National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3316

TDMS Study 05121-05 Pathology Tables

NTP Experiment-Test: 05121-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96
Route: GAVAGE                                                                                                     Time: 21:23:04




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  6533-68-2

       Lock Date:  05/14/92

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05121-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:23:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10                        10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13           10            6            7                                     
    Natural Death                                      3           15           16           16                                     
    Dosing Accident                                                 2            2            5                                     
    Accidently Killed                                              16                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           17           26           22                                     

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hepatocellular Adenoma                           1 (2%)                                                                       
   Tongue                                                                       (1)                                                 
      Squamous Cell Carcinoma                                                    1 (100%)                                           
   Tooth                                                                        (1)                                                 
      Gingiva, Squamous Cell Carcinoma                                           1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Schwannoma NOS                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                                                    2 (3%)       1 (2%)                                
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Benign                          1 (2%)                    1 (2%)       1 (2%)                                
      Bilateral, Pheochromocytoma Malignant                                                   1 (2%)                                
   Islets, Pancreatic                                 (60)         (60)         (59)         (60)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (60)         (60)         (60)         (60)                                   
      Pars Distalis, Adenoma                          21 (35%)     13 (22%)     15 (25%)     10 (17%)                               
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  2 (3%)       1 (2%)       2 (3%)       1 (2%)                                
      C-Cell, Carcinoma                                2 (3%)       1 (2%)                                                          

                                                             Page   2                                                               
NTP Experiment-Test: 05121-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:23:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Follicular Cell, Adenoma                         1 (2%)                                 3 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (59)         (60)         (58)         (60)                                   
      Adenoma                                          3 (5%)       2 (3%)       2 (3%)       1 (2%)                                
      Bilateral, Adenoma                                                         1 (2%)                                             
   Uterus                                             (60)         (60)         (60)         (60)                                   
      Adenoma                                                                                 1 (2%)                                
      Polyp Stromal                                    7 (12%)      1 (2%)       4 (7%)       4 (7%)                                
      Schwannoma NOS                                   1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (2%)                                
   Lymph Node                                         (2)          (2)          (2)                                                 
   Lymph Node, Mandibular                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Lymph Node, Mesenteric                             (60)         (59)         (60)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (2%)                                
   Thymus                                             (57)         (59)         (60)         (60)                                   
      Thymoma Malignant                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (60)         (60)         (58)                                   
      Adenoma                                                                    1 (2%)                                             
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
      Fibroadenoma                                    20 (33%)      8 (13%)     14 (23%)     13 (22%)                               
      Fibroadenoma, Multiple                           9 (15%)      2 (3%)       5 (8%)       3 (5%)                                
   Skin                                               (60)         (60)         (60)         (60)                                   
      Keratoacanthoma                                  1 (2%)       1 (2%)                                                          
      Sarcoma                                          1 (2%)                                                                       

                                                             Page   3                                                               
NTP Experiment-Test: 05121-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:23:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                                           (1)                                    
      Rhabdomyosarcoma                                                                        1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
   Peripheral Nerve                                   (5)          (6)          (5)          (2)                                    
   Spinal Cord                                        (2)          (4)          (5)          (2)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (3)          (2)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
   Urinary Bladder                                    (60)         (60)         (59)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Leukemia Mononuclear                            20 (33%)      6 (10%)     13 (22%)      4 (7%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   4                                                               
NTP Experiment-Test: 05121-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:23:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          23          40          33                                       
     Total Primary Neoplasms                           94          37          65          45                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 39          19          33          30                                       
     Total Benign Neoplasms                            68          28          47          39                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              23           9          16           6                                       
     Total Malignant Neoplasms                         24           9          18           6                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                                  1                                       
     Total Metastatic Neoplasm                                                              3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  2                                                                           
     Total Uncertain Neoplasms                          2                                                                           
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   5                                                               
NTP Experiment-Test: 05121-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:23:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           60           60           60                                     

  Scheduled Sacrifice                                 10           10           10           10                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23           30           20           17                                     
    Natural Death                                      5            4            7            4                                     
    Dosing Accident                                    2            2            1            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           14           22           28                                     

  Animals Examined Microscopically                    60           60           60           60                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)         (60)         (60)         (60)                                   
   Intestine Large, Colon                             (60)         (60)         (60)         (60)                                   
      Leiomyoma                                                                               1 (2%)                                
   Liver                                              (60)         (60)         (60)         (60)                                   
      Hepatocellular Carcinoma                         1 (2%)       1 (2%)                                                          
      Hepatocellular Adenoma                           1 (2%)       2 (3%)       2 (3%)       2 (3%)                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Mesentery                                          (7)          (15)         (24)         (15)                                   
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (7%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (4%)                                             
   Pancreas                                           (60)         (60)         (60)         (60)                                   
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Acinus, Adenoma                                  1 (2%)                                                                       
   Salivary Glands                                    (60)         (59)         (60)         (59)                                   
      Schwannoma Malignant                             1 (2%)                                                                       
   Tongue                                                          (1)                                                              
      Squamous Cell Papilloma                                       1 (100%)                                                        
   Tooth                                                                        (1)          (1)                                    
      Gingiva, Squamous Cell Carcinoma                                           1 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)         (60)                                   
      Schwannoma NOS                                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   6                                                               
NTP Experiment-Test: 05121-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:23:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (60)         (60)         (60)         (60)                                   
      Adenoma                                          1 (2%)                                                                       
   Adrenal Medulla                                    (60)         (60)         (60)         (60)                                   
      Pheochromocytoma Benign                          8 (13%)     11 (18%)      9 (15%)      9 (15%)                               
      Bilateral, Pheochromocytoma Benign               3 (5%)       2 (3%)       3 (5%)       1 (2%)                                
   Islets, Pancreatic                                 (60)         (60)         (60)         (60)                                   
      Adenoma                                          3 (5%)       2 (3%)       1 (2%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Parathyroid Gland                                  (55)         (55)         (55)         (59)                                   
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (59)         (58)         (60)         (60)                                   
      Pars Distalis, Adenoma                          19 (32%)     17 (29%)     14 (23%)     11 (18%)                               
      Pars Intermedia, Adenoma                                                                1 (2%)                                
   Thyroid Gland                                      (60)         (60)         (60)         (60)                                   
      Bilateral, C-Cell, Adenoma                                                 1 (2%)                                             
      C-Cell, Adenoma                                  1 (2%)       4 (7%)       2 (3%)       2 (3%)                                
      C-Cell, Carcinoma                                1 (2%)                    3 (5%)                                             
      Follicular Cell, Adenoma                         3 (5%)       2 (3%)       1 (2%)                                             
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)         (60)                                   
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Preputial Gland                                    (60)         (60)         (58)         (60)                                   
      Adenoma                                          3 (5%)       1 (2%)       4 (7%)       2 (3%)                                
      Carcinoma                                                     1 (2%)                                                          
   Testes                                             (60)         (60)         (60)         (60)                                   
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Bilateral, Interstitial Cell, Adenoma           43 (72%)     36 (60%)     41 (68%)     47 (78%)                               
      Interstitial Cell, Adenoma                       9 (15%)     14 (23%)     14 (23%)      6 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   7                                                               
NTP Experiment-Test: 05121-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:23:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (5)          (8)          (5)          (9)                                    
      Mediastinal, Osteosarcoma, Metastatic,                                                                                        
          Uncertain Primary Site                                                 1 (20%)                                            
   Lymph Node, Mandibular                             (60)         (59)         (60)         (58)                                   
   Lymph Node, Mesenteric                             (59)         (60)         (60)         (60)                                   
   Spleen                                             (60)         (60)         (60)         (60)                                   
      Fibroma                                                       1 (2%)                                                          
      Hemangiosarcoma                                                                         1 (2%)                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Thymus                                             (55)         (55)         (58)         (57)                                   
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Thymoma Malignant                                                                       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (55)         (57)         (57)         (56)                                   
      Fibroadenoma                                     3 (5%)       8 (14%)      3 (5%)       2 (4%)                                
      Fibroadenoma, Multiple                                                                  1 (2%)                                
   Skin                                               (60)         (60)         (60)         (59)                                   
      Basal Cell Adenoma                                                                      1 (2%)                                
      Fibroma                                          4 (7%)       3 (5%)       3 (5%)       2 (3%)                                
      Fibroma, Multiple                                1 (2%)                                 1 (2%)                                
      Fibrous Histiocytoma                                                       1 (2%)                                             
      Keratoacanthoma                                  3 (5%)       3 (5%)       3 (5%)       2 (3%)                                
      Keratoacanthoma, Multiple                        1 (2%)                                                                       
      Sarcoma                                          1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Squamous Cell Papilloma                                       3 (5%)                    2 (3%)                                
      Sebaceous Gland, Adenoma                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)         (60)                                   
      Osteosarcoma                                     1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (100%)                                                        
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (100%)                                           
      Sarcoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05121-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:23:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)         (60)                                   
      Astrocytoma NOS                                                            1 (2%)                                             
   Spinal Cord                                        (9)          (7)          (6)          (5)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)         (60)                                   
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                   1 (2%)       1 (2%)                                                          
      Squamous Cell Carcinoma, Metastatic, Tooth                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (1)          (1)          (1)                                    
   Harderian Gland                                    (1)                       (1)                                                 
      Adenoma                                          1 (100%)                                                                     
   Zymbal's Gland                                                  (2)          (2)          (2)                                    
      Carcinoma                                                     2 (100%)     2 (100%)     2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)         (60)                                   
      Fibroma                                                       1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)                                                                       
      Renal Tubule, Carcinoma                          1 (2%)                    1 (2%)                                             
   Urinary Bladder                                    (60)         (60)         (60)         (60)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(60)        *(60)        *(60)        *(60)                                   
      Leukemia Mononuclear                            34 (57%)     21 (35%)     26 (43%)     24 (40%)                               
      Mesothelioma NOS                                 1 (2%)       1 (2%)       4 (7%)       3 (5%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   9                                                               
NTP Experiment-Test: 05121-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                SCOPOLAMINE HYDROBROMIDE TRIHYDRATE                            Date: 04/03/96  
Route: GAVAGE                                                                                                     Time: 21:23:04  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     O MG/KG      1 MG/KG      5 MG/KG      25 MG/KG                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            58          57          59          57                                       
     Total Primary Neoplasms                          155         140         143         126                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 57          57          58          57                                       
     Total Benign Neoplasms                           110         112         102          93                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              39          27          30          29                                       
     Total Malignant Neoplasms                         44          27          35          30                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           1           1                                       
     Total Metastatic Neoplasm                          1           3          10           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1           1           6           3                                       
     Total Uncertain Neoplasms                          3           4          17           8                                       
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  10                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.