TDMS Study 05107-06 Pathology Tables
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
Facility: Lovelace Inhalation Toxicology Research Institute
Chemical CAS #: 12035722
Lock Date: 10/14/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 6| 7| 6|
DAY ON TEST | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 1| 8| 3| 9|
| 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 7| 4| 3| 6| 9| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + + + + +|
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 2 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + A + + +|
Atrophy | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + A + + +|
Atrophy | 3 |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + +|
Atrophy | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Cyst | |
Degeneration | |
Fibrosis | |
Infarct | 4 |
Infiltration Cellular, Lymphocyte | 3 2 |
Inflammation | 4 |
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Necrosis | |
Artery, Inflammation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 3 |
Infiltration Cellular, Lymphocyte | 2 |
Acinus, Atrophy | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Squamous | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Tooth | + |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Artery, Inflammation | |
Atrium, Thrombosis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 6| 7| 6|
DAY ON TEST | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 1| 8| 3| 9|
| 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 7| 4| 3| 6| 9| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + M + + M + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Cyst | X |
Pars Distalis, Hyperplasia | 2 2 4 4 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | |
Follicle, Atrophy | |
Follicular Cell, Hyperplasia | 1 2 1 1 1 4 2 2 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | M + + + + + + + + + + + + + + + + + + M + + + M|
Ectasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Angiectasis | 4 |
Cyst | X X X X|
Endometrium, Hyperplasia | 2 2 4 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 3 |
Myeloid Cell, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Inflammation | 4 |
Pancreatic, Inflammation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + M + + + + + + + + + + + + + + + + + + + I +|
Hyperplasia, Lymphoid | 1 2 1 3 2 1 2 |
Inflammation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 2 3 3 3 4 2 2 4|
Hyperplasia, Plasma Cell | 3 |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 6| 7| 6|
DAY ON TEST | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 1| 8| 3| 9|
| 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 7| 4| 3| 6| 9| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + +|
Ectasia | |
Hyperplasia, Lymphoid | 2 2 |
Inflammation | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M + M + M M M M I M M + M M + + I + + M M +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 4 3 3 3 3 4 2 2 4 2 3|
Hyperplasia, Lymphoid | 3 3 4 2 3 2 2 3 |
Inflammation | 4 |
Lymphoid Follicle, Atrophy | |
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 3 2 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + M + + +|
Hyperplasia, Cystic | |
Hyperplasia | 2 2 2 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Inflammation | 2 4|
Pinna, Inflammation | 4 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Inflammation | 2 |
Femur, Hyperostosis | X X X|
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | + |
Degeneration | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + I + + M + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | |
Alveolus, Hyperplasia, Macrophage | 2 |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 4| 6| 7| 6|
DAY ON TEST | 9| 3| 3| 4| 3| 9| 3| 9| 3| 2| 3| 3| 3| 3| 3| 3| 4| 7| 3| 3| 3| 1| 8| 3| 9|
| 8| 6| 3| 5| 4| 4| 5| 1| 6| 7| 3| 5| 5| 4| 3| 6| 9| 7| 4| 3| 6| 9| 3| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1|
| 1| 3| 4| 5| 6| 7| 8| 9| 1| 3| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Bronchus, Hyperplasia, Lymphoid | 1 2 1 2 2 2 1 2 2 2 2 2 2 2 2 2 1|
Interstitium, Infiltration Cellular | 1 1 1 1 2 2 1 2 |
Interstitium, Inflammation | 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 1 1 1 1 1 1 |
Respiratory Epithelium, Degeneration | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + M|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation | 3 |
External Ear, Inflammation | |
__________________________________________________________________________|
Eye | +|
Cataract | 3|
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | 3 |
Infiltration Cellular, Lymphocyte | 2 2 2 2 2 |
Inflammation | 4 |
Nephropathy | 1 2 3 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + I +|
Infiltration Cellular, Lymphocyte | 3 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7|
DAY ON TEST | 7| 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3|
| 9| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 4| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A A + + + + + + A + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + A + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + M + + M + + + + + + + + A + + M + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A A + + + + + + A + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A A + + + + + + A + +|
Atrophy | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A A + + + + + + A + +|
Atrophy | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A A + + + + + + A + +|
Atrophy | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Cyst | |
Degeneration | 4 |
Fibrosis | 2 |
Infarct | |
Infiltration Cellular, Lymphocyte | |
Inflammation | 1 2 1 |
Necrosis | 3 |
__________________________________________________________________________|
Mesentery | + |
Necrosis | 4 |
Artery, Inflammation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 4 |
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + A + +|
Hyperplasia, Squamous | 2 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + A + +|
Inflammation | 2 |
__________________________________________________________________________|
Tooth | + |
Inflammation | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Artery, Inflammation | |
Atrium, Thrombosis | X X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 6
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7|
DAY ON TEST | 7| 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3|
| 9| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 4| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + M + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 2 |
Cyst | |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Artery, Inflammation | |
Follicle, Atrophy | |
Follicular Cell, Hyperplasia | 2 1 2 3 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ectasia | 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X X X X|
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Angiectasis | |
Cyst | |
Endometrium, Hyperplasia | 2 2 2 2 2 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + M + + + + + + + +|
Inflammation | |
Myeloid Cell, Hyperplasia | 3 |
__________________________________________________________________________|
Lymph Node | + + + + |
Inguinal, Hyperplasia, Lymphoid | |
Inguinal, Inflammation | |
Pancreatic, Inflammation | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + I I + + + + M + + + + + I + + + + + I + + + +|
Hyperplasia, Lymphoid | 2 3 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +|
Hyperplasia, Lymphoid | 3 2 2 3 3 4|
Hyperplasia, Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 7
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7|
DAY ON TEST | 7| 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3|
| 9| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 4| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + M + + + +|
Ectasia | 4 |
Hyperplasia, Lymphoid | 2 |
Inflammation | 4 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + I M M M M M M + M M M + + M M M + + M M + M M M|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 4 |
Hyperplasia, Lymphoid | 2 2 2 2 2|
Inflammation | |
Lymphoid Follicle, Atrophy | 3 2 |
Red Pulp, Atrophy | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 4 4 3 3 |
Hyperplasia | |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Cystic | 2 |
Hyperplasia | 2 3 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Inflammation | 4 |
Pinna, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + M + + + + + + + +|
Hyperostosis | X |
Inflammation | |
Femur, Hyperostosis | X X X X |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
Degeneration | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + I +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 2 |
Alveolar Epithelium, Hyperplasia | 4 2 1 |
Alveolus, Hyperplasia, Macrophage | 1 4 |
_____________________________________________________________________________________________________________________|
Page 8
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 7| 3| 5| 5| 5| 7|
DAY ON TEST | 7| 3| 3| 3| 2| 3| 0| 3| 3| 7| 3| 3| 3| 3| 8| 8| 3| 3| 3| 3| 0| 5| 0| 3| 3|
| 9| 4| 5| 4| 3| 5| 3| 3| 4| 4| 6| 3| 5| 3| 8| 0| 6| 4| 5| 4| 0| 2| 8| 6| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.0MG/M3 | 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|
| 4| 5| 6| 7| 8| 9| 0| 1| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 8| 1| 2| 4| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Bronchus, Hyperplasia, Lymphoid | 1 1 2 3 2 1 1 1 1 1 1|
Interstitium, Infiltration Cellular | 1 1 1 1 1 1 1 1 |
Interstitium, Inflammation | |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 1 |
Olfactory Epithelium, Degeneration | 1 1 1 2 1 1 1 1 1 1 1|
Respiratory Epithelium, Degeneration | 3 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
Inflammation | |
External Ear, Inflammation | 3 |
__________________________________________________________________________|
Eye | |
Cataract | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infarct | |
Infiltration Cellular, Lymphocyte | 2 2 1 2|
Inflammation | |
Nephropathy | 2 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + A + +|
Infiltration Cellular, Lymphocyte | |
_____________________________________________________________________________________________________________________|
Page 9
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 3| 4| 7| 7| 7| | |
DAY ON TEST | 6| 3| 3| 0| 3| 8| 7| 3| 3| 3| | |
| 3| 3| 3| 0| 3| 5| 7| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Gallbladder | + + + + I + + + + | 53 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M M + M + + M + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + | 54 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + | 53 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + | 54 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + | 54 |
Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + | 58 |
Angiectasis | 2 | 3 2.7|
Cyst | X | 1 |
Degeneration | | 1 4.0|
Fibrosis | | 1 2.0|
Infarct | | 1 4.0|
Infiltration Cellular, Lymphocyte | | 2 2.5|
Inflammation | | 4 2.0|
Necrosis | | 2 3.0|
__________________________________________________________________________|____________|
Mesentery | + | 3 |
Necrosis | | 1 4.0|
Artery, Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + | 58 |
Atrophy, Focal | | 2 3.5|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Acinus, Atrophy | 2 | 2 3.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + | 57 |
Hyperplasia, Squamous | | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + | 57 |
Inflammation | 3 | 2 2.5|
__________________________________________________________________________|____________|
Tooth | | 2 |
Inflammation | | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 3| 4| 7| 7| 7| | |
DAY ON TEST | 6| 3| 3| 0| 3| 8| 7| 3| 3| 3| | |
| 3| 3| 3| 0| 3| 5| 7| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + | 58 |
Inflammation | | 1 3.0|
Artery, Inflammation | 3 | 1 3.0|
Atrium, Thrombosis | | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + | 58 |
Angiectasis | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + | 58 |
Angiectasis | | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + + M | 52 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + | 58 |
Angiectasis | | 2 2.0|
Cyst | | 1 |
Pars Distalis, Hyperplasia | 2 3 | 7 2.7|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + | 58 |
Artery, Inflammation | 2 | 1 2.0|
Follicle, Atrophy | 2 | 1 2.0|
Follicular Cell, Hyperplasia | 3 3 1 | 20 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + | 55 |
Ectasia | | 2 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + | 58 |
Cyst | X | 6 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + | 58 |
Abscess | | 1 3.0|
Angiectasis | | 1 4.0|
Cyst | X | 5 |
Endometrium, Hyperplasia | 2 2 | 14 2.2|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + | 57 |
Inflammation | | 1 3.0|
Myeloid Cell, Hyperplasia | 3 2 2 | 7 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 3| 4| 7| 7| 7| | |
DAY ON TEST | 6| 3| 3| 0| 3| 8| 7| 3| 3| 3| | |
| 3| 3| 3| 0| 3| 5| 7| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + | 9 |
Inguinal, Hyperplasia, Lymphoid | 3 | 1 3.0|
Inguinal, Inflammation | | 1 4.0|
Pancreatic, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + I + + + + + | 50 |
Hyperplasia, Lymphoid | 2 | 10 1.9|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + | 57 |
Hyperplasia, Lymphoid | 4 2 4 | 18 3.0|
Hyperplasia, Plasma Cell | 3 | 2 3.0|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + | 55 |
Ectasia | | 1 4.0|
Hyperplasia, Lymphoid | 2 | 4 2.0|
Inflammation | | 3 3.7|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M M M | 15 |
Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + | 58 |
Hematopoietic Cell Proliferation | | 14 2.9|
Hyperplasia, Lymphoid | 3 1 2 2 | 17 2.4|
Inflammation | | 1 4.0|
Lymphoid Follicle, Atrophy | | 2 2.5|
Red Pulp, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + | 58 |
Degeneration | | 8 3.1|
Hyperplasia | 3 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + | 57 |
Hyperplasia, Cystic | | 1 2.0|
Hyperplasia | 2 | 8 2.3|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + | 58 |
Fibrosis | | 1 3.0|
Inflammation | | 3 3.3|
Pinna, Inflammation | | 2 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + | 57 |
Hyperostosis | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 5| 7| 7| 6| 7| 3| 4| 7| 7| 7| | |
DAY ON TEST | 6| 3| 3| 0| 3| 8| 7| 3| 3| 3| | |
| 3| 3| 3| 0| 3| 5| 7| 6| 5| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 4| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
| 9| 1| 2| 3| 4| 5| 6| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
Inflammation | | 1 2.0|
Femur, Hyperostosis | X X X | 10 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Degeneration | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + M | 54 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + | 58 |
Inflammation, Chronic Active | | 1 2.0|
Alveolar Epithelium, Hyperplasia | | 3 2.3|
Alveolus, Hyperplasia, Macrophage | 1 1 | 5 1.8|
Bronchus, Hyperplasia, Lymphoid | 1 1 1 1 1 1 | 34 1.5|
Interstitium, Infiltration Cellular | 1 1 1 | 19 1.2|
Interstitium, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + | 58 |
Olfactory Epithelium, Atrophy | | 1 1.0|
Olfactory Epithelium, Degeneration | 1 1 1 1 | 26 1.0|
Respiratory Epithelium, Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
Inflammation | | 1 3.0|
External Ear, Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Eye | + | 2 |
Cataract | | 1 3.0|
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + | 58 |
Infarct | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 9 1.9|
Inflammation | | 1 4.0|
Nephropathy | | 5 1.8|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + | 56 |
Infiltration Cellular, Lymphocyte | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 4| 4| 4| 1| 1| 1| 4| 4| 1| 4| 4| 1| 0| 4| | |
DAY ON TEST | 6| 9| 9| 9| 9| 9| 7| 7| 7| 9| 9| 9| 7| 7| 9| 7| 7| 9| 6| 7| | |
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| | L |
LUNG TOX | 2| 0| 2| 4| 5| 7| 1| 3| 2| 3| 4| 5| 6| 3| 9| 0| 3| 5| 0| 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M + + + + | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
Hyperplasia, Lymphoid | 3 | 1 3.0|
Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
Basophilic Focus | X | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + + I | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M | 4 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 5 |
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + M + | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 5 |
Endometrium, Hyperplasia | 2 2 3 | 3 2.3|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 4| 4| 4| 1| 1| 1| 4| 4| 1| 4| 4| 1| 0| 4| | |
DAY ON TEST | 6| 9| 9| 9| 9| 9| 7| 7| 7| 9| 9| 9| 7| 7| 9| 7| 7| 9| 6| 7| | |
| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
0.0MG/M3 | 8| 9| 9| 9| 9| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 4| 4| 4| 5| 5| | L |
LUNG TOX | 2| 0| 2| 4| 5| 7| 1| 3| 2| 3| 4| 5| 6| 3| 9| 0| 3| 5| 0| 7| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + + + + | 7 |
Hyperplasia, Lymphoid | 1 2 3 2 | 4 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + M + + | 4 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Alveolus, Hyperplasia, Macrophage | 1 | 1 1.0|
Bronchus, Hyperplasia, Lymphoid | 1 2 2 1 | 4 1.5|
Interstitium, Infiltration Cellular | 1 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Olfactory Epithelium, Degeneration | 1 1 1 1 2 | 5 1.2|
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
External Ear, Ulcer | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|
| 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + A + + + M + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Rectum | M + M M + + + M + + + M + + + M + + + + + + A + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + + A + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + A + + + + + + + + + + + + + + A + +|
Inflammation | 4 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + A + + + + + + + + + + + + + + A + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + A + + + + + + + + + + + + + + A + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Atrophy | 2 3 |
Basophilic Focus | X |
Degeneration | |
Eosinophilic Focus | |
Infarct | |
Infiltration Cellular, Lymphocyte | |
Inflammation | |
Mixed Cell Focus | X |
Necrosis | 1 2 |
Pigmentation, Hemosiderin | 3 |
__________________________________________________________________________|
Mesentery | + + + |
Inflammation | 4 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation | 4 |
Acinus, Atrophy | 4 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation | 2 1 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 1 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + M + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 16
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|
| 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | 2 |
Atrophy | |
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 3 |
Pars Distalis, Hyperplasia | 2 2 4 3|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 2 1 1 2 1 1 2 1 1 1 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + + + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 1 |
Inflammation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X X X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X X |
Cyst, Multiple | |
Inflammation | |
Endometrium, Hyperplasia | 2 2 2 3 2 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | 3 |
Myeloid Cell, Atrophy | |
Myeloid Cell, Hyperplasia | 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hyperplasia, Lymphoid | |
Pancreatic, Inflammation | 3 |
Renal, Hyperplasia, Lymphoid | |
Renal, Inflammation, Granulomatous | |
Renal, Inflammation | 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 3 2 1 3 2 3 4 3 2 1 3 3 3 4 2 1 2 2|
_____________________________________________________________________________________________________________________|
Page 17
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|
| 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Macrophage | 1 2 2 1 2 2 2 1 1 2 2 2 1 1 1 1 3 2 1|
Inflammation, Granulomatous | |
Inflammation | 3 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + + + + + + + + M + + + + + + + +|
Hyperplasia, Lymphoid | 3 3|
Inflammation | 4 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + M + + M + I + M M M + M + M I + + + + I +|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 3 2 3 3 3 2 2 |
Hyperplasia, Lymphoid | 2 2 2 3 3 2 2 3 2 4|
Red Pulp, Atrophy | |
__________________________________________________________________________|
Thymus | + + + + + + M + + + + + + + + + + + + + + + + + +|
Degeneration | 3 3 3 |
Hyperplasia, Lymphoid | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | X X |
Tibia, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + M + I + + + + + + + + + + + +|
Inflammation | 1 |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bronchiectasis | 3 |
Fibrosis | 1 1 1 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 1 2 1 1 2 2 3 1 2 2 1 2 3 1 2 1 2 2|
Alveolar Epithelium, Hyperplasia | 2 2 2 2 2 1 2 2 1 1 1 2 1 2 1 3 2 2 3 2 2 1 2 2|
Alveolus, Hyperplasia, Macrophage | 3 3 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 3 3 3 3 3 3 2|
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 7| 5| 6| 4| 7| 7| 6| 6| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 5| 3| 3| 4| 0| 3| 3| 5| 3| 3| 5| 9| 2| 3| 3| 3| 3| 3| 3| 1| 3| 1|
| 4| 3| 6| 5| 4| 6| 2| 3| 4| 4| 2| 6| 5| 2| 2| 8| 3| 4| 4| 3| 6| 4| 2| 3| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7|
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 5| 6| 7| 8| 1| 2| 3| 4| 6| 7| 8| 9| 1| 2|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Proteinosis | 3 3 3 2 2 3 1 2 2 4 1 4 2 2 4 3 3 3 2 3 4 2 3 4|
Bronchus, Hyperplasia, Lymphoid | 2 2 3 2 1 1 2 1 1 4 1 1 2 3|
Interstitium, Infiltration Cellular | 3 4 2 1 3 1 1 3 2 2 3 2 2 1 1 3 2 3 1 2 3 4 3|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 4 1 1|
Olfactory Epithelium, Atrophy | 1 1 |
Olfactory Epithelium, Degeneration | 1 1|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Inflammation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 |
Infiltration Cellular, Lymphocyte | 1 2 2 2 |
Nephropathy | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + A + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 2 2 |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|
| 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
0.6MG/M3 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + A + + + + + + + + A + + M +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + A + + + + + + + + A + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 4 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + A + + + + + + + + A + + + +|
Inflammation | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + A + + + + + + + + A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + A + + + + + + + + A + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 3 |
Basophilic Focus | |
Degeneration | 2 |
Eosinophilic Focus | X |
Infarct | 4 4 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | 3 1|
Mixed Cell Focus | |
Necrosis | 3 |
Pigmentation, Hemosiderin | |
__________________________________________________________________________|
Mesentery | + |
Inflammation | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + A + + + +|
Cyst | |
Infiltration Cellular, Lymphocyte | |
Inflammation | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 1 1 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|
| 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
0.6MG/M3 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | |
Atrophy | 3 |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + A + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + M + M + + + I|
Angiectasis | 3 4 |
Pars Distalis, Hyperplasia | 3 3 4 3 3 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 2 1 2 1 2 2 2 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
Atrophy | |
Ectasia | |
Inflammation | 1 |
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Abscess | 4|
Cyst | X X X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4 |
Cyst | X |
Cyst, Multiple | X |
Inflammation | 1 |
Endometrium, Hyperplasia | 4 3 2 3 3 2 2 4 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | 3 |
Myeloid Cell, Atrophy | 3 |
Myeloid Cell, Hyperplasia | 3 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Hyperplasia, Lymphoid | 4 |
Pancreatic, Inflammation | |
Renal, Hyperplasia, Lymphoid | 4 4 |
Renal, Inflammation, Granulomatous | |
Renal, Inflammation | |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + M M|
Hyperplasia, Lymphoid | 3 1 2 3 2 1 2 3 2 2 2 3 2 2 2 2 1 1 2 |
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|
| 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
0.6MG/M3 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Macrophage | 1 1 1 1 1 1 1 1 2 1 3 2 2 2 1 2 1 |
Inflammation, Granulomatous | |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 3 3 3 1 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + A + + + + + + + + + + A + + + +|
Hyperplasia, Lymphoid | 2 3 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + M + + + M M + M + + I M M M + + I M M M + M|
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 4 3 3 3 3 2 |
Hyperplasia, Lymphoid | 3 2 3 2 2 4 2 2 2 2 3 2|
Red Pulp, Atrophy | 3 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + A + + + +|
Degeneration | 4 2 |
Hyperplasia, Lymphoid | 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 3 3 2 2 3 3 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Femur, Hyperostosis | X X X X X X |
Tibia, Fracture | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + I + + + + + + + + + + + + + + + + + I + + +|
Inflammation | |
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + A + + + +|
Bronchiectasis | |
Fibrosis | 1 1 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 1 2 3 1 3 2 3 1 2 1 3 1 1 1 1 2 2 2 2 |
Alveolar Epithelium, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 1 2 2 2 2 2 2 2 2 2 |
Alveolus, Hyperplasia, Macrophage | 3 3 3 3 2 4 4 2 3 3 1 2 4 3 3 3 2 3 3 4 2 1|
_____________________________________________________________________________________________________________________|
Page 22
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 4| 5| 7| 7| 7| 7| 6| 6| 7| 2| 7| 7| 5| 1|
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 5| 3| 5| 3| 2| 2| 3| 3| 3| 3| 5| 9| 3| 0| 3| 3| 3| 1|
| 5| 4| 3| 5| 5| 6| 3| 5| 5| 5| 6| 5| 0| 3| 6| 3| 4| 3| 4| 4| 6| 5| 6| 0| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3|
0.6MG/M3 | 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0|
| 3| 4| 5| 6| 7| 8| 0| 1| 3| 4| 5| 1| 3| 5| 6| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Alveolus, Proteinosis | 1 2 4 3 3 4 2 4 3 3 1 4 2 4 2 3 3 3 3 2 2 |
Bronchus, Hyperplasia, Lymphoid | 2 1 2 1 1 1 3 1 1 |
Interstitium, Infiltration Cellular | 4 3 4 4 3 2 2 2 2 3 3 3 3 3 3 1 3 4 4 2 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 3 1 2 2 1 1 |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 1 1 |
Olfactory Epithelium, Degeneration | 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + M + + A + + M +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
Inflammation | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infiltration Cellular, Lymphocyte | 2 2 2 1 2 1 1 3 |
Nephropathy | 1 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + A + + + + + + + + A + + + +|
Infiltration Cellular, Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
Page 23
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 1| 7| 7| | |
DAY ON TEST | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3| | |
| 4| 0| 3| 7| 3| 3| 3| 2| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.6MG/M3 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Gallbladder | + + + M + + + A + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + A + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + A + + | 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + A + + | 54 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 2 3.5|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + A + + | 53 |
Inflammation | 2 | 2 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + A + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + A + + | 52 |
Peyer's Patch, Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 60 |
Angiectasis | | 1 4.0|
Atrophy | | 4 2.8|
Basophilic Focus | | 1 |
Degeneration | | 1 2.0|
Eosinophilic Focus | | 1 |
Infarct | | 2 4.0|
Infiltration Cellular, Lymphocyte | 1 | 2 1.5|
Inflammation | 2 | 3 2.0|
Mixed Cell Focus | | 1 |
Necrosis | | 3 2.0|
Pigmentation, Hemosiderin | | 1 3.0|
__________________________________________________________________________|____________|
Mesentery | | 4 |
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + + M + + + A + + | 56 |
Cyst | | 1 |
Infiltration Cellular, Lymphocyte | 1 | 3 1.7|
Inflammation | | 1 4.0|
Acinus, Atrophy | | 1 4.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 60 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + A + + | 58 |
Inflammation | | 5 1.2|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 1| 7| 7| | |
DAY ON TEST | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3| | |
| 4| 0| 3| 7| 3| 3| 3| 2| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.6MG/M3 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 60 |
Cardiomyopathy | | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
Angiectasis | | 1 2.0|
Atrophy | | 1 3.0|
Hyperplasia, Focal | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
Angiectasis | | 2 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + M + + + A + + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 57 |
Angiectasis | 2 2 | 6 2.8|
Pars Distalis, Hyperplasia | | 10 3.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 60 |
Follicular Cell, Hyperplasia | 1 2 1 2 | 28 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 4 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 59 |
Atrophy | | 1 3.0|
Ectasia | | 1 1.0|
Inflammation | | 2 1.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + A + + | 58 |
Abscess | | 1 4.0|
Cyst | | 8 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 60 |
Abscess | | 1 4.0|
Cyst | | 3 |
Cyst, Multiple | X | 2 |
Inflammation | | 1 1.0|
Endometrium, Hyperplasia | 2 2 | 19 2.6|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 60 |
Erythroid Cell, Hyperplasia | 2 | 3 2.7|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 1| 7| 7| | |
DAY ON TEST | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3| | |
| 4| 0| 3| 7| 3| 3| 3| 2| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.6MG/M3 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Myeloid Cell, Atrophy | | 1 3.0|
Myeloid Cell, Hyperplasia | 3 3 | 7 2.9|
__________________________________________________________________________|____________|
Lymph Node | + | 12 |
Iliac, Hyperplasia, Lymphoid | | 1 4.0|
Pancreatic, Inflammation | | 1 3.0|
Renal, Hyperplasia, Lymphoid | | 2 4.0|
Renal, Inflammation, Granulomatous | 4 | 1 4.0|
Renal, Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + | 57 |
Hyperplasia, Lymphoid | 1 2 3 1 1 4 1 3 | 46 2.2|
Hyperplasia, Macrophage | 1 1 1 1 2 2 2 1 | 44 1.5|
Inflammation, Granulomatous | 3 | 1 3.0|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 59 |
Hyperplasia, Lymphoid | 2 3 | 7 2.4|
Hyperplasia, Plasma Cell | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + A + + | 54 |
Hyperplasia, Lymphoid | | 4 2.8|
Inflammation | | 1 4.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M + M M + + + M I + | 28 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 60 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | 3 2 | 15 2.7|
Hyperplasia, Lymphoid | 2 2 3 2 3 | 27 2.4|
Red Pulp, Atrophy | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + A + + | 57 |
Degeneration | | 5 3.0|
Hyperplasia, Lymphoid | | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + M + + | 59 |
Hyperplasia | 2 3 | 11 2.5|
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 60 |
Femur, Hyperostosis | X | 9 |
Tibia, Fracture | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 3 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 5| 7| 1| 7| 7| | |
DAY ON TEST | 3| 2| 2| 1| 3| 6| 3| 1| 3| 3| | |
| 4| 0| 3| 7| 3| 3| 3| 2| 6| 5| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
0.6MG/M3 | 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 9| 0| 1| 2| 3| 4| 5| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 60 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + I + + + + + | 55 |
Inflammation | | 1 1.0|
Epithelium, Hyperplasia | 4 | 1 4.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Bronchiectasis | | 1 3.0|
Fibrosis | | 7 1.0|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 2 1 1 1 2 1 2 2 | 46 1.7|
Alveolar Epithelium, Hyperplasia | 2 2 2 1 2 2 1 2 1 | 53 1.8|
Alveolus, Hyperplasia, Macrophage | 4 2 2 2 3 3 3 1 3 3 | 57 2.6|
Alveolus, Proteinosis | 4 3 3 2 2 2 4 3 3 | 54 2.8|
Bronchus, Hyperplasia, Lymphoid | 2 1 2 | 26 1.7|
Interstitium, Infiltration Cellular | 3 2 3 3 3 3 3 2 3 | 53 2.6|
__________________________________________________________________________|____________|
Nose | + + + + + + + A + + | 59 |
Inflammation, Acute | 1 | 11 1.8|
Olfactory Epithelium, Atrophy | 1 | 11 1.0|
Olfactory Epithelium, Degeneration | | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | + | 1 |
Inflammation | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 60 |
Hydronephrosis | | 1 3.0|
Infiltration Cellular, Lymphocyte | | 12 1.8|
Nephropathy | | 2 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + A + + | 55 |
Infiltration Cellular, Lymphocyte | | 3 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 4| 1| 1| 4| 4| 4| 4| 1| 4| 1| 4| 1| 4| 1| 1| 1| 1| 1| 4| 4| | |
DAY ON TEST | 7| 9| 9| 7| 7| 7| 7| 9| 7| 9| 7| 9| 7| 9| 9| 9| 9| 9| 7| 7| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | A |
0.6MG/M3 | 5| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| | L |
LUNG TOX | 2| 3| 4| 9| 0| 5| 0| 9| 2| 6| 7| 8| 9| 0| 2| 4| 7| 0| 6| 7| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + | 5 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + M | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + | 5 |
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + | 5 |
__________________________________________________________________________|____________|
Pancreas | + + + + + | 5 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + | 5 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + | 5 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Ovary | + + + + + | 5 |
__________________________________________________________________________|____________|
Uterus | + + + + + | 5 |
Endometrium, Hyperplasia | 2 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 4| 1| 1| 4| 4| 4| 4| 1| 4| 1| 4| 1| 4| 1| 1| 1| 1| 1| 4| 4| | |
DAY ON TEST | 7| 9| 9| 7| 7| 7| 7| 9| 7| 9| 7| 9| 7| 9| 9| 9| 9| 9| 7| 7| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| | A |
0.6MG/M3 | 5| 5| 5| 5| 6| 6| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 0| 1| 1| | L |
LUNG TOX | 2| 3| 4| 9| 0| 5| 0| 9| 2| 6| 7| 8| 9| 0| 2| 4| 7| 0| 6| 7| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + M + + | 9 |
Hyperplasia, Lymphoid | 3 2 4 2 2 1 | 6 2.3|
Hyperplasia, Macrophage | 2 1 1 1 1 1 | 6 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + M + + + | 7 |
Hyperplasia, Lymphoid | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + | 5 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M M M I | |
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
__________________________________________________________________________|____________|
Thymus | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + | 5 |
__________________________________________________________________________|____________|
Skin | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + M | 4 |
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Inflammation, Chronic Active | 2 2 3 3 1 1 | 6 2.0|
Alveolar Epithelium, Hyperplasia | 1 1 | 2 1.0|
Alveolus, Hyperplasia, Macrophage | 1 1 2 2 1 1 2 1 1 1 | 10 1.3|
Alveolus, Proteinosis | 3 1 2 4 1 4 1 1 1 | 9 2.0|
Bronchus, Hyperplasia, Lymphoid | 2 2 1 3 | 4 2.0|
Interstitium, Infiltration Cellular | 1 1 3 3 2 2 2 1 2 1 | 10 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Trachea | + + + + + | 5 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + | 5 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|
| 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + M A + + A + A + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + A + A A + + + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + M + + + + + + + + + + M M M + M M M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + A A + + + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + A A + A A + A + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + A A + A A + A + + A + A + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + A A + A + + A + A + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Atrophy | |
Basophilic Focus | |
Degeneration | 3 3 |
Eosinophilic Focus | X |
Infarct | 4 |
Infiltration Cellular, Lymphocyte | |
Inflammation | 3 |
Mixed Cell Focus | |
Necrosis | |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation | |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + A + + + + + + + A + + + + + + + + +|
Hyperplasia, Focal, Squamous | 2 |
Inflammation | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + A + + + + + + + A + + + + + + + + +|
Inflammation | 1 2 1 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | 4|
Degeneration | 2 |
Hematopoietic Cell Proliferation | |
Hyperplasia | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 30
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|
| 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + A + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + M + I + + + M + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Pars Distalis, Hyperplasia | 2 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
Follicular Cell, Hyperplasia | 3 1 1 2 1 2 1 1 3 1 2 3 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
Thoracic, Inflammation | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + + + + + + + + M M + + + + A M + + + + + + + +|
Atrophy | 3 3 3 3 2 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 4|
Cyst | X X 3 X |
Hemorrhage | 2 |
Periovarian Tissue, Cyst | X |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 X X|
Inflammation | 2 |
Endometrium, Hyperplasia | 3 3 1 3 2 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + A + + + + + + + + +|
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 3 4|
__________________________________________________________________________|
Lymph Node | + + + + +|
Iliac, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia | |
Pancreatic, Inflammation | 4|
Renal, Hyperplasia, Lymphoid | 4 4|
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 2 1 1 4 1 2 3 2 2 1 3 3 3 4 1 3 4|
Hyperplasia, Macrophage | 2 2 1 2 2 1 1 1 2 2 2 2 1 1 2 3 2 2 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 4 4|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + A + + + + + + + + + M + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 31
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|
| 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 2 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M + I M M + + M + + + + M + M + I M + M M M +|
Hyperplasia, Lymphoid | 4|
Inflammation | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 3 3 2 3 2 2|
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + M + + + M + + +|
Degeneration | 3 2 3 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Inflammation | 2 |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Pinna, Cyst Epithelial Inclusion | X |
Pinna, Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | |
Inflammation | 3|
Femur, Hyperostosis | X X |
Maxilla, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | +|
Abscess | 4|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | I I + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 2 2 1 1 1 1 |
Inflammation, Chronic Active | 1 2 2 3 2 2 2 2 2 1 3 2 2 2 2 3 1 2 1 3 1 1 2|
Alveolar Epithelium, Hyperplasia | 2 3 3 2 2 3 2 2 1 2 1 2 3 1 1 2 2 2 2 2 2 3 2 3|
Alveolus, Hyperplasia, Macrophage | 2 3 3 2 4 3 3 2 4 3 3 3 2 3 3 1 3 2 3 2 3 3 3 3 3|
Alveolus, Proteinosis | 4 4 3 3 3 4 3 4 4 4 4 3 4 3 4 3 4 3 4 3 3 3 4 2 4|
Bronchus, Hyperplasia, Lymphoid | 1 4 1 1 3 1 3 1 1|
Interstitium, Infiltration Cellular | 3 2 3 1 2 2 3 2 3 3 2 3 4 2 1 2 1 2 2 2 2 2 3 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 32
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 5| 7| 7| 6| 6| 7| 7| 6| 7| 7| 7| 7| 2| 7| 6| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 8| 3| 3| 2| 0| 3| 2| 8| 3| 0| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3|
| 5| 3| 6| 8| 5| 4| 8| 7| 5| 9| 5| 5| 3| 4| 6| 9| 6| 2| 4| 0| 5| 0| 4| 6| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|
| 1| 2| 3| 6| 7| 8| 9| 2| 3| 4| 5| 8| 9| 0| 1| 2| 5| 7| 9| 0| 2| 3| 4| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 2 2 2 1|
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 2 1 1 1 1 1 1 1 2 1 1 |
Olfactory Epithelium, Degeneration | 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + M + + + + + + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 4 |
Infiltration Cellular, Lymphocyte | |
Metaplasia, Osseous | |
Nephropathy | 1|
Pelvis, Inflammation | 3 |
Renal Tubule, Pigmentation, | |
Hemosiderin | |
__________________________________________________________________________|
Urethra | + |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + A + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 33
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|
| 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + M + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + M + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M + + + + + + + + + + M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Atrophy | 3 |
Basophilic Focus | X |
Degeneration | 2 |
Eosinophilic Focus | X X |
Infarct | 4|
Infiltration Cellular, Lymphocyte | 2 4|
Inflammation | |
Mixed Cell Focus | |
Necrosis | 4 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Oral Mucosa | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 4 |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal, Squamous | |
Inflammation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Tooth | |
Developmental Malformation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Atrophy | |
Degeneration | |
Hematopoietic Cell Proliferation | 2 |
Hyperplasia | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|
| 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Angiectasis | |
Hyperplasia | |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 4 |
Pars Distalis, Hyperplasia | 3 3 3 4 3 4 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
Follicular Cell, Hyperplasia | 2 1 1 2 3 3 1 1 2 2 1 1 2 2 2 1 1 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
Thoracic, Inflammation | 2 |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | + + M + + + + + M + + + + + + + + + + + + M + + +|
Atrophy | 2 3 3 |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X X X X X |
Hemorrhage | |
Periovarian Tissue, Cyst | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Inflammation | |
Endometrium, Hyperplasia | 3 2 3 3 3 3 3 3 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia, Lymphoid | |
Pancreatic, Hyperplasia | 3 |
Pancreatic, Inflammation | |
Renal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 2 1 1 2 1 1 3 1 2 2 3 3 2 2 4 2 4 3 4 3 2 3|
Hyperplasia, Macrophage | 2 2 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 1 1|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|
| 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 2 4|
Inflammation | 3 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | I M M I + + M I + + + + M M M M + M + M + M + M +|
Hyperplasia, Lymphoid | 4 |
Inflammation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 1 2 3 |
Hyperplasia, Lymphoid | 2 3 2 2 2 1 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + M + + + + M + + +|
Degeneration | 4 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 2 2 2 |
Inflammation | |
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Pinna, Cyst Epithelial Inclusion | |
Pinna, Hyperkeratosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | X |
Inflammation | |
Femur, Hyperostosis | X X X X X X X |
Maxilla, Hyperostosis | |
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
Abscess | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + I + + + + + M + + + I + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 1 1 1 1 1 1|
Inflammation, Chronic Active | 3 2 1 2 2 1 3 1 1 2 1 2 1 3 2 2 2 2 2 2 2 2 3 3 2|
Alveolar Epithelium, Hyperplasia | 3 2 1 2 2 2 3 2 3 2 1 2 1 3 3 2 2 2 2 2 1 1 2 2 2|
Alveolus, Hyperplasia, Macrophage | 4 3 2 3 3 2 3 3 3 3 3 3 1 4 3 4 3 3 3 2 3 2 4 4 3|
Alveolus, Proteinosis | 2 4 4 4 3 3 4 4 4 2 2 3 3 4 4 4 4 4 2 4 3 4 3 1 3|
Bronchus, Hyperplasia, Lymphoid | 1 1 1 1 2 1 1 1 1 1 1 1 1 1 3 1 1 1 1 2 |
Interstitium, Infiltration Cellular | 3 2 2 3 3 1 2 2 2 2 2 2 2 2 2 1 2 2 4 2 3 1 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 4| 7| 7| 5| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7|
DAY ON TEST | 3| 3| 9| 3| 3| 8| 3| 3| 3| 3| 3| 3| 4| 3| 3| 3| 7| 3| 3| 0| 3| 5| 3| 3| 3|
| 3| 4| 9| 5| 5| 0| 3| 3| 3| 5| 6| 3| 0| 5| 5| 6| 2| 4| 5| 7| 5| 3| 6| 4| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
1.2MG/M3 | 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|
| 8| 9| 1| 2| 3| 4| 5| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Inflammation, Acute | 1 1 2 2 2 2 2 |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 1 1 2 1 1 1 1 1 1 1 1 1|
Olfactory Epithelium, Degeneration | 1 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + + |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | |
Infiltration Cellular, Lymphocyte | |
Metaplasia, Osseous | |
Nephropathy | |
Pelvis, Inflammation | |
Renal Tubule, Pigmentation, | |
Hemosiderin | 4 |
__________________________________________________________________________|
Urethra | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 4| 7| 5| 4| | |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 7| 3| 8| 7| | |
| 3| 5| 3| 3| 2| 5| 7| 3| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2MG/M3 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 8| 0| 1| 3| 5| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + M + + | 46 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + | 52 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + | 58 |
Angiectasis | 3 | 3 3.7|
Atrophy | | 1 3.0|
Basophilic Focus | | 1 |
Degeneration | | 3 2.7|
Eosinophilic Focus | | 3 |
Infarct | | 2 4.0|
Infiltration Cellular, Lymphocyte | 2 | 3 2.7|
Inflammation | | 1 3.0|
Mixed Cell Focus | X | 1 |
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Oral Mucosa | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + | 57 |
Inflammation | | 1 4.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + | 56 |
Hyperplasia, Focal, Squamous | | 1 2.0|
Inflammation | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + | 56 |
Inflammation | | 4 1.3|
__________________________________________________________________________|____________|
Tooth | | 1 |
Developmental Malformation | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + | 57 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + | 58 |
Angiectasis | | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 4| 7| 5| 4| | |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 7| 3| 8| 7| | |
| 3| 5| 3| 3| 2| 5| 7| 3| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2MG/M3 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 8| 0| 1| 3| 5| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Atrophy | | 1 4.0|
Degeneration | | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + | 58 |
Angiectasis | 3 | 1 3.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + | 57 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + | 53 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + | 58 |
Angiectasis | | 1 4.0|
Pars Distalis, Hyperplasia | 2 3 2 | 11 2.9|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + | 58 |
Inflammation | | 1 1.0|
Follicular Cell, Hyperplasia | 3 3 1 1 2 | 37 1.8|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
Thoracic, Inflammation | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + | 51 |
Atrophy | | 8 2.8|
__________________________________________________________________________|____________|
Ovary | + + + + + + + + | 58 |
Abscess | | 1 4.0|
Cyst | X X | 11 3.0|
Hemorrhage | | 1 2.0|
Periovarian Tissue, Cyst | | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 58 |
Cyst | | 3 2.0|
Inflammation | 2 3 | 3 2.3|
Endometrium, Hyperplasia | 3 3 3 | 19 2.7|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | 1 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + | 57 |
Erythroid Cell, Hyperplasia | 2 | 1 2.0|
Myeloid Cell, Hyperplasia | 2 | 5 2.8|
__________________________________________________________________________|____________|
Lymph Node | + + | 11 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 4| 7| 5| 4| | |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 7| 3| 8| 7| | |
| 3| 5| 3| 3| 2| 5| 7| 3| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2MG/M3 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 8| 0| 1| 3| 5| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Iliac, Hyperplasia, Lymphoid | 4 4 | 2 4.0|
Pancreatic, Hyperplasia | | 1 3.0|
Pancreatic, Inflammation | | 1 4.0|
Renal, Hyperplasia, Lymphoid | | 3 3.3|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + | 58 |
Hyperplasia, Lymphoid | 4 4 1 2 4 3 3 2 | 51 2.4|
Hyperplasia, Macrophage | 1 2 2 3 2 1 3 2 | 47 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + | 58 |
Hyperplasia, Lymphoid | 4 | 4 3.5|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + | 55 |
Hyperplasia, Lymphoid | 3 | 6 2.8|
Inflammation | | 2 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + + + M + + + M | 29 |
Hyperplasia, Lymphoid | 4 1 | 4 3.3|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + | 58 |
Hematopoietic Cell Proliferation | 2 3 | 8 2.3|
Hyperplasia, Lymphoid | 2 2 2 3 4 3 | 19 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + | 53 |
Degeneration | | 7 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + | 58 |
Hyperplasia | 1 2 | 7 1.9|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Skin | + + + + + + + + | 58 |
Hemorrhage | | 1 2.0|
Pinna, Cyst Epithelial Inclusion | | 1 |
Pinna, Hyperkeratosis | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + | 57 |
Hyperostosis | | 1 |
Inflammation | | 1 3.0|
Femur, Hyperostosis | X | 10 |
Maxilla, Hyperostosis | X | 1 |
__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 7| 5| 7| 7| 7| 4| 7| 5| 4| | |
DAY ON TEST | 3| 3| 6| 3| 3| 3| 7| 3| 8| 7| | |
| 3| 5| 3| 3| 2| 5| 7| 3| 0| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2MG/M3 | 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 6| 8| 0| 1| 3| 5| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Spinal Cord | | 1 |
Abscess | | 1 4.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + I + + + + I + | 51 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + | 58 |
Fibrosis | 1 1 | 17 1.1|
Inflammation, Chronic Active | 3 3 1 3 3 3 3 2 | 56 2.0|
Alveolar Epithelium, Hyperplasia | 2 2 2 2 2 3 2 2 | 57 2.1|
Alveolus, Hyperplasia, Macrophage | 4 4 3 4 3 3 3 3 | 58 2.9|
Alveolus, Proteinosis | 4 3 4 4 3 3 4 4 | 58 3.4|
Bronchus, Hyperplasia, Lymphoid | 3 2 3 2 2 | 34 1.5|
Interstitium, Infiltration Cellular | 2 2 2 2 3 3 2 2 | 57 2.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + | 58 |
Inflammation, Acute | 2 1 | 13 1.7|
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 | 41 1.1|
Olfactory Epithelium, Degeneration | 1 1 | 12 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + | 58 |
Hydronephrosis | | 1 4.0|
Infiltration Cellular, Lymphocyte | 2 | 1 2.0|
Metaplasia, Osseous | 2 | 1 2.0|
Nephropathy | | 1 1.0|
Pelvis, Inflammation | | 1 3.0|
Renal Tubule, Pigmentation, | | |
Hemosiderin | | 1 4.0|
__________________________________________________________________________|____________|
Urethra | | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + | 57 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 4| 4| 1| 4| 1| 1| 1| 1| 0| 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1| | |
DAY ON TEST | 7| 7| 9| 7| 9| 9| 9| 9| 7| 7| 7| 9| 9| 7| 9| 9| 7| 7| 4| 9| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2MG/M3 | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 6| 6| 6| 7| 7| 7| | L |
LUNG TOX | 4| 5| 0| 1| 6| 7| 3| 4| 6| 8| 1| 5| 0| 9| 1| 7| 9| 2| 4| 6| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + | 7 |
Hyperplasia, Lymphoid | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 7 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 7 |
Cardiomyopathy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + | 7 |
Degeneration | 1 2 | 2 1.5|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + + + + + | 6 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + M + + + | 5 |
Ectasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + | 8 |
Endometrium, Hyperplasia | 2 2 2 | 3 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 4| 4| 1| 4| 1| 1| 1| 1| 0| 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1| | |
DAY ON TEST | 7| 7| 9| 7| 9| 9| 9| 9| 7| 7| 7| 9| 9| 7| 9| 9| 7| 7| 4| 9| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2MG/M3 | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 6| 6| 6| 7| 7| 7| | L |
LUNG TOX | 4| 5| 0| 1| 6| 7| 3| 4| 6| 8| 1| 5| 0| 9| 1| 7| 9| 2| 4| 6| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + I + + + + + + + | 11 |
Hyperplasia, Lymphoid | 2 3 3 2 2 3 | 6 2.5|
Hyperplasia, Macrophage | 1 1 1 1 1 1 | 6 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
Hyperplasia, Lymphoid | 2 1 3 | 3 2.0|
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 7 |
Hyperplasia, Lymphoid | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | I M + M M + M M M I M + | 3 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 7 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + M | 6 |
Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 7 |
Inflammation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 7 |
Thalamus, Degeneration, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + M + | 6 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 12 |
Inflammation, Chronic Active | 1 1 2 1 1 1 1 1 2 1 2 2 | 12 1.3|
Alveolar Epithelium, Hyperplasia | 2 1 2 1 2 2 | 6 1.7|
Alveolus, Hyperplasia, Macrophage | 1 2 1 1 1 3 3 2 3 1 3 2 | 12 1.9|
Alveolus, Proteinosis | 1 4 2 1 2 4 2 4 1 4 4 | 11 2.6|
Bronchus, Hyperplasia, Lymphoid | 2 1 1 1 | 4 1.3|
Interstitium, Infiltration Cellular | 1 1 1 3 2 2 2 2 1 3 | 10 1.8|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 43
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 4| 4| 1| 4| 1| 1| 1| 1| 0| 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1| | |
DAY ON TEST | 7| 7| 9| 7| 9| 9| 9| 9| 7| 7| 7| 9| 9| 7| 9| 9| 7| 7| 4| 9| | |
| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | A |
1.2MG/M3 | 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 3| 4| 4| 6| 6| 6| 7| 7| 7| | L |
LUNG TOX | 4| 5| 0| 1| 6| 7| 3| 4| 6| 8| 1| 5| 0| 9| 1| 7| 9| 2| 4| 6| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 12 |
Inflammation, Acute | 2 | 1 2.0|
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 12 |
Nephropathy | 2 | 1 2.0|
Glomerulus, Inflammation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 44
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 5| 5| 5| 5| 4| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7|
DAY ON TEST | 4| 8| 8| 4| 6| 7| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3|
| 0| 4| 6| 4| 1| 6| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + + M + + M + + + + + + M + M + A + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A A + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | M + + + + + + + + + + + + + + + + + A A + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | |
Degeneration | 3 |
Eosinophilic Focus | X |
Infarct | |
Infiltration Cellular, Lymphocyte | |
Inflammation | 2 1 |
Mixed Cell Focus | |
Necrosis | 2 1 4 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
Hyperplasia, Focal | 2 |
__________________________________________________________________________|
Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + M + M + + + + M + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + I + + + +|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 5| 5| 5| 5| 4| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7|
DAY ON TEST | 4| 8| 8| 4| 6| 7| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3|
| 0| 4| 6| 4| 1| 6| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | 1 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 2 2 1 1 2 1 2 3 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + + + + |
Concretion | 2 |
Inflammation | 2 2 1 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 2|
Ectasia | 4 3 3 3 3 3 3 2 2 4 1 2 |
Hyperplasia | 1 |
Inflammation, Chronic | 4 4 4 2 2 4 3 4|
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 3 4 3 3 4 2 2 2 4 2 2|
__________________________________________________________________________|
Lymph Node | + + + + + + +|
Iliac, Hyperplasia, Lymphoid | 2 3 4 |
Iliac, Hyperplasia, Plasma Cell | |
Iliac, Inflammation | 4 |
Iliac, Pigmentation | 1 |
Inguinal, Hyperplasia, Lymphoid | 3 4 2 |
Inguinal, Hyperplasia, Plasma Cell | 4|
Inguinal, Pigmentation | |
Lumbar, Hyperplasia, Plasma Cell | |
Lumbar, Pigmentation | |
Renal, Hyperplasia, Lymphoid | 3 |
Renal, Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Bronchial | M + M + + M + + + + + + + M + + + M + + M + + M|
Hyperplasia, Lymphoid | 2 4 |
Hyperplasia, Macrophage | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 5| 5| 5| 5| 4| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7|
DAY ON TEST | 4| 8| 8| 4| 6| 7| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3|
| 0| 4| 6| 4| 1| 6| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + M + + + +|
Hyperplasia, Lymphoid | 3|
Hyperplasia, Macrophage | |
Inflammation | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | + M M M M M + + M M + M + M M + M M M M + M M M|
Hyperplasia, Lymphoid | 3 2 |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 4 |
Hyperplasia, Lymphoid | 2 2 2 3 4 3 2 |
__________________________________________________________________________|
Thymus | + M + + + + + M + + + + + + + + + + + + + + M +|
Degeneration | 3 3 3 4 2 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Inflammation | |
Pinna, Hyperkeratosis | 2 |
Prepuce, Inflammation | 4 3 4 4 4 4 4 3 |
Tail, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + +|
Medulla, Demyelination | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
Alveolar Epithelium, Hyperplasia | 3 |
Alveolus, Hyperplasia, Macrophage | 3 4 3 |
Bronchus, Hyperplasia, Lymphoid | 1 2 1 2 2 1 1 1 1|
Interstitium, Infiltration Cellular | 1 1 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 47
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 5| 5| 5| 5| 4| 6| 7| 6| 7| 7| 5| 7| 4| 7| 7| 5| 4| 7| 7| 4| 5| 7| 6| 7|
DAY ON TEST | 4| 8| 8| 4| 6| 7| 7| 4| 8| 3| 4| 5| 4| 8| 4| 4| 8| 9| 4| 1| 0| 3| 4| 8| 3|
| 0| 4| 6| 4| 1| 6| 9| 0| 1| 7| 0| 7| 0| 0| 1| 0| 4| 9| 1| 9| 6| 6| 0| 1| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 3|
| 1| 2| 3| 4| 5| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7| 9| 0| 1| 2| 4| 5| 6| 7| 9| 1|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 3 3 |
Infiltration Cellular, Lymphocyte | 2 2 |
Inflammation | 4 2 4 3 |
Nephropathy | 1 1 1 1 |
Pelvis, Inflammation | 2 |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Ureter | + |
Inflammation | 1 |
__________________________________________________________________________|
Urethra | + + |
Concretion | 3 3 |
Inflammation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | X |
Crystals | 4 |
Inflammation | 4 1 1 3 4 |
_____________________________________________________________________________________________________________________|
Page 48
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7|
DAY ON TEST | 3| 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4|
| 7| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + I + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + M + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + M M + + + + M + + + + + + M + M M M + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + A + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Basophilic Focus | X |
Degeneration | |
Eosinophilic Focus | X |
Infarct | 4 4 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | |
Mixed Cell Focus | X |
Necrosis | 2 2 3 |
__________________________________________________________________________|
Mesentery | + |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy | |
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Tooth | + + +|
Developmental Malformation | |
Inflammation | 3 3 2|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Hyperplasia, Focal | |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + I + + + + + + + + + + + + + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 49
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7|
DAY ON TEST | 3| 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4|
| 7| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 2 2 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + |
Concretion | 3 2 |
Inflammation | 3 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Ectasia | 3 3 1 1 3 3 3 3 3 1 2|
Hyperplasia | |
Inflammation, Chronic | 4 4 3 1 4 2 1 2 4 3 2 3 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | 2 |
Myeloid Cell, Hyperplasia | 3 3 4 4 3 2 2 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + + + + |
Iliac, Hyperplasia, Lymphoid | |
Iliac, Hyperplasia, Plasma Cell | 4 3 2 2 4 4 |
Iliac, Inflammation | |
Iliac, Pigmentation | 1 |
Inguinal, Hyperplasia, Lymphoid | 2 4 |
Inguinal, Hyperplasia, Plasma Cell | 4 |
Inguinal, Pigmentation | 1 |
Lumbar, Hyperplasia, Plasma Cell | 3 |
Lumbar, Pigmentation | 2 |
Renal, Hyperplasia, Lymphoid | |
Renal, Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + I M + M + + + M M + + M I I + +|
Hyperplasia, Lymphoid | 1 2 |
Hyperplasia, Macrophage | 3 |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + M + M + + + + + + + + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 50
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7|
DAY ON TEST | 3| 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4|
| 7| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 4 |
Hyperplasia, Plasma Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + M + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Macrophage | |
Inflammation | 3 |
__________________________________________________________________________|
Lymph Node, Mediastinal | M I M M + M M + M M M M M M I + M M M M M M M M M|
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 2 3 |
Hyperplasia, Lymphoid | 2 2 3 3 4 2 |
__________________________________________________________________________|
Thymus | M + + + I M + M M M M + M + + M + + + + + + + + +|
Degeneration | 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Inflammation | 4 4 |
Pinna, Hyperkeratosis | |
Prepuce, Inflammation | 4 4 2 4 4 3 4 |
Tail, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Medulla, Demyelination | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + I + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 1 |
Alveolar Epithelium, Hyperplasia | 4 1|
Alveolus, Hyperplasia, Macrophage | 2 2 2 |
Bronchus, Hyperplasia, Lymphoid | 1 1 1 1 1 1 1 1 1|
Interstitium, Infiltration Cellular | 1 1 1 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | |
Olfactory Epithelium, Degeneration | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 51
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 7| 7| 7| 6| 5| 5| 7| 6| 6| 2| 5| 5| 6| 7| 7| 7| 7| 7| 6| 5| 5| 7| 6| 7| 7|
DAY ON TEST | 3| 4| 4| 0| 8| 0| 3| 4| 6| 1| 2| 5| 2| 4| 1| 4| 4| 4| 9| 5| 9| 3| 8| 3| 4|
| 7| 1| 0| 5| 9| 8| 7| 1| 2| 2| 6| 2| 0| 0| 3| 0| 1| 1| 4| 2| 1| 7| 1| 7| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
0.0MG/M3 | 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6|
| 2| 3| 4| 5| 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 2| 3| 6| 7| 9| 0| 1| 2| 3| 4| 7|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Harderian Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 3 2 3 |
Infiltration Cellular, Lymphocyte | 1 2 1 2 |
Inflammation | |
Nephropathy | 1 1 1 1 1 |
Pelvis, Inflammation | 2 2 2 2 |
Renal Tubule, Degeneration | |
__________________________________________________________________________|
Ureter | |
Inflammation | |
__________________________________________________________________________|
Urethra | + + + |
Concretion | 3 3 3 |
Inflammation | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | |
Crystals | |
Inflammation | 4 4 4 1 4 |
_____________________________________________________________________________________________________________________|
Page 52
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 4| 7| 5| 5| 7| 7| 6| | |
DAY ON TEST | 1| 4| 3| 6| 3| 8| 8| 4| 4| 3| | |
| 3| 0| 7| 3| 7| 8| 5| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + M M + | 44 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 56 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 56 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 59 |
Angiectasis | 3 | 1 3.0|
Basophilic Focus | X | 2 |
Degeneration | | 1 3.0|
Eosinophilic Focus | | 2 |
Infarct | | 2 4.0|
Infiltration Cellular, Lymphocyte | | 1 2.0|
Inflammation | | 2 1.5|
Mixed Cell Focus | | 1 |
Necrosis | 2 | 7 2.3|
__________________________________________________________________________|____________|
Mesentery | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 59 |
Acinus, Atrophy | 2 | 1 2.0|
Acinus, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 59 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Tooth | | 4 |
Developmental Malformation | | 1 |
Inflammation | | 3 2.7|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 59 |
Cardiomyopathy | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 59 |
Cyst | | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 4| 7| 5| 5| 7| 7| 6| | |
DAY ON TEST | 1| 4| 3| 6| 3| 8| 8| 4| 4| 3| | |
| 3| 0| 7| 3| 7| 8| 5| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Hyperplasia, Focal | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M + + + + + | 56 |
Pars Distalis, Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 59 |
Follicular Cell, Hyperplasia | 1 1 2 2 2 1 | 27 1.5|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Penis | + | 12 |
Concretion | 4 | 4 2.8|
Inflammation | | 5 2.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 59 |
Atrophy | | 3 2.3|
Ectasia | 2 2 2 4 | 27 2.6|
Hyperplasia | 3 | 2 2.0|
Inflammation, Chronic | 3 2 4 | 24 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 59 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 59 |
Hyperplasia | | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 59 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 59 |
Erythroid Cell, Hyperplasia | 2 | 2 2.0|
Myeloid Cell, Hyperplasia | 4 3 2 2 | 23 2.9|
__________________________________________________________________________|____________|
Lymph Node | + + | 18 |
Iliac, Hyperplasia, Lymphoid | | 3 3.0|
Iliac, Hyperplasia, Plasma Cell | 4 | 7 3.3|
Iliac, Inflammation | | 1 4.0|
Iliac, Pigmentation | | 2 1.0|
Inguinal, Hyperplasia, Lymphoid | 2 | 6 2.8|
Inguinal, Hyperplasia, Plasma Cell | | 2 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 4| 7| 5| 5| 7| 7| 6| | |
DAY ON TEST | 1| 4| 3| 6| 3| 8| 8| 4| 4| 3| | |
| 3| 0| 7| 3| 7| 8| 5| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inguinal, Pigmentation | | 1 1.0|
Lumbar, Hyperplasia, Plasma Cell | | 1 3.0|
Lumbar, Pigmentation | | 1 2.0|
Renal, Hyperplasia, Lymphoid | | 1 3.0|
Renal, Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + M + + + M I + M + | 39 |
Hyperplasia, Lymphoid | | 4 2.3|
Hyperplasia, Macrophage | | 1 3.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + + M + M + M | 51 |
Hyperplasia, Lymphoid | 2 | 3 3.0|
Hyperplasia, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 2 3.0|
Hyperplasia, Macrophage | 3 | 1 3.0|
Inflammation | 2 | 3 2.7|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M M M + + M | 12 |
Hyperplasia, Lymphoid | | 2 2.5|
Hyperplasia, Macrophage | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 59 |
Hematopoietic Cell Proliferation | 3 2 | 8 2.8|
Hyperplasia, Lymphoid | 2 2 1 | 16 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M | 46 |
Degeneration | 4 3 | 11 3.1|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 59 |
Alopecia | | 1 2.0|
Inflammation | | 2 4.0|
Pinna, Hyperkeratosis | | 1 2.0|
Prepuce, Inflammation | 4 | 16 3.7|
Tail, Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 59 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 3| 7| 7| 4| 7| 5| 5| 7| 7| 6| | |
DAY ON TEST | 1| 4| 3| 6| 3| 8| 8| 4| 4| 3| | |
| 3| 0| 7| 3| 7| 8| 5| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 6| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 9| 0| 1| 3| 4| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
Medulla, Demyelination | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + M + + | 57 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 59 |
Inflammation, Chronic Active | | 1 1.0|
Alveolar Epithelium, Hyperplasia | | 3 2.7|
Alveolus, Hyperplasia, Macrophage | | 6 2.7|
Bronchus, Hyperplasia, Lymphoid | 1 2 1 | 21 1.2|
Interstitium, Infiltration Cellular | 1 1 | 10 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 59 |
Olfactory Epithelium, Atrophy | 1 | 1 1.0|
Olfactory Epithelium, Degeneration | 1 | 3 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 59 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 59 |
Hydronephrosis | 2 2 | 8 2.5|
Infiltration Cellular, Lymphocyte | 2 | 7 1.7|
Inflammation | 4 | 5 3.4|
Nephropathy | | 9 1.0|
Pelvis, Inflammation | | 5 2.0|
Renal Tubule, Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ureter | + | 2 |
Inflammation | 4 | 2 2.5|
__________________________________________________________________________|____________|
Urethra | + | 6 |
Concretion | | 5 3.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 59 |
Calculus Gross Observation | | 1 |
Calculus Micro Observation Only | | 1 |
Crystals | | 1 4.0|
Inflammation | 4 | 11 3.1|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 1| 4| 4| 4| 0| 1| 1| 4| 1| 1| 1| 1| 4| 4| 1| 1| 4| | |
DAY ON TEST | 7| 7| 7| 9| 7| 7| 7| 6| 9| 9| 7| 9| 9| 9| 9| 7| 3| 9| 9| 7| | |
| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 0| 1| 1| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| | L |
LUNG TOX | 6| 3| 8| 3| 8| 0| 1| 2| 3| 4| 5| 1| 4| 5| 8| 5| 6| 8| 2| 5| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A A + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + A + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A A + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A A + | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A A + | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 7 |
Angiectasis | 3 | 1 3.0|
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | M + M + + + + | 5 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + | 7 |
Hypertrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M + M + + + | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 7 |
Ectasia | 1 2 2 2 2 | 5 1.8|
Inflammation, Chronic | 3 | 1 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Testes | + + + + + + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 1| 4| 4| 4| 0| 1| 1| 4| 1| 1| 1| 1| 4| 4| 1| 1| 4| | |
DAY ON TEST | 7| 7| 7| 9| 7| 7| 7| 6| 9| 9| 7| 9| 9| 9| 9| 7| 3| 9| 9| 7| | |
| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 0| 1| 1| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| | L |
LUNG TOX | 6| 3| 8| 3| 8| 0| 1| 2| 3| 4| 5| 1| 4| 5| 8| 5| 6| 8| 2| 5| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Lumbar, Hyperplasia, Lymphoid | 3 | 1 3.0|
Lumbar, Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | I + + + M + + M M + + + | 8 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M M M + M + + | 3 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 7 |
Hemorrhage, Chronic | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M M M + I + I M M + | 3 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 7 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 7 |
Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 7 |
Fibrosis | 3 | 1 3.0|
Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 7 |
Medulla, Degeneration, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 12 |
Bronchus, Hyperplasia, Lymphoid | 1 1 1 | 3 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 12 |
Olfactory Epithelium, Respiratory | | |
Epithelium, Degeneration | 1 | 1 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + I + + | 6 |
Inflammation, Focal | 1 1 1 | 3 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 58
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 4| 4| 4| 1| 4| 4| 4| 0| 1| 1| 4| 1| 1| 1| 1| 4| 4| 1| 1| 4| | |
DAY ON TEST | 7| 7| 7| 9| 7| 7| 7| 6| 9| 9| 7| 9| 9| 9| 9| 7| 3| 9| 9| 7| | |
| 6| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| 6| 6| 6| 6| 6| 4| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0.0MG/M3 | 0| 1| 1| 2| 2| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 6| 6| 6| 7| 7| | L |
LUNG TOX | 6| 3| 8| 3| 8| 0| 1| 2| 3| 4| 5| 1| 4| 5| 8| 5| 6| 8| 2| 5| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 12 |
__________________________________________________________________________|____________|
Urethra | + + | 2 |
Calculus Micro Observation Only | X X | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 7 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 59
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 4| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5|
DAY ON TEST | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 7| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7|
| 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 6| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6MG/M3 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M + M + + + + + + + + + + A + + A + + + + + + + +|
Epithelium, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + M + + A + M A + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + M + M + + + + + + + + A M M A + + + + + M + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + A + + + + + + + +|
Hyperplasia, Focal, Lymphoid | 4 |
Lymphoid Tissue, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Duodenum | A + + + + + + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A + + + + + + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A + + + + + + + + + + + + A + + A + + + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | 3 |
Basophilic Focus | |
Eosinophilic Focus | |
Hepatodiaphragmatic Nodule | |
Infarct | 4 |
Necrosis | 1 4 |
Pigmentation, Hemosiderin | |
Regeneration | |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | |
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 1 |
__________________________________________________________________________|
Tooth | |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | 2 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 2 |
Hyperplasia, Focal | |
Hyperplasia | |
Hypertrophy, Focal | |
Necrosis | 4 |
_____________________________________________________________________________________________________________________|
Page 60
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 4| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5|
DAY ON TEST | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 7| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7|
| 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 6| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6MG/M3 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 |
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + M + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 1 2 1 1 1 1 2|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + +|
Concretion | |
Inflammation | 4 4 4 4|
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 3 3 2 2 3 2 1 3 2 2 3 3 2|
Inflammation, Chronic | 3 1 3 2 2 4 4 2 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | 2 2 2 |
Myeloid Cell, Hyperplasia | 4 3 3 3 3 2|
__________________________________________________________________________|
Lymph Node | + + + + |
Iliac, Hyperplasia, Plasma Cell | |
Iliac, Inflammation | |
Iliac, Pigmentation | |
Inguinal, Hyperplasia, Lymphoid | 2 |
Inguinal, Hyperplasia, Plasma Cell | 3 3 |
Inguinal, Inflammation | |
Lumbar, Pigmentation | |
Pancreatic, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + I M + + + M + + + I|
Hyperplasia, Lymphoid | 4 2 2 3 1 3 2 1 1 4 4 2 1 2 1 3 |
Hyperplasia, Macrophage | 1 2 1 1 2 2 2 2 1 2 2 2 2 1 2 2 2 2 1 |
__________________________________________________________________________|
Lymph Node, Mandibular | M + M + M + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 61
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 4| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5|
DAY ON TEST | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 7| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7|
| 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 6| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6MG/M3 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 2 |
Inflammation | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M + + + M I I I I M M M M I + M + M M M I M I M|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Macrophage | |
Hyperplasia, Plasma Cell | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Hematopoietic Cell Proliferation | 3 2 3 2 2 3 |
Hyperplasia, Lymphoid | 2 2 2 3 2 |
__________________________________________________________________________|
Thymus | + + + + + + I + + + + + + + + M + + + + + M + + +|
Atrophy | 3 |
Degeneration | 3 3 3 2 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + I + + + + + + + + + + + + + + +|
Parakeratosis | |
Prepuce, Inflammation | 4 4 4 4 3 |
Tail, Hyperkeratosis | 3 |
Tail, Inflammation | |
Tail, Necrosis | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | |
Hyperostosis | X |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, White Matter, | |
Degeneration, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 1 1 |
Infiltration Cellular | |
Inflammation, Chronic Active | 1 3 2 1 1 1 1 1 1 2 2 2 3 2 3 2 2 2 1 2 2 2|
Alveolar Epithelium, Hyperplasia | 1 2 1 2 2 2 2 1 2 2 2 2 2 2 1 2 2 3 2 2 2 2 1|
Alveolus, Hyperplasia, Macrophage | 2 3 1 1 3 2 2 3 2 2 1 2 2 2 3 2 2 2 2 2 3 2 3 2|
Alveolus, Proteinosis | 3 3 3 3 4 2 4 3 4 3 3 2 2 3 3 3 4 3 4 3 3 4 3 4|
Bronchus, Hyperplasia, Lymphoid | 2 1 1 1 1 1 1 1 1 1 |
Interstitium, Infiltration Cellular | 1 3 1 1 2 1 2 2 2 2 1 2 2 1 2 2 2 2 2 2 2 2 2|
_____________________________________________________________________________________________________________________|
Page 62
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 6| 5| 7| 5| 7| 7| 7| 7| 4| 5| 6| 5| 7| 5| 0| 7| 5| 7| 5| 7| 7| 7| 5|
DAY ON TEST | 1| 4| 7| 8| 4| 8| 3| 4| 3| 4| 7| 4| 2| 3| 4| 4| 2| 4| 2| 1| 5| 3| 0| 3| 7|
| 8| 1| 4| 8| 1| 0| 7| 0| 7| 0| 6| 9| 0| 3| 0| 9| 0| 0| 1| 6| 9| 7| 4| 7| 0|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
0.6MG/M3 | 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9|
| 2| 3| 4| 6| 8| 9| 0| 1| 3| 6| 7| 8| 0| 1| 2| 3| 4| 5| 6| 8| 9| 0| 1| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 2 1 1 1 1 1 1 1 2 1|
Olfactory Epithelium, Degeneration | 1 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 1 3|
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | |
Nephropathy | 1 1 1 1 1 |
Cortex, Atrophy | |
Pelvis, Inflammation | |
__________________________________________________________________________|
Urethra | + + +|
Concretion | 3 3 3|
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | |
Calculus Micro Observation Only | |
Hyperplasia | 2 |
Inflammation | |
_____________________________________________________________________________________________________________________|
Page 63
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 2| 4| 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 4| 7| 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8|
| 4| 6| 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 6| 7| 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | M A + + + + + + + + + M + + + A + + + + A + + +|
Epithelium, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Large, Colon | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | A A + + + + M + M M + M M + + + M M + M M + + +|
__________________________________________________________________________|
Intestine Large, Cecum | A A + + + + + + + + + + + + + + + + + + A + + +|
Hyperplasia, Focal, Lymphoid | |
Lymphoid Tissue, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | A A + + + + + + + + + A + + + A + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | A A + + + + + + + + + A + + + A + + + + A + + +|
__________________________________________________________________________|
Intestine Small, Ileum | A A + + + + + + + + + A + + + A + + + + A + + +|
__________________________________________________________________________|
Liver | A + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 3 4|
Atrophy | |
Basophilic Focus | X|
Eosinophilic Focus | X |
Hepatodiaphragmatic Nodule | X X |
Infarct | 4 |
Necrosis | 4 4 3 4 |
Pigmentation, Hemosiderin | 3 |
Regeneration | 3 |
Bile Duct, Hyperplasia | |
__________________________________________________________________________|
Pancreas | A + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Stomach, Glandular | A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2|
__________________________________________________________________________|
Tooth | + |
Inflammation | 4 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | A + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | A + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration | |
Hyperplasia, Focal | 1 |
Hyperplasia | 2 |
Hypertrophy, Focal | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 64
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 2| 4| 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 4| 7| 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8|
| 4| 6| 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 6| 7| 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Medulla | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | A + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
__________________________________________________________________________|
Parathyroid Gland | A + + + + + + + + + + + + + + + + + M + + M + +|
__________________________________________________________________________|
Pituitary Gland | M + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Thyroid Gland | A + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 2 2 1 2 1 1 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + |
Concretion | 3 3 |
Inflammation | 4 |
__________________________________________________________________________|
Preputial Gland | A + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 3 2 2 2 3 2 2 3 3 2 2 3 2 2 2 |
Inflammation, Chronic | 2 4 4 |
__________________________________________________________________________|
Prostate | A + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Seminal Vesicle | A + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | A + + + + + + + + + + + + + + + + + + + + + + +|
Germinal Epithelium, Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | A + + + + + + + + + + + + + + + + + + + + + + +|
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 3 2 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + |
Iliac, Hyperplasia, Plasma Cell | 4 |
Iliac, Inflammation | |
Iliac, Pigmentation | 3 |
Inguinal, Hyperplasia, Lymphoid | 3 3 3 |
Inguinal, Hyperplasia, Plasma Cell | 3 |
Inguinal, Inflammation | |
Lumbar, Pigmentation | 2 |
Pancreatic, Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Bronchial | A + + + + + + + + I + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 1 2 4 2 2 1 1 3 1 2 4 3 1 3 3 3 1|
Hyperplasia, Macrophage | 2 1 2 2 2 2 2 2 2 1 2 1 2 2 1 2 3 2 2 2|
__________________________________________________________________________|
Lymph Node, Mandibular | A + + + + + + + + + + + + + + + + + I M + M + +|
__________________________________________________________________________|
Lymph Node, Mesenteric | A + + + + + + + + + + M + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 65
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 2| 4| 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 4| 7| 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8|
| 4| 6| 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 6| 7| 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Hyperplasia, Lymphoid | 3 3 3 |
Inflammation | 2 |
__________________________________________________________________________|
Lymph Node, Mediastinal | A M + I I + I M M + + M M + I + + + + + M M I M|
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | |
Hyperplasia, Plasma Cell | 2 |
__________________________________________________________________________|
Spleen | A + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 4 2 2 |
Hyperplasia, Lymphoid | 2 2 2 |
__________________________________________________________________________|
Thymus | A + + I + + I + + + + + + + + M + + + + + + + M|
Atrophy | |
Degeneration | 4 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | A M M M M + M M M M M M M + M M M M M M M M M M|
__________________________________________________________________________|
Skin | A + + + + + + + + + + + + + I + + + + + + + + +|
Parakeratosis | 1 |
Prepuce, Inflammation | 4 4 4 |
Tail, Hyperkeratosis | |
Tail, Inflammation | |
Tail, Necrosis | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | A + + + + + + + + + + + + + + + + + + + + + + +|
Developmental Malformation | X |
Hyperostosis | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | A + + + + + + + + + + + + + + + + + + + + + + +|
Cerebellum, White Matter, | |
Degeneration, Focal | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | A + + + + + + + + + + + + + + + + + + I + M + +|
__________________________________________________________________________|
Lung | A + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | |
Infiltration Cellular | 3 |
Inflammation, Chronic Active | 1 1 3 1 2 1 1 2 1 1 1 1 2 1 1 3 1 3 3 3 1 1|
Alveolar Epithelium, Hyperplasia | 1 1 2 2 3 1 2 2 1 1 2 2 2 1 2 2 2 2 1 2 2 1|
Alveolus, Hyperplasia, Macrophage | 1 2 3 3 3 3 2 1 2 2 1 2 3 3 2 2 2 3 3 3 3 3 2|
Alveolus, Proteinosis | 3 4 2 3 3 1 4 3 3 3 3 4 3 2 3 2 4 2 2 1 2 3 3|
Bronchus, Hyperplasia, Lymphoid | 1 1 2 1 1 2 1 1 1 1 1 1 1 1|
Interstitium, Infiltration Cellular | 1 1 2 2 1 2 1 1 1 1 1 2 3 2 1 2 2 3 1 2 1 2|
_____________________________________________________________________________________________________________________|
Page 66
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 2| 4| 4| 5| 7| 7| 7| 5| 6| 4| 4| 6| 4| 5| 6| 7| 5| 7| 5| 7| 7| 6| 7| 7| 5|
DAY ON TEST | 4| 7| 1| 1| 4| 3| 3| 6| 3| 6| 8| 7| 6| 2| 6| 4| 9| 4| 9| 4| 4| 8| 4| 4| 8|
| 4| 6| 5| 3| 0| 7| 7| 3| 6| 9| 4| 1| 9| 5| 1| 1| 2| 0| 0| 0| 0| 6| 0| 0| 1|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
0.6MG/M3 | 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2|
| 6| 7| 9| 0| 1| 4| 5| 6| 7| 9| 0| 1| 2| 4| 6| 7| 8| 9| 0| 1| 2| 4| 5| 6| 7|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
__________________________________________________________________________|
Nose | A + + + + + + + + + + + + + + + + + + + + + + +|
Olfactory Epithelium, Atrophy | 1 1 1 1 1 2 1 1 1 1 1 1 1 1 |
Olfactory Epithelium, Degeneration | 1 1 1 |
__________________________________________________________________________|
Trachea | A + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Ear | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | A + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 2 2 |
Infiltration Cellular, Lymphocyte | 3 1 |
Inflammation | 3 |
Nephropathy | 1 1 2 2 |
Cortex, Atrophy | 2 4 |
Pelvis, Inflammation | 2 |
__________________________________________________________________________|
Urethra | + + |
Concretion | 3 |
__________________________________________________________________________|
Urinary Bladder | A + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Calculus Micro Observation Only | X |
Hyperplasia | |
Inflammation | 3 4 |
_____________________________________________________________________________________________________________________|
Page 67
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 3| 1| 7| | |
DAY ON TEST | 9| 3| 4| 4| 3| 4| 4| 5| 6| 3| | |
| 2| 1| 1| 1| 7| 0| 1| 5| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.6MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 8| 9| 1| 2| 3| 4| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + | 50 |
Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 54 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + M + + + + M + | 39 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 54 |
Hyperplasia, Focal, Lymphoid | | 1 4.0|
Lymphoid Tissue, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 58 |
Angiectasis | | 3 3.0|
Atrophy | | 1 3.0|
Basophilic Focus | | 1 |
Eosinophilic Focus | X | 2 |
Hepatodiaphragmatic Nodule | | 2 |
Infarct | | 2 4.0|
Necrosis | 1 2 1 | 9 2.7|
Pigmentation, Hemosiderin | | 1 3.0|
Regeneration | | 1 3.0|
Bile Duct, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 58 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 58 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 58 |
Inflammation | | 2 1.5|
__________________________________________________________________________|____________|
Tooth | | 1 |
Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
Cardiomyopathy | | 2 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 58 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 3| 1| 7| | |
DAY ON TEST | 9| 3| 4| 4| 3| 4| 4| 5| 6| 3| | |
| 2| 1| 1| 1| 7| 0| 1| 5| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.6MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 8| 9| 1| 2| 3| 4| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
Degeneration | | 1 2.0|
Hyperplasia, Focal | 4 | 2 2.5|
Hyperplasia | | 1 2.0|
Hypertrophy, Focal | | 1 1.0|
Necrosis | | 1 4.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 58 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + | 57 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 58 |
Follicular Cell, Hyperplasia | 3 2 1 1 2 | 25 1.4|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Penis | + | 9 |
Concretion | | 2 3.0|
Inflammation | 4 | 6 4.0|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Atrophy | 2 | 1 2.0|
Ectasia | 4 3 3 | 31 2.5|
Inflammation, Chronic | 4 4 4 | 15 3.1|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 58 |
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 58 |
Germinal Epithelium, Atrophy | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 58 |
Erythroid Cell, Hyperplasia | | 3 2.0|
Myeloid Cell, Hyperplasia | 3 | 11 2.9|
__________________________________________________________________________|____________|
Lymph Node | + + | 11 |
Iliac, Hyperplasia, Plasma Cell | | 1 4.0|
Iliac, Inflammation | 3 | 1 3.0|
Iliac, Pigmentation | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 3| 1| 7| | |
DAY ON TEST | 9| 3| 4| 4| 3| 4| 4| 5| 6| 3| | |
| 2| 1| 1| 1| 7| 0| 1| 5| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.6MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 8| 9| 1| 2| 3| 4| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Inguinal, Hyperplasia, Lymphoid | 1 | 5 2.4|
Inguinal, Hyperplasia, Plasma Cell | | 3 3.0|
Inguinal, Inflammation | 2 | 1 2.0|
Lumbar, Pigmentation | | 1 2.0|
Pancreatic, Hyperplasia, Lymphoid | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + | 53 |
Hyperplasia, Lymphoid | 1 1 3 1 3 1 2 | 40 2.1|
Hyperplasia, Macrophage | 2 2 2 1 1 1 1 1 | 47 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 51 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 56 |
Hyperplasia, Lymphoid | | 5 2.8|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M M + + I M M M M | 18 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Macrophage | 1 | 1 1.0|
Hyperplasia, Plasma Cell | | 1 2.0|
__________________________________________________________________________|____________|
Spleen | M + + + + + + + + + | 57 |
Atrophy | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 11 2.5|
Hyperplasia, Lymphoid | | 8 2.1|
__________________________________________________________________________|____________|
Thymus | + + + M + + + + + + | 50 |
Atrophy | | 1 3.0|
Degeneration | 3 4 2 3 | 12 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 56 |
Parakeratosis | | 1 1.0|
Prepuce, Inflammation | 4 | 9 3.9|
Tail, Hyperkeratosis | | 1 3.0|
Tail, Inflammation | 2 | 1 2.0|
Tail, Necrosis | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 58 |
Developmental Malformation | | 1 |
Hyperostosis | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 6| 7| 7| 7| 7| 7| 7| 3| 1| 7| | |
DAY ON TEST | 9| 3| 4| 4| 3| 4| 4| 5| 6| 3| | |
| 2| 1| 1| 1| 7| 0| 1| 5| 3| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.6MG/M3 | 2| 2| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 8| 9| 1| 2| 3| 4| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 58 |
Cerebellum, White Matter, | | |
Degeneration, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + | 55 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 58 |
Fibrosis | 1 | 3 1.0|
Infiltration Cellular | | 1 3.0|
Inflammation, Chronic Active | 1 2 3 1 3 1 1 1 | 52 1.7|
Alveolar Epithelium, Hyperplasia | 1 2 3 2 1 2 1 2 | 53 1.8|
Alveolus, Hyperplasia, Macrophage | 3 2 3 3 2 2 3 1 1 2 | 57 2.2|
Alveolus, Proteinosis | 4 2 4 3 2 2 3 3 1 3 | 57 2.9|
Bronchus, Hyperplasia, Lymphoid | 1 1 1 1 1 | 29 1.1|
Interstitium, Infiltration Cellular | 1 1 2 3 2 3 2 1 2 | 54 1.7|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 58 |
Olfactory Epithelium, Atrophy | 1 1 | 26 1.1|
Olfactory Epithelium, Degeneration | 1 | 8 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 58 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ear | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 58 |
Hydronephrosis | | 5 2.0|
Infiltration Cellular, Lymphocyte | | 3 2.0|
Inflammation | | 1 3.0|
Nephropathy | 2 | 10 1.3|
Cortex, Atrophy | | 2 3.0|
Pelvis, Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + + | 7 |
Concretion | 3 3 | 6 3.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 58 |
Calculus Gross Observation | X | 2 |
Calculus Micro Observation Only | | 1 |
Hyperplasia | | 1 2.0|
Inflammation | | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1| 4| 1| 4| 1| 1| 0| 4| 1| 1| | |
DAY ON TEST | 7| 7| 9| 9| 7| 9| 9| 7| 7| 7| 9| 7| 9| 7| 9| 9| 3| 7| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.6MG/M3 | 6| 6| 6| 7| 7| 7| 7| 8| 9| 9| 9| 0| 0| 0| 1| 1| 2| 3| 3| 3| | L |
LUNG TOX | 1| 5| 7| 2| 4| 5| 9| 7| 2| 3| 8| 2| 3| 8| 3| 5| 3| 0| 5| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + | 6 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + A | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + M + + + A | 4 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + A | 5 |
Hyperplasia, Focal, Lymphoid | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + A | 5 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + A | 5 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + A | 5 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 6 |
Degeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + | 6 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + | 6 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + | 6 |
Hyperplasia, Focal | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + | 6 |
Hyperplasia, Focal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + | 6 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + | 6 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + | 6 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + + M + M | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + | 6 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + M | 5 |
Ectasia | 4 1 4 1 3 | 5 2.6|
__________________________________________________________________________|____________|
Prostate | + + + + + + | 6 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + | 6 |
__________________________________________________________________________|____________|
Testes | + + + + + + | 6 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1| 4| 1| 4| 1| 1| 0| 4| 1| 1| | |
DAY ON TEST | 7| 7| 9| 9| 7| 9| 9| 7| 7| 7| 9| 7| 9| 7| 9| 9| 3| 7| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.6MG/M3 | 6| 6| 6| 7| 7| 7| 7| 8| 9| 9| 9| 0| 0| 0| 1| 1| 2| 3| 3| 3| | L |
LUNG TOX | 1| 5| 7| 2| 4| 5| 9| 7| 2| 3| 8| 2| 3| 8| 3| 5| 3| 0| 5| 9| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node | + + | 2 |
Inguinal, Hyperplasia, Lymphoid | 4 | 1 4.0|
Lumbar, Hyperplasia, Lymphoid | 2 | 1 2.0|
Lumbar, Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + I + + + I I + + M + | 7 |
Hyperplasia, Lymphoid | 1 1 2 2 1 | 5 1.4|
Hyperplasia, Macrophage | 1 1 1 1 2 | 5 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | M + M + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + | 6 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | M M M + M + M I + M M | 3 |
Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + | 6 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + M + + | 5 |
Degeneration | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + | 6 |
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + | 6 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
Degeneration, Secondary Wallerian | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + I + + + | 5 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + | 11 |
Inflammation, Chronic Active | 2 1 2 1 1 1 1 1 | 8 1.3|
Alveolar Epithelium, Hyperplasia | 1 2 1 2 | 4 1.5|
Alveolus, Hyperplasia, Macrophage | 1 2 1 2 1 1 1 1 1 1 | 10 1.2|
Alveolus, Proteinosis | 4 3 1 4 1 1 3 3 1 1 | 10 2.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 73
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 4| 4| 1| 1| 4| 1| 1| 4| 4| 4| 1| 4| 1| 4| 1| 1| 0| 4| 1| 1| | |
DAY ON TEST | 7| 7| 9| 9| 7| 9| 9| 7| 7| 7| 9| 7| 9| 7| 9| 9| 3| 7| 9| 9| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 6| 5| 6| 6| 6| 6| 6| 6| 7| 6| 6| 6| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | A |
0.6MG/M3 | 6| 6| 6| 7| 7| 7| 7| 8| 9| 9| 9| 0| 0| 0| 1| 1| 2| 3| 3| 3| | L |
LUNG TOX | 1| 5| 7| 2| 4| 5| 9| 7| 2| 3| 8| 2| 3| 8| 3| 5| 3| 0| 5| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Bronchus, Hyperplasia, Lymphoid | 1 | 1 1.0|
Interstitium, Infiltration Cellular | 1 2 1 3 1 1 1 1 1 1 | 10 1.3|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + | 11 |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 | 5 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + | 11 |
Hydronephrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Concretion | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 7 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 74
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 4| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 4| 7|
DAY ON TEST | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 7| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 7| 3|
| 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + M M + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + A + + A + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + A + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + A + + + + + + + + +|
Peyer's Patch, Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 3 |
Atrophy | 3 |
Basophilic Focus | X |
Infarct | 4 4 |
Mixed Cell Focus | |
Necrosis | 3 |
Pigmentation, Hemosiderin | |
Sinusoid, Cyst | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + A + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + A + + + + + + + + +|
Degeneration | |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | X |
Inflammation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + M + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1|
__________________________________________________________________________|
Adrenal Medulla | + M + + + + + + + + + + M + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M + + + + + + + + + + + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + I + + + + + + + + +|
Pars Distalis, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 2 1 1 1 1 1 1 2 1 1 1 1|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 75
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 4| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 4| 7|
DAY ON TEST | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 7| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 7| 3|
| 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + |
Concretion | |
Inflammation | 3 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Ectasia | 1 3 3 3 3 3 3 3 4 3 3 3 2 4 2 2 3 2|
Inflammation, Chronic | 4 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | 3 |
Erythroid Cell, Hyperplasia | 3 |
Myeloid Cell, Hyperplasia | 3 3 3 3 3 2 |
__________________________________________________________________________|
Lymph Node | + + + |
Iliac, Hyperplasia, Lymphoid | 3 |
Iliac, Hyperplasia, Plasma Cell | 3 |
Iliac, Pigmentation | 2 |
Inguinal, Hyperplasia, Lymphoid | 2 |
__________________________________________________________________________|
Lymph Node, Bronchial | I I M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 2 2 4 2 1 4 2 1 1 2 2 1 2 3 2 1 3|
Hyperplasia, Macrophage | 2 2 1 2 2 1 2 2 2 2 2 2 1 1 2 2 2 1 2|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + +|
Hyperplasia, Lymphoid | 4 4 3 3 2|
__________________________________________________________________________|
Lymph Node, Mediastinal | I M M M I + M I + I I + + + + + M I + M I M M|
Hyperplasia, Lymphoid | |
Hyperplasia, Macrophage | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 3 4 |
Hyperplasia, Lymphoid | 1 2 |
_____________________________________________________________________________________________________________________|
Page 76
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 4| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 4| 7|
DAY ON TEST | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 7| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 7| 3|
| 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation | 3 |
__________________________________________________________________________|
Thymus | M + + M M I + + M M M + M + + M I M + + + + +|
Degeneration | 4 3 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | 2 |
Inflammation | 4 |
Prepuce, Hyperkeratosis | |
Prepuce, Inflammation | 4 4 4 4 |
Tail, Inflammation | 4 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + +|
Autolysis | 3 |
Fibrosis | 1 1 1|
Inflammation, Acute | 1 1 |
Inflammation, Chronic Active | 1 2 3 3 2 2 2 2 2 3 2 2 1 3 1 3 2 1 1 1|
Alveolar Epithelium, Hyperplasia | 2 2 2 3 2 2 2 2 3 2 2 2 1 2 3 2 2 1 3 3 3|
Alveolar Epithelium, Metaplasia, | |
Squamous | 1 |
Alveolus, Hyperplasia, Macrophage | 2 2 2 4 3 3 4 3 3 1 3 3 2 2 2 2 2 3 2 2 2 3 2|
Alveolus, Hyperplasia | 2 |
Alveolus, Proteinosis | 3 3 4 1 2 4 1 4 2 1 1 3 4 2 3 4 3 3 4 3 4 3 4|
Bronchus, Hyperplasia, Lymphoid | 3 2 2 2 1 |
Interstitium, Infiltration Cellular | 1 1 1 3 3 2 3 2 1 4 1 1 1 1 2 1 2 1 1 2 2 2|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Acute | 1 |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 1 1 2 2 1 2 1 1 1 1 1 1 1 1 1|
Olfactory Epithelium, Degeneration | 1 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 77
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 4| 3| 7| 7| 7| 7| 7| 7| 6| 1| 7| 4| 7| 6| 7| 4| 7| 4| 7| 6| 4| 7| 7| 4| 7|
DAY ON TEST | 5| 7| 4| 4| 3| 3| 3| 4| 0| 4| 3| 7| 1| 6| 0| 8| 1| 5| 3| 9| 6| 4| 4| 7| 3|
| 9| 4| 1| 0| 7| 7| 7| 1| 7| 4| 7| 6| 6| 5| 5| 5| 1| 0| 7| 5| 3| 0| 1| 6| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|
| 2| 3| 4| 5| 7| 8| 9| 0| 1| 3| 4| 5| 6| 7| 9| 0| 2| 3| 4| 5| 6| 7| 8| 9| 0|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 2 3 3 |
Infiltration Cellular, Lymphocyte | 1 |
Inflammation | |
Nephropathy | 1 |
Cortex, Fibrosis | |
Pelvis, Inflammation | 3 |
Renal Tubule, Atrophy | |
Renal Tubule, Necrosis | |
__________________________________________________________________________|
Urethra | + + + + + + |
Calculus Micro Observation Only | X |
Concretion | 3 3 3 3 |
Inflammation | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | X |
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
Page 78
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 0| 4| 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3|
| 7| 0| 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + A + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + A + + M + + + M + + + + + + M + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Tissue, Hyperplasia, | |
Lymphoid | 3 4 3 |
__________________________________________________________________________|
Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + A + + + + + M + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + + + + + + A|
Peyer's Patch, Hyperplasia, Lymphoid | 3 3 |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Atrophy | |
Basophilic Focus | |
Infarct | |
Mixed Cell Focus | X |
Necrosis | 3 2 1 |
Pigmentation, Hemosiderin | |
Sinusoid, Cyst | X |
__________________________________________________________________________|
Pancreas | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Glandular | + + + A + + + + + + + + + + + + + + + + + + + + +|
Degeneration | 3 |
__________________________________________________________________________|
Tooth | + |
Developmental Malformation | |
Inflammation | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
__________________________________________________________________________|
Adrenal Medulla | + + + M + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + A + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + M + + + M + + + + M + M + + + M + M +|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Follicular Cell, Hyperplasia | 1 1 1 1 1 1 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 79
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 0| 4| 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3|
| 7| 0| 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Coagulating Gland | |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Penis | + + + + |
Concretion | 4 |
Inflammation | 4 4 2 |
__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Ectasia | 3 2 2 3 2 3 2 3 3 3 2 3 3 3 2 3|
Inflammation, Chronic | 2 3 3 3 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation | 2 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | A |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Thrombosis | |
Erythroid Cell, Hyperplasia | |
Myeloid Cell, Hyperplasia | 2 3 3 2 3 3 |
__________________________________________________________________________|
Lymph Node | + + + + + + |
Iliac, Hyperplasia, Lymphoid | 4 3 |
Iliac, Hyperplasia, Plasma Cell | 3 3 |
Iliac, Pigmentation | |
Inguinal, Hyperplasia, Lymphoid | 3 2 3 4 |
__________________________________________________________________________|
Lymph Node, Bronchial | + + + + + + + + + + + + + + + + + + I + + + + + +|
Hyperplasia, Lymphoid | 1 4 3 3 1 4 3 1 4 1 3 1 1 1 2 3 4 3 4 3 2 2|
Hyperplasia, Macrophage | 2 2 2 2 2 1 2 2 2 3 2 1 2 2 2 1 1 1 1 2 2 2 3|
__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M M + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + A + M + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | |
__________________________________________________________________________|
Lymph Node, Mediastinal | M M M M M I A M M + M I + M + M I M I + + + + I +|
Hyperplasia, Lymphoid | 3 |
Hyperplasia, Macrophage | 1|
__________________________________________________________________________|
Spleen | + + + A + + + + + + + + + + + + + + M + + + + + +|
Atrophy | |
Hematopoietic Cell Proliferation | 2 2 |
Hyperplasia, Lymphoid | 2 2 2 1 |
_____________________________________________________________________________________________________________________|
Page 80
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 0| 4| 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3|
| 7| 0| 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Inflammation | |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + M + M + I + + + + + + + +|
Degeneration | 2 3 3 3 2 2 3 3 3 2 3|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Alopecia | |
Inflammation | 4 |
Prepuce, Hyperkeratosis | 3 |
Prepuce, Inflammation | 3 3 4 4 4 4 3 4|
Tail, Inflammation | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lung | + + + A + + + + + + + + + + + + + + + + + + + + +|
Autolysis | |
Fibrosis | 1 1 1 1 1 1 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 3 1 1 3 2 1 2 2 1 3 1 1 2 2 2 2 3 2 3 2 2 2|
Alveolar Epithelium, Hyperplasia | 2 2 3 2 1 2 2 2 3 1 2 2 2 2 2 3 2 2 2 2 2 2 2 2|
Alveolar Epithelium, Metaplasia, | |
Squamous | |
Alveolus, Hyperplasia, Macrophage | 2 3 2 2 3 2 3 2 3 2 3 2 3 2 2 3 2 2 4 4 3 3 2 3|
Alveolus, Hyperplasia | |
Alveolus, Proteinosis | 3 3 3 3 2 4 4 3 2 4 1 2 3 4 4 3 2 4 2 3 3 3 3 3|
Bronchus, Hyperplasia, Lymphoid | 3 2 2 1 1 1 1 |
Interstitium, Infiltration Cellular | 1 2 2 1 4 1 1 2 2 1 3 2 2 2 1 3 1 3 3 2 2 1 1|
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Inflammation, Acute | |
Olfactory Epithelium, Atrophy | 1 2 2 1 2 2 1 1 2 2 1 1 1 1 1 1 1 1 2 1 1 1 1 1 2|
Olfactory Epithelium, Degeneration | 1 1 |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 81
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
_____________________________________________________________________________________________________________________
| 6| 7| 6| 2| 5| 7| 3| 6| 6| 7| 4| 7| 6| 6| 5| 4| 7| 6| 6| 7| 7| 7| 7| 6| 5|
DAY ON TEST | 0| 4| 6| 5| 8| 4| 8| 4| 6| 3| 2| 4| 6| 4| 2| 6| 3| 6| 2| 4| 4| 3| 3| 6| 3|
| 7| 0| 1| 0| 5| 0| 5| 2| 1| 4| 4| 0| 5| 4| 4| 9| 7| 6| 6| 0| 0| 7| 7| 1| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
1.2MG/M3 | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|
| 1| 2| 3| 6| 9| 1| 2| 3| 5| 6| 8| 0| 1| 2| 4| 6| 8| 9| 0| 1| 2| 3| 4| 5| 6|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydronephrosis | 1 2 |
Infiltration Cellular, Lymphocyte | 2 |
Inflammation | 3 |
Nephropathy | 1 1 1 1 |
Cortex, Fibrosis | |
Pelvis, Inflammation | 3 |
Renal Tubule, Atrophy | |
Renal Tubule, Necrosis | 2 |
__________________________________________________________________________|
Urethra | + + + + |
Calculus Micro Observation Only | |
Concretion | 3 3 3 3 |
Inflammation | |
__________________________________________________________________________|
Urinary Bladder | + + + A + + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation | 4 2 |
_____________________________________________________________________________________________________________________|
Page 82
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 5| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 3| 4| 1| 3| 3| 4| 7| 3| | |
| 7| 5| 7| 0| 3| 9| 7| 0| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
1.2MG/M3 | 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 7| 9| 1| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 58 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + A + | 55 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + + + + + A M | 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + A + | 54 |
Lymphoid Tissue, Hyperplasia, | | |
Lymphoid | | 3 3.3|
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + A + | 53 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + A + | 54 |
Peyer's Patch, Hyperplasia, Lymphoid | | 3 3.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + A + | 57 |
Angiectasis | | 1 3.0|
Atrophy | 3 | 2 3.0|
Basophilic Focus | | 1 |
Infarct | | 2 4.0|
Mixed Cell Focus | | 1 |
Necrosis | 3 | 5 2.4|
Pigmentation, Hemosiderin | 3 | 1 3.0|
Sinusoid, Cyst | | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + A + | 56 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + A + | 55 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + A + | 55 |
Degeneration | | 1 3.0|
__________________________________________________________________________|____________|
Tooth | + + | 4 |
Developmental Malformation | X | 2 |
Inflammation | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 58 |
Angiectasis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + A + | 56 |
Hyperplasia, Focal | 2 | 4 2.0|
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + A + | 54 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + A + | 56 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + A + | 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 5| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 3| 4| 1| 3| 3| 4| 7| 3| | |
| 7| 5| 7| 0| 3| 9| 7| 0| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
1.2MG/M3 | 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 7| 9| 1| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + A M | 53 |
Pars Distalis, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + A + | 57 |
Follicular Cell, Hyperplasia | 1 2 1 1 1 | 24 1.2|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Coagulating Gland | + | 1 |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Penis | + | 8 |
Concretion | | 1 4.0|
Inflammation | 4 | 6 3.2|
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 58 |
Atrophy | | 1 2.0|
Ectasia | 4 3 3 2 2 3 2 | 41 2.7|
Inflammation, Chronic | 3 3 | 7 3.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + A + | 57 |
Inflammation | | 2 2.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Testes | + + + + + + + + A + | 57 |
Atrophy | 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + A + | 57 |
Thrombosis | | 1 3.0|
Erythroid Cell, Hyperplasia | | 1 3.0|
Myeloid Cell, Hyperplasia | 2 3 | 14 2.7|
__________________________________________________________________________|____________|
Lymph Node | + | 10 |
Iliac, Hyperplasia, Lymphoid | | 3 3.3|
Iliac, Hyperplasia, Plasma Cell | | 3 3.0|
Iliac, Pigmentation | | 1 2.0|
Inguinal, Hyperplasia, Lymphoid | 4 | 6 3.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + A + | 53 |
Hyperplasia, Lymphoid | 1 1 1 3 2 2 2 4 2 | 49 2.2|
Hyperplasia, Macrophage | 2 2 2 2 2 2 2 | 49 1.8|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + A + | 55 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 5| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 3| 4| 1| 3| 3| 4| 7| 3| | |
| 7| 5| 7| 0| 3| 9| 7| 0| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
1.2MG/M3 | 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 7| 9| 1| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Hyperplasia, Lymphoid | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + A + | 53 |
Hyperplasia, Lymphoid | 3 | 6 3.2|
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | I M I I M + I I A M | 17 |
Hyperplasia, Lymphoid | | 1 3.0|
Hyperplasia, Macrophage | | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + A + | 55 |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 3 | 5 2.8|
Hyperplasia, Lymphoid | 2 | 7 1.7|
Inflammation | | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M M + + + M + + A + | 39 |
Degeneration | 3 | 15 2.7|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + + A + | 57 |
Alopecia | | 1 2.0|
Inflammation | | 2 4.0|
Prepuce, Hyperkeratosis | | 1 3.0|
Prepuce, Inflammation | 4 | 13 3.8|
Tail, Inflammation | | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + A + | 57 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + A + | 57 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + + + + A + | 57 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + A + | 56 |
Autolysis | | 1 3.0|
Fibrosis | 1 1 1 1 1 | 15 1.0|
Inflammation, Acute | | 2 1.0|
Inflammation, Chronic Active | 2 2 2 2 3 2 2 3 1 | 52 2.0|
Alveolar Epithelium, Hyperplasia | 3 2 2 2 2 2 2 3 3 | 54 2.1|
Alveolar Epithelium, Metaplasia, | | |
Squamous | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 7| 3| 7| 7| 7| 5| 7| 7| 6| 7| | |
DAY ON TEST | 3| 3| 3| 4| 1| 3| 3| 4| 7| 3| | |
| 7| 5| 7| 0| 3| 9| 7| 0| 6| 7| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A |
1.2MG/M3 | 8| 8| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 7| 9| 1| 3| 4| 5| 6| 7| 8| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Hyperplasia, Macrophage | 4 1 3 4 3 2 3 3 2 | 56 2.6|
Alveolus, Hyperplasia | | 1 2.0|
Alveolus, Proteinosis | 3 4 3 3 2 3 4 3 4 | 56 3.0|
Bronchus, Hyperplasia, Lymphoid | 1 1 | 14 1.6|
Interstitium, Infiltration Cellular | 2 3 2 2 2 2 2 2 | 53 1.8|
__________________________________________________________________________|____________|
Nose | + + + + + + + + A + | 57 |
Foreign Body | 2 | 1 2.0|
Inflammation, Acute | 2 3 | 3 2.0|
Olfactory Epithelium, Atrophy | 1 1 1 2 1 1 1 1 | 54 1.2|
Olfactory Epithelium, Degeneration | 1 | 6 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + M + + M + | 56 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + A + | 57 |
Hydronephrosis | | 5 2.2|
Infiltration Cellular, Lymphocyte | | 2 1.5|
Inflammation | | 1 3.0|
Nephropathy | 1 | 6 1.0|
Cortex, Fibrosis | 2 | 1 2.0|
Pelvis, Inflammation | | 2 3.0|
Renal Tubule, Atrophy | 4 | 1 4.0|
Renal Tubule, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Urethra | + | 11 |
Calculus Micro Observation Only | X | 2 |
Concretion | | 8 3.0|
Inflammation | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + A + | 56 |
Calculus Micro Observation Only | X | 2 |
Inflammation | | 3 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 1| 4| 4| 1| 4| 4| 1| 1| 3| 4| 1| 4| 1| 1| 1| 4| 1| 4| 1| 1| | |
DAY ON TEST | 9| 7| 7| 9| 7| 7| 9| 9| 9| 7| 9| 7| 9| 9| 9| 7| 9| 7| 9| 1| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.2MG/M3 | 2| 2| 3| 3| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9| | L |
LUNG TOX | 1| 6| 2| 8| 1| 4| 5| 7| 8| 0| 4| 7| 9| 3| 5| 7| 8| 0| 2| 9| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Gallbladder | + A + + + M + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | M M + + + + + | 5 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + | 6 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + | 6 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 7 |
Basophilic Focus | X | 1 |
Mixed Cell Focus | X | 1 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + M M | 3 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + | 7 |
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + | 7 |
Ectasia | 2 2 4 1 | 4 2.3|
Inflammation, Chronic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Prostate | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 87
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 1| 4| 4| 1| 4| 4| 1| 1| 3| 4| 1| 4| 1| 1| 1| 4| 1| 4| 1| 1| | |
DAY ON TEST | 9| 7| 7| 9| 7| 7| 9| 9| 9| 7| 9| 7| 9| 9| 9| 7| 9| 7| 9| 1| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.2MG/M3 | 2| 2| 3| 3| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9| | L |
LUNG TOX | 1| 6| 2| 8| 1| 4| 5| 7| 8| 0| 4| 7| 9| 3| 5| 7| 8| 0| 2| 9| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + | 7 |
Myeloid Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Inguinal, Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node, Bronchial | + + + + + + + + + + + M | 11 |
Hyperplasia, Lymphoid | 1 2 2 1 4 1 2 1 | 8 1.8|
Hyperplasia, Macrophage | 1 1 2 1 1 1 2 1 1 1 | 10 1.2|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M + + M + + + | 6 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + | 7 |
__________________________________________________________________________|____________|
Lymph Node, Mediastinal | + M A M + + I I M + + M | 5 |
__________________________________________________________________________|____________|
Spleen | + + + + + + + | 7 |
Hyperplasia, Lymphoid | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + | 7 |
Degeneration | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M M | |
__________________________________________________________________________|____________|
Skin | + + + + + + + | 7 |
Subcutaneous Tissue, Abscess | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + | 7 |
Femur, Hyperostosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + | 7 |
Medulla, Degeneration, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Larynx | + + + + + I + | 6 |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + | 12 |
Fibrosis | 1 | 1 1.0|
Inflammation, Chronic Active | 2 2 2 2 2 2 2 1 1 1 2 | 11 1.7|
Alveolar Epithelium, Hyperplasia | 2 2 3 3 3 | 5 2.6|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 88
NTP Experiment-Test: 05107-06 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC NICKEL SUBSULFIDE Date: 04/18/97
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 12:19:00
__________________________________________________________________________________________________________________________________
| 1| 4| 4| 1| 4| 4| 1| 1| 3| 4| 1| 4| 1| 1| 1| 4| 1| 4| 1| 1| | |
DAY ON TEST | 9| 7| 7| 9| 7| 7| 9| 9| 9| 7| 9| 7| 9| 9| 9| 7| 9| 7| 9| 1| | |
| 6| 6| 6| 6| 6| 6| 6| 6| 1| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | A |
1.2MG/M3 | 2| 2| 3| 3| 4| 5| 5| 5| 5| 6| 6| 6| 6| 7| 7| 7| 8| 9| 9| 9| | L |
LUNG TOX | 1| 6| 2| 8| 1| 4| 5| 7| 8| 0| 4| 7| 9| 3| 5| 7| 8| 0| 2| 9| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Alveolus, Hyperplasia, Macrophage | 1 1 2 2 3 2 2 3 1 2 1 1 | 12 1.8|
Alveolus, Proteinosis | 2 2 3 3 4 2 2 3 1 3 1 | 11 2.4|
Bronchus, Hyperplasia, Lymphoid | 1 1 | 2 1.0|
Interstitium, Infiltration Cellular | 1 2 1 1 1 1 2 1 1 1 | 10 1.2|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + | 12 |
Olfactory Epithelium, Atrophy | 1 1 1 1 1 1 1 1 1 | 9 1.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + | 7 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + | 12 |
Inflammation | 4 | 1 4.0|
Nephropathy | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urethra | + | 1 |
Calculus Micro Observation Only | X | 1 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + | 7 |
Calculus Gross Observation | X | 1 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 89
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---------- END OF REPORT ----------
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