Share This:
https://ntp.niehs.nih.gov/go/929

TDMS Study 05110-02 Pathology Tables

NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03

                                                    FINAL#2, CORE STUDY RATS




       Facility:  Battelle Northwest

       Chemical CAS #:  91-20-3

       Lock Date:  01/05/99

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































                                                              Page   1



NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 7| 2| 7| 0| 3| 3| 3| 3| 3| 7| 1| 7| 3| 5| 3|             
                                           | 4| 4| 5| 4| 6| 4| 5| 4| 5| 5| 9| 7| 6| 2| 6| 5| 6| 5| 5| 7| 3| 1| 5| 7| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    3                     |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X     X|             
      Clear Cell Focus                     |                            X                                      X      |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change                         |                               2  2        2                 1        2   |             
      Hepatodiaphragmatic Nodule           |                               X     X  X              X                  |             
      Inflammation, Chronic                |                                                             2            |             
      Mixed Cell Focus                     |                                           X                              |             
      Necrosis                             |                                           2                              |             
      Regeneration                         |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       3                                                                  |             
      Bile Duct, Hyperplasia               |                                  2     1                             2   |             
      Centrilobular, Necrosis              |                               1  2  2  2                 2     1     3   |             

                                            __________________________________________________________________________|             
   Mesentery                               |                      +           +  +           +                    +   |             
      Fat, Hemorrhage                      |                                                                      2   |             
      Fat, Necrosis                        |                      3           3  2           2                    2   |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1        2              1                 1  1  2     1                 1|             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                                                               |             
      Basophilic Focus                     |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                  2                                       |             
      Ulcer                                |                               3                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   1                                                      |             
      Necrosis                             |                               2                                      1   |             
      Ulcer                                |                                  3                                       |             

                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             
      Epithelium, Hyperplasia              |                               2                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     1  2     1  3     2        2  1     1  2  1     1     2     1     1|             
      Atrium, Thrombosis                   |                                  3                                       |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 7| 2| 7| 0| 3| 3| 3| 3| 3| 7| 1| 7| 3| 5| 3|             
                                           | 4| 4| 5| 4| 6| 4| 5| 4| 5| 5| 9| 7| 6| 2| 6| 5| 6| 5| 5| 7| 3| 1| 5| 7| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      3   |             
      Degeneration, Cystic                 |                      3                    4                 2            |             
      Hyperplasia                          |          2  2  2        2     2        2     2  2  3  2     2     2     2|             
      Hypertrophy                          |    1  3     2        2           2                    2                  |             
      Necrosis                             |                                  2  3                    4               |             
      Thrombosis                           |                                                                2         |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2        2                 3                       4        2   |             
      Necrosis                             |                                                          4               |             
      Thrombosis                           |                                     2                                    |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2                                                                     |             
      Pars Distalis, Hyperplasia           |    2     3  3  2  4           2  4           3     4              3  2   |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     2  2  2  2  1  4  2  2  2  2        3  2  2  2     2  3  3  2  3  1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         | 2                                                                        |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             4        3                                               1   |             
      Inflammation, Granulomatous          |                3                                                         |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          3                                                               |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Myelofibrosis                        |                                        3                                 |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                  +                                       |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  M  +  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      2                                                   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 7| 2| 7| 0| 3| 3| 3| 3| 3| 7| 1| 7| 3| 5| 3|             
                                           | 4| 4| 5| 4| 6| 4| 5| 4| 5| 5| 9| 7| 6| 2| 6| 5| 6| 5| 5| 7| 3| 1| 5| 7| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                          4               |             
      Necrosis                             |                                     2                                    |             

                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             
      Inflammation, Chronic Active         |                         3                 4                              |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Epidermis, Hyperplasia               |                               2                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |       2  4     3                    1                                    |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |       2                                                                  |             
      Thrombosis                           |                                                             2            |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 | 3                                                                        |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1                          1     1           1        1                 1|             
      Alveolar Epithelium, Hyperplasia     |                                           1  4                 2         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1        1        1  1                 1  1        1  1        2         |             
      Bronchiole, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |                               3  4                                   4   |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |    1     1  1     1                                1        1  1         |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                   1                          1                 1         |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                              4        4                  |             
      Cornea, Infiltration Cellular,       |                                                                          |             
          Polymorphonuclear                |                                              1                           |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 7| 2| 7| 0| 3| 3| 3| 3| 3| 7| 1| 7| 3| 5| 3|             
                                           | 4| 4| 5| 4| 6| 4| 5| 4| 5| 5| 9| 7| 6| 2| 6| 5| 6| 5| 5| 7| 3| 1| 5| 7| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retina, Atrophy                      |                                              4        4                  |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 1  1  2  2  2  2  2  2  1  2  1  1  1     4  1  1  1  2  1  3  1  2     2|             
      Renal Tubule, Necrosis               |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6|  |            |
                             DAY ON TEST   | 3| 1| 3| 7| 7| 3| 0| 9| 0| 3| 2| 7| 3| 3| 8| 3| 0| 3| 3| 5| 3| 3| 3| 2|  |            |
                                           | 5| 9| 4| 2| 1| 5| 9| 0| 7| 5| 5| 1| 5| 5| 4| 5| 4| 5| 4| 7| 5| 6| 5| 5|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                   3                                                      |      2  3.0|
      Basophilic Focus                     | X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X   |     46     |
      Clear Cell Focus                     | X                          X                          X     X     X      |      7     |
      Eosinophilic Focus                   |       X                                                                  |      1     |
      Fatty Change                         |    1     2              2        3                       3               |     10  2.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      4     |
      Inflammation, Chronic                |                                                                   2      |      2  2.0|
      Mixed Cell Focus                     |       X  X           X  X                                            X   |      6     |
      Necrosis                             |                                                                          |      1  2.0|
      Regeneration                         |                         2                                                |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               |                         1     2                                          |      5  1.6|
      Centrilobular, Necrosis              |          1  3           1                                1               |     11  1.7|

                                            __________________________________________________________________________|____________|
   Mesentery                               |       +           +        +  +     +                    +  +     +      |  13        |
      Fat, Hemorrhage                      |                                                                          |      1  2.0|
      Fat, Necrosis                        |       3           2        2  3     2                    2  2     2      |     13  2.3|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              | 1  2        1  1  2     2           1  2     2                    2      |     18  1.4|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |                                                                          |      1  2.0|
      Basophilic Focus                     |                                              X                           |      1     |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Ulcer                                |    4                          2                                          |      3  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Mineralization                       |                                                                   1      |      2  1.0|
      Necrosis                             |                                                          1               |      3  1.3|
      Ulcer                                |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6|  |            |
                             DAY ON TEST   | 3| 1| 3| 7| 7| 3| 0| 9| 0| 3| 2| 7| 3| 3| 8| 3| 0| 3| 3| 5| 3| 3| 3| 2|  |            |
                                           | 5| 9| 4| 2| 1| 5| 9| 0| 7| 5| 5| 1| 5| 5| 4| 5| 4| 5| 4| 7| 5| 6| 5| 5|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cardiomyopathy                       | 1  1  2     2  1     1     1  2        1     3     2  1  2  2  1  1  2   |     32  1.5|
      Atrium, Thrombosis                   |             3                                                            |      2  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |                         2                                                |      2  2.5|
      Degeneration, Cystic                 |                                     3                                    |      4  3.0|
      Hyperplasia                          |                                     2  2  2  1     2  2  2  2  2     2   |     23  2.0|
      Hypertrophy                          |                                                                   2      |      7  2.0|
      Necrosis                             |             1                                                            |      4  2.5|
      Thrombosis                           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hyperplasia                          |             2              3                          4  2               |     10  2.6|
      Necrosis                             |                         2                                                |      2  3.0|
      Thrombosis                           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M   |  42        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                                             3            |      2  2.5|
      Pars Distalis, Hyperplasia           |          3              3  3  2     3  2  2  3  2        2  3  4  4      |     24  2.8|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +   |  47        |
      C-Cell, Hyperplasia                  | 2  1  2  1  2  2  1     2  3     2  2     3  1     1     2  2  1  1      |     39  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |                                                             2            |      1  2.0|
      Inflammation, Chronic Active         |                                                    2                     |      2  2.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cyst                                 |          2                             2     3              3            |      7  2.6|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cyst                                 |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6|  |            |
                             DAY ON TEST   | 3| 1| 3| 7| 7| 3| 0| 9| 0| 3| 2| 7| 3| 3| 8| 3| 0| 3| 3| 5| 3| 3| 3| 2|  |            |
                                           | 5| 9| 4| 2| 1| 5| 9| 0| 7| 5| 5| 1| 5| 5| 4| 5| 4| 5| 4| 7| 5| 6| 5| 5|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia, Reticulum Cell          | 2                                                                        |      1  2.0|
      Myelofibrosis                        |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                               +                                          |   2        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +   |  42        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  M  +  +  +  +  M   |  40        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Fibrosis                             |                         2     3                                          |      3  2.3|
      Hematopoietic Cell Proliferation     |                            2                                             |      2  3.0|
      Necrosis                             |                               3                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +   |  46        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Galactocele                          | 2                                                                        |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.5|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Chronic Active         |          2                                                               |      1  2.0|
      Epidermis, Hyperplasia               |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Osteopetrosis                        |             1                 3  2        3           2  3               |     10  2.4|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Degeneration                         |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Metaplasia, Squamous                 |                                                       2                  |      2  2.5|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Chronic Active         | 1     1        1     1              1           1  1  1  1        1      |     16  1.0|
      Alveolar Epithelium, Hyperplasia     |                            1                                             |      4  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    1  1  1     1        2              1     1  2        1     1         |     19  1.2|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 5| 7| 5| 6| 7| 5| 6| 7| 7| 7| 6| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 6|  |            |
                             DAY ON TEST   | 3| 1| 3| 7| 7| 3| 0| 9| 0| 3| 2| 7| 3| 3| 8| 3| 0| 3| 3| 5| 3| 3| 3| 2|  |            |
                                           | 5| 9| 4| 2| 1| 5| 9| 0| 7| 5| 5| 1| 5| 5| 4| 5| 4| 5| 4| 7| 5| 6| 5| 5|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|  |      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Bronchiole, Hyperplasia              |                                                       1                  |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Suppurative            |                                              1     1                     |      2  1.0|
      Thrombosis                           |          1  4           3                                3               |      7  3.1|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |          1     2  1           1     1              1                     |     13  1.1|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |                      1        1           1              1        1      |      8  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +   |  48        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Cataract                             | 2           3                                      4                     |      5  3.4|
      Cornea, Infiltration Cellular,       |                                                                          |            |
          Polymorphonuclear                |                                                          1               |      2  1.0|
      Retina, Atrophy                      | 2           4                                      4                     |      5  3.6|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                           +              +               |   2        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Nephropathy                          | 2  1  1  1        1  2  1  1     1  2  2     1     2  3     2  1  1  1   |     41  1.6|
      Renal Tubule, Necrosis               |                2                                                         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I   |  48        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 6| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 3| 7| 3| 3| 3| 3| 0| 6| 9| 7| 6| 4| 8| 4| 2| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 6| 1| 4| 7| 5| 4| 4| 4| 9| 5| 9| 7| 3| 0| 7| 7| 6| 5| 3| 5| 5| 5| 5| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2           2         |             
      Basophilic Focus                     | X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     | X     X     X        X  X                          X     X  X  X  X  X   |             
      Fatty Change                         |          3     2                             2                           |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Mixed Cell Focus                     |                                              X     X                     |             
      Necrosis                             |                                                                          |             
      Regeneration                         |                                              3                           |             
      Vacuolization Cytoplasmic, Focal     |                                           2                              |             
      Bile Duct, Hyperplasia               |                3                                                         |             
      Centrilobular, Necrosis              |          1     1                    3           2                        |             

                                            __________________________________________________________________________|             
   Mesentery                               |       +           +                       +              +        +     +|             
      Fat, Inflammation                    |                                                                          |             
      Fat, Necrosis                        |       2           2                       2              3        3     2|             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       1              1        1                          1               |             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Duct, Cyst                           |                                     4                                    |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       | 1                                                           1            |             
      Necrosis                             |                                     4                                    |             

                                            __________________________________________________________________________|             
   Tongue                                  |                               +                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1              2  1     1  1  1  1  1  2        1     1     2  1  2|             
      Atrium, Thrombosis                   |          3                          4                                    |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |             3                                                        2   |             
      Hyperplasia                          | 2           2                          1  1              2  2     2  2   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 6| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 3| 7| 3| 3| 3| 3| 0| 6| 9| 7| 6| 4| 8| 4| 2| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 6| 1| 4| 7| 5| 4| 4| 4| 9| 5| 9| 7| 3| 0| 7| 7| 6| 5| 3| 5| 5| 5| 5| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          | 2                                                     4                  |             
      Necrosis                             |          2                       2                                       |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                     3                                    |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     4                 3                  |             
      Pars Distalis, Hyperplasia           |       2  4  3        3  4     4              3                    4      |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       2  1  2  3  1  3  1  2  2  1  2  1  4     1  2  1  1  1  1  4  1   |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                                    |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          2  3                                      1           3         |             
      Inflammation, Granulomatous          |                                                                          |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                               +                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  M  +  +  +  M  +  M  +  +  M  +  +  M  +  +  M  M  +  +  +  +  M  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +  M  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | M  +  +  +  +  +  M  +  M  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            2        4                                    |             
      Hematopoietic Cell Proliferation     |                                                 3                        |             
      Hemorrhage                           |                                                                         2|             
      Necrosis                             |    3                                                                     |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemorrhage      |                         3                                                |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 6| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 3| 7| 3| 3| 3| 3| 0| 6| 9| 7| 6| 4| 8| 4| 2| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 6| 1| 4| 7| 5| 4| 4| 4| 9| 5| 9| 7| 3| 0| 7| 7| 6| 5| 3| 5| 5| 5| 5| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                      2                                                   |             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                      +                                                   |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1     1                 1           1     1        1  1  1  1            |             
      Alveolar Epithelium, Hyperplasia     |                      4  1           1           1  1                 1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                               2  1     1                    1            |             
      Bronchiole, Hyperplasia              |                                                                1         |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
      Thrombosis                           |          2                          4                                    |             
      Glands, Hyperplasia                  | 1  1  2  2  2  2  3  2  2  2  2  2  2  1  2  2  2  2     2  2  2  2  2  2|             
      Glands, Metaplasia, Squamous         |                                                                   2      |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     | 1           1  1  1  1                             1  1        1  1     1|             
      Olfactory Epithelium, Atrophy        | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  1  3  2  1  1  2  2  2|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 3  1  3  2  3  2  2  2  2  1  1     1  1  1  2  3  1  2  1  2  2  2  2  2|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Atypical                        | 2  1  2  2  2  2  2  1  2  3  2  2  2  2  2  2  2  2     2  2  2  2  2  2|             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic                         | 2  1  1  2  2  2  2  2  2  2     2  2  2  2  2  2  1  2  2  2  2  2  2  2|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1  1  1  1  1  1  2     2  1  2     2     1  2  1        1  2  2  1  1  1|             
      Respiratory Epithelium, Hyperplasia  | 1     1        1     1        1     2     1     3  4        1     1     1|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    2  1  2     1        1  2  2     1                 1                  |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                         4                                   4            |             
      Retina, Atrophy                      |                         4                                   4            |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                      +   |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 7| 6| 7| 7| 7| 7| 6| 6| 6| 5| 6| 4| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 8| 3| 7| 3| 3| 3| 3| 0| 6| 9| 7| 6| 4| 8| 4| 2| 3| 2| 3| 3| 3| 3| 3| 3|             
                                           | 6| 1| 4| 7| 5| 4| 4| 4| 9| 5| 9| 7| 3| 0| 7| 7| 6| 5| 3| 5| 5| 5| 5| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    10 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 2  1  1     2  1  1  2  1        1        1  1  1  1     2  1  2     2  2|             
      Renal Tubule, Necrosis               |                                     2                                    |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 6| 5| 7| 6| 7| 4| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 5| 6| 6| 7|  |            |
                             DAY ON TEST   | 7| 8| 3| 2| 0| 3| 0| 1| 7| 3| 3| 7| 2| 3| 7| 1| 3| 3| 2| 3| 0| 7| 7| 3|  |            |
                                           | 7| 1| 5| 5| 9| 5| 2| 3| 1| 5| 4| 4| 2| 6| 9| 8| 5| 6| 1| 5| 3| 9| 7| 6|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|  |      A     |
    10 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                                 3     2                  |      4  2.3|
      Basophilic Focus                     |    X  X  X  X  X     X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X   |     44     |
      Clear Cell Focus                     |       X                                X        X  X                 X   |     16     |
      Fatty Change                         |                                                                          |      3  2.3|
      Hepatodiaphragmatic Nodule           |                                                             X            |      1     |
      Mixed Cell Focus                     |                X                          X              X     X         |      6     |
      Necrosis                             |                                        2                                 |      1  2.0|
      Regeneration                         |                         2                                                |      2  2.5|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |          2           1                                1           2      |      5  1.8|
      Centrilobular, Necrosis              |          2        3  1  1                             2     1     2      |     11  1.7|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                      +               |   8        |
      Fat, Inflammation                    |                                                          2               |      1  2.0|
      Fat, Necrosis                        |                   3                                                      |      7  2.4|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              | 2           1           1     1                                   2      |      9  1.2|
      Basophilic Focus                     |                                                 X                        |      1     |
      Hyperplasia                          |                2                                                         |      1  2.0|
      Duct, Cyst                           |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Ulcer                                |                                                       3           3      |      2  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Mineralization                       |                                                                          |      2  1.0|
      Necrosis                             |                                                                   1      |      2  2.5|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cardiomyopathy                       | 2  2  1     1  1           1  2  1  1  1     1  2  1     1     1     2   |     31  1.3|
      Atrium, Thrombosis                   |                                                                          |      2  3.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 6| 5| 7| 6| 7| 4| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 5| 6| 6| 7|  |            |
                             DAY ON TEST   | 7| 8| 3| 2| 0| 3| 0| 1| 7| 3| 3| 7| 2| 3| 7| 1| 3| 3| 2| 3| 0| 7| 7| 3|  |            |
                                           | 7| 1| 5| 5| 9| 5| 2| 3| 1| 5| 4| 4| 2| 6| 9| 8| 5| 6| 1| 5| 3| 9| 7| 6|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|  |      A     |
    10 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Degeneration, Cystic                 |    2                                                                 2   |      4  2.3|
      Hyperplasia                          |       2                                         2        1  2            |     12  1.8|
      Hypertrophy                          |                                     2                    2               |      4  2.5|
      Necrosis                             |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic            |                      3                    2                              |      2  2.5|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          | 2        1                                            2                  |      3  1.7|
      Necrosis                             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  M   |  40        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                                                          |      2  3.5|
      Pars Distalis, Hyperplasia           |       4              1                             4  3     2            |     13  3.2|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      C-Cell, Hyperplasia                  |       2  2  2        1  1  3     2  3  1  2     2     2  2  2  2     3   |     37  1.9|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Hyperplasia                          |                               3                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cyst                                 |                      3        3  4                 3                 2   |      9  2.7|
      Inflammation, Granulomatous          |                                                                3         |      1  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                      +                                +                  |   3        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  M  +  M  +  M  +  +  M  +  M  +  +  +  +  M  +  +  M  +  +  +  +   |  33        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  M  M  M  +  +  +  +  +  +  +  +  M  +  +  +   |  39        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +   |  39        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Fibrosis                             |                                                                   2      |      3  2.7|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 6| 5| 7| 6| 7| 4| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 5| 6| 6| 7|  |            |
                             DAY ON TEST   | 7| 8| 3| 2| 0| 3| 0| 1| 7| 3| 3| 7| 2| 3| 7| 1| 3| 3| 2| 3| 0| 7| 7| 3|  |            |
                                           | 7| 1| 5| 5| 9| 5| 2| 3| 1| 5| 4| 4| 2| 6| 9| 8| 5| 6| 1| 5| 3| 9| 7| 6|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|  |      A     |
    10 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     | 4                 3                                      2               |      4  3.0|
      Hemorrhage                           |    4                                                                     |      2  3.0|
      Necrosis                             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  45        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Galactocele                          |                               2                                      3   |      2  2.5|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Osteopetrosis                        |                            2     2                    2                  |      4  2.0|

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                       +                  |   2        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Chronic Active         |                      1     1     1              1  1           1         |     15  1.0|
      Alveolar Epithelium, Hyperplasia     |                      1        1           1     4              1         |     11  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                               1        1     1                           |      7  1.1|
      Bronchiole, Hyperplasia              |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Suppurative            | 2        1                                      2     3  2               |      5  2.0|
      Thrombosis                           |                                                       2           4      |      4  3.0|
      Glands, Hyperplasia                  | 2  1  2  2  1  2  1  2  2  2  2  2  1  2  2  2  2  2  2  2  2  2  2  2   |     48  1.9|
      Glands, Metaplasia, Squamous         |                      2                                                   |      2  2.0|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |    1           1              1        1        1        1               |     16  1.0|
      Olfactory Epithelium, Atrophy        | 2  2  2  2  2  2  2  2  1  2  1  2  2  2  3  2  1  2  2  1  2  2  2  2   |     49  1.9|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  2  3  2  1  2  2  1  1  2  2  2  1  2  1     3  3     1  1  1  2  1   |     46  1.8|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Atypical                        | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2   |     48  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 5| 7| 6| 5| 7| 6| 7| 4| 6| 7| 5| 6| 7| 6| 5| 7| 7| 7| 7| 5| 6| 6| 7|  |            |
                             DAY ON TEST   | 7| 8| 3| 2| 0| 3| 0| 1| 7| 3| 3| 7| 2| 3| 7| 1| 3| 3| 2| 3| 0| 7| 7| 3|  |            |
                                           | 7| 1| 5| 5| 9| 5| 2| 3| 1| 5| 4| 4| 2| 6| 9| 8| 5| 6| 1| 5| 3| 9| 7| 6|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|  |      A     |
    10 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic                         | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2     1  2  1  2  2   |     47  1.9|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 2  1     1     1     1     1  1                    1  1  1     1  1  1   |     33  1.2|
      Respiratory Epithelium, Hyperplasia  | 3              1                          1           2     2  1         |     18  1.6|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 1  2              2  1  2        2  2     2  1        2        2  2      |     21  1.6|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +   |  47        |
      Cataract                             |                                                                          |      2  4.0|
      Retina, Atrophy                      |                                                                          |      2  4.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cyst                                 |                                                          2               |      1  2.0|
      Nephropathy                          | 4     2        2  1  1     2  2  1  2  2  2  1  1  2  1  2  1  2  1  3   |     38  1.6|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 5| 5| 7| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 7| 8| 2| 3| 1| 8| 8| 3| 4| 9| 4| 3| 3| 3| 3|             
                                           | 4| 5| 5| 5| 4| 3| 5| 2| 4| 6| 1| 5| 4| 4| 5| 7| 7| 4| 0| 9| 0| 5| 6| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                          1         |             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |          X        X                    X                                 |             
      Eosinophilic Focus                   | X                 X                          X                 X  X      |             
      Fatty Change                         |                                     3                                    |             
      Hepatodiaphragmatic Nodule           |                X  X                    X                          X      |             
      Mixed Cell Focus                     |                X     X           X        X  X  X                        |             
      Necrosis                             |                                                                          |             
      Regeneration                         |                                              2                           |             
      Bile Duct, Hyperplasia               |          1                                   2           2               |             
      Centrilobular, Necrosis              |                               1              1           1               |             
      Hepatocyte, Atrophy                  |                                                                          |             

                                            __________________________________________________________________________|             
   Mesentery                               |                +        +                 +     +                        |             
      Fat, Necrosis                        |                2        2                 3     2                        |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1                                            2  1                       1|             
      Basophilic Focus                     |                                                                   X      |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                               3                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                3         |             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                             +            |             
      Malformation                         |                                                             X            |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1  2  1  2  1     1           1     1  1           3  1        1  1  1   |             
      Atrium, Thrombosis                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2                                      2                              |             
      Hyperplasia                          |    2  2     2  2                    2              2           2  2      |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 5| 5| 7| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 7| 8| 2| 3| 1| 8| 8| 3| 4| 9| 4| 3| 3| 3| 3|             
                                           | 4| 5| 5| 5| 4| 3| 5| 2| 4| 6| 1| 5| 4| 4| 5| 7| 7| 4| 0| 9| 0| 5| 6| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          | 2  1  2                                         1  1  2           1  2   |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1                       2                          1                     |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1                                                               |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  M  M  +  +  +  +  M  +  +  +  +  +  M  M  M  +  +  +|             
      Hyperplasia                          |                                                                          |             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Pars Distalis, Hyperplasia           |       3           3     3  4  2                    3  2        2     2  2|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1  1     1  2  2     2     1  1  1  1  2  2  2  2  1           1     1|             
      Follicular Cell, Hyperplasia         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3                       3                              |             
      Inflammation, Chronic Active         |                                                    3                     |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    2        3     2     4                       3                       1|             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |             2                                                            |             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  M  +  M  +  M  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                1                                                         |             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       1                                                                  |             
      Hematopoietic Cell Proliferation     |                                                       3                  |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 5| 5| 7| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 7| 8| 2| 3| 1| 8| 8| 3| 4| 9| 4| 3| 3| 3| 3|             
                                           | 4| 5| 5| 5| 4| 3| 5| 2| 4| 6| 1| 5| 4| 4| 5| 7| 7| 4| 0| 9| 0| 5| 6| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                              4                           |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |          2                             3     1                       2   |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         3|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |             3                                                            |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion, Chronic                  |                                                                          |             
      Inflammation, Chronic Active         |          1  1     1  1  1        1     2           1        1     1  1   |             
      Metaplasia, Osseous                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                         1  1           1     1     4           1     1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |    1        1                       1        1        1                  |             
      Bronchiole, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                           1              1  3            |             
      Thrombosis                           |                               4                                          |             
      Glands, Hyperplasia                  | 3  3  2  3  3  2  4  3  3  3  4  3  3  2  2  3  3  4  3  3  3  3  3  3  3|             
      Glands, Metaplasia, Squamous         | 2  3              2     2  4  2     2     1     3        3     2        1|             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     | 1  1  1  1  1     1     1  2     1     2  1        1     1  1  2  1  1   |             
      Olfactory Epithelium, Atrophy        | 3  3  2  3  2  2  2  3  2  3  3  3  2  3  2  3  3  3  3  3  3  3  3  3  2|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 3  3  2  2  3  2  2  1  3  2  2  2  2  2  2  1  2  3  1  2  2  3  2  3  3|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Atypical                        | 2  3  3  2  2  2  2  3  2  2  2  2  2  3  2  2  2  3  3  2  2  2  2  3  2|             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic                         | 2  2  2  3  3  2  3  3  3  3  3  3  2  2  2  2  3  3     3  2  3  3  3  3|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |       1     2  1  2     2        1  1  1  2     1  1  2  1  2        1  2|             
      Respiratory Epithelium, Hyperplasia  | 2  1           2              2  1  2     2  2     2     1              2|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |                      1        2  1  1     1  2  1     1  2               |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 6| 6| 6| 7| 7| 5| 5| 7| 4| 6| 4| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 5| 3| 1| 3| 3| 7| 8| 2| 3| 1| 8| 8| 3| 4| 9| 4| 3| 3| 3| 3|             
                                           | 4| 5| 5| 5| 4| 3| 5| 2| 4| 6| 1| 5| 4| 4| 5| 7| 7| 4| 0| 9| 0| 5| 6| 5| 5|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             | 1     1                                      4                           |             
      Retina, Atrophy                      | 2                                            4                           |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Nephropathy                          | 2  1  2     2  2  1     1  1     2  2  2  2     1  1     1     2  2  1  1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 5| 4| 6| 7| 7| 6| 7|  |            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 3| 8| 8| 8| 5| 3| 3| 6| 3|  |            |
                                           | 5| 5| 5| 6| 4| 4| 5| 4| 5| 1| 5| 4| 7| 8| 0| 5| 6| 1| 0| 3| 5| 4| 0| 6|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                                                          |      2  1.5|
      Basophilic Focus                     | X     X  X  X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X     X   |     46     |
      Clear Cell Focus                     |          X     X  X              X                          X            |      8     |
      Eosinophilic Focus                   |                      X                                                   |      6     |
      Fatty Change                         |                                     3                                    |      2  3.0|
      Hepatodiaphragmatic Nodule           |                X                                   X                     |      6     |
      Mixed Cell Focus                     |                               X                                          |      7     |
      Necrosis                             |          2                                                               |      1  2.0|
      Regeneration                         |                                                          2               |      2  2.0|
      Bile Duct, Hyperplasia               |                         1                    1                           |      5  1.4|
      Centrilobular, Necrosis              |                                     2           2        1        1      |      7  1.3|
      Hepatocyte, Atrophy                  |                         2                                                |      1  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                    +                    +                           |   7        |
      Fat, Necrosis                        |                         2                    2                           |      6  2.2|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |    2                 1  3        1           1  1        1               |     11  1.4|
      Basophilic Focus                     |                                                                          |      1     |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Ulcer                                |    4                                                                     |      2  3.5|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Necrosis                             |                                     3                                    |      1  3.0|
      Ulcer                                |    2                                                                     |      1  2.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Malformation                         |                                                                          |      1     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cardiomyopathy                       | 1     2  2  1  1  2        1  2  1  1  1  1     3  1        1  1     1   |     31  1.3|
      Atrium, Thrombosis                   |                                                 4                        |      1  4.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 5| 4| 6| 7| 7| 6| 7|  |            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 3| 8| 8| 8| 5| 3| 3| 6| 3|  |            |
                                           | 5| 5| 5| 6| 4| 4| 5| 4| 5| 1| 5| 4| 7| 8| 0| 5| 6| 1| 0| 3| 5| 4| 0| 6|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Degeneration, Cystic                 |                                                 2                        |      3  2.0|
      Hyperplasia                          | 2        2           2     2     2              2        2  2  2     2   |     18  2.0|
      Hypertrophy                          |             2  4              1                             2            |     12  1.8|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |       1        1                          2     2        2        2      |      9  1.6|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +   |  41        |
      Hyperplasia                          |                         3                                                |      1  3.0|

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                               3     4                                    |      3  3.0|
      Pars Distalis, Hyperplasia           |          2                    2  3                    2     3  2  3  2   |     18  2.5|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      C-Cell, Hyperplasia                  |    2  1  2  2  2  2  1  2  2  1  1        3  3     1  1  1  1  2  2      |     37  1.5|
      Follicular Cell, Hyperplasia         |                2                                                         |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cyst                                 |             3     2  2  2  3                                             |     11  2.5|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                 +                        |   1        |
      Inflammation, Suppurative            |                                                 3                        |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia, Reticulum Cell          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                          +               |   2        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | M  +  +  +  M  M  +  +  +  +  +  M  +  +  M  +  M  M  M  +  M  +  +  +   |  34        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 5| 4| 6| 7| 7| 6| 7|  |            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 3| 8| 8| 8| 5| 3| 3| 6| 3|  |            |
                                           | 5| 5| 5| 6| 4| 4| 5| 4| 5| 1| 5| 4| 7| 8| 0| 5| 6| 1| 0| 3| 5| 4| 0| 6|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  +  +  +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  M  +   |  41        |
      Congestion                           |                                                 3                        |      1  3.0|
      Hemorrhage                           |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Fibrosis                             |             2                                                     2      |      3  1.7|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Necrosis                             |    2                                                                     |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Cyst                                 |                                  2                                       |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Galactocele                          |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Osteopetrosis                        |                                                             3  3  2      |      7  2.3|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Metaplasia, Squamous                 |    2     2                                      3                        |      4  2.5|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Congestion, Chronic                  |                                                 3                        |      1  3.0|
      Inflammation, Chronic Active         | 1                 1     1  1     1  1        1                       1   |     19  1.1|
      Metaplasia, Osseous                  |                                                 2                        |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                4                                   2           1     1   |     11  1.6|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       1     1     1           1                    1        1            |     11  1.0|
      Bronchiole, Hyperplasia              |                               1                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Suppurative            |                                                    1           2         |      5  1.6|
      Thrombosis                           |    1                                            1                        |      3  2.0|
      Glands, Hyperplasia                  | 3  3  4  3  4  3  3  4  4  3  4  4  3  3  3  3  3  2     3  3  3  3  3   |     48  3.1|
      Glands, Metaplasia, Squamous         |                      3  3  2  3  4                       3  2     2      |     21  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 5| 5| 4| 6| 7| 7| 6| 7|  |            |
                             DAY ON TEST   | 3| 1| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 0| 8| 3| 3| 8| 8| 8| 5| 3| 3| 6| 3|  |            |
                                           | 5| 5| 5| 6| 4| 4| 5| 4| 5| 1| 5| 4| 7| 8| 0| 5| 6| 1| 0| 3| 5| 4| 0| 6|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|  |      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |       1  2  1        1  1     1  2                    2     1  1  1  1   |     29  1.2|
      Olfactory Epithelium, Atrophy        | 2  3  2  3  3  3  3  3  3  2  2  2  3  3  3  2  4  3  3  3  2  3  3  2   |     49  2.7|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 3  2  3  3  3  3  2  2  2  2  2  2  1  2  2  1  2  1  2  2  1  2  2  2   |     49  2.1|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Atypical                        | 2  2  2  2  4  3  3  3  3  2  3  2  3  3  2  2  3  2     2  3  3  3  2   |     48  2.4|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic                         | 2  2  3  2  3  3  3  3  3  2  3  3  2  2  2  3  2  2     3  3  3  3  3   |     47  2.6|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 2     1  2  2  2  1  1  1     2  1  2  1  2        1     1     1  1  1   |     34  1.4|
      Respiratory Epithelium, Hyperplasia  |    2  2     1  3              2  4        2  2        1  1        2      |     22  1.9|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |    2                       2        2  1  2        1     1        2      |     17  1.5|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +     +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Cataract                             |                4              4                          3               |      6  2.8|
      Retina, Atrophy                      |                4              4                                          |      4  3.5|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Infarct                              |                                                          3               |      1  3.0|
      Nephropathy                          | 1     1  1  1  1  2     1  2  1  1  1  1           1           1     1   |     34  1.4|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 4| 7| 7| 6| 7| 1| 4| 7| 7|             
                             DAY ON TEST   | 4| 7| 3| 2| 3| 8| 3| 3| 2| 2| 3| 1| 3| 8| 3| 6| 2| 3| 3| 7| 3| 1| 7| 3| 3|             
                                           | 7| 9| 5| 4| 6| 5| 5| 5| 2| 5| 5| 7| 5| 4| 6| 7| 9| 5| 5| 7| 5| 1| 8| 5| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    60 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         2|             
      Basophilic Focus                     | X  X  X  X  X  X  X  X  X  X  X  X  X  X  X        X  X  X  X        X  X|             
      Clear Cell Focus                     |                      X              X                       X        X   |             
      Cyst                                 |                                           2                              |             
      Eosinophilic Focus                   |                         X                                                |             
      Fatty Change                         |                                  2           3                           |             
      Hepatodiaphragmatic Nodule           |             X           X        X                                       |             
      Mixed Cell Focus                     |    X           X                                         X               |             
      Regeneration                         |    3                                                                     |             
      Bile Duct, Hyperplasia               |    2                    2  2                                      2      |             
      Centrilobular, Necrosis              |    2     1     2        1     1                                   1      |             

                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +              +      |             
      Fat, Necrosis                        |                                                    2              2      |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2           1              1        1              1        1      |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                                                               |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                              2                           |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                   1                                                      |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
      Malformation                         |                                                                X         |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 1     1     2     1  1  2     1  1     2  1        1  1  2  1        2  1|             
      Atrium, Thrombosis                   |    2                                                                     |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          | 2     1                 2     2     2     2  1     2           2  2  2  2|             
      Hypertrophy                          |    2              1                       2                          2   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 4| 7| 7| 6| 7| 1| 4| 7| 7|             
                             DAY ON TEST   | 4| 7| 3| 2| 3| 8| 3| 3| 2| 2| 3| 1| 3| 8| 3| 6| 2| 3| 3| 7| 3| 1| 7| 3| 3|             
                                           | 7| 9| 5| 4| 6| 5| 5| 5| 2| 5| 5| 7| 5| 4| 6| 7| 9| 5| 5| 7| 5| 1| 8| 5| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    60 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |          2                                                               |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        2                                 |             
      Cyst                                 |             2                                                            |             
      Pars Distalis, Hyperplasia           | 1                 3     3  3              3  1                    4  2   |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 3     2  3  1  2  2     2  2     2  3  2  3  3     1  1  1  1     2  2  1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                      3   |             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | 4                                                        2     2  2      |             
      Inflammation, Granulomatous          |                      4                                                   |             

                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node                              |          +              +     +                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  M  +  M  +  +  M  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  M  M|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  +  M  +  M  M  +  +  +  +  M  M  M  M  M  M  M  M  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |          2                       2                                       |             
      Hematopoietic Cell Proliferation     | 2                                      2                       2         |             
      Hemorrhage                           |             3                                                            |             
      Metaplasia, Osseous                  |          2                                                               |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M  +  M|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Galactocele                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 4| 7| 7| 6| 7| 1| 4| 7| 7|             
                             DAY ON TEST   | 4| 7| 3| 2| 3| 8| 3| 3| 2| 2| 3| 1| 3| 8| 3| 6| 2| 3| 3| 7| 3| 1| 7| 3| 3|             
                                           | 7| 9| 5| 4| 6| 5| 5| 5| 2| 5| 5| 7| 5| 4| 6| 7| 9| 5| 5| 7| 5| 1| 8| 5| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    60 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Atypical                |                                                                          |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                         3                          3                     |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Metaplasia, Squamous                 |                                  2                                       |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 1     1  1  1     2     1           1  1  1  1     1                     |             
      Alveolar Epithelium, Hyperplasia     |       1     2        1                    3              2           1   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                1        1  1  1     1                 1     1     2  1   |             
      Bronchiole, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                         2                 1  1                 2         |             
      Thrombosis                           |    4                                            3                        |             
      Glands, Hyperplasia                  |    3  3     4  3  3  4  3  4  3  3  4  3  4  3     3  4  3  4  2  3  4  3|             
      Glands, Metaplasia, Squamous         |    3  2     2  2        2  2        4                 3     3        4   |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     |             1        1        1  1  1     1        1  1  1  1           1|             
      Olfactory Epithelium, Atrophy        | 3  3  3  4  3  4  3  2  4  3  3  3  3  2  3  3     3  3  4  2  2  3  4  3|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 1  1  2  2  2  3  3  3  2  2  2  1  3  2  3  3  1  3  2  1  2     1  3  3|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Atypical                        |    4  3  2  3  3  4  3  2  3  3  2  3  3  3  2     2  3  1  3  2  3  3  3|             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic                         |    4  3  2  4  4  4  3  3  4  4  3  4  4  4  3  2  3  4  4  4  2  3  4  4|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1     1        1  1  1  1        1     2     1  2  1        1           1|             
      Respiratory Epithelium, Hyperplasia  |    2     2     3        3  1  2  1     2     4                    1  2   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |          2     3        2  1     1              2  2                     |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 5| 5| 7| 6| 7| 6| 7| 7| 7| 6| 7| 6| 7| 6| 7| 6| 4| 7| 7| 6| 7| 1| 4| 7| 7|             
                             DAY ON TEST   | 4| 7| 3| 2| 3| 8| 3| 3| 2| 2| 3| 1| 3| 8| 3| 6| 2| 3| 3| 7| 3| 1| 7| 3| 3|             
                                           | 7| 9| 5| 4| 6| 5| 5| 5| 2| 5| 5| 7| 5| 4| 6| 7| 9| 5| 5| 7| 5| 1| 8| 5| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    60 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|             
      Cataract                             |                   3                             2                        |             
      Retina, Atrophy                      |                   4                                                      |             

                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Inflammation, Chronic                |                                                                   3      |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |          3                                                               |             
      Nephropathy                          | 1     2     1     1     1     2  1  1  1  2        2  2  2  1        2  1|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 5| 6| 7| 6| 4| 6| 4| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|  |            |
                             DAY ON TEST   | 3| 8| 2| 5| 0| 0| 3| 5| 4| 2| 8| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|  |            |
                                           | 5| 0| 0| 5| 3| 1| 6| 6| 5| 5| 2| 3| 5| 6| 5| 2| 6| 4| 4| 6| 4| 5| 5| 5|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |      A     |
    60 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Inflammation, Acute                  |                      2                                                   |      1  2.0|

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     | X  X  X  X  X  X  X  X     X  X  X  X  X  X  X  X  X  X  X  X  X  X  X   |     44     |
      Clear Cell Focus                     |                   X                                         X            |      6     |
      Cyst                                 |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                     X                                    |      2     |
      Fatty Change                         |                         2              3                                 |      4  2.5|
      Hepatodiaphragmatic Nodule           |       X     X                                                            |      5     |
      Mixed Cell Focus                     |          X        X                          X                           |      6     |
      Regeneration                         |                      3                                                   |      2  3.0|
      Bile Duct, Hyperplasia               |                      2              2                                    |      6  2.0|
      Centrilobular, Necrosis              |                      1           2     1                                 |      9  1.3|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                            +                    +     +                  |   5        |
      Fat, Necrosis                        |                            2                    2     3                  |      5  2.2|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |       2                          2                       2           1   |     10  1.4|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |                                                       1                  |      2  1.5|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Mineralization                       |                                                    1                     |      2  1.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  | +                                                                        |   1        |

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Malformation                         |                                                                          |      1     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cardiomyopathy                       | 3  1     1  1  1  1        1     2  1  1     2  2  1  1  1     1  1  2   |     34  1.3|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 5| 6| 7| 6| 4| 6| 4| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|  |            |
                             DAY ON TEST   | 3| 8| 2| 5| 0| 0| 3| 5| 4| 2| 8| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|  |            |
                                           | 5| 0| 0| 5| 3| 1| 6| 6| 5| 5| 2| 3| 5| 6| 5| 2| 6| 4| 4| 6| 4| 5| 5| 5|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |      A     |
    60 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Degeneration, Cystic                 | 2  2                                                        2            |      3  2.0|
      Hyperplasia                          | 1     2           2  2        2     2              2  2  2  2  2     2   |     24  1.9|
      Hypertrophy                          |                         2                 1                              |      6  1.7|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                          2               |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |                                  2     2              2  2               |      5  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Angiectasis                          |                                  2                                       |      2  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |    4     4           1              3              3     2  2            |     15  2.6|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      C-Cell, Hyperplasia                  | 2  1     2  1  1  2     1  1  1  1  1  1  2  1  2  1  1  1  1  2  1  2   |     42  1.6|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hyperplasia                          |                   3                                2                     |      3  2.7|
      Inflammation, Chronic Active         |                      3                                                   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cyst                                 |    2                                      3                 2  2         |      8  2.4|
      Inflammation, Granulomatous          |                                                             4            |      2  4.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |                                              2                           |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |   3        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +   |  36        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +   |  31        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 5| 6| 7| 6| 4| 6| 4| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|  |            |
                             DAY ON TEST   | 3| 8| 2| 5| 0| 0| 3| 5| 4| 2| 8| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|  |            |
                                           | 5| 0| 0| 5| 3| 1| 6| 6| 5| 5| 2| 3| 5| 6| 5| 2| 6| 4| 4| 6| 4| 5| 5| 5|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |      A     |
    60 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Fibrosis                             |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                3         |      4  2.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Necrosis                             |                      3                                                   |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +   |  41        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Galactocele                          | 3                                                                        |      1  3.0|
      Hyperplasia, Atypical                |                                              3                           |      1  3.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperkeratosis                       |                                     4                                    |      1  4.0|
      Inflammation, Acute                  |                                     4  4                                 |      2  4.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Osteopetrosis                        |                               3     2        2                           |      5  2.6|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Chronic Active         | 1  1  1        1                    1     1  1  1  1     1        1      |     22  1.0|
      Alveolar Epithelium, Hyperplasia     | 1                                                     3           1      |      9  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                   1        1  1        1        1                        |     14  1.1|
      Bronchiole, Hyperplasia              |                                                    1                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Suppurative            |                         2                                                |      5  1.6|
      Thrombosis                           |                      1                                                   |      3  2.7|
      Glands, Hyperplasia                  | 3     4     2  2  4  3     3  2  3  3     3  3  4  4  4  4  4  3  3  4   |     42  3.3|
      Glands, Metaplasia, Squamous         | 2                 3                 2     2     4  4     4  3  2  2      |     20  2.8|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |                   1                 1     1        1  1  1  1  1  1      |     20  1.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 5| 6| 7| 6| 4| 6| 4| 6| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|  |            |
                             DAY ON TEST   | 3| 8| 2| 5| 0| 0| 3| 5| 4| 2| 8| 4| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3|  |            |
                                           | 5| 0| 0| 5| 3| 1| 6| 6| 5| 5| 2| 3| 5| 6| 5| 2| 6| 4| 4| 6| 4| 5| 5| 5|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|  |      A     |
    60 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Atrophy        | 3  4  3     3  3  3  4  4  4  3  4  3  3  3  4  3  4  3  4  3  3  3  2   |     47  3.2|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 3  2  3     2  2  2  2     1  1  1  1     3  1  3  4  2  2  2  2  3  3   |     45  2.1|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Atypical                        | 3     3     2  3  4  3     3  3  4  3     4  3  3  2  3  2  3  3  3  4   |     43  2.9|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic                         | 4  3  4     3  4  4  3     3  3  3  3     3  3  4  3  4  3  4  3  4  4   |     45  3.4|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 2              1     2  1  2  1        2     1  1  1  1  1  1     1  1   |     28  1.2|
      Respiratory Epithelium, Hyperplasia  | 1                 1  2        1  1  1  1  1        1  1     4        1   |     23  1.7|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |    2  2  1  2  1     2        1  3                                       |     15  1.8|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Cataract                             |                                                                      4   |      3  3.0|
      Retina, Atrophy                      |                                                                      3   |      2  3.5|

                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Infarct                              |                                                                          |      1  3.0|
      Nephropathy                          | 2  1  1              1     1     1  1  1  1  1        3  1  2  1  2      |     31  1.4|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 5| 7| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 0| 0| 1| 3| 9| 3| 3| 5| 3| 3| 3| 3| 2| 3| 0| 9| 3| 1| 7| 7|             
                                           | 4| 3| 3| 9| 3| 2| 8| 6| 9| 5| 3| 3| 7| 3| 3| 4| 4| 6| 4| 3| 2| 3| 3| 8| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              1                           |             
      Basophilic Focus                     | X  X  X  X  X     X  X        X  X  X  X  X  X  X  X  X     X  X  X      |             
      Clear Cell Focus                     | X  X        X                 X  X     X        X     X                  |             
      Degeneration, Cystic                 |                                  2                                       |             
      Eosinophilic Focus                   |       X                                                                  |             
      Fatty Change                         |                                     1                             2      |             
      Hepatodiaphragmatic Nodule           |                                                             X            |             
      Mixed Cell Focus                     |                   X                                                      |             
      Regeneration                         |                                                                          |             
      Artery, Inflammation                 |                                                             3            |             
      Bile Duct, Hyperplasia               | 1  2  1     2  2        2  2     2     1  3  2  1  2  2  3  2        2  2|             
      Centrilobular, Necrosis              |          2     2        1                    1           2  4        2  3|             

                                            __________________________________________________________________________|             
   Mesentery                               | +  +           +     +        +     +  +                    +            |             
      Artery, Inflammation, Chronic Active |                               4     3                       3            |             
      Fat, Necrosis                        | 2  2           2     2              3                                    |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1  2     1     1           1        3        2     1           2     3|             
      Artery, Inflammation                 |                               3                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                         2|             
      Necrosis                             |                                                                         3|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Hyperplasia, Squamous                |                                  1                                       |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |          3     1                                         2           2  1|             
      Artery, Inflammation                 |                               3                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1     3     2  2  2  2  2  2  1  2  1  1  2  3  2  2  3  2  2  2   |             
      Necrosis                             |                                                                          |             
      Atrium, Thrombosis                   |                         3                                2               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 5| 7| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 0| 0| 1| 3| 9| 3| 3| 5| 3| 3| 3| 3| 2| 3| 0| 9| 3| 1| 7| 7|             
                                           | 4| 3| 3| 9| 3| 2| 8| 6| 9| 5| 3| 3| 7| 3| 3| 4| 4| 6| 4| 3| 2| 3| 3| 8| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |    2     2  2  2  2        2           2        2     2     1  2  2     2|             
      Hypertrophy                          |    2                          2     2                                2   |             
      Vacuolization Cytoplasmic            |                         2                                                |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2  2  2     2                 2        2     1  4  4     2        3     1|             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Pars Distalis, Hyperplasia           | 4  4     2        3           2                             2  4         |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2     1  1  1  1        3  3     1  1  2     1        1  2  2  1  1  2   |             
      Follicular Cell, Hyperplasia         |                               2        3                                 |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                         2|             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  4              1                                2  2        2         |             
      Inflammation, Chronic Active         |                                              3           3        4      |             
      Epithelium, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Interstitial Cell, Hyperplasia       |          2                                                              1|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                          +               |             
      Iliac, Hemorrhage                    |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | M  +  +  M  +  +  M  +  M  M  M  +  M  +  M  M  +  M  +  M  M  +  M  +  M|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  M  +  +  +  +  M  M  +  +  +  M  +  +  M  +  +  M  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 5| 7| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 0| 0| 1| 3| 9| 3| 3| 5| 3| 3| 3| 3| 2| 3| 0| 9| 3| 1| 7| 7|             
                                           | 4| 3| 3| 9| 3| 2| 8| 6| 9| 5| 3| 3| 7| 3| 3| 4| 4| 6| 4| 3| 2| 3| 3| 8| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  M  +  M  M  M  +  M  M  M  M  M  +  M  M  M  M  M  +  M  M  M  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                1           2                                             |             
      Hematopoietic Cell Proliferation     |                                                                3         |             
      Hemorrhage                           |                         3                    2                           |             
      Necrosis                             |          2                                                           4   |             
      Thrombosis                           |                2                                                         |             

                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  +  +  M  M  M  +  M  +  +  M  +  +  M  +  M  M  M  M  M  +|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                  3                                       |             
      Inflammation, Chronic Active         |                                                 2  3        3            |             
      Epithelium, Hyperplasia, Basal Cell  |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Artery, Inflammation                 |                               2                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                    X                     |             
      Hemorrhage                           |                                  1                                       |             
      Inflammation, Chronic Active         |                               1                                          |             
      Inflammation, Granulomatous          |                                                    4                     |             
      Metaplasia, Osseous                  |                         1                                                |             
      Thrombosis                           |                                                                      3   |             
      Alveolar Epithelium, Hyperplasia     | 1           3        4     1  2     1  1  1     1     2  1     2         |             
      Alveolar Epithelium, Metaplasia      | 2                                                                        |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       1                             1                          1         |             
      Bronchiole, Hyperplasia              | 1                                                                        |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Suppurative            |                   2        2  1                          3     2     3   |             
      Thrombosis                           |          4     1        4                                               4|             
      Glands, Hyperplasia                  |       1                                                                  |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 5| 7| 5| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 6| 3| 0| 0| 1| 3| 9| 3| 3| 5| 3| 3| 3| 3| 2| 3| 0| 9| 3| 1| 7| 7|             
                                           | 4| 3| 3| 9| 3| 2| 8| 6| 9| 5| 3| 3| 7| 3| 3| 4| 4| 6| 4| 3| 2| 3| 3| 8| 2|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Atrophy        |                                                                          |             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         |       1                                               2  1               |             
      Respiratory Epithelium, Hyperplasia  |       1                                                           1      |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Cataract                             |       2              4                    3                              |             
      Inflammation, Suppurative            |                                                                          |             
      Retina, Atrophy                      |                      4                    3                              |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                3                                            3           3|             
      Nephropathy                          | 3  2  2  1  3     1     1  3  1  1  1  2  2  2  3  2  2  2     1  3  2   |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          3                                                               |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 4| 7| 7| 6| 7|  |            |
                             DAY ON TEST   | 3| 6| 3| 3| 3| 1| 2| 3| 2| 3| 3| 3| 3| 6| 7| 1| 3| 6| 3| 6| 0| 3| 5| 3|  |            |
                                           | 3| 0| 3| 4| 4| 5| 4| 3| 1| 3| 4| 4| 4| 0| 7| 5| 3| 0| 4| 0| 9| 3| 8| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +   |  46        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +   |  45        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +   |  45        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |       X  X  X  X     X  X  X  X  X  X              X  X        X  X  X   |     34     |
      Clear Cell Focus                     |             X        X     X     X  X                          X         |     14     |
      Degeneration, Cystic                 |                               2                                      2   |      3  2.0|
      Eosinophilic Focus                   |                                                 X     X                  |      3     |
      Fatty Change                         |                                                                          |      2  1.5|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Mixed Cell Focus                     |                                                    X  X                  |      3     |
      Regeneration                         | 3                                                                        |      1  3.0|
      Artery, Inflammation                 |                                                                          |      1  3.0|
      Bile Duct, Hyperplasia               | 2        2  1     2  2     1  3  1  2  1  2  1  2  2        2  1  2      |     35  1.8|
      Centrilobular, Necrosis              | 2  4              1                       1                          3   |     13  2.2|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +        +  +        +  +                           |  13        |
      Artery, Inflammation, Chronic Active |                                                                          |      3  3.3|
      Fat, Necrosis                        |                      2        2  2        2  2                           |     10  2.1|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |       3        2  1     3        1  1  1  1        1                     |     19  1.6|
      Artery, Inflammation                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Diverticulum                         |       X                                                                  |      1     |
      Hyperplasia, Squamous                |                                        2                                 |      2  1.5|
      Ulcer                                |                                        3                                 |      1  3.0|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Necrosis                             |    3                                                                 1   |      7  1.9|
      Artery, Inflammation                 |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                        +                                 |   1        |
      Inflammation, Chronic Active         |                                        4                                 |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 4| 7| 7| 6| 7|  |            |
                             DAY ON TEST   | 3| 6| 3| 3| 3| 1| 2| 3| 2| 3| 3| 3| 3| 6| 7| 1| 3| 6| 3| 6| 0| 3| 5| 3|  |            |
                                           | 3| 0| 3| 4| 4| 5| 4| 3| 1| 3| 4| 4| 4| 0| 7| 5| 3| 0| 4| 0| 9| 3| 8| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cardiomyopathy                       | 2  2  2  2  2  2  2  2  2  2  2  1  2  1     1  1  2  2        2  1      |     42  1.9|
      Necrosis                             | 3                                                                        |      1  3.0|
      Atrium, Thrombosis                   |                         2                 4                          3   |      5  2.8|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                                                      3   |      1  3.0|
      Hyperplasia                          |       2  2  2  2     2  2  2  2  2  2        2  2  2  2  1  2  2         |     30  1.9|
      Hypertrophy                          |    2  2                             1                                    |      7  1.9|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          | 2  3  2  2     3  3  2        1           3     2        2  4  3     2   |     26  2.3|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +   |  45        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |    3                                                                     |      1  3.0|
      Pars Distalis, Hyperplasia           | 3                    4  4                                      3         |     11  3.2|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +   |  46        |
      C-Cell, Hyperplasia                  |       2  1  1  1  3     2  3  2     2  1  1     2           2  2     1   |     32  1.6|
      Follicular Cell, Hyperplasia         |                                                                          |      2  2.5|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |       3                                                        4         |      2  3.5|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |             3  3              2                       3     3            |     11  2.4|
      Inflammation, Chronic Active         |                                                                          |      3  3.3|
      Epithelium, Hyperplasia              |                                                                      4   |      1  4.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +   |  47        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |             3     4                                                      |      2  3.5|
      Interstitial Cell, Hyperplasia       |                1                       3  1                              |      5  1.6|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 4| 7| 7| 6| 7|  |            |
                             DAY ON TEST   | 3| 6| 3| 3| 3| 1| 2| 3| 2| 3| 3| 3| 3| 6| 7| 1| 3| 6| 3| 6| 0| 3| 5| 3|  |            |
                                           | 3| 0| 3| 4| 4| 5| 4| 3| 1| 3| 4| 4| 4| 0| 7| 5| 3| 0| 4| 0| 9| 3| 8| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +                                                        +            |   3        |
      Iliac, Hemorrhage                    |    2                                                                     |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  M  M  +  M  +  +  +   |  29        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +   |  40        |
      Infiltration Cellular, Plasma Cell   |                                     3                                    |      1  3.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                        2                                 |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | M  +  M  +  +  M  +  +  M  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +   |  24        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Fibrosis                             |          2                                2     3     3     2            |      7  2.1|
      Hematopoietic Cell Proliferation     |    3                                                     2           4   |      4  3.0|
      Hemorrhage                           |                                                 2                        |      3  2.3|
      Necrosis                             |                   4                                                      |      3  3.3|
      Thrombosis                           |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  +  +  M  M  +  I  +  M  +  +  M  +  +  M  +  M  M  +  M  +   |  21        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hyperkeratosis                       |    4                                      3        4                     |      4  3.5|
      Inflammation, Chronic Active         |                                                    3                     |      4  2.8|
      Epithelium, Hyperplasia, Basal Cell  |                      3                                                   |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Degeneration                         |                                        2                                 |      1  2.0|
      Artery, Inflammation                 |                                                                          |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Foreign Body                         |                                                                          |      1     |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 6| 7| 4| 7| 7| 6| 7|  |            |
                             DAY ON TEST   | 3| 6| 3| 3| 3| 1| 2| 3| 2| 3| 3| 3| 3| 6| 7| 1| 3| 6| 3| 6| 0| 3| 5| 3|  |            |
                                           | 3| 0| 3| 4| 4| 5| 4| 3| 1| 3| 4| 4| 4| 0| 7| 5| 3| 0| 4| 0| 9| 3| 8| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      A     |
    CONTROL                                | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                   1                                                      |      2  1.0|
      Inflammation, Granulomatous          |                                                                          |      1  4.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Thrombosis                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     | 3        2  1        1     1        1           2     1        1  4  1   |     23  1.7|
      Alveolar Epithelium, Metaplasia      |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1           1        1           1     1     1  1     1  1               |     12  1.0|
      Bronchiole, Hyperplasia              |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Foreign Body                         |                                        X                                 |      1     |
      Inflammation, Suppurative            |                   3                 2  3  3     3                 2      |     12  2.4|
      Thrombosis                           |                         4                 4                              |      6  3.5|
      Glands, Hyperplasia                  |                                                                          |      1  1.0|
      Olfactory Epithelium, Atrophy        |                   1                 1  2                                 |      3  1.3|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         |                                                                          |      3  1.3|
      Respiratory Epithelium, Hyperplasia  |                                     1                                    |      3  1.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Cataract                             |                                                                   2      |      4  2.8|
      Inflammation, Suppurative            |                                        4                                 |      1  4.0|
      Retina, Atrophy                      |                                                                          |      2  3.5|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Infarct                              |                                                                          |      3  3.0|
      Nephropathy                          | 2     4  2  2  2  2  2  1  2  1  1  1     2  2  1  2  3  1  2  2  2  2   |     43  1.9|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hemorrhage                           |                                                                          |      1  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 5| 5| 7| 7| 3| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 8| 3| 3| 5| 4| 3| 8| 3| 0| 8| 3| 3| 3| 8| 4| 9| 2| 3| 3| 9| 6| 3| 1| 3|             
                                           | 6| 4| 3| 3| 1| 3| 3| 4| 3| 2| 1| 3| 4| 3| 1| 3| 3| 5| 3| 4| 0| 5| 3| 5| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X  X  X     X  X  X        X  X  X     X        X  X     X  X  X  X|             
      Clear Cell Focus                     |       X  X                       X  X  X              X  X               |             
      Degeneration, Cystic                 |                                     2                                   2|             
      Eosinophilic Focus                   |                                                                   X      |             
      Fatty Change                         |                            3                                             |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
      Mixed Cell Focus                     |                                  X                                       |             
      Regeneration                         |                                                                      3   |             
      Bile Duct, Hyperplasia               | 2  1     1  2  3  1           2  2  2           2     1        1     1  2|             
      Centrilobular, Necrosis              | 1              2     2                                               1   |             

                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                +               |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Inflammation                    |                                                          3               |             
      Fat, Necrosis                        |                         2                                                |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  2  1  1  1     2  1  3              2  2|             
      Basophilic Focus                     |                                  X                                       |             
      Hyperplasia                          |       2                                                                 2|             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         2                                                |             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                            2                                             |             
      Ulcer                                |                3                                   3                     |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Necrosis                             |                2                                                         |             
      Ulcer                                |                                                                          |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                              +     +                     |             
      Inflammation, Chronic Active         |                                                    3                     |             
      Malformation                         |                                              X                           |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 5| 5| 7| 7| 3| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 8| 3| 3| 5| 4| 3| 8| 3| 0| 8| 3| 3| 3| 8| 4| 9| 2| 3| 3| 9| 6| 3| 1| 3|             
                                           | 6| 4| 3| 3| 1| 3| 3| 4| 3| 2| 1| 3| 4| 3| 1| 3| 3| 5| 3| 4| 0| 5| 3| 5| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Cardiomyopathy                       | 2  2  3  3  1  3  2  2  2     2  2  2  2  2  2  3  1  1  3  1  3  2  1  1|             
      Atrium, Thrombosis                   |                2     1                                                   |             
      Valve, Thrombosis, Chronic           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          | 1  2  3  2     2  2  2  2        2  2  2     2  2     2  2        2      |             
      Hypertrophy                          |                3                    2           2                        |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                      3   |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 4  3           3                    2  3        2     1              4   |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         4                                                |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           | 3     2        4              1  3           4  2                       4|             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1     3     1  1  1  2     2     1  1     1  1  1     4     1  2     1|             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Tissue NOS                              |       +                                                                  |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Granuloma Sperm                      |                                                                          |             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                          3        1     2|             
      Inflammation, Chronic Active         |                            4                                             |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             4                       4                             3      |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Interstitial Cell, Hyperplasia       |             1        1  1                 2        1           1  2      |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 5| 5| 7| 7| 3| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 8| 3| 3| 5| 4| 3| 8| 3| 0| 8| 3| 3| 3| 8| 4| 9| 2| 3| 3| 9| 6| 3| 1| 3|             
                                           | 6| 4| 3| 3| 1| 3| 3| 4| 3| 2| 1| 3| 4| 3| 1| 3| 3| 5| 3| 4| 0| 5| 3| 5| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  M  +  M  +  M  +  M  +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                              4                           |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  M  +  +  +  M  M  M  M  +  M  M  M  +  M  +  +  +  +  +  +  M  M  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       2              2     2     2              1                    3  2|             
      Hematopoietic Cell Proliferation     |    3                                                                     |             
      Hemorrhage                           |                            4                                             |             
      Necrosis                             |                2                                                         |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  I  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  M  +  M  M  M  M  I  M  +  M  +  M  M  M  +  M  +  M  M  +|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                          +               |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 | 2                                                                        |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst, Squamous                       |                                                                          |             
      Inflammation, Chronic Active         |    1                             1  1  1  1  1                    1      |             
      Inflammation, Suppurative            |                                                                      2   |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |    1     1        1                          1     4  3           3      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         1           1     1  1                 1         |             
      Bronchiole, Hyperplasia              |                         1                                                |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    2     2     1                       2  2  2     2     2        1      |             
      Thrombosis                           |                      2     2  1                    4                     |             
      Glands, Hyperplasia                  | 2  3  2  2  2  3  2  3  2  3  3  1  3  2  1  2  2  3  2  2  1  3  2  2  2|             
      Glands, Metaplasia, Squamous         |                                                                         4|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 6| 7| 6| 7| 5| 6| 7| 7| 7| 6| 6| 5| 5| 7| 7| 3| 6| 7| 6| 7|             
                             DAY ON TEST   | 2| 8| 3| 3| 5| 4| 3| 8| 3| 0| 8| 3| 3| 3| 8| 4| 9| 2| 3| 3| 9| 6| 3| 1| 3|             
                                           | 6| 4| 3| 3| 1| 3| 3| 4| 3| 2| 1| 3| 4| 3| 1| 3| 3| 5| 3| 4| 0| 5| 3| 5| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    10 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     |    1  1           2     1           1  2     1  1  1  1  2     1  1     2|             
      Olfactory Epithelium, Atrophy        | 2  2  2  2  3  2  2  3  2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  2  2  2  1  1  2  2  2     1  2  2  1  1     2  1  2  2  1  1  2  3  4|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Atypical                        | 2  3  2  2  3  3  2  3  2  2  2  2  2  2  3  1  2  2  2  2  2  2  2  2  1|             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic                         | 2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  1  2  2  2  2|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         |                         2           1     1     1     1  1              1|             
      Respiratory Epithelium, Hyperplasia  |       4  2     1        1        4                 2     1        1  1   |             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        | 2              2  1                                3           2         |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  2  4  3  1  2  2  2  3     2  2  2  3  1  2  2  1  3  2     4  3  1  2|             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 4| 5| 6| 7| 6| 7| 5| 7|  |            |
                             DAY ON TEST   | 8| 3| 0| 4| 3| 0| 7| 1| 3| 3| 4| 3| 3| 0| 3| 3| 3| 6| 9| 3| 7| 3| 2| 3|  |            |
                                           | 0| 4| 0| 3| 3| 0| 7| 3| 4| 3| 8| 3| 3| 5| 4| 4| 5| 7| 5| 4| 8| 4| 0| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|  |      A     |
    10 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                            1                                             |      1  1.0|
      Basophilic Focus                     |    X        X     X  X  X  X  X  X  X     X  X        X  X     X     X   |     31     |
      Clear Cell Focus                     |             X           X  X        X     X  X                 X         |     14     |
      Degeneration, Cystic                 |                                              2                           |      3  2.0|
      Eosinophilic Focus                   |                      X                                                   |      2     |
      Fatty Change                         |                                                          4               |      2  3.5|
      Hepatodiaphragmatic Nodule           |                            X           X              X                  |      3     |
      Inflammation, Granulomatous          |                                                                3         |      1  3.0|
      Mixed Cell Focus                     |                            X                                             |      2     |
      Regeneration                         | 2                                                                        |      2  2.5|
      Bile Duct, Hyperplasia               | 2     1  3  1  2     2     2  2  1  1  1     2     2     1  3  1  2  1   |     32  1.7|
      Centrilobular, Necrosis              | 2        2           1                             3  4     3        1   |     11  2.0|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +                 +        +                                   +         |   6        |
      Fat, Hemorrhage                      | 2                                                                        |      1  2.0|
      Fat, Inflammation                    |                                                                          |      1  3.0|
      Fat, Necrosis                        |                   2        2                                   2         |      4  2.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              | 2     2           1  1     2              2                 2  2         |     17  1.7|
      Basophilic Focus                     |                                                                          |      1     |
      Hyperplasia                          |                               2                                          |      3  2.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia, Squamous                |                                                                      3   |      2  2.5|
      Ulcer                                | 4                                                        4  3        2   |      6  3.2|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Mineralization                       |                         1           1                                    |      2  1.0|
      Necrosis                             |                                                             3            |      2  2.5|
      Ulcer                                |                   3                                                      |      1  3.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 4| 5| 6| 7| 6| 7| 5| 7|  |            |
                             DAY ON TEST   | 8| 3| 0| 4| 3| 0| 7| 1| 3| 3| 4| 3| 3| 0| 3| 3| 3| 6| 9| 3| 7| 3| 2| 3|  |            |
                                           | 0| 4| 0| 3| 3| 0| 7| 3| 4| 3| 8| 3| 3| 5| 4| 4| 5| 7| 5| 4| 8| 4| 0| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|  |      A     |
    10 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Malformation                         |                                                                          |      1     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cardiomyopathy                       | 1  2  2  2  3     2  2     2     1  2  1  1  2  1  2  2  2     1  1  3   |     44  1.9|
      Atrium, Thrombosis                   |                                                                          |      2  1.5|
      Valve, Thrombosis, Chronic           |          3                                                               |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                                       3                  |      1  3.0|
      Degeneration, Cystic                 |                                                       3  2               |      2  2.5|
      Hyperplasia                          |    2     1  2        2  3  1     2  2     2  2                 2     2   |     28  2.0|
      Hypertrophy                          | 2                                         2                    2         |      6  2.2|
      Necrosis                             |                                                       2                  |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |                   2  2              4     2  2                           |     13  2.6|
      Necrosis                             |                3                                                         |      1  3.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +   |  42        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cyst                                 |                                              2                           |      1  2.0|
      Pars Distalis, Hyperplasia           | 2              4              2                       3                  |     12  2.8|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +   |  47        |
      C-Cell, Hyperplasia                  | 1     1     1  2  1  1     3  1  1  1     1  2  1     1  2  2  2  1  2   |     36  1.4|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                                                3         |      1  3.0|
      Granuloma Sperm                      |                                                                2         |      1  2.0|

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |       3                    3              2           1  1               |      8  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 4| 5| 6| 7| 6| 7| 5| 7|  |            |
                             DAY ON TEST   | 8| 3| 0| 4| 3| 0| 7| 1| 3| 3| 4| 3| 3| 0| 3| 3| 3| 6| 9| 3| 7| 3| 2| 3|  |            |
                                           | 0| 4| 0| 3| 3| 0| 7| 3| 4| 3| 8| 3| 3| 5| 4| 4| 5| 7| 5| 4| 8| 4| 0| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|  |      A     |
    10 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                      4   |      2  4.0|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |                                                                      3   |      4  3.5|
      Artery, Inflammation, Chronic Active |                         2        2                                       |      2  2.0|
      Interstitial Cell, Hyperplasia       |    2                                                        1            |      9  1.3|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              +     +                                                   |   3        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  +  M  +  M  +  M  +  M  +  +  +  +  M  +  +  +  +   |  36        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +   |  45        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  M  +  M  +  M  M  +  M  +  M  +  +  +  M  M  +  +  +  M  +  M  +  +   |  28        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Fibrosis                             |          3           2        2                             3  2         |     12  2.2|
      Hematopoietic Cell Proliferation     |                                                       3              2   |      3  2.7|
      Hemorrhage                           |                                                                          |      1  4.0|
      Necrosis                             |                               3                                          |      2  2.5|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  M  +  M  M  M  M  +  +  +  +  M  M  M  +  M  +  M  +  M  M  +   |  20        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hyperkeratosis                       |                      4                                4                  |      2  4.0|
      Inflammation, Acute                  |                                                                      2   |      1  2.0|
      Inflammation, Chronic Active         |                                                       2                  |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                +                                                         |   1        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 4| 5| 6| 7| 6| 7| 5| 7|  |            |
                             DAY ON TEST   | 8| 3| 0| 4| 3| 0| 7| 1| 3| 3| 4| 3| 3| 0| 3| 3| 3| 6| 9| 3| 7| 3| 2| 3|  |            |
                                           | 0| 4| 0| 3| 3| 0| 7| 3| 4| 3| 8| 3| 3| 5| 4| 4| 5| 7| 5| 4| 8| 4| 0| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|  |      A     |
    10 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Metaplasia, Squamous                 |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cyst, Squamous                       |                               2                                          |      1  2.0|
      Inflammation, Chronic Active         |                1        1  1              1           1        1         |     13  1.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Thrombosis                           | 1                                                                        |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |    1                    1     2                          3     2         |     12  1.9|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      | 1                             1  1  1                                    |      9  1.0|
      Bronchiole, Hyperplasia              |                                                                          |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Inflammation, Suppurative            |                1  1  2        2              2        1  2     1     2   |     18  1.7|
      Thrombosis                           | 4                                                  4        4            |      7  3.0|
      Glands, Hyperplasia                  | 3  1  2  2  2  2  2  2  2  3  3  2  2  1  2  3  2  2  2  2  2  3  2  2   |     49  2.2|
      Glands, Metaplasia, Squamous         |                            4     1                                       |      3  3.0|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |    1        2     1  2  2  1        1     1  1                 1  2      |     25  1.3|
      Olfactory Epithelium, Atrophy        | 2  2  2  2  3  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  3  2  2  3   |     49  2.1|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 1     1  1  1  2  1  3  3  3  2  1  2  1  2  2  1  1  2  2  2  2     1   |     46  1.7|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Atypical                        | 3  2  2     2  2  2  2  2  2  2  2  1  3  2  3  2  2  3  2  2  4  2  1   |     48  2.1|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic                         | 2  2  2  1  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2  2   |     49  2.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 1  1  2        1     1     1  1  1        1  1     1  1  2               |     20  1.2|
      Respiratory Epithelium, Hyperplasia  | 3        1     1  3  4  4  1              4        1  2     2        3   |     21  2.2|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 3        2  2  2     2              1  2           2  2     3            |     15  2.1|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Cataract                             |                                  3           2                           |      2  2.5|
      Retina, Atrophy                      |                                  4                                       |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Nephropathy                          | 2  2  2  1  3  2  2  2  3  2  1  4  2     3  3        1  3  1  2  2  4   |     44  2.2|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 7| 7| 4| 5| 6| 7| 6| 7| 5| 7|  |            |
                             DAY ON TEST   | 8| 3| 0| 4| 3| 0| 7| 1| 3| 3| 4| 3| 3| 0| 3| 3| 3| 6| 9| 3| 7| 3| 2| 3|  |            |
                                           | 0| 4| 0| 3| 3| 0| 7| 3| 4| 3| 8| 3| 3| 5| 4| 4| 5| 7| 5| 4| 8| 4| 0| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|  |      A     |
    10 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 7| 7| 6| 7| 5| 0| 7| 7| 7| 4| 6| 6| 7| 7| 7| 5| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 6| 8| 1| 3| 1| 3| 4| 2| 3| 3| 3| 8| 3| 6| 3| 3| 3| 8| 2| 0| 2|             
                                           | 3| 3| 3| 5| 0| 1| 0| 4| 3| 4| 7| 9| 3| 4| 4| 9| 0| 3| 4| 3| 4| 2| 8| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  I  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +     +  +  +  A  +  +  +  +  +  +  A  +  A|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  A  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     1                                    |             
      Basophilic Focus                     | X  X     X     X     X     X           X  X  X           X  X     X      |             
      Clear Cell Focus                     |    X                 X     X        X                       X            |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |       X                                                                  |             
      Fatty Change                         |             2              1                                             |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis                             |                                                                          |             
      Regeneration                         |                                                                          |             
      Tension Lipidosis                    |                               X                                          |             
      Bile Duct, Hyperplasia               |    1  2  2  2  3     2  1  2  1     1     2     2  3  3        3        2|             
      Centrilobular, Necrosis              |          1                                         3                     |             

                                            __________________________________________________________________________|             
   Mesentery                               | +                 +     +  +                                         +   |             
      Artery, Mineralization               |                                                                          |             
      Fat, Necrosis                        | 2                 2     2  2                                         2   |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 2           1  1  1                                   4        1  1     2|             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          | 2                    2                                                   |             
      Artery, Inflammation                 |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |             2                 2                                          |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |             1  3                                                         |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             

                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             

                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 7| 7| 6| 7| 5| 0| 7| 7| 7| 4| 6| 6| 7| 7| 7| 5| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 6| 8| 1| 3| 1| 3| 4| 2| 3| 3| 3| 8| 3| 6| 3| 3| 3| 8| 2| 0| 2|             
                                           | 3| 3| 3| 5| 0| 1| 0| 4| 3| 4| 7| 9| 3| 4| 4| 9| 0| 3| 4| 3| 4| 2| 8| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2     2     2     2  2     2        2  2  2     2  1  2  2  2     2  1   |             
      Atrium, Thrombosis                   |                                                 3                        |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                      2                                                   |             
      Hyperplasia                          | 2  2  2        2  2  2     2        2     2                    2         |             
      Hypertrophy                          |       2                                   2           2                  |             
      Necrosis                             |                                                    2                     |             
      Vacuolization Cytoplasmic            |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2  2        1  1     3        2     2        3        1     2  1   |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3                                                      |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  M     +  +  +  +  M  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |          3              3           2                       4        3   |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  M  +  +  +  +  +  +     +  +  +  +  +  +  +  +  M  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1  1           2        2  1     2  1  2     3     1  1     1     1  2|             
      Follicular Cell, Hyperplasia         | 1                                                                        |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Peritoneum                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    3                                                                     |             
      Inflammation, Chronic Active         |                                                                         3|             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2              2  4  1     2        3               |             
      Inflammation, Chronic Active         |                                           3                              |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  A  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                1         |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |          +        +                       +           +                  |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  M  M  +  +     +  +  +  M  +  M  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  M  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 7| 7| 6| 7| 5| 0| 7| 7| 7| 4| 6| 6| 7| 7| 7| 5| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 6| 8| 1| 3| 1| 3| 4| 2| 3| 3| 3| 8| 3| 6| 3| 3| 3| 8| 2| 0| 2|             
                                           | 3| 3| 3| 5| 0| 1| 0| 4| 3| 4| 7| 9| 3| 4| 4| 9| 0| 3| 4| 3| 4| 2| 8| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  M  +  +  +     +  +  +  +  +  M  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                     2                                    |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |             4                                                            |             
      Necrosis                             |                                                                      2   |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +     +  +  M  +  +  +  M  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  +  M  +  +  M  M  +     M  +  +  M  M  +  +  +  +  +  +  M  M|             
      Galactocele                          |                                                                   2      |             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            | X                                                                        |             
      Hyperplasia, Basal Cell              |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                 2                        |             
      Necrosis                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                   1                                      1  1            |             
      Alveolar Epithelium, Hyperplasia     | 2     2                             1        2                           |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                     1                    1        1     1|             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       2     2              2        2     2  2     1  1  1  2        2   |             
      Thrombosis                           |             1                                   4  4                     |             
      Glands, Hyperplasia                  | 3  3  3  2  2  3  3  3  3  3  3     3  3  3  2  4  3  3  3  3  3  3  2  2|             
      Glands, Metaplasia, Squamous         |                   3  2     1                       3              2      |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     | 1  1  2        1     1  2  2        2  1  1           1  1  1           2|             
      Olfactory Epithelium, Atrophy        | 2  3  3  3  2  3  3  2  3  3  3     3  3  3  3  3  2  3  3  3  3  3  3  2|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 2  1  2  1     1  1  1  1  3  1     1  3  2     3  2  3  2  3     2  2  1|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 6| 7| 7| 6| 7| 5| 0| 7| 7| 7| 4| 6| 6| 7| 7| 7| 5| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 6| 8| 1| 3| 1| 3| 4| 2| 3| 3| 3| 8| 3| 6| 3| 3| 3| 8| 2| 0| 2|             
                                           | 3| 3| 3| 5| 0| 1| 0| 4| 3| 4| 7| 9| 3| 4| 4| 9| 0| 3| 4| 3| 4| 2| 8| 0| 3|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    30 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Atypical                        | 2  3  2  2  1  2  3  3  2  2  3     2  3  2  2  3  2  3  3  3  1  3  3  2|             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic                         | 2  2  3  2  2  2  2  2  2  2  2     2  2  2  2  2  2  3  2  3  2  3  2  2|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1     1        2           1        1  2        1  2                    1|             
      Respiratory Epithelium, Hyperplasia  | 2  2     1  2     1  3     1  4        1     2  2  2  3              2  3|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |       1  1  2  3                                3           1     2  3   |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                      2   |             
      Metaplasia, Osseous                  |                                     2                                    |             
      Nephropathy                          | 3  2  1  1     2  1  3  1  2  1     2  2  2  1  1  2  2  2  2  1  2  1  1|             
      Renal Tubule, Hyperplasia            |                                                                          |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 4| 3| 5| 3| 6| 8| 1| 0| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3| 3| 3| 8| 7| 3|  |            |
                                           | 3| 3| 0| 4| 3| 5| 5| 7| 3| 4| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 1| 4| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +   |  43        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +   |  45        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Angiectasis                          |                                                                          |      1  1.0|
      Basophilic Focus                     |    X     X  X  X        X  X  X     X  X     X     X  X  X  X     X  X   |     28     |
      Clear Cell Focus                     |    X     X                    X     X  X           X  X           X  X   |     14     |
      Degeneration, Cystic                 |                         2  2                                             |      2  2.0|
      Eosinophilic Focus                   |                                                                          |      1     |
      Fatty Change                         |       3                 2                                                |      4  2.0|
      Hepatodiaphragmatic Nodule           | X  X                                                                     |      2     |
      Mixed Cell Focus                     |          X  X                                                            |      2     |
      Necrosis                             |                2                                                         |      1  2.0|
      Regeneration                         |                      2                                                   |      1  2.0|
      Tension Lipidosis                    |                                                                          |      1     |
      Bile Duct, Hyperplasia               | 3        2           3     3  1     1     2  2     1        1  3     2   |     28  2.0|
      Centrilobular, Necrosis              | 1                    1     1              1     2                        |      7  1.4|

                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                      +              +  +               |   9        |
      Artery, Mineralization               |                                        3                                 |      1  3.0|
      Fat, Necrosis                        | 2                                                     2  2               |      8  2.0|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Atrophy                              |       2  3                 2  2        1           2  3     2  1         |     17  1.8|
      Basophilic Focus                     |    X                                                                     |      1     |
      Hyperplasia                          |                                                                          |      2  2.0|
      Artery, Inflammation                 |                               3                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hyperplasia, Squamous                |                                                                          |      2  2.0|
      Inflammation, Acute                  |       4                                                                  |      1  4.0|
      Ulcer                                |       4                                                                  |      3  2.7|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Inflammation, Acute                  |       4                                                                  |      1  4.0|
      Mineralization                       |    1                                                                     |      1  1.0|
      Necrosis                             | 2                                         2                              |      2  2.0|

                                            __________________________________________________________________________|____________|
   Tongue                                  |                                     +                                    |   1        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 4| 3| 5| 3| 6| 8| 1| 0| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3| 3| 3| 8| 7| 3|  |            |
                                           | 3| 3| 0| 4| 3| 5| 5| 7| 3| 4| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 1| 4| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Epithelium, Hyperplasia              |                                     1                                    |      1  1.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |       +                             +        +           +               |   4        |
      Inflammation, Chronic Active         |       3                             3        3           3               |      4  3.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Cardiomyopathy                       |    3     2  2  2     2  1  3  1  1  2  2  2  2  2  2  2  2  2  1  1  2   |     37  1.9|
      Atrium, Thrombosis                   | 3                          3                                             |      3  3.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia                          |    2     2     2           2  2        2  2  1     2  2  2        1  2   |     23  1.9|
      Hypertrophy                          |                2  2                    2              2  1           2   |      9  1.9|
      Necrosis                             |                                                 3                        |      2  2.5|
      Vacuolization Cytoplasmic            | 2  2                    2                                                |      3  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Hyperplasia                          | 2  3     3     1     3  2     2        2  2  2           2     2         |     23  2.0|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hyperplasia                          |                         2                                                |      2  2.5|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  M  +  +  +  +  +  +  +   |  42        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Pars Distalis, Hyperplasia           |    1                       3  3                 2                    2   |     10  2.6|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +   |  45        |
      C-Cell, Hyperplasia                  |    2  1     1        1  1  1  2     2  1  2        1  1  2  1  2     3   |     31  1.5|
      Follicular Cell, Hyperplasia         |                               1              3                           |      3  1.7|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Peritoneum                              |       +                                                                  |   1        |
      Inflammation, Suppurative            |       3                                                                  |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +   |  47        |
      Cyst                                 |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                      3   |      2  3.0|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hyperplasia                          |                      4     3  3     1  1           2  1     2  2     2   |     16  2.2|
      Inflammation, Chronic Active         | 3                                         3                              |      3  3.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 4| 3| 5| 3| 6| 8| 1| 0| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3| 3| 3| 8| 7| 3|  |            |
                                           | 3| 3| 0| 4| 3| 5| 5| 7| 3| 4| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 1| 4| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Atrophy                              |          4              4                                                |      2  4.0|
      Interstitial Cell, Hyperplasia       |                                  2                                       |      2  1.5|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                   +  +                    +                    +         |   8        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  +  M  +  M  M  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +   |  38        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  46        |
      Infiltration Cellular, Plasma Cell   |                         4                                                |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  44        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Fibrosis                             |    1                 2  1                          2           2         |      6  1.7|
      Hematopoietic Cell Proliferation     |                         3                                                |      1  3.0|
      Hemorrhage                           |                   3                                                      |      2  3.5|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +   |  43        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  M  M  +  +  M  M  +  +  M  M  +  +   |  30        |
      Galactocele                          |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperplasia, Basal Cell              |                            2                                             |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Osteopetrosis                        |                      3                                                   |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Degeneration                         |                                                                          |      1  2.0|
      Necrosis                             |                            2                                             |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Metaplasia, Squamous                 |                            2                             3               |      2  2.5|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 4| 3| 5| 3| 6| 8| 1| 0| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3| 3| 3| 8| 7| 3|  |            |
                                           | 3| 3| 0| 4| 3| 5| 5| 7| 3| 4| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 1| 4| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Inflammation, Chronic Active         |                1                    1  1                                 |      6  1.0|
      Alveolar Epithelium, Hyperplasia     |       3  1     1                    1                       1            |      9  1.6|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                1     1                                                   |      6  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Inflammation, Suppurative            | 2     2        2                                            2     1      |     16  1.8|
      Thrombosis                           | 4                          1                    3                        |      6  2.8|
      Glands, Hyperplasia                  | 3  2  2  4  2  3  3  3  2  4  4  2  2  4  3  3  3  3  3  3  3  3  3  3   |     48  2.9|
      Glands, Metaplasia, Squamous         | 1        2     2                       4  2        2  2  2  2            |     14  2.1|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |    1  1        1        1  1  1  1  2  1     1     1  1  2  1        1   |     29  1.2|
      Olfactory Epithelium, Atrophy        | 3  3  3  3  3  2  3  3  3  3  3  3  2  3  3  3  2  3  3  4  3  3  2  3   |     48  2.8|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 1        1     1  1  2  1  3  2     2  2  1  2  3  1  2  1  1  1     3   |     40  1.7|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Atypical                        | 3  2  3  2  3  2  3  3  2  3  3     2  4  2     2  2  3     2  3  3  3   |     45  2.5|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic                         | 2  2  2  2  2  2  3  3  2  2  2  2  2  3  2  3  2  2  3  2  2  2  2  2   |     48  2.2|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         |          1     1     1  1  2              2  1  2     2              1   |     19  1.4|
      Respiratory Epithelium, Hyperplasia  | 2     4     1     2  2        4     2     2  1        2  2  2  1     1   |     29  2.0|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        | 3           1  2  2  3     2  2  2        3     1     2  2     2  2  2   |     23  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Inflammation, Suppurative            |                                              2                           |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Cataract                             |                                              2                           |      1  2.0|
      Retina, Atrophy                      |                                              3                           |      1  3.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                         +                                                |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Infarct                              |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Nephropathy                          | 1  3  4  2  1  3     3  2  1  2  1  2  1  2  2     2  1  3  2  1  1  1   |     45  1.8|
      Renal Tubule, Hyperplasia            |       2                                                                  |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 7| 5| 6| 6| 7| 7| 7| 7| 4| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 5| 7|  |            |
                             DAY ON TEST   | 4| 3| 5| 3| 6| 8| 1| 0| 3| 3| 3| 3| 3| 3| 4| 7| 1| 3| 3| 3| 3| 8| 7| 3|  |            |
                                           | 3| 3| 0| 4| 3| 5| 5| 7| 3| 4| 3| 3| 3| 4| 3| 7| 3| 3| 3| 3| 3| 1| 4| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      A     |
    30 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 2| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 6| 3| 1| 8| 3| 5| 6| 3| 2| 7| 2| 3| 4| 6| 3| 3| 8| 3| 3| 3| 3| 3| 9|             
                                           | 3| 3| 0| 2| 2| 5| 4| 9| 0| 3| 2| 1| 4| 3| 5| 9| 4| 3| 5| 4| 4| 4| 3| 3| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    60 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X  X     X  X  X     X  X  X        X  X     X  X  X  X  X  X  X  X  X|             
      Clear Cell Focus                     |    X              X                    X                    X  X         |             
      Degeneration, Cystic                 |                                                                          |             
      Eosinophilic Focus                   |                                                 X                        |             
      Fatty Change                         |                      1                       1                           |             
      Hepatodiaphragmatic Nodule           |                                     X                                    |             
      Mixed Cell Focus                     |                                     X                                X   |             
      Regeneration                         |                                                                          |             
      Syncytial Alteration                 |                                                                          |             
      Bile Duct, Hyperplasia               |          2  2  2     1        3     1        1  1  2              2  1   |             
      Centrilobular, Necrosis              |          2  1                                                            |             

                                            __________________________________________________________________________|             
   Mesentery                               |       +              +     +                    +                        |             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Fat, Necrosis                        |       2              3     3                    2                        |             

                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             2  1        2        1           2     2        2     2      |             
      Basophilic Focus                     |                                                                          |             
      Hyperplasia                          |                                        3                                 |             
      Duct, Cyst                           |                                                                          |             

                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
      Necrosis                             |                                              1                           |             
      Ulcer                                |                               3                                          |             

                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |                1                                                         |             
      Ulcer                                |                      3                                                   |             

                                            __________________________________________________________________________|             
   Tooth                                   |                         +                                   +            |             
      Malformation                         |                         X                                   X            |             

 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  1     2  2  3  1  2  3  2  1  2  3     2  3  1     2  3  3  2  2  1|             
      Atrium, Thrombosis                   |             3                                                            |             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 2| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 6| 3| 1| 8| 3| 5| 6| 3| 2| 7| 2| 3| 4| 6| 3| 3| 8| 3| 3| 3| 3| 3| 9|             
                                           | 3| 3| 0| 2| 2| 5| 4| 9| 0| 3| 2| 1| 4| 3| 5| 9| 4| 3| 5| 4| 4| 4| 3| 3| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    60 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                          4               |             
      Hyperplasia                          | 2  2              2  2  2  1  2     2  2     1  2     2  2  1  2  2  2   |             
      Hypertrophy                          |                2              2                                          |             
      Necrosis                             |          2                                                               |             

                                            __________________________________________________________________________|             
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          3  2     2        1                 1              3     2      |             

                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   3      |             

                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             

                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia           | 3  4     3                             3           3        2            |             

                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 2           2  1  1     1     2     1  1     1  2  2     2  1     2  1   |             

 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                4         |             
      Inflammation, Chronic Active         |                         3                                                |             

                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                2                 2  2            |             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  A  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             

                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Artery, Inflammation, Chronic Active |    3                                                                     |             
      Interstitial Cell, Hyperplasia       |          1                          2        2                 1         |             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node                              |                +              +                                          |             

                                            __________________________________________________________________________|             
   Lymph Node, Bronchial                   | +  +  +  +  +  +  M  +  M  +  +  +  +  M  M  +  +  +  M  +  +  +  M  +  M|             

                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +|             
      Infiltration Cellular, Plasma Cell   |                         4                                                |             

                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lymph Node, Mediastinal                 | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             

                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 2| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 6| 3| 1| 8| 3| 5| 6| 3| 2| 7| 2| 3| 4| 6| 3| 3| 8| 3| 3| 3| 3| 3| 9|             
                                           | 3| 3| 0| 2| 2| 5| 4| 9| 0| 3| 2| 1| 4| 3| 5| 9| 4| 3| 5| 4| 4| 4| 3| 3| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    60 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             | 2           2        1                             2                     |             
      Hematopoietic Cell Proliferation     |                      3                                         2         |             
      Hemorrhage                           |                                  3                                       |             
      Necrosis                             |                2                                                         |             
      Thrombosis                           |                                                                          |             

                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  +  +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  M  M  +  M  +  M|             

                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             

 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic Active         |       1           1        1  1     1           1              1         |             
      Inflammation, Granulomatous          |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      1     1  2                    1           1  1      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 1           1              1              1  1     1  1        1  1      |             

                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |    3        2     2        2  2  2           2              2            |             
      Thrombosis                           |             3                                                            |             
      Glands, Hyperplasia                  | 4  3  3  4  4  3  4  4  4  4  4  3  4  3     3  3  3  3  4  4  3  4  3  3|             
      Glands, Metaplasia, Squamous         | 2  1  3  2  3  3     4     3  3  2                    2  2               |             
      Goblet Cell, Respiratory Epithelium, |                                                                          |             
           Hyperplasia                     | 2  1  1     1     1        1           2     1  1  2     1  1  1  1  1   |             
      Olfactory Epithelium, Atrophy        | 3  3  3  4  4  4  4  3  3  3  4  4  4  3        3  3  3  4  3  4  4  4  3|             
      Olfactory Epithelium, Degeneration,  |                                                                          |             
           Hyaline                         | 3  1  1  1  2     1  1     1  2  1  2  3     1  3  2  1  2  2  1     2  1|             
      Olfactory Epithelium, Hyperplasia,   |                                                                          |             
           Atypical                        | 3  3  3  3  2  3  2  3  4  3  3  3  2  2        2  2  4  3  4  3  3  3  2|             
      Olfactory Epithelium, Inflammation,  |                                                                          |             
           Chronic                         | 3  3  3  3  2  2  3  3  2  3  3  3  3  3     2  3  3  2  3  3  3  3  4  3|             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Hyaline                         | 1  2  1              1        1        2           1  1  1           1   |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 6| 7| 6| 5| 7| 7| 6| 6| 7| 2| 4| 7| 7| 6| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 6| 3| 1| 8| 3| 5| 6| 3| 2| 7| 2| 3| 4| 6| 3| 3| 8| 3| 3| 3| 3| 3| 9|             
                                           | 3| 3| 0| 2| 2| 5| 4| 9| 0| 3| 2| 1| 4| 3| 5| 9| 4| 3| 5| 4| 4| 4| 3| 3| 6|             

 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    60 PPM                                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |    2  3     1        1     3     2     1                       2  1  3  3|             
      Respiratory Epithelium, Metaplasia,  |                                                                          |             
           Squamous                        |    3     2  2  2                 2  2        4     1                     |             

                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Eye                                     | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cataract                             |       1                                                                  |             
      Hemorrhage                           |                                                                          |             
      Retina, Atrophy                      |                                                                          |             

                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                       +                  |             

 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             

                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                2                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Nephropathy                          | 2  3  4  1  1  2  2  3  1  2     2  3  2     1  2  2  1  2  1  1  3  2   |             
      Renal Tubule, Hyperplasia            |                                                                   2      |             

                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             

 _____________________________________________________________________________________________________________________|             
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 5| 7| 7| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 5| 7| 6| 6| 6| 7|  |            |
                             DAY ON TEST   | 0| 3| 6| 1| 9| 2| 3| 3| 5| 0| 3| 3| 3| 3| 5| 7| 3| 7| 2| 3| 0| 3| 0| 3|  |            |
                                           | 3| 3| 2| 9| 9| 6| 4| 4| 7| 7| 4| 9| 3| 3| 2| 2| 3| 5| 7| 3| 0| 9| 8| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|  |      A     |
    60 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Basophilic Focus                     | X  X              X        X  X  X  X  X  X     X        X           X   |     32     |
      Clear Cell Focus                     |    X              X                 X  X        X                    X   |     11     |
      Degeneration, Cystic                 |                            3                             1               |      2  2.0|
      Eosinophilic Focus                   |                   X                                                      |      2     |
      Fatty Change                         |                                  2        3                    2         |      5  1.8|
      Hepatodiaphragmatic Nodule           |                                                             X            |      2     |
      Mixed Cell Focus                     |                                                                          |      2     |
      Regeneration                         |                         2                                                |      1  2.0|
      Syncytial Alteration                 |                                                                2         |      1  2.0|
      Bile Duct, Hyperplasia               |    1           1     3  2  2                 1  2  1              2  2   |     21  1.7|
      Centrilobular, Necrosis              |                1                                            3            |      4  1.8|

                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +     +           +                    +   |   8        |
      Artery, Inflammation, Chronic Active |                                                                      2   |      1  2.0|
      Fat, Necrosis                        |                               2                 3                        |      6  2.5|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |                         2                 1     1  2        1  1         |     14  1.6|
      Basophilic Focus                     |                                     X                                    |      1     |
      Hyperplasia                          |                                                                          |      1  3.0|
      Duct, Cyst                           |                                                    4                     |      1  4.0|

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia, Squamous                |          2                                                               |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|
      Ulcer                                |                                                                2         |      2  2.5|

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Necrosis                             |                                                       2     2            |      3  1.7|
      Ulcer                                |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Malformation                         |                                                                          |      2     |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 5| 7| 7| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 5| 7| 6| 6| 6| 7|  |            |
                             DAY ON TEST   | 0| 3| 6| 1| 9| 2| 3| 3| 5| 0| 3| 3| 3| 3| 5| 7| 3| 7| 2| 3| 0| 3| 0| 3|  |            |
                                           | 3| 3| 2| 9| 9| 6| 4| 4| 7| 7| 4| 9| 3| 3| 2| 2| 3| 5| 7| 3| 0| 9| 8| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|  |      A     |
    60 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cardiomyopathy                       | 2  2  2  1  1  2  1  2     3  1  1  2  1  1  1  3  1     2  3        2   |     42  1.9|
      Atrium, Thrombosis                   |                                                             4            |      2  3.5|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Degeneration, Cystic                 |                                                                          |      1  4.0|
      Hyperplasia                          | 2  2  2  2  2  2  2        2        2  2  3  2  2  1  2  2     2  2  2   |     36  1.9|
      Hypertrophy                          |                            2  3                                          |      4  2.3|
      Necrosis                             |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |    2                       4           2                 2  4            |     12  2.3|

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |                                                                          |      1  3.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +   |  44        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Angiectasis                          |                                        3                                 |      1  3.0|
      Cyst                                 |                   3                                                      |      1  3.0|
      Pars Distalis, Hyperplasia           |          1  3     4  3  3              2        3  3  2                  |     15  2.8|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +   |  47        |
      C-Cell, Hyperplasia                  | 1        1     1  3     1  1     1  3     1  1  1  1  1  2  1  3  1  1   |     33  1.4|

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Cyst                                 |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                           2                              |      2  2.5|

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Hyperplasia                          |       2           1        1                 2                           |      8  1.8|
      Inflammation, Chronic Active         | 3                                                              4         |      2  3.5|

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  47        |
      Inflammation, Chronic Active         |                                                                3         |      1  3.0|

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Atrophy                              |                                        4     3                 3     3   |      4  3.3|
      Artery, Inflammation, Chronic Active |                                     3                                    |      2  3.0|
      Interstitial Cell, Hyperplasia       |    2  1  1                       1        1  1     1                     |     11  1.3|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 5| 7| 7| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 5| 7| 6| 6| 6| 7|  |            |
                             DAY ON TEST   | 0| 3| 6| 1| 9| 2| 3| 3| 5| 0| 3| 3| 3| 3| 5| 7| 3| 7| 2| 3| 0| 3| 0| 3|  |            |
                                           | 3| 3| 2| 9| 9| 6| 4| 4| 7| 7| 4| 9| 3| 3| 2| 2| 3| 5| 7| 3| 0| 9| 8| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|  |      A     |
    60 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node                              |                            +                          +                  |   4        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Bronchial                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  M  M  M   |  35        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +   |  44        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  4.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mediastinal                 | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  M  +  M  M  +   |  41        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Fibrosis                             |                         2                                            2   |      6  1.8|
      Hematopoietic Cell Proliferation     |                2                                            3            |      4  2.5|
      Hemorrhage                           |                                                       4                  |      2  3.5|
      Necrosis                             |                         2                                                |      2  2.0|
      Thrombosis                           |                            3                                             |      1  3.0|

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +   |  46        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  M  M  +  M  +  +  +  M  +  M  M  M  M  M  +  M  +  M  M   |  28        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Hyperkeratosis                       |                                                                2         |      1  2.0|
      Hyperplasia, Squamous                |                            2                                             |      1  2.0|

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Larynx                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Foreign Body                         |                                              X                           |      1     |
      Inflammation, Chronic Active         | 1  1              1           2        1  1              1     1         |     15  1.1|
      Inflammation, Granulomatous          |                                              3                           |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |       1  1        1  2     4        1           1  1  2        1         |     16  1.4|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    1                    1     1  1  3                                1   |     15  1.1|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05110-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                            NAPHTHALENE                                        Date: 03/06/00  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:08:03  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 4| 3| 5| 7| 7| 6| 7| 7| 5| 7| 7| 5| 5| 7| 5| 5| 7| 6| 6| 6| 7|  |            |
                             DAY ON TEST   | 0| 3| 6| 1| 9| 2| 3| 3| 5| 0| 3| 3| 3| 3| 5| 7| 3| 7| 2| 3| 0| 3| 0| 3|  |            |
                                           | 3| 3| 2| 9| 9| 6| 4| 4| 7| 7| 4| 9| 3| 3| 2| 2| 3| 5| 7| 3| 0| 9| 8| 3|  |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|  |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|  |      A     |
    60 PPM                                 | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|  |      L     |
                                           | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9|  |            |

 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                            1                                             |      9  2.0|
      Thrombosis                           |                                                             4     4      |      3  3.7|
      Glands, Hyperplasia                  | 3  3  4  4  2  4  4  4  3  3  4  4  4  4  4  4  3  3  3  4  4  3  4  3   |     48  3.5|
      Glands, Metaplasia, Squamous         | 4              2     3  2  2  4        4        3  1  2  2  2  2  3      |     26  2.5|
      Goblet Cell, Respiratory Epithelium, |                                                                          |            |
           Hyperplasia                     |    2           2  1  1              1  1  1  1     1     2           1   |     26  1.2|
      Olfactory Epithelium, Atrophy        | 4  4  3  3  4  3  4  3  3  4  4  3  4  4  4  3  3  3  4  3  3  3  3  4   |     47  3.5|
      Olfactory Epithelium, Degeneration,  |                                                                          |            |
           Hyaline                         | 2  1              1  2  2  1  2  1  1  2  2  1  1        1  1  2  1      |     38  1.5|
      Olfactory Epithelium, Hyperplasia,   |                                                                          |            |
           Atypical                        | 3  3  3  3     4  4  3  3  3  2  4  3  3  3  4  3  2  3  4  3  3  3  3   |     46  3.0|
      Olfactory Epithelium, Inflammation,  |                                                                          |            |
           Chronic                         | 3  4  3  3  3  3  4  3  3  3  3  3  4  3  3  3  3  2  3  4  3  4  3  3   |     48  3.0|
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Hyaline                         | 1  1        1  1  1  2  2     1                          1               |     19  1.2|
      Respiratory Epithelium, Hyperplasia  | 3  2     1  2  1  2  2     4  4     1  1  2     3        4  2  2  3  2   |     29  2.2|
      Respiratory Epithelium, Metaplasia,  |                                                                          |            |
           Squamous                        |       2        1        1  1     2        1           2     2  1  2      |     18  1.8|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  48        |
      Cataract                             |                      2                          3                        |      3  2.0|
      Hemorrhage                           |                         4                                                |      1  4.0|
      Retina, Atrophy                      |                         4                       4                        |      2  4.0|

                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Infarct                              |                         2                                      3         |      3  2.3|
      Inflammation, Suppurative            |                                                                4         |      1  4.0|
      Nephropathy                          | 3  2  2  1  1  1  2     2  3  3  1  4  2  2  1  2  1     2  2     1  3   |     43  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  49        |
      Transitional Epithelium, Hyperplasia |                                                                2         |      1  2.0|

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------