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TDMS Study 05111-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       1,2,3-TRICHLOROPROPANE


NTP Experiment-Test: 05111-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/14/94
Route: GAVAGE                                                                                                     Time: 05:10:26




       Facility:  TSI Mason Research

       Chemical CAS #:  96-18-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05111-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10            8            8                                     
  Early Deaths                                                                                                                      
    Moribund                                          17           17           42           50                                     
    Dead                                               2            2            2            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           30            8                                                  
  Wrong Sex                                                         1                                                               
  Animals Examined Microscopically                    60           59           60           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (58)         (59)         (60)         (60)                                   
      Hyperkeratosis                                   1 (2%)                   15 (25%)     31 (52%)                               
   Intestine Large, Cecum                             (59)         (57)         (59)         (59)                                   
      Atrophy                                                                                 2 (3%)                                
      Epithelium, Hyperplasia                                                                 1 (2%)                                
   Intestine Large, Colon                             (59)         (57)         (60)         (59)                                   
      Diverticulum                                                               1 (2%)                                             
   Liver                                              (60)         (59)         (60)         (60)                                   
      Basophilic Focus                                23 (38%)     29 (49%)     20 (33%)     10 (17%)                               
      Bile Stasis                                                                1 (2%)                                             
      Clear Cell Focus                                              1 (2%)       2 (3%)       1 (2%)                                
      Eosinophilic Focus                               1 (2%)       2 (3%)       2 (3%)       3 (5%)                                
      Fatty Change, Diffuse                            1 (2%)                                                                       
      Fatty Change, Focal                              3 (5%)       2 (3%)       2 (3%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Hepatodiaphragmatic Nodule                       2 (3%)       3 (5%)      11 (18%)      6 (10%)                               
      Hepatodiaphragmatic Nodule, Multiple             1 (2%)                                                                       
      Hyperplasia                                      2 (3%)       3 (5%)       1 (2%)       1 (2%)                                
      Inflammation, Granulomatous                      6 (10%)      5 (8%)                                                          
      Mineralization                                                                          1 (2%)                                
      Mitotic Alteration                                                         1 (2%)                                             
      Mixed Cell Focus                                 4 (7%)       6 (10%)      3 (5%)                                             
      Necrosis                                                      1 (2%)                    4 (7%)                                
      Bile Duct, Hyperplasia                                                     1 (2%)       5 (8%)                                
   Mesentery                                          (2)          (5)          (4)          (1)                                    
      Fat, Inflammation, Chronic Active                1 (50%)                                                                      
      Fat, Necrosis                                    1 (50%)      4 (80%)      3 (75%)                                            
   Pancreas                                           (60)         (59)         (60)         (60)                                   
      Acinus, Atrophy                                 10 (17%)      9 (15%)      9 (15%)      3 (5%)                                
      Acinus, Hyperplasia                              5 (8%)      15 (25%)     24 (40%)     11 (18%)                               
   Pharynx                                            (1)          (3)          (18)         (23)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05111-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hyperplasia, Squamous                                                      1 (6%)                                             
      Palate, Abscess                                                            1 (6%)       1 (4%)                                
      Palate, Hyperplasia, Basal Cell                  1 (100%)                  1 (6%)       1 (4%)                                
      Palate, Hyperplasia, Squamous                                              1 (6%)                                             
   Salivary Glands                                    (60)         (59)         (60)         (60)                                   
      Inflammation, Chronic Active                                                            1 (2%)                                
      Duct, Metaplasia, Squamous                                    5 (8%)       3 (5%)                                             
   Stomach, Forestomach                               (60)         (59)         (59)         (60)                                   
      Hyperplasia, Basal Cell                                      10 (17%)      5 (8%)       9 (15%)                               
      Hyperplasia, Squamous                            1 (2%)      26 (44%)     15 (25%)     16 (27%)                               
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                    1 (2%)                                
      Mineralization                                                2 (3%)                                                          
      Ulcer                                            1 (2%)       1 (2%)       2 (3%)       1 (2%)                                
   Stomach, Glandular                                 (60)         (59)         (60)         (59)                                   
      Hyperplasia                                                                             2 (3%)                                
      Mineralization                                                2 (3%)                    1 (2%)                                
   Tongue                                             (10)         (4)          (21)         (35)                                   
      Acanthosis                                                                              3 (9%)                                
      Hyperkeratosis                                                             1 (5%)       3 (9%)                                
      Hyperplasia, Squamous                                         1 (25%)                                                         
      Inflammation, Acute                                           1 (25%)      6 (29%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (60)         (58)                                   
      Cardiomyopathy                                  18 (30%)     22 (37%)     17 (28%)      9 (16%)                               
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (58)         (60)         (57)                                   
      Degeneration, Fatty                                           2 (3%)       1 (2%)                                             
      Hyperplasia                                                   2 (3%)       1 (2%)                                             
   Adrenal Gland, Medulla                             (59)         (56)         (59)         (57)                                   
      Hyperplasia                                      7 (12%)      5 (9%)       3 (5%)                                             
   Islets, Pancreatic                                 (60)         (58)         (60)         (60)                                   
      Hyperplasia                                                                1 (2%)                                             
      Metaplasia                                                    1 (2%)       2 (3%)       1 (2%)                                
   Pituitary Gland                                    (60)         (58)         (59)         (59)                                   
      Pars Distalis, Angiectasis                      19 (32%)     21 (36%)     11 (19%)      4 (7%)                                
      Pars Distalis, Cyst                             12 (20%)      7 (12%)     11 (19%)      1 (2%)                                
      Pars Distalis, Hyperplasia                      24 (40%)     22 (38%)     25 (42%)      7 (12%)                               
      Pars Intermedia, Cyst                                                      3 (5%)                                             
      Pars Intermedia, Hyperplasia                     1 (2%)                                                                       
   Thyroid Gland                                      (60)         (57)         (60)         (60)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05111-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      C-Cell, Hyperplasia                              7 (12%)      7 (12%)      8 (13%)                                            
      Follicle, Cyst                                                             1 (2%)                                             
      Follicle, Hemorrhage                             1 (2%)                                                                       
      Follicular Cell, Hyperplasia                                  3 (5%)       1 (2%)       2 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (56)         (56)         (58)         (59)                                   
      Hyperplasia                                                   2 (4%)       3 (5%)       3 (5%)                                
      Necrosis                                                                   3 (5%)                                             
   Ovary                                              (60)         (58)         (60)         (60)                                   
      Cyst                                             4 (7%)       3 (5%)       8 (13%)      3 (5%)                                
      Interstitial Cell, Hyperplasia                                                          1 (2%)                                
   Uterus                                             (60)         (58)         (60)         (60)                                   
      Cyst                                             2 (3%)                                                                       
      Decidual Reaction                                             1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Endometrium, Hyperplasia                         1 (2%)       1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (58)         (60)         (60)                                   
      Myelofibrosis                                    1 (2%)                                                                       
   Lymph Node                                         (60)         (59)         (60)         (60)                                   
      Mediastinal, Pigmentation                        3 (5%)       3 (5%)       5 (8%)                                             
      Pancreatic, Pigmentation                         2 (3%)                                                                       
   Lymph Node, Mandibular                             (58)         (57)         (60)         (58)                                   
      Degeneration                                                               4 (7%)                                             
   Lymph Node, Mesenteric                             (60)         (58)         (59)         (57)                                   
      Angiectasis                                      4 (7%)       2 (3%)                                                          
   Spleen                                             (60)         (57)         (60)         (59)                                   
      Angiectasis                                      1 (2%)                                                                       
      Depletion Lymphoid                                                                      3 (5%)                                
      Fibrosis                                         3 (5%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation                25 (42%)     27 (47%)     40 (67%)     32 (54%)                               
      Infiltration Cellular, Histiocyte                1 (2%)                    1 (2%)                                             
   Thymus                                             (56)         (56)         (59)         (57)                                   
      Depletion Lymphoid                                                                      2 (4%)                                
      Epithelial Cell, Hyperplasia                     1 (2%)                    4 (7%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05111-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (57)         (55)         (53)         (50)                                   
      Galactocele                                     11 (19%)     15 (27%)     11 (21%)      1 (2%)                                
   Skin                                               (60)         (59)         (59)         (59)                                   
      Acanthosis                                       1 (2%)       1 (2%)                                                          
      Hyperkeratosis                                   1 (2%)                                                                       
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Necrosis                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (59)         (60)         (59)                                   
      Hyperostosis                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (59)         (60)         (60)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Hydrocephalus                                                 1 (2%)                                                          
      Hyperplasia, Reticulum Cell                                                1 (2%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (58)         (59)         (60)                                   
      Edema                                            1 (2%)                                                                       
      Embolus Tumor                                                                           1 (2%)                                
      Fibrosis                                         1 (2%)       1 (2%)                                                          
      Infiltration Cellular, Histiocyte                5 (8%)       2 (3%)       5 (8%)                                             
      Inflammation, Acute                              1 (2%)                    2 (3%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (3%)       2 (3%)       2 (3%)       1 (2%)                                
   Nose                                               (60)         (59)         (60)         (60)                                   
      Fungus                                                                                  1 (2%)                                
      Inflammation, Acute                              2 (3%)       1 (2%)       2 (3%)       6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (5)          (11)         (19)                                   
      Hemorrhage                                       1 (25%)                                2 (11%)                               
      Inflammation, Acute                                                        2 (18%)      2 (11%)                               
      Synechia                                         1 (25%)      1 (20%)      2 (18%)                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05111-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Lens, Cataract                                                1 (20%)      3 (27%)      5 (26%)                               
      Retina, Atrophy                                               2 (40%)      4 (36%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (57)         (60)         (59)                                   
      Cyst                                             1 (2%)                                                                       
      Infarct                                                       1 (2%)                                                          
      Nephropathy                                     18 (30%)     21 (37%)     18 (30%)      8 (14%)                               
      Cortex, Mineralization                           1 (2%)       1 (2%)                    5 (8%)                                
      Papilla, Mineralization                          1 (2%)       1 (2%)                                                          
      Renal Tubule, Hyperplasia                                     2 (4%)       3 (5%)      12 (20%)                               
      Renal Tubule, Regeneration                                                              3 (5%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05111-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60           60                                     
  Scheduled Sacrifice                                                                         9                                     
  Early Deaths                                                                                                                      
    Moribund                                          13           16           30           43                                     
    Dead                                               2            2            4                                                  
    Accident                                           1                         1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           32           14                                                  
  Wrong Sex                                                                      1                                                  
  Animals Examined Microscopically                    60           60           59           60                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (59)         (59)         (59)                                   
      Hyperkeratosis                                   2 (3%)       3 (5%)       8 (14%)     35 (59%)                               
      Inflammation, Acute                              1 (2%)                                                                       
      Necrosis                                                                   1 (2%)       1 (2%)                                
   Intestine Large, Colon                             (60)         (60)         (58)         (60)                                   
      Edema                                            1 (2%)                                                                       
   Intestine Small, Duodenum                          (59)         (60)         (58)         (60)                                   
      Inflammation, Acute                                                        1 (2%)                                             
   Intestine Small, Ileum                             (59)         (60)         (57)         (59)                                   
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (59)         (60)         (57)         (60)                                   
      Diverticulum                                                                            1 (2%)                                
      Inflammation, Chronic Active                                               1 (2%)                                             
      Metaplasia, Osseous                                                        1 (2%)                                             
   Liver                                              (60)         (60)         (59)         (60)                                   
      Basophilic Focus                                12 (20%)      8 (13%)     18 (31%)     10 (17%)                               
      Clear Cell Focus                                 2 (3%)       5 (8%)       4 (7%)       5 (8%)                                
      Congestion                                       1 (2%)                                                                       
      Cyst                                                                                    1 (2%)                                
      Eosinophilic Focus                                            2 (3%)                    3 (5%)                                
      Fatty Change, Focal                             11 (18%)      9 (15%)      3 (5%)       1 (2%)                                
      Fibrosis                                         1 (2%)                                 1 (2%)                                
      Hepatodiaphragmatic Nodule                                    3 (5%)       6 (10%)      2 (3%)                                
      Hyperplasia                                                   1 (2%)                    2 (3%)                                
      Infarct                                                                                 2 (3%)                                
      Mixed Cell Focus                                 7 (12%)      8 (13%)      6 (10%)      7 (12%)                               
      Pigmentation                                     1 (2%)                                                                       
      Bile Duct, Hyperplasia                           1 (2%)       2 (3%)       6 (10%)     20 (33%)                               
   Mesentery                                          (5)          (9)          (12)         (5)                                    
      Fat, Fibrosis                                                              1 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05111-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fat, Hemorrhage                                                            1 (8%)                                             
      Fat, Inflammation, Chronic Active                1 (20%)                   1 (8%)       1 (20%)                               
      Fat, Mineralization                              1 (20%)      2 (22%)      4 (33%)                                            
      Fat, Necrosis                                                 4 (44%)      3 (25%)                                            
      Fat, Pigmentation                                             1 (11%)                   1 (20%)                               
   Pancreas                                           (60)         (60)         (59)         (60)                                   
      Acinus, Atrophy                                 10 (17%)     13 (22%)      8 (14%)      2 (3%)                                
      Acinus, Hyperplasia                             28 (47%)     46 (77%)     53 (90%)     57 (95%)                               
      Acinus, Hyperplasia, Multiple                                 2 (3%)                                                          
      Artery, Inflammation, Chronic Active             6 (10%)      2 (3%)       1 (2%)                                             
   Pharynx                                            (1)          (5)          (18)         (16)                                   
      Hyperplasia, Basal Cell                                                                 1 (6%)                                
      Hyperplasia, Squamous                                                                   1 (6%)                                
      Palate, Hyperplasia, Basal Cell                               1 (20%)                   2 (13%)                               
      Palate, Hyperplasia, Squamous                                              1 (6%)       1 (6%)                                
      Palate, Ulcer                                                              1 (6%)                                             
   Salivary Glands                                    (60)         (60)         (59)         (60)                                   
      Duct, Metaplasia, Squamous                                    1 (2%)       2 (3%)       6 (10%)                               
   Stomach, Forestomach                               (60)         (60)         (59)         (60)                                   
      Cyst Epithelial Inclusion                                     1 (2%)                                                          
      Hyperplasia, Basal Cell                                       7 (12%)     12 (20%)      9 (15%)                               
      Hyperplasia, Squamous                            3 (5%)      28 (47%)     13 (22%)      6 (10%)                               
      Inflammation, Chronic Active                     1 (2%)       1 (2%)       2 (3%)                                             
      Ulcer                                            1 (2%)       2 (3%)       7 (12%)      2 (3%)                                
   Stomach, Glandular                                 (60)         (60)         (59)         (60)                                   
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                                                             2 (3%)                                
      Mineralization                                                             1 (2%)                                             
   Tongue                                             (14)         (8)          (13)         (47)                                   
      Acanthosis                                                                 2 (15%)                                            
      Hyperkeratosis                                   3 (21%)      2 (25%)      1 (8%)       5 (11%)                               
      Hyperplasia, Basal Cell                          1 (7%)                                 2 (4%)                                
      Hyperplasia, Squamous                                         1 (13%)                                                         
      Inflammation, Acute                                                        1 (8%)      16 (34%)                               
      Inflammation, Chronic Active                                               1 (8%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (59)         (60)                                   
      Cardiomyopathy                                  39 (65%)     43 (73%)     37 (63%)     27 (45%)                               
      Fibrosis                                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05111-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (58)         (59)                                   
      Degeneration, Fatty                                           1 (2%)                                                          
      Hyperplasia                                                                1 (2%)       1 (2%)                                
   Adrenal Gland, Medulla                             (59)         (60)         (58)         (59)                                   
      Hyperplasia                                     10 (17%)      8 (13%)      9 (16%)      3 (5%)                                
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)                                   
      Hyperplasia                                      5 (8%)       2 (3%)       1 (2%)       2 (3%)                                
   Parathyroid Gland                                  (57)         (55)         (57)         (53)                                   
      Hyperplasia                                      1 (2%)                    1 (2%)       1 (2%)                                
   Pituitary Gland                                    (58)         (58)         (59)         (59)                                   
      Pars Distalis, Angiectasis                       7 (12%)     10 (17%)      3 (5%)       1 (2%)                                
      Pars Distalis, Cyst                              3 (5%)       1 (2%)       2 (3%)                                             
      Pars Distalis, Hyperplasia                       7 (12%)     11 (19%)     14 (24%)     10 (17%)                               
      Pars Distalis, Hyperplasia, Multifocal           1 (2%)                                                                       
      Pars Intermedia, Hyperplasia                                               1 (2%)                                             
   Thyroid Gland                                      (60)         (59)         (59)         (59)                                   
      C-Cell, Hyperplasia                              5 (8%)       3 (5%)       8 (14%)      4 (7%)                                
      Follicle, Cyst                                                1 (2%)       1 (2%)                                             
      Follicular Cell, Hyperplasia                                  1 (2%)       1 (2%)       4 (7%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (59)         (57)         (59)         (58)                                   
      Abscess                                          2 (3%)                                 2 (3%)                                
      Hyperplasia                                                                1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
   Prostate                                           (58)         (60)         (59)         (60)                                   
      Hyperplasia                                      7 (12%)      4 (7%)      10 (17%)      2 (3%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
   Testes                                             (60)         (60)         (59)         (60)                                   
      Interstitial Cell, Hyperplasia                  16 (27%)     14 (23%)     13 (22%)     24 (40%)                               
      Seminiferous Tubule, Atrophy                     5 (8%)       5 (8%)       3 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05111-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (59)         (60)                                   
      Myelofibrosis                                                 1 (2%)                                                          
   Lymph Node                                         (60)         (60)         (59)         (60)                                   
      Mediastinal, Angiectasis                         1 (2%)                    2 (3%)       1 (2%)                                
      Mediastinal, Infiltration Cellular,                                                                                           
          Polymorphonuclear                                                                   1 (2%)                                
      Mediastinal, Pigmentation                        1 (2%)       2 (3%)       2 (3%)       3 (5%)                                
   Lymph Node, Mandibular                             (60)         (60)         (58)         (60)                                   
      Angiectasis                                      1 (2%)                                                                       
      Degeneration                                     1 (2%)       1 (2%)       1 (2%)                                             
      Infiltration Cellular, Plasma Cell               1 (2%)                                 1 (2%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (59)         (57)         (59)                                   
      Angiectasis                                                   1 (2%)                                                          
      Degeneration                                                  1 (2%)                                                          
      Hemorrhage                                                                 1 (2%)                                             
      Infiltration Cellular, Histiocyte                1 (2%)                    1 (2%)                                             
   Spleen                                             (60)         (60)         (59)         (60)                                   
      Fibrosis                                         1 (2%)       5 (8%)       1 (2%)       2 (3%)                                
      Hematopoietic Cell Proliferation                15 (25%)     24 (40%)     31 (53%)     31 (52%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                1 (2%)                                                                       
      Mineralization                                                             1 (2%)                                             
      Pigmentation                                                  2 (3%)                                                          
   Thymus                                             (59)         (58)         (51)         (56)                                   
      Cyst                                                                                    1 (2%)                                
      Depletion Lymphoid                                                         1 (2%)       1 (2%)                                
      Epithelial Cell, Hyperplasia                     4 (7%)       2 (3%)                    2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (51)         (50)         (41)         (46)                                   
      Galactocele                                      1 (2%)       3 (6%)       2 (5%)                                             
      Hyperplasia                                                   1 (2%)                                                          
   Skin                                               (60)         (58)         (58)         (59)                                   
      Acanthosis                                                    1 (2%)                                                          
      Fibrosis                                         2 (3%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Hyperkeratosis                                                1 (2%)       2 (3%)       3 (5%)                                
      Inflammation, Chronic Active                     4 (7%)                                 1 (2%)                                
      Necrosis                                         2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05111-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (59)         (60)                                   
      Fibrous Osteodystrophy                                                     1 (2%)                                             
   Skeletal Muscle                                    (2)          (3)          (5)          (3)                                    
      Inflammation, Acute                                                        1 (20%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (59)         (60)                                   
      Edema                                                                      1 (2%)                                             
      Fibrosis                                         1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Infiltration Cellular, Histiocyte                1 (2%)       3 (5%)                                                          
      Inflammation, Acute                                                        4 (7%)       1 (2%)                                
      Alveolar Epithelium, Hyperplasia                                                        4 (7%)                                
      Mediastinum, Inflammation, Acute                 1 (2%)                                                                       
   Nose                                               (60)         (60)         (59)         (60)                                   
      Fungus                                           8 (13%)      6 (10%)      6 (10%)      1 (2%)                                
      Hyperkeratosis                                   1 (2%)                                                                       
      Inflammation, Acute                              7 (12%)      7 (12%)     10 (17%)      6 (10%)                               
      Nasolacrimal Duct, Inflammation, Acute                                     1 (2%)                                             
      Respiratory Epithelium, Hyperplasia              1 (2%)       3 (5%)                    1 (2%)                                
      Respiratory Epithelium, Metaplasia, Squamous     2 (3%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (2)          (7)          (8)                                    
      Synechia                                         1 (50%)                   1 (14%)      1 (13%)                               
      Lens, Cataract                                   1 (50%)      1 (50%)      4 (57%)      4 (50%)                               
      Retina, Atrophy                                                            1 (14%)                                            
   Harderian Gland                                                 (1)          (1)          (2)                                    
      Hemorrhage                                                    1 (100%)                                                        
      Hyperplasia                                                                1 (100%)                                           
   Zymbal's Gland                                                                            (4)                                    
      Necrosis                                                                                1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05111-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       1,2,3-TRICHLOROPROPANE                                  Date: 09/14/94  
Route: GAVAGE                                                                                                     Time: 05:10:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 MG/KG      3 MG/KG      10 MG/KG     30 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)         (60)                                   
      Cyst                                                          1 (2%)       3 (5%)                                             
      Hydronephrosis                                                             1 (2%)                                             
      Necrosis                                                      1 (2%)       1 (2%)                                             
      Nephropathy                                     58 (97%)     60 (100%)    58 (98%)     60 (100%)                              
      Bilateral, Hydronephrosis                                                  1 (2%)                                             
      Cortex, Mineralization                                                     3 (5%)                                             
      Renal Tubule, Hyperplasia                                     1 (2%)      23 (39%)     36 (60%)                               
      Renal Tubule, Hyperplasia, Eosinophil                                                   2 (3%)                                
   Urinary Bladder                                    (59)         (60)         (57)         (60)                                   
      Calculus Gross Observation                                    1 (2%)       1 (2%)       4 (7%)                                
      Calculus Micro Observation Only                  1 (2%)       1 (2%)       1 (2%)       4 (7%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
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