National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1867

TDMS Study 05107-06 Pathology Tables

NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00




       Facility:  Lovelace Inhalation Toxicology Research Institute

       Chemical CAS #:  12035722

       Lock Date:  10/14/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 6| 7| 6|             
                             DAY ON TEST   | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 1| 8| 3| 9|             
                                           | 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 7| 4| 3| 6| 9| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                      3                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +|             
      Atrophy                              |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +|             
      Atrophy                              |                            3                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +|             
      Atrophy                              |                            3                                             |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |          2                                                               |             
      Cyst                                 |                                                                          |             
      Degeneration                         |                                                                          |             
      Fibrosis                             |                                                                          |             
      Infarct                              |                                                                   4      |             
      Infiltration Cellular, Lymphocyte    |             3                                2                           |             
      Inflammation                         |                            4                                             |             
      Necrosis                             |          3                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                                      |             
      Necrosis                             |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                            3                                             |             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
      Acinus, Atrophy                      |                                                       4                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                                |             
      Inflammation                         |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation                         |                            3                                             |             
      Artery, Inflammation                 |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 6| 7| 6|             
                             DAY ON TEST   | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 1| 8| 3| 9|             
                                           | 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 7| 4| 3| 6| 9| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                             X            |             
      Pars Distalis, Hyperplasia           |                2  2           4                          4        2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Artery, Inflammation                 |                                                                          |             
      Follicle, Atrophy                    |                                                                          |             
      Follicular Cell, Hyperplasia         |    1  2     1     1  1     4     2                       2  2     1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  M  +  +  +  M|             
      Ectasia                              |                                                                2         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Abscess                              |                            3                                             |             
      Angiectasis                          |                                                             4            |             
      Cyst                                 | X              X                                X                       X|             
      Endometrium, Hyperplasia             |       2     2                    4  2        2                       2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation                         |                            3                                             |             
      Myeloid Cell, Hyperplasia            | 3                 3                             3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                            +                                +  +         |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Inflammation               |                            4                                             |             
      Pancreatic, Inflammation             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  I  +|             
      Hyperplasia, Lymphoid                | 1        2  1     3     2     1  2                                       |             
      Inflammation                         |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 4     2  3  3  3              4                          2  2           4|             
      Hyperplasia, Plasma Cell             |                   3                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 6| 7| 6|             
                             DAY ON TEST   | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 1| 8| 3| 9|             
                                           | 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 7| 4| 3| 6| 9| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia, Lymphoid                |                               2                          2               |             
      Inflammation                         |                            4                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  +  M  +  M  M  M  M  I  M  M  +  M  M  +     +  I  +  +  M  M  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 4        3        3  3                 3  4  2        2     4  2        3|             
      Hyperplasia, Lymphoid                |    3  3     4           2     3  2  2                    3               |             
      Inflammation                         |                            4                                             |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Degeneration                         |                                           3                    3  2      |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  M  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |       2                       2  2                    3                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation                         |                                                                2        4|             
      Pinna, Inflammation                  |                            4                    4                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Inflammation                         |          2                                                               |             
      Femur, Hyperostosis                  |                               X                                      X  X|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
      Degeneration                         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +     M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Hyperplasia, Macrophage    |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 6| 7| 6|             
                             DAY ON TEST   | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 1| 8| 3| 9|             
                                           | 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 7| 4| 3| 6| 9| 3| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|             
                                           | 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Bronchus, Hyperplasia, Lymphoid      | 1  2  1  2  2  2  1  2  2        2  2           2     2  2        2  2  1|             
      Interstitium, Infiltration Cellular  |       1           1     1     1        2  2  1              2            |             
      Interstitium, Inflammation           |                            2                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration   |       1        1     1     1        1  1        1     1  1        1  1   |             
      Respiratory Epithelium, Degeneration |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                        +                                 |             
      Inflammation                         |                                        3                                 |             
      External Ear, Inflammation           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                         3|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|             
      Infarct                              |          3                                                               |             
      Infiltration Cellular, Lymphocyte    |    2     2                    2              2  2                        |             
      Inflammation                         |                            4                                             |             
      Nephropathy                          |                         1              2                    3            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  I  +|             
      Infiltration Cellular, Lymphocyte    |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3|             
                                           | 9| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   4      |             
      Cyst                                 |                                                                          |             
      Degeneration                         |                            4                                             |             
      Fibrosis                             |                                                 2                        |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                   1           2     1                                    |             
      Necrosis                             |                               3                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Necrosis                             |                                                 4                        |             
      Artery, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |             4                                                            |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Squamous                |                                  2                 1                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation                         |                      2                                                   |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +                                                               |             
      Inflammation                         |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Artery, Inflammation                 |                                                                          |             
      Atrium, Thrombosis                   | X           X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3|             
                                           | 9| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             3            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |             2  2                                                         |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation                 |                                                                          |             
      Follicle, Atrophy                    |                                                                          |             
      Follicular Cell, Hyperplasia         | 2     1                             2  3        1        1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                                                      2   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                             X     X        X                       X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Endometrium, Hyperplasia             |                      2  2     2  2     2                 3               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +                    +     +                                    |             
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |             
      Inguinal, Inflammation               |                                                                          |             
      Pancreatic, Inflammation             |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  I  I  +  +  +  +  M  +  +  +  +  +  I  +  +  +  +  +  I  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   2                                            3         |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia, Lymphoid                |                      3  2     2                 3              3        4|             
      Hyperplasia, Plasma Cell             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3|             
                                           | 9| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Ectasia                              |                      4                                                   |             
      Hyperplasia, Lymphoid                |                      2                                                   |             
      Inflammation                         |                               4                    3                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  I  M  M  M  M  M  M  +  M  M  M  +  +  M  M  M  +  +  M  M  +  M  M  M|             
      Hyperplasia, Lymphoid                |                                                                2         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    2                    2     4                                          |             
      Hyperplasia, Lymphoid                |    2                 2           2              2                       2|             
      Inflammation                         |                                                                          |             
      Lymphoid Follicle, Atrophy           |             3                             2                              |             
      Red Pulp, Atrophy                    |                            2                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |             3              4              4                 3        3   |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |             2                                                            |             
      Hyperplasia                          |                2                    3                       2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   3      |             
      Inflammation                         |                                                             4            |             
      Pinna, Inflammation                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |             X                                                            |             
      Inflammation                         |                                                                          |             
      Femur, Hyperostosis                  |    X                             X     X                 X               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Degeneration                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             2                                                            |             
      Alveolar Epithelium, Hyperplasia     |                            4                 2           1               |             
      Alveolus, Hyperplasia, Macrophage    |          1  4                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7|             
                             DAY ON TEST   | 7| 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3|             
                                           | 9| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.0MG/M3                               | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
                                           | 4| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Bronchus, Hyperplasia, Lymphoid      |    1              1  2     3     2     1  1                 1  1  1     1|             
      Interstitium, Infiltration Cellular  |          1  1  1        1     1                 1  1     1               |             
      Interstitium, Inflammation           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                                        1                                 |             
      Olfactory Epithelium, Degeneration   | 1  1  1  2        1                 1  1        1     1        1        1|             
      Respiratory Epithelium, Degeneration |                                                                   3      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                +         |             
      Inflammation                         |                                                                          |             
      External Ear, Inflammation           |                                                                3         |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                            2                       2  1                 2|             
      Inflammation                         |                                                                          |             
      Nephropathy                          |          2                             1                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 3| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 0| 3| 8| 7| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 0| 3| 5| 7| 6| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0MG/M3                               | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 9| 1| 2| 3| 4| 5| 6| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  I  +     +  +  +                                             |  53        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  M  +  M  +     +  M  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +                                             |  54        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +  +                                             |  53        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +  +                                             |  54        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +  +                                             |  54        |
      Atrophy                              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +  +                                             |  58        |
      Angiectasis                          |          2                                                               |      3  2.7|
      Cyst                                 |          X                                                               |      1     |
      Degeneration                         |                                                                          |      1  4.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Infarct                              |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  2.5|
      Inflammation                         |                                                                          |      4  2.0|
      Necrosis                             |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   3        |
      Necrosis                             |                                                                          |      1  4.0|
      Artery, Inflammation                 |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +     +  +  +                                             |  58        |
      Atrophy, Focal                       |                                                                          |      2  3.5|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                            2                                             |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +  +                                             |  57        |
      Hyperplasia, Squamous                |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +  +                                             |  57        |
      Inflammation                         |          3                                                               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Inflammation                         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 3| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 0| 3| 8| 7| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 0| 3| 5| 7| 6| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0MG/M3                               | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 9| 1| 2| 3| 4| 5| 6| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +  +                                             |  58        |
      Inflammation                         |                                                                          |      1  3.0|
      Artery, Inflammation                 |                3                                                         |      1  3.0|
      Atrium, Thrombosis                   |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +     +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +     +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  +     +  +  M                                             |  52        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      2  2.0|
      Cyst                                 |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |          2           3                                                   |      7  2.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +     +  +  +                                             |  58        |
      Artery, Inflammation                 |                2                                                         |      1  2.0|
      Follicle, Atrophy                    |                         2                                                |      1  2.0|
      Follicular Cell, Hyperplasia         |    3        3           1                                                |     20  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +     +  +  +                                             |  55        |
      Ectasia                              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +     +  +  +                                             |  58        |
      Cyst                                 |                      X                                                   |      6     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +  +  +                                             |  58        |
      Abscess                              |                                                                          |      1  3.0|
      Angiectasis                          |                                                                          |      1  4.0|
      Cyst                                 | X                                                                        |      5     |
      Endometrium, Hyperplasia             |    2                 2                                                   |     14  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +  +                                             |  57        |
      Inflammation                         |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            | 3           2              2                                             |      7  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 3| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 0| 3| 8| 7| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 0| 3| 5| 7| 6| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0MG/M3                               | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 9| 1| 2| 3| 4| 5| 6| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +           +                                             |   9        |
      Inguinal, Hyperplasia, Lymphoid      |                3                                                         |      1  3.0|
      Inguinal, Inflammation               |                                                                          |      1  4.0|
      Pancreatic, Inflammation             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  I  +  +     +  +  +                                             |  50        |
      Hyperplasia, Lymphoid                |                            2                                             |     10  1.9|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +  +                                             |  57        |
      Hyperplasia, Lymphoid                | 4  2           4                                                         |     18  3.0|
      Hyperplasia, Plasma Cell             |       3                                                                  |      2  3.0|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +  +                                             |  55        |
      Ectasia                              |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |       2                                                                  |      4  2.0|
      Inflammation                         |                                                                          |      3  3.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  M  M  M     M  M  M                                             |  15        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +  +                                             |  58        |
      Hematopoietic Cell Proliferation     |                                                                          |     14  2.9|
      Hyperplasia, Lymphoid                | 3  1        2           2                                                |     17  2.4|
      Inflammation                         |                                                                          |      1  4.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  2.5|
      Red Pulp, Atrophy                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     +  +  +                                             |  58        |
      Degeneration                         |                                                                          |      8  3.1|
      Hyperplasia                          |    3  2                                                                  |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +     +  +  +                                             |  57        |
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
      Hyperplasia                          |       2                                                                  |      8  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  +  +                                             |  58        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      3  3.3|
      Pinna, Inflammation                  |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +  +                                             |  57        |
      Hyperostosis                         |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 7| 3| 4| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 0| 3| 8| 7| 3| 3| 3|                                            |            |
                                           | 3| 3| 3| 0| 3| 5| 7| 6| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    0.0MG/M3                               | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 9| 1| 2| 3| 4| 5| 6| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
      Inflammation                         |                                                                          |      1  2.0|
      Femur, Hyperostosis                  |       X              X  X                                                |     10     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Degeneration                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +     +  +  M                                             |  54        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +  +  +                                             |  58        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.3|
      Alveolus, Hyperplasia, Macrophage    |    1                    1                                                |      5  1.8|
      Bronchus, Hyperplasia, Lymphoid      | 1     1     1  1        1  1                                             |     34  1.5|
      Interstitium, Infiltration Cellular  |    1                 1     1                                             |     19  1.2|
      Interstitium, Inflammation           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +     +  +  +                                             |  58        |
      Olfactory Epithelium, Atrophy        |                                                                          |      1  1.0|
      Olfactory Epithelium, Degeneration   | 1  1  1              1                                                   |     26  1.0|
      Respiratory Epithelium, Degeneration |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +  +  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
      Inflammation                         |                                                                          |      1  3.0|
      External Ear, Inflammation           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                                |   2        |
      Cataract                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +  +  +                                             |  58        |
      Infarct                              |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      9  1.9|
      Inflammation                         |                                                                          |      1  4.0|
      Nephropathy                          |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +  +                                             |  56        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 1| 1| 1| 1| 1| 4| 4| 4| 1| 1| 1| 4| 4| 1| 4| 4| 1| 0| 4|              |            |
                             DAY ON TEST   | 6| 9| 9| 9| 9| 9| 7| 7| 7| 9| 9| 9| 7| 7| 9| 7| 7| 9| 6| 7|              |            |
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    0.0MG/M3                               | 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5|              |      L     |
    LUNG TOX                               | 2| 0| 2| 4| 5| 7| 1| 3| 2| 3| 4| 5| 6| 3| 9| 0| 3| 5| 0| 7|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                      M  +           +  +        +                        |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                      +  +           +  +        +                        |   5        |
      Hyperplasia, Lymphoid                |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                      +  +           +  +        +                        |   5        |
      Hyperplasia, Lymphoid                |                      3                                                   |      1  3.0|
      Hyperplasia                          |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                      +  +           +  +        +                        |   5        |
      Basophilic Focus                     |                                        X                                 |      1     |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                      +  +           +  +        +                        |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                      +  +           +  +        +                        |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                      +  M           +  +        I                        |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                      +  +           +  +        M                        |   4        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                      +  +           +  +        +                        |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                      +  +           +  +        +                        |   5        |
      Ectasia                              |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |                      +  +           +  M        +                        |   4        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                      +  +           +  +        +                        |   5        |
      Endometrium, Hyperplasia             |                      2  2                       3                        |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 1| 1| 1| 1| 1| 4| 4| 4| 1| 1| 1| 4| 4| 1| 4| 4| 1| 0| 4|              |            |
                             DAY ON TEST   | 6| 9| 9| 9| 9| 9| 7| 7| 7| 9| 9| 9| 7| 7| 9| 7| 7| 9| 6| 7|              |            |
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    0.0MG/M3                               | 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5|              |      L     |
    LUNG TOX                               | 2| 0| 2| 4| 5| 7| 1| 3| 2| 3| 4| 5| 6| 3| 9| 0| 3| 5| 0| 7|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +  +           +  +     +  +  +  +        +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |       +              M  +     +  +  +  +        +                        |   7        |
      Hyperplasia, Lymphoid                |       1                       2     3           2                        |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       M  M           M  M     M  M  M  M        M  M                     |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                      +  +           +  +        +                        |   5        |
      Hematopoietic Cell Proliferation     |                      1  1                                                |      2  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                      +  +           +  +        +                        |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                      +  +           +  +        +                        |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                      +  +           +  +        +                        |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                      +  +           +  +        +                        |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                      +  +           +  +        +                        |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                      +  +           M  +        +                        |   4        |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +           +  +     +  +  +  +        +  +                     |  10        |
      Alveolus, Hyperplasia, Macrophage    |                                  1                                       |      1  1.0|
      Bronchus, Hyperplasia, Lymphoid      |                         1           2  2        1                        |      4  1.5|
      Interstitium, Infiltration Cellular  |          1                                      1                        |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +           +  +     +  +  +  +        +  +                     |  10        |
      Olfactory Epithelium, Degeneration   |       1  1                    1  1              2                        |      5  1.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                      +  +           +  +        +                        |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                     +                                    |   1        |
      External Ear, Ulcer                  |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +           +  +     +  +  +  +        +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                      +  +           +  +        +                        |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|             
                                           | 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  M  M  +  +  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |       3                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation                         |                                              4                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                         3                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   4      |             
      Atrophy                              |             2                 3                                          |             
      Basophilic Focus                     |                   X                                                      |             
      Degeneration                         |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                                                                          |             
      Mixed Cell Focus                     |                                                    X                     |             
      Necrosis                             |       1  2                                                               |             
      Pigmentation, Hemosiderin            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +        +        +                                          |             
      Inflammation                         |             4                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                             X            |             
      Infiltration Cellular, Lymphocyte    |                                                 2     2                  |             
      Inflammation                         |             4                                                            |             
      Acinus, Atrophy                      |                                                             4            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |             2              1                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                        |             
      Developmental Malformation           | X                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|             
                                           | 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                        2                                 |             
      Atrophy                              |                                                                          |             
      Hyperplasia, Focal                   |             3                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  3        3                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                            3                                         3   |             
      Pars Distalis, Hyperplasia           |             2     2     4                                               3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 2     1  2  1           1           2           1  1  2  1  1  1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          +     +                       +                                 |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        3                                 |             
      Ectasia                              |                                                                   1      |             
      Inflammation                         |                                                       1                  |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |             X  X        X              X                             X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |                   X           X                                          |             
      Cyst, Multiple                       |                                                                          |             
      Inflammation                         |                                                                          |             
      Endometrium, Hyperplasia             | 2  2                    2           3              2     3  3  3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                              3                           |             
      Myeloid Cell, Atrophy                |                                                                          |             
      Myeloid Cell, Hyperplasia            |          2           3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +              +                                   +      |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Pancreatic, Inflammation             |             3                                                            |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Inflammation, Granulomatous   |                                                                          |             
      Renal, Inflammation                  |             4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1  3  2           1  3  2  3     4  3     2  1  3  3  3  4  2  1     2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|             
                                           | 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Macrophage              | 1  2  2           1  2  2  2     1  1     2  2  2  1  1  1  1  3     2  1|             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation                         |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       3                 3|             
      Inflammation                         |             4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  +  M  +  +  M  +  I  +  M  M  M  +  M  +  M  I  +  +  +  +  I  +|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3                                          |             
      Hematopoietic Cell Proliferation     |       3  2  3                    3     3     2                 2         |             
      Hyperplasia, Lymphoid                |                      2  2  2                    3  3  2  2  3        2  4|             
      Red Pulp, Atrophy                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |             3                 3           3                              |             
      Hyperplasia, Lymphoid                |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                 2                       3|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |                                                             X        X   |             
      Tibia, Fracture                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                   +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                            1                                             |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchiectasis                       |                            3                                             |             
      Fibrosis                             | 1                          1        1                                1   |             
      Inflammation, Acute                  |             2                                                            |             
      Inflammation, Chronic Active         | 1  2  1     1     2     2  3  1     2           2  1  2  3  1  2  1  2  2|             
      Alveolar Epithelium, Hyperplasia     | 2  2  2  2  2  1  2     2  1  1  1  2  1  2  1  3  2  2  3  2  2  1  2  2|             
      Alveolus, Hyperplasia, Macrophage    | 3  3  2  2  2  2  2  2  2  2  2  2  3  2  2  2  3  2  3  3  3  3  3  3  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|             
                                           | 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Proteinosis                | 3  3  3  2  2  3  1  2  2  4  1     4  2  2  4  3  3  3  2  3  4  2  3  4|             
      Bronchus, Hyperplasia, Lymphoid      | 2           2     3     2  1  1  2           1  1        4  1  1     2  3|             
      Interstitium, Infiltration Cellular  | 3  4  2  1  3     1  1  3  2  2  3  2  2  1  1  3  2  3  1  2  3     4  3|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 4                             1                                         1|             
      Olfactory Epithelium, Atrophy        |    1                                                              1      |             
      Olfactory Epithelium, Degeneration   |                                                          1              1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                3                                                         |             
      Infiltration Cellular, Lymphocyte    |       1                 2                                2  2            |             
      Nephropathy                          |                                        1                                 |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                     2                                2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|             
                                           | 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.6MG/M3                               | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |          4                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                      3              3                                    |             
      Basophilic Focus                     |                                                                          |             
      Degeneration                         |                                                                      2   |             
      Eosinophilic Focus                   |                                        X                                 |             
      Infarct                              |          4                                                        4      |             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
      Inflammation                         |                                        3                                1|             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                  3                                       |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                     |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                   1     1                       1                        |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|             
                                           | 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.6MG/M3                               | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                   3                                                      |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  I|             
      Angiectasis                          |                   3  4                                                   |             
      Pars Distalis, Hyperplasia           | 3        3              4                    3           3        3      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    1     2              2                    1  2     1  2     2  2  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |                                                                          |             
      Inflammation                         |                                              1                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                         4|             
      Cyst                                 |                                        X     X        X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |             4                                                            |             
      Cyst                                 |                      X                                                   |             
      Cyst, Multiple                       |                                                                      X   |             
      Inflammation                         |                1                                                         |             
      Endometrium, Hyperplasia             | 4  3  2  3     3                          2  2  4              3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                                       3                  |             
      Myeloid Cell, Atrophy                |                      3                                                   |             
      Myeloid Cell, Hyperplasia            |          3  3           3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +              +     +           +              +      |             
      Iliac, Hyperplasia, Lymphoid         |                                                                   4      |             
      Pancreatic, Inflammation             |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                        4                          4      |             
      Renal, Inflammation, Granulomatous   |                                                                          |             
      Renal, Inflammation                  |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M|             
      Hyperplasia, Lymphoid                | 3  1  2  3  2  1     2  3     2     2  2  3  2  2     2  2  1  1  2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|             
                                           | 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.6MG/M3                               | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Macrophage              | 1  1  1  1  1  1     1  1     2     1  3  2  2  2     1  2     1         |             
      Inflammation, Granulomatous          |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2        3  3                                   3        1               |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2        3                                                               |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  M  +  +  +  M  M  +  M  +  +  I  M  M  M  +  +  I  M  M  M  +  M|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |    4        3                 3                       3        3  2      |             
      Hyperplasia, Lymphoid                | 3     2  3              2  2           4  2  2  2        2        3     2|             
      Red Pulp, Atrophy                    |                      3                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Degeneration                         |                      4  2                                                |             
      Hyperplasia, Lymphoid                |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  3        3  2  2                       3        3               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femur, Hyperostosis                  |    X  X                       X              X  X                 X      |             
      Tibia, Fracture                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Inflammation                         |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Bronchiectasis                       |                                                                          |             
      Fibrosis                             |          1        1                       1                              |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 2  1  2  3  1  3  2  3  1     2     1  3  1  1  1     1  2     2  2  2   |             
      Alveolar Epithelium, Hyperplasia     | 2  2  2  2  2  2  2  2  2     2     1  2  2  2  2     2  2     2  2  2   |             
      Alveolus, Hyperplasia, Macrophage    | 3  3  3  3  2  4  4  2  3     3  1  2  4  3  3  3     2  3     3  4  2  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|             
                             DAY ON TEST   | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|             
                                           | 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|             
    0.6MG/M3                               | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|             
                                           | 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Proteinosis                | 1  2  4  3  3  4  2  4  3     3  1  4  2  4  2  3     3  3     3  2  2   |             
      Bronchus, Hyperplasia, Lymphoid      | 2  1  2  1  1                       1                 3           1  1   |             
      Interstitium, Infiltration Cellular  | 4  3  4  4  3  2  2  2  2     3     3  3  3  3  3     1  3     4  4  2  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 3  3           1  2     2           1           1                        |             
      Olfactory Epithelium, Atrophy        |    1  1              1           1        1  1     1  1                  |             
      Olfactory Epithelium, Degeneration   |    1                                                                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Infiltration Cellular, Lymphocyte    |    2  2  2              1                             2  1     1  3      |             
      Nephropathy                          |                               1                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3|                                            |            |
                                           | 4| 0| 3| 7| 3| 3| 3| 2| 6| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.6MG/M3                               | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  A  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  A  +  +                                             |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +                                             |  54        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +                                             |  53        |
      Inflammation                         |                2                                                         |      2  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  A  +  +                                             |  52        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  4.0|
      Atrophy                              |                                                                          |      4  2.8|
      Basophilic Focus                     |                                                                          |      1     |
      Degeneration                         |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Infarct                              |                                                                          |      2  4.0|
      Infiltration Cellular, Lymphocyte    |                            1                                             |      2  1.5|
      Inflammation                         |                2                                                         |      3  2.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                                                          |      3  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  M  +  +  +  A  +  +                                             |  56        |
      Cyst                                 |                                                                          |      1     |
      Infiltration Cellular, Lymphocyte    |                            1                                             |      3  1.7|
      Inflammation                         |                                                                          |      1  4.0|
      Acinus, Atrophy                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +                                             |  58        |
      Inflammation                         |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3|                                            |            |
                                           | 4| 0| 3| 7| 3| 3| 3| 2| 6| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.6MG/M3                               | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cardiomyopathy                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      1  2.0|
      Atrophy                              |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  M  +  +  +  A  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Angiectasis                          | 2                          2                                             |      6  2.8|
      Pars Distalis, Hyperplasia           |                                                                          |     10  3.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Follicular Cell, Hyperplasia         |    1     2  1     2                                                      |     28  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |       +                                                                  |   4        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  3.0|
      Ectasia                              |                                                                          |      1  1.0|
      Inflammation                         |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  A  +  +                                             |  58        |
      Abscess                              |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      8     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  4.0|
      Cyst                                 |                                                                          |      3     |
      Cyst, Multiple                       |       X                                                                  |      2     |
      Inflammation                         |                                                                          |      1  1.0|
      Endometrium, Hyperplasia             | 2                       2                                                |     19  2.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erythroid Cell, Hyperplasia          |    2                                                                     |      3  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3|                                            |            |
                                           | 4| 0| 3| 7| 3| 3| 3| 2| 6| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.6MG/M3                               | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Myeloid Cell, Atrophy                |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |             3  3                                                         |      7  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |  12        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  4.0|
      Pancreatic, Inflammation             |                                                                          |      1  3.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  4.0|
      Renal, Inflammation, Granulomatous   |                4                                                         |      1  4.0|
      Renal, Inflammation                  |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  +                                             |  57        |
      Hyperplasia, Lymphoid                | 1  2  3  1  1     4     1  3                                             |     46  2.2|
      Hyperplasia, Macrophage              | 1  1  1  1  2     2     2  1                                             |     44  1.5|
      Inflammation, Granulomatous          |                3                                                         |      1  3.0|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Lymphoid                |             2     3                                                      |      7  2.4|
      Hyperplasia, Plasma Cell             |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +  +  +  A  +  +                                             |  54        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.8|
      Inflammation                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  M  +  +  +  M  I  +                                             |  28        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |    3           2                                                         |     15  2.7|
      Hyperplasia, Lymphoid                | 2           2     3     2  3                                             |     27  2.4|
      Red Pulp, Atrophy                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  A  +  +                                             |  57        |
      Degeneration                         |                                                                          |      5  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  M  +  +                                             |  59        |
      Hyperplasia                          |             2     3                                                      |     11  2.5|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Femur, Hyperostosis                  |                         X                                                |      9     |
      Tibia, Fracture                      | X                                                                        |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 5| 7| 1| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3|                                            |            |
                                           | 4| 0| 3| 7| 3| 3| 3| 2| 6| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    0.6MG/M3                               | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 9| 0| 1| 2| 3| 4| 5| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  I  +  +  +  +  +                                             |  55        |
      Inflammation                         |                                                                          |      1  1.0|
      Epithelium, Hyperplasia              |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Bronchiectasis                       |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      7  1.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         | 2     1  1  1  2  1     2  2                                             |     46  1.7|
      Alveolar Epithelium, Hyperplasia     | 2  2  2  1  2  2  1     2  1                                             |     53  1.8|
      Alveolus, Hyperplasia, Macrophage    | 4  2  2  2  3  3  3  1  3  3                                             |     57  2.6|
      Alveolus, Proteinosis                | 4  3  3  2  2  2  4     3  3                                             |     54  2.8|
      Bronchus, Hyperplasia, Lymphoid      |    2  1        2                                                         |     26  1.7|
      Interstitium, Infiltration Cellular  | 3  2  3  3  3  3  3     2  3                                             |     53  2.6|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  A  +  +                                             |  59        |
      Inflammation, Acute                  | 1                                                                        |     11  1.8|
      Olfactory Epithelium, Atrophy        |    1                                                                     |     11  1.0|
      Olfactory Epithelium, Degeneration   |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |             +                                                            |   1        |
      Inflammation                         |             4                                                            |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hydronephrosis                       |                                                                          |      1  3.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |     12  1.8|
      Nephropathy                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +                                             |  55        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 1| 1| 4| 4| 4| 4| 1| 4| 1| 4| 1| 4| 1| 1| 1| 1| 1| 4| 4|              |            |
                             DAY ON TEST   | 7| 9| 9| 7| 7| 7| 7| 9| 7| 9| 7| 9| 7| 9| 9| 9| 9| 9| 7| 7|              |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|              |      A     |
    0.6MG/M3                               | 5| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1|              |      L     |
    LUNG TOX                               | 2| 3| 4| 9| 0| 5| 0| 9| 2| 6| 7| 8| 9| 0| 2| 4| 7| 0| 6| 7|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +           +  +  +           M                                          |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +           +  +  +           +                                          |   5        |
      Hyperplasia, Lymphoid                | 2              2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +           +  +  +           +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +           +  +  +           +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +           +  M  M           +                                          |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +           +  +  +           +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +           +  +  +           +                                          |   5        |
      Endometrium, Hyperplasia             |                   2           3                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                                     |   1        |
      Pigmentation                         |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 1| 1| 4| 4| 4| 4| 1| 4| 1| 4| 1| 4| 1| 1| 1| 1| 1| 4| 4|              |            |
                             DAY ON TEST   | 7| 9| 9| 7| 7| 7| 7| 9| 7| 9| 7| 9| 7| 9| 9| 9| 9| 9| 7| 7|              |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3|              |      A     |
    0.6MG/M3                               | 5| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1|              |      L     |
    LUNG TOX                               | 2| 3| 4| 9| 0| 5| 0| 9| 2| 6| 7| 8| 9| 0| 2| 4| 7| 0| 6| 7|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +        +  +  +  +        +              M  +  +                     |   9        |
      Hyperplasia, Lymphoid                | 3           2  4  2           2                    1                     |      6  2.3|
      Hyperplasia, Macrophage              | 2           1  1  1           1                    1                     |      6  1.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +           +  +  +  M        +                 +  +                     |   7        |
      Hyperplasia, Lymphoid                |                2                                   1                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M        M  M  M  M        M              M  M  I                     |            |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +           +  +  +           +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +           +  +  +           +                                          |   5        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +           +  +  +           +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +           +  +  +           +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +           +  +  +           +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +           +  +  +           M                                          |   4        |
      Inflammation, Chronic                |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +        +  +  +  +        +              +  +  +                     |  10        |
      Inflammation, Chronic Active         | 2           2     3           3              1     1                     |      6  2.0|
      Alveolar Epithelium, Hyperplasia     | 1                             1                                          |      2  1.0|
      Alveolus, Hyperplasia, Macrophage    | 1  1        2  2  1  1        2              1  1  1                     |     10  1.3|
      Alveolus, Proteinosis                | 3           1  2  4  1        4              1  1  1                     |      9  2.0|
      Bronchus, Hyperplasia, Lymphoid      | 2           2  1              3                                          |      4  2.0|
      Interstitium, Infiltration Cellular  | 1  1        3  3  2  2        2              1  2  1                     |     10  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +        +  +  +  +        +              +  +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +           +  +  +           +                                          |   5        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +        +  +  +  +        +              +  +  +                     |  10        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +           +  +  +           +                                          |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|             
                                           | 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  M  A  +  +  A  +  A  +  +  A  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  M  +  M  M  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  A  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  A  +  A  A  +  A  +  +  A  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  A  +  A  A  +  A  +  +  A  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  A  A  +  A  +  +  A  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   4                                                      |             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Degeneration                         |          3           3                                                   |             
      Eosinophilic Focus                   |                                                                X         |             
      Infarct                              |                                        4                                 |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                            3                                             |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                          +               |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Acinus, Atrophy                      |                                                          2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |          2                                                               |             
      Inflammation                         |                                                                   1      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |       1                       2                                   1      |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                                                                     |             
      Developmental Malformation           |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      3                                                   |             
      Atrophy                              |                                                                         4|             
      Degeneration                         |                                              2                           |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|             
                                           | 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  I  +  +  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Hyperplasia           |                               2        3                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                               1                                          |             
      Follicular Cell, Hyperplasia         | 3     1  1  2        1           2  1  1  3           1  2  3           1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Thoracic, Inflammation               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  A  M  +  +  +  +  +  +  +  +|             
      Atrophy                              |                   3                 3              3     3     2         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                         4|             
      Cyst                                 | X                                      X     3     X                     |             
      Hemorrhage                           |                                              2                           |             
      Periovarian Tissue, Cyst             |                            X                                             |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         2           X                                   X|             
      Inflammation                         |          2                                                               |             
      Endometrium, Hyperplasia             |    3     3     1              3  2              2     2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |                               3                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +                    +  +     +                                   +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Pancreatic, Hyperplasia              |                                                                          |             
      Pancreatic, Inflammation             |                                                                         4|             
      Renal, Hyperplasia, Lymphoid         |                               4                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2  2     2  2  1  1  4  1  2  3  2     2  1  3  3     3     4     1  3  4|             
      Hyperplasia, Macrophage              | 2  2     1  2  2  1  1  1  2  2  2     2  1     1     2  3  2     2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                               4                                         4|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|             
                                           | 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                               3  2                                       |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  +  I  M  M  +  +  M  +  +  +  +  M  +  M  +  I  M  +  M  M  M  +|             
      Hyperplasia, Lymphoid                |                                                                         4|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   2                                               2      |             
      Hyperplasia, Lymphoid                |             2        3        3           2  3              2           2|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Degeneration                         |          3        2        3                 3                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                               2                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                   2                                                      |             
      Pinna, Cyst Epithelial Inclusion     |       X                                                                  |             
      Pinna, Hyperkeratosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
      Inflammation                         |                                                                         3|             
      Femur, Hyperostosis                  |    X                                                              X      |             
      Maxilla, Hyperostosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                         +|             
      Abscess                              |                                                                         4|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | I  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |    1        2  2        1                       1     1     1            |             
      Inflammation, Chronic Active         | 1  2  2  3  2  2  2  2  2  1  3  2  2  2  2     3  1  2  1  3     1  1  2|             
      Alveolar Epithelium, Hyperplasia     | 2  3  3  2  2  3  2  2  1  2  1  2  3  1  1     2  2  2  2  2  2  3  2  3|             
      Alveolus, Hyperplasia, Macrophage    | 2  3  3  2  4  3  3  2  4  3  3  3  2  3  3  1  3  2  3  2  3  3  3  3  3|             
      Alveolus, Proteinosis                | 4  4  3  3  3  4  3  4  4  4  4  3  4  3  4  3  4  3  4  3  3  3  4  2  4|             
      Bronchus, Hyperplasia, Lymphoid      |                               1        4     1  1     3  1  3        1  1|             
      Interstitium, Infiltration Cellular  | 3  2  3  1  2  2  3  2  3  3  2  3  4     2  1  2  1  2  2  2  2  2  3  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|             
                                           | 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                        2  2              2              1|             
      Olfactory Epithelium, Atrophy        | 1  1     1     1  1  1     2  1     1  1  1  1        1  1  2     1  1   |             
      Olfactory Epithelium, Degeneration   |       1                    1              1           1  1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                    4                     |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |                                                                         1|             
      Pelvis, Inflammation                 |                                                          3               |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                     +                                    |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|             
                                           | 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                4                                                         |             
      Atrophy                              |                                                 3                        |             
      Basophilic Focus                     |                   X                                                      |             
      Degeneration                         |       2                                                                  |             
      Eosinophilic Focus                   |          X           X                                                   |             
      Infarct                              |                                                                         4|             
      Infiltration Cellular, Lymphocyte    |    2                                                                    4|             
      Inflammation                         |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                4                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Oral Mucosa                             |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                            4                                             |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                   1      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Atrophy                              |                                                                          |             
      Degeneration                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                2         |             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|             
                                           | 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 4                        |             
      Pars Distalis, Hyperplasia           | 3                                         3  3     4        3     4      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
      Follicular Cell, Hyperplasia         | 2  1     1  2     3  3  1        1     2  2  1     1  2  2  2  1  1  3  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
      Thoracic, Inflammation               |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                2                                3        3               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |          X     X                             X                 X  X      |             
      Hemorrhage                           |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation                         |                                                                          |             
      Endometrium, Hyperplasia             |    3        2        3           3     3  3  3     3  3                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +                                                                     |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |                               3                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +  +  +                                +         |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Pancreatic, Hyperplasia              |                            3                                             |             
      Pancreatic, Inflammation             |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 3  2  1  1  2  1  1  3  1  2     2  3  3  2  2  4  2  4  3  4     3  2  3|             
      Hyperplasia, Macrophage              | 2  2  1     1  1  1  2  2  2     2  2  2  2  2     2     1        3  1  1|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|             
                                           | 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                              3              2           4|             
      Inflammation                         |                                  3     3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | I  M  M  I  +  +  M  I  +  +  +  +  M  M  M  M  +  M  +  M  +  M  +  M  +|             
      Hyperplasia, Lymphoid                |                                                 4                        |             
      Inflammation                         |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                3  1        2                       3                     |             
      Hyperplasia, Lymphoid                |          2     3     2                    2  2                       1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +|             
      Degeneration                         |                                     4              2        2            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2                       2     2        2     2                           |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pinna, Cyst Epithelial Inclusion     |                                                                          |             
      Pinna, Hyperkeratosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                X                                                         |             
      Inflammation                         |                                                                          |             
      Femur, Hyperostosis                  | X  X                                            X     X     X     X  X   |             
      Maxilla, Hyperostosis                |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Abscess                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  I  +  +  +  +  +  M  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   1     1  1  1                    1        1        1  1|             
      Inflammation, Chronic Active         | 3  2  1  2  2  1  3  1  1  2  1  2  1  3  2  2  2  2  2  2  2  2  3  3  2|             
      Alveolar Epithelium, Hyperplasia     | 3  2  1  2  2  2  3  2  3  2  1  2  1  3  3  2  2  2  2  2  1  1  2  2  2|             
      Alveolus, Hyperplasia, Macrophage    | 4  3  2  3  3  2  3  3  3  3  3  3  1  4  3  4  3  3  3  2  3  2  4  4  3|             
      Alveolus, Proteinosis                | 2  4  4  4  3  3  4  4  4  2  2  3  3  4  4  4  4  4  2  4  3  4  3  1  3|             
      Bronchus, Hyperplasia, Lymphoid      | 1  1     1  1  2  1  1  1  1        1  1  1     1  1  3  1  1  1  1  2   |             
      Interstitium, Infiltration Cellular  | 3  2  2  3  3  1  2  2  2  2  2  2  2  2  2  1  2  2  4  2  3  1  2  2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|             
                                           | 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1.2MG/M3                               | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  | 1     1     2                       2        2                 2  2      |             
      Olfactory Epithelium, Atrophy        |    1  1  1  1           1  1  1  1        2  1  1  1  1  1     1  1  1  1|             
      Olfactory Epithelium, Degeneration   |    1        1  1                 1        1                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |       +                                               +                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |                                                                          |             
      Pelvis, Inflammation                 |                                                                          |             
      Renal Tubule, Pigmentation,          |                                                                          |             
          Hemosiderin                      |                4                                                         |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 4| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 7| 3| 8| 7|                                            |            |
                                           | 3| 5| 3| 3| 2| 5| 7| 3| 0| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.2MG/M3                               | 6| 6| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 6| 8| 0| 1| 3| 5| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +     +  +                                                |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +     +  +                                                |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +     +  +                                                |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +  M     +  +                                                |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +                                                |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +     +  +                                                |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +     +  +                                                |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +     +  +                                                |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +     +  +                                                |  58        |
      Angiectasis                          |       3                                                                  |      3  3.7|
      Atrophy                              |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |      1     |
      Degeneration                         |                                                                          |      3  2.7|
      Eosinophilic Focus                   |                                                                          |      3     |
      Infarct                              |                                                                          |      2  4.0|
      Infiltration Cellular, Lymphocyte    |                2                                                         |      3  2.7|
      Inflammation                         |                                                                          |      1  3.0|
      Mixed Cell Focus                     |             X                                                            |      1     |
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Oral Mucosa                             |    +                                                                     |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +     +  +                                                |  57        |
      Inflammation                         |                                                                          |      1  4.0|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +     +  +                                                |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +     +  +                                                |  56        |
      Hyperplasia, Focal, Squamous         |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +     +  +                                                |  56        |
      Inflammation                         |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Developmental Malformation           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +     +  +                                                |  57        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +     +  +                                                |  58        |
      Angiectasis                          |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 4| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 7| 3| 8| 7|                                            |            |
                                           | 3| 5| 3| 3| 2| 5| 7| 3| 0| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.2MG/M3                               | 6| 6| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 6| 8| 0| 1| 3| 5| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                          |      1  4.0|
      Degeneration                         |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +     +  +                                                |  58        |
      Angiectasis                          |       3                                                                  |      1  3.0|
      Hyperplasia                          |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +     +  +                                                |  57        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +     +  +                                                |  53        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +     +  +                                                |  58        |
      Angiectasis                          |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           | 2  3                 2                                                   |     11  2.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +     +  +                                                |  58        |
      Inflammation                         |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |    3     3  1  1     2                                                   |     37  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Thoracic, Inflammation               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +     +  +                                                |  51        |
      Atrophy                              |                                                                          |      8  2.8|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +     +  +                                                |  58        |
      Abscess                              |                                                                          |      1  4.0|
      Cyst                                 |          X              X                                                |     11  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Periovarian Tissue, Cyst             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +     +  +                                                |  58        |
      Cyst                                 |                                                                          |      3  2.0|
      Inflammation                         |    2        3                                                            |      3  2.3|
      Endometrium, Hyperplasia             |    3     3           3                                                   |     19  2.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +     +  +                                                |  57        |
      Erythroid Cell, Hyperplasia          |             2                                                            |      1  2.0|
      Myeloid Cell, Hyperplasia            |                         2                                                |      5  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +     +                                                   |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 4| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 7| 3| 8| 7|                                            |            |
                                           | 3| 5| 3| 3| 2| 5| 7| 3| 0| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.2MG/M3                               | 6| 6| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 6| 8| 0| 1| 3| 5| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Iliac, Hyperplasia, Lymphoid         |                4     4                                                   |      2  4.0|
      Pancreatic, Hyperplasia              |                                                                          |      1  3.0|
      Pancreatic, Inflammation             |                                                                          |      1  4.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +     +  +                                                |  58        |
      Hyperplasia, Lymphoid                | 4  4  1  2  4  3     3  2                                                |     51  2.4|
      Hyperplasia, Macrophage              | 1  2  2  3  2  1     3  2                                                |     47  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +     +  +                                                |  58        |
      Hyperplasia, Lymphoid                |                4                                                         |      4  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +     +  +                                                |  55        |
      Hyperplasia, Lymphoid                |             3                                                            |      6  2.8|
      Inflammation                         |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  +     +  M                                                |  29        |
      Hyperplasia, Lymphoid                |             4  1                                                         |      4  3.3|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +     +  +                                                |  58        |
      Hematopoietic Cell Proliferation     |             2           3                                                |      8  2.3|
      Hyperplasia, Lymphoid                | 2  2  2     3  4     3                                                   |     19  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +     +  +                                                |  53        |
      Degeneration                         |                                                                          |      7  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +     +  +                                                |  58        |
      Hyperplasia                          |    1           2                                                         |      7  1.9|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +     +  +                                                |  58        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Pinna, Cyst Epithelial Inclusion     |                                                                          |      1     |
      Pinna, Hyperkeratosis                |                         3                                                |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +     +  +                                                |  57        |
      Hyperostosis                         |                                                                          |      1     |
      Inflammation                         |                                                                          |      1  3.0|
      Femur, Hyperostosis                  |                      X                                                   |     10     |
      Maxilla, Hyperostosis                |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 7| 7| 7| 4| 7| 5| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 6| 3| 3| 3| 7| 3| 8| 7|                                            |            |
                                           | 3| 5| 3| 3| 2| 5| 7| 3| 0| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    1.2MG/M3                               | 6| 6| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 6| 8| 0| 1| 3| 5| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +     +  +                                                |  58        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Abscess                              |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  I  +  +  +  +     I  +                                                |  51        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +     +  +                                                |  58        |
      Fibrosis                             |          1           1                                                   |     17  1.1|
      Inflammation, Chronic Active         | 3  3  1  3  3  3     3  2                                                |     56  2.0|
      Alveolar Epithelium, Hyperplasia     | 2  2  2  2  2  3     2  2                                                |     57  2.1|
      Alveolus, Hyperplasia, Macrophage    | 4  4  3  4  3  3     3  3                                                |     58  2.9|
      Alveolus, Proteinosis                | 4  3  4  4  3  3     4  4                                                |     58  3.4|
      Bronchus, Hyperplasia, Lymphoid      |    3  2     3  2        2                                                |     34  1.5|
      Interstitium, Infiltration Cellular  | 2  2  2  2  3  3     2  2                                                |     57  2.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +     +  +                                                |  58        |
      Inflammation, Acute                  | 2  1                                                                     |     13  1.7|
      Olfactory Epithelium, Atrophy        | 1     1  1  1  1     1                                                   |     41  1.1|
      Olfactory Epithelium, Degeneration   |       1        1                                                         |     12  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +     +  +                                                |  56        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +     +  +                                                |  58        |
      Hydronephrosis                       |                                                                          |      1  4.0|
      Infiltration Cellular, Lymphocyte    |                      2                                                   |      1  2.0|
      Metaplasia, Osseous                  |                2                                                         |      1  2.0|
      Nephropathy                          |                                                                          |      1  1.0|
      Pelvis, Inflammation                 |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation,          |                                                                          |            |
          Hemosiderin                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +     +  +                                                |  57        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 1| 4| 1| 1| 1| 1| 0| 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1|              |            |
                             DAY ON TEST   | 7| 7| 9| 7| 9| 9| 9| 9| 7| 7| 7| 9| 9| 7| 9| 9| 7| 7| 4| 9|              |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    1.2MG/M3                               | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 6| 6| 6| 7| 7| 7|              |      L     |
    LUNG TOX                               | 4| 5| 0| 1| 6| 7| 3| 4| 6| 8| 1| 5| 0| 9| 1| 7| 9| 2| 4| 6|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +              +  M  +        +           +  +                  |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +              +  +  +        +           +  +                  |   7        |
      Hyperplasia, Lymphoid                |          2                                         2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Liver                                   |          +              +  +  +        +           +  +                  |   7        |
      Atrophy                              |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +              +  +  +        +           +  +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +              +  +  +        +           +  +                  |   7        |
      Cardiomyopathy                       |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |          +              +  +  +        +           +  +                  |   7        |
      Degeneration                         |                         1                             2                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          M              +  +  +        +           +  +                  |   6        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +              +  +  +        +           +  +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                            +                                             |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +              M  +  M        +           +  +                  |   5        |
      Ectasia                              |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Uterus                                  |          +        +     +  +  +        +           +  +                  |   8        |
      Endometrium, Hyperplasia             |                            2           2           2                     |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 1| 4| 1| 1| 1| 1| 0| 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1|              |            |
                             DAY ON TEST   | 7| 7| 9| 7| 9| 9| 9| 9| 7| 7| 7| 9| 9| 7| 9| 9| 7| 7| 4| 9|              |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    1.2MG/M3                               | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 6| 6| 6| 7| 7| 7|              |      L     |
    LUNG TOX                               | 4| 5| 0| 1| 6| 7| 3| 4| 6| 8| 1| 5| 0| 9| 1| 7| 9| 2| 4| 6|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   |       +  +     +  +     I  +  +  +     +     +     +  +                  |  11        |
      Hyperplasia, Lymphoid                |          2                 3  3        2           2  3                  |      6  2.5|
      Hyperplasia, Macrophage              |          1                 1  1  1     1           1                     |      6  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |          +     +  +     +  +  +  +     +           +  +                  |  10        |
      Hyperplasia, Lymphoid                |          2                       1     3                                 |      3  2.0|
      Hyperplasia                          |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +              +  +  +        +           +  +                  |   7        |
      Hyperplasia, Lymphoid                |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 |       I  M     +  M     M  +  M  M     M     I     M  +                  |   3        |
      Hyperplasia, Lymphoid                |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |          +              +  +  +        +           +  +                  |   7        |
      Atrophy                              |                         3                                                |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                       2                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +              +  +  +        +           +  M                  |   6        |
      Degeneration                         |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +              +  +  +        +           +  +                  |   7        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +              +  +  +        +           +  +                  |   7        |
      Inflammation                         |                         2                                                |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +              +  +  +        +           +  +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +              +  +  +        +           +  +                  |   7        |
      Thalamus, Degeneration, Focal        |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |          +              +  +  +        +           M  +                  |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +     +  +     +  +  +  +     +     +     +  +                  |  12        |
      Inflammation, Chronic Active         |       1  1     2  1     1  1  1  1     2     1     2  2                  |     12  1.3|
      Alveolar Epithelium, Hyperplasia     |          2                 1  2        1           2  2                  |      6  1.7|
      Alveolus, Hyperplasia, Macrophage    |       1  2     1  1     1  3  3  2     3     1     3  2                  |     12  1.9|
      Alveolus, Proteinosis                |       1  4     2  1        2  4  2     4     1     4  4                  |     11  2.6|
      Bronchus, Hyperplasia, Lymphoid      |          2                 1  1        1                                 |      4  1.3|
      Interstitium, Infiltration Cellular  |          1     1  1        3  2  2     2     2     1  3                  |     10  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 1| 4| 1| 1| 1| 1| 0| 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1|              |            |
                             DAY ON TEST   | 7| 7| 9| 7| 9| 9| 9| 9| 7| 7| 7| 9| 9| 7| 9| 9| 7| 7| 4| 9|              |            |
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    1.2MG/M3                               | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 6| 6| 6| 7| 7| 7|              |      L     |
    LUNG TOX                               | 4| 5| 0| 1| 6| 7| 3| 4| 6| 8| 1| 5| 0| 9| 1| 7| 9| 2| 4| 6|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    |       +  +     +  +     +  +  +  +     +     +     +  +                  |  12        |
      Inflammation, Acute                  |                         2                                                |      1  2.0|
      Olfactory Epithelium, Atrophy        |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |          +              +  +  +        +           +  +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +     +  +     +  +  +  +     +     +     +  +                  |  12        |
      Nephropathy                          |                                                       2                  |      1  2.0|
      Glomerulus, Inflammation             |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +              +  +  +        +           +  +                  |   7        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 5| 5| 4| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 8| 8| 4| 6| 7| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3|             
                                           | 0| 4| 6| 4| 1| 6| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  +     M  +  +  M  +  +  +  +  +  +  M  +  M  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | M  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Degeneration                         |                   3                                                      |             
      Eosinophilic Focus                   |                                     X                                    |             
      Infarct                              |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation                         |                         2                             1                  |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |             2                                            1     4         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                   +      |             
      Developmental Malformation           |                                                                   X      |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X                        |             
      Hyperplasia, Focal                   |                                     2                                    |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +     M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 5| 5| 4| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 8| 8| 4| 6| 7| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3|             
                                           | 0| 4| 6| 4| 1| 6| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                   1                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |             1     1     1  2  2     1  1  2  1  2                 3     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |    +  +     +           +        +                          +        +   |             
      Concretion                           |                                  2                                       |             
      Inflammation                         |    2        2                    1                                   2   |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2                          2|             
      Ectasia                              | 4        3        3  3     3     3  3     2  2  4              1  2      |             
      Hyperplasia                          |                                        1                                 |             
      Inflammation, Chronic                |       4     4           4     2                    2     4           3  4|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |    3  4     3           3        4     2        2  2        4        2  2|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +     +                    +              +  +        +           +|             
      Iliac, Hyperplasia, Lymphoid         |       2     3                    4                                       |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Iliac, Inflammation                  |                                                             4            |             
      Iliac, Pigmentation                  |             1                                                            |             
      Inguinal, Hyperplasia, Lymphoid      |             3                    4                 2                     |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                         4|             
      Inguinal, Pigmentation               |                                                                          |             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |       3                                                                  |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  +  +     M  +  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  M|             
      Hyperplasia, Lymphoid                |                      2     4                                             |             
      Hyperplasia, Macrophage              |                                                                          |             
      Hyperplasia, Plasma Cell             |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 5| 5| 4| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 8| 8| 4| 6| 7| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3|             
                                           | 0| 4| 6| 4| 1| 6| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    3                     |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         3|             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation                         |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  M  M     M  +  +  M  M  +  M  +  M  M  +  M  M  M  M  +  M  M  M|             
      Hyperplasia, Lymphoid                | 3                    2                                                   |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3     2                                               4            |             
      Hyperplasia, Lymphoid                |                      2        2        2        3  4           3     2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +     +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Degeneration                         |       3  3  3     4                                2     3     4         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M     M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Inflammation                         |                                                                          |             
      Pinna, Hyperkeratosis                |                                                                   2      |             
      Prepuce, Inflammation                |    4  3     4           4        4     4        4                    3   |             
      Tail, Inflammation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Medulla, Demyelination               |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                  3                                       |             
      Alveolus, Hyperplasia, Macrophage    |                            3  4              3                           |             
      Bronchus, Hyperplasia, Lymphoid      |             1        2  1  2     2  1     1     1                       1|             
      Interstitium, Infiltration Cellular  |    1     1                    1              1     1                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration   |                                  1                          1            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 5| 5| 4| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7|             
                             DAY ON TEST   | 4| 8| 8| 4| 6| 7| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3|             
                                           | 0| 4| 6| 4| 1| 6| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|             
                                           | 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |    2  3                                                              3   |             
      Infiltration Cellular, Lymphocyte    |                      2     2                                             |             
      Inflammation                         |       4                 2                                   4  3         |             
      Nephropathy                          | 1           1                             1           1                  |             
      Pelvis, Inflammation                 |                                                 2                        |             
      Renal Tubule, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                             +            |             
      Inflammation                         |                                                             1            |             
                                            __________________________________________________________________________|             
   Urethra                                 |    +                                            +                        |             
      Concretion                           |    3                                            3                        |             
      Inflammation                         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                             X            |             
      Crystals                             |       4                                                                  |             
      Inflammation                         |       4     1           1                       3           4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4|             
                                           | 7| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  M  +  M  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X                                                                     |             
      Degeneration                         |                                                                          |             
      Eosinophilic Focus                   |    X                                                                     |             
      Infarct                              |                                                 4        4               |             
      Infiltration Cellular, Lymphocyte    |       2                                                                  |             
      Inflammation                         |                                                                          |             
      Mixed Cell Focus                     |                                        X                                 |             
      Necrosis                             |    2        2                             3                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                                                            |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                    2                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                    +     +              +|             
      Developmental Malformation           |                                                                          |             
      Inflammation                         |                                                    3     3              2|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4|             
                                           | 7| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    1  1                 2     2        1     1  1  1  2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                          +               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |    +           +        +           +                                    |             
      Concretion                           |                3        2                                                |             
      Inflammation                         |                                     3                                    |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         3                                                |             
      Ectasia                              | 3           3                    1  1           3  3  3     3  3  1     2|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                | 4     4  3     1  4  2  1     2        4  3  2        3              4   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2                                                   |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |    2                                                                     |             
      Myeloid Cell, Hyperplasia            |          3     3        4  4  3     2                       2     3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +  +        +  +  +  +                    +     +            |             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |    4                    3     2  2                    4     4            |             
      Iliac, Inflammation                  |                                                                          |             
      Iliac, Pigmentation                  |                                                       1                  |             
      Inguinal, Hyperplasia, Lymphoid      |                2              4                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                            4                                             |             
      Inguinal, Pigmentation               |                                  1                                       |             
      Lumbar, Hyperplasia, Plasma Cell     |                            3                                             |             
      Lumbar, Pigmentation                 |                            2                                             |             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +     +  I  M  +  M  +  +  +  M  M  +  +  M  I  I  +  +|             
      Hyperplasia, Lymphoid                |                                              1                       2   |             
      Hyperplasia, Macrophage              |             3                                                            |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4|             
                                           | 7| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |          4                                                               |             
      Hyperplasia, Plasma Cell             |                                                                      3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation                         |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  I  M  M  +  M  M  +  M  M  M  M  M  M  I  +  M  M  M  M  M  M  M  M  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              |             2                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |    3                          2                             3            |             
      Hyperplasia, Lymphoid                |             2     2     3  3     4                                2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  I  M  +  M  M  M  M  +  M  +  +  M  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |    3                                                              2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                            2                                             |             
      Inflammation                         |                            4                                      4      |             
      Pinna, Hyperkeratosis                |                                                                          |             
      Prepuce, Inflammation                |          4     4        2     4     4        3        4                  |             
      Tail, Inflammation                   |    4                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Medulla, Demyelination               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                         1                                                |             
      Alveolar Epithelium, Hyperplasia     |                                                 4                       1|             
      Alveolus, Hyperplasia, Macrophage    |       2                                   2        2                     |             
      Bronchus, Hyperplasia, Lymphoid      | 1        1                       1        1  1  1     1        1        1|             
      Interstitium, Infiltration Cellular  |             1        1                                               1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration   |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4|             
                                           | 7| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.0MG/M3                               | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|             
                                           | 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                  3                    2           3      |             
      Infiltration Cellular, Lymphocyte    | 1     2           1                             2                        |             
      Inflammation                         |                                                                          |             
      Nephropathy                          |          1        1  1  1        1                                       |             
      Pelvis, Inflammation                 |    2                    2     2                             2            |             
      Renal Tubule, Degeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                         +                             +           +      |             
      Concretion                           |                         3                             3           3      |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |    X                                                                     |             
      Calculus Micro Observation Only      |                                                                          |             
      Crystals                             |                                                                          |             
      Inflammation                         |    4                    4     4  1                          4            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 4| 7| 5| 5| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 1| 4| 3| 6| 3| 8| 8| 4| 4| 3|                                            |            |
                                           | 3| 0| 7| 3| 7| 8| 5| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0MG/M3                               | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 9| 0| 1| 3| 4| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  M  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |          3                                                               |      1  3.0|
      Basophilic Focus                     |             X                                                            |      2     |
      Degeneration                         |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                                                                          |      2     |
      Infarct                              |                                                                          |      2  4.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      2  1.5|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             | 2                                                                        |      7  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acinus, Atrophy                      |                      2                                                   |      1  2.0|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   4        |
      Developmental Malformation           |                                                                          |      1     |
      Inflammation                         |                                                                          |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cardiomyopathy                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 4| 7| 5| 5| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 1| 4| 3| 6| 3| 8| 8| 4| 4| 3|                                            |            |
                                           | 3| 0| 7| 3| 7| 8| 5| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0MG/M3                               | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 9| 0| 1| 3| 4| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +                                             |  56        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Follicular Cell, Hyperplasia         |    1        1  2  2     2  1                                             |     27  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +                                                                        |  12        |
      Concretion                           | 4                                                                        |      4  2.8|
      Inflammation                         |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      3  2.3|
      Ectasia                              | 2        2        2        4                                             |     27  2.6|
      Hyperplasia                          |                         3                                                |      2  2.0|
      Inflammation, Chronic                |    3        2  4                                                         |     24  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Erythroid Cell, Hyperplasia          |    2                                                                     |      2  2.0|
      Myeloid Cell, Hyperplasia            | 4              3  2        2                                             |     23  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                    +                                                   |  18        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      3  3.0|
      Iliac, Hyperplasia, Plasma Cell      | 4                                                                        |      7  3.3|
      Iliac, Inflammation                  |                                                                          |      1  4.0|
      Iliac, Pigmentation                  |                                                                          |      2  1.0|
      Inguinal, Hyperplasia, Lymphoid      | 2                                                                        |      6  2.8|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 4| 7| 5| 5| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 1| 4| 3| 6| 3| 8| 8| 4| 4| 3|                                            |            |
                                           | 3| 0| 7| 3| 7| 8| 5| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0MG/M3                               | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 9| 0| 1| 3| 4| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inguinal, Pigmentation               |                                                                          |      1  1.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |      1  3.0|
      Lumbar, Pigmentation                 |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  M  I  +  M  +                                             |  39        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.3|
      Hyperplasia, Macrophage              |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  M  +  +  +  M  +  M  +  M                                             |  51        |
      Hyperplasia, Lymphoid                |       2                                                                  |      3  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Hyperplasia, Macrophage              | 3                                                                        |      1  3.0|
      Inflammation                         |    2                                                                     |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M  M  M  M  M  +  +  M                                             |  12        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Hyperplasia, Macrophage              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hematopoietic Cell Proliferation     | 3  2                                                                     |      8  2.8|
      Hyperplasia, Lymphoid                |       2     2           1                                                |     16  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M                                             |  46        |
      Degeneration                         | 4                    3                                                   |     11  3.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Alopecia                             |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      2  4.0|
      Pinna, Hyperkeratosis                |                                                                          |      1  2.0|
      Prepuce, Inflammation                |                4                                                         |     16  3.7|
      Tail, Inflammation                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 4| 7| 5| 5| 7| 7| 6|                                            |            |
                             DAY ON TEST   | 1| 4| 3| 6| 3| 8| 8| 4| 4| 3|                                            |            |
                                           | 3| 0| 7| 3| 7| 8| 5| 1| 1| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.0MG/M3                               | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
                                           | 9| 0| 1| 3| 4| 6| 7| 8| 9| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Medulla, Demyelination               |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  M  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.7|
      Alveolus, Hyperplasia, Macrophage    |                                                                          |      6  2.7|
      Bronchus, Hyperplasia, Lymphoid      |       1     2              1                                             |     21  1.2|
      Interstitium, Infiltration Cellular  |    1  1                                                                  |     10  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Olfactory Epithelium, Atrophy        |             1                                                            |      1  1.0|
      Olfactory Epithelium, Degeneration   |                      1                                                   |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hydronephrosis                       |                   2        2                                             |      8  2.5|
      Infiltration Cellular, Lymphocyte    |                            2                                             |      7  1.7|
      Inflammation                         | 4                                                                        |      5  3.4|
      Nephropathy                          |                                                                          |      9  1.0|
      Pelvis, Inflammation                 |                                                                          |      5  2.0|
      Renal Tubule, Degeneration           |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ureter                                  | +                                                                        |   2        |
      Inflammation                         | 4                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                   +                                                      |   6        |
      Concretion                           |                                                                          |      5  3.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Calculus Gross Observation           |                                                                          |      1     |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Crystals                             |                                                                          |      1  4.0|
      Inflammation                         | 4                                                                        |     11  3.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 1| 4| 4| 4| 0| 1| 1| 4| 1| 1| 1| 1| 4| 4| 1| 1| 4|              |            |
                             DAY ON TEST   | 7| 7| 7| 9| 7| 7| 7| 6| 9| 9| 7| 9| 9| 9| 9| 7| 3| 9| 9| 7|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.0MG/M3                               | 0| 1| 1| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7|              |      L     |
    LUNG TOX                               | 6| 3| 8| 3| 8| 0| 1| 2| 3| 4| 5| 1| 4| 5| 8| 5| 6| 8| 2| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +        +  +  +                          +        +               |   7        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +        +  +  +                          A        +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +        +  +  A                          A        +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +        +  +  +                          A        +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +        +  +  +                          A        +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +        +  +  A                          A        +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +        +  +  A                          A        +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +        +  +  A                          A        +               |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +     +        +  +  +                          +        +               |   7        |
      Angiectasis                          |                                                 3                        |      1  3.0|
      Atrophy                              |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +        +  +  +                          +        +               |   7        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +        +  +  +                          +        +               |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | M     +        M  +  +                          +        +               |   5        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +        +  +  +                          +        +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +        +  +  +                          +        +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +     +        +  +  +                          +        +               |   7        |
      Hypertrophy                          |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +     +        +  +  +                          +        +               |   7        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +        +  +  +                          +        +               |   7        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M        +  M  +                          +        +               |   5        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +     +        +  +  +                          +        +               |   7        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +        +  +  +                          +        +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +        +  +  +                          +        +               |   7        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +        +  +  +                          +        +               |   7        |
      Ectasia                              | 1     2        2                                2        2               |      5  1.8|
      Inflammation, Chronic                |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +        +  +  +                          +        +               |   7        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +     +        +  +  +                          +        +               |   7        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +        +  +  +                          +        +               |   7        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 1| 4| 4| 4| 0| 1| 1| 4| 1| 1| 1| 1| 4| 4| 1| 1| 4|              |            |
                             DAY ON TEST   | 7| 7| 7| 9| 7| 7| 7| 6| 9| 9| 7| 9| 9| 9| 9| 7| 3| 9| 9| 7|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.0MG/M3                               | 0| 1| 1| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7|              |      L     |
    LUNG TOX                               | 6| 3| 8| 3| 8| 0| 1| 2| 3| 4| 5| 1| 4| 5| 8| 5| 6| 8| 2| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +        +  +  +                          +        +               |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +                                             |   1        |
      Lumbar, Hyperplasia, Lymphoid        |                            3                                             |      1  3.0|
      Lumbar, Pigmentation                 |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | I     +        +  +  M     +     +  M     M     +  +     +               |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M     M        M  +  M                          +        +               |   3        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +        +  +  +                          +        +               |   7        |
      Hemorrhage, Chronic                  | 2                                                                        |      1  2.0|
      Hyperplasia, Lymphoid                | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M     M        M  M  M     +     I  +     I     M  M     +               |   3        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +        +  +  +                          +        +               |   7        |
      Atrophy                              |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +        +  +  +                          +        +               |   7        |
      Degeneration                         |                      4                                                   |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M     M        M  M  M                          M        M               |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +        +  +  +                          +        +               |   7        |
      Fibrosis                             |                                                 3                        |      1  3.0|
      Necrosis                             |                                                 4                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +     +        +  +  +                          +        +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +        +  +  +                          +        +               |   7        |
      Medulla, Degeneration, Focal         |                                                 2                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +     +        +  +  +                          +        +               |   7        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +        +  +  +     +     +  +     +     +  +     +               |  12        |
      Bronchus, Hyperplasia, Lymphoid      |                1                                1        1               |      3  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +        +  +  +     +     +  +     +     +  +     +               |  12        |
      Olfactory Epithelium, Respiratory    |                                                                          |            |
          Epithelium, Degeneration         |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +        +  +  I                          +        +               |   6        |
      Inflammation, Focal                  | 1              1                                         1               |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 1| 4| 4| 4| 0| 1| 1| 4| 1| 1| 1| 1| 4| 4| 1| 1| 4|              |            |
                             DAY ON TEST   | 7| 7| 7| 9| 7| 7| 7| 6| 9| 9| 7| 9| 9| 9| 9| 7| 3| 9| 9| 7|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      A     |
    0.0MG/M3                               | 0| 1| 1| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7|              |      L     |
    LUNG TOX                               | 6| 3| 8| 3| 8| 0| 1| 2| 3| 4| 5| 1| 4| 5| 8| 5| 6| 8| 2| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +     +        +  +  +     +     +  +     +     +  +     +               |  12        |
                                            __________________________________________________________________________|____________|
   Urethra                                 | +                 +                                                      |   2        |
      Calculus Micro Observation Only      | X                 X                                                      |      2     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +        +  +  +                          +        +               |   7        |
      Calculus Micro Observation Only      |                X                                                         |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 4| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 7| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7|             
                                           | 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 6| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.6MG/M3                               | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  M  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  M  +  M  +  +  +  +  +  +  +  +  A  M  M  A  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal, Lymphoid         |                               4                                          |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                 3                        |             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Infarct                              |                                  4                                       |             
      Necrosis                             |                   1                                         4            |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Regeneration                         |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |       2                                                           2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |       2                                                                  |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
      Necrosis                             |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 4| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 7| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7|             
                                           | 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 6| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.6MG/M3                               | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |    1        1     1     1  1        1     1        2  1  1  1  1        2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   | +     +                                                     +     +     +|             
      Concretion                           |                                                                          |             
      Inflammation                         | 4                                                           4     4     4|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              | 3  3  2  2  3  2              1     3        2     2  3     3           2|             
      Inflammation, Chronic                |                         3     1  3  2     2              4     4  2  4   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |       2        2                                                         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                2                 2                          2            |             
      Myeloid Cell, Hyperplasia            |          4                          3                 3  3        3     2|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +                                            +        +         |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Iliac, Inflammation                  |                                                                          |             
      Iliac, Pigmentation                  |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      | 2                                                                        |             
      Inguinal, Hyperplasia, Plasma Cell   |          3                                            3                  |             
      Inguinal, Inflammation               |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  M  +  +  +  M  +  +  +  I|             
      Hyperplasia, Lymphoid                |    4        2     2  3  1  3  2  1     1  4        4  2  1     2  1  3   |             
      Hyperplasia, Macrophage              | 1  2     1     1  2  2  2  2  1  2  2  2  2        1  2  2     2  2  1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 4| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 7| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7|             
                                           | 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 6| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.6MG/M3                               | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                | 3                 2                                                      |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  +  +  +  M  I  I  I  I  M  M  M  M  I  +  M  +  M  M  M  I  M  I  M|             
      Hyperplasia, Lymphoid                |                                                    3                     |             
      Hyperplasia, Macrophage              |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                 3                        |             
      Hematopoietic Cell Proliferation     |       3  2     3                 2     2                    3            |             
      Hyperplasia, Lymphoid                | 2                 2  2                             3           2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                                                 3                        |             
      Degeneration                         |       3     3  3                       2                          2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parakeratosis                        |                                                                          |             
      Prepuce, Inflammation                | 4        4                          4                 4  3               |             
      Tail, Hyperkeratosis                 |                                                          3               |             
      Tail, Inflammation                   |                                                                          |             
      Tail, Necrosis                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Hyperostosis                         |                                                    X                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, White Matter,            |                                                                          |             
          Degeneration, Focal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |             1           1                                                |             
      Infiltration Cellular                |                                                                          |             
      Inflammation, Chronic Active         | 1  3     2  1     1  1  1  1  1  2  2  2  3  2     3  2  2  2  1  2  2  2|             
      Alveolar Epithelium, Hyperplasia     | 1  2  1  2  2     2  2  1  2  2  2  2  2  2  1     2  2  3  2  2  2  2  1|             
      Alveolus, Hyperplasia, Macrophage    | 2  3  1  1  3  2  2  3  2  2  1  2  2  2  3  2     2  2  2  2  3  2  3  2|             
      Alveolus, Proteinosis                | 3  3  3  3  4  2  4  3  4  3  3  2  2  3  3  3     4  3  4  3  3  4  3  4|             
      Bronchus, Hyperplasia, Lymphoid      |    2        1     1  1  1  1              1        1           1     1   |             
      Interstitium, Infiltration Cellular  | 1  3  1  1  2  1  2  2  2  2     1  2  2  1  2     2  2  2  2  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 4| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5|             
                             DAY ON TEST   | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 7| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7|             
                                           | 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 6| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0.6MG/M3                               | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|             
                                           | 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |    2  1           1  1  1  1        1                    1        2     1|             
      Olfactory Epithelium, Degeneration   |       1           1                                      1           1   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                                     1                                   3|             
      Infiltration Cellular, Lymphocyte    |                                  2                                       |             
      Inflammation                         |                                                                          |             
      Nephropathy                          |       1                          1  1              1           1         |             
      Cortex, Atrophy                      |                                                                          |             
      Pelvis, Inflammation                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                     +                       +           +|             
      Concretion                           |                                     3                       3           3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                          |             
      Hyperplasia                          | 2                                                                        |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 4| 7| 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8|             
                                           | 4| 6| 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 6| 7| 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M     A  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  A  +  +  +|             
      Epithelium, Hyperplasia              |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | A     A  +  +  +  +  M  +  M  M  +  M  M  +  +  +  M  M  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A     A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Hyperplasia, Focal, Lymphoid         |                                                                          |             
      Lymphoid Tissue, Hyperplasia         |                                     3                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A     A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A     A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A     A  +  +  +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                             3                                   4|             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                                                                         X|             
      Eosinophilic Focus                   |                                                          X               |             
      Hepatodiaphragmatic Nodule           |                                              X     X                     |             
      Infarct                              |                                                 4                        |             
      Necrosis                             |          4           4                                3        4         |             
      Pigmentation, Hemosiderin            |                                                                      3   |             
      Regeneration                         |                                                                      3   |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                   1      |             
      Acinus, Atrophy                      |                                                                   2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                                                         2|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                              +                           |             
      Inflammation                         |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Hyperplasia, Focal                   |                                                             1            |             
      Hyperplasia                          |                                  2                                       |             
      Hypertrophy, Focal                   |                                     1                                    |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 4| 7| 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8|             
                                           | 4| 6| 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 6| 7| 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |          1     2  2     1        2        1              1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |       +                 +                             +                  |             
      Concretion                           |       3                 3                                                |             
      Inflammation                         |       4                                                                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Ectasia                              |       3        2     2  2  3        2  2  3  3  2     2     3  2  2  2   |             
      Inflammation, Chronic                |          2           4                                   4               |             
                                            __________________________________________________________________________|             
   Prostate                                | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                         2                                                |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Germinal Epithelium, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            |                      3  2  3  3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                      +  +  +  +  +                                       |             
      Iliac, Hyperplasia, Plasma Cell      |                               4                                          |             
      Iliac, Inflammation                  |                                                                          |             
      Iliac, Pigmentation                  |                                  3                                       |             
      Inguinal, Hyperplasia, Lymphoid      |                      3  3        3                                       |             
      Inguinal, Hyperplasia, Plasma Cell   |                            3                                             |             
      Inguinal, Inflammation               |                                                                          |             
      Lumbar, Pigmentation                 |                                  2                                       |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | A     +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       1  2  4  2  2     1  1     3  1  2  4  3     1        3  3  3     1|             
      Hyperplasia, Macrophage              |       2  1  2  2  2  2  2  2     2  1  2  1  2  2     1     2  3  2  2  2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  M  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A     +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 4| 7| 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8|             
                                           | 4| 6| 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 6| 7| 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |             3                             3  3                           |             
      Inflammation                         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | A     M  +  I  I  +  I  M  M  +  +  M  M  +  I  +  +  +  +  +  M  M  I  M|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
      Hyperplasia, Plasma Cell             |          2                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                      2        4                                   2  2   |             
      Hyperplasia, Lymphoid                |                                     2              2           2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | A     +  +  I  +  +  I  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Atrophy                              |                                                                          |             
      Degeneration                         |       4                 3                                            4   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | A     M  M  M  M  +  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | A     +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Parakeratosis                        |                                     1                                    |             
      Prepuce, Inflammation                |                      4  4  4                                             |             
      Tail, Hyperkeratosis                 |                                                                          |             
      Tail, Inflammation                   |                                                                          |             
      Tail, Necrosis                       |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                       X                  |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, White Matter,            |                                                                          |             
          Degeneration, Focal              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  M  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Infiltration Cellular                |                                                    3                     |             
      Inflammation, Chronic Active         |       1  1  3  1  2  1  1  2  1  1  1  1  2  1     1  3  1  3  3  3  1  1|             
      Alveolar Epithelium, Hyperplasia     |       1  1  2  2  3  1  2  2  1  1     2  2  2  1  2  2  2  2  1  2  2  1|             
      Alveolus, Hyperplasia, Macrophage    |       1  2  3  3  3  3  2  1  2  2  1  2  3  3  2  2  2  3  3  3  3  3  2|             
      Alveolus, Proteinosis                |       3  4  2  3  3  1  4  3  3  3  3  4  3  2  3  2  4  2  2  1  2  3  3|             
      Bronchus, Hyperplasia, Lymphoid      |             1  1  2        1           1  2  1     1  1  1  1  1  1     1|             
      Interstitium, Infiltration Cellular  |       1  1  2  2  1  2  1  1  1  1  1  2  3  2  1     2  2  3  1  2  1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5|             
                             DAY ON TEST   | 4| 7| 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8|             
                                           | 4| 6| 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    0.6MG/M3                               | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|             
                                           | 6| 7| 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Olfactory Epithelium, Atrophy        |       1  1  1  1  1  2        1  1     1     1  1           1  1     1   |             
      Olfactory Epithelium, Degeneration   |                1  1                                         1            |             
                                            __________________________________________________________________________|             
   Trachea                                 | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |       2                 2     2                                          |             
      Infiltration Cellular, Lymphocyte    |                                                             3     1      |             
      Inflammation                         |                         3                                                |             
      Nephropathy                          |             1        1                                2           2      |             
      Cortex, Atrophy                      |          2                    4                                          |             
      Pelvis, Inflammation                 |                               2                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |                      +                                +                  |             
      Concretion                           |                      3                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                         X                                                |             
      Calculus Micro Observation Only      |                               X                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation                         |                         3     4                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 1| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 4| 4| 3| 4| 4| 5| 6| 3|                                            |            |
                                           | 2| 1| 1| 1| 7| 0| 1| 5| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.6MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 8| 9| 1| 2| 3| 4| 6| 7| 8| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  50        |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  M  +                                             |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Hyperplasia, Focal, Lymphoid         |                                                                          |      1  4.0|
      Lymphoid Tissue, Hyperplasia         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      3  3.0|
      Atrophy                              |                                                                          |      1  3.0|
      Basophilic Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |    X                                                                     |      2     |
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Infarct                              |                                                                          |      2  4.0|
      Necrosis                             |    1        2           1                                                |      9  2.7|
      Pigmentation, Hemosiderin            |                                                                          |      1  3.0|
      Regeneration                         |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Inflammation                         |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cardiomyopathy                       |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 1| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 4| 4| 3| 4| 4| 5| 6| 3|                                            |            |
                                           | 2| 1| 1| 1| 7| 0| 1| 5| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.6MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 8| 9| 1| 2| 3| 4| 6| 7| 8| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Degeneration                         |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                            4                                             |      2  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Follicular Cell, Hyperplasia         | 3  2           1  1        2                                             |     25  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +                                                                        |   9        |
      Concretion                           |                                                                          |      2  3.0|
      Inflammation                         | 4                                                                        |      6  4.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                2                                                         |      1  2.0|
      Ectasia                              |                4     3     3                                             |     31  2.5|
      Inflammation, Chronic                |          4        4     4                                                |     15  3.1|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Germinal Epithelium, Atrophy         |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Erythroid Cell, Hyperplasia          |                                                                          |      3  2.0|
      Myeloid Cell, Hyperplasia            |    3                                                                     |     11  2.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +                       +                                                |  11        |
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  4.0|
      Iliac, Inflammation                  |                         3                                                |      1  3.0|
      Iliac, Pigmentation                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 1| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 4| 4| 3| 4| 4| 5| 6| 3|                                            |            |
                                           | 2| 1| 1| 1| 7| 0| 1| 5| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.6MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 8| 9| 1| 2| 3| 4| 6| 7| 8| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inguinal, Hyperplasia, Lymphoid      | 1                                                                        |      5  2.4|
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      3  3.0|
      Inguinal, Inflammation               |                         2                                                |      1  2.0|
      Lumbar, Pigmentation                 |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Hyperplasia, Lymphoid                | 1  1  3  1     3     1     2                                             |     40  2.1|
      Hyperplasia, Macrophage              | 2  2  2  1  1  1     1     1                                             |     47  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hyperplasia, Lymphoid                |                                                                          |      5  2.8|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  M  +  +  I  M  M  M  M                                             |  18        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Macrophage              | 1                                                                        |      1  1.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | M  +  +  +  +  +  +  +  +  +                                             |  57        |
      Atrophy                              |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |             2                                                            |     11  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      8  2.1|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  +                                             |  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Degeneration                         |    3        4        2  3                                                |     12  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |   2        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Parakeratosis                        |                                                                          |      1  1.0|
      Prepuce, Inflammation                |    4                                                                     |      9  3.9|
      Tail, Hyperkeratosis                 |                                                                          |      1  3.0|
      Tail, Inflammation                   |    2                                                                     |      1  2.0|
      Tail, Necrosis                       |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Developmental Malformation           |                                                                          |      1     |
      Hyperostosis                         |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 7| 7| 3| 1| 7|                                            |            |
                             DAY ON TEST   | 9| 3| 4| 4| 3| 4| 4| 5| 6| 3|                                            |            |
                                           | 2| 1| 1| 1| 7| 0| 1| 5| 3| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0.6MG/M3                               | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
                                           | 8| 9| 1| 2| 3| 4| 6| 7| 8| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cerebellum, White Matter,            |                                                                          |            |
          Degeneration, Focal              |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Fibrosis                             |                1                                                         |      3  1.0|
      Infiltration Cellular                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         | 1  2  3  1     3  1  1     1                                             |     52  1.7|
      Alveolar Epithelium, Hyperplasia     | 1     2  3  2  1  2  1     2                                             |     53  1.8|
      Alveolus, Hyperplasia, Macrophage    | 3  2  3  3  2  2  3  1  1  2                                             |     57  2.2|
      Alveolus, Proteinosis                | 4  2  4  3  2  2  3  3  1  3                                             |     57  2.9|
      Bronchus, Hyperplasia, Lymphoid      |       1  1  1  1  1                                                      |     29  1.1|
      Interstitium, Infiltration Cellular  | 1  1  2  3  2  3  2  1     2                                             |     54  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Olfactory Epithelium, Atrophy        | 1                          1                                             |     26  1.1|
      Olfactory Epithelium, Degeneration   |       1                                                                  |      8  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hydronephrosis                       |                                                                          |      5  2.0|
      Infiltration Cellular, Lymphocyte    |                                                                          |      3  2.0|
      Inflammation                         |                                                                          |      1  3.0|
      Nephropathy                          |             2                                                            |     10  1.3|
      Cortex, Atrophy                      |                                                                          |      2  3.0|
      Pelvis, Inflammation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 | +  +                                                                     |   7        |
      Concretion                           | 3  3                                                                     |      6  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Calculus Gross Observation           |                      X                                                   |      2     |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1| 4| 1| 4| 1| 1| 0| 4| 1| 1|              |            |
                             DAY ON TEST   | 7| 7| 9| 9| 7| 9| 9| 7| 7| 7| 9| 7| 9| 7| 9| 9| 3| 7| 9| 9|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.6MG/M3                               | 6| 6| 6| 7| 7| 7| 7| 8| 9| 9| 9| 0| 0| 0| 1| 1| 2| 3| 3| 3|              |      L     |
    LUNG TOX                               | 1| 5| 7| 2| 4| 5| 9| 7| 2| 3| 8| 2| 3| 8| 3| 5| 3| 0| 5| 9|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +        +           +  +                    A                        |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M        +           +  +                    A                        |   4        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +        +           +  +                    A                        |   5        |
      Hyperplasia, Focal, Lymphoid         |                         4                                                |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +        +           +  +                    A                        |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +        +           +  +                    A                        |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +        +           +  +                    A                        |   5        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +        +           +  +                    +                        |   6        |
      Degeneration                         |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +        +           +  +                    +                        |   6        |
      Hyperplasia, Focal                   | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +        +           +  +                    +                        |   6        |
      Hyperplasia, Focal                   | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +        +           +  +                    +                        |   6        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +        +           M  +                    M                        |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +        +           +  +                    +                        |   6        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +        +           +  +                    M                        |   5        |
      Ectasia                              | 4  1        4           1  3                                             |      5  2.6|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +        +           +  +                    +                        |   6        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1| 4| 1| 4| 1| 1| 0| 4| 1| 1|              |            |
                             DAY ON TEST   | 7| 7| 9| 9| 7| 9| 9| 7| 7| 7| 9| 7| 9| 7| 9| 9| 3| 7| 9| 9|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.6MG/M3                               | 6| 6| 6| 7| 7| 7| 7| 8| 9| 9| 9| 0| 0| 0| 1| 1| 2| 3| 3| 3|              |      L     |
    LUNG TOX                               | 1| 5| 7| 2| 4| 5| 9| 7| 2| 3| 8| 2| 3| 8| 3| 5| 3| 0| 5| 9|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +     +                                                |   2        |
      Inguinal, Hyperplasia, Lymphoid      |                         4                                                |      1  4.0|
      Lumbar, Hyperplasia, Lymphoid        |                   2                                                      |      1  2.0|
      Lumbar, Pigmentation                 |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  I  +     +  +  I     I  +        +           M     +                  |   7        |
      Hyperplasia, Lymphoid                | 1     1     2              2        1                                    |      5  1.4|
      Hyperplasia, Macrophage              | 1     1     1  1           2                                             |      5  1.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +        M           +  +                    +                        |   4        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  M  M     +  M  +     M  I        +           M     M                  |   3        |
      Hyperplasia                          |                                     1                                    |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +        +           +  +                    +                        |   6        |
      Hematopoietic Cell Proliferation     |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +        +           M  +                    +                        |   5        |
      Degeneration                         |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M        M           M  M                    M                        |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +        +           +  +                    +                        |   6        |
      Ulcer                                |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +        +           +  +                    +                        |   6        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +        +           +  +                    +                        |   6        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                            +                                             |   1        |
      Degeneration, Secondary Wallerian    |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +        I           +  +                    +                        |   5        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +     +  +        +           +     +                  |  11        |
      Inflammation, Chronic Active         | 2  1  2     1  1        1  1        1                                    |      8  1.3|
      Alveolar Epithelium, Hyperplasia     | 1           2           1  2                                             |      4  1.5|
      Alveolus, Hyperplasia, Macrophage    | 1  2  1     2  1  1     1  1        1                 1                  |     10  1.2|
      Alveolus, Proteinosis                | 4  3  1     4  1  1     3  3        1                 1                  |     10  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1| 4| 1| 4| 1| 1| 0| 4| 1| 1|              |            |
                             DAY ON TEST   | 7| 7| 9| 9| 7| 9| 9| 7| 7| 7| 9| 7| 9| 7| 9| 9| 3| 7| 9| 9|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    0.6MG/M3                               | 6| 6| 6| 7| 7| 7| 7| 8| 9| 9| 9| 0| 0| 0| 1| 1| 2| 3| 3| 3|              |      L     |
    LUNG TOX                               | 1| 5| 7| 2| 4| 5| 9| 7| 2| 3| 8| 2| 3| 8| 3| 5| 3| 0| 5| 9|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Bronchus, Hyperplasia, Lymphoid      |                         1                                                |      1  1.0|
      Interstitium, Infiltration Cellular  | 1  2  1     3  1  1     1  1        1                 1                  |     10  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     +  +  +     +  +        +           +     +                  |  11        |
      Olfactory Epithelium, Atrophy        | 1  1              1     1  1                                             |      5  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +        +           +  +                    +                        |   6        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +  +  +     +  +        +           +     +                  |  11        |
      Hydronephrosis                       |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                 +                        |   1        |
      Concretion                           |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +        +           +  +                    +     +                  |   7        |
      Calculus Micro Observation Only      |                                                       X                  |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 4| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 7| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 7| 3|             
                                           | 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  A  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +     +  M  M  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  A  +  +  +  +  +     +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  A  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +     +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                               3                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Angiectasis                          |                                                    3                     |             
      Atrophy                              |                            3                                             |             
      Basophilic Focus                     |                            X                                             |             
      Infarct                              |             4                                            4               |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                         3                                                |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Sinusoid, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  A  +  +  +  +  +  +  +  +     +|             
      Degeneration                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
      Developmental Malformation           |                            X                                             |             
      Inflammation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  M  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Focal                   |                                                                   2     1|             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  M  +  +  +  +  +  +  +  +  +     +  M  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +     +  +  I  +  +  +  +  +  +  +  +     +|             
      Pars Distalis, Hyperplasia           |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Follicular Cell, Hyperplasia         |          2        1  1                 1  1  1  1     2  1     1  1     1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 4| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 7| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 7| 3|             
                                           | 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Penis                                   |                         +              +                 +               |             
      Concretion                           |                                                                          |             
      Inflammation                         |                                        3                 2               |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Atrophy                              |                                                                          |             
      Ectasia                              | 1  3  3        3  3     3     3        3  4  3  3  3  2  4  2  2  3     2|             
      Inflammation, Chronic                |                      4                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Inflammation                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Atrophy                              |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Thrombosis                           |                                                                3         |             
      Erythroid Cell, Hyperplasia          |                                                       3                  |             
      Myeloid Cell, Hyperplasia            |    3              3                 3           3        3  2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                         +                                +  +            |             
      Iliac, Hyperplasia, Lymphoid         |                                                             3            |             
      Iliac, Hyperplasia, Plasma Cell      |                                                          3               |             
      Iliac, Pigmentation                  |                                                          2               |             
      Inguinal, Hyperplasia, Lymphoid      |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | I  I  M  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Lymphoid                |          2  2  2  4     2  1  4     2  1  1  2  2  1     2  3  2  1     3|             
      Hyperplasia, Macrophage              |          2  2  1  2  2  1     2     2  2  2  2  2  1  1  2  2  2  1     2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia, Lymphoid                |                            3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  M  +  +  +  +  +  +     +|             
      Hyperplasia, Lymphoid                |       4  4                    3                       3                 2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | I  M  M  M  I  +  M  I  +  I  I     +  +  +  +  +  M  I  +  M  I  M     M|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           3           4                  |             
      Hyperplasia, Lymphoid                |                      1                             2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 4| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 7| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 7| 3|             
                                           | 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  M  M  I  +  +  M  M  M     +  M  +  +  M  I  M  +  +  +  +     +|             
      Degeneration                         |    4                                      3              2               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M     M  M  M  M  M  M  M  M  M  M  M     M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Alopecia                             |                            2                                             |             
      Inflammation                         |    4                                                                     |             
      Prepuce, Hyperkeratosis              |                                                                          |             
      Prepuce, Inflammation                |          4              4                       4           4            |             
      Tail, Inflammation                   |                                     4                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Autolysis                            |                                           3                              |             
      Fibrosis                             |                1     1                                                  1|             
      Inflammation, Acute                  |       1                                                           1      |             
      Inflammation, Chronic Active         | 1  2  3  3  2  2  2  2  2     3     2        2  1  3  1  3  2  1  1     1|             
      Alveolar Epithelium, Hyperplasia     | 2  2  2  3  2  2  2  2  3     2     2  2  1  2  3     2  2  1  3  3     3|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Squamous                        |                      1                                                   |             
      Alveolus, Hyperplasia, Macrophage    | 2  2  2  4  3  3  4  3  3  1  3     3  2  2  2  2  2  3  2  2  2  3     2|             
      Alveolus, Hyperplasia                |                                           2                              |             
      Alveolus, Proteinosis                | 3  3  4  1  2  4  1  4  2  1  1     3  4  2  3  4  3  3  4  3  4  3     4|             
      Bronchus, Hyperplasia, Lymphoid      |          3        2           2                 2        1               |             
      Interstitium, Infiltration Cellular  | 1  1  1  3  3  2  3  2  1     4     1  1  1  1  2  1  2  1  1  2  2     2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute                  |                         1                                                |             
      Olfactory Epithelium, Atrophy        | 1  1  1  1  1  1  1  1        2     2  1  2  1  1  1  1  1  1  1  1     1|             
      Olfactory Epithelium, Degeneration   |                   1  1                                         1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 4| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 4| 7|             
                             DAY ON TEST   | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 7| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 7| 3|             
                                           | 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 6| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|             
                                           | 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Hydronephrosis                       |    2                                         3     3                     |             
      Infiltration Cellular, Lymphocyte    |                1                                                         |             
      Inflammation                         |                                                                          |             
      Nephropathy                          |                                                             1            |             
      Cortex, Fibrosis                     |                                                                          |             
      Pelvis, Inflammation                 |                                                          3               |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 | +  +                                   +  +     +        +               |             
      Calculus Micro Observation Only      | X                                                                        |             
      Concretion                           |                                        3  3     3        3               |             
      Inflammation                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +     +|             
      Calculus Micro Observation Only      |                                           X                              |             
      Inflammation                         |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 0| 4| 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3|             
                                           | 7| 0| 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  A  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Tissue, Hyperplasia,        |                                                                          |             
          Lymphoid                         |    3                             4                       3               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Peyer's Patch, Hyperplasia, Lymphoid |                3                 3                                       |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Infarct                              |                                                                          |             
      Mixed Cell Focus                     |                X                                                         |             
      Necrosis                             |                      3                 2  1                              |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Sinusoid, Cyst                       |                                                                   X      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                    3                     |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
      Developmental Malformation           |                                                                          |             
      Inflammation                         |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                3         |             
                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  M  +  M  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 1     1     1  1        1                             1              2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 0| 4| 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3|             
                                           | 7| 0| 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM - cont                |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |       +                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   | +        +  +           +                                                |             
      Concretion                           |          4                                                               |             
      Inflammation                         | 4           4           2                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                                                  |             
      Ectasia                              | 3  2        2  3  2     3        2  3  3  3  2              3  3  3  2  3|             
      Inflammation, Chronic                |                            2  3                    3  3                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation                         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |          A                                                               |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                          |             
      Erythroid Cell, Hyperplasia          |                                                                          |             
      Myeloid Cell, Hyperplasia            | 2           3     3           2     3                 3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +        +     +  +  +              +                           |             
      Iliac, Hyperplasia, Lymphoid         |                   4        3                                             |             
      Iliac, Hyperplasia, Plasma Cell      |                               3              3                           |             
      Iliac, Pigmentation                  |                                                                          |             
      Inguinal, Hyperplasia, Lymphoid      |          3        2     3     4                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1  4  3  3  1  4  3     1  4  1  3  1  1  1  2  3        4  3  4  3  2  2|             
      Hyperplasia, Macrophage              | 2  2  2  2  2  1  2  2  2  3  2  1  2  2  2  1  1        1  1  2  2  2  3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  A  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  M  M  M  M  I  A  M  M  +  M  I  +  M  +  M  I  M  I  +  +  +  +  I  +|             
      Hyperplasia, Lymphoid                |                                           3                              |             
      Hyperplasia, Macrophage              |                                                                         1|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |             2                                                        2   |             
      Hyperplasia, Lymphoid                |                   2           2                          2  1            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 0| 4| 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3|             
                                           | 7| 0| 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  I  +  +  +  +  +  +  +  +|             
      Degeneration                         | 2  3  3  3  2  2        3              3           3                 2  3|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alopecia                             |                                                                          |             
      Inflammation                         |                   4                                                      |             
      Prepuce, Hyperkeratosis              |                                                                      3   |             
      Prepuce, Inflammation                | 3        3              4  4        4     4  3                          4|             
      Tail, Inflammation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Fibrosis                             |    1           1                 1              1           1  1  1      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 2  3  1     1  3  2  1  2  2  1  3  1  1  2  2  2     2  3  2  3  2  2  2|             
      Alveolar Epithelium, Hyperplasia     | 2  2  3     2  1  2  2  2  3  1  2  2  2  2  2  3  2  2  2  2  2  2  2  2|             
      Alveolar Epithelium, Metaplasia,     |                                                                          |             
           Squamous                        |                                                                          |             
      Alveolus, Hyperplasia, Macrophage    | 2  3  2     2  3  2  3  2  3  2  3  2  3  2  2  3  2  2  4  4  3  3  2  3|             
      Alveolus, Hyperplasia                |                                                                          |             
      Alveolus, Proteinosis                | 3  3  3     3  2  4  4  3  2  4  1  2  3  4  4  3  2  4  2  3  3  3  3  3|             
      Bronchus, Hyperplasia, Lymphoid      |    3           2           2        1        1           1           1   |             
      Interstitium, Infiltration Cellular  | 1  2  2     1  4  1  1  2  2  1  3  2  2  2  1  3     1  3  3  2  2  1  1|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Olfactory Epithelium, Atrophy        | 1  2  2  1  2  2  1  1  2  2  1  1  1  1  1  1  1  1  2  1  1  1  1  1  2|             
      Olfactory Epithelium, Degeneration   |                               1                                   1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 0| 4| 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3|             
                                           | 7| 0| 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1.2MG/M3                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       |                   1                                                  2   |             
      Infiltration Cellular, Lymphocyte    |                            2                                             |             
      Inflammation                         |                               3                                          |             
      Nephropathy                          | 1           1  1                                                     1   |             
      Cortex, Fibrosis                     |                                                                          |             
      Pelvis, Inflammation                 | 3                                                                        |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Necrosis               |                         2                                                |             
                                            __________________________________________________________________________|             
   Urethra                                 | +           +                       +                                +   |             
      Calculus Micro Observation Only      |                                                                          |             
      Concretion                           | 3           3                       3                                3   |             
      Inflammation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation                         | 4                                   2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 5| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 4| 1| 3| 3| 4| 7| 3|                                            |            |
                                           | 7| 5| 7| 0| 3| 9| 7| 0| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    1.2MG/M3                               | 8| 8| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 7| 9| 1| 3| 4| 5| 6| 7| 8| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  A  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  +  +  +  +  A  M                                             |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  A  +                                             |  54        |
      Lymphoid Tissue, Hyperplasia,        |                                                                          |            |
          Lymphoid                         |                                                                          |      3  3.3|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +                                             |  54        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  A  +                                             |  57        |
      Angiectasis                          |                                                                          |      1  3.0|
      Atrophy                              |    3                                                                     |      2  3.0|
      Basophilic Focus                     |                                                                          |      1     |
      Infarct                              |                                                                          |      2  4.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             | 3                                                                        |      5  2.4|
      Pigmentation, Hemosiderin            |             3                                                            |      1  3.0|
      Sinusoid, Cyst                       |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  A  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  A  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  A  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +                                             |  55        |
      Degeneration                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |       +  +                                                               |   4        |
      Developmental Malformation           |       X                                                                  |      2     |
      Inflammation                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  A  +                                             |  56        |
      Hyperplasia, Focal                   |             2                                                            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  A  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  A  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  A  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 5| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 4| 1| 3| 3| 4| 7| 3|                                            |            |
                                           | 7| 5| 7| 0| 3| 9| 7| 0| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    1.2MG/M3                               | 8| 8| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 7| 9| 1| 3| 4| 5| 6| 7| 8| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  A  M                                             |  53        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  A  +                                             |  57        |
      Follicular Cell, Hyperplasia         | 1     2        1  1        1                                             |     24  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |             +                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  A  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                +                                                         |   8        |
      Concretion                           |                                                                          |      1  4.0|
      Inflammation                         |                4                                                         |      6  3.2|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      1  2.0|
      Ectasia                              | 4  3  3     2     2     3  2                                             |     41  2.7|
      Inflammation, Chronic                |          3     3                                                         |      7  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  A  +                                             |  57        |
      Inflammation                         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  A  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  A  +                                             |  57        |
      Atrophy                              |             3                                                            |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  A  +                                             |  57        |
      Thrombosis                           |                                                                          |      1  3.0|
      Erythroid Cell, Hyperplasia          |                                                                          |      1  3.0|
      Myeloid Cell, Hyperplasia            |       2        3                                                         |     14  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                +                                                         |  10        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      3  3.3|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      3  3.0|
      Iliac, Pigmentation                  |                                                                          |      1  2.0|
      Inguinal, Hyperplasia, Lymphoid      |                4                                                         |      6  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  A  +                                             |  53        |
      Hyperplasia, Lymphoid                | 1  1  1  3  2  2  2  4     2                                             |     49  2.2|
      Hyperplasia, Macrophage              | 2  2  2  2     2  2        2                                             |     49  1.8|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  A  +                                             |  55        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 5| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 4| 1| 3| 3| 4| 7| 3|                                            |            |
                                           | 7| 5| 7| 0| 3| 9| 7| 0| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    1.2MG/M3                               | 8| 8| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 7| 9| 1| 3| 4| 5| 6| 7| 8| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  A  +                                             |  53        |
      Hyperplasia, Lymphoid                |                            3                                             |      6  3.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | I  M  I  I  M  +  I  I  A  M                                             |  17        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia, Macrophage              |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  A  +                                             |  55        |
      Atrophy                              |    3                                                                     |      1  3.0|
      Hematopoietic Cell Proliferation     |             3                                                            |      5  2.8|
      Hyperplasia, Lymphoid                |          2                                                               |      7  1.7|
      Inflammation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +  +  +  M  +  +  A  +                                             |  39        |
      Degeneration                         |             3                                                            |     15  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M                                             |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  A  +                                             |  57        |
      Alopecia                             |                                                                          |      1  2.0|
      Inflammation                         |                                                                          |      2  4.0|
      Prepuce, Hyperkeratosis              |                                                                          |      1  3.0|
      Prepuce, Inflammation                |                4                                                         |     13  3.8|
      Tail, Inflammation                   |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  A  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  A  +                                             |  57        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  A  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  A  +                                             |  56        |
      Autolysis                            |                                                                          |      1  3.0|
      Fibrosis                             | 1     1  1        1  1                                                   |     15  1.0|
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Inflammation, Chronic Active         | 2  2  2  2  3  2  2  3     1                                             |     52  2.0|
      Alveolar Epithelium, Hyperplasia     | 3  2  2  2  2  2  2  3     3                                             |     54  2.1|
      Alveolar Epithelium, Metaplasia,     |                                                                          |            |
           Squamous                        |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 3| 7| 7| 7| 5| 7| 7| 6| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 4| 1| 3| 3| 4| 7| 3|                                            |            |
                                           | 7| 5| 7| 0| 3| 9| 7| 0| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      A     |
    1.2MG/M3                               | 8| 8| 9| 9| 9| 9| 9| 9| 9| 0|                                            |      L     |
                                           | 7| 9| 1| 3| 4| 5| 6| 7| 8| 0|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Hyperplasia, Macrophage    | 4  1  3  4  3  2  3  3     2                                             |     56  2.6|
      Alveolus, Hyperplasia                |                                                                          |      1  2.0|
      Alveolus, Proteinosis                | 3  4  3  3  2  3  4  3     4                                             |     56  3.0|
      Bronchus, Hyperplasia, Lymphoid      |       1              1                                                   |     14  1.6|
      Interstitium, Infiltration Cellular  | 2     3  2  2  2  2  2     2                                             |     53  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  A  +                                             |  57        |
      Foreign Body                         |    2                                                                     |      1  2.0|
      Inflammation, Acute                  | 2        3                                                               |      3  2.0|
      Olfactory Epithelium, Atrophy        | 1  1  1  2  1     1  1     1                                             |     54  1.2|
      Olfactory Epithelium, Degeneration   |                   1                                                      |      6  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  M  +  +  M  +                                             |  56        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  A  +                                             |  57        |
      Hydronephrosis                       |                                                                          |      5  2.2|
      Infiltration Cellular, Lymphocyte    |                                                                          |      2  1.5|
      Inflammation                         |                                                                          |      1  3.0|
      Nephropathy                          |             1                                                            |      6  1.0|
      Cortex, Fibrosis                     |             2                                                            |      1  2.0|
      Pelvis, Inflammation                 |                                                                          |      2  3.0|
      Renal Tubule, Atrophy                |             4                                                            |      1  4.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |    +                                                                     |  11        |
      Calculus Micro Observation Only      |    X                                                                     |      2     |
      Concretion                           |                                                                          |      8  3.0|
      Inflammation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +                                             |  56        |
      Calculus Micro Observation Only      |    X                                                                     |      2     |
      Inflammation                         |                                                                          |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 4| 1| 4| 4| 1| 1| 3| 4| 1| 4| 1| 1| 1| 4| 1| 4| 1| 1|              |            |
                             DAY ON TEST   | 9| 7| 7| 9| 7| 7| 9| 9| 9| 7| 9| 7| 9| 9| 9| 7| 9| 7| 9| 1|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    1.2MG/M3                               | 2| 2| 3| 3| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|              |      L     |
    LUNG TOX                               | 1| 6| 2| 8| 1| 4| 5| 7| 8| 0| 4| 7| 9| 3| 5| 7| 8| 0| 2| 9|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                +        A  +     +           +     M     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                M        M  +     +           +     +     +               |   5        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                +        A  +     +           +     +     +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                +        A  +     +           +     +     +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                +        A  +     +           +     +     +               |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                +        A  +     +           +     +     +               |   6        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                +        +  +     +           +     +     +               |   7        |
      Basophilic Focus                     |                            X                                             |      1     |
      Mixed Cell Focus                     |                X                                                         |      1     |
      Necrosis                             |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                +        +  +     +           +     +     +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                +        +  +     +           +     +     +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                M        +  M     +           +     M     M               |   3        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                +        +  +     +           +     +     +               |   7        |
      Follicular Cell, Hyperplasia         |                                  2                                       |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                +        +  +     +           +     +     +               |   7        |
      Ectasia                              |                         2  2     4                 1                     |      4  2.3|
      Inflammation, Chronic                |                                              2                           |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                +        +  +     +           +     +     +               |   7        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 4| 1| 4| 4| 1| 1| 3| 4| 1| 4| 1| 1| 1| 4| 1| 4| 1| 1|              |            |
                             DAY ON TEST   | 9| 7| 7| 9| 7| 7| 9| 9| 9| 7| 9| 7| 9| 9| 9| 7| 9| 7| 9| 1|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    1.2MG/M3                               | 2| 2| 3| 3| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|              |      L     |
    LUNG TOX                               | 1| 6| 2| 8| 1| 4| 5| 7| 8| 0| 4| 7| 9| 3| 5| 7| 8| 0| 2| 9|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  |                +        +  +     +           +     +     +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                +        +  +     +           +     +     +               |   7        |
      Myeloid Cell, Hyperplasia            |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                         +                                                |   1        |
      Inguinal, Pigmentation               |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +              +        +  +     +  +  +     +  +  +  +  M               |  11        |
      Hyperplasia, Lymphoid                | 1              2           2     1           4  1  2  1                  |      8  1.8|
      Hyperplasia, Macrophage              | 1              1        2        1  1  1     2  1  1  1                  |     10  1.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                +        M  +     +           M     +  +  +               |   6        |
      Hyperplasia, Lymphoid                |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +        +  +     +           +     +     +               |   7        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +              M        A  M     +  +  I     I  M  +  +  M               |   5        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |                +        +  +     +           +     +     +               |   7        |
      Hyperplasia, Lymphoid                |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                +        +  +     +           +     +     +               |   7        |
      Degeneration                         |                         4                                                |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                M        M  M     M           M     M     M               |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                +        +  +     +           +     +     +               |   7        |
      Subcutaneous Tissue, Abscess         |                                              4                           |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                +        +  +     +           +     +     +               |   7        |
      Femur, Hyperostosis                  |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                +        +  +     +           +     +     +               |   7        |
      Medulla, Degeneration, Focal         |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                          +               |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Larynx                                  |                +        +  +     +           +     I     +               |   6        |
                                            __________________________________________________________________________|____________|
   Lung                                    | +              +        +  +     +  +  +     +  +  +  +  +               |  12        |
      Fibrosis                             |                                                          1               |      1  1.0|
      Inflammation, Chronic Active         | 2              2           2     2  2  2     2  1  1  1  2               |     11  1.7|
      Alveolar Epithelium, Hyperplasia     |                2           2     3           3     3                     |      5  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05107-06                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                         NICKEL SUBSULFIDE                                     Date: 04/18/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 12:19:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 4| 1| 4| 4| 1| 1| 3| 4| 1| 4| 1| 1| 1| 4| 1| 4| 1| 1|              |            |
                             DAY ON TEST   | 9| 7| 7| 9| 7| 7| 9| 9| 9| 7| 9| 7| 9| 9| 9| 7| 9| 7| 9| 1|              |            |
                                           | 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|              |      A     |
    1.2MG/M3                               | 2| 2| 3| 3| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9|              |      L     |
    LUNG TOX                               | 1| 6| 2| 8| 1| 4| 5| 7| 8| 0| 4| 7| 9| 3| 5| 7| 8| 0| 2| 9|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolus, Hyperplasia, Macrophage    | 1              1        2  2     3  2  2     3  1  2  1  1               |     12  1.8|
      Alveolus, Proteinosis                | 2              2        3  3     4  2  2     3  1  3  1                  |     11  2.4|
      Bronchus, Hyperplasia, Lymphoid      |                1           1                                             |      2  1.0|
      Interstitium, Infiltration Cellular  | 1              2        1  1     1     1     2     1  1  1               |     10  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +              +        +  +     +  +  +     +  +  +  +  +               |  12        |
      Olfactory Epithelium, Atrophy        | 1              1        1  1     1  1           1  1  1                  |      9  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                +        +  +     +           +     +     +               |   7        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +              +        +  +     +  +  +     +  +  +  +  +               |  12        |
      Inflammation                         |                         4                                                |      1  4.0|
      Nephropathy                          |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                              +                           |   1        |
      Calculus Micro Observation Only      |                                              X                           |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                +        +  +     +           +     +     +               |   7        |
      Calculus Gross Observation           |                         X                                                |      1     |
      Inflammation                         |                         2                                                |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.