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TDMS Study 05110-02 Pathology Tables

NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03

                                                    CORE STUDY RATS/FINAL#3




       Facility:  Battelle Northwest

       Chemical CAS #:  91-20-3

       Lock Date:  01/05/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      10 PPM       30 PPM       60 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          49           49           49           49                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           22           16           21                                     
    Natural Death                                      3            6            5            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           21           28           24                                     
                                                                                                                                    
  Animals Examined Microscopically                    49           49           49           49                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (49)         (49)         (49)                                   
   Intestine Small, Jejunum                           (49)         (48)         (48)         (46)                                   
   Intestine Small, Ileum                             (49)         (48)         (47)         (46)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
   Liver                                              (49)         (49)         (49)         (49)                                   
      Hepatocellular Carcinoma                                      1 (2%)       1 (2%)                                             
   Mesentery                                          (13)         (8)          (7)          (5)                                    
   Pancreas                                           (49)         (49)         (49)         (49)                                   
   Salivary Glands                                    (49)         (49)         (49)         (49)                                   
      Adenoma                                                                                 1 (2%)                                
   Stomach, Forestomach                               (49)         (49)         (49)         (49)                                   
   Stomach, Glandular                                 (49)         (48)         (49)         (49)                                   
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
   Tongue                                             (1)          (1)                       (1)                                    
      Squamous Cell Papilloma                                                                 1 (100%)                              
      Epithelium, Squamous Cell Papilloma                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (49)         (49)         (49)                                   
      Schwannoma Benign                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   2                                                               
                                                                                                                                   
NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      10 PPM       30 PPM       60 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (49)         (49)         (49)                                   
      Adenoma                                          1 (2%)       2 (4%)       1 (2%)                                             
   Adrenal Medulla                                    (48)         (49)         (49)         (49)                                   
      Pheochromocytoma Benign                          2 (4%)                    1 (2%)       2 (4%)                                
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (49)         (49)         (49)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma                                        1 (2%)                                                                       
   Parathyroid Gland                                  (42)         (40)         (41)         (48)                                   
   Pituitary Gland                                    (49)         (49)         (49)         (48)                                   
      Pars Distalis, Adenoma                          23 (47%)     27 (55%)     24 (49%)     20 (42%)                               
      Pars Distalis, Carcinoma                                                   1 (2%)                                             
   Thyroid Gland                                      (47)         (46)         (48)         (48)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  4 (9%)       3 (7%)       2 (4%)       1 (2%)                                
      C-Cell, Carcinoma                                3 (6%)       2 (4%)       2 (4%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (49)         (47)         (49)         (48)                                   
      Adenoma                                          3 (6%)       7 (15%)      4 (8%)       2 (4%)                                
      Carcinoma                                                     1 (2%)       1 (2%)       1 (2%)                                
      Bilateral, Adenoma                               1 (2%)                                                                       
   Ovary                                              (49)         (49)         (49)         (49)                                   
      Granulosa Cell Tumor Malignant                   2 (4%)       2 (4%)                                                          
      Granulosa-Theca Tumor Malignant                  1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
   Uterus                                             (49)         (49)         (49)         (49)                                   
      Carcinoma                                                                  1 (2%)                                             
      Polyp Stromal                                   14 (29%)      5 (10%)      8 (16%)      7 (14%)                               
      Bilateral, Polyp Stromal                         1 (2%)       2 (4%)       1 (2%)                                             
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                                                             Page   3                                                               
                                                                                                                                   
NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      10 PPM       30 PPM       60 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (49)         (49)                                   
   Lymph Node                                         (2)          (3)          (2)          (3)                                    
   Lymph Node, Bronchial                              (42)         (33)         (34)         (36)                                   
   Lymph Node, Mandibular                             (47)         (39)         (46)         (47)                                   
   Lymph Node, Mesenteric                             (49)         (49)         (49)         (49)                                   
   Lymph Node, Mediastinal                            (40)         (39)         (41)         (31)                                   
   Spleen                                             (49)         (49)         (49)         (49)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Thymus                                             (46)         (45)         (48)         (41)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (49)         (49)         (49)                                   
      Carcinoma                                        3 (6%)       5 (10%)      3 (6%)       3 (6%)                                
      Fibroadenoma                                    14 (29%)     16 (33%)     17 (35%)     10 (20%)                               
      Fibroadenoma, Multiple                           3 (6%)       4 (8%)       1 (2%)       4 (8%)                                
   Skin                                               (49)         (49)         (49)         (49)                                   
      Basal Cell Adenoma                                                         1 (2%)                                             
      Keratoacanthoma                                                                         1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                               1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                                                       1 (2%)                                
      Subcutaneous Tissue, Hemangioma                  1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (49)         (49)         (49)                                   
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                                 (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (49)         (49)         (49)                                   
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                             
      Glioma Malignant                                                           1 (2%)                                             
      Neuroblastoma, Metastatic, Nose                               1 (2%)                    4 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   4                                                               
                                                                                                                                   
NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      10 PPM       30 PPM       60 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (49)         (49)         (49)                                   
   Lung                                               (49)         (49)         (49)         (49)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Nose                                               (49)         (49)         (49)         (49)                                   
      Olfactory Epithelium, Neuroblastoma                           2 (4%)       3 (6%)      12 (24%)                               
      Respiratory Epithelium, Adenoma                                            4 (8%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (2)          (1)                                                              
      Carcinoma                                        2 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (48)         (49)         (49)         (49)                                   
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
   Urinary Bladder                                    (48)         (49)         (49)         (49)                                   
      Transitional Epithelium, Papilloma               1 (2%)                    1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(49)        *(49)        *(49)        *(49)                                   
      Leukemia Mononuclear                            16 (33%)     21 (43%)     15 (31%)     15 (31%)                               
      Mesothelioma Benign                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   5                                                               
                                                                                                                                   
NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      10 PPM       30 PPM       60 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            44          48          47          44                                       
     Total Primary Neoplasms                          104         105          97          85                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 38          41          43          35                                       
     Total Benign Neoplasms                            72          69          69          53                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          34          26          27                                       
     Total Malignant Neoplasms                         32          36          28          32                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          4           1           4                                       
     Total Metastatic Neoplasm                                      8           1           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   6                                                               
                                                                                                                                   
NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      10 PPM       30 PPM       60 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
                                                                                                                                    
  Animals Initially in Study                          49           49           49           49                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           22           19           25                                     
    Natural Death                                      4            5            6            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           22           23           21                                     
  Other                                                                          1                                                  
                                                                                                                                    
  Animals Examined Microscopically                    49           49           48           49                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (48)         (48)                                   
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Large, Cecum                             (46)         (49)         (47)         (48)                                   
   Intestine Small, Jejunum                           (45)         (47)         (43)         (47)                                   
      Carcinoma                                                                               1 (2%)                                
      Leiomyosarcoma                                                                          1 (2%)                                
   Intestine Small, Ileum                             (45)         (47)         (45)         (47)                                   
   Liver                                              (49)         (49)         (48)         (49)                                   
      Hepatocellular Carcinoma                         1 (2%)                                 1 (2%)                                
      Hepatocellular Adenoma                           1 (2%)                                 3 (6%)                                
   Mesentery                                          (13)         (6)          (9)          (8)                                    
      Hemangiosarcoma                                                                         1 (13%)                               
      Sarcoma                                          1 (8%)                                                                       
   Pancreas                                           (49)         (49)         (48)         (49)                                   
      Adenoma                                          1 (2%)                                 2 (4%)                                
      Carcinoma                                                                               1 (2%)                                
      Mixed Tumor Benign                                                         1 (2%)                                             
   Salivary Glands                                    (49)         (49)         (47)         (49)                                   
   Stomach, Forestomach                               (49)         (49)         (48)         (49)                                   
   Stomach, Glandular                                 (49)         (49)         (48)         (49)                                   
   Tongue                                                          (1)          (1)                                                 
      Squamous Cell Carcinoma                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   7                                                               
                                                                                                                                   
NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      10 PPM       30 PPM       60 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (49)         (48)         (49)                                   
      Schwannoma Benign                                             1 (2%)       2 (4%)                                             
      Schwannoma Malignant, Metastatic, Skin                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (49)         (49)         (48)         (49)                                   
      Adenoma                                          2 (4%)                    1 (2%)       2 (4%)                                
   Adrenal Medulla                                    (49)         (49)         (47)         (49)                                   
      Pheochromocytoma Malignant                       1 (2%)       3 (6%)       1 (2%)       1 (2%)                                
      Pheochromocytoma Benign                          4 (8%)       6 (12%)      6 (13%)      8 (16%)                               
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (49)         (49)         (48)         (49)                                   
      Adenoma                                          2 (4%)       5 (10%)      3 (6%)       2 (4%)                                
      Carcinoma                                        4 (8%)       4 (8%)       4 (8%)       4 (8%)                                
   Pituitary Gland                                    (49)         (49)         (47)         (49)                                   
      Pars Distalis, Adenoma                          31 (63%)     31 (63%)     35 (74%)     29 (59%)                               
   Thyroid Gland                                      (46)         (47)         (45)         (47)                                   
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  9 (20%)      5 (11%)      4 (9%)       4 (9%)                                
      C-Cell, Carcinoma                                1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (49)         (48)         (49)                                   
   Preputial Gland                                    (48)         (49)         (47)         (49)                                   
      Adenoma                                          3 (6%)                    1 (2%)       1 (2%)                                
      Carcinoma                                        3 (6%)       1 (2%)       1 (2%)       1 (2%)                                
   Prostate                                           (49)         (49)         (48)         (49)                                   
   Seminal Vesicle                                    (47)         (49)         (47)         (47)                                   
      Carcinoma                                                                  1 (2%)                                             
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   8                                                               
                                                                                                                                   
NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      10 PPM       30 PPM       60 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Testes                                             (49)         (49)         (48)         (49)                                   
      Bilateral, Interstitial Cell, Adenoma           24 (49%)     22 (45%)     19 (40%)     20 (41%)                               
      Interstitial Cell, Adenoma                      14 (29%)     10 (20%)     17 (35%)     11 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)         (48)         (49)                                   
   Lymph Node                                         (3)          (3)          (8)          (4)                                    
   Lymph Node, Bronchial                              (29)         (36)         (38)         (35)                                   
   Lymph Node, Mandibular                             (40)         (45)         (46)         (44)                                   
   Lymph Node, Mesenteric                             (47)         (49)         (48)         (49)                                   
   Lymph Node, Mediastinal                            (24)         (28)         (44)         (41)                                   
   Spleen                                             (49)         (49)         (48)         (49)                                   
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
   Thymus                                             (47)         (46)         (43)         (46)                                   
      Schwannoma Malignant, Metastatic, Skin                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (21)         (20)         (30)         (28)                                   
      Carcinoma                                        1 (5%)       1 (5%)       1 (3%)                                             
      Fibroadenoma                                                                            3 (11%)                               
   Skin                                               (48)         (48)         (48)         (48)                                   
      Basal Cell Adenoma                                            1 (2%)       2 (4%)                                             
      Keratoacanthoma                                  4 (8%)       3 (6%)       2 (4%)       2 (4%)                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Sebaceous Gland, Adenoma                         1 (2%)       1 (2%)                    1 (2%)                                
      Sebaceous Gland, Carcinoma                                                 1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     5 (10%)      2 (4%)       2 (4%)       2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       1 (2%)                    2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma, Multiple                   1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                      1 (2%)       1 (2%)       3 (6%)                                             
      Subcutaneous Tissue, Neural Crest Tumor                                                 1 (2%)                                
      Subcutaneous Tissue, Sarcoma                                  1 (2%)       2 (4%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page   9                                                               
                                                                                                                                   
NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      10 PPM       30 PPM       60 PPM                                    
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (49)         (48)         (49)                                   
      Osteosarcoma                                     1 (2%)       1 (2%)                                                          
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 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (49)         (48)         (49)                                   
      Neuroblastoma, Metastatic, Nose                                                         2 (4%)                                
   Spinal Cord                                                     (1)                                                              
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 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (49)         (49)         (48)         (49)                                   
      Schwannoma Malignant, Metastatic, Skin                                     1 (2%)                                             
   Lung                                               (49)         (49)         (48)         (49)                                   
      Alveolar/Bronchiolar Adenoma                     2 (4%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                3 (6%)                                                          
      Carcinoma, Metastatic, Preputial Gland           1 (2%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland                                      1 (2%)       1 (2%)                                
      Neuroblastoma, Metastatic, Nose                                            1 (2%)       1 (2%)                                
      Osteosarcoma, Metastatic, Bone                   1 (2%)       1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)       1 (2%)       1 (2%)                                             
      Schwannoma Malignant, Metastatic, Skin                                     1 (2%)                                             
   Nose                                               (49)         (49)         (48)         (48)                                   
      Olfactory Epithelium, Neuroblastoma                                        4 (8%)       3 (6%)                                
      Respiratory Epithelium, Adenoma                               6 (12%)      8 (17%)     15 (31%)                               
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 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (48)         (48)         (48)         (48)                                   
   Zymbal's Gland                                                               (1)          (1)                                    
      Carcinoma                                                                  1 (100%)                                           
      Bilateral, Carcinoma                                                                    1 (100%)                              
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                                                             Page  10                                                               
                                                                                                                                   
NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03  
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         FISCHER 344 RATS MALE                     CONTROL      10 PPM       30 PPM       60 PPM                                    
                                                                                                                                    
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 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (49)         (48)         (49)                                   
      Schwannoma Malignant, Metastatic, Skin                                     1 (2%)                                             
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
   Urinary Bladder                                    (48)         (49)         (48)         (49)                                   
      Transitional Epithelium, Papilloma               1 (2%)                                 2 (4%)                                
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   
                                                                                                                                    
   Multiple Organs                                   *(49)        *(49)        *(48)        *(49)                                   
      Leukemia Mononuclear                            26 (53%)     21 (43%)     24 (50%)     17 (35%)                               
      Mesothelioma Benign                              2 (4%)                    1 (2%)       1 (2%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  11                                                               
                                                                                                                                   
NTP Experiment-Test: 05110-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 08/15/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 08:28:03  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      10 PPM       30 PPM       60 PPM                                    
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          49          48          49                                       
     Total Primary Neoplasms                          149         139         152         146                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          47          47          47                                       
     Total Benign Neoplasms                           107          96         110         108                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              34          32          34          32                                       
     Total Malignant Neoplasms                         42          43          42          37                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           3           4           3                                       
     Total Metastatic Neoplasm                          4           3           8           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      1                                       
     Total Uncertain Neoplasms                                                              1                                       
                                                                                                                                    
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                             Page  12                                                               
                                                                                                                                   
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