TDMS Study 05130-02 Pathology Tables
NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 Facility: Microbiological Associates Chemical CAS #: 10401-500 Lock Date: 10/29/91 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Note: Animals arranged according to CID number Page 1 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 7| 1| 7| 7| 7| 7| 3| 7| DAY ON TEST | 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 2| 6| 4| | 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 8| 4| 4| 4| 4| 4| 4| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + A + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + A + + A + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Hemangiosarcoma | X | Hepatocellular Carcinoma | X X| Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | Sarcoma Stromal, Metastatic, Uterus | | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + M + M + + M M M M + + M + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + M + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 2 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 7| 1| 7| 7| 7| 7| 3| 7| DAY ON TEST | 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 2| 6| 4| | 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 8| 4| 4| 4| 4| 4| 4| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Clitoral Gland | + | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Lymphoma Malignant Lymphocytic | X | Teratoma Benign | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | X | Sarcoma Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Lymph Node | + + + + + + | Deep Cervical, Lymphoma Malignant | | Lymphocytic | X | Iliac, Sarcoma Stromal, Metastatic, | | Uterus | | Lumbar, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Pancreatic, Lymphoma Malignant | | Lymphocytic | X | Pancreatic, Lymphoma Malignant Mixed | X | Renal, Lymphoma Malignant Lymphocytic| X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + + + M + +| Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 3 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 0| 7| 7| 1| 7| 7| 7| 7| 3| 7| DAY ON TEST | 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 8| 4| 4| 8| 4| 4| 4| 2| 6| 4| | 8| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 8| 4| 4| 4| 4| 4| 4| 8| 8| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X| Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | Sarcoma Stromal, Metastatic, Uterus | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | +| __________________________________________________________________________| Harderian Gland | +| Adenoma | X| __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + M + + M + + M M + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 4 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 1| 4| 4| 4| 0| 4| 4| 4| 4| 4| 2| 4| 1| 4| 4| 4| | 4| 4| 4| 4| 8| 4| 3| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 4| 7| 4| 3| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + M + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + A + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Hemangiosarcoma | | Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | Sarcoma Stromal, Metastatic, Uterus | X | __________________________________________________________________________| Mesentery | + + + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + M + + + M + + + M + + + M + M + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 5 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 1| 4| 4| 4| 0| 4| 4| 4| 4| 4| 2| 4| 1| 4| 4| 4| | 4| 4| 4| 4| 8| 4| 3| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 4| 7| 4| 3| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + + + A + + + + + + + + + M + + +| Cystadenoma | X X | Lymphoma Malignant Lymphocytic | | Teratoma Benign | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Leiomyoma | | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Lymph Node | + + + | Deep Cervical, Lymphoma Malignant | | Lymphocytic | | Iliac, Sarcoma Stromal, Metastatic, | | Uterus | X | Lumbar, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Pancreatic, Lymphoma Malignant | | Lymphocytic | | Pancreatic, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Lymphocytic| | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + A + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Spleen | + + + + + + + + + + A + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + M + + + M + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | _____________________________________________________________________________________________________________________| Page 6 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 6| 7| 0| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 1| 4| 4| 4| 0| 4| 4| 4| 4| 4| 2| 4| 1| 4| 4| 4| | 4| 4| 4| 4| 8| 4| 3| 4| 4| 7| 4| 4| 4| 1| 4| 4| 4| 4| 4| 7| 4| 3| 4| 4| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | Sarcoma Stromal, Metastatic, Uterus | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | __________________________________________________________________________| Zymbal's Gland | + + + + M + + + M M + + + M + + + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + A + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 7 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 49 | __________________________________________________________________________|____________| Gallbladder | | 47 | __________________________________________________________________________|____________| Intestine Large, Colon | | 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 47 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 47 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 48 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Liver | | 49 | Hemangioma | | 1 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | | 5 | Hepatocellular Adenoma | | 6 | Hepatocellular Adenoma, Multiple | | 1 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Sarcoma Stromal, Metastatic, Uterus | | 1 | __________________________________________________________________________|____________| Mesentery | | 6 | __________________________________________________________________________|____________| Pancreas | | 49 | __________________________________________________________________________|____________| Salivary Glands | | 49 | __________________________________________________________________________|____________| Stomach, Forestomach | | 49 | __________________________________________________________________________|____________| Stomach, Glandular | | 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 49 | __________________________________________________________________________|____________| Adrenal Medulla | | 49 | __________________________________________________________________________|____________| Islets, Pancreatic | | 49 | __________________________________________________________________________|____________| Parathyroid Gland | | 33 | __________________________________________________________________________|____________| Pituitary Gland | | 48 | Pars Distalis, Adenoma | | 2 | __________________________________________________________________________|____________| Thyroid Gland | | 49 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 8 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | __________________________________________________________________________|____________| Ovary | | 47 | Cystadenoma | | 2 | Lymphoma Malignant Lymphocytic | | 1 | Teratoma Benign | | 1 | __________________________________________________________________________|____________| Uterus | | 49 | Leiomyoma | | 1 | Sarcoma Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 49 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Lymph Node | | 9 | Deep Cervical, Lymphoma Malignant | | | Lymphocytic | | 1 | Iliac, Sarcoma Stromal, Metastatic, | | | Uterus | | 1 | Lumbar, Lymphoma Malignant | | | Lymphocytic | | 1 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Pancreatic, Lymphoma Malignant | | | Lymphocytic | | 1 | Pancreatic, Lymphoma Malignant Mixed | | 1 | Renal, Lymphoma Malignant Lymphocytic| | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | | 49 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 46 | Lymphoma Malignant Lymphocytic | | 3 | __________________________________________________________________________|____________| Spleen | | 48 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 9 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Thymus | | 46 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 49 | Adenoma | | 1 | __________________________________________________________________________|____________| Skin | | 49 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 49 | Alveolar/Bronchiolar Adenoma | | 5 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Sarcoma Stromal, Metastatic, Uterus | | 1 | __________________________________________________________________________|____________| Nose | | 49 | __________________________________________________________________________|____________| Trachea | | 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 2 | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Harderian Gland | | 3 | Adenoma | | 3 | __________________________________________________________________________|____________| Zymbal's Gland | | 38 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 49 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 10 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | T | ANIMAL ID | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ URINARY SYSTEM - cont | | | | | | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Urinary Bladder | | 48 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | | 49 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 4 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 11 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + M + + + + + + + + + + M +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X X | Hemangiosarcoma, Metastatic, Skin | | Hepatocellular Carcinoma | X X| Hepatocellular Adenoma | X X X| Hepatocellular Adenoma, Multiple | X X X | Hepatocholangiocarcinoma | X | Histiocytic Sarcoma | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Mesentery | + + + | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | _____________________________________________________________________________________________________________________| Page 12 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + M +| Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + M +| Pheochromocytoma Benign | | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + + M + + + M + M + + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | Follicular Cell, Carcinoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + | Carcinoma, Metastatic, Thyroid Gland | X | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | X | Granulosa Cell Tumor Benign | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Bone | | Marrow | | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | X X | Sarcoma Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | | Vertebral, Hemangiosarcoma | | __________________________________________________________________________| Lymph Node | + + + | _____________________________________________________________________________________________________________________| Page 13 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Axillary, Lymphoma Malignant | | Lymphocytic | X | Bronchial, Hepatocellular Carcinoma, | | Metastatic, Liver | | Bronchial, Lymphoma Malignant | | Lymphocytic | X | Bronchial, Osteosarcoma, Metastatic, | | Bone | | Deep Cervical, Lymphoma Malignant | | Lymphocytic | X | Inguinal, Lymphoma Malignant | | Lymphocytic | X | Lumbar, Hepatocholangiocarcinoma, | | Metastatic, Liver | X | Lumbar, Lymphoma Malignant | | Lymphocytic | X | Lumbar, Lymphoma Malignant Mixed | | Mediastinal, | | Hepatocholangiocarcinoma, | | Metastatic, Liver | X | Mediastinal, Lymphoma Malignant | | Lymphocytic | X X | Mediastinal, Lymphoma Malignant Mixed| | Pancreatic, Lymphoma Malignant | | Lymphocytic | | Pancreatic, Lymphoma Malignant Mixed | | Renal, Hepatocholangiocarcinoma, | | Metastatic, Liver | X | Renal, Lymphoma Malignant Lymphocytic| X | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + M + + + + M + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 14 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Dorsal, Osteosarcoma | | Vertebra, Hemangiosarcoma, Extension | | __________________________________________________________________________| Skeletal Muscle | + | Back, Hemangiosarcoma, Extension | | Diaphragm, Hepatocholangiocarcinoma, | | Metastatic, Liver | X | Diaphragm, Lymphoma Malignant | | Lymphocytic | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | + | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Alveolar/Bronchiolar Adenoma, | | Multiple | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Hepatocholangiocarcinoma, Metastatic,| | Liver | X | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | Osteosarcoma, Metastatic, Bone | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Zymbal's Gland | + I + + M + + + + M M + M M + + + + + + + + + M +| _____________________________________________________________________________________________________________________| Page 15 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 5| 7| DAY ON TEST | 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 9| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 5| 4| | 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 4| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | Bilateral, Osteosarcoma, Metastatic, | | Bone | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 16 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4| | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M + + + + + + + + + + + + + + + + + + M + + + M +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + A + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hemangiosarcoma, Metastatic, Skin | X | Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X | Hepatocholangiocarcinoma | | Histiocytic Sarcoma | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | X | Osteosarcoma, Metastatic, Bone | X | __________________________________________________________________________| Mesentery | + + | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | _____________________________________________________________________________________________________________________| Page 17 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4| | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + M + M M M M + M + + + + M + M M + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | Follicular Cell, Carcinoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Carcinoma, Metastatic, Thyroid Gland | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Cystadenoma | | Granulosa Cell Tumor Benign | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Bone | | Marrow | X | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Vertebral, Hemangiosarcoma | X | __________________________________________________________________________| Lymph Node | + + + + + + + | _____________________________________________________________________________________________________________________| Page 18 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4| | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Axillary, Lymphoma Malignant | | Lymphocytic | | Bronchial, Hepatocellular Carcinoma, | | Metastatic, Liver | X | Bronchial, Lymphoma Malignant | | Lymphocytic | X | Bronchial, Osteosarcoma, Metastatic, | | Bone | X | Deep Cervical, Lymphoma Malignant | | Lymphocytic | | Inguinal, Lymphoma Malignant | | Lymphocytic | | Lumbar, Hepatocholangiocarcinoma, | | Metastatic, Liver | | Lumbar, Lymphoma Malignant | | Lymphocytic | | Lumbar, Lymphoma Malignant Mixed | X | Mediastinal, | | Hepatocholangiocarcinoma, | | Metastatic, Liver | | Mediastinal, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant Mixed| X | Pancreatic, Lymphoma Malignant | | Lymphocytic | X | Pancreatic, Lymphoma Malignant Mixed | X X | Renal, Hepatocholangiocarcinoma, | | Metastatic, Liver | | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + M + + + + + + + + + + + + + + M + + + + +| Hepatocholangiocarcinoma, Metastatic,| | Liver | | Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 19 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4| | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + M + +| Lymphoma Malignant Lymphocytic | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| Dorsal, Osteosarcoma | X | Vertebra, Hemangiosarcoma, Extension | X | __________________________________________________________________________| Skeletal Muscle | + + | Back, Hemangiosarcoma, Extension | X | Diaphragm, Hepatocholangiocarcinoma, | | Metastatic, Liver | | Diaphragm, Lymphoma Malignant | | Lymphocytic | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spinal Cord | | _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Hepatocholangiocarcinoma, Metastatic,| | Liver | | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X | Osteosarcoma, Metastatic, Bone | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Zymbal's Gland | + + + + M + + M + + + + + M + + + + + M M + + + +| _____________________________________________________________________________________________________________________| Page 20 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7| 7| 6| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7| 4| 4| 4| 4| 4| 9| 4| 4| | 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 8| 9| 9| 3| 3| 8| 3| 3| 3| 3| 4| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Bilateral, Osteosarcoma, Metastatic, | | Bone | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | X X X X X | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 21 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | __________________________________________________________________________|____________| Gallbladder | | 45 | __________________________________________________________________________|____________| Intestine Large, Colon | | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 50 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 50 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 49 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 50 | Lymphoma Malignant Histiocytic | | 1 | __________________________________________________________________________|____________| Liver | | 50 | Hemangiosarcoma | | 3 | Hemangiosarcoma, Metastatic, Skin | | 1 | Hepatocellular Carcinoma | | 5 | Hepatocellular Adenoma | | 8 | Hepatocellular Adenoma, Multiple | | 4 | Hepatocholangiocarcinoma | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 5 | Lymphoma Malignant Mixed | | 1 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Mesentery | | 5 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Pancreas | | 50 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Salivary Glands | | 50 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 22 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - cont | | | | | | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | | 50 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 49 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Adrenal Medulla | | 49 | Pheochromocytoma Benign | | 1 | __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________|____________| Parathyroid Gland | | 34 | __________________________________________________________________________|____________| Pituitary Gland | | 50 | Pars Distalis, Adenoma | | 6 | __________________________________________________________________________|____________| Thyroid Gland | | 50 | Follicular Cell, Adenoma | | 1 | Follicular Cell, Carcinoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 2 | Carcinoma, Metastatic, Thyroid Gland | | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | | 50 | Cystadenoma | | 1 | Granulosa Cell Tumor Benign | | 1 | Lymphoma Malignant Lymphocytic | | 3 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Uterus | | 50 | Hemangiosarcoma, Metastatic, Bone | | | Marrow | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 23 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 3 | Sarcoma Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | Vertebral, Hemangiosarcoma | | 1 | __________________________________________________________________________|____________| Lymph Node | | 10 | Axillary, Lymphoma Malignant | | | Lymphocytic | | 1 | Bronchial, Hepatocellular Carcinoma, | | | Metastatic, Liver | | 1 | Bronchial, Lymphoma Malignant | | | Lymphocytic | | 2 | Bronchial, Osteosarcoma, Metastatic, | | | Bone | | 1 | Deep Cervical, Lymphoma Malignant | | | Lymphocytic | | 1 | Inguinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Lumbar, Hepatocholangiocarcinoma, | | | Metastatic, Liver | | 1 | Lumbar, Lymphoma Malignant | | | Lymphocytic | | 1 | Lumbar, Lymphoma Malignant Mixed | | 1 | Mediastinal, | | | Hepatocholangiocarcinoma, | | | Metastatic, Liver | | 1 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 3 | Mediastinal, Lymphoma Malignant Mixed| | 1 | Pancreatic, Lymphoma Malignant | | | Lymphocytic | | 1 | Pancreatic, Lymphoma Malignant Mixed | | 2 | Renal, Hepatocholangiocarcinoma, | | | Metastatic, Liver | | 1 | Renal, Lymphoma Malignant Lymphocytic| | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 24 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Renal, Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | | 48 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 48 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 4 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Spleen | | 50 | Hemangiosarcoma | | 1 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 4 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Thymus | | 48 | Lymphoma Malignant Lymphocytic | | 4 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 49 | __________________________________________________________________________|____________| Skin | | 50 | Subcutaneous Tissue, Hemangiosarcoma | | 2 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 50 | Dorsal, Osteosarcoma | | 1 | Vertebra, Hemangiosarcoma, Extension | | 1 | __________________________________________________________________________|____________| Skeletal Muscle | | 3 | Back, Hemangiosarcoma, Extension | | 1 | Diaphragm, Hepatocholangiocarcinoma, | | | Metastatic, Liver | | 1 | Diaphragm, Lymphoma Malignant | | | Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | __________________________________________________________________________|____________| Spinal Cord | | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 25 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Alveolar/Bronchiolar Adenoma | | 5 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Hepatocholangiocarcinoma, Metastatic,| | | Liver | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 4 | Lymphoma Malignant Mixed | | 1 | Osteosarcoma, Metastatic, Bone | | 1 | __________________________________________________________________________|____________| Nose | | 50 | __________________________________________________________________________|____________| Trachea | | 50 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 1 | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 38 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 1 | Bilateral, Osteosarcoma, Metastatic, | | | Bone | | 1 | __________________________________________________________________________|____________| Urinary Bladder | | 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | | 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Histiocytic | | 2 | Lymphoma Malignant Lymphocytic | | 7 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 26 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + I + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + A + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + A + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | Osteosarcoma, Metastatic, Nose | X | __________________________________________________________________________| Mesentery | + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + A + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + A + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + A + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + A + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + A + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + A + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + M + M M + M + + A + + + + + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 27 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + A + + + + + + + + + + + +| Granulosa Cell Tumor Benign | | Hemangioma | | Lymphoma Malignant Lymphocytic | | Teratoma Benign | | Thecoma Benign | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Polyp Stromal | X | Sarcoma Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + + + | Lymphoma Malignant Lymphocytic | X | Bronchial, Lymphoma Malignant | | Lymphocytic | | Lumbar, Lymphoma Malignant | | Lymphocytic | X | Lumbar, Lymphoma Malignant Mixed | X X | Mediastinal, Lymphoma Malignant | | Lymphocytic | X X | Mediastinal, Lymphoma Malignant Mixed| X X | Pancreatic, Lymphoma Malignant | | Lymphocytic | X | Pancreatic, Lymphoma Malignant Mixed | X | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + A + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + M + + + + + + + + I + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + A + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 28 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 3| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Subcutaneous Tissue, Sarcoma | X | Subcutaneous Tissue, Schwannoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | Lymphoma Malignant Undifferentiated | | Cell Type | X | Osteosarcoma, Metastatic, Nose | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | __________________________________________________________________________| Zymbal's Gland | + M + + + + + + + + + M + + M M + + + + M + + M M| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + A + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | X X | Lymphoma Malignant Undifferentiated | | Cell Type | X | _____________________________________________________________________________________________________________________| Page 29 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | M M + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X X X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | Osteosarcoma, Metastatic, Nose | | __________________________________________________________________________| Mesentery | + + | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + +| Pheochromocytoma Benign | X | __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + + + + + M + + + + + M + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Pars Distalis, Adenoma | X X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| Page 30 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Granulosa Cell Tumor Benign | X X | Hemangioma | X | Lymphoma Malignant Lymphocytic | X X | Teratoma Benign | X | Thecoma Benign | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | Polyp Stromal | | Sarcoma Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + | Lymphoma Malignant Lymphocytic | | Bronchial, Lymphoma Malignant | | Lymphocytic | X | Lumbar, Lymphoma Malignant | | Lymphocytic | | Lumbar, Lymphoma Malignant Mixed | | Mediastinal, Lymphoma Malignant | | Lymphocytic | X X X | Mediastinal, Lymphoma Malignant Mixed| | Pancreatic, Lymphoma Malignant | | Lymphocytic | X | Pancreatic, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Lymphocytic| X X | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 31 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 4| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| | 2| 2| 4| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Subcutaneous Tissue, Sarcoma | | Subcutaneous Tissue, Schwannoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | Osteosarcoma, Metastatic, Nose | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| Osteosarcoma | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | __________________________________________________________________________| Zymbal's Gland | M + M + + M M + + + + + + + + M + + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X X | Lymphoma Malignant Mixed | | Lymphoma Malignant Undifferentiated | | Cell Type | | _____________________________________________________________________________________________________________________| Page 32 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 49 | __________________________________________________________________________|____________| Gallbladder | | 46 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | | 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 48 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 48 | Carcinoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 48 | __________________________________________________________________________|____________| Liver | | 49 | Hepatocellular Carcinoma | | 6 | Hepatocellular Adenoma | | 9 | Hepatocellular Adenoma, Multiple | | 8 | Lymphoma Malignant Lymphocytic | | 3 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Osteosarcoma, Metastatic, Nose | | 1 | __________________________________________________________________________|____________| Mesentery | | 3 | __________________________________________________________________________|____________| Pancreas | | 48 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Salivary Glands | | 49 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | | 48 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | | 48 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 48 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Adrenal Medulla | | 48 | Pheochromocytoma Benign | | 2 | __________________________________________________________________________|____________| Islets, Pancreatic | | 48 | __________________________________________________________________________|____________| Parathyroid Gland | | 40 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 33 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | | 49 | Pars Distalis, Adenoma | | 2 | __________________________________________________________________________|____________| Thyroid Gland | | 49 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ovary | | 48 | Granulosa Cell Tumor Benign | | 2 | Hemangioma | | 1 | Lymphoma Malignant Lymphocytic | | 2 | Teratoma Benign | | 1 | Thecoma Benign | | 1 | __________________________________________________________________________|____________| Uterus | | 49 | Lymphoma Malignant Lymphocytic | | 2 | Polyp Stromal | | 1 | Sarcoma Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 49 | __________________________________________________________________________|____________| Lymph Node | | 8 | Lymphoma Malignant Lymphocytic | | 1 | Bronchial, Lymphoma Malignant | | | Lymphocytic | | 1 | Lumbar, Lymphoma Malignant | | | Lymphocytic | | 1 | Lumbar, Lymphoma Malignant Mixed | | 2 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 5 | Mediastinal, Lymphoma Malignant Mixed| | 2 | Pancreatic, Lymphoma Malignant | | | Lymphocytic | | 2 | Pancreatic, Lymphoma Malignant Mixed | | 1 | Renal, Lymphoma Malignant Lymphocytic| | 2 | Renal, Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | | 48 | Lymphoma Malignant Lymphocytic | | 3 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 34 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 47 | Lymphoma Malignant Lymphocytic | | 3 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Spleen | | 49 | Lymphoma Malignant Lymphocytic | | 5 | Lymphoma Malignant Mixed | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________|____________| Thymus | | 48 | Lymphoma Malignant Lymphocytic | | 2 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 49 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Skin | | 49 | Lymphoma Malignant Lymphocytic | | 1 | Subcutaneous Tissue, Sarcoma | | 1 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 49 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 49 | Alveolar/Bronchiolar Adenoma | | 4 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 2 | Lymphoma Malignant Lymphocytic | | 3 | Lymphoma Malignant Mixed | | 1 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | Osteosarcoma, Metastatic, Nose | | 1 | __________________________________________________________________________|____________| Nose | | 49 | Osteosarcoma | | 1 | __________________________________________________________________________|____________| Trachea | | 49 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 35 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 2 | Adenoma | | 2 | __________________________________________________________________________|____________| Zymbal's Gland | | 37 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 49 | Lymphoma Malignant Lymphocytic | | 3 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Urinary Bladder | | 48 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | | 49 | Lymphoma Malignant Lymphocytic | | 5 | Lymphoma Malignant Mixed | | 2 | Lymphoma Malignant Undifferentiated | | | Cell Type | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 36 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 0| 4| 4| 4| 4| 4| | 9| 9| 9| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 0| 2| 1| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + M + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + + A + + + + + + M + + + + + + + A + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + A + + + + + + + + + + + + + + A + + +| Lymphoma Malignant Mixed | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + A + + + + + + + + + + + + + + A + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + A + + + + + + + + + + A + + + A + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + A + + + + + + + + + + + + + + A + + +| Carcinoma | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatoblastoma | X | Hepatocellular Carcinoma | X X X X X| Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Mesentery | + + + | Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + + + + + + + + M + + + M M + + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + M + + + + + + + M + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 37 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 0| 4| 4| 4| 4| 4| | 9| 9| 9| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 0| 2| 1| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | __________________________________________________________________________| Tissue NOS | + | Sarcoma, Metastatic, Skeletal Muscle | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| Choriocarcinoma | | Cystadenoma | X | Hemangioma | | Lymphoma Malignant Lymphocytic | X X | Teratoma Benign | X | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| Deciduoma Benign | | Hemangioma | X | Hemangiosarcoma | X | Leiomyoma | X | Polyp Stromal | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node | + + + | Lymphoma Malignant Histiocytic | | Iliac, Lymphoma Malignant Histiocytic| | Lumbar, Lymphoma Malignant | | Lymphocytic | X X | Lumbar, Lymphoma Malignant Mixed | | Mediastinal, Lymphoma Malignant | | Lymphocytic | X X | Pancreatic, Lymphoma Malignant | | Lymphocytic | X | Pancreatic, Lymphoma Malignant Mixed | | Renal, Lymphoma Malignant Histiocytic| | Renal, Lymphoma Malignant Lymphocytic| X X | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + M +| Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X X | _____________________________________________________________________________________________________________________| Page 38 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 7| DAY ON TEST | 3| 3| 3| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 0| 4| 4| 4| 4| 4| | 9| 9| 9| 2| 2| 2| 7| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 4| 2| 0| 2| 1| 2| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant Mixed | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + M + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | X | Subcutaneous Tissue, Schwannoma | | Malignant | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Back, Sarcoma | X | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + M + + + + M M M + + + M + + M + + + + + + + M M| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | | Lymphoma Malignant Lymphocytic | X X | Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| Page 39 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 5| 7| 7| DAY ON TEST | 2| 4| 4| 4| 4| 8| 4| 4| 4| 0| 4| 4| 4| 4| 1| 4| 3| 2| 9| 4| 4| 4| 3| 4| 4| | 7| 2| 2| 2| 2| 9| 2| 2| 2| 8| 2| 2| 2| 2| 5| 2| 8| 1| 4| 2| 2| 2| 9| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + M + + + + + M + + + + + + M + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | A + + + + + + + + A + + + + + + + + + + + + + +| Lymphoma Malignant Mixed | X | __________________________________________________________________________| Intestine Small, Duodenum | A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | A + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | A + + + + + + + + A + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatoblastoma | | Hepatocellular Carcinoma | X X X X X X X| Hepatocellular Adenoma | X | Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X X X| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Mesentery | + + | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + M + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + M + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + M + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + M + M + M + + + + + + + + + M + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + M + + + + + + M + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | _____________________________________________________________________________________________________________________| Page 40 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 5| 7| 7| DAY ON TEST | 2| 4| 4| 4| 4| 8| 4| 4| 4| 0| 4| 4| 4| 4| 1| 4| 3| 2| 9| 4| 4| 4| 3| 4| 4| | 7| 2| 2| 2| 2| 9| 2| 2| 2| 8| 2| 2| 2| 2| 5| 2| 8| 1| 4| 2| 2| 2| 9| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | __________________________________________________________________________| Tissue NOS | | Sarcoma, Metastatic, Skeletal Muscle | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Clitoral Gland | + | __________________________________________________________________________| Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| Choriocarcinoma | X | Cystadenoma | | Hemangioma | X | Lymphoma Malignant Lymphocytic | | Teratoma Benign | | __________________________________________________________________________| Uterus | + + + + + + + + + + + + + + + + + + + + + + + +| Deciduoma Benign | X | Hemangioma | | Hemangiosarcoma | | Leiomyoma | | Polyp Stromal | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node | + + + + | Lymphoma Malignant Histiocytic | X | Iliac, Lymphoma Malignant Histiocytic| X | Lumbar, Lymphoma Malignant | | Lymphocytic | | Lumbar, Lymphoma Malignant Mixed | X X | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Pancreatic, Lymphoma Malignant | | Lymphocytic | | Pancreatic, Lymphoma Malignant Mixed | X | Renal, Lymphoma Malignant Histiocytic| X | Renal, Lymphoma Malignant Lymphocytic| | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + M + + + + + + M + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + M + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| Page 41 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 4| 7| 7| 7| 7| 6| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 0| 7| 6| 7| 7| 7| 5| 7| 7| DAY ON TEST | 2| 4| 4| 4| 4| 8| 4| 4| 4| 0| 4| 4| 4| 4| 1| 4| 3| 2| 9| 4| 4| 4| 3| 4| 4| | 7| 2| 2| 2| 2| 9| 2| 2| 2| 8| 2| 2| 2| 2| 5| 2| 8| 1| 4| 2| 2| 2| 9| 2| 2| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | Lymphoma Malignant Mixed | X X | __________________________________________________________________________| Thymus | + + M + + + + + + + + + + + + + + M + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Carcinoma | | Subcutaneous Tissue, Schwannoma | | Malignant | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Back, Sarcoma | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + + M + + + + + + M + + + M + M + + M M +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Histiocytic | X | Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 42 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 48 | __________________________________________________________________________|____________| Gallbladder | | 42 | __________________________________________________________________________|____________| Intestine Large, Colon | | 49 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 45 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 46 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 45 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 45 | Carcinoma | | 1 | __________________________________________________________________________|____________| Liver | | 49 | Hemangiosarcoma | | 1 | Hepatoblastoma | | 1 | Hepatocellular Carcinoma | | 12 | Hepatocellular Adenoma | | 6 | Hepatocellular Adenoma, Multiple | | 35 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Mesentery | | 5 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Pancreas | | 49 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Salivary Glands | | 48 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Stomach, Forestomach | | 49 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | | 49 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 49 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 48 | Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | | 47 | __________________________________________________________________________|____________| Islets, Pancreatic | | 49 | __________________________________________________________________________|____________| Parathyroid Gland | | 40 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 43 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Pituitary Gland | | 45 | __________________________________________________________________________|____________| Thyroid Gland | | 49 | Follicular Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Sarcoma, Metastatic, Skeletal Muscle | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Clitoral Gland | | 1 | __________________________________________________________________________|____________| Ovary | | 49 | Choriocarcinoma | | 1 | Cystadenoma | | 1 | Hemangioma | | 1 | Lymphoma Malignant Lymphocytic | | 2 | Teratoma Benign | | 1 | __________________________________________________________________________|____________| Uterus | | 49 | Deciduoma Benign | | 1 | Hemangioma | | 1 | Hemangiosarcoma | | 1 | Leiomyoma | | 1 | Polyp Stromal | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 49 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node | | 7 | Lymphoma Malignant Histiocytic | | 1 | Iliac, Lymphoma Malignant Histiocytic| | 1 | Lumbar, Lymphoma Malignant | | | Lymphocytic | | 2 | Lumbar, Lymphoma Malignant Mixed | | 2 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 2 | Pancreatic, Lymphoma Malignant | | | Lymphocytic | | 1 | Pancreatic, Lymphoma Malignant Mixed | | 1 | Renal, Lymphoma Malignant Histiocytic| | 1 | Renal, Lymphoma Malignant Lymphocytic| | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 44 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Renal, Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | | 47 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 46 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Spleen | | 49 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________|____________| Thymus | | 46 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 48 | __________________________________________________________________________|____________| Skin | | 49 | Squamous Cell Carcinoma | | 1 | Subcutaneous Tissue, Schwannoma | | | Malignant | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 49 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Back, Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 49 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 49 | Alveolar/Bronchiolar Adenoma | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Nose | | 49 | __________________________________________________________________________|____________| Trachea | | 49 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 45 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE FEMALE | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGH FEM | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 32 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 49 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Urinary Bladder | | 49 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | | 49 | Lymphoma Malignant Histiocytic | | 1 | Lymphoma Malignant Lymphocytic | | 2 | Lymphoma Malignant Mixed | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 46 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 1| 1| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 3| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + M + + + + M + + + + + + + + M M + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + A + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + A + + + + + + + + + + + + + + + +| Carcinoma | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + A + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X X| Hepatocellular Adenoma | X X X X X X| Hepatocellular Adenoma, Multiple | X X X | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | Mast Cell Tumor Malignant, | | Metastatic, Spleen | | __________________________________________________________________________| Mesentery | + + + | __________________________________________________________________________| Pancreas | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + M + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + A + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + M M + M + + + + + + + M M + + + + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 47 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 1| 1| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 3| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Histiocytic Sarcoma | X | Sarcoma | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Mast Cell Tumor Malignant, | | Metastatic, Spleen | | __________________________________________________________________________| Lymph Node | + | Axillary, Lymphoma Malignant | | Lymphocytic | | Bronchial, Lymphoma Malignant | | Lymphocytic | | Iliac, Lymphoma Malignant Lymphocytic| | Inguinal, Lymphoma Malignant | | Lymphocytic | | Lumbar, Lymphoma Malignant | | Lymphocytic | | Pancreatic, Lymphoma Malignant | | Lymphocytic | | Renal, Lymphoma Malignant Lymphocytic| | __________________________________________________________________________| Lymph Node, Mandibular | + + + + M + M + + + + + + + + + + + + + + + + M +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + A + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Spleen | + + + + + + + + A + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Mast Cell Tumor Malignant | | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + M + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M + M M M M M M M M M M M M M I M M I I M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Lipoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 48 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 1| 1| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| 9| 3| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Pinna, Sarcoma | X | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + M + + M + + + + + + + + + M M| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| Page 49 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + M + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + A + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + A + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | Mast Cell Tumor Malignant, | | Metastatic, Spleen | X | __________________________________________________________________________| Mesentery | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + M + + + + + + + + M + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 50 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENITAL SYSTEM - cont | | | | Histiocytic Sarcoma | | Sarcoma | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Mast Cell Tumor Malignant, | | Metastatic, Spleen | X | __________________________________________________________________________| Lymph Node | + + + | Axillary, Lymphoma Malignant | | Lymphocytic | X | Bronchial, Lymphoma Malignant | | Lymphocytic | X X | Iliac, Lymphoma Malignant Lymphocytic| X | Inguinal, Lymphoma Malignant | | Lymphocytic | X | Lumbar, Lymphoma Malignant | | Lymphocytic | X | Pancreatic, Lymphoma Malignant | | Lymphocytic | X X | Renal, Lymphoma Malignant Lymphocytic| X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | Mast Cell Tumor Malignant | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Lipoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 51 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 3| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 8| 3| 3| 3| 3| 3| 3| 3| 3| | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 8| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| CONTROL | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Ear | + | Pinna, Sarcoma | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | Adenoma | X | __________________________________________________________________________| Zymbal's Gland | + + M + + + + + + + + + M + + M + + M + + + M +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X X | _____________________________________________________________________________________________________________________| Page 52 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 49 | __________________________________________________________________________|____________| Gallbladder | | 45 | __________________________________________________________________________|____________| Intestine Large, Colon | | 48 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 48 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 48 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 49 | Carcinoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 49 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Liver | | 50 | Hepatocellular Carcinoma | | 7 | Hepatocellular Adenoma | | 12 | Hepatocellular Adenoma, Multiple | | 4 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | Mast Cell Tumor Malignant, | | | Metastatic, Spleen | | 1 | __________________________________________________________________________|____________| Mesentery | | 3 | __________________________________________________________________________|____________| Pancreas | | 49 | __________________________________________________________________________|____________| Salivary Glands | | 49 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | __________________________________________________________________________|____________| Stomach, Glandular | | 50 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 50 | __________________________________________________________________________|____________| Adrenal Medulla | | 50 | __________________________________________________________________________|____________| Islets, Pancreatic | | 49 | __________________________________________________________________________|____________| Parathyroid Gland | | 41 | __________________________________________________________________________|____________| Pituitary Gland | | 49 | __________________________________________________________________________|____________| Thyroid Gland | | 50 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 53 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM - cont | | | | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | | 50 | Histiocytic Sarcoma | | 1 | Sarcoma | | 1 | __________________________________________________________________________|____________| Preputial Gland | | 29 | __________________________________________________________________________|____________| Prostate | | 50 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | | 50 | __________________________________________________________________________|____________| Testes | | 50 | Histiocytic Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | Histiocytic Sarcoma | | 1 | Mast Cell Tumor Malignant, | | | Metastatic, Spleen | | 1 | __________________________________________________________________________|____________| Lymph Node | | 4 | Axillary, Lymphoma Malignant | | | Lymphocytic | | 1 | Bronchial, Lymphoma Malignant | | | Lymphocytic | | 2 | Iliac, Lymphoma Malignant Lymphocytic| | 1 | Inguinal, Lymphoma Malignant | | | Lymphocytic | | 1 | Lumbar, Lymphoma Malignant | | | Lymphocytic | | 1 | Pancreatic, Lymphoma Malignant | | | Lymphocytic | | 2 | Renal, Lymphoma Malignant Lymphocytic| | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | | 46 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 48 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Spleen | | 49 | Lymphoma Malignant Lymphocytic | | 2 | Mast Cell Tumor Malignant | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 54 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Thymus | | 49 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 1 | __________________________________________________________________________|____________| Skin | | 50 | Subcutaneous Tissue, Lipoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Alveolar/Bronchiolar Adenoma | | 12 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 1 | __________________________________________________________________________|____________| Nose | | 50 | __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Ear | | 2 | Pinna, Sarcoma | | 1 | __________________________________________________________________________|____________| Eye | | 1 | __________________________________________________________________________|____________| Harderian Gland | | 3 | Adenoma | | 3 | __________________________________________________________________________|____________| Zymbal's Gland | | 39 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | __________________________________________________________________________|____________| Urinary Bladder | | 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | | 50 | Histiocytic Sarcoma | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 55 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 0| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 8| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 7| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T | ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | A | CONTROL | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 56 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + A + + + + + + +| Adenoma | | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | X | Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X X X X | Hepatocellular Adenoma, Multiple | X X X X X| Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Mesentery | + | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | Capsule, Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + + M + + + + + + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + + | Sarcoma, Metastatic, Uncertain | | _____________________________________________________________________________________________________________________| Page 57 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | Primary Site | X | Abdominal, Hemangiosarcoma, | | Metastatic, Spleen | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + | Renal, Lymphoma Malignant Mixed | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + M + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X | Hemangiosarcoma | X | Lymphoma Malignant Mixed | X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | __________________________________________________________________________| Thymus | + + + + + + + + + + + + M M + + + + + + + M + + +| Lymphoma Malignant Mixed | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M + M M M M M M M M M + M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibroma | X | Subcutaneous Tissue, Lymphoma | | Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | | Sarcoma | | _____________________________________________________________________________________________________________________| Page 58 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 5| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| 9| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| ANIMAL ID | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | X | Sarcoma, Metastatic, Uncertain | | Primary Site | X | Sarcoma, Metastatic, Skeletal Muscle | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + + | __________________________________________________________________________| Harderian Gland | + + + | Adenoma | X X X | Bilateral, Adenoma | | __________________________________________________________________________| Zymbal's Gland | M + + + + + M M + + + + M + + + + + M M + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | X| Renal Tubule, Carcinoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Lymphoma Malignant Mixed | X X | _____________________________________________________________________________________________________________________| Page 59 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + M + M M + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma, Metastatic, Spleen | | Hepatocellular Carcinoma | | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X X X X X | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Mesentery | | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X X | Capsule, Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + M + M M + + + + + + + + + + + + + M + + + +| __________________________________________________________________________| Pituitary Gland | + M + + + + + + + + + + + + + + + + M + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Sarcoma, Metastatic, Uncertain | | _____________________________________________________________________________________________________________________| Page 60 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM - cont | | | | Primary Site | | Abdominal, Hemangiosarcoma, | | Metastatic, Spleen | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + M + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Renal, Lymphoma Malignant Mixed | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X| Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Hemangiosarcoma | | Lymphoma Malignant Mixed | | Sarcoma, Metastatic, Uncertain | | Primary Site | | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + + + M + + + + + + + +| Lymphoma Malignant Mixed | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Fibroma | | Subcutaneous Tissue, Lymphoma | | Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Skeletal Muscle | + | Sarcoma | X | _____________________________________________________________________________________________________________________| Page 61 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 3| 9| 9| 9| 9| 9| 9| 9| 9| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X X | Sarcoma, Metastatic, Uncertain | | Primary Site | | Sarcoma, Metastatic, Skeletal Muscle | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | | __________________________________________________________________________| Harderian Gland | + | Adenoma | | Bilateral, Adenoma | X | __________________________________________________________________________| Zymbal's Gland | + M + M M M + + + + + M + + M M + M + + + + + M +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Renal Tubule, Adenoma | X | Renal Tubule, Carcinoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Lymphoma Malignant Mixed | X| _____________________________________________________________________________________________________________________| Page 62 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | __________________________________________________________________________|____________| Gallbladder | | 47 | __________________________________________________________________________|____________| Intestine Large, Colon | | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 50 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 49 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 48 | Adenoma | | 1 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 49 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 49 | __________________________________________________________________________|____________| Liver | | 50 | Hemangiosarcoma, Metastatic, Spleen | | 1 | Hepatocellular Carcinoma | | 3 | Hepatocellular Adenoma | | 9 | Hepatocellular Adenoma, Multiple | | 10 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Mesentery | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Pancreas | | 50 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Salivary Glands | | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | | 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 50 | Adenoma | | 3 | Capsule, Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | | 50 | __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________|____________| Parathyroid Gland | | 43 | __________________________________________________________________________|____________| Pituitary Gland | | 48 | __________________________________________________________________________|____________| Thyroid Gland | | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 63 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 2 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | Abdominal, Hemangiosarcoma, | | | Metastatic, Spleen | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | | 50 | Sarcoma | | 1 | __________________________________________________________________________|____________| Preputial Gland | | 23 | __________________________________________________________________________|____________| Prostate | | 49 | __________________________________________________________________________|____________| Seminal Vesicle | | 50 | __________________________________________________________________________|____________| Testes | | 50 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | __________________________________________________________________________|____________| Lymph Node | | 1 | Renal, Lymphoma Malignant Mixed | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | | 49 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 49 | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 3 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Spleen | | 50 | Hemangioma | | 1 | Hemangiosarcoma | | 1 | Lymphoma Malignant Mixed | | 1 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | __________________________________________________________________________|____________| Thymus | | 45 | Lymphoma Malignant Mixed | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 64 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 2 | __________________________________________________________________________|____________| Skin | | 50 | Subcutaneous Tissue, Fibroma | | 1 | Subcutaneous Tissue, Lymphoma | | | Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 50 | __________________________________________________________________________|____________| Skeletal Muscle | | 1 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Alveolar/Bronchiolar Adenoma | | 8 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | | 3 | Sarcoma, Metastatic, Uncertain | | | Primary Site | | 1 | Sarcoma, Metastatic, Skeletal Muscle | | 1 | __________________________________________________________________________|____________| Nose | | 50 | __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Harderian Gland | | 4 | Adenoma | | 3 | Bilateral, Adenoma | | 1 | __________________________________________________________________________|____________| Zymbal's Gland | | 34 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Renal Tubule, Adenoma | | 2 | Renal Tubule, Carcinoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | | 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 65 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | A | 1000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | LOW MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS - cont | | | | | | Lymphoma Malignant Lymphocytic | | 1 | Lymphoma Malignant Mixed | | 3 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 66 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 2| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 4| 8| 8| 8| 2| 8| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + I + + M + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + A + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Hepatocellular Carcinoma | X X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | M + + + + + + + + + I + + + + + + + + + + + + M +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + I + + + + + + + + + + + + + M + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | + | Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | _____________________________________________________________________________________________________________________| Page 67 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 2| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 4| 8| 8| 8| 2| 8| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | X | Bronchial, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | Mediastinal, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Thymus | + M + + + + + + + + + + + + M + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M I M I M M M M M M + + M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X X| Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | __________________________________________________________________________| Zymbal's Gland | + + + + + + + + + + + M + + M + M + + M + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 68 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 4| 3| 1| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 0| 3| 2| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 1| 7| 7| 7| 7| 7| 7| 4| 8| 8| 8| 2| 8| 2| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| Page 69 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 8| 8| 8| 0| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + A + + M + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Rectum | + + + A + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + A + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Duodenum | + + + A + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + A + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Small, Ileum | + + + A + + + + + + + + + + + + + + + A + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Hepatocellular Carcinoma | X X X X X | Hepatocellular Adenoma | X X X | Hepatocellular Adenoma, Multiple | X X X X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Sarcoma | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| Adenoma | X | __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + + + + + + + + + M + + + M + + M M + + M + + + +| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | __________________________________________________________________________| Tissue NOS | | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | _____________________________________________________________________________________________________________________| Page 70 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 8| 8| 8| 0| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM - cont | | | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Alveolar/Bronchiolar Carcinoma, | | Metastatic, Lung | | Bronchial, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | Mediastinal, Alveolar/Bronchiolar | | Carcinoma, Metastatic, Lung | | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + M + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Thymus | + + + + + + + + + + M M + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | + M M M M M M M M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangiosarcoma | X | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Eye | + | __________________________________________________________________________| Harderian Gland | + + | Adenoma | X X | __________________________________________________________________________| Zymbal's Gland | M + + + + + + + + + M + + + + M + M + + + + + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 71 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| | 8| 8| 8| 0| 8| 8| 8| 8| 8| 8| 6| 8| 8| 8| 8| 8| 8| 8| 8| 5| 8| 8| 8| 8| 8| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| ANIMAL ID | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 3000 PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| URINARY SYSTEM - cont | | | | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| Page 72 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | __________________________________________________________________________|____________| Gallbladder | | 46 | __________________________________________________________________________|____________| Intestine Large, Colon | | 50 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 48 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 48 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 47 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 49 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 47 | __________________________________________________________________________|____________| Liver | | 50 | Hemangiosarcoma | | 1 | Hepatocellular Carcinoma | | 8 | Hepatocellular Adenoma | | 7 | Hepatocellular Adenoma, Multiple | | 10 | __________________________________________________________________________|____________| Pancreas | | 50 | __________________________________________________________________________|____________| Salivary Glands | | 50 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | __________________________________________________________________________|____________| Stomach, Glandular | | 50 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Sarcoma | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 50 | Adenoma | | 1 | __________________________________________________________________________|____________| Adrenal Medulla | | 50 | __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________|____________| Parathyroid Gland | | 42 | __________________________________________________________________________|____________| Pituitary Gland | | 48 | __________________________________________________________________________|____________| Thyroid Gland | | 50 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | __________________________________________________________________________|____________| Tissue NOS | | 1 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Epididymis | | 50 | __________________________________________________________________________|____________| Preputial Gland | | 23 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 73 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ GENITAL SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Prostate | | 50 | __________________________________________________________________________|____________| Seminal Vesicle | | 50 | __________________________________________________________________________|____________| Testes | | 50 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | __________________________________________________________________________|____________| Lymph Node | | 2 | Alveolar/Bronchiolar Carcinoma, | | | Metastatic, Lung | | 1 | Bronchial, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | Mediastinal, Alveolar/Bronchiolar | | | Carcinoma, Metastatic, Lung | | 1 | __________________________________________________________________________|____________| Lymph Node, Mandibular | | 49 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 50 | __________________________________________________________________________|____________| Spleen | | 50 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Thymus | | 46 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 3 | __________________________________________________________________________|____________| Skin | | 50 | Subcutaneous Tissue, Hemangiosarcoma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Alveolar/Bronchiolar Adenoma | | 7 | Alveolar/Bronchiolar Carcinoma | | 2 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 3 | __________________________________________________________________________|____________| Nose | | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 74 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | A | 3000 PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | MID MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Eye | | 2 | __________________________________________________________________________|____________| Harderian Gland | | 4 | Adenoma | | 4 | __________________________________________________________________________|____________| Zymbal's Gland | | 42 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | | 50 | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | | 50 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 75 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + M + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + A + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + A + + + + + + +| Carcinoma | X| __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | | Hemangiosarcoma | | Hemangiosarcoma, Metastatic, Spleen | | Hepatoblastoma | | Hepatocellular Carcinoma | X X X X X X X X X | Hepatocellular Adenoma | X X X X | Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X X| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Squamous Cell Papilloma | | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M M + M + + + + + + + + + + + + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 76 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Lymphoma Malignant Lymphocytic | | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ductus Deferens | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Preputial Gland | + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Interstitial Cell, Adenoma | X | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | | Deep Cervical, Lymphoma Malignant | | Lymphocytic | | Mediastinal, Lymphoma Malignant | | Lymphocytic | | Renal, Lymphoma Malignant Lymphocytic| | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | | Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Thymus | + + + + + + + + + M + M + + + + + + M + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M M M M M M M M M M + M + M M M + M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangioma | | _____________________________________________________________________________________________________________________| Page 77 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 1| 3| 3| 3| | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| ANIMAL ID | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | X X X | Alveolar/Bronchiolar Adenoma, | | Multiple | | Alveolar/Bronchiolar Carcinoma | | Hepatocellular Carcinoma, Metastatic,| | Liver | | Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | + + + + M + M + + + + M M + + + + M + + + + + M M| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | Renal Tubule, Adenoma | | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | X | Lymphoma Malignant Lymphocytic | | _____________________________________________________________________________________________________________________| Page 78 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ALIMENTARY SYSTEM | | | | __________________________________________________________________________| Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Gallbladder | + + + + + + + + + + + + + + + + + + + + + + M M +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + A +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + A + + + +| __________________________________________________________________________| Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + A + + A +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| Carcinoma | X X | __________________________________________________________________________| Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + A + + A +| __________________________________________________________________________| Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangioma | X| Hemangiosarcoma | X | Hemangiosarcoma, Metastatic, Spleen | X | Hepatoblastoma | X | Hepatocellular Carcinoma | X X X X X X X X | Hepatocellular Adenoma | X X X X X | Hepatocellular Adenoma, Multiple | X X X X X X X X X X X X X X X| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Squamous Cell Papilloma | X | __________________________________________________________________________| Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| CARDIOVASCULAR SYSTEM | | | | __________________________________________________________________________| Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM | | | | __________________________________________________________________________| Adrenal Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Adrenal Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Parathyroid Gland | + M + + + + + + + + + M + + + + + + + + + + + + M| __________________________________________________________________________| Pituitary Gland | + + + + + + + + + + + + + + + M + + M + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| Page 79 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| ENDOCRINE SYSTEM - cont | | | | Lymphoma Malignant Lymphocytic | X | Follicular Cell, Adenoma | X | _____________________________________________________________________________________________________________________| GENERAL BODY SYSTEM | | | | None | | _____________________________________________________________________________________________________________________| GENITAL SYSTEM | | | | __________________________________________________________________________| Ductus Deferens | + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Preputial Gland | + + + + + + + + + + + + + | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Interstitial Cell, Adenoma | | _____________________________________________________________________________________________________________________| HEMATOPOIETIC SYSTEM | | | | __________________________________________________________________________| Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| __________________________________________________________________________| Lymph Node | + + + | Deep Cervical, Lymphoma Malignant | | Lymphocytic | X | Mediastinal, Lymphoma Malignant | | Lymphocytic | X X | Renal, Lymphoma Malignant Lymphocytic| X X | __________________________________________________________________________| Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + M +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X X | __________________________________________________________________________| Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| Hemangiosarcoma | X | Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Thymus | + + M + + M + + + + M + + + + M + + + + M + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM | | | | __________________________________________________________________________| Mammary Gland | M M M + M M M I M M M M M M M M M M M M M M M M M| __________________________________________________________________________| Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| Subcutaneous Tissue, Hemangioma | X | _____________________________________________________________________________________________________________________| Page 80 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 _____________________________________________________________________________________________________________________ | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 5| 7| DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 6| 3| | 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 8| 7| _____________________________________________________________________________________________________________________| | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| ANIMAL ID | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 10000PPM | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| _____________________________________________________________________________________________________________________| INTEGUMENTARY SYSTEM - cont | | | | _____________________________________________________________________________________________________________________| MUSCULOSKELETAL SYSTEM | | | | __________________________________________________________________________| Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| NERVOUS SYSTEM | | | | __________________________________________________________________________| Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| RESPIRATORY SYSTEM | | | | __________________________________________________________________________| Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| Alveolar/Bronchiolar Adenoma | | Alveolar/Bronchiolar Adenoma, | | Multiple | X | Alveolar/Bronchiolar Carcinoma | X | Hepatocellular Carcinoma, Metastatic,| | Liver | X X X | Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | __________________________________________________________________________| Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| _____________________________________________________________________________________________________________________| SPECIAL SENSES SYSTEM | | | | __________________________________________________________________________| Zymbal's Gland | M + + M + + + + + + + M + + + + + + M M + M + + +| _____________________________________________________________________________________________________________________| URINARY SYSTEM | | | | __________________________________________________________________________| Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | Renal Tubule, Adenoma | X | __________________________________________________________________________| Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| Lymphoma Malignant Lymphocytic | X | _____________________________________________________________________________________________________________________| SYSTEMIC LESIONS | | __________________________________________________________________________| Multiple Organs | + + + + + + + + + + + + + + + + + + + + + + + + +| Histiocytic Sarcoma | | Lymphoma Malignant Lymphocytic | X X | _____________________________________________________________________________________________________________________| Page 81 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. 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DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Esophagus | | 50 | __________________________________________________________________________|____________| Gallbladder | | 47 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Large, Colon | | 49 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Large, Rectum | | 49 | __________________________________________________________________________|____________| Intestine Large, Cecum | | 48 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Intestine Small, Duodenum | | 49 | __________________________________________________________________________|____________| Intestine Small, Jejunum | | 49 | Carcinoma | | 3 | __________________________________________________________________________|____________| Intestine Small, Ileum | | 48 | __________________________________________________________________________|____________| Liver | | 50 | Hemangioma | | 1 | Hemangiosarcoma | | 1 | Hemangiosarcoma, Metastatic, Spleen | | 1 | Hepatoblastoma | | 1 | Hepatocellular Carcinoma | | 17 | Hepatocellular Adenoma | | 9 | Hepatocellular Adenoma, Multiple | | 31 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Pancreas | | 50 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Salivary Glands | | 50 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Stomach, Forestomach | | 50 | Lymphoma Malignant Lymphocytic | | 1 | Squamous Cell Papilloma | | 1 | __________________________________________________________________________|____________| Stomach, Glandular | | 50 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | | | | __________________________________________________________________________|____________| Heart | | 50 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | | | | __________________________________________________________________________|____________| Adrenal Cortex | | 50 | __________________________________________________________________________|____________| Adrenal Medulla | | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 82 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - cont | | | | | | __________________________________________________________________________|____________| Islets, Pancreatic | | 50 | __________________________________________________________________________|____________| Parathyroid Gland | | 43 | __________________________________________________________________________|____________| Pituitary Gland | | 48 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Thyroid Gland | | 50 | Lymphoma Malignant Lymphocytic | | 1 | Follicular Cell, Adenoma | | 2 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | | | | __________________________________________________________________________|____________| Ductus Deferens | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Epididymis | | 50 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Preputial Gland | | 21 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Prostate | | 50 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Seminal Vesicle | | 50 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Testes | | 50 | Lymphoma Malignant Lymphocytic | | 1 | Interstitial Cell, Adenoma | | 1 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | | | | __________________________________________________________________________|____________| Bone Marrow | | 50 | __________________________________________________________________________|____________| Lymph Node | | 3 | Deep Cervical, Lymphoma Malignant | | | Lymphocytic | | 1 | Mediastinal, Lymphoma Malignant | | | Lymphocytic | | 2 | Renal, Lymphoma Malignant Lymphocytic| | 2 | __________________________________________________________________________|____________| Lymph Node, Mandibular | | 48 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Lymph Node, Mesenteric | | 50 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________|____________| Spleen | | 50 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 83 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont | | | | | | Hemangiosarcoma | | 1 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Thymus | | 42 | Lymphoma Malignant Lymphocytic | | 1 | _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | | | | __________________________________________________________________________|____________| Mammary Gland | | 4 | __________________________________________________________________________|____________| Skin | | 50 | Subcutaneous Tissue, Hemangioma | | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | | | | __________________________________________________________________________|____________| Bone | | 50 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | | | | __________________________________________________________________________|____________| Brain | | 50 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | | | | __________________________________________________________________________|____________| Lung | | 50 | Alveolar/Bronchiolar Adenoma | | 3 | Alveolar/Bronchiolar Adenoma, | | | Multiple | | 1 | Alveolar/Bronchiolar Carcinoma | | 1 | Hepatocellular Carcinoma, Metastatic,| | | Liver | | 3 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Nose | | 50 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________|____________| Trachea | | 50 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | | | | __________________________________________________________________________|____________| Zymbal's Gland | | 37 | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | | | | __________________________________________________________________________|____________| Kidney | | 50 | Lymphoma Malignant Lymphocytic | | 1 | Renal Tubule, Adenoma | | 1 | __________________________________________________________________________|____________| Urinary Bladder | | 50 | Lymphoma Malignant Lymphocytic | | 1 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 84 NTP Experiment-Test: 05130-02 NEOPLASMS BY INDIVIDUAL ANIMAL Report: PEIRPT04 Study Type: CHRONIC C. I. DIRECT BLUE 218 Date: 04/03/97 Route: DOSED FEED Time: 12:13:26 __________________________________________________________________________________________________________________________________ | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | | DAY ON TEST | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| | | _____________________________________________________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | B6C3F1 MICE MALE | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | T | ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | A | 10000PPM | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | L | HIGHMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS | | | __________________________________________________________________________|____________| Multiple Organs | | 50 | Histiocytic Sarcoma | | 1 | Lymphoma Malignant Lymphocytic | | 2 | __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with tumor + : Tissue examined microscopically M : Missing tissue X : Lesion present A : Autolysis precludes evaluation I : Insufficient tissue BLANK : Not examined microscopically Page 85 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------