National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1859

TDMS Study 05107-06 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         NICKEL SUBSULFIDE


NTP Experiment-Test: 05107-06                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  12035722

       Lock Date:  10/14/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           20           60           20           60           20           
  Scheduled Sacrifice                                  2           18                        20            2           18           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14                        15                        11            2           
    Natural Death                                      8                        11                         9                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                36                        34                        38                        
  Other                                                             2                                                               
  Animals Examined Microscopically                    58           10           60           10           58           12           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (53)         (5)          (51)         (5)          (51)         (7)          
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Intestine Large, Cecum                             (54)         (5)          (54)         (5)          (53)         (7)          
      Hyperplasia, Lymphoid                                         1 (20%)                   2 (40%)                   2 (29%)     
      Lymphoid Tissue, Hyperplasia, Lymphoid           1 (2%)                    2 (4%)                                             
   Intestine Small, Duodenum                          (53)         (5)          (53)         (5)          (51)         (7)          
      Atrophy                                          1 (2%)                                                                       
      Inflammation                                                               2 (4%)                                             
   Intestine Small, Jejunum                           (54)         (5)          (53)         (5)          (51)         (7)          
      Atrophy                                          1 (2%)                                                                       
   Intestine Small, Ileum                             (54)         (5)          (52)         (5)          (52)         (7)          
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia                                                   1 (20%)                                                         
      Hyperplasia, Lymphoid                                         1 (20%)                                                         
      Peyer's Patch, Hyperplasia, Lymphoid                                       1 (2%)                                             
   Liver                                              (58)         (5)          (60)         (5)          (58)         (7)          
      Angiectasis                                      3 (5%)                    1 (2%)                    3 (5%)                   
      Atrophy                                                                    4 (7%)                    1 (2%)       1 (14%)     
      Basophilic Focus                                              1 (20%)      1 (2%)                    1 (2%)                   
      Cyst                                             1 (2%)                                                                       
      Degeneration                                     1 (2%)                    1 (2%)                    3 (5%)                   
      Eosinophilic Focus                                                         1 (2%)                    3 (5%)                   
      Fibrosis                                         1 (2%)                                                                       
      Infarct                                          1 (2%)                    2 (3%)                    2 (3%)                   
      Infiltration Cellular, Lymphocyte                2 (3%)                    2 (3%)                    3 (5%)                   
      Inflammation                                     4 (7%)                    3 (5%)                    1 (2%)                   
      Mixed Cell Focus                                                           1 (2%)                    1 (2%)                   
      Necrosis                                         2 (3%)                    3 (5%)                    1 (2%)                   
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
   Mesentery                                          (3)                       (4)                       (1)                       
      Inflammation                                                               1 (25%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Necrosis                                         1 (33%)                                                                      
      Artery, Inflammation                             1 (33%)                                                                      
   Pancreas                                           (58)         (5)          (56)         (5)          (57)         (7)          
      Atrophy, Focal                                   2 (3%)                                                                       
      Cyst                                                                       1 (2%)                                             
      Infiltration Cellular, Lymphocyte                1 (2%)                    3 (5%)                                             
      Inflammation                                                               1 (2%)                    1 (2%)                   
      Acinus, Atrophy                                  2 (3%)                    1 (2%)                    1 (2%)                   
   Stomach, Forestomach                               (57)         (5)          (60)         (5)          (56)         (7)          
      Hyperplasia, Focal, Squamous                                                                         1 (2%)                   
      Hyperplasia, Squamous                            2 (4%)                                                                       
      Inflammation                                                                                         1 (2%)                   
   Stomach, Glandular                                 (57)         (5)          (58)         (5)          (56)         (7)          
      Inflammation                                     2 (4%)                    5 (9%)                    4 (7%)                   
   Tooth                                              (2)                       (1)                       (1)                       
      Developmental Malformation                                                 1 (100%)                  1 (100%)                 
      Inflammation                                     2 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (58)         (5)          (60)         (5)          (57)         (7)          
      Cardiomyopathy                                                             1 (2%)                                 1 (14%)     
      Inflammation                                     1 (2%)                                                                       
      Artery, Inflammation                             1 (2%)                                                                       
      Atrium, Thrombosis                               2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (58)         (5)          (58)         (5)          (58)         (7)          
      Angiectasis                                      1 (2%)                    1 (2%)                    2 (3%)                   
      Atrophy                                                                    1 (2%)                    1 (2%)                   
      Degeneration                                                                                         1 (2%)       2 (29%)     
      Hematopoietic Cell Proliferation                                                                     1 (2%)                   
      Hyperplasia                                                                                          1 (2%)                   
      Hyperplasia, Focal                                                         1 (2%)                                             
   Adrenal Medulla                                    (58)         (5)          (58)         (5)          (58)         (7)          
      Angiectasis                                      1 (2%)                    2 (3%)                    1 (2%)                   
      Hyperplasia                                                                                          1 (2%)                   
   Pituitary Gland                                    (58)         (4)          (57)         (5)          (58)         (7)          
      Angiectasis                                      2 (3%)                    6 (11%)                   1 (2%)                   
      Cyst                                             1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       7 (12%)                  10 (18%)                  11 (19%)                  
   Thyroid Gland                                      (58)         (5)          (60)         (5)          (58)         (7)          
      Inflammation                                                                                         1 (2%)                   
      Artery, Inflammation                             1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Follicle, Atrophy                                1 (2%)                                                                       
      Follicular Cell, Hyperplasia                    20 (34%)                  28 (47%)                  37 (64%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (4)                       (1)          (1)          
      Thoracic, Inflammation                                                                               1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (55)         (5)          (59)         (5)          (51)         (5)          
      Atrophy                                                                    1 (2%)                    8 (16%)                  
      Ectasia                                          2 (4%)       1 (20%)      1 (2%)                                 1 (20%)     
      Inflammation                                                               2 (3%)                                             
   Ovary                                              (58)         (4)          (58)         (5)          (58)         (7)          
      Abscess                                                                    1 (2%)                    1 (2%)                   
      Cyst                                             6 (10%)                   8 (14%)                  11 (19%)                  
      Hemorrhage                                                                                           1 (2%)                   
      Periovarian Tissue, Cyst                                                                             1 (2%)                   
   Uterus                                             (58)         (5)          (60)         (5)          (58)         (8)          
      Abscess                                          1 (2%)                    1 (2%)                                             
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                             5 (9%)                    3 (5%)                    3 (5%)                   
      Cyst, Multiple                                                             2 (3%)                                             
      Inflammation                                                               1 (2%)                    3 (5%)                   
      Endometrium, Hyperplasia                        14 (24%)      3 (60%)     19 (32%)      2 (40%)     19 (33%)      3 (38%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (57)         (5)          (60)         (5)          (57)         (7)          
      Inflammation                                     1 (2%)                                                                       
      Erythroid Cell, Hyperplasia                                                3 (5%)                    1 (2%)                   
      Myeloid Cell, Atrophy                                                      1 (2%)                                             
      Myeloid Cell, Hyperplasia                        7 (12%)                   7 (12%)                   5 (9%)                   
   Lymph Node                                         (9)                       (12)         (1)          (11)                      
      Pigmentation                                                                            1 (100%)                              
      Iliac, Hyperplasia, Lymphoid                                               1 (8%)                    2 (18%)                  
      Inguinal, Hyperplasia, Lymphoid                  1 (11%)                                                                      
      Inguinal, Inflammation                           1 (11%)                                                                      
      Pancreatic, Hyperplasia                                                                              1 (9%)                   
      Pancreatic, Inflammation                         1 (11%)                   1 (8%)                    1 (9%)                   
      Renal, Hyperplasia, Lymphoid                                               2 (17%)                   3 (27%)                  
      Renal, Inflammation                                                        1 (8%)                                             
      Renal, Inflammation, Granulomatous                                         1 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Lymph Node, Bronchial                              (50)         (10)         (57)         (9)          (58)         (11)         
      Hyperplasia, Lymphoid                           10 (20%)                  46 (81%)      6 (67%)     51 (88%)      6 (55%)     
      Hyperplasia, Macrophage                                                   44 (77%)      6 (67%)     47 (81%)      6 (55%)     
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
   Lymph Node, Mandibular                             (57)         (7)          (59)         (7)          (58)         (10)         
      Hyperplasia                                                                                                       1 (10%)     
      Hyperplasia, Lymphoid                           18 (32%)      4 (57%)      7 (12%)      2 (29%)      4 (7%)       3 (30%)     
      Hyperplasia, Plasma Cell                         2 (4%)                    1 (2%)                                             
      Inflammation                                     1 (2%)                                                                       
   Lymph Node, Mesenteric                             (55)         (5)          (54)         (5)          (55)         (7)          
      Ectasia                                          1 (2%)                                                                       
      Hyperplasia, Lymphoid                            4 (7%)                    4 (7%)                    6 (11%)      1 (14%)     
      Inflammation                                     3 (5%)                    1 (2%)                    2 (4%)                   
   Lymph Node, Mediastinal                            (15)                      (28)                      (29)         (3)          
      Hyperplasia, Lymphoid                            1 (7%)                                              4 (14%)      1 (33%)     
      Inflammation                                                                                         1 (3%)                   
   Spleen                                             (58)         (5)          (60)         (5)          (58)         (7)          
      Atrophy                                                                    1 (2%)                                 1 (14%)     
      Hematopoietic Cell Proliferation                14 (24%)      2 (40%)     15 (25%)                   8 (14%)      1 (14%)     
      Hyperplasia, Lymphoid                           17 (29%)                  27 (45%)                  19 (33%)                  
      Inflammation                                     1 (2%)                                                                       
      Lymphoid Follicle, Atrophy                       2 (3%)                                                                       
      Red Pulp, Atrophy                                1 (2%)                    1 (2%)                                             
   Thymus                                             (58)         (5)          (57)         (5)          (53)         (6)          
      Degeneration                                     8 (14%)                   5 (9%)                    7 (13%)      1 (17%)     
      Hyperplasia                                      2 (3%)                                                                       
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)         (5)          (59)         (5)          (58)         (7)          
      Hyperplasia                                      8 (14%)                  11 (19%)                   7 (12%)                  
      Hyperplasia, Cystic                              1 (2%)                                                                       
      Inflammation                                                                                         1 (2%)                   
   Skin                                               (58)         (5)          (60)         (5)          (58)         (7)          
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                                                                           1 (2%)                   
      Inflammation                                     3 (5%)                                                           1 (14%)     
      Pinna, Cyst Epithelial Inclusion                                                                     1 (2%)                   
      Pinna, Hyperkeratosis                                                                                1 (2%)                   
      Pinna, Inflammation                              2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (57)         (5)          (60)         (5)          (57)         (7)          
      Hyperostosis                                     1 (2%)                                              1 (2%)                   
      Inflammation                                     1 (2%)                                              1 (2%)                   
      Femur, Hyperostosis                             10 (18%)                   9 (15%)                  10 (18%)                  
      Maxilla, Hyperostosis                                                                                1 (2%)                   
      Tibia, Fracture                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (58)         (5)          (60)         (5)          (58)         (7)          
      Thalamus, Degeneration, Focal                                                                                     1 (14%)     
   Spinal Cord                                        (1)                                                 (1)                       
      Abscess                                                                                              1 (100%)                 
      Degeneration                                     1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (54)         (4)          (55)         (4)          (51)         (6)          
      Inflammation                                                               1 (2%)                                             
      Inflammation, Chronic                                                                   1 (25%)                               
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Lung                                               (58)         (10)         (59)         (10)         (58)         (12)         
      Bronchiectasis                                                             1 (2%)                                             
      Fibrosis                                                                   7 (12%)                  17 (29%)                  
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                   46 (78%)      6 (60%)     56 (97%)     12 (100%)    
      Alveolar Epithelium, Hyperplasia                 3 (5%)                   53 (90%)      2 (20%)     57 (98%)      6 (50%)     
      Alveolus, Hyperplasia, Macrophage                5 (9%)       1 (10%)     57 (97%)     10 (100%)    58 (100%)    12 (100%)    
      Alveolus, Proteinosis                                                     54 (92%)      9 (90%)     58 (100%)    11 (92%)     
      Bronchus, Hyperplasia, Lymphoid                 34 (59%)      4 (40%)     26 (44%)      4 (40%)     34 (59%)      4 (33%)     
      Interstitium, Infiltration Cellular             19 (33%)      2 (20%)     53 (90%)     10 (100%)    57 (98%)     10 (83%)     
      Interstitium, Inflammation                       1 (2%)                                                                       
   Nose                                               (58)         (10)         (59)         (10)         (58)         (12)         
      Inflammation, Acute                                                       11 (19%)                  13 (22%)      1 (8%)      
      Olfactory Epithelium, Atrophy                    1 (2%)                   11 (19%)                  41 (71%)      1 (8%)      
      Olfactory Epithelium, Degeneration              26 (45%)      5 (50%)      3 (5%)                   12 (21%)                  
      Respiratory Epithelium, Degeneration             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (2)          (1)          (1)                       (2)                       
      Inflammation                                     1 (50%)                   1 (100%)                                           
      External Ear, Inflammation                       1 (50%)                                                                      
      External Ear, Ulcer                                           1 (100%)                                                        
   Eye                                                (2)                                                                           
      Cataract                                         1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (58)         (10)         (60)         (10)         (58)         (12)         
      Hydronephrosis                                                             1 (2%)                    1 (2%)                   
      Infarct                                          1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                9 (16%)                  12 (20%)                   1 (2%)                   
      Inflammation                                     1 (2%)                                                                       
      Metaplasia, Osseous                                                                                  1 (2%)                   
      Nephropathy                                      5 (9%)                    2 (3%)                    1 (2%)       1 (8%)      
      Glomerulus, Inflammation                                                                                          1 (8%)      
      Pelvis, Inflammation                                                                                 1 (2%)                   
      Renal Tubule, Pigmentation, Hemosiderin                                                              1 (2%)                   
   Urinary Bladder                                    (56)         (5)          (55)         (5)          (57)         (7)          
      Infiltration Cellular, Lymphocyte                1 (2%)                    3 (5%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           20           60           20           60           20           
  Scheduled Sacrifice                                  1           18            2           18            2           18           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                27                        25            1           25            1           
    Natural Death                                      6            2            8            1            8            1           
  Survivors                                                                                                                         
    Terminal Sacrifice                                26                        25                        25                        
  Animals Examined Microscopically                    59           12           59           11           58           12           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (56)         (6)          (50)         (5)          (53)         (5)          
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Intestine Large, Cecum                             (56)         (6)          (54)         (5)          (54)         (6)          
      Hyperplasia, Focal, Lymphoid                                               1 (2%)       1 (20%)                               
      Lymphoid Tissue, Hyperplasia                                               1 (2%)                                             
      Lymphoid Tissue, Hyperplasia, Lymphoid           1 (2%)                                              3 (6%)                   
   Intestine Small, Ileum                             (55)         (5)          (51)         (5)          (54)         (6)          
      Peyer's Patch, Hyperplasia, Lymphoid                                                                 3 (6%)                   
   Liver                                              (59)         (7)          (58)         (6)          (57)         (7)          
      Angiectasis                                      1 (2%)       1 (14%)      3 (5%)                    1 (2%)                   
      Atrophy                                                       1 (14%)      1 (2%)                    2 (4%)                   
      Basophilic Focus                                 2 (3%)                    1 (2%)                    1 (2%)       1 (14%)     
      Degeneration                                     1 (2%)                                 1 (17%)                               
      Eosinophilic Focus                               2 (3%)                    2 (3%)                                             
      Hepatodiaphragmatic Nodule                                                 2 (3%)                                             
      Infarct                                          2 (3%)                    2 (3%)                    2 (4%)                   
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation                                     2 (3%)                                                                       
      Mixed Cell Focus                                 1 (2%)                                              1 (2%)       1 (14%)     
      Necrosis                                         7 (12%)                   9 (16%)                   5 (9%)       1 (14%)     
      Pigmentation, Hemosiderin                                                  1 (2%)                    1 (2%)                   
      Regeneration                                                               1 (2%)                                             
      Bile Duct, Hyperplasia                                                     1 (2%)                                             
      Sinusoid, Cyst                                                                                       1 (2%)                   
   Pancreas                                           (59)         (7)          (58)         (6)          (56)         (7)          
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Acinus, Atrophy                                  1 (2%)                    1 (2%)                                             
      Acinus, Hyperplasia                              1 (2%)                                                                       
   Stomach, Forestomach                               (59)         (5)          (58)         (6)          (55)         (7)          
      Hyperplasia, Focal                                                                      1 (17%)                               
      Inflammation                                                               1 (2%)                                             
   Stomach, Glandular                                 (59)         (7)          (58)         (6)          (55)         (7)          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Degeneration                                                                                         1 (2%)                   
      Hyperplasia, Focal                                                                      1 (17%)                               
      Inflammation                                     1 (2%)                    2 (3%)                                             
   Tooth                                              (4)                       (1)                       (4)                       
      Developmental Malformation                       1 (25%)                                             2 (50%)                  
      Inflammation                                     3 (75%)                   1 (100%)                  1 (25%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (59)         (7)          (58)         (6)          (58)         (7)          
      Angiectasis                                                                                          1 (2%)                   
      Cardiomyopathy                                   1 (2%)                    2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (59)         (7)          (58)         (6)          (56)         (7)          
      Cyst                                             1 (2%)                                                                       
      Degeneration                                                               1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)                    2 (3%)                    4 (7%)                   
      Hypertrophy                                                   1 (14%)                                                         
      Hypertrophy, Focal                                                         1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
   Islets, Pancreatic                                 (59)         (7)          (58)         (6)          (56)         (7)          
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (56)         (7)          (57)         (6)          (53)         (7)          
      Pars Distalis, Hyperplasia                       1 (2%)                                              1 (2%)                   
   Thyroid Gland                                      (59)         (7)          (58)         (6)          (57)         (7)          
      Follicular Cell, Hyperplasia                    27 (46%)                  25 (43%)                  24 (42%)      1 (14%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Penis                                              (12)                      (9)                       (8)                       
      Concretion                                       4 (33%)                   2 (22%)                   1 (13%)                  
      Inflammation                                     5 (42%)                   6 (67%)                   6 (75%)                  
   Preputial Gland                                    (59)         (7)          (58)         (5)          (58)         (7)          
      Atrophy                                          3 (5%)                    1 (2%)                    1 (2%)                   
      Ectasia                                         27 (46%)      5 (71%)     31 (53%)      5 (100%)    41 (71%)      4 (57%)     
      Hyperplasia                                      2 (3%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                           24 (41%)      1 (14%)     15 (26%)                   7 (12%)      1 (14%)     
   Prostate                                           (59)         (7)          (58)         (6)          (57)         (7)          
      Inflammation                                                               1 (2%)                    2 (4%)                   
   Seminal Vesicle                                    (59)         (7)          (58)         (6)          (57)         (7)          
      Hyperplasia                                      2 (3%)                                                                       
   Testes                                             (59)         (7)          (58)         (6)          (57)         (7)          
      Atrophy                                          1 (2%)                                              2 (4%)                   
      Germinal Epithelium, Atrophy                                               2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (7)          (58)         (6)          (57)         (7)          
      Thrombosis                                                                                           1 (2%)                   
      Erythroid Cell, Hyperplasia                      2 (3%)                    3 (5%)                    1 (2%)                   
      Myeloid Cell, Hyperplasia                       23 (39%)                  11 (19%)                  14 (25%)      1 (14%)     
   Lymph Node                                         (18)         (1)          (11)         (2)          (10)         (1)          
      Iliac, Hyperplasia, Lymphoid                     3 (17%)                                             3 (30%)                  
      Iliac, Hyperplasia, Plasma Cell                  7 (39%)                   1 (9%)                    3 (30%)                  
      Iliac, Inflammation                              1 (6%)                    1 (9%)                                             
      Iliac, Pigmentation                              2 (11%)                   1 (9%)                    1 (10%)                  
      Inguinal, Hyperplasia, Lymphoid                  6 (33%)                   5 (45%)      1 (50%)      6 (60%)                  
      Inguinal, Hyperplasia, Plasma Cell               2 (11%)                   3 (27%)                                            
      Inguinal, Inflammation                                                     1 (9%)                                             
      Inguinal, Pigmentation                           1 (6%)                                                           1 (100%)    
      Lumbar, Hyperplasia, Lymphoid                                 1 (100%)                  1 (50%)                               
      Lumbar, Hyperplasia, Plasma Cell                 1 (6%)                                                                       
      Lumbar, Pigmentation                             1 (6%)       1 (100%)     1 (9%)       1 (50%)                               
      Pancreatic, Hyperplasia, Lymphoid                                          1 (9%)                                             
      Renal, Hyperplasia, Lymphoid                     1 (6%)                                                                       
      Renal, Hyperplasia, Plasma Cell                  1 (6%)                                                                       
   Lymph Node, Bronchial                              (39)         (8)          (53)         (7)          (53)         (11)         
      Hyperplasia, Lymphoid                            4 (10%)                  40 (75%)      5 (71%)     49 (92%)      8 (73%)     
      Hyperplasia, Macrophage                          1 (3%)                   47 (89%)      5 (71%)     49 (92%)     10 (91%)     
      Hyperplasia, Plasma Cell                         1 (3%)                                                                       
   Lymph Node, Mandibular                             (51)         (3)          (51)         (4)          (55)         (6)          
      Hyperplasia, Lymphoid                            3 (6%)                                              1 (2%)       1 (17%)     
      Hyperplasia, Plasma Cell                         1 (2%)                                                                       
   Lymph Node, Mesenteric                             (56)         (7)          (56)         (6)          (53)         (7)          
      Hemorrhage, Chronic                                           1 (14%)                                                         
      Hyperplasia, Lymphoid                            2 (4%)       1 (14%)      5 (9%)                    6 (11%)                  
      Hyperplasia, Macrophage                          1 (2%)                                                                       
      Inflammation                                     3 (5%)                    1 (2%)                                             
   Lymph Node, Mediastinal                            (12)         (3)          (18)         (3)          (17)         (5)          
      Hyperplasia                                                                             1 (33%)                               
      Hyperplasia, Lymphoid                            2 (17%)                   1 (6%)                    1 (6%)                   
      Hyperplasia, Macrophage                          1 (8%)                    1 (6%)                    1 (6%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Plasma Cell                                                   1 (6%)                                             
   Spleen                                             (59)         (7)          (57)         (6)          (55)         (7)          
      Atrophy                                                       1 (14%)      1 (2%)                    1 (2%)                   
      Hematopoietic Cell Proliferation                 8 (14%)                  11 (19%)      1 (17%)      5 (9%)                   
      Hyperplasia, Lymphoid                           16 (27%)                   8 (14%)                   7 (13%)      1 (14%)     
      Inflammation                                                                                         1 (2%)                   
   Thymus                                             (46)         (7)          (50)         (5)          (39)         (7)          
      Atrophy                                                                    1 (2%)                                             
      Degeneration                                    11 (24%)      1 (14%)     12 (24%)      1 (20%)     15 (38%)      1 (14%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (59)         (7)          (56)         (6)          (57)         (7)          
      Alopecia                                         1 (2%)                                              1 (2%)                   
      Fibrosis                                                      1 (14%)                                                         
      Inflammation                                     2 (3%)                                              2 (4%)                   
      Necrosis                                                      1 (14%)                                                         
      Parakeratosis                                                              1 (2%)                                             
      Ulcer                                                                                   1 (17%)                               
      Pinna, Hyperkeratosis                            1 (2%)                                                                       
      Prepuce, Hyperkeratosis                                                                              1 (2%)                   
      Prepuce, Inflammation                           16 (27%)                   9 (16%)                  13 (23%)                  
      Subcutaneous Tissue, Abscess                                                                                      1 (14%)     
      Tail, Hyperkeratosis                                                       1 (2%)                                             
      Tail, Inflammation                               1 (2%)                    1 (2%)                    1 (2%)                   
      Tail, Necrosis                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (59)         (7)          (58)         (6)          (57)         (7)          
      Developmental Malformation                                                 1 (2%)                                             
      Hyperostosis                                                               1 (2%)                                             
      Femur, Hyperostosis                                                                                               1 (14%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (7)          (58)         (6)          (57)         (7)          
      Cerebellum, White Matter, Degeneration, Focal                              1 (2%)                                             
      Medulla, Degeneration, Focal                                  1 (14%)                                             1 (14%)     
      Medulla, Demyelination                           1 (2%)                                                                       
   Spinal Cord                                                                               (1)                       (1)          
      Degeneration, Secondary Wallerian                                                       1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (59)         (12)         (58)         (11)         (56)         (12)         
      Autolysis                                                                                            1 (2%)                   
      Fibrosis                                                                   3 (5%)                   15 (27%)      1 (8%)      
      Infiltration Cellular                                                      1 (2%)                                             
      Inflammation, Acute                                                                                  2 (4%)                   
      Inflammation, Chronic Active                     1 (2%)                   52 (90%)      8 (73%)     52 (93%)     11 (92%)     
      Alveolar Epithelium, Hyperplasia                 3 (5%)                   53 (91%)      4 (36%)     54 (96%)      5 (42%)     
      Alveolar Epithelium, Metaplasia, Squamous                                                            1 (2%)                   
      Alveolus, Hyperplasia                                                                                1 (2%)                   
      Alveolus, Hyperplasia, Macrophage                6 (10%)                  57 (98%)     10 (91%)     56 (100%)    12 (100%)    
      Alveolus, Proteinosis                                                     57 (98%)     10 (91%)     56 (100%)    11 (92%)     
      Bronchus, Hyperplasia, Lymphoid                 21 (36%)      3 (25%)     29 (50%)      1 (9%)      14 (25%)      2 (17%)     
      Interstitium, Infiltration Cellular             10 (17%)                  54 (93%)     10 (91%)     53 (95%)     10 (83%)     
   Nose                                               (59)         (12)         (58)         (11)         (57)         (12)         
      Foreign Body                                                                                         1 (2%)                   
      Inflammation, Acute                                                                                  3 (5%)                   
      Olfactory Epithelium, Atrophy                    1 (2%)                   26 (45%)      5 (45%)     54 (95%)      9 (75%)     
      Olfactory Epithelium, Degeneration               3 (5%)                    8 (14%)                   6 (11%)                  
      Olfactory Epithelium, Respiratory Epithelium,                                                                                 
           Degeneration                                             1 (8%)                                                          
   Trachea                                            (59)         (6)          (58)         (6)          (56)         (7)          
      Inflammation, Focal                                           3 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (59)         (12)         (58)         (11)         (57)         (12)         
      Hydronephrosis                                   8 (14%)                   5 (9%)       1 (9%)       5 (9%)                   
      Infiltration Cellular, Lymphocyte                7 (12%)                   3 (5%)                    2 (4%)                   
      Inflammation                                     5 (8%)                    1 (2%)                    1 (2%)       1 (8%)      
      Nephropathy                                      9 (15%)                  10 (17%)                   6 (11%)      1 (8%)      
      Cortex, Atrophy                                                            2 (3%)                                             
      Cortex, Fibrosis                                                                                     1 (2%)                   
      Pelvis, Inflammation                             5 (8%)                    1 (2%)                    2 (4%)                   
      Renal Tubule, Atrophy                                                                                1 (2%)                   
      Renal Tubule, Degeneration                       1 (2%)                                                                       
      Renal Tubule, Necrosis                                                                               1 (2%)                   
   Ureter                                             (2)                                                                           
      Inflammation                                     2 (100%)                                                                     
   Urethra                                            (6)          (2)          (7)          (1)          (11)         (1)          
      Calculus Micro Observation Only                               2 (100%)                               2 (18%)      1 (100%)    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05107-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 05/19/95  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 22:48:31  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0MG/M3     0.0MG/M3     0.6MG/M3     0.6MG/M3     1.2MG/M3     1.2MG/M3        
                                                                LUNG TOX                  LUNG TOX                  LUNG TOX        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Concretion                                       5 (83%)                   6 (86%)      1 (100%)     8 (73%)                  
      Inflammation                                     1 (17%)                                             1 (9%)                   
   Urinary Bladder                                    (59)         (7)          (58)         (7)          (56)         (7)          
      Calculus Gross Observation                       1 (2%)                    2 (3%)                                 1 (14%)     
      Calculus Micro Observation Only                  1 (2%)       1 (14%)      1 (2%)       1 (14%)      2 (4%)                   
      Crystals                                         1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Inflammation                                    11 (19%)                   2 (3%)                    3 (5%)       1 (14%)     
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.