TDMS Study 05161-05 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst RIDDELLIINE DATE: 12/15/00
EXPERIMENT: 05161 TEST: 05 TIME: 12:21:09
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-55393 ROUTE: GAVAGE NTP C#: 61358C
PATHOLOGIST: HEATH, JAMES E. CAS: 23246-96-0
------------------------------------------------------------------------------------------------------------------------------------
RATS/FINAL#1 MALES
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 MG/KG/DY
INCLUDE 002 1.0 MG/KG/DY
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst RIDDELLIINE DATE: 12/15/00
EXPERIMENT: 05161 TEST: 05 TIME: 12:21:09
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-55393 ROUTE: GAVAGE NTP C#: 61358C
PATHOLOGIST: HEATH, JAMES E. CAS: 23246-96-0
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 497 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 1 CENSORED DEATHS 0 TERMINAL 49 |
| |
| UNCENSORED DEATHS |
| 468 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 1.0 MG/KG/DY |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 45 CENSORED DEATHS 2 TERMINAL 3 |
| |
| UNCENSORED DEATHS |
| 204 297 307 314 318 327 342 364 373 373 |
| 375 388 397 397 398 400 400 402 402 403 |
| 407 407 408 410 411 412 414 414 415 415 |
| 418 419 422 424 433 437 440 440 446 449 |
| 457 462 463 477 483 |
| CENSORED DEATHS |
| 266 321 |
| |
==================================================================================
RIDDELLIINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 497 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 50 100 150 200 250 300 350 400 450 497 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 | 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 98.0 |
|MG/KG/DY | |
| | |
|1.0 | 100.0 100.0 100.0 100.0 98.0 96.0 85.7 71.0 18.8 6.3 |
|MG/KG/DY | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 1.0 |
| MG/KG/DY MG/KG/DY |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 98.0% 6.3% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P<0.001 P<0.001 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 468.0 399.2 |
|NATURAL DEATHS (C) | ( . ) ( 7.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 496.4 400.8 |
|(STANDARD ERROR) | ( 0.6) ( 8.4) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
RIDDELLIINE
KAPLAN-MEIER SURVIVAL CURVES
0 MG/KG/DY = 1
1.0 MG/KG/DY = 2
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1
| 2 2 1 1
| 22 2
| 22
90 + 22
| 2 2
| 2 2
| 2 2
80 +
| 2 2
| 22
|
P 70 + 22
E |
R |
C |
E 60 +
N | 2 2
T |
|
S 50 +
U |
R | 22
V |
I 40 +
V |
A |
L | 22
30 + 2 2
| 22
|
|
20 + 22 2
| 22
|
| 22
10 + 2 2
| 2 2
|
|
0 +
|
---+------------+------------+------------+------------+------------+------------+------------+------------+--
0 10 20 30 40 50 60 70 80
WEEK
NOTE: 3 obs hidden.