2     2                                                   |     13  2.9|
      Muscularis, Necrosis                 |                            2                                             |      2  2.5|
      Serosa, Necrosis, Focal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  M  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |                                                                          |      1  3.0|
      Foreign Body                         |                                                                          |      1  1.0|
      Mucosa, Degeneration                 |                         3  2                                             |     11  2.5|
      Mucosa, Erosion, Focal               |                                                                          |      1  2.0|
      Muscularis, Necrosis, Focal          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |             +              +                                             |  13        |
      Degeneration                         |             3              2                                             |     13  2.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  2.0|
      Cardiomyopathy                       | 2  2  2  3  3  2  1  2  3  4                                             |     53  2.3|
      Atrium, Dilatation                   |                                                                          |      1  3.0|
      Atrium, Thrombosis                   |    X                                                                     |      6     |
      Myocardium, Necrosis                 |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 7| 6| 5| 5| 6| 5| 6|                                            |            |
                             DAY ON TEST   | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8|                                            |            |
                                           | 0| 8| 2| 5| 6| 4| 4| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      1  2.0|
      Degeneration, Fatty, Focal           |       1  2              2  2                                             |     21  2.0|
      Degeneration                         |    2                                                                     |      7  2.3|
      Hyperplasia, Focal                   | 1                          2                                             |      6  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Focal                   | 2  2        2  3        2  3                                             |     21  2.3|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Focal                   |                1                                                         |      1  1.0|
      Hypertrophy                          |       3     3        3  4  4                                             |     32  2.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  M  +  +  +  +  +  +  +                                             |  54        |
      Pigmentation, Hemosiderin            |                                                                          |      1  4.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                            4                                             |      4  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      C-Cell, Hyperplasia                  |                1                                                         |      7  1.9|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |    +                                                                     |   4        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Degeneration, Focal                  |       3        4     3  3  3                                             |     35  2.9|
      Fibrosis                             |    2           3     3                                                   |     20  2.6|
                                            __________________________________________________________________________|____________|
   Penis                                   |                +                                                         |   6        |
      Inflammation, Acute                  |                1                                                         |      3  2.0|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | M  M  M  +  +  +  M  +  +  +                                             |  44        |
      Abscess                              |                                                                          |      2  3.5|
      Ectasia                              |                         3                                                |      4  2.5|
      Fibrosis                             |                3           2                                             |     21  2.2|
      Duct, Inflammation, Suppurative      |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 7| 6| 5| 5| 6| 5| 6|                                            |            |
                             DAY ON TEST   | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8|                                            |            |
                                           | 0| 8| 2| 5| 6| 4| 4| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            | 2           2                                                            |     29  3.1|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              | 2     2        3                                                         |     15  2.6|
      Depletion Cellular                   |    3                 3                                                   |     17  3.1|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypoplasia                           |                                                                          |      1  2.0|
      Polyarteritis                        |                                                                          |      3  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      4  1.0|
      Seminiferous Tubule, Atrophy         | 2        2  2  2           2                                             |     23  2.7|
      Seminiferous Tubule, Degeneration    |    2  3              3                                                   |     14  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hypoplasia                           |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Mediastinal, Hemorrhage              |                4                                                         |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +                                             |  54        |
      Hemorrhage                           |                4                                                         |      3  3.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      3  3.0|
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      4  2.8|
      Hematopoietic Cell Proliferation     |    3  3                 3                                                |      8  2.6|
      Pigmentation, Hemosiderin            |                      2                                                   |     26  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  +  +  M                                             |  45        |
      Depletion Lymphoid                   |                                                                          |      5  2.8|
      Hemorrhage                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  M  +                                             |  54        |
      Abscess                              |                            4                                             |      1  4.0|
      Hyperplasia                          |       2                                                                  |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 7| 6| 5| 5| 6| 5| 6|                                            |            |
                             DAY ON TEST   | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8|                                            |            |
                                           | 0| 8| 2| 5| 6| 4| 4| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Lactation                            | X  X     X  X  X  X  X     X                                             |     39     |
      Duct, Ectasia                        |                                                                          |      1  3.0|
      Duct, Pigmentation                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Abdominal, Inflammation, Suppurative |                                                                          |      1  1.0|
      Other, Cyst Epithelial Inclusion     |                                                                          |      1     |
      Other, Inflammation, Suppurative     | 2  1                                                                     |      3  2.0|
      Prepuce, Hyperkeratosis              |                                                                          |      1  2.0|
      Prepuce, Inflammation                |                                                                          |      1  2.0|
      Sebaceous Gland, Site of             |                                                                          |            |
          Application-Mass, Hyperplasia    |                                                                          |      1  2.0|
      Site of Application-Mass, Fibrosis,  |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Site of Application-Mass,            |                                                                          |            |
          Hyperplasia, Squamous            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      2  1.5|
      Cyst Epithelial Inclusion            |                                                                          |      3     |
      Proliferation Connective Tissue      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fibrous Osteodystrophy               |       X     X           X  X                                             |     22     |
      Hypoplasia                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Degeneration, Focal                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                   X                                                      |      5     |
      Hemorrhage                           |                   2                                                      |      1  2.0|
      Inflammation, Chronic, Focal         |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atelectasis                          |                                                                          |      2  2.0|
      Congestion                           |          2  3     3     2                                                |     18  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 5| 5| 7| 6| 5| 5| 6| 5| 6|                                            |            |
                             DAY ON TEST   | 2| 4| 0| 3| 4| 9| 2| 7| 9| 8|                                            |            |
                                           | 0| 8| 2| 5| 6| 4| 4| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      A     |
    0 UL/RAT                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
     UM                                    | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  3.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Inflammation, Chronic                |             4        2  2  3                                             |     22  2.6|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         | 2           3           2                                                |      3  2.3|
      Fungus                               |                                                                          |      4  4.0|
      Infiltration Cellular, Diffuse,      |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      4  2.3|
      Inflammation, Suppurative            |                                                                          |      7  1.9|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Hyperkeratosis                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Eye                                     | +     +  +  +  +     +  +  +                                             |  45        |
      Cataract                             | 3     3  2  3  2     3  3  3                                             |     44  2.8|
      Hemorrhage                           |                         3                                                |      4  2.5|
      Synechia                             |                                                                          |      1  4.0|
      Anterior Chamber, Hemorrhage         |                                                                          |      1  2.0|
      Cornea, Inflammation                 |                            3                                             |      5  2.6|
      Retina, Atrophy                      | 3     3  2  3  1     2                                                   |     36  2.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Nephropathy                          | 4  2  4  2  4  3  3  4  4  4                                             |     60  3.3|
      Pelvis, Dilatation                   |                                                                          |      1  2.0|
      Pelvis, Epithelium, Hyperplasia      | 2  2  2  2  2        2     2                                             |     30  2.2|
      Pelvis, Epithelium, Inflammation     |                                                                          |      1  2.0|
      Renal Tubule, Mineralization         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                         +                                                |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
      Muscularis, Necrosis, Focal          |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Erosion, Focal               |                                                    3                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                               +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Degeneration, Cystic, Focal          |                                                       3                  |             
      Degeneration, Fatty                  |                                                          2               |             
      Eosinophilic Focus                   |                               X                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic, Focal         |                                        2  2                          1   |             
      Necrosis                             |                                                    2                     |             
      Bile Duct, Hyperplasia               |                               2  2  2  1  2  2  2  4  3  2     2  2  2  2|             
      Centrilobular, Degeneration, Fatty   |                                                    3                     |             
      Peripheral, Degeneration, Fatty      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Granuloma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                                2         |             
      Acinus, Atrophy                      |                                  3  3     2        3              2      |             
      Interlobular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Necrosis, Focal          |                                                 2                        |             
      Serosa, Inflammation, Necrotizing    |                                  3                                       |             
      Serosa, Necrosis, Focal              |                                              2                           |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                       3  2     2     3  3|             
      Edema                                |                                                          2               |             
      Hyperkeratosis                       |                                                       2        2     3  2|             
      Ulcer                                |                                                       2              2   |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
      Serosa, Inflammation, Proliferative  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                2         |             
      Epithelium, Degeneration             |                                              3                           |             
      Epithelium, Hyperplasia              |                                              3                           |             
      Mucosa, Degeneration                 |                                  2              3                        |             
      Mucosa, Erosion, Focal               |                                                    3                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                  +           +  +              +         |             
      Degeneration                         |                                  3           3  2              3         |             
                                            __________________________________________________________________________|             
   Heart                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                               3  3  2        4  4  2  2  2  2  2  1  2  3|             
      Atrium, Thrombosis                   |                                                    X     X               |             
      Myocardium, Necrosis, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Fatty, Focal           |                                  3                                2  3   |             
      Degeneration                         |                                                       3           2      |             
      Hyperplasia, Focal                   |                                     2           2     2                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                               2  1                             2     2  2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                               3  3           3  3     3  2     3     3  3|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                               X                                          |             
      Pars Distalis, Hyperplasia, Focal    |                               3                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                              2                          2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                        +                    +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  |                               3  3  1        4  2  4  4  4  4  3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                               2                       2  2     3  2  2   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                               M  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Abscess, Acute                       |                                                                          |             
      Abscess                              |                                                             3            |             
      Ectasia                              |                                                    2                     |             
      Fibrosis                             |                                  2                 2     2  3  2        2|             
      Inflammation, Chronic                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Prostate                                |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                                           4  3        4        3         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3  2           3     2        2           2|             
      Depletion Cellular                   |                                                       4  2     4  3  3   |             
      Inflammation, Suppurative            |                                                                4         |             
                                            __________________________________________________________________________|             
   Testes                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
      Polyarteritis                        |                                                       2                 3|             
      Interstitial Cell, Hyperplasia       |                                                          1               |             
      Seminiferous Tubule, Atrophy         |                               4  2  3           3  1  3  2  3  3  2  3  3|             
      Seminiferous Tubule, Degeneration    |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |                                                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                          3               |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                  3              2        2              2|             
      Infarct                              |                                                                          |             
      Pigmentation, Hemosiderin            |                                     2  3  3                             2|             
      Capsule, Hyperplasia, Focal          |                                                                          |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                               +  +  +  M  +  +  +  +  +  +  +  I  I  +  +|             
      Depletion Lymphoid                   |                                  2                       2           2   |             
      Hyperplasia, Pseudoepitheliomatous   |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                               +  M  +  +  +  +  +  +  +  M  +  M  +  M  M|             
      Galactocele                          |                                                       X                  |             
      Hyperplasia                          |                                                                          |             
      Lactation                            |                               X     X  X  X  X  X  X  X     X     X      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +     +     +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Edema                     |                                                          2               |             
      Abdominal, Exudate                   |                                  X                                       |             
      Foot, Hemorrhage                     |                                        4                                 |             
      Other, Inflammation, Acute           |                1                                                         |             
                                            __________________________________________________________________________|             
   Skin, Control                           |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +     +        +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 1  1     1        1  1                                                   |             
      Exudate                              |                                                                         2|             
      Inflammation, Suppurative            |                                                                         2|             
      Proliferation Connective Tissue      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                               X  X           X  X     X        X     X  X|             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                 +                        |             
      Diaphragm, Necrosis, Focal           |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                     X     X                       X  X   |             
      Hydrocephalus                        |                                           3                              |             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                                                          |             
      Congestion                           |                                  2  3                                    |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                      1   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                  2           2  2                        |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                 X                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 6| 6| 3| 3| 6| 7| 6| 7| 6| 7| 6| 6| 6| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 8| 6| 2| 0| 5| 0| 0| 6| 3| 7| 3| 5| 2| 1| 3|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 0| 6| 0| 4| 9| 1| 1| 5| 4| 3| 5| 4| 0| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fibrosis, Focal                      |                                                                          |             
      Foreign Body                         |                                  4           2     2                     |             
      Fungus                               |                                                    X                     |             
      Inflammation, Chronic                |                                                       2                  |             
      Inflammation, Suppurative            |                                  4                                       |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +  +  +        +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                               3  3  3        3  3  3  3  3  3  2  3  3  2|             
      Hemorrhage                           |                                  3              3                        |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Cornea, Inflammation                 |                                                                          |             
      Retina, Atrophy                      |                               3  3  3        3  2  2  3  3  3  2  3  3  3|             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |                               4  4  3  2  2  4  4  2  4  3  3  4  3  4  4|             
      Pelvis, Dilatation                   |                                                                          |             
      Pelvis, Epithelium, Hyperplasia      |                               2        1        2        2     3         |             
      Pelvis, Epithelium, Mineralization   |                                           2                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|             
                                           | 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                2  2     2|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
      Muscularis, Necrosis, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Erosion, Focal               |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Degeneration, Fatty                  |    1                          2                                      3   |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Inflammation, Chronic, Focal         |                                              1  3        2  1            |             
      Necrosis                             |          2              3                                                |             
      Bile Duct, Hyperplasia               | 2     2  2  1  3  1  2  2     2  2  2  3  3  1     2  2        2  2      |             
      Centrilobular, Degeneration, Fatty   |                                        3                                 |             
      Peripheral, Degeneration, Fatty      |                      4                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +     +                                                        +   |             
      Fat, Granuloma                       |             3                                                        2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Acinus, Atrophy                      | 1           2     3     2              2        2  2        2        2   |             
      Interlobular, Inflammation, Chronic  |       3                                                                  |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                         +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Necrosis, Focal          |                                                    2           2         |             
      Serosa, Inflammation, Necrotizing    |                                                                          |             
      Serosa, Necrosis, Focal              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           | 3     3     4        4     3        2                    3        4      |             
      Edema                                |       3     4                                                     3      |             
      Hyperkeratosis                       | 3     3     4        3     3        2                    3        4      |             
      Ulcer                                |       4     4        2     4                                      4      |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
      Serosa, Inflammation, Proliferative  |             4                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|             
                                           | 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Epithelium, Degeneration             |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
      Mucosa, Degeneration                 |                                           2                    3         |             
      Mucosa, Erosion, Focal               |                                                          3               |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Inflammation, Suppurative            |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                   +              +                 +           +         |             
      Degeneration                         |                   2                                2           3         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  1  2  2  1  2  3     2  1  2  1  2  1  3        4     3  2  3  2  2  2|             
      Atrium, Thrombosis                   |          X              X              X                                 |             
      Myocardium, Necrosis, Focal          |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            3                                             |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Fatty, Focal           | 2  1  3  2  2        2  3  1        2     2  2        2  2     2         |             
      Degeneration                         |                                                                          |             
      Hyperplasia, Focal                   |    2                                                  3     2        2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   | 2     3  2  2     2     2  2     2  3  2                 2     2  1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          | 3     3  2  3     3     2           2     3        3     3  2  4  3      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                1                          3                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2                                               2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |          +                                                               |             
      Inflammation, Suppurative            |          4                                                               |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  | 3     3  2     1  3  3  4  3     2     2  4           2  4  2     3  3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|             
                                           | 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |          3        2     3           3                    2     2  2  2   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                    +                 +   |             
      Inflammation, Acute                  |                                                    4                 3   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +|             
      Abscess, Acute                       |                                                                         2|             
      Abscess                              |                                                                          |             
      Ectasia                              |                                                                          |             
      Fibrosis                             |       2  2  1        2  3        2  2  2           2     3  2  3        2|             
      Inflammation, Chronic                |                      3           2                                       |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    3                                                                     |             
      Inflammation, Suppurative            | 3     4  4  3     3     4  3  3  2  4  3     2  3     2  4        3     4|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 3           3              3           3           2              3      |             
      Depletion Cellular                   |    4  3  4        3  4  3           4                    4     3         |             
      Inflammation, Suppurative            |                   3                 2                                    |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
      Polyarteritis                        |                                                          3     3         |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
      Seminiferous Tubule, Atrophy         | 3     2  3  2     2  3  2  3        3     2  2     4                 3   |             
      Seminiferous Tubule, Degeneration    |                      2                                   3  2  4  3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |    2        2        2                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                                                |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    3                                   2                                 |             
      Hematopoietic Cell Proliferation     |       3  3                          2                    2               |             
      Infarct                              |                                        3                                 |             
      Pigmentation, Hemosiderin            |    2  2              3     2                       3     2              2|             
      Capsule, Hyperplasia, Focal          |                                                                          |             
      Capsule, Hyperplasia                 |                         3                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  I  +  +  M  +  M  +  +  +  I  +  +  +  +  +  +  +  M  M  +  +|             
      Depletion Lymphoid                   |                   2                                                      |             
      Hyperplasia, Pseudoepitheliomatous   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|             
                                           | 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  M  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  M  +  M|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |                               3                    3                     |             
      Lactation                            | X  X  X  X        X  X     X        X  X  X  X  X  X     X  X  X     X   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Edema                     |                                                                          |             
      Abdominal, Exudate                   |                                                                          |             
      Foot, Hemorrhage                     |                                                                          |             
      Other, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                   X      |             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               1  1                                   2   |             
      Exudate                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Proliferation Connective Tissue      |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               | X                 2                                X     X     X  X      |             
      Hyperostosis                         |                                                       X                  |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Necrosis, Focal           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    X     X                                   X                           |             
      Hydrocephalus                        |                                                                          |             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                                                   3      |             
      Congestion                           |    3  2                    1  3              3           3     3     2   |             
      Hemorrhage                           |                                                                2         |             
      Infiltration Cellular, Histiocyte    |                   2                                            3         |             
      Inflammation, Acute                  |       3                                                                  |             
      Inflammation, Chronic                |    2     4        2     4        3  2           1  3           3        3|             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 6| 5| 7| 6| 4| 7| 5| 5| 5| 6| 5| 7| 5| 5| 7| 4| 7| 7| 7| 5| 5| 5|             
                             DAY ON TEST   | 5| 5| 6| 8| 5| 0| 0| 8| 1| 4| 8| 9| 9| 1| 3| 5| 4| 1| 9| 2| 3| 1| 6| 9| 2|             
                                           | 9| 3| 5| 7| 6| 4| 1| 6| 8| 3| 4| 1| 2| 9| 5| 9| 2| 6| 0| 3| 4| 8| 0| 7| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    100 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Fibrosis, Focal                      |             1                                                            |             
      Foreign Body                         |                                  2                    2                  |             
      Fungus                               |             X                                      X                     |             
      Inflammation, Chronic                |                                     2                       2            |             
      Inflammation, Suppurative            |                                                          2               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                  2                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +                                                         |             
                                            __________________________________________________________________________|             
   Eye                                     | +     +  +  +  +     +  +  +  +  +  +     +  +  +  +     +  +  +  +  +   |             
      Cataract                             | 3     3  3  3  3     2  3  3  2  3  2     3  3  2  3     3  3  3  3  3   |             
      Hemorrhage                           |                                           3                              |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |          3                                                               |             
      Cornea, Inflammation                 |                                     2        3     3           2         |             
      Retina, Atrophy                      | 4        2  2  2        2        3  2     3        2     2  3     3  3   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                           +                              |             
      Abscess                              |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 4  2  4  4  4  3  4  3  2  4  2  2  4  2  4  3  3  4  2  4  3  4  4  3  2|             
      Pelvis, Dilatation                   |                            2                                             |             
      Pelvis, Epithelium, Hyperplasia      | 2     3  3  2  2     2  1           3  1  2        3  2  2     1  2      |             
      Pelvis, Epithelium, Mineralization   |                         1                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6|                                            |            |
                                           | 2| 4| 4| 9| 1| 3| 0| 4| 0| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  M  +  +                                             |  49        |
      Hyperkeratosis                       |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  47        |
      Parasite Metazoan                    |                                                                          |      1     |
      Muscularis, Necrosis, Focal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Mucosa, Erosion, Focal               |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Degeneration, Cystic, Focal          | 2                    2                                                   |      3  2.3|
      Degeneration, Fatty                  |                      2                                                   |      5  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation, Chronic, Focal         |       2        2  2     2                                                |     11  1.8|
      Necrosis                             |                                                                          |      3  2.3|
      Bile Duct, Hyperplasia               | 3  2  3  2  2  3  2  1  2  2                                             |     42  2.1|
      Centrilobular, Degeneration, Fatty   |                                                                          |      2  3.0|
      Peripheral, Degeneration, Fatty      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
      Fat, Granuloma                       |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Acinus, Atrophy                      |    3           1     3                                                   |     17  2.2|
      Interlobular, Inflammation, Chronic  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Muscularis, Necrosis, Focal          |                                                                          |      3  2.0|
      Serosa, Inflammation, Necrotizing    |                                                                          |      1  3.0|
      Serosa, Necrosis, Focal              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Acanthosis                           | 4  2     3  3  3  4  3  3                                                |     21  3.0|
      Edema                                | 3        4     3  3  2                                                   |      9  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6|                                            |            |
                                           | 2| 4| 4| 9| 1| 3| 0| 4| 0| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperkeratosis                       | 4  2     4  4  3  4  4  3                                                |     20  3.1|
      Ulcer                                | 4        4     4  3  3  3                                                |     13  3.3|
      Serosa, Inflammation, Suppurative    |                   4                                                      |      1  4.0|
      Serosa, Inflammation, Proliferative  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Epithelium, Degeneration             |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
      Mucosa, Degeneration                 |                            3                                             |      5  2.6|
      Mucosa, Erosion, Focal               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   8        |
      Degeneration                         |                                                                          |      7  2.6|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cardiomyopathy                       | 1  2  3  2  2  3  2  2  2  2                                             |     44  2.2|
      Atrium, Thrombosis                   |                                                                          |      5     |
      Myocardium, Necrosis, Focal          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cytoplasmic Alteration, Focal        |    2                                                                     |      1  2.0|
      Degeneration, Fatty, Focal           |       3              2  2  2                                             |     21  2.1|
      Degeneration                         |       3                                                                  |      3  2.7|
      Hyperplasia, Focal                   | 3                       2                                                |      9  2.2|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hyperplasia, Focal                   | 2        2  2  3  1     2  2                                             |     25  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hypertrophy                          |    4  3  2     2  2  2  3  3                                             |     30  2.8|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Angiectasis                          |       4                                                                  |      1  4.0|
      Cyst                                 |                         X                                                |      2     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6|                                            |            |
                                           | 2| 4| 4| 9| 1| 3| 0| 4| 0| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                2  1  1                                                   |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                                                                          |   1        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  48        |
      Degeneration, Focal                  | 3  4     2  4  3  3  3  3  3                                             |     38  3.0|
      Fibrosis                             | 2  3           2  2  2  2                                                |     20  2.3|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
      Inflammation, Acute                  |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  46        |
      Abscess, Acute                       |                                                                          |      1  2.0|
      Abscess                              |                                                                          |      1  3.0|
      Ectasia                              |                                                                          |      1  2.0|
      Fibrosis                             | 2  2        2        3                                                   |     23  2.2|
      Inflammation, Chronic                | 2           3                                                            |      5  2.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Suppurative            |    3              3  2  4                                                |     25  3.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Atrophy                              |             3                                                            |     13  2.6|
      Depletion Cellular                   | 3  3     3        4  3  3  2                                             |     21  3.3|
      Inflammation, Suppurative            |                         3                                                |      4  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Hypoplasia                           |                            2                                             |      1  2.0|
      Polyarteritis                        |                                                                          |      4  2.8|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  1.0|
      Seminiferous Tubule, Atrophy         | 2  3     1  4  2  3                                                      |     31  2.6|
      Seminiferous Tubule, Degeneration    |                      3  3                                                |      8  2.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hypoplasia                           |                2  2  2                                                   |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Mediastinal, Angiectasis             |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6|                                            |            |
                                           | 2| 4| 4| 9| 1| 3| 0| 4| 0| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Fibrosis                             |       3                 2                                                |      4  2.5|
      Hematopoietic Cell Proliferation     |                            3                                             |      9  2.4|
      Infarct                              |                                                                          |      1  3.0|
      Pigmentation, Hemosiderin            |             2        2  2                                                |     14  2.3|
      Capsule, Hyperplasia, Focal          |                2                                                         |      1  2.0|
      Capsule, Hyperplasia                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  I  +  +  +  +  +  M                                             |  37        |
      Depletion Lymphoid                   |                                                                          |      4  2.0|
      Hyperplasia, Pseudoepitheliomatous   |                   2                                                      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  38        |
      Galactocele                          |                                                                          |      1     |
      Hyperplasia                          |             3                                                            |      3  3.0|
      Lactation                            | X  X  X  X  X  X  X  X  X  X                                             |     37     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Abdominal, Edema                     |                                                                          |      1  2.0|
      Abdominal, Exudate                   |                                                                          |      1     |
      Foot, Hemorrhage                     |                                                                          |      1  4.0|
      Other, Inflammation, Acute           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Acanthosis                           |    1                 2                                                   |     10  1.2|
      Exudate                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Proliferation Connective Tissue      |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Fibrous Osteodystrophy               |    X        X     X     X  X                                             |     20  2.0|
      Hyperostosis                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6|                                            |            |
                                           | 2| 4| 4| 9| 1| 3| 0| 4| 0| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Diaphragm, Necrosis, Focal           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Compression                          |                X                                                         |      8     |
      Hydrocephalus                        |                                                                          |      1  3.0|
      Infarct                              |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Atelectasis                          |                                                                          |      1  3.0|
      Congestion                           | 2              2     2                                                   |     13  2.4|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |    3                                                                     |     14  2.6|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Exudate                              |                                                                          |      1     |
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Foreign Body                         |                                                                          |      5  2.4|
      Fungus                               |    2                                                                     |      4  2.0|
      Inflammation, Chronic                |       2           2                                                      |      5  2.0|
      Inflammation, Suppurative            |                                                                          |      2  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +                                             |  43        |
      Cataract                             | 3  3  3  3  3  3  2  3  2  3                                             |     43  2.8|
      Hemorrhage                           |                         3                                                |      4  3.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Cornea, Inflammation                 |                                                                          |      4  2.5|
      Retina, Atrophy                      | 3  4     3  2  2  2  2  3  3                                             |     35  2.7|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                +           +                                             |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 6| 7| 6| 6| 6| 6| 6|                                            |            |
                             DAY ON TEST   | 5| 5| 3| 3| 0| 5| 4| 5| 4| 6|                                            |            |
                                           | 2| 4| 4| 9| 1| 3| 0| 4| 0| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      A     |
    100 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT LM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Abscess                              |                4                                                         |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Nephropathy                          | 3  4  3  4  4  3  4  4  4  4                                             |     50  3.3|
      Pelvis, Dilatation                   |    3                                                                     |      2  2.5|
      Pelvis, Epithelium, Hyperplasia      | 2  3  2     3  2  2     2  2                                             |     28  2.1|
      Pelvis, Epithelium, Mineralization   |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Ulcer                                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                  3                                       |             
      Parasite Metazoan                    |                                                 X                        |             
      Ulcer                                |                                  4                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                              X                           |             
      Degeneration, Cystic, Focal          |       2                                2                                 |             
      Degeneration, Fatty, Focal           |                         2                                                |             
      Degeneration, Fatty                  |                                                    1                     |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Chronic, Focal         |                               1              2  2           2     2  2   |             
      Inflammation, Focal, Granulomatous   | 2  2     2  2     1  2  2                                                |             
      Necrosis                             |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2  2  2  3  3  2  2  1     2  3     2  2  2  2  2  2     2  2  2  2  3|             
      Centrilobular, Degeneration, Fatty   |             2                                                            |             
      Midzonal, Degeneration, Fatty        |                                                                          |             
      Peripheral, Degeneration, Fatty      |                                                                          |             
      Serosa, Inflammation, Necrotizing    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Fat, Granuloma                       |                                                                         3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Edema                                |                                                                          |             
      Acinus, Atrophy                      |    3        2     2        2  1           3  3           2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Muscularis, Necrosis, Focal          |                                                                          |             
      Muscularis, Necrosis                 |                                                                          |             
      Serosa, Inflammation, Suppurative    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               2  2                    3  3  2     3  3   |             
      Edema                                |                                                          3               |             
      Hyperkeratosis                       |                               2  2                    3  3  2     3      |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Degeneration                 |                                        3                                 |             
      Mucosa, Erosion, Focal               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1  1     2  2  2  3     2  3  3  2     2  2  2  3  2  2  2  2  2  2|             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           |                               3           2        2  3     3            |             
      Degeneration                         |                                                                          |             
      Hyperplasia, Focal                   |                                        1        2           1            |             
      Hypertrophy, Focal                   |                                                                          |             
      Metaplasia, Focal, Osseous           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                        2                          2      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                               +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Hypertrophy                          |                                        3     2           2        3  3   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                  4                                       |             
      Pigmentation                         |                                                                          |             
      Pars Distalis, Cyst                  |                            X                                             |             
      Pars Distalis, Hyperplasia, Focal    |    1  1  1           1     1                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                               3              3     2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          +                                                               |             
      Hemorrhage                           |          3                                                               |             
      Inflammation, Proliferative          |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  |                                  3     3     2  2  3  3  3  2  1  3  3   |             
      Fibrosis                             |                                        3                          2      |             
                                            __________________________________________________________________________|             
   Penis                                   |                                        +                                 |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  M  +  +  +  +  M|             
      Abscess                              |                                                                          |             
      Ectasia                              |                               2                                          |             
      Fibrosis                             |                                  3     2           2  2           3  2   |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                        2     3     2                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                    2                     |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Suppurative            |                               3  3  3                 3  3  3           3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        3              3  3               |             
      Depletion Cellular                   |                            4                                      4      |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
      Polyarteritis                        |                                                                      3   |             
      Interstitial Cell, Hyperplasia       |                                                    2                     |             
      Seminiferous Tubule, Atrophy         |                                  1     3        3  3     3           4   |             
      Seminiferous Tubule, Degeneration    |                                                       4           3      |             
      Unilateral, Atrophy                  |    4        4                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +  I  +  +  +|             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  3                          3            |             
      Fibrosis                             |                                                             2            |             
      Hematopoietic Cell Proliferation     |                                        3           1                     |             
      Infarct                              |                                                                         3|             
      Pigmentation, Hemosiderin            | 2  2  2  1  2  2  2  2  1                          2  2           2  2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +     +  M  A  +  +  M  +  +  +  M  +  +  +  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Depletion Lymphoid                   |                                        3                          3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +     +  +  M  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                4                                                         |             
      Hyperplasia                          |                                        3                                 |             
      Lactation                            |                               X  X     X        X  X  X  X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Subcutaneous Tissue, Edema|                                                                          |             
      Other, Inflammation, Suppurative     |                                                                          |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    1  1  1  1  1  1        1        1        2                 1        1|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                        X     X                    X  X   |             
      Hyperostosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Diaphragm, Inflammation,             |                                                                          |             
          Proliferative                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               X                             X            |             
      Hemorrhage                           |                               3                                          |             
      Hydrocephalus                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2           2     2     2        2         |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic                |                                                       3  1               |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               | 3                    4                                                   |             
      Infiltration Cellular, Mixed Cell    |    3                                                                     |             
      Inflammation, Chronic                |                                                    2           2         |             
      Inflammation, Suppurative            |                                  2                                       |             
      Nasolacrimal Duct, Exudate           |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 6| 4| 7| 5| 7| 7| 7| 7| 5| 6| 6| 6| 7| 5|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 1| 4| 6| 3| 3| 5| 3| 3| 3| 0| 3| 4| 5| 4| 2| 3|             
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 3| 5| 7| 7| 5| 9| 5| 5| 5| 8| 8| 5| 4| 7| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                 2                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
      Submucosa, Olfactory Epithelium,     |                                                                          |             
           Glands, Hypertrophy             |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                               +        +        +                        |             
      Ulcer                                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                               +  +     +  +  +  +  +  +     +  +  +  +  +|             
      Cataract                             |                               3  3     2  2  3  3  3  3     3  3  3  3  3|             
      Hemorrhage                           |                                                                          |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                               3                                          |             
      Retina, Atrophy                      |                                  3     2  3  3  2  2  3           3  2   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 3  3  3  3  2  3  3  3  3  2  2  2  2  4  3  3  2  3  4  4  3  3  4  4  2|             
      Pelvis, Epithelium, Hyperplasia      | 2                                2     2     3     4  3                  |             
      Pelvis, Epithelium, Mineralization   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +     +  +  A  +  M  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                         2|             
      Mucosa, Hyperplasia                  |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|             
                             DAY ON TEST   | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|             
                                           | 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    300 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       | 2                                                  2                 2   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  A  +  +  +  A|             
      Edema                                |             3                                                            |             
      Ulcer                                |             3                                3                           |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  A  +  +  +  A|             
      Edema                                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  A  A  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
      Ulcer                                |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  A  A  A  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  A  A  A  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Degeneration, Cystic, Focal          |                                                                          |             
      Degeneration, Fatty, Focal           |                                                                          |             
      Degeneration, Fatty                  |                                                             1            |             
      Fibrosis, Focal                      |                                                                         2|             
      Hematopoietic Cell Proliferation     |                                                                1         |             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Inflammation, Chronic, Focal         |          2     2                          3                              |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Necrosis                             | 2     2  2        4                          2  3                        |             
      Bile Duct, Hyperplasia               |    2  2     3        1  2  2  2     2  2     2  2  2  2  2  2  2     2   |             
      Centrilobular, Degeneration, Fatty   |                                                                          |             
      Midzonal, Degeneration, Fatty        | 2                                                                        |             
      Peripheral, Degeneration, Fatty      |                                                                      3   |             
      Serosa, Inflammation, Necrotizing    | 3                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Granuloma                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Cytoplasmic Alteration, Focal        |                                              2                           |             
      Edema                                |             3                                                            |             
      Acinus, Atrophy                      |    1  3  1  3  2  1     2           2  3  1        3     1     3  3      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                               3                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Muscularis, Necrosis, Focal          |                3                                                         |             
      Muscularis, Necrosis                 |                            2                                             |             
      Serosa, Inflammation, Suppurative    | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|             
                             DAY ON TEST   | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|             
                                           | 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    300 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Acanthosis                           | 4     2     2        2  4  3        3  3     3     2                 2   |             
      Edema                                | 2                    2                 3           2                 2   |             
      Hyperkeratosis                       | 3     2  3  2        2  4  3        3  3     2     2                 2   |             
      Ulcer                                | 2                       3              3           4                 3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Mucosa, Degeneration                 |                3           3                    3                        |             
      Mucosa, Erosion, Focal               |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +           +                                             |             
      Degeneration                         |                3           3                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1  2     3  1  2  2  3  2  2  2  2  2  1  3  2  1  2  2  3  2  1   |             
      Atrium, Thrombosis                   |             X                                   X                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty, Focal           | 2                    2     2     2  4  2        3     2     2            |             
      Degeneration                         |                                                                          |             
      Hyperplasia, Focal                   |                            2                       2                     |             
      Hypertrophy, Focal                   |                                                                          |             
      Metaplasia, Focal, Osseous           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |       2  2  2  3  3  2     2                       2           2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                    1                     |             
      Hypertrophy                          | 2     3        4  1  2  2  4  2     3           3  3                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            2                                             |             
      Hemorrhage                           |                               4                                          |             
      Pigmentation                         |                            3                                             |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |       2                    2              2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      C-Cell, Hyperplasia                  |       1  2                    2                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Proliferative          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|             
                             DAY ON TEST   | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|             
                                           | 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    300 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Focal                  | 2     3     4  3  3     2              3  4  3  3  3        3        4   |             
      Fibrosis                             |       2     2  2                       2  3              2               |             
                                            __________________________________________________________________________|             
   Penis                                   |                +                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                     4                                3   |             
      Ectasia                              |             2                                                  3         |             
      Fibrosis                             | 2     3     3  2           2        2     2  2  2  3        2  2     3   |             
      Hyperplasia                          |    3                                                                     |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                          2               |             
      Inflammation, Chronic                |                                     2     2                              |             
      Inflammation, Suppurative            | 3        3     3  4  3  3  4     3              4     3     3     3      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Atrophy                              | 3     2     2                       3              2        2            |             
      Depletion Cellular                   |                3  2  3     3              4     3                        |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                                          |             
      Polyarteritis                        |                            3        3                                    |             
      Interstitial Cell, Hyperplasia       |       3                                      1                           |             
      Seminiferous Tubule, Atrophy         |       4        4  2        3        3  1  2  2     2        2     3      |             
      Seminiferous Tubule, Degeneration    |             3        3                          3        3               |             
      Unilateral, Atrophy                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                                                             1            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hemorrhage              |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Granulomatous          |             3                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Congestion                           |                                                                      4   |             
      Fibrosis                             |                         3                                                |             
      Hematopoietic Cell Proliferation     |                   4     2                       3              3         |             
      Infarct                              |                                              4                           |             
      Pigmentation, Hemosiderin            |       2  2           3              2              3     2  2     2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  +  M  +  +  +  +  I  +  +  +  +  +  I  +  +  M  M  M  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|             
                             DAY ON TEST   | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|             
                                           | 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    300 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Depletion Lymphoid                   | 2              3     2                 2        3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |                3                                                         |             
      Lactation                            | X  X  X  X     X  X     X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abdominal, Subcutaneous Tissue, Edema|                                                                          |             
      Other, Inflammation, Suppurative     |                                                    2                     |             
                                            __________________________________________________________________________|             
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |    1        1  1  1  1        1  1     1              1  1        2      |             
      Hyperkeratosis                       |                      2                                                   |             
      Inflammation, Suppurative            |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |       X        X     X     X                    X  X                     |             
      Hyperostosis                         |                                              X                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
      Diaphragm, Inflammation,             |                                                                          |             
          Proliferative                    | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          X                          X                       X  X        X|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2  3  2     2           2  2  3     2     4|             
      Edema                                |                                                                         4|             
      Hemorrhage                           |                2                                                         |             
      Infiltration Cellular, Histiocyte    |                                                                         2|             
      Inflammation, Chronic                |       2        3  1  2     2                    2                    2   |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |       X                                         X        X        X      |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Chronic                |                   2     2                 2                              |             
      Inflammation, Suppurative            |          3     2                    2                 2              1   |             
      Nasolacrimal Duct, Exudate           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 6| 5| 7| 7| 5| 6| 5| 6| 7| 5| 6| 6| 5| 6| 7| 6| 5| 6| 6| 6| 5| 6| 3|             
                             DAY ON TEST   | 6| 9| 8| 4| 3| 1| 4| 5| 8| 9| 0| 1| 9| 2| 1| 3| 0| 6| 2| 3| 0| 1| 3| 5| 9|             
                                           | 2| 6| 9| 9| 4| 8| 2| 0| 2| 9| 0| 9| 9| 6| 2| 2| 8| 5| 8| 7| 7| 5| 4| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    300 UL                                 | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Suppurative                     |                      2  2                                                |             
      Submucosa, Olfactory Epithelium,     |                                                                          |             
           Glands, Hypertrophy             |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +     +  +  +  +  +  +  +     +  +  +     +  +  +  +  +   |             
      Cataract                             | 3  2  3  2  3  3     3  3  3  2  3  3  3     3  3  3     3  3  3  3  3   |             
      Hemorrhage                           |                3                                                         |             
      Anterior Chamber, Inflammation,      |                                                                          |             
          Suppurative                      |                                                                          |             
      Retina, Atrophy                      | 3     2  3  3  2     3  2  2  3  3  2  3     3  2  3     4     3  3  4   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 4  2  4  3  2  4  2  4  4  4  3  2  4  2  2  2  4  4  2  2  2  2  1  2  3|             
      Pelvis, Epithelium, Hyperplasia      |    2  3     2  3        2  3  2     2     1  2                           |             
      Pelvis, Epithelium, Mineralization   |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 5| 6| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6|                                            |            |
                                           | 8| 6| 4| 8| 5| 1| 2| 4| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperkeratosis                       |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  A  +                                             |  50        |
      Edema                                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +                                             |  53        |
      Edema                                |          2                                                               |      2  2.5|
      Parasite Metazoan                    |                                                                          |      1     |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Ulcer                                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  M  +  +  +  +  +                                             |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Clear Cell Focus                     |                                                                          |      1     |
      Degeneration, Cystic, Focal          |                                                                          |      2  2.0|
      Degeneration, Fatty, Focal           |                                                                          |      1  2.0|
      Degeneration, Fatty                  |                                                                          |      2  1.0|
      Fibrosis, Focal                      |                2                                                         |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation, Chronic, Focal         |       2     2           1                                                |     12  1.9|
      Inflammation, Focal, Granulomatous   |                                                                          |      7  1.9|
      Necrosis                             |                                                                          |      6  2.5|
      Bile Duct, Hyperplasia               | 2  2  2  3  2  2  3     2                                                |     47  2.1|
      Centrilobular, Degeneration, Fatty   |                                                                          |      1  2.0|
      Midzonal, Degeneration, Fatty        |                                                                          |      1  2.0|
      Peripheral, Degeneration, Fatty      |                                                                          |      1  3.0|
      Serosa, Inflammation, Necrotizing    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Granuloma                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Edema                                |          2                                                               |      2  2.5|
      Acinus, Atrophy                      | 3  1  3        3                                                         |     26  2.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 5| 6| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6|                                            |            |
                                           | 8| 6| 4| 8| 5| 1| 2| 4| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Concretion                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Muscularis, Necrosis, Focal          |                                                                          |      1  3.0|
      Muscularis, Necrosis                 |                                                                          |      1  2.0|
      Serosa, Inflammation, Suppurative    |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acanthosis                           | 2           1  3  3  3     2                                             |     24  2.6|
      Edema                                |                2  2  2     2                                             |     10  2.2|
      Hyperkeratosis                       | 2           1  3  3  3     2                                             |     24  2.5|
      Ulcer                                |                4  2        4                                             |      8  3.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Mucosa, Degeneration                 |                                                                          |      4  3.0|
      Mucosa, Erosion, Focal               |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Degeneration                         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cardiomyopathy                       | 2  2        2  2     2  2  1                                             |     52  2.0|
      Atrium, Thrombosis                   |                   X                                                      |      3     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Degeneration, Fatty, Focal           | 2                                                                        |     15  2.4|
      Degeneration                         |                1                                                         |      1  1.0|
      Hyperplasia, Focal                   | 3     2                 1                                                |      8  1.8|
      Hypertrophy, Focal                   |                2                                                         |      1  2.0|
      Metaplasia, Focal, Osseous           |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Focal                   |       1  4           2                                                   |     14  2.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  49        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +                                             |  57        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Hypertrophy                          | 2                    3     2                                             |     19  2.6|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 5| 6| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6|                                            |            |
                                           | 8| 6| 4| 8| 5| 1| 2| 4| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pigmentation                         |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                   2  2                                                   |     10  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +                                             |  57        |
      C-Cell, Hyperplasia                  |                         1  1                                             |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |          +                                                               |   2        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Proliferative          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Degeneration, Focal                  | 4  1           2  3  3  1  2                                             |     31  2.7|
      Fibrosis                             | 3        2        2                                                      |     11  2.3|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  M  +                                             |  54        |
      Abscess                              |                                                                          |      2  3.5|
      Ectasia                              |                3                                                         |      4  2.5|
      Fibrosis                             | 2        2     2  3  2                                                   |     24  2.3|
      Hyperplasia                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |          4                                                               |      1  4.0|
      Hyperplasia, Focal                   |       2                                                                  |      3  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |    2     3  3  4  4  3  4  3                                             |     27  3.2|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              | 2              2           3                                             |     12  2.5|
      Depletion Cellular                   |          3           3                                                   |     10  3.2|
      Inflammation, Suppurative            |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hypoplasia                           | 2                                                                        |      1  2.0|
      Polyarteritis                        |       3                                                                  |      4  3.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      3  2.0|
      Seminiferous Tubule, Atrophy         |       3        2     2                                                   |     20  2.6|
      Seminiferous Tubule, Degeneration    |          3        3                                                      |      8  3.1|
      Unilateral, Atrophy                  |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 5| 6| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6|                                            |            |
                                           | 8| 6| 4| 8| 5| 1| 2| 4| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hypoplasia                           | 2  2                                                                     |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                                                                          |      3  3.3|
      Fibrosis                             |          4        3                                                      |      4  3.0|
      Hematopoietic Cell Proliferation     |       2                                                                  |      7  2.6|
      Infarct                              |                                                                          |      2  3.5|
      Pigmentation, Hemosiderin            |    2        2                                                            |     23  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  44        |
      Depletion Lymphoid                   |                                                                          |      7  2.6|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +  +  +  +  M  +  +                                             |  52        |
      Hyperplasia, Cystic                  |                                                                          |      1  4.0|
      Hyperplasia                          |                                                                          |      2  3.0|
      Lactation                            |       X  X  X  X        X  X                                             |     40     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abdominal, Subcutaneous Tissue, Edema|                   3                                                      |      1  3.0|
      Other, Inflammation, Suppurative     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin, Control                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Skin, Site of Application-No Mass       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |    1     1  1        1  1                                                |     27  1.1|
      Hyperkeratosis                       |          1                                                               |      2  1.5|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Fibrous Osteodystrophy               |                      X                                                   |     11     |
      Hyperostosis                         |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Diaphragm, Inflammation,             |                                                                          |            |
          Proliferative                    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 5| 6| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6|                                            |            |
                                           | 8| 6| 4| 8| 5| 1| 2| 4| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Compression                          | X                          X                                             |      9     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           | 2  2        2           3                                                |     19  2.2|
      Edema                                |                                                                          |      1  4.0|
      Hemorrhage                           | 1                                                                        |      2  1.5|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                | 1     3                                                                  |     11  2.0|
      Alveolar Epithelium, Hyperplasia     |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Fungus                               |                   X                                                      |      7  3.5|
      Infiltration Cellular, Mixed Cell    |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      5  2.0|
      Inflammation, Suppurative            |          3                                                               |      7  2.1|
      Nasolacrimal Duct, Exudate           |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      2  2.0|
      Submucosa, Olfactory Epithelium,     |                                                                          |            |
           Glands, Hypertrophy             |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Eye                                     | +     +  +  +  +  +     +  +                                             |  42        |
      Cataract                             | 3     3  3  3  3  3     3  3                                             |     42  2.9|
      Hemorrhage                           |                                                                          |      1  3.0|
      Anterior Chamber, Inflammation,      |                                                                          |            |
          Suppurative                      |                                                                          |      1  3.0|
      Retina, Atrophy                      | 3        3  3  3        3  2                                             |     34  2.7|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05106-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          DIETHYLPHTHALATE                                     Date: 04/24/97  
Route: SKIN APPLICATION                                                                                           Time: 16:40:05  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 4| 7| 7| 5| 6| 6| 5| 5| 5|                                            |            |
                             DAY ON TEST   | 6| 8| 3| 2| 3| 4| 1| 3| 8| 6|                                            |            |
                                           | 8| 6| 4| 8| 5| 1| 2| 4| 0| 3|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS MALE                   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      A     |
    300 UL                                 | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |      L     |
    RAT HM                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Nephropathy                          | 3  2  3  2  2  4  3  4  2  3                                             |     60  2.9|
      Pelvis, Epithelium, Hyperplasia      | 2     2  2        2  2     1                                             |     22  2.2|
      Pelvis, Epithelium, Mineralization   |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------