TDMS Study 05135-07 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Northwest ISOPRENE DATE: 09/24/97 EXPERIMENT: 05135 TEST: 07 TIME: 10:01:53 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1 CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61825B PATHOLOGIST: GRUMBEIN, S. CAS: 78-79-5 ------------------------------------------------------------------------------------------------------------------------------------ 2 YEAR CHRONIC REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11 LAB: Battelle Northwest ISOPRENE DATE: 09/24/97 EXPERIMENT: 05135 TEST: 07 TIME: 10:01:53 TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE CONT: NO1-ES-25335 ROUTE: RESPIRATORY EXPOSURE WHOLE BODY NTP C#: 61825B PATHOLOGIST: GRUMBEIN, S. CAS: 78-79-5 ISOPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 733 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = CONTROL | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 32 CENSORED DEATHS 0 TERMINAL 18 | | | | UNCENSORED DEATHS | | 235 342 440 454 468 482 502 518 539 547 | | 551 555 564 592 597 600 604 652 652 659 | | 664 671 672 675 686 694 704 721 723 723 | | 724 728 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 220 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 | | | | UNCENSORED DEATHS | | 398 420 455 499 510 535 538 549 559 581 | | 588 592 597 602 604 629 635 652 657 657 | | 657 664 670 671 682 693 698 702 702 703 | | 714 717 719 723 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 700 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 | | | | UNCENSORED DEATHS | | 454 454 469 510 518 521 537 541 547 555 | | 566 566 576 580 591 594 621 655 664 667 | | 667 668 670 671 681 683 684 686 692 695 | | 706 712 722 727 728 | | CENSORED DEATHS | | NONE | | | ================================================================================== ISOPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 733 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 7000 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 35 CENSORED DEATHS 0 TERMINAL 15 | | | | UNCENSORED DEATHS | | 26 222 361 478 517 548 560 566 581 581 | | 588 588 611 612 618 621 622 630 664 664 | | 667 667 668 680 681 685 686 691 708 709 | | 721 721 723 727 727 | | CENSORED DEATHS | | NONE | | | ================================================================================== ISOPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA MALE RATS FIRST TERMINAL SACRIFICE AT 733 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 733 (A) | | | |--------------------------------------------------------------------------------| | | | |CONTROL | 100.0 100.0 98.0 96.0 96.0 88.0 82.0 66.0 58.0 36.0 | | | | | | | |220 PPM | 100.0 100.0 100.0 100.0 96.0 94.0 86.0 70.0 56.0 32.0 | | | | | | | |700 PPM | 100.0 100.0 100.0 100.0 100.0 94.0 84.0 68.0 62.0 30.0 | | | | | | | |7000 PPM | 98.0 98.0 96.0 94.0 94.0 92.0 90.0 76.0 60.0 30.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | CONTROL 220 PPM 700 PPM 7000 PPM | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 36.0% 32.0% 30.0% 30.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.944 P=0.847 P=0.726 P=0.807 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 591.8 616.8 616.5 603.4 | |NATURAL DEATHS (C) | (21.0) (15.1) (14.0) (24.6) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 642.6 654.0 651.5 642.3 | |(STANDARD ERROR) | (16.5) (12.8) (12.4) (19.1) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) ISOPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 734 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = CONTROL | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 | | | | UNCENSORED DEATHS | | 398 454 482 539 552 580 580 596 629 630 | | 648 657 657 670 671 684 705 714 727 727 | | 728 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 220 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 20 CENSORED DEATHS 0 TERMINAL 30 | | | | UNCENSORED DEATHS | | 370 482 587 601 602 622 626 638 643 664 | | 670 670 685 686 693 694 695 714 727 727 | | CENSORED DEATHS | | NONE | | | |--------------------------------------------------------------------------------| | DOSE = 700 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 | | | | UNCENSORED DEATHS | | 111 427 508 510 539 547 566 580 581 604 | | 611 617 638 672 699 708 710 710 713 721 | | 723 727 | | CENSORED DEATHS | | NONE | | | ================================================================================== ISOPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 734 DAYS INDIVIDUAL SURVIVAL TIMES (DAYS) ================================================================================== | DOSE = 7000 PPM | | --------------------- | | | | TOTAL 50 UNCENSORED DEATHS 23 CENSORED DEATHS 0 TERMINAL 27 | | | | UNCENSORED DEATHS | | 114 415 432 464 482 490 497 594 594 621 | | 625 630 652 653 664 664 681 681 709 713 | | 713 714 727 | | CENSORED DEATHS | | NONE | | | ================================================================================== ISOPRENE STATISTICAL ANALYSIS OF SURVIVAL DATA FEMALE RATS FIRST TERMINAL SACRIFICE AT 734 DAYS ================================================================================== | KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) | | | |--------------------------------------------------------------------------------| | DOSE TIME (DAYS) | | 90 180 270 365 425 485 545 605 665 734 (A) | | | |--------------------------------------------------------------------------------| | | | |CONTROL | 100.0 100.0 100.0 100.0 98.0 94.0 92.0 84.0 74.0 58.0 | | | | | | | |220 PPM | 100.0 100.0 100.0 100.0 98.0 96.0 96.0 90.0 80.0 60.0 | | | | | | | |700 PPM | 100.0 98.0 98.0 98.0 98.0 96.0 90.0 80.0 74.0 56.0 | | | | | | | |7000 PPM | 100.0 98.0 98.0 98.0 96.0 90.0 86.0 82.0 68.0 54.0 | | | | | | | ================================================================================== ================================================================================== | SURVIVAL SUMMARY STATISTICS | | | | | |--------------------------------------------------------------------------------| | DOSE | | | | CONTROL 220 PPM 700 PPM 7000 PPM | | | |--------------------------------------------------------------------------------| |SURVIVAL AT END OF STUDY| 58.0% 60.0% 56.0% 54.0% | |(KAPLAN-MEIER) | | | | | |SIGNIFICANCE (B) | P=0.589 P=0.889N P=0.930 P=0.736 | |(LIFE TABLE) | | | | | |MEAN DAY OF | 620.4 639.8 601.0 588.2 | |NATURAL DEATHS (C) | (20.4) (19.2) (29.6) (29.7) | |(STANDARD ERROR) | | | | | |MEAN LIFE SPAN (D) | 686.3 696.3 675.5 666.9 | |(STANDARD ERROR) | (11.6) (10.0) (16.0) (17.0) | | | | ================================================================================== (A) FIRST TERMINAL SACRIFICE (B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT. SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS (COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N". (C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE (D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE) ISOPRENE KAPLAN-MEIER SURVIVAL CURVES CONTROL = 1 220 PPM = 2 700 PPM = 3 7000 PPM = 4 ------------------------------------------------------ SPECIES=RATS SEX=MALE ------------------------------------------------------- Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | 104 + | | 1 4 1 2 3 | 4 4 1 1 2 2 96 + 4 1 4 2 1 2 3 | 4 1 1 3 4 23 | 1 1 4 223 | 1 1 23 3 2 4 88 + 1 1 3 3 44 | 1 1 23244 | 1 13224 4 | 1 12 2 P 80 + 33 22 E | 11 2 2 R | 11 34 22 4 C | 1 1 E 72 + 3 11244 N | 2 2 T | 311 322 | 1 342 1 S 64 + 4 3 3 U | 1 13 R | 44 V | 2 11 I 56 + 22 V | 114 A | 211 L | 121 48 + 211 | 4421 1 | 33 411 | 33 40 + 3224 | 322 | 341 1 | 22 32 + 2 2 | 3 3 | | 24 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 38 obs hidden. ISOPRENE KAPLAN-MEIER SURVIVAL CURVES CONTROL = 1 220 PPM = 2 700 PPM = 3 7000 PPM = 4 ----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------ Plot of SURVIVAL*WEEK. Symbol is value of DOSE. | | 104 + | | 1 34 2 1 | 34 2 1 43 1 2 96 + 434 1 1 3 2 | 4 4 1 1 2 2 P | 4 4 3 1 1 E | 44 3 1 1 2 2 R 88 + 44 3 3 22 C | 4 3 1 41 2 2 E | 1 1 N | 3 4 3 4 2 2 T 80 + 3341 1 22 | 33 11 S | 34 3 4 2 2 U | 3 1 1 R 72 + 4 43 223 V | 1 122 3 I | 4 1 1 V | 211 A 64 + 4 1 1 L | 33 | 32 2 | 1 1 56 + 4 3 3 | 4 4 | | 48 + | --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-- 0 10 20 30 40 50 60 70 80 90 100 110 WEEK NOTE: 17 obs hidden.