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TDMS Study 05158-04 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                    MOLYBDENUM TRIOXIDE                                 DATE: 04/04/96       
EXPERIMENT: 05158 TEST: 04                                                                                     TIME: 02:49:15       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-95240                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61369C       
PATHOLOGIST: R. MILLER                                                                                         CAS: 1313-27-5       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                    MOLYBDENUM TRIOXIDE                                 DATE: 04/04/96      
EXPERIMENT: 05158 TEST: 04                                                                                     TIME: 02:49:15      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-95240                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 61369C      
PATHOLOGIST: R. MILLER                                                                                         CAS: 1313-27-5      
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      350   433   435   473   544   580   592   629   636   651                 |
 |      651   656   698   712                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      448   549   580   587   653   653   655   664   689   692                 |
 |      692   699   705   708   709   720   723                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 30 MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      365   440   442   451   451   513   513   513   516   538                 |
 |      551   553   631   638   667   669   679   685   692   705                 |
 |      709   713   715   729   730                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 100     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      328   408   576   580   592   629   636   670   677   686                 |
 |      690   715   720                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  98.0  98.0  92.0  90.0  86.0  76.0  72.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10 MG/M3   |   100.0 100.0 100.0 100.0 100.0  98.0  98.0  92.0  84.0  66.0      |
 |           |                                                                    |
 |           |                                                                    |
 |30 MG/M3   |   100.0 100.0 100.0  98.0  98.0  90.0  80.0  76.0  72.0  50.0      |
 |           |                                                                    |
 |           |                                                                    |
 |100        |   100.0 100.0 100.0  98.0  96.0  96.0  96.0  90.0  86.0  74.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      10 MG/M3     30 MG/M3     100      |
 |                                                                       MG/M3    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       72.0%        66.0%        50.0%        74.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.536N     P=0.843      P=0.052      P=0.908N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       574.3        654.5        592.3        608.2    |
 |NATURAL DEATHS (C)      |       (29.7)       (17.9)       (22.5)       (32.7)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       688.6        706.3        662.7        700.6    |
 |(STANDARD ERROR)        |       (13.0)       ( 8.0)       (15.0)       (11.4)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      469   511   548   552   552   562   581   587   590   594                 |
 |      626   634   636   642   670   674   692   692   692   705                 |
 |      709   720   720   729   730                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 10 MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 1    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      220   456   531   592   594   600   610   619   629   636                 |
 |      639   670   681   692   709   709   723   730                             |
 |  CENSORED DEATHS                                                               |
 |      692                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 30 MG/M3                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 1    TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      288   562   603   638   653   670   678   689   692   705                 |
 |      705   709   712   712   720   723                                         |
 |  CENSORED DEATHS                                                               |
 |      566                                                                       |
 |                                                                                |
 ==================================================================================
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 100     MG/M3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      165   302   350   498   531   534   620   632   650   664                 |
 |      667   671   698   699   715                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                MOLYBDENUM TRIOXIDE

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  80.0  72.0  50.0      |
 |           |                                                                    |
 |           |                                                                    |
 |10 MG/M3   |   100.0 100.0  98.0  98.0  98.0  96.0  94.0  88.0  78.0  63.8      |
 |           |                                                                    |
 |           |                                                                    |
 |30 MG/M3   |   100.0 100.0 100.0  98.0  98.0  98.0  98.0  94.0  89.9  67.4      |
 |           |                                                                    |
 |           |                                                                    |
 |100        |   100.0  98.0  98.0  94.0  94.0  94.0  88.0  88.0  80.0  70.0      |
 |MG/M3      |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      10 MG/M3     30 MG/M3     100      |
 |                                                                       MG/M3    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       50.0%        63.8%        67.4%        70.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.174N     P=0.230N     P=0.074N     P=0.096N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       632.7        613.3        653.7        559.7    |
 |NATURAL DEATHS (C)      |       (14.9)       (28.4)       (26.8)       (42.9)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       682.8        689.1        704.3        681.0    |
 |(STANDARD ERROR)        |       (10.3)       (12.9)       (10.3)       (16.9)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                        MOLYBDENUM TRIOXIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        10 MG/M3         = 2
                                                        30 MG/M3         = 3
                                                        100     MG/M3    = 4

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                                                   4  1  3           2
      |
      |                                                     4  1  3      4  132                2
      |                                                                  4  113                2   2
   95 +
      |                                                                      13 3  1               22
      |                                                                            1          1    42 4        2
      |
   90 +                                                                         3        3    1    1  4    4
      |
      |                                                                                            1  1    44
      |                                                                                               1    14  2 24
P  85 +
E     |                                                                                                    11    244 2
R     |                                                                                  3   3              1 1    44
C     |
E  80 +                                                                                      3 3                    44
N     |
T     |                                                                                                       11     22  4
      |                                                                                        3            3  1      12
S  75 +
U     |                                                                                                     33        1214  4
R     |                                                                                                      3    3     1   1
V     |
I  70 +                                                                                                                 22
V     |
A     |                                                                                                           33     22
L     |                                                                                                            33     2 2
   65 +
      |                                                                                                             33
      |                                                                                                              3 3
      |
   60 +                                                                                                                33
      |
      |
      |                                                                                                                 33
   55 +
      |                                                                                                                  3  3
      |
      |
   50 +                                                                                                                     3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 8 obs hidden.
                                                        MOLYBDENUM TRIOXIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        10 MG/M3         = 2
                                                        30 MG/M3         = 3
                                                        100     MG/M3    = 4

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                         4        2          3                           1
      |
      |                           4        2          3 4                        21     1        3
      |                                                 4      4                 2      1   2  1 3      3
   95 +
      |                                                        4                       4    2         2 3    3
      |                                                                                4    4                3 3
      |
   90 +                                                                                     44 1 1    22       3  3
      |
      |                                                                                      4   1 1   2 24       33
      |                                                                                            11    22 4      3 3
P  85 +
E     |                                                                                             1 1   224 4
R     |                                                                                                    22 4  4
C     |                                                                                                              3 3
E  80 +                                                                                               1    122   44
N     |
T     |                                                                                                    112    2    33
      |                                                                                                           2 2 4
S  75 +
U     |                                                                                                     11      22
R     |                                                                                                      1    1  24 24
V     |                                                                                                                 33
I  70 +                                                                                                           11     33 4
V     |
A     |                                                                                                            1 1  2 2 3
L     |                                                                                                                   2 2
   65 +
      |                                                                                                                     2
      |                                                                                                              1 1
      |
   60 +                                                                                                                11
      |
      |                                                                                                                 11
      |
   55 +
      |                                                                                                                  1  1
      |
      |
   50 +                                                                                                                     1
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 7 obs hidden.