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TDMS Study 05143-01 Pathology Tables


NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Mason                                                     DATE: 09/17/94   
EXP: 05143                   CORN OIL / CORN OIL               TIME: 18:54:35   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 00577    
CONT: N01-ES-55123                                             CAS: 8001-30-7   
PATHOLOGIST: K. MURTHY                       S. EUSTIS                          
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REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


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TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Mason                                                     DATE: 09/17/94  
EXP: 05143                   CORN OIL / CORN OIL               TIME: 18:54:35  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 00577   
CONT: N01-ES-55123                                             CAS: 8001-30-7  
PATHOLOGIST: K. MURTHY                       S. EUSTIS                         

                                CORN OIL / CORN OIL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 ML/KG                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      216   523   569   610   618   620   635   638   651   678                 |
 |      681   683   685   687   688   688   691   697   697   704                 |
 |      704   704   710   715                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10      ML/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      272   360   483   591   598   600   628   658   661   661                 |
 |      670   671   685   701   707   719   723   726                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 2.5      ML/KG                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      409   420   520   562   575   586   599   619   653   656                 |
 |      669   670   678   695   705   707   720                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                CORN OIL / CORN OIL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 5.0     ML/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      386   432   555   560   562   569   576   632   706   707                 |
 |      721   726                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10.0    ML/KG                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 10     CENSORED DEATHS 0    TERMINAL 40        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      575   576   622   623   664   672   680   692   705   722                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                CORN OIL / CORN OIL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 ML/KG    |   100.0 100.0  98.0  98.0  98.0  98.0  96.0  94.0  82.0  52.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0 100.0  96.0  96.0  94.0  94.0  88.0  80.0  64.0      |
 |ML/KG      |                                                                    |
 |           |                                                                    |
 |2.5        |   100.0 100.0 100.0 100.0  96.0  96.0  94.0  86.0  80.0  66.0      |
 |ML/KG      |                                                                    |
 |           |                                                                    |
 |5.0        |   100.0 100.0 100.0 100.0  98.0  96.0  96.0  86.0  84.0  76.0      |
 |ML/KG      |                                                                    |
 |           |                                                                    |
 |10.0       |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  96.0  90.0  80.0      |
 |ML/KG      |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                CORN OIL / CORN OIL


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                           DOSE                                              |
 |                                                                                                                             |
 |                                0 ML/KG            10                 2.5                5.0                10.0             |
 |                                                   ML/KG              ML/KG              ML/KG              ML/KG            |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.0%              64.0%              66.0%              76.0%              80.0%            |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.017N            -----             P=0.305N           P=0.029N           P=0.007N         |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       645.5              617.4              614.3              594.3              653.1            |
 |NATURAL DEATHS (C)      |       (21.1)             (29.7)             (22.9)             (31.9)             (16.4)           |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       688.9              688.8              690.0              696.7              713.8            |
 |(STANDARD ERROR)        |       (11.6)             (13.0)             (10.9)             (11.1)             ( 5.4)           |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                        CORN OIL / CORN OIL
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 ML/KG          = 1
                                                        10      ML/KG    = 2
                                                        2.5      ML/KG   = 3
                                                        5.0     ML/KG    = 4
                                                        10.0    ML/KG    = 5

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                                 1        2                  4  3                         5
      |
      |                                   1        2             2    4  33 4              1
      |                                                          2        3 4       2      1    4 15      5
   95 +
      |                                                                             2      3     31   2  1
      |                                                                                         43 3  22 11      5
      |
   90 +                                                                                          4433            55
      |
      |                                                                                           443  2  121     5 5
      |                                                                                            4   3  3211 2    55
P  85 +
E     |                                                                                                   3 4112 2   5 4
R     |                                                                                                       1    1   5  5
C     |
E  80 +                                                                                                        3 2211  4 45 5
N     |
T     |                                                                                                                  44
      |                                                                                                           232     4 4
S  75 +
U     |                                                                                                            31132
R     |                                                                                                               33
V     |
I  70 +                                                                                                                2 2
V     |
A     |                                                                                                                3 22
L     |                                                                                                              11  3  3
   65 +
      |                                                                                                                   2 2
      |                                                                                                               11
      |
   60 +
      |
      |
      |                                                                                                                11
   55 +
      |                                                                                                                 11
      |                                                                                                                  1  1
      |
   50 +
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 15 obs hidden.