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TDMS Study 05161-05 Pathology Tables

                                                                                                                                   
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: Southern Research Inst                               RIDDELLIINE                                               DATE: 12/15/00  
EXPERIMENT: 05161 TEST: 05                                                                                        TIME: 12:04:21    
                                                CAGES FROM 0000 TO LAST CAGE                                      PAGE:    1        
TEST TYPE: CHRONIC                                  ROUTE: GAVAGE                                                 NTP:  C61358C     
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
                                                                                                                                   
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
NTP                                          MEAN BODY WEIGHTS AND SURVIVAL TABLE                                 REPORT: EISRPT41  
LAB: SOUTHERN RESEARCH INSTITUTE                      RIDDELLIINE                                                 DATE: 12/15/00    
EXPERIMENT: 05161 TEST: 05                                                                                        TIME: 12:09:44    
SPECIES: RATS, FISCHER 344                                                                                                          
TEST TYPE: TWO YEAR                                 ROUTE: ORAL GAVAGE                                            NTP:  61358C      
CONT: NO1-ES-55393                                                                                                CAS: 23246-96-0   
                                                                                                                                   
                                                                                                                                    
    MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE                                                                              
        TWO YEAR ORAL GAVAGE STUDY OF RIDDELLIINE                                                                                   
========================================================                                                                            
WEEK     0       MG/KG/DY       1.0     MG/KG/DY                                                                                    
         ----------------       ----------------                                                                                    
          AV.WT.     NO.       AV.WT.  PERCENT  NO.                                                                                 
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)                                                                                
=======================================================                                                                             
  B       119.6       50       119.7    100.1    50                                                                                 
  1       119.6       50       119.7    100.1    50                                                                                 
  5       244.2       50       239.6     98.1    50                                                                                 
  9       316.4       50       306.5     96.9    50                                                                                 
 13       361.3       50       349.2     96.7    50                                                                                 
 17       392.7       50       374.5     95.4    50                                                                                 
 21       418.1       50       396.7     94.9    50                                                                                 
 25       435.1       50       404.9     93.1    50                                                                                 
 29       449.0       50       418.8     93.3    50                                                                                 
 33       465.4       50       431.2     92.7    49                                                                                 
 37       474.9       50       440.3     92.7    49                                                                                 
 41       486.9       50       449.2     92.3    48                                                                                 
 45       491.7       50       452.1     91.9    46                                                                                 
 49       501.3       50       454.1     90.6    42                                                                                 
 53       506.7       50       456.8     90.2    40                                                                                 
 57       509.0       50       452.5     88.9    36                                                                                 
 61       510.1       50       438.0     85.9    16                                                                                 
 65       513.4       50       424.4     82.7     9                                                                                 
 69       519.7       49       411.7     79.2     5                                                                                 
TERM. SAC.            49                          3                                                                                 
========================================================                                                                            
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
                                   MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                             
                                       TWO YEAR ORAL GAVAGE STUDY OF RIDDELLIINE                                                    
==========================================================================================================================          
WEEK     0       MG/KG/DY       0.01    MG/KG/DY         0.033   MG/KG/DY         0.1     MG/KG/DY         0.33    MG/KG/DY         
         ----------------       ----------------         ----------------         ----------------         ----------------         
          AV.WT.     NO.       AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.     AV.WT.  PERCENT  NO.      
         (GRAMS)     (A)       (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)    (GRAMS)  OF CNTL  (A)     
==================================================================================================================================  
  B        94.7       50        95.1    100.4    50      95.7    101.1    50      95.1    100.4    50      94.7    100.0    50      
  1        94.7       50        95.1    100.4    50      95.7    101.1    50      95.1    100.4    50      94.7    100.0    50      
  5       155.0       50       154.1     99.4    50     155.1    100.1    50     152.5     98.4    50     153.1     98.8    50      
  9       181.8       50       182.5    100.4    50     182.0    100.1    50     178.9     98.4    50     181.2     99.7    50      
 13       196.4       50       194.5     99.0    50     196.9    100.3    50     194.4     99.0    50     194.6     99.1    50      
 17       202.5       50       204.3    100.9    50     204.9    101.2    50     202.0     99.8    50     202.7    100.1    50      
 21       214.4       50       216.0    100.7    50     215.3    100.4    50     212.4     99.1    50     216.5    101.0    50      
 25       218.2       50       218.9    100.3    50     219.3    100.5    50     217.0     99.5    50     218.9    100.3    50      
 29       225.9       50       228.0    100.9    50     227.8    100.8    50     223.3     98.8    50     224.2     99.2    50      
 33       232.9       50       235.1    100.9    50     235.8    101.2    50     232.5     99.8    50     232.2     99.7    50      
 37       238.2       50       240.2    100.8    50     239.7    100.6    50     236.4     99.2    49     235.9     99.0    50      
 41       246.8       50       249.1    100.9    50     247.9    100.4    50     245.6     99.5    49     244.5     99.1    50      
 45       250.7       50       251.7    100.4    50     253.4    101.1    50     250.8    100.0    47     247.9     98.9    50      
 49       259.1       50       259.9    100.3    49     260.1    100.4    50     255.0     98.4    47     256.4     99.0    50      
 53       268.3       50       270.7    100.9    49     269.0    100.3    50     266.1     99.2    47     264.3     98.5    50      
 57       277.1       49       277.4    100.1    49     276.6     99.8    50     272.6     98.4    47     270.5     97.6    50      
 61       281.1       49       287.1    102.1    48     283.6    100.9    50     279.4     99.4    47     276.7     98.4    50      
 65       291.9       48       296.1    101.4    48     293.3    100.5    48     288.3     98.8    46     282.3     96.7    50      
 69       303.9       47       305.6    100.6    48     300.8     99.0    48     295.7     97.3    46     293.5     96.6    48      
 73       306.5       45       308.3    100.6    48     302.6     98.7    48     300.2     97.9    46     297.0     96.9    48      
 77       308.5       45       310.7    100.7    45     306.0     99.2    46     301.5     97.7    46     301.3     97.7    47      
 81       310.4       44       310.5    100.0    44     308.5     99.4    45     304.9     98.2    44     299.4     96.5    47      
 85       315.1       44       315.9    100.3    43     311.4     98.8    43     310.0     98.4    44     303.8     96.4    42      
 89       316.2       42       318.3    100.7    39     318.5    100.7    39     311.5     98.5    43     304.4     96.3    41      
 93       319.4       39       318.1     99.6    32     321.9    100.8    37     309.6     96.9    39     307.8     96.4    39      
 97       319.9       37       320.3    100.1    29     316.5     98.9    32     311.8     97.5    33     309.3     96.7    33      
101       322.1       35       317.7     98.6    26     319.8     99.3    30     315.8     98.0    28     312.8     97.1    29      
TERM. SAC.            33                         22                       28                       22                       29      
==========================================================================================================================          
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.                                                                              
                                                                                                                                   
                                                                                                                                    
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE                                                                                
TWO YEAR ORAL GAVAGE STUDY OF RIDDELLIINE                                                                                           
===============================                                                                                                     
     1.0     MG/KG/DY                                                                                                               
WEEK ----------------                                                                                                               
      AV.WT.  PERCENT  NO.                                                                                                          
     (GRAMS)  OF CNTL  (A)                                                                                                          
==============================                                                                                                      
  B    94.5     99.8    50                                                                                                          
  1    94.5     99.8    50                                                                                                          
  5   153.4     99.0    50                                                                                                          
  9   178.2     98.0    50                                                                                                          
 13   189.4     96.4    50                                                                                                          
 17   196.8     97.2    50                                                                                                          
 21   206.1     96.1    50                                                                                                          
 25   207.9     95.3    50                                                                                                          
 29   212.4     94.0    50                                                                                                          
 33   219.6     94.3    50                                                                                                          
 37   223.6     93.9    50                                                                                                          
 41   232.3     94.1    50                                                                                                          
 45   233.4     93.1    50                                                                                                          
 49   239.2     92.3    50                                                                                                          
 53   245.8     91.6    48                                                                                                          
 57   251.4     90.7    47                                                                                                          
 61   254.4     90.5    44                                                                                                          
 65   260.3     89.2    39                                                                                                          
 69   272.3     89.6    29                                                                                                          
 73   269.9     88.1    25                                                                                                          
 77   267.8     86.8    18                                                                                                          
 81   264.3     85.1    10                                                                                                          
 85   284.6     90.3     4                                                                                                          
 89   289.2     91.5     2                                                                                                          
 93   262.4     82.2     2                                                                                                          
 97                                                                                                                                 
101                                                                                                                                 
TERM. SAC.               0                                                                                                          
===============================                                                                                                     
    (A) NUMBER OF ANIMALS WEIGHED.  AT TERMINAL SACRIFICE, NUMBER                                                                   
        OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.                                                                        
    (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.                                                                              
    (I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.                                                                                    
    (*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK                                                                                 
         IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.