National Toxicology Program

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TDMS Study 05136-07 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       CHLOROPRENE                                      DATE: 09/13/96       
EXPERIMENT: 05136 TEST: 07                                                                                     TIME: 16:04:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05291                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 50522B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 0000126-99-8    
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    
               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       CHLOROPRENE                                      DATE: 09/13/96       
EXPERIMENT: 05136 TEST: 07                                                                                     TIME: 16:04:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05291                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 50522B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 0000126-99-8    


                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    
                                                    ----------------
                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Clitoral/Preputial Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Larynx
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       CHLOROPRENE                                      DATE: 09/13/96       
EXPERIMENT: 05136 TEST: 07                                                                                     TIME: 16:04:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05291                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 50522B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 0000126-99-8    


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                         IN THE ANALYSIS OF THE STUDY OF 9-8CHLOROPRENE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Adrenal Medulla               Pheochromocytoma Benign
                                            Pheochromocytoma: Benign, Complex, Malignant, NOS
              Lung                          Alveolar/Bronchiolar Carcinoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)
                                            Papilloma Squamous or Papilloma
                                            Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
              Oral Mucosa                   Squamous Cell Papilloma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Prostate                      Adenoma
              Thyroid Gland: C-Cell         Adenoma
              Thyroid Gland: Follicular Cell
                                            Adenoma
                                            Carcinoma or Adenoma
              Tongue                        Squamous Cell Carcinoma or Papilloma Squamous
                                            Squamous Cell Papilloma
              All Organs                    Histiocytic Sarcoma
                                            Mesothelioma: Benign, Malignant, NOS
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Northwest                                       CHLOROPRENE                                      DATE: 09/13/96       
EXPERIMENT: 05136 TEST: 07                                                                                     TIME: 16:04:16       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05291                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 50522B       
PATHOLOGIST: S. GRUMBEIN                                                                                       CAS: 0000126-99-8    


                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                         IN THE ANALYSIS OF THE STUDY OF 9-8CHLOROPRENE
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------
              Clitoral/Preputial Gland      Carcinoma
                                            Carcinoma or Adenoma
              Kidney: Renal Tubule          Adenoma
              Lung                          Alveolar/Bronchiolar Adenoma
                                            Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
              Mammary Gland                 Fibroadenoma
                                            Fibroma, Fibroadenoma or Adenoma
                                            Fibroma, Fibroadenoma, Carcinoma, or Adenoma
              Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)
                                            Papilloma Squamous or Papilloma
                                            Squamous Cell Carcinoma
                                            Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
              Pituitary Gland: Pars Distalis or Unspecified Site
                                            Adenoma
              Thyroid Gland: Follicular Cell
                                            Carcinoma or Adenoma
              Tongue                        Squamous Cell Carcinoma
                                            Squamous Cell Carcinoma or Papilloma Squamous
                                            Squamous Cell Papilloma
              Urinary Bladder               Carcinoma
                                            Carcinoma or Papilloma
              Uterus                        Polyp Stromal
              All Organs                    Hemangiosarcoma
                                            Hemangiosarcoma or Hemangioma
                                            Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
                                            Benign Tumors
                                            Malignant Tumors
                                            Malignant and Benign Tumors
              ====================================================================================================
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE   1
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    1/49 (2%)    0/50 (0%)  |  2/49 (4%)    4/50 (8%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |  11.0%         0.0%        10.0%         0.0%      |   6.5%        12.1%         7.7%         4.8%      |
|TERMINAL (d)           |  1/13 (8%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  1/29 (3%)    2/28 (7%)    2/26 (8%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   637          ---          705          ---       |   697          630          733 (T)      733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.399N     P=0.272N     P=0.701N     P=0.401N   |  P=0.348N     P=0.347      P=0.649      P=0.594N   |
|INCIDENTAL TUMOR       |  P=0.285N     P=0.319N     P=0.598N     P=0.360N   |  P=0.274N     P=0.329      P=0.644      P=0.536N   |
|LOGISTIC REGRESSION    |  P=0.315N     P=0.248N     P=0.631N     P=0.311N   |  P=0.287N     P=0.349      P=0.659      P=0.549N   |
|COCHRAN-ARMITAGE       |  P=0.236N                                          |  P=0.240N                                          |
|FISHER EXACT           |               P=0.247N     P=0.508N     P=0.247N   |               P=0.349      P=0.684N     P=0.492N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 19/50 (38%)  20/50 (40%)  21/49 (43%)  18/50 (36%) |  3/49 (6%)    3/50 (6%)    3/50 (6%)    3/50 (6%)  |
|ADJUSTED (b)           |  76.2%        78.0%        82.2%       100.0%      |  10.3%         9.4%        10.9%        13.6%      |
|TERMINAL (d)           |  8/13 (62%)   4/9 (44%)    2/5 (40%)    4/4 (100%) |  3/29 (10%)   1/28 (4%)    2/26 (8%)    2/21 (10%) |
|FIRST INCIDENCE (DAYS) |   576          534          497          540       |   733 (T)      681          693          729       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.029 *    P=0.280      P=0.027 *    P=0.022 *  |  P=0.434      P=0.659      P=0.613      P=0.511    |
|INCIDENTAL TUMOR       |  P=0.461      P=0.565N     P=0.198      P=0.362    |  P=0.522      P=0.622N     P=0.603      P=0.562    |
|LOGISTIC REGRESSION    |  P=0.312      P=0.444      P=0.150      P=0.237    |  P=0.494      P=0.641N     P=0.614      P=0.543    |
|COCHRAN-ARMITAGE       |  P=0.422N                                          |  P=0.586N                                          |
|FISHER EXACT           |               P=0.500      P=0.387      P=0.500N   |               P=0.651N     P=0.651N     P=0.651N   |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE   2
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 19/50 (38%)  21/50 (42%)  21/49 (43%)  18/50 (36%) |  3/49 (6%)    4/50 (8%)    3/50 (6%)    3/50 (6%)  |
|ADJUSTED (b)           |  76.2%        82.4%        82.2%       100.0%      |  10.3%        12.8%        10.9%        13.6%      |
|TERMINAL (d)           |  8/13 (62%)   5/9 (56%)    2/5 (40%)    4/4 (100%) |  3/29 (10%)   2/28 (7%)    2/26 (8%)    2/21 (10%) |
|FIRST INCIDENCE (DAYS) |   576          534          497          540       |   733 (T)      681          693          729       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.031 *    P=0.214      P=0.027 *    P=0.022 *  |  P=0.494      P=0.495      P=0.613      P=0.511    |
|INCIDENTAL TUMOR       |  P=0.474      P=0.508      P=0.198      P=0.362    |  P=0.578      P=0.538      P=0.603      P=0.562    |
|LOGISTIC REGRESSION    |  P=0.336      P=0.356      P=0.150      P=0.237    |  P=0.555      P=0.528      P=0.614      P=0.543    |
|COCHRAN-ARMITAGE       |  P=0.388N                                          |  P=0.513N                                          |
|FISHER EXACT           |               P=0.419      P=0.387      P=0.500N   |               P=0.511      P=0.651N     P=0.651N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/50 (6%)    4/48 (8%)    1/50 (2%)  |  2/46 (4%)    6/48 (13%)   2/46 (4%)    2/46 (4%)  |
|ADJUSTED (b)           |  12.3%        24.7%        21.6%         3.1%      |   6.8%        18.1%         7.0%         5.3%      |
|TERMINAL (d)           |  1/13 (8%)    2/9 (22%)    0/5 (0%)     0/4 (0%)   |  1/28 (4%)    3/27 (11%)   1/22 (5%)    0/19 (0%)  |
|FIRST INCIDENCE (DAYS) |   534          613          497          601       |   721          525          601          609       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.451N     P=0.567      P=0.331      P=0.440N   |  P=0.433N     P=0.143      P=0.632      P=0.623    |
|INCIDENTAL TUMOR       |  P=0.293N     P=0.534      P=0.559      P=0.378N   |  P=0.289N     P=0.193      P=0.671      P=0.649N   |
|LOGISTIC REGRESSION    |  P=0.239N     P=0.655      P=0.533      P=0.285N   |  P=0.324N     P=0.145      P=0.667      P=0.693N   |
|COCHRAN-ARMITAGE       |  P=0.230N                                          |  P=0.321N                                          |
|FISHER EXACT           |               P=0.661N     P=0.477      P=0.309N   |               P=0.148      P=0.692N     P=0.692N   |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE   3
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/50 (6%)    4/48 (8%)    1/50 (2%)  |  0/46 (0%)    6/48 (13%)   4/46 (9%)    2/46 (4%)  |
|ADJUSTED (b)           |  17.3%        24.8%        29.2%        25.0%      |   0.0%        18.1%        13.3%         5.1%      |
|TERMINAL (d)           |  2/13 (15%)   2/9 (22%)    1/5 (20%)    1/4 (25%)  |  0/28 (0%)    3/27 (11%)   2/22 (9%)    0/19 (0%)  |
|FIRST INCIDENCE (DAYS) |   541          637          497          733 (T)   |   ---          630          544          572       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.551N     P=0.553      P=0.237      P=0.649N   |  P=0.508      P=0.021 *    P=0.049 *    P=0.225    |
|INCIDENTAL TUMOR       |  P=0.457N     P=0.531      P=0.378      P=0.608N   |  P=0.498N     P=0.017 *    P=0.102      P=0.321    |
|LOGISTIC REGRESSION    |  P=0.318N     P=0.642      P=0.438      P=0.431N   |  P=0.555N     P=0.019 *    P=0.074      P=0.290    |
|COCHRAN-ARMITAGE       |  P=0.230N                                          |  P=0.566N                                          |
|FISHER EXACT           |               P=0.661N     P=0.477      P=0.309N   |               P=0.015 *    P=0.058      P=0.247    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/50 (12%)   6/50 (12%)   7/48 (15%)   2/50 (4%)  |  2/46 (4%)   12/48 (25%)   5/46 (11%)   3/46 (7%)  |
|ADJUSTED (b)           |  28.6%        48.0%        43.3%        27.3%      |   6.8%        34.0%        17.7%         7.3%      |
|TERMINAL (d)           |  3/13 (23%)   4/9 (44%)    1/5 (20%)    1/4 (25%)  |  1/28 (4%)    6/27 (22%)   3/22 (14%)   0/19 (0%)  |
|FIRST INCIDENCE (DAYS) |   534          613          497          601       |   721          525          544          572       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.418N     P=0.463      P=0.196      P=0.399N   |  P=0.364N     P=0.007 **   P=0.159      P=0.432    |
|INCIDENTAL TUMOR       |  P=0.245N     P=0.420      P=0.421      P=0.324N   |  P=0.182N     P=0.008 **   P=0.247      P=0.595    |
|LOGISTIC REGRESSION    |  P=0.153N     P=0.600      P=0.437      P=0.172N   |  P=0.220N     P=0.005 **   P=0.202      P=0.545    |
|COCHRAN-ARMITAGE       |  P=0.099N                                          |  P=0.217N                                          |
|FISHER EXACT           |               P=0.620N     P=0.468      P=0.134N   |               P=0.005 **   P=0.217      P=0.500    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE   4
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/50 (6%)    2/49 (4%)    2/50 (4%)  |  2/49 (4%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |  17.6%        18.1%        16.0%        20.0%      |   6.6%         3.6%         3.8%         0.0%      |
|TERMINAL (d)           |  2/13 (15%)   1/9 (11%)    0/5 (0%)     0/4 (0%)   |  1/29 (3%)    1/28 (4%)    1/26 (4%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   576          525          609          691       |   702          733 (T)      733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.492      P=0.574      P=0.601      P=0.529    |  P=0.227N     P=0.501N     P=0.541N     P=0.291N   |
|INCIDENTAL TUMOR       |  P=0.490N     P=0.598      P=0.654N     P=0.636N   |  P=0.209N     P=0.469N     P=0.551N     P=0.235N   |
|LOGISTIC REGRESSION    |  P=0.515N     P=0.651      P=0.627N     P=0.659N   |  P=0.209N     P=0.483N     P=0.536N     P=0.263N   |
|COCHRAN-ARMITAGE       |  P=0.393N                                          |  P=0.173N                                          |
|FISHER EXACT           |               P=0.661N     P=0.510N     P=0.500N   |               P=0.492N     P=0.492N     P=0.242N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    5/50 (10%)   3/49 (6%)    1/50 (2%)  |  1/49 (2%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |  13.2%        29.1%        14.9%         5.3%      |   3.4%         2.6%         2.6%         0.0%      |
|TERMINAL (d)           |  0/13 (0%)    1/9 (11%)    0/5 (0%)     0/4 (0%)   |  1/29 (3%)    0/28 (0%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   489          603          609          651       |   733 (T)      679          601          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.337N     P=0.315      P=0.488      P=0.444N   |  P=0.360N     P=0.749N     P=0.740      P=0.564N   |
|INCIDENTAL TUMOR       |  P=0.123N     P=0.478      P=0.608N     P=0.196N   |  P=0.278N     P=0.728N     P=0.738N     P=0.564N   |
|LOGISTIC REGRESSION    |  P=0.181N     P=0.346      P=0.652      P=0.306N   |  P=0.311N     P=0.757N     P=0.754N     P=0.564N   |
|COCHRAN-ARMITAGE       |  P=0.140N                                          |  P=0.314N                                          |
|FISHER EXACT           |               P=0.357      P=0.651      P=0.309N   |               P=0.747N     P=0.747N     P=0.495N   |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE   5
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/50 (12%)   8/50 (16%)   5/49 (10%)   3/50 (6%)  |  3/49 (6%)    2/50 (4%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |  28.4%        42.8%        28.6%        24.2%      |   9.9%         6.1%         6.3%         0.0%      |
|TERMINAL (d)           |  2/13 (15%)   2/9 (22%)    0/5 (0%)     0/4 (0%)   |  2/29 (7%)    1/28 (4%)    1/26 (4%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   489          525          609          651       |   702          679          601          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.452N     P=0.300      P=0.433      P=0.583N   |  P=0.133N     P=0.491N     P=0.549N     P=0.172N   |
|INCIDENTAL TUMOR       |  P=0.137N     P=0.435      P=0.562N     P=0.241N   |  P=0.096N     P=0.449N     P=0.521N     P=0.138N   |
|LOGISTIC REGRESSION    |  P=0.194N     P=0.369      P=0.601N     P=0.331N   |  P=0.100N     P=0.481N     P=0.516N     P=0.146N   |
|COCHRAN-ARMITAGE       |  P=0.118N                                          |  P=0.090N                                          |
|FISHER EXACT           |               P=0.387      P=0.514N     P=0.243N   |               P=0.490N     P=0.490N     P=0.117N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    1/50 (2%)    2/50 (4%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         5.9%        12.5%        16.0%      |   0.0%         0.0%         0.0%         4.8%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          700          721          625       |   ---          ---          ---          609       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.065      P=0.500      P=0.388      P=0.144    |  P=0.044 *      (e)          (e)        P=0.240    |
|INCIDENTAL TUMOR       |  P=0.213      P=0.592      P=0.500      P=0.278    |  P=0.096        (e)          (e)        P=0.328    |
|LOGISTIC REGRESSION    |  P=0.102      P=0.484      P=0.383      P=0.190    |  P=0.041 *      (e)          (e)        P=0.247    |
|COCHRAN-ARMITAGE       |  P=0.176                                           |  P=0.043 *                                         |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.247    |                 (e)          (e)        P=0.253    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE   6
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    3/49 (6%)    3/50 (6%)  |  1/49 (2%)    0/50 (0%)    0/50 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   6.9%         0.0%        14.2%        52.9%      |   3.4%         0.0%         0.0%         9.6%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     2/4 (50%)  |  1/29 (3%)    0/28 (0%)    0/26 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   616          ---          505          660       |   733 (T)      ---          ---          613       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.092      P=0.235N     P=0.381      P=0.254    |  P=0.046 *    P=0.507N     P=0.522N     P=0.246    |
|INCIDENTAL TUMOR       |  P=0.179      P=0.311N     P=0.619      P=0.334    |  P=0.084      P=0.507N     P=0.522N     P=0.317    |
|LOGISTIC REGRESSION    |  P=0.200      P=0.233N     P=0.563      P=0.370    |  P=0.066      P=0.507N     P=0.522N     P=0.314    |
|COCHRAN-ARMITAGE       |  P=0.230                                           |  P=0.066                                           |
|FISHER EXACT           |               P=0.247N     P=0.490      P=0.500    |               P=0.495N     P=0.495N     P=0.316    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    1/49 (2%)    4/50 (8%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        17.9%         6.7%        35.1%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/13 (0%)    1/9 (11%)    0/5 (0%)     1/4 (25%)  |  0/29 (0%)    0/28 (0%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          702          667          540       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.007 **   P=0.173      P=0.433      P=0.021 *  |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.026 *    P=0.245      P=0.500      P=0.046 *  |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.023 *    P=0.200      P=0.452      P=0.052    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.044 *                                         |    (e)                                             |
|FISHER EXACT           |               P=0.247      P=0.495      P=0.059    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE   7
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    4/49 (8%)    6/50 (12%) |  1/49 (2%)    0/50 (0%)    0/50 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   6.9%        17.9%        19.9%        59.3%      |   3.4%         0.0%         0.0%         9.6%      |
|TERMINAL (d)           |  0/13 (0%)    1/9 (11%)    0/5 (0%)     2/4 (50%)  |  1/29 (3%)    0/28 (0%)    0/26 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   616          702          505          540       |   733 (T)      ---          ---          613       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.009 **   P=0.639      P=0.224      P=0.040 *  |  P=0.046 *    P=0.507N     P=0.522N     P=0.246    |
|INCIDENTAL TUMOR       |  P=0.040 *    P=0.644      P=0.442      P=0.088    |  P=0.084      P=0.507N     P=0.522N     P=0.317    |
|LOGISTIC REGRESSION    |  P=0.039 *    P=0.684      P=0.366      P=0.094    |  P=0.066      P=0.507N     P=0.522N     P=0.314    |
|COCHRAN-ARMITAGE       |  P=0.058                                           |  P=0.066                                           |
|FISHER EXACT           |               P=0.691N     P=0.329      P=0.134    |               P=0.495N     P=0.495N     P=0.316    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |  4/49 (8%)    5/50 (10%)   4/50 (8%)    4/50 (8%)  |
|ADJUSTED (b)           |   0.0%        11.1%        12.5%         0.0%      |  12.1%        15.1%        13.4%        14.1%      |
|TERMINAL (d)           |  0/13 (0%)    1/9 (11%)    0/5 (0%)     0/4 (0%)   |  2/29 (7%)    2/28 (7%)    2/26 (8%)    2/21 (10%) |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      721          ---       |   661          671          634          609       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.703      P=0.427      P=0.388        (e)      |  P=0.486      P=0.527      P=0.576      P=0.527    |
|INCIDENTAL TUMOR       |  P=0.658N     P=0.427      P=0.500        (e)      |  P=0.485N     P=0.608      P=0.588      P=0.631N   |
|LOGISTIC REGRESSION    |  P=0.729      P=0.427      P=0.383        (e)      |  P=0.546N     P=0.518      P=0.628      P=0.643    |
|COCHRAN-ARMITAGE       |  P=0.559N                                          |  P=0.510N                                          |
|FISHER EXACT           |               P=0.500      P=0.500        (e)      |               P=0.513      P=0.631N     P=0.631N   |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE   8
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |  4/49 (8%)    5/50 (10%)   4/50 (8%)    4/50 (8%)  |
|ADJUSTED (b)           |   0.0%        11.1%        12.5%         0.0%      |  12.1%        15.1%        13.4%        14.1%      |
|TERMINAL (d)           |  0/13 (0%)    1/9 (11%)    0/5 (0%)     0/4 (0%)   |  2/29 (7%)    2/28 (7%)    2/26 (8%)    2/21 (10%) |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      721          ---       |   661          671          634          609       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.703      P=0.427      P=0.388        (e)      |  P=0.486      P=0.527      P=0.576      P=0.527    |
|INCIDENTAL TUMOR       |  P=0.658N     P=0.427      P=0.500        (e)      |  P=0.485N     P=0.608      P=0.588      P=0.631N   |
|LOGISTIC REGRESSION    |  P=0.729      P=0.427      P=0.383        (e)      |  P=0.546N     P=0.518      P=0.628      P=0.643    |
|COCHRAN-ARMITAGE       |  P=0.559N                                          |  P=0.510N                                          |
|FISHER EXACT           |               P=0.500      P=0.500        (e)      |               P=0.513      P=0.631N     P=0.631N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)  | 24/49 (49%)  32/50 (64%)  36/50 (72%)  36/50 (72%) |
|ADJUSTED (b)           |  10.2%         4.2%         0.0%        25.0%      |  65.4%        86.0%        85.3%        89.7%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     1/4 (25%)  | 17/29 (59%)  23/28 (82%)  20/26 (77%)  17/21 (81%) |
|FIRST INCIDENCE (DAYS) |   658          665          ---          733 (T)   |   366          302          470          433       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.651N     P=0.501N     P=0.326N     P=0.730    |  P<0.001 **   P=0.087      P=0.009 **   P=0.002 ** |
|INCIDENTAL TUMOR       |  P=0.488N     P=0.339N     P=0.235N     P=0.546N   |  P=0.007 **   P=0.097      P=0.012 *    P=0.008 ** |
|LOGISTIC REGRESSION    |  P=0.567N     P=0.513N     P=0.301N     P=0.663N   |  P=0.005 **   P=0.130      P=0.011 *    P=0.009 ** |
|COCHRAN-ARMITAGE       |  P=0.447N                                          |  P=0.025 *                                         |
|FISHER EXACT           |               P=0.500N     P=0.247N     P=0.500N   |               P=0.096      P=0.016 *    P=0.016 *  |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE   9
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)  | 24/49 (49%)  32/50 (64%)  36/50 (72%)  36/50 (72%) |
|ADJUSTED (b)           |  10.2%         4.2%        12.5%        25.0%      |  65.4%        86.0%        85.3%        89.7%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     1/4 (25%)  | 17/29 (59%)  23/28 (82%)  20/26 (77%)  17/21 (81%) |
|FIRST INCIDENCE (DAYS) |   658          665          721          733 (T)   |   366          302          470          433       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.602      P=0.501N     P=0.649N     P=0.730    |  P<0.001 **   P=0.087      P=0.009 **   P=0.002 ** |
|INCIDENTAL TUMOR       |  P=0.483N     P=0.339N     P=0.500N     P=0.546N   |  P=0.007 **   P=0.097      P=0.012 *    P=0.008 ** |
|LOGISTIC REGRESSION    |  P=0.612N     P=0.513N     P=0.634N     P=0.663N   |  P=0.005 **   P=0.130      P=0.011 *    P=0.009 ** |
|COCHRAN-ARMITAGE       |  P=0.457N                                          |  P=0.025 *                                         |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.096      P=0.016 *    P=0.016 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    1/50 (2%)    1/50 (2%)  | 28/49 (57%)  34/50 (68%)  36/50 (72%)  36/50 (72%) |
|ADJUSTED (b)           |  10.2%        14.8%        12.5%        25.0%      |  72.7%        89.1%        85.3%        89.7%      |
|TERMINAL (d)           |  0/13 (0%)    1/9 (11%)    0/5 (0%)     1/4 (25%)  | 19/29 (66%)  24/28 (86%)  20/26 (77%)  17/21 (81%) |
|FIRST INCIDENCE (DAYS) |   658          665          721          733 (T)   |   366          302          470          433       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.631      P=0.659      P=0.649N     P=0.730    |  P=0.006 **   P=0.177      P=0.045 *    P=0.011 *  |
|INCIDENTAL TUMOR       |  P=0.448N     P=0.604N     P=0.500N     P=0.546N   |  P=0.041 *    P=0.213      P=0.060      P=0.050    |
|LOGISTIC REGRESSION    |  P=0.549N     P=0.677      P=0.634N     P=0.663N   |  P=0.039 *    P=0.235      P=0.068      P=0.059    |
|COCHRAN-ARMITAGE       |  P=0.363N                                          |  P=0.115                                           |
|FISHER EXACT           |               P=0.691N     P=0.500N     P=0.500N   |               P=0.182      P=0.091      P=0.091    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  10
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    4/50 (8%)   10/50 (20%) |  1/49 (2%)    2/50 (4%)    2/50 (4%)    7/50 (14%) |
|ADJUSTED (b)           |   0.0%        13.8%        25.4%        71.7%      |   3.0%         6.2%         7.7%        29.5%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     2/4 (50%)  |  0/29 (0%)    1/28 (4%)    2/26 (8%)    5/21 (24%) |
|FIRST INCIDENCE (DAYS) |   ---          701          620          539       |   687          681          733 (T)      660       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.198      P=0.029 *    P<0.001 ** |  P=0.002 **   P=0.516      P=0.464      P=0.013 *  |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.343      P=0.070      P<0.001 ** |  P=0.004 **   P=0.574      P=0.449      P=0.024 *  |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.217      P=0.040 *    P<0.001 ** |  P=0.003 **   P=0.508      P=0.469      P=0.020 *  |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P=0.007 **                                        |
|FISHER EXACT           |               P=0.247      P=0.059      P<0.001 ** |               P=0.508      P=0.508      P=0.032 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |  0/49 (0%)    1/50 (2%)    3/50 (6%)    4/50 (8%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.0%        11.3%      |   0.0%         3.2%         9.8%        14.8%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    2/26 (8%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          609          649       |   ---          721          588          671       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.051        (e)        P=0.439      P=0.185    |  P=0.017 *    P=0.507      P=0.109      P=0.047 *  |
|INCIDENTAL TUMOR       |  P=0.097        (e)        P=0.521      P=0.316    |  P=0.042 *    P=0.567      P=0.127      P=0.082    |
|LOGISTIC REGRESSION    |  P=0.067        (e)        P=0.521      P=0.200    |  P=0.028 *    P=0.510      P=0.121      P=0.055    |
|COCHRAN-ARMITAGE       |  P=0.077                                           |  P=0.034 *                                         |
|FISHER EXACT           |                 (e)        P=0.500      P=0.247    |               P=0.505      P=0.125      P=0.061    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  11
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    5/50 (10%)  12/50 (24%) |  1/49 (2%)    3/50 (6%)    5/50 (10%)  11/50 (22%) |
|ADJUSTED (b)           |   0.0%        13.8%        28.4%        74.9%      |   3.0%         9.2%        17.4%        40.8%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     2/4 (50%)  |  0/29 (0%)    1/28 (4%)    4/26 (15%)   6/21 (29%) |
|FIRST INCIDENCE (DAYS) |   ---          701          609          539       |   687          681          588          660       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.198      P=0.013 *    P<0.001 ** |  P<0.001 **   P=0.324      P=0.086      P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.343      P=0.039 *    P<0.001 ** |  P<0.001 **   P=0.393      P=0.093      P=0.002 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.217      P=0.022 *    P<0.001 ** |  P<0.001 **   P=0.315      P=0.093      P=0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.247      P=0.028 *    P<0.001 ** |               P=0.316      P=0.107      P=0.002 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    1/50 (2%)    4/50 (8%)  |  1/49 (2%)    1/50 (2%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%        13.8%         4.3%        15.5%      |   3.0%         2.7%         3.8%         4.8%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    1/26 (4%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          701          620          540       |   687          681          733 (T)      733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.019 *    P=0.198      P=0.447      P=0.048 *  |  P=0.577      P=0.741N     P=0.738      P=0.701    |
|INCIDENTAL TUMOR       |  P=0.062      P=0.343      P=0.521      P=0.099    |  P=0.642      P=0.688N     P=0.723      P=0.762N   |
|LOGISTIC REGRESSION    |  P=0.034 *    P=0.217      P=0.508      P=0.065    |  P=0.632      P=0.758N     P=0.749      P=0.746    |
|COCHRAN-ARMITAGE       |  P=0.043 *                                         |  P=0.651N                                          |
|FISHER EXACT           |               P=0.247      P=0.500      P=0.059    |               P=0.747N     P=0.747N     P=0.747N   |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  12
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 40/50 (80%)  40/49 (82%)  43/50 (86%)  39/49 (80%) | 36/48 (75%)  44/50 (88%)  44/50 (88%)  36/50 (72%) |
|ADJUSTED (b)           |  92.2%        97.0%       100.0%        96.3%      |  89.8%        97.7%        93.6%        83.3%      |
|TERMINAL (d)           | 10/13 (77%)   8/9 (89%)    5/5 (100%)   3/4 (75%)  | 24/28 (86%)  27/28 (96%)  23/26 (88%)  14/21 (67%) |
|FIRST INCIDENCE (DAYS) |   469          357          460          470       |   553          352          450          463       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.018 *    P=0.340      P=0.009 **   P=0.036 *  |  P=0.198      P=0.150      P=0.051      P=0.171    |
|INCIDENTAL TUMOR       |  P=0.491      P=0.590      P=0.231      P=0.507    |  P=0.214N     P=0.073      P=0.027 *    P=0.532N   |
|LOGISTIC REGRESSION    |  P=0.508      P=0.526      P=0.263      P=0.466    |  P=0.193N     P=0.061      P=0.043 *    P=0.549N   |
|COCHRAN-ARMITAGE       |  P=0.506N                                          |  P=0.160N                                          |
|FISHER EXACT           |               P=0.520      P=0.298      P=0.579N   |               P=0.080      P=0.080      P=0.458N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    3/50 (6%)    1/50 (2%)  |                                                    |
|ADJUSTED (b)           |   0.0%        11.1%        35.0%         5.9%      |                                                    |
|TERMINAL (d)           |  0/13 (0%)    1/9 (11%)    1/5 (20%)    0/4 (0%)   |                                                    |
|FIRST INCIDENCE (DAYS) |   ---          733 (T)      679          660       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.182      P=0.427      P=0.038 *    P=0.458    |                                                    |
|INCIDENTAL TUMOR       |  P=0.337      P=0.427      P=0.069      P=0.569    |                                                    |
|LOGISTIC REGRESSION    |  P=0.263      P=0.427      P=0.045 *    P=0.465    |                                                    |
|COCHRAN-ARMITAGE       |  P=0.448                                           |                                                    |
|FISHER EXACT           |               P=0.500      P=0.121      P=0.500    |                                                    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  13
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |  0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         8.7%         0.0%         0.0%      |   0.0%         0.0%         3.8%         0.0%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    1/26 (4%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          609          ---          ---       |   ---          ---          733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.475N     P=0.236        (e)          (e)      |  P=0.752        (e)        P=0.478        (e)      |
|INCIDENTAL TUMOR       |  P=0.357N     P=0.250        (e)          (e)      |  P=0.752        (e)        P=0.478        (e)      |
|LOGISTIC REGRESSION    |  P=0.412N     P=0.234        (e)          (e)      |  P=0.752        (e)        P=0.478        (e)      |
|COCHRAN-ARMITAGE       |  P=0.382N                                          |  P=0.780                                           |
|FISHER EXACT           |               P=0.247        (e)          (e)      |                 (e)        P=0.505        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign,                                                       |
|     malignant or NOS), or Trichoepithelioma                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |  0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   3.6%         8.7%         0.0%         0.0%      |   0.0%         0.0%         3.8%         0.0%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    1/26 (4%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   637          609          ---          ---       |   ---          ---          733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.277N     P=0.505      P=0.577N     P=0.557N   |  P=0.752        (e)        P=0.478        (e)      |
|INCIDENTAL TUMOR       |  P=0.180N     P=0.477      P=0.479N     P=0.500N   |  P=0.752        (e)        P=0.478        (e)      |
|LOGISTIC REGRESSION    |  P=0.218N     P=0.497      P=0.511N     P=0.510N   |  P=0.752        (e)        P=0.478        (e)      |
|COCHRAN-ARMITAGE       |  P=0.200N                                          |  P=0.780                                           |
|FISHER EXACT           |               P=0.500      P=0.500N     P=0.500N   |                 (e)        P=0.505        (e)      |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  14
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal                                                       |
|     Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    5/50 (10%)   3/50 (6%)    5/50 (10%) |  0/49 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |  14.9%        20.8%        12.8%        43.5%      |   0.0%         0.0%         3.8%         4.8%      |
|TERMINAL (d)           |  1/13 (8%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    1/26 (4%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   637          609          540          625       |   ---          ---          733 (T)      733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.134      P=0.361      P=0.457      P=0.116    |  P=0.209        (e)        P=0.478      P=0.436    |
|INCIDENTAL TUMOR       |  P=0.423      P=0.387      P=0.658      P=0.399    |  P=0.209        (e)        P=0.478      P=0.436    |
|LOGISTIC REGRESSION    |  P=0.273      P=0.341      P=0.644      P=0.201    |  P=0.209        (e)        P=0.478      P=0.436    |
|COCHRAN-ARMITAGE       |  P=0.376                                           |  P=0.277                                           |
|FISHER EXACT           |               P=0.357      P=0.661N     P=0.357    |                 (e)        P=0.505      P=0.505    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)  |  0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%        15.3%         0.0%         3.2%      |   0.0%         0.0%         3.8%         0.0%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    1/26 (4%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          700          ---          603       |   ---          ---          733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.416      P=0.211        (e)        P=0.476    |  P=0.752        (e)        P=0.478        (e)      |
|INCIDENTAL TUMOR       |  P=0.626      P=0.343        (e)        P=0.500    |  P=0.752        (e)        P=0.478        (e)      |
|LOGISTIC REGRESSION    |  P=0.514      P=0.204        (e)        P=0.524    |  P=0.752        (e)        P=0.478        (e)      |
|COCHRAN-ARMITAGE       |  P=0.591                                           |  P=0.780                                           |
|FISHER EXACT           |               P=0.247        (e)        P=0.500    |                 (e)        P=0.505        (e)      |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  15
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    1/50 (2%)    2/50 (4%)  |  2/49 (4%)    0/50 (0%)    2/50 (4%)    0/50 (0%)  |
|ADJUSTED (b)           |  10.1%        15.3%        12.5%         5.2%      |   6.9%         0.0%         7.7%         0.0%      |
|TERMINAL (d)           |  1/13 (8%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  2/29 (7%)    0/28 (0%)    2/26 (8%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   576          700          721          307       |   733 (T)      ---          733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.390      P=0.635      P=0.700N     P=0.574    |  P=0.347N     P=0.246N     P=0.656      P=0.311N   |
|INCIDENTAL TUMOR       |  P=0.502N     P=0.677N     P=0.593N     P=0.627N   |  P=0.347N     P=0.246N     P=0.656      P=0.311N   |
|LOGISTIC REGRESSION    |  P=0.556N     P=0.679      P=0.599N     P=0.561N   |  P=0.347N     P=0.246N     P=0.656      P=0.311N   |
|COCHRAN-ARMITAGE       |  P=0.616N                                          |  P=0.267N                                          |
|FISHER EXACT           |               P=0.691N     P=0.500N     P=0.691N   |               P=0.242N     P=0.684N     P=0.242N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  2/49 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.7%         0.0%         0.0%         0.0%      |   6.9%         0.0%         3.8%         0.0%      |
|TERMINAL (d)           |  1/13 (8%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  2/29 (7%)    0/28 (0%)    1/26 (4%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      ---          ---          ---       |   733 (T)      ---          733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.574N     P=0.573N     P=0.690N     P=0.734N   |  P=0.294N     P=0.246N     P=0.538N     P=0.311N   |
|INCIDENTAL TUMOR       |  P=0.574N     P=0.573N     P=0.690N     P=0.734N   |  P=0.294N     P=0.246N     P=0.538N     P=0.311N   |
|LOGISTIC REGRESSION    |  P=0.574N     P=0.573N     P=0.690N     P=0.734N   |  P=0.294N     P=0.246N     P=0.538N     P=0.311N   |
|COCHRAN-ARMITAGE       |  P=0.406N                                          |  P=0.233N                                          |
|FISHER EXACT           |               P=0.500N     P=0.500N     P=0.500N   |               P=0.242N     P=0.492N     P=0.242N   |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  16
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |  2/49 (4%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |  10.1%         0.0%        12.5%         2.0%      |   6.9%         0.0%         3.8%         0.0%      |
|TERMINAL (d)           |  1/13 (8%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  2/29 (7%)    0/28 (0%)    1/26 (4%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   576          ---          721          307       |   733 (T)      ---          733 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.594      P=0.280N     P=0.700N     P=0.637N   |  P=0.294N     P=0.246N     P=0.538N     P=0.311N   |
|INCIDENTAL TUMOR       |  P=0.457N     P=0.319N     P=0.593N     P=0.360N   |  P=0.294N     P=0.246N     P=0.538N     P=0.311N   |
|LOGISTIC REGRESSION    |  P=0.375N     P=0.241N     P=0.599N     P=0.332N   |  P=0.294N     P=0.246N     P=0.538N     P=0.311N   |
|COCHRAN-ARMITAGE       |  P=0.574N                                          |  P=0.233N                                          |
|FISHER EXACT           |               P=0.247N     P=0.500N     P=0.500N   |               P=0.242N     P=0.492N     P=0.242N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    4/50 (8%)    2/50 (4%)    4/50 (8%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  11.7%        15.6%        10.1%        34.1%      |   0.0%         0.0%         0.0%         4.8%      |
|TERMINAL (d)           |  1/13 (8%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   657          609          540          625       |   ---          ---          ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.145      P=0.336      P=0.514      P=0.122    |  P=0.162        (e)          (e)        P=0.436    |
|INCIDENTAL TUMOR       |  P=0.388      P=0.362      P=0.673      P=0.356    |  P=0.162        (e)          (e)        P=0.436    |
|LOGISTIC REGRESSION    |  P=0.265      P=0.324      P=0.646      P=0.195    |  P=0.162        (e)          (e)        P=0.436    |
|COCHRAN-ARMITAGE       |  P=0.359                                           |  P=0.208                                           |
|FISHER EXACT           |               P=0.339      P=0.691N     P=0.339    |                 (e)          (e)        P=0.505    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  17
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Lipoma                                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  10.4%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.0%         4.8%      |
|TERMINAL (d)           |  1/13 (8%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   613          ---          ---          ---       |   ---          ---          ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.277N     P=0.287N     P=0.392N     P=0.393N   |  P=0.162        (e)          (e)        P=0.436    |
|INCIDENTAL TUMOR       |  P=0.244N     P=0.319N     P=0.325N     P=0.360N   |  P=0.162        (e)          (e)        P=0.436    |
|LOGISTIC REGRESSION    |  P=0.217N     P=0.244N     P=0.292N     P=0.290N   |  P=0.162        (e)          (e)        P=0.436    |
|COCHRAN-ARMITAGE       |  P=0.185N                                          |  P=0.208                                           |
|FISHER EXACT           |               P=0.247N     P=0.247N     P=0.247N   |                 (e)          (e)        P=0.505    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    4/50 (8%)    3/50 (6%)    5/50 (10%) |  0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  11.7%        15.6%        12.8%        43.5%      |   0.0%         0.0%         0.0%         4.8%      |
|TERMINAL (d)           |  1/13 (8%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   657          609          540          625       |   ---          ---          ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.063      P=0.336      P=0.312      P=0.051    |  P=0.162        (e)          (e)        P=0.436    |
|INCIDENTAL TUMOR       |  P=0.245      P=0.362      P=0.483      P=0.246    |  P=0.162        (e)          (e)        P=0.436    |
|LOGISTIC REGRESSION    |  P=0.145      P=0.324      P=0.477      P=0.094    |  P=0.162        (e)          (e)        P=0.436    |
|COCHRAN-ARMITAGE       |  P=0.215                                           |  P=0.208                                           |
|FISHER EXACT           |               P=0.339      P=0.500      P=0.218    |                 (e)          (e)        P=0.505    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  18
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    4/50 (8%)    3/50 (6%)    5/50 (10%) |  0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  11.7%        15.6%        12.8%        43.5%      |   0.0%         0.0%         0.0%         4.8%      |
|TERMINAL (d)           |  1/13 (8%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   657          609          540          625       |   ---          ---          ---          733 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.063      P=0.336      P=0.312      P=0.051    |  P=0.162        (e)          (e)        P=0.436    |
|INCIDENTAL TUMOR       |  P=0.245      P=0.362      P=0.483      P=0.246    |  P=0.162        (e)          (e)        P=0.436    |
|LOGISTIC REGRESSION    |  P=0.145      P=0.324      P=0.477      P=0.094    |  P=0.162        (e)          (e)        P=0.436    |
|COCHRAN-ARMITAGE       |  P=0.215                                           |  P=0.208                                           |
|FISHER EXACT           |               P=0.339      P=0.500      P=0.218    |                 (e)          (e)        P=0.505    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Sebaceous Gland                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   7.7%        13.1%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/13 (8%)    1/9 (11%)    0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      541          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.347N     P=0.415      P=0.690N     P=0.734N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.315N     P=0.430      P=0.690N     P=0.734N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.240N     P=0.490      P=0.690N     P=0.734N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.200N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.500N     P=0.500N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  19
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 34/50 (68%)  34/50 (68%)  28/50 (56%)  29/50 (58%) |                                                    |
|ADJUSTED (b)           |  90.7%       100.0%        93.7%       100.0%      |                                                    |
|TERMINAL (d)           | 10/13 (77%)   9/9 (100%)   4/5 (80%)    4/4 (100%) |                                                    |
|FIRST INCIDENCE (DAYS) |   469          525          460          463       |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.061      P=0.289      P=0.154      P=0.077    |                                                    |
|INCIDENTAL TUMOR       |  P=0.363N     P=0.366      P=0.257N     P=0.446N   |                                                    |
|LOGISTIC REGRESSION    |  P=0.348N     P=0.529      P=0.238N     P=0.448N   |                                                    |
|COCHRAN-ARMITAGE       |  P=0.140N                                          |                                                    |
|FISHER EXACT           |               P=0.585N     P=0.151N     P=0.204N   |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Thymoma Benign                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/42 (2%)    0/42 (0%)    0/46 (0%)    2/48 (4%)  |  0/43 (0%)    0/41 (0%)    0/48 (0%)    0/46 (0%)  |
|ADJUSTED (b)           |  10.0%         0.0%         0.0%        12.3%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/10 (10%)   0/7 (0%)     0/5 (0%)     0/4 (0%)   |  0/26 (0%)    0/22 (0%)    0/25 (0%)    0/19 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      ---          ---          649       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.112      P=0.571N     P=0.638N     P=0.325    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.175      P=0.571N     P=0.638N     P=0.471    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.165      P=0.571N     P=0.638N     P=0.418    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.240                                           |    (e)                                             |
|FISHER EXACT           |               P=0.500N     P=0.477N     P=0.550    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  20
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Thymoma: Benign, Malignant, NOS                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/42 (2%)    0/42 (0%)    0/46 (0%)    2/48 (4%)  |  0/43 (0%)    0/41 (0%)    1/48 (2%)    0/46 (0%)  |
|ADJUSTED (b)           |  10.0%         0.0%         0.0%        12.3%      |   0.0%         0.0%         2.3%         0.0%      |
|TERMINAL (d)           |  1/10 (10%)   0/7 (0%)     0/5 (0%)     0/4 (0%)   |  0/26 (0%)    0/22 (0%)    0/25 (0%)    0/19 (0%)  |
|FIRST INCIDENCE (DAYS) |   733 (T)      ---          ---          649       |   ---          ---          585          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.112      P=0.571N     P=0.638N     P=0.325    |  P=0.777        (e)        P=0.500        (e)      |
|INCIDENTAL TUMOR       |  P=0.175      P=0.571N     P=0.638N     P=0.471    |  P=0.677N       (e)        P=0.571        (e)      |
|LOGISTIC REGRESSION    |  P=0.165      P=0.571N     P=0.638N     P=0.418    |  P=0.785N       (e)        P=0.578        (e)      |
|COCHRAN-ARMITAGE       |  P=0.240                                           |  P=0.783N                                          |
|FISHER EXACT           |               P=0.500N     P=0.477N     P=0.550    |                 (e)        P=0.527        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    6/50 (12%)   4/49 (8%)    7/50 (14%) |  7/49 (14%)   3/50 (6%)    5/50 (10%)   5/50 (10%) |
|ADJUSTED (b)           |  18.0%        21.6%        44.0%        55.3%      |  20.3%        10.7%        16.2%        19.1%      |
|TERMINAL (d)           |  2/13 (15%)   0/9 (0%)     1/5 (20%)    1/4 (25%)  |  3/29 (10%)   3/28 (11%)   3/26 (12%)   3/21 (14%) |
|FIRST INCIDENCE (DAYS) |   616          541          609          549       |   622          733 (T)      590          463       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.024 *    P=0.227      P=0.172      P=0.019 *  |  P=0.481      P=0.162N     P=0.460N     P=0.538N   |
|INCIDENTAL TUMOR       |  P=0.140      P=0.274      P=0.300      P=0.078    |  P=0.527N     P=0.154N     P=0.433N     P=0.367N   |
|LOGISTIC REGRESSION    |  P=0.092      P=0.233      P=0.287      P=0.078    |  P=0.516N     P=0.145N     P=0.391N     P=0.380N   |
|COCHRAN-ARMITAGE       |  P=0.183                                           |  P=0.485N                                          |
|FISHER EXACT           |               P=0.243      P=0.489      P=0.159    |               P=0.151N     P=0.365N     P=0.365N   |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  21
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/50 (4%)    2/50 (4%)    2/49 (4%)    0/50 (0%)  |  1/49 (2%)    2/50 (4%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   9.9%        10.8%        11.8%         0.0%      |   3.4%         7.1%         2.7%         0.0%      |
|TERMINAL (d)           |  1/13 (8%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  1/29 (3%)    2/28 (7%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   571          679          652          ---       |   733 (T)      733 (T)      608          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.312N     P=0.648      P=0.520      P=0.378N   |  P=0.289N     P=0.488      P=0.737      P=0.564N   |
|INCIDENTAL TUMOR       |  P=0.166N     P=0.677N     P=0.619      P=0.360N   |  P=0.247N     P=0.488      P=0.738N     P=0.564N   |
|LOGISTIC REGRESSION    |  P=0.206N     P=0.685      P=0.636      P=0.262N   |  P=0.248N     P=0.488      P=0.755N     P=0.564N   |
|COCHRAN-ARMITAGE       |  P=0.158N                                          |  P=0.233N                                          |
|FISHER EXACT           |               P=0.691N     P=0.684      P=0.247N   |               P=0.508      P=0.747N     P=0.495N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/50 (10%)   7/50 (14%)   6/49 (12%)   7/50 (14%) |  8/49 (16%)   5/50 (10%)   6/50 (12%)   5/50 (10%) |
|ADJUSTED (b)           |  27.3%        25.8%        50.6%        55.3%      |  23.4%        17.9%        18.4%        19.1%      |
|TERMINAL (d)           |  3/13 (23%)   0/9 (0%)     1/5 (20%)    1/4 (25%)  |  4/29 (14%)   5/28 (18%)   3/26 (12%)   3/21 (14%) |
|FIRST INCIDENCE (DAYS) |   571          541          609          549       |   622          733 (T)      590          463       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.076      P=0.333      P=0.148      P=0.070    |  P=0.493N     P=0.282N     P=0.474N     P=0.440N   |
|INCIDENTAL TUMOR       |  P=0.326      P=0.398      P=0.285      P=0.199    |  P=0.345N     P=0.275N     P=0.426N     P=0.281N   |
|LOGISTIC REGRESSION    |  P=0.240      P=0.366      P=0.285      P=0.240    |  P=0.333N     P=0.249N     P=0.392N     P=0.282N   |
|COCHRAN-ARMITAGE       |  P=0.396                                           |  P=0.302N                                          |
|FISHER EXACT           |               P=0.380      P=0.486      P=0.380    |               P=0.264N     P=0.371N     P=0.264N   |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  22
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    2/49 (4%)    4/50 (8%)  |  1/49 (2%)    1/50 (2%)    0/50 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   0.0%        13.5%        22.5%        33.1%      |   3.4%         3.2%         0.0%        12.0%      |
|TERMINAL (d)           |  0/13 (0%)    1/9 (11%)    1/5 (20%)    1/4 (25%)  |  1/29 (3%)    0/28 (0%)    0/26 (0%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          597          569          307       |   733 (T)      721          ---          705       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.013 *    P=0.202      P=0.117      P=0.027 *  |  P=0.090      P=0.760      P=0.522N     P=0.229    |
|INCIDENTAL TUMOR       |  P=0.043 *    P=0.168      P=0.145      P=0.075    |  P=0.144      P=0.728N     P=0.522N     P=0.306    |
|LOGISTIC REGRESSION    |  P=0.063      P=0.232      P=0.201      P=0.089    |  P=0.104      P=0.753N     P=0.522N     P=0.252    |
|COCHRAN-ARMITAGE       |  P=0.054                                           |  P=0.142                                           |
|FISHER EXACT           |               P=0.247      P=0.242      P=0.059    |               P=0.747N     P=0.495N     P=0.316    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/49 (4%)    1/50 (2%)  |  0/49 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         9.1%         4.8%      |   0.0%         0.0%         3.8%         5.5%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    1/26 (4%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          622          646       |   ---          ---          733 (T)      617       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.260        (e)        P=0.172      P=0.465    |  P=0.059        (e)        P=0.478      P=0.222    |
|INCIDENTAL TUMOR       |  P=0.342        (e)        P=0.249      P=0.569    |  P=0.104        (e)        P=0.478      P=0.324    |
|LOGISTIC REGRESSION    |  P=0.299        (e)        P=0.234      P=0.480    |  P=0.080        (e)        P=0.478      P=0.251    |
|COCHRAN-ARMITAGE       |  P=0.307                                           |  P=0.078                                           |
|FISHER EXACT           |                 (e)        P=0.242      P=0.500    |                 (e)        P=0.505      P=0.253    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  23
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    4/49 (8%)    5/50 (10%) |  1/49 (2%)    1/50 (2%)    1/50 (2%)    5/50 (10%) |
|ADJUSTED (b)           |   0.0%        13.5%        29.5%        36.3%      |   3.4%         3.2%         3.8%        16.8%      |
|TERMINAL (d)           |  0/13 (0%)    1/9 (11%)    1/5 (20%)    1/4 (25%)  |  1/29 (3%)    0/28 (0%)    1/26 (4%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          597          569          307       |   733 (T)      721          733 (T)      617       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.007 **   P=0.202      P=0.021 *    P=0.014 *  |  P=0.010 *    P=0.760      P=0.738      P=0.072    |
|INCIDENTAL TUMOR       |  P=0.027 *    P=0.168      P=0.039 *    P=0.046 *  |  P=0.028 *    P=0.728N     P=0.738      P=0.133    |
|LOGISTIC REGRESSION    |  P=0.029 *    P=0.232      P=0.050      P=0.044 *  |  P=0.017 *    P=0.753N     P=0.738      P=0.098    |
|COCHRAN-ARMITAGE       |  P=0.029 *                                         |  P=0.022 *                                         |
|FISHER EXACT           |               P=0.247      P=0.056      P=0.028 *  |               P=0.747N     P=0.747N     P=0.107    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    2/50 (4%)  |  0/49 (0%)    1/50 (2%)    2/50 (4%)    4/50 (8%)  |
|ADJUSTED (b)           |   0.0%         0.0%         4.0%        11.3%      |   0.0%         3.2%         6.1%        14.8%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    1/26 (4%)    1/21 (5%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          609          649       |   ---          721          588          671       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.051        (e)        P=0.439      P=0.185    |  P=0.014 *    P=0.507      P=0.225      P=0.047 *  |
|INCIDENTAL TUMOR       |  P=0.097        (e)        P=0.521      P=0.316    |  P=0.038 *    P=0.567      P=0.262      P=0.082    |
|LOGISTIC REGRESSION    |  P=0.067        (e)        P=0.521      P=0.200    |  P=0.023 *    P=0.510      P=0.248      P=0.055    |
|COCHRAN-ARMITAGE       |  P=0.077                                           |  P=0.026 *                                         |
|FISHER EXACT           |                 (e)        P=0.500      P=0.247    |               P=0.505      P=0.253      P=0.061    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  24
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    4/50 (8%)    8/50 (16%) |  0/49 (0%)    3/50 (6%)    3/50 (6%)   11/50 (22%) |
|ADJUSTED (b)           |   0.0%         0.0%        25.2%        70.2%      |   0.0%         9.2%         9.8%        40.8%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     2/4 (50%)  |  0/29 (0%)    1/28 (4%)    2/26 (8%)    6/21 (29%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          609          539       |   ---          681          588          660       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **     (e)        P=0.028 *    P<0.001 ** |  P<0.001 **   P=0.131      P=0.109      P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **     (e)        P=0.070      P=0.003 ** |  P<0.001 **   P=0.160      P=0.127      P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **     (e)        P=0.041 *    P=0.001 ** |  P<0.001 **   P=0.126      P=0.121      P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |                 (e)        P=0.059      P=0.003 ** |               P=0.125      P=0.125      P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Tongue                                                                                                                           |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    3/50 (6%)    6/50 (12%) |  0/49 (0%)    2/50 (4%)    1/50 (2%)    7/50 (14%) |
|ADJUSTED (b)           |   0.0%         0.0%        22.0%        66.4%      |   0.0%         6.2%         3.8%        29.5%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     2/4 (50%)  |  0/29 (0%)    1/28 (4%)    1/26 (4%)    5/21 (24%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          622          539       |   ---          681          733 (T)      660       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **     (e)        P=0.063      P<0.001 ** |  P<0.001 **   P=0.248      P=0.478      P=0.003 ** |
|INCIDENTAL TUMOR       |  P<0.001 **     (e)        P=0.127      P=0.008 ** |  P<0.001 **   P=0.272      P=0.478      P=0.005 ** |
|LOGISTIC REGRESSION    |  P<0.001 **     (e)        P=0.077      P=0.005 ** |  P<0.001 **   P=0.244      P=0.478      P=0.005 ** |
|COCHRAN-ARMITAGE       |  P=0.001 **                                        |  P=0.001 **                                        |
|FISHER EXACT           |                 (e)        P=0.121      P=0.013 *  |               P=0.253      P=0.505      P=0.007 ** |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  25
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/49 (0%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%        12.5%         0.0%      |   0.0%         0.0%         0.0%         4.9%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          721          ---       |   ---          ---          ---          591       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.693        (e)        P=0.388        (e)      |  P=0.041 *      (e)          (e)        P=0.234    |
|INCIDENTAL TUMOR       |  P=0.779N       (e)        P=0.500        (e)      |  P=0.096        (e)          (e)        P=0.328    |
|LOGISTIC REGRESSION    |  P=0.709        (e)        P=0.383        (e)      |  P=0.041 *      (e)          (e)        P=0.246    |
|COCHRAN-ARMITAGE       |  P=0.776                                           |  P=0.043 *                                         |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |                 (e)          (e)        P=0.253    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Carcinoma or Papilloma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    1/49 (2%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%        12.5%         3.3%      |   0.0%         0.0%         0.0%         4.9%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          721          608       |   ---          ---          ---          591       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.178        (e)        P=0.388      P=0.475    |  P=0.041 *      (e)          (e)        P=0.234    |
|INCIDENTAL TUMOR       |  P=0.297        (e)        P=0.500      P=0.500    |  P=0.096        (e)          (e)        P=0.328    |
|LOGISTIC REGRESSION    |  P=0.227        (e)        P=0.383      P=0.515    |  P=0.041 *      (e)          (e)        P=0.246    |
|COCHRAN-ARMITAGE       |  P=0.270                                           |  P=0.043 *                                         |
|FISHER EXACT           |                 (e)        P=0.500      P=0.495    |                 (e)          (e)        P=0.253    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  26
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  6/49 (12%)   4/50 (8%)    6/50 (12%)  10/50 (20%) |
|ADJUSTED (b)           |                                                    |  19.3%        11.9%        20.5%        31.2%      |
|TERMINAL (d)           |                                                    |  5/29 (17%)   2/28 (7%)    4/26 (15%)   3/21 (14%) |
|FIRST INCIDENCE (DAYS) |                                                    |   644          565          608          572       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.029 *    P=0.377N     P=0.540      P=0.112    |
|INCIDENTAL TUMOR       |                                                    |  P=0.087      P=0.450N     P=0.587      P=0.220    |
|LOGISTIC REGRESSION    |                                                    |  P=0.067      P=0.352N     P=0.571      P=0.199    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.079                                           |
|FISHER EXACT           |                                                    |               P=0.357N     P=0.606N     P=0.220    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.1%        10.0%         0.0%         5.5%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   525          730          ---          540       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.250      P=0.729      P=0.531N     P=0.469    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.393      P=0.694N     P=0.377N     P=0.559    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.383      P=0.759N     P=0.370N     P=0.634    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.345                                           |    (e)                                             |
|FISHER EXACT           |               P=0.753N     P=0.500N     P=0.500    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  27
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         0.0%         2.2%         0.0%      |   0.0%         0.0%         0.0%         7.1%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          506          ---       |   ---          ---          ---          648       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.771        (e)        P=0.487        (e)      |  P=0.030 *      (e)          (e)        P=0.200    |
|INCIDENTAL TUMOR       |  P=0.783N       (e)        P=0.623        (e)      |  P=0.064        (e)          (e)        P=0.312    |
|LOGISTIC REGRESSION    |  P=0.702N       (e)        P=0.658        (e)      |  P=0.042 *      (e)          (e)        P=0.238    |
|COCHRAN-ARMITAGE       |  P=0.778                                           |  P=0.043 *                                         |
|FISHER EXACT           |                 (e)        P=0.500        (e)      |                 (e)          (e)        P=0.253    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |
|ADJUSTED (b)           |   0.0%         9.1%         2.2%         0.0%      |   0.0%         0.0%         0.0%         7.1%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          707          506          ---       |   ---          ---          ---          648       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.660N     P=0.425      P=0.487        (e)      |  P=0.030 *      (e)          (e)        P=0.200    |
|INCIDENTAL TUMOR       |  P=0.521N     P=0.592      P=0.623        (e)      |  P=0.064        (e)          (e)        P=0.312    |
|LOGISTIC REGRESSION    |  P=0.540N     P=0.479      P=0.658        (e)      |  P=0.042 *      (e)          (e)        P=0.238    |
|COCHRAN-ARMITAGE       |  P=0.559N                                          |  P=0.043 *                                         |
|FISHER EXACT           |               P=0.500      P=0.500        (e)      |                 (e)          (e)        P=0.253    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  28
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)  |  0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         6.0%      |   0.0%         0.0%         0.0%         3.2%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          530       |   ---          ---          ---          667       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.038 *      (e)          (e)        P=0.217    |  P=0.184        (e)          (e)        P=0.482    |
|INCIDENTAL TUMOR       |  P=0.048 *      (e)          (e)        P=0.267    |  P=0.245        (e)          (e)        P=0.567    |
|LOGISTIC REGRESSION    |  P=0.056        (e)          (e)        P=0.289    |  P=0.210        (e)          (e)        P=0.508    |
|COCHRAN-ARMITAGE       |  P=0.043 *                                         |  P=0.208                                           |
|FISHER EXACT           |                 (e)          (e)        P=0.247    |                 (e)          (e)        P=0.505    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/50 (66%)  34/50 (68%)  29/50 (58%)  27/50 (54%) | 18/49 (37%)  18/50 (36%)  20/50 (40%)  26/50 (52%) |
|ADJUSTED (b)           |  86.3%        90.8%        94.1%        95.6%      |  43.4%        43.4%        51.4%        83.0%      |
|TERMINAL (d)           |  8/13 (62%)   6/9 (67%)    4/5 (80%)    3/4 (75%)  |  8/29 (28%)   6/28 (21%)   8/26 (31%)  16/21 (76%) |
|FIRST INCIDENCE (DAYS) |   489          525          506          540       |   366          485          540          525       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.121      P=0.296      P=0.099      P=0.116    |  P=0.010 **   P=0.541N     P=0.321      P=0.020 *  |
|INCIDENTAL TUMOR       |  P=0.136N     P=0.489      P=0.407N     P=0.197N   |  P=0.073      P=0.493      P=0.522      P=0.074    |
|LOGISTIC REGRESSION    |  P=0.169N     P=0.461      P=0.470N     P=0.408N   |  P=0.044 *    P=0.536      P=0.504      P=0.088    |
|COCHRAN-ARMITAGE       |  P=0.082N                                          |  P=0.046 *                                         |
|FISHER EXACT           |               P=0.500      P=0.268N     P=0.154N   |               P=0.553N     P=0.449      P=0.092    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  29
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    1/50 (2%)    5/50 (10%)   3/50 (6%)  |  1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         4.8%        27.1%        21.1%      |   2.3%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/13 (0%)    0/9 (0%)     0/5 (0%)     0/4 (0%)   |  0/29 (0%)    0/28 (0%)    0/26 (0%)    0/21 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          670          497          609       |   600          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.039 *    P=0.500      P=0.014 *    P=0.061    |  P=0.412N     P=0.495N     P=0.519N     P=0.505N   |
|INCIDENTAL TUMOR       |  P=0.154      P=0.592      P=0.045 *    P=0.164    |  P=0.320N     P=0.638N     P=0.436N     P=0.419N   |
|LOGISTIC REGRESSION    |  P=0.092      P=0.494      P=0.031 *    P=0.089    |  P=0.406N     P=0.477N     P=0.490N     P=0.493N   |
|COCHRAN-ARMITAGE       |  P=0.113                                           |  P=0.404N                                          |
|FISHER EXACT           |               P=0.500      P=0.028 *    P=0.121    |               P=0.495N     P=0.495N     P=0.495N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 50/50 (100%) 50/50 (100%) 50/50 (100%) 48/50 (96%) | 44/49 (90%)  48/50 (96%)  49/50 (98%)  46/50 (92%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  95.6%       100.0%       100.0%        95.8%      |
|TERMINAL (d)           | 13/13 (100%)  9/9 (100%)   5/5 (100%)   4/4 (100%) | 27/29 (93%)  28/28 (100%) 26/26 (100%) 19/21 (90%) |
|FIRST INCIDENCE (DAYS) |   469          357          460          307       |   366          302          450          433       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.013 *    P=0.308      P=0.013 *    P=0.021 *  |  P=0.046 *    P=0.326      P=0.092      P=0.067    |
|INCIDENTAL TUMOR       |  P=0.147N       (e)          (e)        P=0.550N   |  P=0.501      P=0.212      P=0.068      P=0.454    |
|LOGISTIC REGRESSION    |  P=0.170N       (e)          (e)        P=0.576N   |  P=0.584      P=0.184      P=0.081      P=0.454    |
|COCHRAN-ARMITAGE       |  P=0.043N*                                         |  P=0.588N                                          |
|FISHER EXACT           |               P=1.000N     P=1.000N     P=0.247N   |               P=0.210      P=0.098      P=0.487    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  30
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   CONTROL      12.8 PPM     32 PPM       80 PPM    |   CONTROL      12.8 PPM     32 PPM       80 PPM    |
|                       |                                                    |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 40/50 (80%)  37/50 (74%)  37/50 (74%)  36/50 (72%) | 26/49 (53%)  26/50 (52%)  31/50 (62%)  37/50 (74%) |
|ADJUSTED (b)           |  95.0%        94.4%        96.5%        96.9%      |  60.2%        61.5%        68.2%        89.7%      |
|TERMINAL (d)           | 11/13 (85%)   7/9 (78%)    4/5 (80%)    3/4 (75%)  | 13/29 (45%)  12/28 (43%)  12/26 (46%)  17/21 (81%) |
|FIRST INCIDENCE (DAYS) |   489          525          497          305       |   366          485          470          525       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.026 *    P=0.465      P=0.047 *    P=0.048 *  |  P=0.002 **   P=0.539N     P=0.168      P=0.008 ** |
|INCIDENTAL TUMOR       |  P=0.315N     P=0.338N     P=0.460N     P=0.213N   |  P=0.028 *    P=0.505      P=0.362      P=0.034 *  |
|LOGISTIC REGRESSION    |  P=0.496N     P=0.370N     P=0.547N     P=0.434N   |  P=0.020 *    P=0.538N     P=0.322      P=0.027 *  |
|COCHRAN-ARMITAGE       |  P=0.262N                                          |  P=0.009 **                                        |
|FISHER EXACT           |               P=0.318N     P=0.318N     P=0.241N   |               P=0.538N     P=0.243      P=0.025 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 50/50 (100%) 50/50 (100%) 50/50 (100%) 50/50 (100%)| 47/49 (96%)  50/50 (100%) 50/50 (100%) 49/50 (98%) |
|ADJUSTED (b)           | 100.0%       100.0%       100.0%       100.0%      |  95.9%       100.0%       100.0%        98.0%      |
|TERMINAL (d)           | 13/13 (100%)  9/9 (100%)   5/5 (100%)   4/4 (100%) | 27/29 (93%)  28/28 (100%) 26/26 (100%) 20/21 (95%) |
|FIRST INCIDENCE (DAYS) |   469          357          460          305       |   366          302          450          433       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.007 **   P=0.308      P=0.013 *    P=0.013 *  |  P=0.044 *    P=0.396      P=0.163      P=0.071    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.666      P=0.246      P=0.262      P=0.613    |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.666      P=0.246      P=0.262      P=0.613    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.575                                           |
|FISHER EXACT           |               P=1.000N     P=1.000N     P=1.000N   |               P=0.242      P=0.242      P=0.492    |
|=================================================================================================================================|
         DATE: 09/13/96                     EXPERIMENT: 05136 TEST: 07                                                 PAGE  31
                             STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- 9-8CHLOROPRENE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
                                                                           
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.