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TDMS Study 05114-01 Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)


NTP Experiment-Test: 05114-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/14/94
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:20




       Facility:  Battelle Northwest

       Chemical CAS #:  77-47-4

       Lock Date:  01/09/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05114-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          19           16           14           16                                     
    Dead                                               3            1            5            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                28           33           30           30                                     
  Wrong Sex                                                                      1                                                  
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (18)         (19)         (60)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
   Liver                                              (60)         (34)         (32)         (60)                                   
      Hepatocellular Carcinoma                                                   1 (3%)                                             
      Hepatocellular Adenoma                           1 (2%)       2 (6%)                                                          
      Hepatocellular Adenoma, Multiple                                                        1 (2%)                                
   Mesentery                                          (10)         (6)          (6)          (3)                                    
   Pancreas                                           (60)         (17)         (19)         (60)                                   
      Carcinoma, Metastatic, Kidney                    1 (2%)                                                                       
   Pharynx                                            (3)                       (1)                                                 
      Squamous Cell Carcinoma                          1 (33%)                   1 (100%)                                           
   Tongue                                             (1)          (1)          (1)                                                 
      Carcinoma                                        1 (100%)     1 (100%)                                                        
      Squamous Cell Carcinoma, Metastatic, Pharynx                               1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (17)         (19)         (60)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (21)         (19)         (60)                                   
      Carcinoma                                                     1 (5%)                                                          
   Adrenal Medulla                                    (57)         (19)         (20)         (59)                                   
      Pheochromocytoma Malignant                                    1 (5%)       1 (5%)                                             
      Pheochromocytoma Benign                          5 (9%)       2 (11%)      3 (15%)      2 (3%)                                
                                                             Page   2                                                               
NTP Experiment-Test: 05114-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (18)         (19)         (59)                                   
      Adenoma                                          2 (3%)       1 (6%)                    1 (2%)                                
   Pituitary Gland                                    (60)         (39)         (38)         (60)                                   
      Pars Distalis, Adenoma                          32 (53%)     30 (77%)     25 (66%)     40 (67%)                               
      Pars Intermedia, Adenoma                         2 (3%)       1 (3%)                    1 (2%)                                
      Pars Nervosa, Hamartoma                                       1 (3%)                                                          
   Thyroid Gland                                      (60)         (19)         (19)         (60)                                   
      C-Cell, Adenoma                                  6 (10%)      3 (16%)      1 (5%)       5 (8%)                                
      C-Cell, Carcinoma                                             1 (5%)       3 (16%)      4 (7%)                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                                    1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (22)         (27)         (60)                                   
      Carcinoma                                        5 (8%)       5 (23%)      3 (11%)      4 (7%)                                
   Ovary                                              (60)         (18)         (24)         (59)                                   
      Granulosa Cell Tumor Benign                      1 (2%)                                 1 (2%)                                
      Thecoma Malignant                                                                       1 (2%)                                
   Uterus                                             (60)         (22)         (59)         (60)                                   
      Adenocarcinoma                                                                          1 (2%)                                
      Polyp Stromal                                    3 (5%)       5 (23%)      5 (8%)       8 (13%)                               
      Sarcoma Stromal                                  1 (2%)                                                                       
      Bilateral, Polyp Stromal                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (17)         (19)         (60)                                   
   Lymph Node                                                      (2)          (1)          (3)                                    
   Lymph Node, Bronchial                              (44)         (17)         (16)         (51)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
   Lymph Node, Mandibular                             (58)         (18)         (18)         (59)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
   Lymph Node, Mesenteric                             (59)         (17)         (18)         (59)                                   
   Lymph Node, Mediastinal                            (57)         (18)         (18)         (54)                                   
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (6%)                                             
   Spleen                                             (60)         (21)         (26)         (60)                                   
   Thymus                                             (57)         (17)         (16)         (55)                                   
                                                             Page   3                                                               
NTP Experiment-Test: 05114-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (34)         (29)         (60)                                   
      Adenoacanthoma                                                1 (3%)                                                          
      Adenocarcinoma                                   2 (3%)       1 (3%)       4 (14%)      1 (2%)                                
      Adenocarcinoma, Multiple                         1 (2%)                                                                       
      Fibroadenoma                                    13 (22%)     14 (41%)     13 (45%)      8 (13%)                               
      Fibroadenoma, Multiple                                        6 (18%)      1 (3%)       5 (8%)                                
      Sarcoma                                                                                 1 (2%)                                
   Skin                                               (60)         (17)         (19)         (60)                                   
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Neurofibrosarcoma                                                          1 (5%)                                             
      Squamous Cell Papilloma                                                    1 (5%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (17)         (19)         (60)                                   
      Mandible, Squamous Cell Carcinoma,                                                                                            
          Metastatic, Pharynx                                                    1 (5%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (60)         (59)         (58)         (60)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
   Lung                                               (60)         (60)         (59)         (60)                                   
      Adenocarcinoma, Metastatic, Mammary Gland        1 (2%)                                                                       
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland                          1 (2%)                    1 (2%)                                
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
      Carcinoma, Metastatic, Adrenal Cortex                         1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic                                     1 (2%)                                             
   Trachea                                            (60)         (60)         (59)         (60)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05114-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (5)          (1)          (6)          (4)                                    
      Lids, Fibroma                                                              1 (17%)                                            
   Harderian Gland                                    (1)          (1)                                                              
      Adenoma                                          1 (100%)                                                                     
      Duct, Carcinoma                                               1 (100%)                                                        
   Zymbal's Gland                                     (1)          (1)                                                              
      Carcinoma                                        1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)         (60)                                   
      Carcinoma                                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            16 (27%)     14 (23%)     18 (30%)     21 (35%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05114-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          44          51                                       
     Total Primary Neoplasms                          100          93          83         107                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 46          44          39          48                                       
     Total Benign Neoplasms                            70          65          50          72                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              29          26          27          28                                       
     Total Malignant Neoplasms                         30          28          33          35                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2           3           1                                       
     Total Metastatic Neoplasm                          3           2           6           6                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05114-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund                                          27           30           23           31                                     
    Dead                                               5            4            5            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                18           16           22           16                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (57)         (34)         (25)         (59)                                   
   Intestine Large, Rectum                            (57)         (34)         (24)         (60)                                   
      Sarcoma                                                                                 1 (2%)                                
   Intestine Large, Cecum                             (58)         (32)         (23)         (59)                                   
   Intestine Small, Duodenum                          (57)         (34)         (26)         (60)                                   
   Intestine Small, Jejunum                           (56)         (33)         (23)         (58)                                   
      Adenocarcinoma, Mucinous                         1 (2%)                                                                       
      Fibroma                                          1 (2%)                                                                       
   Intestine Small, Ileum                             (56)         (32)         (24)         (58)                                   
   Liver                                              (60)         (42)         (36)         (60)                                   
      Hepatocellular Adenoma                           1 (2%)       1 (2%)       1 (3%)       3 (5%)                                
   Mesentery                                          (12)         (11)         (8)          (14)                                   
   Oral Mucosa                                                                               (1)                                    
      Squamous Cell Carcinoma                                                                 1 (100%)                              
   Pancreas                                           (60)         (34)         (30)         (60)                                   
   Pharynx                                                                      (3)                                                 
      Papilloma                                                                  1 (33%)                                            
      Squamous Cell Carcinoma                                                    1 (33%)                                            
   Stomach, Forestomach                               (60)         (36)         (30)         (60)                                   
   Stomach, Glandular                                 (60)         (35)         (30)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (34)         (27)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05114-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (33)         (27)         (60)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                                                  1 (4%)                                             
      Bilateral, Adenoma                                                                      1 (2%)                                
   Adrenal Medulla                                    (60)         (34)         (28)         (59)                                   
      Pheochromocytoma Malignant                       2 (3%)       1 (3%)       1 (4%)       1 (2%)                                
      Pheochromocytoma Benign                         12 (20%)      7 (21%)      6 (21%)     14 (24%)                               
      Pheochromocytoma Benign, Multiple                1 (2%)                                                                       
      Bilateral, Pheochromocytoma Benign               2 (3%)       3 (9%)       5 (18%)      4 (7%)                                
   Islets, Pancreatic                                 (60)         (34)         (29)         (60)                                   
      Adenoma                                          8 (13%)      5 (15%)      5 (17%)     11 (18%)                               
      Carcinoma                                        4 (7%)       2 (6%)       1 (3%)       2 (3%)                                
   Parathyroid Gland                                  (56)         (30)         (25)         (56)                                   
   Pituitary Gland                                    (60)         (39)         (38)         (59)                                   
      Carcinoma, Metastatic, Zymbal's Gland                         1 (3%)                                                          
      Pars Distalis, Adenoma                          27 (45%)     23 (59%)     23 (61%)     36 (61%)                               
   Thyroid Gland                                      (59)         (35)         (33)         (60)                                   
      C-Cell, Adenoma                                  5 (8%)       3 (9%)       5 (15%)      3 (5%)                                
      C-Cell, Carcinoma                                             1 (3%)       3 (9%)       3 (5%)                                
      Follicular Cell, Adenoma                                      1 (3%)                    3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (35)         (27)         (60)                                   
   Preputial Gland                                    (60)         (38)         (30)         (58)                                   
      Carcinoma                                        6 (10%)      2 (5%)       1 (3%)       2 (3%)                                
   Testes                                             (60)         (50)         (49)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           23 (38%)     21 (42%)     19 (39%)     19 (32%)                               
      Interstitial Cell, Adenoma                      14 (23%)     13 (26%)     13 (27%)     20 (33%)                               
      Interstitial Cell, Adenoma, Multiple            10 (17%)      2 (4%)       2 (4%)       5 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (34)         (27)         (60)                                   
   Lymph Node                                         (3)          (6)          (11)         (8)                                    
   Lymph Node, Bronchial                              (51)         (32)         (28)         (52)                                   
   Lymph Node, Mandibular                             (58)         (32)         (30)         (60)                                   
      Squamous Cell Carcinoma, Metastatic, Skin                                               1 (2%)                                
   Lymph Node, Mesenteric                             (59)         (35)         (31)         (60)                                   
                                                             Page   8                                                               
NTP Experiment-Test: 05114-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
   Lymph Node, Mediastinal                            (58)         (32)         (28)         (58)                                   
      Carcinoma, Metastatic, Thyroid Gland                                       1 (4%)                                             
   Spleen                                             (60)         (41)         (37)         (60)                                   
   Thymus                                             (56)         (32)         (28)         (59)                                   
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (38)         (34)         (60)                                   
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Fibroma                                          2 (3%)       1 (3%)       2 (6%)       3 (5%)                                
      Fibrosarcoma                                     1 (2%)       1 (3%)                                                          
      Neurofibroma                                                                            1 (2%)                                
      Neurofibrosarcoma                                                          1 (3%)       1 (2%)                                
      Sarcoma                                                                    1 (3%)                                             
      Squamous Cell Carcinoma                                                                 1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)       1 (3%)                    1 (2%)                                
      Sebaceous Gland, Carcinoma                                    1 (3%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)                       (2)          (2)                                    
      Rhabdomyosarcoma                                 1 (100%)                                                                     
      Sarcoma                                                                    1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (35)         (29)         (60)                                   
      Glioma Malignant                                                                        1 (2%)                                
      Granular Cell Tumor Malignant                                              1 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                     5 (8%)       2 (3%)       2 (3%)       3 (5%)                                
      Alveolar/Bronchiolar Carcinoma                                                          2 (3%)                                
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Carcinoma, Metastatic, Zymbal's Gland                         2 (3%)                                                          
      Hemangiosarcoma, Metastatic, Uncertain                                                                                        
          Primary Site                                                           1 (2%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle                                       1 (2%)                                             
                                                             Page   9                                                               
NTP Experiment-Test: 05114-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:20  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Squamous Cell Carcinoma, Metastatic, Skin                                               1 (2%)                                
   Nose                                               (58)         (60)         (59)         (60)                                   
      Adenoma, Papillary                                                                      1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                                 (1)          (2)          (2)                                    
      Adenoma                                                                                 1 (50%)                               
      Duct, Carcinoma                                               1 (100%)                                                        
   Zymbal's Gland                                     (2)          (2)          (1)          (1)                                    
      Carcinoma                                        2 (100%)     2 (100%)     1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (38)         (36)         (60)                                   
      Nephroblastoma                                                1 (3%)                                                          
   Urinary Bladder                                    (60)         (34)         (27)         (60)                                   
      Papilloma                                        1 (2%)                                                                       
                                                                                                                                    
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 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            29 (48%)     33 (55%)     26 (43%)     29 (48%)                               
      Mesothelioma Malignant                           1 (2%)       5 (8%)                    2 (3%)                                
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     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05114-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                 HEXACHLOROCYCLOPENTADIENE (HCCPD)                             Date: 09/14/94  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:27:20  
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         FISCHER 344 RATS MALE                     CONTROL      0.01 PPM     0.05 PPM     0.2                                       
                                                                                                                                    
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TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            60          51          52          59                                       
     Total Primary Neoplasms                          161         133         123         178                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 56          47          47          57                                       
     Total Benign Neoplasms                           114          83          84         130                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              36          38          34          34                                       
     Total Malignant Neoplasms                         47          50          39          48                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           4           3                                       
     Total Metastatic Neoplasm                          1           5           4           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
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a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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