TDMS Study 05107-06 Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
NICKEL SUBSULFIDE
NTP Experiment-Test: 05107-06 Report: PEIRPT03
Study Type: CHRONIC Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 12035722
Lock Date: 10/14/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 20 60 20 60 20
Scheduled Sacrifice 2 18 20 2 18
Early Deaths
Moribund Sacrifice 14 15 11 2
Natural Death 8 11 9
Survivors
Terminal Sacrifice 36 34 38
Other 2
Animals Examined Microscopically 58 10 60 10 58 12
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (53) (5) (51) (5) (51) (7)
Epithelium, Hyperplasia 1 (2%)
Intestine Large, Cecum (54) (5) (54) (5) (53) (7)
Hyperplasia, Lymphoid 1 (20%) 2 (40%) 2 (29%)
Lymphoid Tissue, Hyperplasia, Lymphoid 1 (2%) 2 (4%)
Intestine Small, Duodenum (53) (5) (53) (5) (51) (7)
Atrophy 1 (2%)
Inflammation 2 (4%)
Intestine Small, Jejunum (54) (5) (53) (5) (51) (7)
Atrophy 1 (2%)
Intestine Small, Ileum (54) (5) (52) (5) (52) (7)
Atrophy 1 (2%)
Hyperplasia 1 (20%)
Hyperplasia, Lymphoid 1 (20%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (2%)
Liver (58) (5) (60) (5) (58) (7)
Angiectasis 3 (5%) 1 (2%) 3 (5%)
Atrophy 4 (7%) 1 (2%) 1 (14%)
Basophilic Focus 1 (20%) 1 (2%) 1 (2%)
Cyst 1 (2%)
Degeneration 1 (2%) 1 (2%) 3 (5%)
Eosinophilic Focus 1 (2%) 3 (5%)
Fibrosis 1 (2%)
Infarct 1 (2%) 2 (3%) 2 (3%)
Infiltration Cellular, Lymphocyte 2 (3%) 2 (3%) 3 (5%)
Inflammation 4 (7%) 3 (5%) 1 (2%)
Mixed Cell Focus 1 (2%) 1 (2%)
Necrosis 2 (3%) 3 (5%) 1 (2%)
Pigmentation, Hemosiderin 1 (2%)
Mesentery (3) (4) (1)
Inflammation 1 (25%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 1 (33%)
Artery, Inflammation 1 (33%)
Pancreas (58) (5) (56) (5) (57) (7)
Atrophy, Focal 2 (3%)
Cyst 1 (2%)
Infiltration Cellular, Lymphocyte 1 (2%) 3 (5%)
Inflammation 1 (2%) 1 (2%)
Acinus, Atrophy 2 (3%) 1 (2%) 1 (2%)
Stomach, Forestomach (57) (5) (60) (5) (56) (7)
Hyperplasia, Focal, Squamous 1 (2%)
Hyperplasia, Squamous 2 (4%)
Inflammation 1 (2%)
Stomach, Glandular (57) (5) (58) (5) (56) (7)
Inflammation 2 (4%) 5 (9%) 4 (7%)
Tooth (2) (1) (1)
Developmental Malformation 1 (100%) 1 (100%)
Inflammation 2 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (58) (5) (60) (5) (57) (7)
Cardiomyopathy 1 (2%) 1 (14%)
Inflammation 1 (2%)
Artery, Inflammation 1 (2%)
Atrium, Thrombosis 2 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (58) (5) (58) (5) (58) (7)
Angiectasis 1 (2%) 1 (2%) 2 (3%)
Atrophy 1 (2%) 1 (2%)
Degeneration 1 (2%) 2 (29%)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%)
Adrenal Medulla (58) (5) (58) (5) (58) (7)
Angiectasis 1 (2%) 2 (3%) 1 (2%)
Hyperplasia 1 (2%)
Pituitary Gland (58) (4) (57) (5) (58) (7)
Angiectasis 2 (3%) 6 (11%) 1 (2%)
Cyst 1 (2%)
Pars Distalis, Hyperplasia 7 (12%) 10 (18%) 11 (19%)
Thyroid Gland (58) (5) (60) (5) (58) (7)
Inflammation 1 (2%)
Artery, Inflammation 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicle, Atrophy 1 (2%)
Follicular Cell, Hyperplasia 20 (34%) 28 (47%) 37 (64%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (4) (1) (1)
Thoracic, Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (55) (5) (59) (5) (51) (5)
Atrophy 1 (2%) 8 (16%)
Ectasia 2 (4%) 1 (20%) 1 (2%) 1 (20%)
Inflammation 2 (3%)
Ovary (58) (4) (58) (5) (58) (7)
Abscess 1 (2%) 1 (2%)
Cyst 6 (10%) 8 (14%) 11 (19%)
Hemorrhage 1 (2%)
Periovarian Tissue, Cyst 1 (2%)
Uterus (58) (5) (60) (5) (58) (8)
Abscess 1 (2%) 1 (2%)
Angiectasis 1 (2%)
Cyst 5 (9%) 3 (5%) 3 (5%)
Cyst, Multiple 2 (3%)
Inflammation 1 (2%) 3 (5%)
Endometrium, Hyperplasia 14 (24%) 3 (60%) 19 (32%) 2 (40%) 19 (33%) 3 (38%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (57) (5) (60) (5) (57) (7)
Inflammation 1 (2%)
Erythroid Cell, Hyperplasia 3 (5%) 1 (2%)
Myeloid Cell, Atrophy 1 (2%)
Myeloid Cell, Hyperplasia 7 (12%) 7 (12%) 5 (9%)
Lymph Node (9) (12) (1) (11)
Pigmentation 1 (100%)
Iliac, Hyperplasia, Lymphoid 1 (8%) 2 (18%)
Inguinal, Hyperplasia, Lymphoid 1 (11%)
Inguinal, Inflammation 1 (11%)
Pancreatic, Hyperplasia 1 (9%)
Pancreatic, Inflammation 1 (11%) 1 (8%) 1 (9%)
Renal, Hyperplasia, Lymphoid 2 (17%) 3 (27%)
Renal, Inflammation 1 (8%)
Renal, Inflammation, Granulomatous 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lymph Node, Bronchial (50) (10) (57) (9) (58) (11)
Hyperplasia, Lymphoid 10 (20%) 46 (81%) 6 (67%) 51 (88%) 6 (55%)
Hyperplasia, Macrophage 44 (77%) 6 (67%) 47 (81%) 6 (55%)
Inflammation 1 (2%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Lymph Node, Mandibular (57) (7) (59) (7) (58) (10)
Hyperplasia 1 (10%)
Hyperplasia, Lymphoid 18 (32%) 4 (57%) 7 (12%) 2 (29%) 4 (7%) 3 (30%)
Hyperplasia, Plasma Cell 2 (4%) 1 (2%)
Inflammation 1 (2%)
Lymph Node, Mesenteric (55) (5) (54) (5) (55) (7)
Ectasia 1 (2%)
Hyperplasia, Lymphoid 4 (7%) 4 (7%) 6 (11%) 1 (14%)
Inflammation 3 (5%) 1 (2%) 2 (4%)
Lymph Node, Mediastinal (15) (28) (29) (3)
Hyperplasia, Lymphoid 1 (7%) 4 (14%) 1 (33%)
Inflammation 1 (3%)
Spleen (58) (5) (60) (5) (58) (7)
Atrophy 1 (2%) 1 (14%)
Hematopoietic Cell Proliferation 14 (24%) 2 (40%) 15 (25%) 8 (14%) 1 (14%)
Hyperplasia, Lymphoid 17 (29%) 27 (45%) 19 (33%)
Inflammation 1 (2%)
Lymphoid Follicle, Atrophy 2 (3%)
Red Pulp, Atrophy 1 (2%) 1 (2%)
Thymus (58) (5) (57) (5) (53) (6)
Degeneration 8 (14%) 5 (9%) 7 (13%) 1 (17%)
Hyperplasia 2 (3%)
Hyperplasia, Lymphoid 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (57) (5) (59) (5) (58) (7)
Hyperplasia 8 (14%) 11 (19%) 7 (12%)
Hyperplasia, Cystic 1 (2%)
Inflammation 1 (2%)
Skin (58) (5) (60) (5) (58) (7)
Fibrosis 1 (2%)
Hemorrhage 1 (2%)
Inflammation 3 (5%) 1 (14%)
Pinna, Cyst Epithelial Inclusion 1 (2%)
Pinna, Hyperkeratosis 1 (2%)
Pinna, Inflammation 2 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (57) (5) (60) (5) (57) (7)
Hyperostosis 1 (2%) 1 (2%)
Inflammation 1 (2%) 1 (2%)
Femur, Hyperostosis 10 (18%) 9 (15%) 10 (18%)
Maxilla, Hyperostosis 1 (2%)
Tibia, Fracture 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (58) (5) (60) (5) (58) (7)
Thalamus, Degeneration, Focal 1 (14%)
Spinal Cord (1) (1)
Abscess 1 (100%)
Degeneration 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (54) (4) (55) (4) (51) (6)
Inflammation 1 (2%)
Inflammation, Chronic 1 (25%)
Epithelium, Hyperplasia 1 (2%)
Lung (58) (10) (59) (10) (58) (12)
Bronchiectasis 1 (2%)
Fibrosis 7 (12%) 17 (29%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 46 (78%) 6 (60%) 56 (97%) 12 (100%)
Alveolar Epithelium, Hyperplasia 3 (5%) 53 (90%) 2 (20%) 57 (98%) 6 (50%)
Alveolus, Hyperplasia, Macrophage 5 (9%) 1 (10%) 57 (97%) 10 (100%) 58 (100%) 12 (100%)
Alveolus, Proteinosis 54 (92%) 9 (90%) 58 (100%) 11 (92%)
Bronchus, Hyperplasia, Lymphoid 34 (59%) 4 (40%) 26 (44%) 4 (40%) 34 (59%) 4 (33%)
Interstitium, Infiltration Cellular 19 (33%) 2 (20%) 53 (90%) 10 (100%) 57 (98%) 10 (83%)
Interstitium, Inflammation 1 (2%)
Nose (58) (10) (59) (10) (58) (12)
Inflammation, Acute 11 (19%) 13 (22%) 1 (8%)
Olfactory Epithelium, Atrophy 1 (2%) 11 (19%) 41 (71%) 1 (8%)
Olfactory Epithelium, Degeneration 26 (45%) 5 (50%) 3 (5%) 12 (21%)
Respiratory Epithelium, Degeneration 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (2) (1) (1) (2)
Inflammation 1 (50%) 1 (100%)
External Ear, Inflammation 1 (50%)
External Ear, Ulcer 1 (100%)
Eye (2)
Cataract 1 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (58) (10) (60) (10) (58) (12)
Hydronephrosis 1 (2%) 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Lymphocyte 9 (16%) 12 (20%) 1 (2%)
Inflammation 1 (2%)
Metaplasia, Osseous 1 (2%)
Nephropathy 5 (9%) 2 (3%) 1 (2%) 1 (8%)
Glomerulus, Inflammation 1 (8%)
Pelvis, Inflammation 1 (2%)
Renal Tubule, Pigmentation, Hemosiderin 1 (2%)
Urinary Bladder (56) (5) (55) (5) (57) (7)
Infiltration Cellular, Lymphocyte 1 (2%) 3 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 60 20 60 20 60 20
Scheduled Sacrifice 1 18 2 18 2 18
Early Deaths
Moribund Sacrifice 27 25 1 25 1
Natural Death 6 2 8 1 8 1
Survivors
Terminal Sacrifice 26 25 25
Animals Examined Microscopically 59 12 59 11 58 12
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (56) (6) (50) (5) (53) (5)
Epithelium, Hyperplasia 1 (2%)
Intestine Large, Cecum (56) (6) (54) (5) (54) (6)
Hyperplasia, Focal, Lymphoid 1 (2%) 1 (20%)
Lymphoid Tissue, Hyperplasia 1 (2%)
Lymphoid Tissue, Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Intestine Small, Ileum (55) (5) (51) (5) (54) (6)
Peyer's Patch, Hyperplasia, Lymphoid 3 (6%)
Liver (59) (7) (58) (6) (57) (7)
Angiectasis 1 (2%) 1 (14%) 3 (5%) 1 (2%)
Atrophy 1 (14%) 1 (2%) 2 (4%)
Basophilic Focus 2 (3%) 1 (2%) 1 (2%) 1 (14%)
Degeneration 1 (2%) 1 (17%)
Eosinophilic Focus 2 (3%) 2 (3%)
Hepatodiaphragmatic Nodule 2 (3%)
Infarct 2 (3%) 2 (3%) 2 (4%)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation 2 (3%)
Mixed Cell Focus 1 (2%) 1 (2%) 1 (14%)
Necrosis 7 (12%) 9 (16%) 5 (9%) 1 (14%)
Pigmentation, Hemosiderin 1 (2%) 1 (2%)
Regeneration 1 (2%)
Bile Duct, Hyperplasia 1 (2%)
Sinusoid, Cyst 1 (2%)
Pancreas (59) (7) (58) (6) (56) (7)
Infiltration Cellular, Lymphocyte 1 (2%)
Acinus, Atrophy 1 (2%) 1 (2%)
Acinus, Hyperplasia 1 (2%)
Stomach, Forestomach (59) (5) (58) (6) (55) (7)
Hyperplasia, Focal 1 (17%)
Inflammation 1 (2%)
Stomach, Glandular (59) (7) (58) (6) (55) (7)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Degeneration 1 (2%)
Hyperplasia, Focal 1 (17%)
Inflammation 1 (2%) 2 (3%)
Tooth (4) (1) (4)
Developmental Malformation 1 (25%) 2 (50%)
Inflammation 3 (75%) 1 (100%) 1 (25%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (59) (7) (58) (6) (58) (7)
Angiectasis 1 (2%)
Cardiomyopathy 1 (2%) 2 (3%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (59) (7) (58) (6) (56) (7)
Cyst 1 (2%)
Degeneration 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Focal 1 (2%) 2 (3%) 4 (7%)
Hypertrophy 1 (14%)
Hypertrophy, Focal 1 (2%)
Necrosis 1 (2%)
Islets, Pancreatic (59) (7) (58) (6) (56) (7)
Hyperplasia 1 (2%)
Pituitary Gland (56) (7) (57) (6) (53) (7)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (59) (7) (58) (6) (57) (7)
Follicular Cell, Hyperplasia 27 (46%) 25 (43%) 24 (42%) 1 (14%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Penis (12) (9) (8)
Concretion 4 (33%) 2 (22%) 1 (13%)
Inflammation 5 (42%) 6 (67%) 6 (75%)
Preputial Gland (59) (7) (58) (5) (58) (7)
Atrophy 3 (5%) 1 (2%) 1 (2%)
Ectasia 27 (46%) 5 (71%) 31 (53%) 5 (100%) 41 (71%) 4 (57%)
Hyperplasia 2 (3%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic 24 (41%) 1 (14%) 15 (26%) 7 (12%) 1 (14%)
Prostate (59) (7) (58) (6) (57) (7)
Inflammation 1 (2%) 2 (4%)
Seminal Vesicle (59) (7) (58) (6) (57) (7)
Hyperplasia 2 (3%)
Testes (59) (7) (58) (6) (57) (7)
Atrophy 1 (2%) 2 (4%)
Germinal Epithelium, Atrophy 2 (3%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (7) (58) (6) (57) (7)
Thrombosis 1 (2%)
Erythroid Cell, Hyperplasia 2 (3%) 3 (5%) 1 (2%)
Myeloid Cell, Hyperplasia 23 (39%) 11 (19%) 14 (25%) 1 (14%)
Lymph Node (18) (1) (11) (2) (10) (1)
Iliac, Hyperplasia, Lymphoid 3 (17%) 3 (30%)
Iliac, Hyperplasia, Plasma Cell 7 (39%) 1 (9%) 3 (30%)
Iliac, Inflammation 1 (6%) 1 (9%)
Iliac, Pigmentation 2 (11%) 1 (9%) 1 (10%)
Inguinal, Hyperplasia, Lymphoid 6 (33%) 5 (45%) 1 (50%) 6 (60%)
Inguinal, Hyperplasia, Plasma Cell 2 (11%) 3 (27%)
Inguinal, Inflammation 1 (9%)
Inguinal, Pigmentation 1 (6%) 1 (100%)
Lumbar, Hyperplasia, Lymphoid 1 (100%) 1 (50%)
Lumbar, Hyperplasia, Plasma Cell 1 (6%)
Lumbar, Pigmentation 1 (6%) 1 (100%) 1 (9%) 1 (50%)
Pancreatic, Hyperplasia, Lymphoid 1 (9%)
Renal, Hyperplasia, Lymphoid 1 (6%)
Renal, Hyperplasia, Plasma Cell 1 (6%)
Lymph Node, Bronchial (39) (8) (53) (7) (53) (11)
Hyperplasia, Lymphoid 4 (10%) 40 (75%) 5 (71%) 49 (92%) 8 (73%)
Hyperplasia, Macrophage 1 (3%) 47 (89%) 5 (71%) 49 (92%) 10 (91%)
Hyperplasia, Plasma Cell 1 (3%)
Lymph Node, Mandibular (51) (3) (51) (4) (55) (6)
Hyperplasia, Lymphoid 3 (6%) 1 (2%) 1 (17%)
Hyperplasia, Plasma Cell 1 (2%)
Lymph Node, Mesenteric (56) (7) (56) (6) (53) (7)
Hemorrhage, Chronic 1 (14%)
Hyperplasia, Lymphoid 2 (4%) 1 (14%) 5 (9%) 6 (11%)
Hyperplasia, Macrophage 1 (2%)
Inflammation 3 (5%) 1 (2%)
Lymph Node, Mediastinal (12) (3) (18) (3) (17) (5)
Hyperplasia 1 (33%)
Hyperplasia, Lymphoid 2 (17%) 1 (6%) 1 (6%)
Hyperplasia, Macrophage 1 (8%) 1 (6%) 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Plasma Cell 1 (6%)
Spleen (59) (7) (57) (6) (55) (7)
Atrophy 1 (14%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 8 (14%) 11 (19%) 1 (17%) 5 (9%)
Hyperplasia, Lymphoid 16 (27%) 8 (14%) 7 (13%) 1 (14%)
Inflammation 1 (2%)
Thymus (46) (7) (50) (5) (39) (7)
Atrophy 1 (2%)
Degeneration 11 (24%) 1 (14%) 12 (24%) 1 (20%) 15 (38%) 1 (14%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (59) (7) (56) (6) (57) (7)
Alopecia 1 (2%) 1 (2%)
Fibrosis 1 (14%)
Inflammation 2 (3%) 2 (4%)
Necrosis 1 (14%)
Parakeratosis 1 (2%)
Ulcer 1 (17%)
Pinna, Hyperkeratosis 1 (2%)
Prepuce, Hyperkeratosis 1 (2%)
Prepuce, Inflammation 16 (27%) 9 (16%) 13 (23%)
Subcutaneous Tissue, Abscess 1 (14%)
Tail, Hyperkeratosis 1 (2%)
Tail, Inflammation 1 (2%) 1 (2%) 1 (2%)
Tail, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (59) (7) (58) (6) (57) (7)
Developmental Malformation 1 (2%)
Hyperostosis 1 (2%)
Femur, Hyperostosis 1 (14%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (59) (7) (58) (6) (57) (7)
Cerebellum, White Matter, Degeneration, Focal 1 (2%)
Medulla, Degeneration, Focal 1 (14%) 1 (14%)
Medulla, Demyelination 1 (2%)
Spinal Cord (1) (1)
Degeneration, Secondary Wallerian 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (59) (12) (58) (11) (56) (12)
Autolysis 1 (2%)
Fibrosis 3 (5%) 15 (27%) 1 (8%)
Infiltration Cellular 1 (2%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic Active 1 (2%) 52 (90%) 8 (73%) 52 (93%) 11 (92%)
Alveolar Epithelium, Hyperplasia 3 (5%) 53 (91%) 4 (36%) 54 (96%) 5 (42%)
Alveolar Epithelium, Metaplasia, Squamous 1 (2%)
Alveolus, Hyperplasia 1 (2%)
Alveolus, Hyperplasia, Macrophage 6 (10%) 57 (98%) 10 (91%) 56 (100%) 12 (100%)
Alveolus, Proteinosis 57 (98%) 10 (91%) 56 (100%) 11 (92%)
Bronchus, Hyperplasia, Lymphoid 21 (36%) 3 (25%) 29 (50%) 1 (9%) 14 (25%) 2 (17%)
Interstitium, Infiltration Cellular 10 (17%) 54 (93%) 10 (91%) 53 (95%) 10 (83%)
Nose (59) (12) (58) (11) (57) (12)
Foreign Body 1 (2%)
Inflammation, Acute 3 (5%)
Olfactory Epithelium, Atrophy 1 (2%) 26 (45%) 5 (45%) 54 (95%) 9 (75%)
Olfactory Epithelium, Degeneration 3 (5%) 8 (14%) 6 (11%)
Olfactory Epithelium, Respiratory Epithelium,
Degeneration 1 (8%)
Trachea (59) (6) (58) (6) (56) (7)
Inflammation, Focal 3 (50%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (59) (12) (58) (11) (57) (12)
Hydronephrosis 8 (14%) 5 (9%) 1 (9%) 5 (9%)
Infiltration Cellular, Lymphocyte 7 (12%) 3 (5%) 2 (4%)
Inflammation 5 (8%) 1 (2%) 1 (2%) 1 (8%)
Nephropathy 9 (15%) 10 (17%) 6 (11%) 1 (8%)
Cortex, Atrophy 2 (3%)
Cortex, Fibrosis 1 (2%)
Pelvis, Inflammation 5 (8%) 1 (2%) 2 (4%)
Renal Tubule, Atrophy 1 (2%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Necrosis 1 (2%)
Ureter (2)
Inflammation 2 (100%)
Urethra (6) (2) (7) (1) (11) (1)
Calculus Micro Observation Only 2 (100%) 2 (18%) 1 (100%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05107-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 05/19/95
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 22:48:31
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0.0MG/M3 0.0MG/M3 0.6MG/M3 0.6MG/M3 1.2MG/M3 1.2MG/M3
LUNG TOX LUNG TOX LUNG TOX
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Concretion 5 (83%) 6 (86%) 1 (100%) 8 (73%)
Inflammation 1 (17%) 1 (9%)
Urinary Bladder (59) (7) (58) (7) (56) (7)
Calculus Gross Observation 1 (2%) 2 (3%) 1 (14%)
Calculus Micro Observation Only 1 (2%) 1 (14%) 1 (2%) 1 (14%) 2 (4%)
Crystals 1 (2%)
Hyperplasia 1 (2%)
Inflammation 11 (19%) 2 (3%) 3 (5%) 1 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
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