National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3292

TDMS Study 05120-03 Pathology Tables



                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                           BENZYL ACETATE


NTP Experiment-Test: 05120-03                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/15/94
Route: DOSED FEED                                                                                                 Time: 13:39:17




       Facility:  Southern Research Institute

       Chemical CAS #:  140-11-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           17           13           19                                     
    Natural Death                                      2            3                         3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           30           37           28                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (60)         (60)         (60)         (60)                                   
   Intestine Small, Ileum                             (60)         (60)         (60)         (60)                                   
   Intestine Small, Jejunum                           (59)         (60)         (60)         (60)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Cholangiocarcinoma                                                         1 (2%)                                             
      Hepatocellular Carcinoma                                                                1 (2%)                                
      Hepatocellular Adenoma                           2 (3%)       1 (2%)       1 (2%)       3 (5%)                                
   Mesentery                                          (11)         (5)          (7)          (12)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (20%)                                                         
      Adenocarcinoma, Metastatic, Uterus               1 (9%)                                                                       
      Liposarcoma, Metastatic, Kidney                                                         1 (8%)                                
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
   Salivary Glands                                    (60)         (60)         (60)         (60)                                   
      Adenoma                                                                                 1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
   Tongue                                             (60)         (60)         (60)         (60)                                   
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Tooth                                              (1)          (3)          (1)                                                 
      Peridontal Tissue, Adenocarcinoma,                                                                                            
          Metastatic, Uncertain Primary Site                        1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Adenoma                                          3 (5%)       2 (3%)       1 (2%)       1 (2%)                                
   Adrenal Gland, Medulla                             (60)         (60)         (60)         (60)                                   
      Ganglioneuroma                                                             1 (2%)                                             
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)       1 (2%)                                             
      Pheochromocytoma Benign                          1 (2%)       5 (8%)       1 (2%)                                             
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                          3 (5%)       1 (2%)                                                          
   Parathyroid Gland                                  (58)         (60)         (59)         (57)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (60)         (60)                                   
      Pars Distalis, Adenoma                          38 (63%)     33 (55%)     31 (52%)     33 (55%)                               
      Pars Distalis, Adenoma, Multiple, Two                         1 (2%)                                                          
      Pars Distalis, Carcinoma                         1 (2%)       1 (2%)                                                          
      Pars Intermedia, Adenoma                         1 (2%)                    1 (2%)                                             
      Pars Intermedia, Carcinoma                                                 1 (2%)                                             
   Thyroid Gland                                      (60)         (60)         (60)         (59)                                   
      C-Cell, Adenoma                                  4 (7%)       4 (7%)       9 (15%)      5 (8%)                                
      C-Cell, Carcinoma                                                                       2 (3%)                                
      Follicular Cell, Adenoma                                                   1 (2%)       1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (60)         (60)         (60)         (59)                                   
      Adenoma                                                       1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma                                        1 (2%)       1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Ovary                                              (60)         (60)         (60)         (59)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
                                                             Page   3                                                               
NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
          Primary Site                                              1 (2%)                                                          
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Adenocarcinoma                                   1 (2%)                                 1 (2%)                                
      Adenoma                                          2 (3%)                                                                       
      Sarcoma                                                                                 1 (2%)                                
      Schwannoma Malignant                                          1 (2%)                                                          
      Endometrium, Polyp Stromal                      15 (25%)     16 (27%)      4 (7%)      10 (17%)                               
      Endometrium, Polyp Stromal, Multiple                          2 (3%)                                                          
      Endometrium, Sarcoma Stromal                                               1 (2%)       2 (3%)                                
      Endothelium, Polyp Stromal                                                              1 (2%)                                
   Vagina                                             (2)          (1)          (2)          (2)                                    
      Basal Cell Adenoma                                                         1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
   Lymph Node                                         (60)         (60)         (60)         (60)                                   
   Lymph Node, Mandibular                             (60)         (60)         (60)         (59)                                   
   Lymph Node, Mesenteric                             (60)         (60)         (60)         (59)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
   Thymus                                             (59)         (54)         (59)         (60)                                   
      Leiomyoma                                                                  1 (2%)                                             
      Epithelial Cell, Thymoma Benign                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (60)                                   
      Adenocarcinoma                                                1 (2%)       1 (2%)                                             
      Adenoma                                                                                 1 (2%)                                
      Fibroadenoma                                    10 (17%)     13 (22%)     10 (17%)     16 (27%)                               
      Fibroadenoma, Multiple, Two                      2 (3%)       4 (7%)       2 (3%)       1 (2%)                                
      Fibroadenoma, Multiple, Three                                                           1 (2%)                                
      Fibroma                                                                                 1 (2%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Subcutaneous Tissue, Fibroma                     1 (2%)                    2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma Malignant                                                      1 (2%)                                             
      Glioma Malignant                                 1 (2%)       1 (2%)                                                          
   Peripheral Nerve                                                (1)                       (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Adenocarcinoma                                   1 (2%)                                                                       
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                1 (2%)                                                                       
      Mediastinum, Adenocarcinoma, Metastatic,                                                                                      
           Uncertain Primary Site                                   1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (1)                       (1)          (1)                                    
   Zymbal's Gland                                     (1)          (3)                                                              
      Carcinoma                                        1 (100%)     2 (67%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Liposarcoma                                                                             1 (2%)                                
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
                                                             Page   5                                                               
NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Transitional Epithelium, Papilloma                            1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                             9 (15%)      6 (10%)     12 (20%)     12 (20%)                               
      Mesothelioma Benign                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            53          50          45          52                                       
     Total Primary Neoplasms                          101         100          88          98                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          45          39          47                                       
     Total Benign Neoplasms                            84          86          67          77                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              15          13          18          18                                       
     Total Malignant Neoplasms                         17          14          21          21                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2                       1                                       
     Total Metastatic Neoplasm                          8          13                       1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60           60                                     
  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           12           16           14                                     
    Natural Death                                      3            4            4            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           34           30           33                                     
  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (60)         (60)         (60)         (59)                                   
   Intestine Large, Colon                             (60)         (60)         (59)         (59)                                   
      Adenocarcinoma                                                1 (2%)                                                          
   Intestine Small, Ileum                             (59)         (60)         (60)         (59)                                   
   Intestine Small, Jejunum                           (59)         (60)         (60)         (58)                                   
   Liver                                              (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Intestine Large                   1 (2%)                                                          
      Hepatocellular Carcinoma                         1 (2%)                                                                       
      Hepatocellular Adenoma                           5 (8%)       4 (7%)       3 (5%)       3 (5%)                                
      Hepatocellular Adenoma, Multiple, Two            1 (2%)                                                                       
      Hepatocellular Adenoma, Multiple, Three                       1 (2%)                                                          
      Hepatocellular Adenoma, Multiple, Four                        1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (2%)                                             
   Mesentery                                          (17)         (16)         (13)         (11)                                   
      Adenocarcinoma, Metastatic, Intestine Large                   1 (6%)                                                          
      Lipoma                                                                                  1 (9%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                1 (8%)                                             
   Pancreas                                           (60)         (60)         (60)         (59)                                   
      Adenocarcinoma, Metastatic, Intestine Large                   1 (2%)                                                          
      Acinar Cell, Adenoma                             1 (2%)                    3 (5%)       1 (2%)                                
      Acinar Cell, Adenoma, Multiple                                2 (3%)                                                          
   Pharynx                                                                      (2)          (1)                                    
      Palate, Squamous Cell Carcinoma                                            2 (100%)                                           
      Palate, Squamous Cell Papilloma                                                         1 (100%)                              
   Salivary Glands                                    (60)         (60)         (60)         (59)                                   
      Adenoma                                                       1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Stomach, Forestomach                               (60)         (60)         (60)         (60)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (60)         (60)         (60)         (60)                                   
                                                             Page   8                                                               
NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Tongue                                             (60)         (60)         (59)         (60)                                   
      Squamous Cell Carcinoma                                                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)                    2 (3%)                                             
   Adrenal Gland, Medulla                             (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Malignant                       1 (2%)       2 (3%)       2 (3%)       2 (3%)                                
      Pheochromocytoma Complex                         1 (2%)       2 (3%)                                                          
      Pheochromocytoma Benign                         16 (27%)      8 (13%)     15 (25%)     13 (22%)                               
      Bilateral, Pheochromocytoma Benign               1 (2%)       4 (7%)       1 (2%)       1 (2%)                                
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                          2 (3%)                    1 (2%)       1 (2%)                                
      Carcinoma                                                                               1 (2%)                                
   Pituitary Gland                                    (59)         (60)         (59)         (58)                                   
      Pars Distalis, Adenoma                          11 (19%)      9 (15%)     10 (17%)      6 (10%)                               
   Thyroid Gland                                      (60)         (59)         (60)         (58)                                   
      C-Cell, Adenoma                                  9 (15%)      4 (7%)       7 (12%)      7 (12%)                               
      C-Cell, Carcinoma                                1 (2%)       1 (2%)       5 (8%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (1)          (2)          (1)                                    
      Cranial, Sarcoma, Metastatic, Uncertain                                                                                       
          Primary Site                                                                        1 (100%)                              
      Pelvic, Sarcoma, Metastatic, Uncertain                                                                                        
          Primary Site                                                           1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
   Preputial Gland                                    (60)         (60)         (60)         (60)                                   
      Adenoma                                          3 (5%)       2 (3%)       3 (5%)       2 (3%)                                
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Prostate                                           (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Intestine Large                   1 (2%)                                                          
   Seminal Vesicle                                    (60)         (60)         (60)         (60)                                   
                                                             Page   9                                                               
NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Adenocarcinoma, Metastatic, Intestine Large                   1 (2%)                                                          
   Testes                                             (60)         (60)         (60)         (60)                                   
      Bilateral, Interstitial Cell, Adenoma           54 (90%)     56 (93%)     55 (92%)     54 (90%)                               
      Interstitial Cell, Adenoma                       3 (5%)       2 (3%)       5 (8%)       5 (8%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (59)                                   
   Lymph Node                                         (60)         (60)         (60)         (59)                                   
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Zymbal's Gland                                                                      1 (2%)                                
      Mediastinal, Adenocarcinoma, Metastatic,                                                                                      
           Intestine Large                                          1 (2%)                                                          
      Renal, Adenocarcinoma, Metastatic, Intestine                                                                                  
          Large                                                     1 (2%)                                                          
   Lymph Node, Mandibular                             (60)         (59)         (60)         (58)                                   
      Carcinoma, Metastatic, Zymbal's Gland                                                   1 (2%)                                
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
   Lymph Node, Mesenteric                             (60)         (60)         (58)         (59)                                   
      Adenocarcinoma, Metastatic, Intestine Large                   1 (2%)                                                          
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Fibroma                                                       1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
   Thymus                                             (58)         (58)         (58)         (55)                                   
      Adenocarcinoma, Metastatic                                    1 (2%)                                                          
      Epithelial Cell, Thymoma Benign                  1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (58)         (58)         (60)                                   
      Fibroadenoma                                     4 (7%)       2 (3%)                    1 (2%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Basal Cell Carcinoma                                          1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Keratoacanthoma                                  5 (8%)                    1 (2%)                                             
      Schwannoma Malignant, Metastatic, Skeletal                                                                                    
          Muscle                                       1 (2%)                                                                       
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Subcutaneous Tissue, Fibroma                     4 (7%)       2 (3%)       3 (5%)       3 (5%)                                
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                    2 (3%)                                
      Subcutaneous Tissue, Leiomyoma                                             1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma, Metastatic,                                                                                     
           Uncertain Primary Site                                                             1 (2%)                                
                                                             Page  10                                                               
NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                                  1 (2%)                                                          
   Skeletal Muscle                                    (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Intestine Large                   1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site                                             1 (2%)                                
      Schwannoma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Glioma Malignant                                              1 (2%)                                                          
      Glioma NOS                                                    1 (2%)                                                          
      Oligodendroglioma Malignant                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Intestine Large                   1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     2 (3%)                    2 (3%)       1 (2%)                                
      Alveolar/Bronchiolar Adenoma, Multiple, Four                                            1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic,                                                                                          
          Uncertain Primary Site                                                              1 (2%)                                
      Mediastinum, Adenocarcinoma, Metastatic,                                                                                      
           Intestine Large                                          1 (2%)                                                          
   Nose                                               (60)         (60)         (60)         (60)                                   
      Mucosa, Squamous Cell Carcinoma                               1 (2%)       1 (2%)       1 (2%)                                
      Vomeronasal Organ, Carcinoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                       (1)          (2)                                    
      Carcinoma                                        1 (100%)                  1 (100%)     1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Adenocarcinoma, Metastatic, Intestine Large                   1 (2%)                                                          
      Lipoma                                                        1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic,                                                                                          
                                                             Page  11                                                               
NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
          Uncertain Primary Site                                                              1 (2%)                                
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
      Squamous Cell Papilloma                                       1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            16 (27%)     19 (32%)     18 (30%)     15 (25%)                               
      Mesothelioma Benign                              1 (2%)       2 (3%)       1 (2%)                                             
      Mesothelioma Malignant                                        1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05120-03  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           BENZYL ACETATE                                      Date: 09/15/94  
Route: DOSED FEED                                                                                                 Time: 13:39:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0%           0.3%         0.6%         1.2%                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            60          59          60          60                                       
     Total Primary Neoplasms                          148         140         144         129                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 60          59          60          60                                       
     Total Benign Neoplasms                           124         106         113         104                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          29          28          22                                       
     Total Malignant Neoplasms                         24          33          31          25                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           1           3                                       
     Total Metastatic Neoplasm                          1          16           3           9                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1           2                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  13                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.