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TDMS Study 05161-05 Pathology Tables

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00

Route: GAVAGE                                                                                                     Time: 12:06:03



                                                          RATS/FINAL#1









       Facility:  Southern Research Institute



       Chemical CAS #:  23246-96-0



       Lock Date:  11/17/99



       Cage Range:  All



       Reasons For Removal:    All



       Removal Date Range:     All



       Treatment Groups:       Include All





































































Note:  Animals arranged according to CID number



                                                              Page   1





NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|             

                             DAY ON TEST   | 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 7| 7| 2| 2| 2| 2| 3| 3| 3| 3| 3|             

                                           | 0| 8| 0| 4| 0| 1| 1| 1| 1| 1| 6| 6| 1| 8| 2| 8| 9| 9| 9| 9| 0| 7| 0| 0| 0|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             

    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 ALIMENTARY SYSTEM                         |                                                                          |             

                                           |__________________________________________________________________________|             

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             

      Polyp Adenomatous                    |                                                       X                  |             

                                           |__________________________________________________________________________|             

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

                                           |__________________________________________________________________________|             

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Hepatocellular Adenoma               |                                                                          |             

      Leukemia Mononuclear                 | X                                         X     X                    X  X|             

                                           |__________________________________________________________________________|             

   Mesentery                               |                   +                             +           +            |             

                                           |__________________________________________________________________________|             

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Acinus, Adenoma                      |             X                                                            |             

                                           |__________________________________________________________________________|             

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 CARDIOVASCULAR SYSTEM                     |                                                                          |             

                                           |__________________________________________________________________________|             

   Blood Vessel                            |    +                                                                     |             

                                           |__________________________________________________________________________|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   2                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|             

                             DAY ON TEST   | 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 7| 7| 2| 2| 2| 2| 3| 3| 3| 3| 3|             

                                           | 0| 8| 0| 4| 0| 1| 1| 1| 1| 1| 6| 6| 1| 8| 2| 8| 9| 9| 9| 9| 0| 7| 0| 0| 0|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             

    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             

                                           |                                                                          |             

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 ENDOCRINE SYSTEM                          |                                                                          |             

                                           |__________________________________________________________________________|             

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                                                                          |             

      Leukemia Mononuclear                 |                                           X     X                    X   |             

                                           |__________________________________________________________________________|             

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                           X     X                        |             

      Pheochromocytoma Malignant           |                                                                          |             

      Pheochromocytoma Benign              |                                                                          |             

                                           |__________________________________________________________________________|             

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                      X                                                   |             

                                           |__________________________________________________________________________|             

   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

      Pars Distalis, Adenoma               | X     X     X  X     X              X     X  X  X  X     X           X   |             

      Pars Distalis, Adenoma, Multiple     |                                                                          |             

                                           |__________________________________________________________________________|             

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Bilateral, C-Cell, Adenoma           |                                                             X            |             

      C-Cell, Adenoma                      |                            X                                             |             

      C-Cell, Carcinoma                    |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 GENERAL BODY SYSTEM                       |                                                                          |             

    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 GENITAL SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |       X                                                     X           X|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   3                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|             

                             DAY ON TEST   | 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 7| 7| 2| 2| 2| 2| 3| 3| 3| 3| 3|             

                                           | 0| 8| 0| 4| 0| 1| 1| 1| 1| 1| 6| 6| 1| 8| 2| 8| 9| 9| 9| 9| 0| 7| 0| 0| 0|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             

    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 GENITAL SYSTEM - cont                     |                                                                          |             

                                           |                                                                          |             

      Carcinoma                            |                                                       X        X         |             

      Bilateral, Adenoma                   |                                                                          |             

                                           |__________________________________________________________________________|             

   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

      Luteoma                              |                      X                                                   |             

                                           |__________________________________________________________________________|             

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Carcinoma                            |                                                                         X|             

      Leiomyoma                            |                                                                   X      |             

      Polyp Stromal                        |          X                    X        X        X     X                  |             

      Polyp Stromal, Multiple              |                                                                          |             

                                           |__________________________________________________________________________|             

   Vagina                                  |                                           +                              |             

 _____________________________________________________________________________________________________________________|             

 HEMATOPOIETIC SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                           X                          X   |             

                                           |__________________________________________________________________________|             

   Lymph Node                              |          +  +     +     +  +     +        +  +  +        +  +  +         |             

      Mediastinal, Leukemia Mononuclear    |                                           X     X                        |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                 X                    X   |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                 X                        |             

                                           |__________________________________________________________________________|             

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X                 X                       X     X                    X  X|             

                                           |__________________________________________________________________________|             

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             

      Thymoma Malignant                    |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 INTEGUMENTARY SYSTEM                      |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   4                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|             

                             DAY ON TEST   | 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 7| 7| 2| 2| 2| 2| 3| 3| 3| 3| 3|             

                                           | 0| 8| 0| 4| 0| 1| 1| 1| 1| 1| 6| 6| 1| 8| 2| 8| 9| 9| 9| 9| 0| 7| 0| 0| 0|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             

    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 INTEGUMENTARY SYSTEM - cont               |                                                                          |             

                                           |                                                                          |             

                                           |__________________________________________________________________________|             

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |             X                                                            |             

      Carcinoma                            |       X                                                                  |             

      Fibroadenoma                         | X              X     X  X  X        X     X           X                  |             

      Fibroadenoma, Multiple               |             X     X                                X        X        X   |             

                                           |__________________________________________________________________________|             

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Basal Cell Carcinoma                 |                                                                          |             

      Myxosarcoma                          |                                        X                                 |             

      Schwannoma Malignant                 |                                                                          |             

      Subcutaneous Tissue, Fibroma         |                                                                          |             

      Subcutaneous Tissue, Fibrosarcoma    |                                                                          |             

      Subcutaneous Tissue, Lipoma          |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 MUSCULOSKELETAL SYSTEM                    |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 NERVOUS SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Peripheral Nerve                        |                                                                          |             

                                           |__________________________________________________________________________|             

   Spinal Cord                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 RESPIRATORY SYSTEM                        |                                                                          |             

                                           |__________________________________________________________________________|             

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Alveolar/Bronchiolar Adenoma         |                                                                          |             

      Leukemia Mononuclear                 |                                           X                          X   |             

                                           |__________________________________________________________________________|             

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   5                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 4| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 7| 4| 6| 6| 7| 7| 7| 7| 7| 4| 7| 7| 7|             

                             DAY ON TEST   | 3| 6| 3| 5| 3| 3| 3| 3| 3| 3| 3| 2| 3| 9| 7| 7| 2| 2| 2| 2| 3| 3| 3| 3| 3|             

                                           | 0| 8| 0| 4| 0| 1| 1| 1| 1| 1| 6| 6| 1| 8| 2| 8| 9| 9| 9| 9| 0| 7| 0| 0| 0|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             

    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 SPECIAL SENSES SYSTEM                     |                                                                          |             

                                           |__________________________________________________________________________|             

   Lacrimal Gland                          |                +                                                         |             

 _____________________________________________________________________________________________________________________|             

 URINARY SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

                                           |__________________________________________________________________________|             

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Papilloma                            |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

 SYSTEMIC LESIONS                          |                                                                          |             

                                            __________________________________________________________________________|             

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X                 X                       X     X                    X  X|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page   6                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 6| 3| 7| 7| 7| 7|            |

                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 1| 4| 8| 1| 1| 9| 3| 3| 3| 3|            |

                                           | 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 1| 1| 0| 1| 1| 1| 5| 3| 0| 1| 3| 0| 0| 0| 0|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |

    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Polyp Adenomatous                    |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                X                                                         |          1 |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Hepatocellular Adenoma               |                   X                                                      |          1 |

      Leukemia Mononuclear                 |    X           X  X                                      X  X     X      |         11 |

                                           |__________________________________________________________________________|____________|

   Mesentery                               |       +     +        +        +        +     +        +                  |  10        |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Acinus, Adenoma                      |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                X                                                         |          1 |

 _____________________________________________________________________________________________________________________|            |

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page   7                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 6| 3| 7| 7| 7| 7|            |

                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 1| 4| 8| 1| 1| 9| 3| 3| 3| 3|            |

                                           | 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 1| 1| 0| 1| 1| 1| 5| 3| 0| 1| 3| 0| 0| 0| 0|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |

    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Blood Vessel                            |                                                                          |   1        |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                   X                                                      |          1 |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                          X               |          1 |

      Leukemia Mononuclear                 |                X                                                         |          4 |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          2 |

      Pheochromocytoma Malignant           |                                                          X               |          1 |

      Pheochromocytoma Benign              |                                  X                                       |          1 |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                                X         |          2 |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                X                                                         |          1 |

      Pars Distalis, Adenoma               | X  X        X  X  X  X              X     X  X  X     X  X     X     X   |         26 |

      Pars Distalis, Adenoma, Multiple     |                                  X                                       |          1 |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |

      Bilateral, C-Cell, Adenoma           |                                                                          |          1 |

      C-Cell, Adenoma                      |                                                                          |          1 |

      C-Cell, Carcinoma                    |          X                                                               |          1 |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                             Page   8                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 6| 3| 7| 7| 7| 7|            |

                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 1| 4| 8| 1| 1| 9| 3| 3| 3| 3|            |

                                           | 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 1| 1| 0| 1| 1| 1| 5| 3| 0| 1| 3| 0| 0| 0| 0|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |

    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |

      Adenoma                              |    X                                      X                              |          5 |

      Carcinoma                            |          X                                                               |          3 |

      Bilateral, Adenoma                   |                                                                X        X|          2 |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                X                                                         |          1 |

      Luteoma                              |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Carcinoma                            |                                                                          |          1 |

      Leiomyoma                            |                                                                          |          1 |

      Polyp Stromal                        |    X        X                 X                                X         |          9 |

      Polyp Stromal, Multiple              | X                                                     X                  |          2 |

                                           |__________________________________________________________________________|____________|

   Vagina                                  | +                                                                        |   2        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X           X  X                                                      |          5 |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              | +     +  +     +  +  +        +                 +  +  +  +  +     +  +   |  26        |

      Mediastinal, Leukemia Mononuclear    |                X  X                                         X            |          5 |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                          X               |          3 |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page   9                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 6| 3| 7| 7| 7| 7|            |

                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 1| 4| 8| 1| 1| 9| 3| 3| 3| 3|            |

                                           | 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 1| 1| 0| 1| 1| 1| 5| 3| 0| 1| 3| 0| 0| 0| 0|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |

    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

      Leukemia Mononuclear                 |    X           X  X                                      X  X     X      |         12 |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |

      Thymoma Malignant                    |                                  X                                       |          1 |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                                          |          1 |

      Carcinoma                            |                                              X                           |          2 |

      Fibroadenoma                         |          X  X              X           X              X  X     X  X      |         16 |

      Fibroadenoma, Multiple               | X  X                 X  X        X                                   X  X|         12 |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Basal Cell Carcinoma                 |             X                                                            |          1 |

      Myxosarcoma                          |                                                                          |          1 |

      Schwannoma Malignant                 |                                                          X               |          1 |

      Subcutaneous Tissue, Fibroma         |                                                    X                     |          1 |

      Subcutaneous Tissue, Fibrosarcoma    |    X                                                                     |          1 |

      Subcutaneous Tissue, Lipoma          |                                                       X                  |          1 |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Peripheral Nerve                        |                +                                            +            |   2        |

                                           |__________________________________________________________________________|____________|

   Spinal Cord                             |                +                                            +            |   2        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  10                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 5| 4| 7| 6| 3| 7| 7| 7| 7|            |

                             DAY ON TEST   | 3| 3| 3| 3| 3| 9| 3| 2| 3| 3| 3| 3| 4| 3| 3| 1| 4| 8| 1| 1| 9| 3| 3| 3| 3|            |

                                           | 0| 0| 0| 0| 0| 3| 0| 0| 0| 0| 1| 1| 0| 1| 1| 1| 5| 3| 0| 1| 3| 0| 0| 0| 0|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|     A      |

    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Alveolar/Bronchiolar Adenoma         |                            X                                            X|          2 |

      Leukemia Mononuclear                 |                   X                                                      |          3 |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lacrimal Gland                          |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                X                                            X            |          2 |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Papilloma                            | X                                                                        |          1 |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X           X  X                                      X  X     X      |         12 |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  11                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7|             

                             DAY ON TEST   | 9| 1| 5| 2| 3| 1| 3| 3| 3| 3| 7| 2| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 0| 7| 3|             

                                           | 3| 9| 0| 0| 1| 8| 1| 1| 1| 1| 3| 9| 9| 9| 5| 1| 1| 1| 3| 1| 1| 1| 0| 2| 1|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             

    0.01                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 ALIMENTARY SYSTEM                         |                                                                          |             

                                           |__________________________________________________________________________|             

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Lipoma                               |                                                             X            |             

                                           |__________________________________________________________________________|             

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Jejunum                | +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Ileum                  | +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |             X                 X           X           X              X   |             

                                           |__________________________________________________________________________|             

   Mesentery                               |       +                 +     +  +     +           +        +        +   |             

                                           |__________________________________________________________________________|             

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                           X                              |             

                                           |__________________________________________________________________________|             

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                           X           X                  |             

 _____________________________________________________________________________________________________________________|             

 CARDIOVASCULAR SYSTEM                     |                                                                          |             

                                           |__________________________________________________________________________|             

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 ENDOCRINE SYSTEM                          |                                                                          |             

                                           |__________________________________________________________________________|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  12                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7|             

                             DAY ON TEST   | 9| 1| 5| 2| 3| 1| 3| 3| 3| 3| 7| 2| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 0| 7| 3|             

                                           | 3| 9| 0| 0| 1| 8| 1| 1| 1| 1| 3| 9| 9| 9| 5| 1| 1| 1| 3| 1| 1| 1| 0| 2| 1|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             

    0.01                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 ENDOCRINE SYSTEM - cont                   |                                                                          |             

                                           |                                                                          |             

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                                                          X               |             

      Carcinoma                            | X                                                                        |             

      Leukemia Mononuclear                 |                               X                                          |             

                                           |__________________________________________________________________________|             

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                           X           X                  |             

      Pheochromocytoma Benign              |             X                             X  X              X            |             

                                           |__________________________________________________________________________|             

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                                                                          |             

                                           |__________________________________________________________________________|             

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                           X                              |             

      Pars Distalis, Adenoma               |          X     X  X     X  X     X     X     X  X  X     X  X  X  X     X|             

      Pars Distalis, Adenoma, Multiple     |                                                                          |             

                                           |__________________________________________________________________________|             

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      C-Cell, Adenoma                      |    X                 X                                                   |             

      Follicular Cell, Carcinoma           |                                              X                           |             

 _____________________________________________________________________________________________________________________|             

 GENERAL BODY SYSTEM                       |                                                                          |             

    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 GENITAL SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |    X                                            X        X               |             

      Carcinoma                            |                                                                          |             

      Bilateral, Adenoma                   |                                                                          |             

                                           |__________________________________________________________________________|             

   Ovary                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Granulosa Cell Tumor Malignant       |                                                             X            |             

                                           |__________________________________________________________________________|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  13                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7|             

                             DAY ON TEST   | 9| 1| 5| 2| 3| 1| 3| 3| 3| 3| 7| 2| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 0| 7| 3|             

                                           | 3| 9| 0| 0| 1| 8| 1| 1| 1| 1| 3| 9| 9| 9| 5| 1| 1| 1| 3| 1| 1| 1| 0| 2| 1|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             

    0.01                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 GENITAL SYSTEM - cont                     |                                                                          |             

                                           |                                                                          |             

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leiomyosarcoma                       |                                                                          |             

      Polyp Stromal                        |       X  X  X  X     X        X           X                 X  X  X     X|             

                                           |__________________________________________________________________________|             

   Vagina                                  |                               M        +  +                          +   |             

      Leiomyoma                            |                                        X                                 |             

 _____________________________________________________________________________________________________________________|             

 HEMATOPOIETIC SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                               X           X           X              X   |             

                                           |__________________________________________________________________________|             

   Lymph Node                              |       +     +           +  +  +  +     +        +  +  +     +  +  +      |             

      Iliac, Leukemia Mononuclear          |                               X                                          |             

      Mediastinal, Leukemia Mononuclear    |                               X                       X                  |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                               X           X           X              X   |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                               X           X           X              X   |             

                                           |__________________________________________________________________________|             

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X           X                 X           X           X              X   |             

                                           |__________________________________________________________________________|             

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                               X                       X                  |             

      Thymoma Benign                       |                X                                                         |             

 _____________________________________________________________________________________________________________________|             

 INTEGUMENTARY SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                                                                X         |             

      Carcinoma                            |          X                                                           X   |             

      Fibroadenoma                         |       X        X  X              X  X        X        X     X           X|             

      Fibroadenoma, Multiple               |    X                                                           X         |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  14                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7|             

                             DAY ON TEST   | 9| 1| 5| 2| 3| 1| 3| 3| 3| 3| 7| 2| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 0| 7| 3|             

                                           | 3| 9| 0| 0| 1| 8| 1| 1| 1| 1| 3| 9| 9| 9| 5| 1| 1| 1| 3| 1| 1| 1| 0| 2| 1|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             

    0.01                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 INTEGUMENTARY SYSTEM - cont               |                                                                          |             

                                           |                                                                          |             

                                           |__________________________________________________________________________|             

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Basal Cell Adenoma                   | X                                                                        |             

      Keratoacanthoma                      |                                                                          |             

      Squamous Cell Papilloma              |                                                                         X|             

 _____________________________________________________________________________________________________________________|             

 MUSCULOSKELETAL SYSTEM                    |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Skeletal Muscle                         |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 NERVOUS SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Peripheral Nerve                        |                                                                          |             

                                           |__________________________________________________________________________|             

   Spinal Cord                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 RESPIRATORY SYSTEM                        |                                                                          |             

                                           |__________________________________________________________________________|             

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Hepatocellular Carcinoma, Metastatic,|                                                                          |             

           Uncertain Primary Site          |                                                                          |             

      Leukemia Mononuclear                 |                               X           X           X              X   |             

                                           |__________________________________________________________________________|             

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 SPECIAL SENSES SYSTEM                     |                                                                          |             

                                           |__________________________________________________________________________|             

   Zymbal's Gland                          |                                                                          |             

      Carcinoma                            |                                                                          |             

 _____________________________________________________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  15                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 6| 7| 6| 5| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7|             

                             DAY ON TEST   | 9| 1| 5| 2| 3| 1| 3| 3| 3| 3| 7| 2| 7| 2| 1| 3| 3| 3| 1| 3| 3| 3| 0| 7| 3|             

                                           | 3| 9| 0| 0| 1| 8| 1| 1| 1| 1| 3| 9| 9| 9| 5| 1| 1| 1| 3| 1| 1| 1| 0| 2| 1|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             

    0.01                                   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 URINARY SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                           X                              |             

 __________________________________________|__________________________________________________________________________|             

 SYSTEMIC LESIONS                          |                                                                          |             

                                            __________________________________________________________________________|             

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X           X                 X           X           X              X   |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  16                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 6| 7| 6| 6| 6| 7| 6| 4| 5| 6| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 3| 5| 7| 6|            |

                             DAY ON TEST   | 4| 9| 3| 7| 4| 1| 3| 3| 0| 4| 4| 3| 3| 3| 3| 2| 3| 1| 3| 3| 3| 2| 1| 3| 0|            |

                                           | 3| 8| 1| 5| 4| 2| 1| 6| 7| 1| 7| 0| 8| 0| 0| 5| 1| 3| 6| 0| 1| 8| 9| 1| 5|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     A      |

    0.01                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Lipoma                               |                                  X                                       |          2 |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  A  +  +|  43        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|  46        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                               X                                         X|          7 |

                                           |__________________________________________________________________________|____________|

   Mesentery                               | +                                                        +               |  10        |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          2 |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  17                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 6| 7| 6| 6| 6| 7| 6| 4| 5| 6| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 3| 5| 7| 6|            |

                             DAY ON TEST   | 4| 9| 3| 7| 4| 1| 3| 3| 0| 4| 4| 3| 3| 3| 3| 2| 3| 1| 3| 3| 3| 2| 1| 3| 0|            |

                                           | 3| 8| 1| 5| 4| 2| 1| 6| 7| 1| 7| 0| 8| 0| 0| 5| 1| 3| 6| 0| 1| 8| 9| 1| 5|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     A      |

    0.01                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |

                                           |                                                                          |            |

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                                          |          1 |

      Carcinoma                            |                                                                          |          1 |

      Leukemia Mononuclear                 |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Leukemia Mononuclear                 |                               X                                          |          3 |

      Pheochromocytoma Benign              |                                  X                                       |          5 |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                   X                                         X            |          2 |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

      Leukemia Mononuclear                 |                                                                          |          1 |

      Pars Distalis, Adenoma               |                                     X     X     X     X  X           X   |         21 |

      Pars Distalis, Adenoma, Multiple     |                                                             X            |          1 |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      C-Cell, Adenoma                      |    X                                               X                     |          4 |

      Follicular Cell, Carcinoma           |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  18                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 6| 7| 6| 6| 6| 7| 6| 4| 5| 6| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 3| 5| 7| 6|            |

                             DAY ON TEST   | 4| 9| 3| 7| 4| 1| 3| 3| 0| 4| 4| 3| 3| 3| 3| 2| 3| 1| 3| 3| 3| 2| 1| 3| 0|            |

                                           | 3| 8| 1| 5| 4| 2| 1| 6| 7| 1| 7| 0| 8| 0| 0| 5| 1| 3| 6| 0| 1| 8| 9| 1| 5|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     A      |

    0.01                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM - cont                     |                                                                          |            |

                                           |                                                                          |            |

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Adenoma                              |                   X                                      X  X            |          6 |

      Carcinoma                            |                         X        X                                       |          2 |

      Bilateral, Adenoma                   |                                              X                           |          1 |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Granulosa Cell Tumor Malignant       |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leiomyosarcoma                       |          X                                                               |          1 |

      Polyp Stromal                        |                                     X                       X  X         |         14 |

                                           |__________________________________________________________________________|____________|

   Vagina                                  |                                                                          |   3        |

      Leiomyoma                            |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                               X                                          |          5 |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              | +  +  +           +  +        +              +     +  +     +        +   |  24        |

      Iliac, Leukemia Mononuclear          |                                                                          |          1 |

      Mediastinal, Leukemia Mononuclear    |                               X                                          |          3 |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  49        |

      Leukemia Mononuclear                 |                               X                                         X|          6 |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                         X|          5 |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                               X                                         X|          8 |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  19                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 6| 7| 6| 6| 6| 7| 6| 4| 5| 6| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 3| 5| 7| 6|            |

                             DAY ON TEST   | 4| 9| 3| 7| 4| 1| 3| 3| 0| 4| 4| 3| 3| 3| 3| 2| 3| 1| 3| 3| 3| 2| 1| 3| 0|            |

                                           | 3| 8| 1| 5| 4| 2| 1| 6| 7| 1| 7| 0| 8| 0| 0| 5| 1| 3| 6| 0| 1| 8| 9| 1| 5|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     A      |

    0.01                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +|  48        |

      Leukemia Mononuclear                 |                                                                          |          2 |

      Thymoma Benign                       |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                                          |          1 |

      Carcinoma                            |                                                          X               |          3 |

      Fibroadenoma                         | X                    X     X  X        X  X                 X        X   |         17 |

      Fibroadenoma, Multiple               |                                  X                       X               |          4 |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Basal Cell Adenoma                   |                                                                          |          1 |

      Keratoacanthoma                      |                               X                                          |          1 |

      Squamous Cell Papilloma              |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Skeletal Muscle                         |    +                                                                     |   1        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Peripheral Nerve                        |    +                                                                     |   1        |

                                           |__________________________________________________________________________|____________|

   Spinal Cord                             |    +                                                                     |   1        |

 _____________________________________________________________________________________________________________________|            |

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  20                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 6| 7| 6| 6| 6| 7| 6| 4| 5| 6| 7| 6| 7| 7| 7| 6| 6| 6| 7| 7| 3| 5| 7| 6|            |

                             DAY ON TEST   | 4| 9| 3| 7| 4| 1| 3| 3| 0| 4| 4| 3| 3| 3| 3| 2| 3| 1| 3| 3| 3| 2| 1| 3| 0|            |

                                           | 3| 8| 1| 5| 4| 2| 1| 6| 7| 1| 7| 0| 8| 0| 0| 5| 1| 3| 6| 0| 1| 8| 9| 1| 5|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|     A      |

    0.01                                   | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Hepatocellular Carcinoma, Metastatic,|                                                                          |            |

           Uncertain Primary Site          |                      X                                                   |          1 |

      Leukemia Mononuclear                 |                               X                                          |          5 |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Zymbal's Gland                          |             +                                                            |   1        |

      Carcinoma                            |             X                                                            |          1 |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          1 |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                               X                                         X|          8 |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  21                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 6| 7| 5| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7|             

                             DAY ON TEST   | 3| 7| 3| 9| 5| 4| 4| 3| 2| 2| 3| 4| 3| 7| 1| 3| 3| 8| 3| 3| 7| 1| 2| 7| 2|             

                                           | 1| 5| 1| 1| 4| 7| 7| 0| 9| 9| 0| 7| 0| 2| 5| 1| 1| 8| 1| 1| 1| 6| 9| 1| 9|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             

    0.033                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 ALIMENTARY SYSTEM                         |                                                                          |             

                                           |__________________________________________________________________________|             

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                         X                                                |             

                                           |__________________________________________________________________________|             

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  A  A  +  +  +|             

      Polyp Adenomatous                    |                         X                                                |             

                                           |__________________________________________________________________________|             

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A  +  +  A  A  +  +  +|             

                                           |__________________________________________________________________________|             

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X  X        X        X                                            X   |             

                                           |__________________________________________________________________________|             

   Mesentery                               | +                          +           +  +              +  +     +      |             

                                           |__________________________________________________________________________|             

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                X                                                         |             

                                           |__________________________________________________________________________|             

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                         X                                                |             

                                           |__________________________________________________________________________|             

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X                                                                     |             

                                           |__________________________________________________________________________|             

   Tongue                                  | +                                         +                              |             

      Squamous Cell Papilloma              | X                                         X                              |             

 _____________________________________________________________________________________________________________________|             

 CARDIOVASCULAR SYSTEM                     |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  22                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 6| 7| 5| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7|             

                             DAY ON TEST   | 3| 7| 3| 9| 5| 4| 4| 3| 2| 2| 3| 4| 3| 7| 1| 3| 3| 8| 3| 3| 7| 1| 2| 7| 2|             

                                           | 1| 5| 1| 1| 4| 7| 7| 0| 9| 9| 0| 7| 0| 2| 5| 1| 1| 8| 1| 1| 1| 6| 9| 1| 9|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             

    0.033                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             

                                           |                                                                          |             

                                           |__________________________________________________________________________|             

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X           X                                                         |             

 _____________________________________________________________________________________________________________________|             

 ENDOCRINE SYSTEM                          |                                                                          |             

                                           |__________________________________________________________________________|             

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |       X        X                                                     X   |             

                                           |__________________________________________________________________________|             

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |       X        X        X                                            X   |             

      Pheochromocytoma Malignant           |                                        X                                 |             

      Pheochromocytoma Benign              |                      X                                                   |             

                                           |__________________________________________________________________________|             

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                      X     X              X                              |             

      Carcinoma                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             

                                           |__________________________________________________________________________|             

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X           X                                                         |             

      Pars Distalis, Adenoma               | X     X  X  X           X     X        X  X  X  X  X     X  X           X|             

                                           |__________________________________________________________________________|             

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      C-Cell, Adenoma                      |    X           X                                                         |             

 _____________________________________________________________________________________________________________________|             

 GENERAL BODY SYSTEM                       |                                                                          |             

    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 GENITAL SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             

      Adenoma                              |    X                                X                                    |             

      Carcinoma                            |                            X                                             |             

                                           |__________________________________________________________________________|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  23                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 6| 7| 5| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7|             

                             DAY ON TEST   | 3| 7| 3| 9| 5| 4| 4| 3| 2| 2| 3| 4| 3| 7| 1| 3| 3| 8| 3| 3| 7| 1| 2| 7| 2|             

                                           | 1| 5| 1| 1| 4| 7| 7| 0| 9| 9| 0| 7| 0| 2| 5| 1| 1| 8| 1| 1| 1| 6| 9| 1| 9|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             

    0.033                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 GENITAL SYSTEM - cont                     |                                                                          |             

                                           |                                                                          |             

   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Granulosa Cell Tumor Malignant       |                                                                          |             

      Leukemia Mononuclear                 |       X                                                                  |             

                                           |__________________________________________________________________________|             

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Deciduoma Benign                     |                                                                          |             

      Leukemia Mononuclear                 |    X                                                                     |             

      Polyp Stromal                        |    X  X                                               X           X      |             

      Sarcoma Stromal                      |                            X                                             |             

                                           |__________________________________________________________________________|             

   Vagina                                  |          +                 +                                             |             

 _____________________________________________________________________________________________________________________|             

 HEMATOPOIETIC SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X  X        X        X                                            X   |             

                                           |__________________________________________________________________________|             

   Lymph Node                              | +  +  +     +  +     +  +  +     +  +     +  +  +  +     +        +  +  +|             

      Leukemia Mononuclear                 |       X                                                                  |             

      Deep Cervical, Leukemia Mononuclear  |       X                                                                  |             

      Iliac, Leukemia Mononuclear          |       X                                                                  |             

      Mediastinal, Leukemia Mononuclear    |    X  X        X        X                                                |             

      Pancreatic, Leukemia Mononuclear     |    X                    X                                                |             

      Renal, Leukemia Mononuclear          |       X                                                                  |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X  X                 X                                            X   |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X  X        X        X                                            X   |             

                                           |__________________________________________________________________________|             

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X  X        X        X                                            X   |             

                                           |__________________________________________________________________________|             

   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X                    X                                                |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  24                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 6| 7| 5| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7|             

                             DAY ON TEST   | 3| 7| 3| 9| 5| 4| 4| 3| 2| 2| 3| 4| 3| 7| 1| 3| 3| 8| 3| 3| 7| 1| 2| 7| 2|             

                                           | 1| 5| 1| 1| 4| 7| 7| 0| 9| 9| 0| 7| 0| 2| 5| 1| 1| 8| 1| 1| 1| 6| 9| 1| 9|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             

    0.033                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 INTEGUMENTARY SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |       X                                                                  |             

      Carcinoma                            |       X                                                                  |             

      Fibroadenoma                         | X  X        X           X  X     X     X     X     X     X  X     X      |             

      Fibroadenoma, Multiple               |       X  X                                      X                       X|             

                                           |__________________________________________________________________________|             

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Basal Cell Adenoma                   |                                                                   X      |             

      Basal Cell Carcinoma                 |                               X                                          |             

      Keratoacanthoma                      |                                                                          |             

      Subcutaneous Tissue, Fibroma         |             X     X                                                      |             

 _____________________________________________________________________________________________________________________|             

 MUSCULOSKELETAL SYSTEM                    |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Skeletal Muscle                         |                                                                          |             

      Rhabdomyosarcoma                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 NERVOUS SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Granular Cell Tumor Malignant        |                                                                          |             

      Leukemia Mononuclear                 |                                                                          |             

                                           |__________________________________________________________________________|             

   Peripheral Nerve                        |                                                                          |             

                                           |__________________________________________________________________________|             

   Spinal Cord                             |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 RESPIRATORY SYSTEM                        |                                                                          |             

                                           |__________________________________________________________________________|             

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                X                                                         |             

                                           |__________________________________________________________________________|             

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  25                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 6| 7| 5| 6| 6| 6| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7|             

                             DAY ON TEST   | 3| 7| 3| 9| 5| 4| 4| 3| 2| 2| 3| 4| 3| 7| 1| 3| 3| 8| 3| 3| 7| 1| 2| 7| 2|             

                                           | 1| 5| 1| 1| 4| 7| 7| 0| 9| 9| 0| 7| 0| 2| 5| 1| 1| 8| 1| 1| 1| 6| 9| 1| 9|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             

    0.033                                  | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 RESPIRATORY SYSTEM - cont                 |                                                                          |             

                                           |                                                                          |             

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 SPECIAL SENSES SYSTEM                     |                                                                          |             

    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 URINARY SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |       X        X        X                                            X   |             

                                           |__________________________________________________________________________|             

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X                                                                     |             

 __________________________________________|__________________________________________________________________________|             

 SYSTEMIC LESIONS                          |                                                                          |             

                                            __________________________________________________________________________|             

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X  X        X        X                                            X   |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  26                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 7| 7| 7| 5| 5| 5| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7|            |

                             DAY ON TEST   | 3| 3| 3| 6| 1| 9| 3| 1| 3| 1| 2| 3| 4| 2| 2| 3| 9| 3| 2| 3| 2| 2| 2| 5| 2|            |

                                           | 1| 1| 1| 2| 8| 1| 0| 7| 0| 5| 9| 2| 4| 9| 9| 0| 4| 7| 9| 0| 9| 9| 9| 8| 9|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |

    0.033                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +|  48        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

      Polyp Adenomatous                    |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +|  44        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X  X  X              X  X     X                    X     X            |         13 |

                                           |__________________________________________________________________________|____________|

   Mesentery                               | +     +     +     +        +           +     +  +           +  +     +   |  18        |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                            X                                             |          2 |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |          X                 X                                             |          3 |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  27                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 7| 7| 7| 5| 5| 5| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7|            |

                             DAY ON TEST   | 3| 3| 3| 6| 1| 9| 3| 1| 3| 1| 2| 3| 4| 2| 2| 3| 9| 3| 2| 3| 2| 2| 2| 5| 2|            |

                                           | 1| 1| 1| 2| 8| 1| 0| 7| 0| 5| 9| 2| 4| 9| 9| 0| 4| 7| 9| 0| 9| 9| 9| 8| 9|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |

    0.033                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM - cont                  |                                                                          |            |

                                           |                                                                          |            |

   Tongue                                  |                                                                          |   2        |

      Squamous Cell Papilloma              |                                                                          |          2 |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                            X                                             |          3 |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                         X        X                    X                  |          6 |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                            X     X                    X                  |          7 |

      Pheochromocytoma Malignant           |                                                                          |          1 |

      Pheochromocytoma Benign              |                                                             X            |          2 |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                                X         |          4 |

      Carcinoma                            |                                        X                                 |          1 |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                            X                                             |          3 |

      Pars Distalis, Adenoma               |    X        X     X     X                 X     X              X         |         21 |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      C-Cell, Adenoma                      |       X                       X                                          |          4 |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                             Page  28                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 7| 7| 7| 5| 5| 5| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7|            |

                             DAY ON TEST   | 3| 3| 3| 6| 1| 9| 3| 1| 3| 1| 2| 3| 4| 2| 2| 3| 9| 3| 2| 3| 2| 2| 2| 5| 2|            |

                                           | 1| 1| 1| 2| 8| 1| 0| 7| 0| 5| 9| 2| 4| 9| 9| 0| 4| 7| 9| 0| 9| 9| 9| 8| 9|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |

    0.033                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Adenoma                              |       X                 X  X     X     X                       X         |          8 |

      Carcinoma                            |    X     X                                X                              |          4 |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Granulosa Cell Tumor Malignant       |                                  X                                       |          1 |

      Leukemia Mononuclear                 |                         X                                                |          2 |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Deciduoma Benign                     |                                     X                                    |          1 |

      Leukemia Mononuclear                 |                                                                          |          1 |

      Polyp Stromal                        |       X  X  X     X  X                    X  X        X  X           X  X|         15 |

      Sarcoma Stromal                      |                                                    X                     |          2 |

                                           |__________________________________________________________________________|____________|

   Vagina                                  |                                                       +                  |   3        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |          X              X  X     X                    X                  |         10 |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              | +     +  +  +  +        +  +  +  +  +  +  +  +        +     +  +  +     +|  36        |

      Leukemia Mononuclear                 |                                                                          |          1 |

      Deep Cervical, Leukemia Mononuclear  |                                                                          |          1 |

      Iliac, Leukemia Mononuclear          |                            X                                             |          2 |

      Mediastinal, Leukemia Mononuclear    |          X              X  X     X                    X                  |          9 |

      Pancreatic, Leukemia Mononuclear     |                                                                          |          2 |

      Renal, Leukemia Mononuclear          |                            X                                             |          2 |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|  48        |

      Leukemia Mononuclear                 |          X              X  X                          X                  |          8 |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  29                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 7| 7| 7| 5| 5| 5| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7|            |

                             DAY ON TEST   | 3| 3| 3| 6| 1| 9| 3| 1| 3| 1| 2| 3| 4| 2| 2| 3| 9| 3| 2| 3| 2| 2| 2| 5| 2|            |

                                           | 1| 1| 1| 2| 8| 1| 0| 7| 0| 5| 9| 2| 4| 9| 9| 0| 4| 7| 9| 0| 9| 9| 9| 8| 9|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |

    0.033                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |          X              X  X     X                                       |          9 |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X  X  X              X  X     X                    X     X            |         13 |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  46        |

      Leukemia Mononuclear                 |          X                 X                                             |          4 |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                                          |          1 |

      Carcinoma                            |                            X                                             |          2 |

      Fibroadenoma                         | X  X     X              X     X        X  X                 X  X        X|         22 |

      Fibroadenoma, Multiple               |                                                                          |          4 |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Basal Cell Adenoma                   |                                                                          |          1 |

      Basal Cell Carcinoma                 |                                                                          |          1 |

      Keratoacanthoma                      |                   X                                                      |          1 |

      Subcutaneous Tissue, Fibroma         | X                                                     X  X               |          5 |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Skeletal Muscle                         |                +                                                         |   1        |

      Rhabdomyosarcoma                     |                X                                                         |          1 |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  30                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 7| 7| 7| 5| 5| 5| 7| 6| 7| 7| 7| 5| 4| 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 6| 7|            |

                             DAY ON TEST   | 3| 3| 3| 6| 1| 9| 3| 1| 3| 1| 2| 3| 4| 2| 2| 3| 9| 3| 2| 3| 2| 2| 2| 5| 2|            |

                                           | 1| 1| 1| 2| 8| 1| 0| 7| 0| 5| 9| 2| 4| 9| 9| 0| 4| 7| 9| 0| 9| 9| 9| 8| 9|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|     A      |

    0.033                                  | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM - cont                     |                                                                          |            |

                                           |                                                                          |            |

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Granular Cell Tumor Malignant        |                                                                         X|          1 |

      Leukemia Mononuclear                 |                            X                                             |          1 |

                                           |__________________________________________________________________________|____________|

   Peripheral Nerve                        |                                                 +                        |   1        |

                                           |__________________________________________________________________________|____________|

   Spinal Cord                             |                                                 +                        |   1        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X     X              X  X                          X                  |          6 |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X                    X  X     X                                       |          8 |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                            X                                             |          2 |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X  X  X              X  X     X                    X     X            |         13 |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  31                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|             

                             DAY ON TEST   | 0| 2| 2| 2| 2| 2| 2| 1| 6| 2| 9| 6| 3| 3| 1| 3| 3| 3| 0| 3| 3| 4| 3| 5| 3|             

                                           | 7| 9| 9| 9| 9| 9| 9| 8| 4| 9| 1| 8| 0| 0| 5| 0| 0| 0| 7| 0| 0| 6| 0| 1| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             

    0.1                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 ALIMENTARY SYSTEM                         |                                                                          |             

                                           |__________________________________________________________________________|             

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             

                                           |__________________________________________________________________________|             

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X     X           X                                X                 X  X|             

                                           |__________________________________________________________________________|             

   Mesentery                               |                   +              +  +  +     +     +        +     +  +   |             

                                           |__________________________________________________________________________|             

   Oral Mucosa                             |                            +                                      +      |             

      Squamous Cell Carcinoma              |                            X                                             |             

      Squamous Cell Papilloma              |                                                                   X      |             

                                           |__________________________________________________________________________|             

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

                                           |__________________________________________________________________________|             

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

                                           |__________________________________________________________________________|             

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                         X|             

                                           |__________________________________________________________________________|             

   Tooth                                   |                            +                                             |             

 _____________________________________________________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  32                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|             

                             DAY ON TEST   | 0| 2| 2| 2| 2| 2| 2| 1| 6| 2| 9| 6| 3| 3| 1| 3| 3| 3| 0| 3| 3| 4| 3| 5| 3|             

                                           | 7| 9| 9| 9| 9| 9| 9| 8| 4| 9| 1| 8| 0| 0| 5| 0| 0| 0| 7| 0| 0| 6| 0| 1| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             

    0.1                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 CARDIOVASCULAR SYSTEM                     |                                                                          |             

                                           |__________________________________________________________________________|             

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                         X|             

 _____________________________________________________________________________________________________________________|             

 ENDOCRINE SYSTEM                          |                                                                          |             

                                           |__________________________________________________________________________|             

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |    X                                                                     |             

      Leukemia Mononuclear                 | X                                                                    X  X|             

                                           |__________________________________________________________________________|             

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X                                                                       X|             

      Pheochromocytoma Benign              |                   X                                                      |             

                                           |__________________________________________________________________________|             

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X                                                                       X|             

      Pars Distalis, Adenoma               | X  X  X  X  X        X  X     X              X  X           X            |             

      Pars Intermedia, Adenoma             |                                                                          |             

                                           |__________________________________________________________________________|             

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      C-Cell, Adenoma                      |    X              X        X                 X           X               |             

 _____________________________________________________________________________________________________________________|             

 GENERAL BODY SYSTEM                       |                                                                          |             

                                           |__________________________________________________________________________|             

   Peritoneum                              |                                                       +                  |             

      Mesothelioma Malignant               |                                                       X                  |             

 _____________________________________________________________________________________________________________________|             

 GENITAL SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             

      Adenoma                              |    X  X  X     X              X                    X                 X   |             

      Carcinoma                            |             X     X                       X                              |             

      Bilateral, Adenoma                   |                      X                                                   |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  33                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|             

                             DAY ON TEST   | 0| 2| 2| 2| 2| 2| 2| 1| 6| 2| 9| 6| 3| 3| 1| 3| 3| 3| 0| 3| 3| 4| 3| 5| 3|             

                                           | 7| 9| 9| 9| 9| 9| 9| 8| 4| 9| 1| 8| 0| 0| 5| 0| 0| 0| 7| 0| 0| 6| 0| 1| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             

    0.1                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 GENITAL SYSTEM - cont                     |                                                                          |             

                                           |                                                                          |             

                                           |__________________________________________________________________________|             

   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Granulosa Cell Tumor Malignant       |    X                                                                     |             

      Leukemia Mononuclear                 |                                                                          |             

      Mesothelioma Malignant, Metastatic,  |                                                                          |             

           Peritoneum                      |                                                       X                  |             

                                           |__________________________________________________________________________|             

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Polyp Stromal                        |    X                                X  X                    X  X     X   |             

      Polyp Stromal, Multiple              |                                                                   X      |             

      Sarcoma Stromal                      |          X                                                     X         |             

                                           |__________________________________________________________________________|             

   Vagina                                  |                                           M           +                  |             

      Sarcoma Stromal, Metastatic, Uterus  |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 HEMATOPOIETIC SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X                 X                                X                 X  X|             

                                           |__________________________________________________________________________|             

   Lymph Node                              | +  +              +  +              +        +                    +  +   |             

      Mediastinal, Leukemia Mononuclear    | X                 X                                                  X   |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X                 X                                X                 X   |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X                                                                       X|             

                                           |__________________________________________________________________________|             

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X     X           X              X                 X                 X  X|             

                                           |__________________________________________________________________________|             

   Thymus                                  | M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 INTEGUMENTARY SYSTEM                      |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  34                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|             

                             DAY ON TEST   | 0| 2| 2| 2| 2| 2| 2| 1| 6| 2| 9| 6| 3| 3| 1| 3| 3| 3| 0| 3| 3| 4| 3| 5| 3|             

                                           | 7| 9| 9| 9| 9| 9| 9| 8| 4| 9| 1| 8| 0| 0| 5| 0| 0| 0| 7| 0| 0| 6| 0| 1| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             

    0.1                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 INTEGUMENTARY SYSTEM - cont               |                                                                          |             

                                           |                                                                          |             

                                           |__________________________________________________________________________|             

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                               X                                          |             

      Fibroadenoma                         |          X  X  X     X  X              X  X     X        X     X  X     X|             

      Fibroadenoma, Multiple               |                               X  X                 X        X            |             

                                           |__________________________________________________________________________|             

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Subcutaneous Tissue, Fibroma         |             X                             X                             X|             

 _____________________________________________________________________________________________________________________|             

 MUSCULOSKELETAL SYSTEM                    |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Skeletal Muscle                         |                                                       +                  |             

      Leukemia Mononuclear                 |                                                                          |             

      Mesothelioma Malignant, Metastatic,  |                                                                          |             

           Peritoneum                      |                                                       X                  |             

 _____________________________________________________________________________________________________________________|             

 NERVOUS SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Glioma Malignant                     |                                                                          |             

      Leukemia Mononuclear                 |                                                                         X|             

 _____________________________________________________________________________________________________________________|             

 RESPIRATORY SYSTEM                        |                                                                          |             

                                           |__________________________________________________________________________|             

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Alveolar/Bronchiolar Adenoma         |                   X                                                      |             

      Leukemia Mononuclear                 | X                                                                    X  X|             

                                           |__________________________________________________________________________|             

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 SPECIAL SENSES SYSTEM                     |                                                                          |             

    None                                   |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  35                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 6| 7| 6| 6|             

                             DAY ON TEST   | 0| 2| 2| 2| 2| 2| 2| 1| 6| 2| 9| 6| 3| 3| 1| 3| 3| 3| 0| 3| 3| 4| 3| 5| 3|             

                                           | 7| 9| 9| 9| 9| 9| 9| 8| 4| 9| 1| 8| 0| 0| 5| 0| 0| 0| 7| 0| 0| 6| 0| 1| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             

    0.1                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 URINARY SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X                                                                    X  X|             

                                           |__________________________________________________________________________|             

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

 SYSTEMIC LESIONS                          |                                                                          |             

                                            __________________________________________________________________________|             

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 | X     X           X              X                 X                 X  X|             

      Mesothelioma Malignant               |                                                       X                  |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  36                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 6| 4| 6| 5| 7| 2| 7| 6| 7| 2| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5|            |

                             DAY ON TEST   | 4| 1| 5| 6| 6| 2| 9| 2| 5| 1| 5| 7| 8| 2| 3| 3| 3| 3| 3| 0| 7| 3| 5| 8| 5|            |

                                           | 2| 8| 1| 0| 1| 9| 3| 9| 0| 0| 2| 8| 2| 6| 8| 1| 1| 1| 1| 7| 8| 1| 8| 0| 2|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |

    0.1                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | A  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | A  +  +  +  +  +  A  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  A|  43        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | A  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  A|  43        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 | X  X  X     X  X                 X        X     X                 X  X   |         16 |

                                           |__________________________________________________________________________|____________|

   Mesentery                               |          +                 +        +     +                    +         |  14        |

                                           |__________________________________________________________________________|____________|

   Oral Mucosa                             |                                                                          |   2        |

      Squamous Cell Carcinoma              |                                                                          |          1 |

      Squamous Cell Papilloma              |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |

      Leukemia Mononuclear                 |             X                                                        X   |          2 |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Leukemia Mononuclear                 |                                                                      X   |          1 |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  37                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 6| 4| 6| 5| 7| 2| 7| 6| 7| 2| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5|            |

                             DAY ON TEST   | 4| 1| 5| 6| 6| 2| 9| 2| 5| 1| 5| 7| 8| 2| 3| 3| 3| 3| 3| 0| 7| 3| 5| 8| 5|            |

                                           | 2| 8| 1| 0| 1| 9| 3| 9| 0| 0| 2| 8| 2| 6| 8| 1| 1| 1| 1| 7| 8| 1| 8| 0| 2|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |

    0.1                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM - cont                  |                                                                          |            |

                                           |                                                                          |            |

      Leukemia Mononuclear                 |             X                                                            |          2 |

                                           |__________________________________________________________________________|____________|

   Tooth                                   |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X                                                                 X   |          3 |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                                          |          1 |

      Leukemia Mononuclear                 |    X  X     X                             X     X                 X  X   |         10 |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X  X     X                             X     X                        |          7 |

      Pheochromocytoma Benign              |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +|  46        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |

      Leukemia Mononuclear                 |             X                             X                       X      |          5 |

      Pars Distalis, Adenoma               |          X  X                    X              X  X        X            |         17 |

      Pars Intermedia, Adenoma             |                                              X                           |          1 |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      C-Cell, Adenoma                      |                                     X                                    |          6 |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  38                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 6| 4| 6| 5| 7| 2| 7| 6| 7| 2| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5|            |

                             DAY ON TEST   | 4| 1| 5| 6| 6| 2| 9| 2| 5| 1| 5| 7| 8| 2| 3| 3| 3| 3| 3| 0| 7| 3| 5| 8| 5|            |

                                           | 2| 8| 1| 0| 1| 9| 3| 9| 0| 0| 2| 8| 2| 6| 8| 1| 1| 1| 1| 7| 8| 1| 8| 0| 2|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |

    0.1                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 GENERAL BODY SYSTEM - cont                |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Peritoneum                              |                                                                          |   1        |

      Mesothelioma Malignant               |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

      Adenoma                              |                X                                      X                  |          9 |

      Carcinoma                            |                                                                          |          3 |

      Bilateral, Adenoma                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Granulosa Cell Tumor Malignant       |                                                                          |          1 |

      Leukemia Mononuclear                 |                                  X                                       |          1 |

      Mesothelioma Malignant, Metastatic,  |                                                                          |            |

           Peritoneum                      |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Polyp Stromal                        |             X  X     X              X                          X         |         11 |

      Polyp Stromal, Multiple              |                                                                          |          1 |

      Sarcoma Stromal                      |                                     X                    X               |          4 |

                                           |__________________________________________________________________________|____________|

   Vagina                                  |                                     +     +                 +            |   4        |

      Sarcoma Stromal, Metastatic, Uterus  |                                     X                                    |          1 |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X  X     X                    X        X                       X  X   |         12 |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              |    +  +        +                       +  +        +  +  +     +  +     +|  19        |

      Mediastinal, Leukemia Mononuclear    |       X                                                           X      |          5 |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  39                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 6| 4| 6| 5| 7| 2| 7| 6| 7| 2| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5|            |

                             DAY ON TEST   | 4| 1| 5| 6| 6| 2| 9| 2| 5| 1| 5| 7| 8| 2| 3| 3| 3| 3| 3| 0| 7| 3| 5| 8| 5|            |

                                           | 2| 8| 1| 0| 1| 9| 3| 9| 0| 0| 2| 8| 2| 6| 8| 1| 1| 1| 1| 7| 8| 1| 8| 0| 2|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |

    0.1                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |             X                    X        X                       X  X   |          9 |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |

      Leukemia Mononuclear                 |             X                    X        X                       X  X   |          7 |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 | X  X  X     X  X                 X        X     X              X  X  X   |         18 |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

      Leukemia Mononuclear                 |             X                                                        X   |          2 |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                                          |          1 |

      Fibroadenoma                         |                      X     X        X                 X  X               |         17 |

      Fibroadenoma, Multiple               |                X        X                 X                              |          7 |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Subcutaneous Tissue, Fibroma         |                                                                          |          3 |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Skeletal Muscle                         |    +                                                                     |   2        |

      Leukemia Mononuclear                 |    X                                                                     |          1 |

      Mesothelioma Malignant, Metastatic,  |                                                                          |            |

           Peritoneum                      |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  40                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 6| 4| 6| 5| 7| 2| 7| 6| 7| 2| 6| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 6| 6| 5|            |

                             DAY ON TEST   | 4| 1| 5| 6| 6| 2| 9| 2| 5| 1| 5| 7| 8| 2| 3| 3| 3| 3| 3| 0| 7| 3| 5| 8| 5|            |

                                           | 2| 8| 1| 0| 1| 9| 3| 9| 0| 0| 2| 8| 2| 6| 8| 1| 1| 1| 1| 7| 8| 1| 8| 0| 2|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|     A      |

    0.1                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Glioma Malignant                     |                               X                                          |          1 |

      Leukemia Mononuclear                 |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Alveolar/Bronchiolar Adenoma         |                            X                                      X      |          3 |

      Leukemia Mononuclear                 |    X  X     X                    X        X                       X  X   |         10 |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X  X     X                                                        X   |          7 |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  48        |

      Leukemia Mononuclear                 |                                  X                                   X   |          2 |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 | X  X  X     X  X                 X        X     X              X  X  X   |         18 |

      Mesothelioma Malignant               |                                                                          |          1 |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  41                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 5| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7|             

                             DAY ON TEST   | 2| 3| 3| 5| 8| 3| 7| 2| 9| 3| 2| 5| 2| 2| 2| 3| 3| 3| 3| 5| 9| 3| 3| 8| 3|             

                                           | 4| 0| 0| 4| 7| 0| 0| 9| 0| 0| 9| 1| 9| 9| 9| 1| 1| 1| 0| 7| 7| 1| 1| 6| 1|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             

    0.33                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 ALIMENTARY SYSTEM                         |                                                                          |             

                                           |__________________________________________________________________________|             

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Lymphoma Malignant                   |                                  X                                       |             

                                           |__________________________________________________________________________|             

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Cholangiocarcinoma                   |                                                                          |             

      Hemangiosarcoma                      | X                                                  X                     |             

      Hepatocellular Carcinoma             |                                                 X                        |             

      Hepatocellular Adenoma, Multiple     |                                                                          |             

      Leukemia Mononuclear                 |          X  X        X                                X     X        X   |             

      Lymphoma Malignant                   |                                  X                                       |             

                                           |__________________________________________________________________________|             

   Mesentery                               |       +     +                       +                       +  +     +   |             

      Leukemia Mononuclear                 |                                                                          |             

      Sarcoma Stromal, Metastatic, Uterus  |                                     X                                    |             

                                           |__________________________________________________________________________|             

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

                                           |__________________________________________________________________________|             

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

                                           |__________________________________________________________________________|             

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  42                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 5| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7|             

                             DAY ON TEST   | 2| 3| 3| 5| 8| 3| 7| 2| 9| 3| 2| 5| 2| 2| 2| 3| 3| 3| 3| 5| 9| 3| 3| 8| 3|             

                                           | 4| 0| 0| 4| 7| 0| 0| 9| 0| 0| 9| 1| 9| 9| 9| 1| 1| 1| 0| 7| 7| 1| 1| 6| 1|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             

    0.33                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 CARDIOVASCULAR SYSTEM                     |                                                                          |             

                                           |__________________________________________________________________________|             

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                       X                  |             

 _____________________________________________________________________________________________________________________|             

 ENDOCRINE SYSTEM                          |                                                                          |             

                                           |__________________________________________________________________________|             

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                                                                          |             

      Leukemia Mononuclear                 |          X  X                                                        X   |             

                                           |__________________________________________________________________________|             

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X  X                                               X            |             

      Pheochromocytoma Benign              |                                                 X                        |             

                                           |__________________________________________________________________________|             

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                                                                         X|             

                                           |__________________________________________________________________________|             

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |             X                                                            |             

      Pars Distalis, Adenoma               | X  X           X  X  X  X           X  X     X  X  X        X  X        X|             

                                           |__________________________________________________________________________|             

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      C-Cell, Adenoma                      |                   X                             X        X              X|             

 _____________________________________________________________________________________________________________________|             

 GENERAL BODY SYSTEM                       |                                                                          |             

    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 GENITAL SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Clitoral Gland                          | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                                                                   X  X   |             

      Carcinoma                            |                                                                          |             

      Bilateral, Adenoma                   |                                                                          |             

                                           |__________________________________________________________________________|             

   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  43                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 5| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7|             

                             DAY ON TEST   | 2| 3| 3| 5| 8| 3| 7| 2| 9| 3| 2| 5| 2| 2| 2| 3| 3| 3| 3| 5| 9| 3| 3| 8| 3|             

                                           | 4| 0| 0| 4| 7| 0| 0| 9| 0| 0| 9| 1| 9| 9| 9| 1| 1| 1| 0| 7| 7| 1| 1| 6| 1|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             

    0.33                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 GENITAL SYSTEM - cont                     |                                                                          |             

                                           |                                                                          |             

      Lymphoma Malignant                   |                                  X                                       |             

                                           |__________________________________________________________________________|             

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Polyp Stromal                        | X  X           X           X  X                                   X      |             

      Sarcoma Stromal                      |                                     X                                    |             

                                           |__________________________________________________________________________|             

   Vagina                                  |             +                    +  +                                    |             

 _____________________________________________________________________________________________________________________|             

 HEMATOPOIETIC SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X  X        X                                X     X            |             

      Lymphoma Malignant                   |                                  X                                       |             

                                           |__________________________________________________________________________|             

   Lymph Node                              |             +     +  +  +  +  +  +  +                       +  +  +  +  +|             

      Iliac, Leukemia Mononuclear          |                                                                          |             

      Mediastinal, Leukemia Mononuclear    |             X        X                                                   |             

      Mediastinal, Lymphoma Malignant      |                                  X                                       |             

      Pancreatic, Leukemia Mononuclear     |             X        X                                                   |             

      Pancreatic, Lymphoma Malignant       |                                  X                                       |             

      Renal, Leukemia Mononuclear          |             X                                                            |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X  X        X                                X     X        X   |             

      Lymphoma Malignant                   |                                  X                                       |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X  X                                         X     X            |             

      Lymphoma Malignant                   |                                  X                                       |             

                                           |__________________________________________________________________________|             

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X  X        X                                X     X        X   |             

      Lymphoma Malignant                   |                                  X                                       |             

                                           |__________________________________________________________________________|             

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |             X                                         X                  |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  44                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 5| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7|             

                             DAY ON TEST   | 2| 3| 3| 5| 8| 3| 7| 2| 9| 3| 2| 5| 2| 2| 2| 3| 3| 3| 3| 5| 9| 3| 3| 8| 3|             

                                           | 4| 0| 0| 4| 7| 0| 0| 9| 0| 0| 9| 1| 9| 9| 9| 1| 1| 1| 0| 7| 7| 1| 1| 6| 1|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             

    0.33                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 INTEGUMENTARY SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                X                                                         |             

      Carcinoma                            |                X                                X                        |             

      Fibroadenoma                         |       X  X        X     X  X           X  X     X        X     X  X      |             

      Fibroadenoma, Multiple               |                                                                          |             

                                           |__________________________________________________________________________|             

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 MUSCULOSKELETAL SYSTEM                    |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 NERVOUS SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Peripheral Nerve                        |                   +              +                                       |             

                                           |__________________________________________________________________________|             

   Spinal Cord                             |                   +              +                                       |             

 _____________________________________________________________________________________________________________________|             

 RESPIRATORY SYSTEM                        |                                                                          |             

                                           |__________________________________________________________________________|             

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Alveolar/Bronchiolar Adenoma         |                            X                                             |             

      Alveolar/Bronchiolar Carcinoma       |                                                                          |             

      Hemangiosarcoma, Metastatic, Liver   | X                                                                        |             

      Leukemia Mononuclear                 |          X           X                                X     X        X   |             

                                           |__________________________________________________________________________|             

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 SPECIAL SENSES SYSTEM                     |                                                                          |             

    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 URINARY SYSTEM                            |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  45                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 5| 7| 7| 6| 5| 7| 5| 7| 5| 7| 7| 4| 7| 7| 7| 7| 7| 7| 6| 6| 6| 7| 7| 6| 7|             

                             DAY ON TEST   | 2| 3| 3| 5| 8| 3| 7| 2| 9| 3| 2| 5| 2| 2| 2| 3| 3| 3| 3| 5| 9| 3| 3| 8| 3|             

                                           | 4| 0| 0| 4| 7| 0| 0| 9| 0| 0| 9| 1| 9| 9| 9| 1| 1| 1| 0| 7| 7| 1| 1| 6| 1|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             

    0.33                                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 URINARY SYSTEM - cont                     |                                                                          |             

                                           |                                                                          |             

                                           |__________________________________________________________________________|             

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X  X                                         X                  |             

                                           |__________________________________________________________________________|             

   Ureter                                  |                                                                          |             

                                           |__________________________________________________________________________|             

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

 SYSTEMIC LESIONS                          |                                                                          |             

                                            __________________________________________________________________________|             

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X  X        X                                X     X        X   |             

      Lymphoma Malignant                   |                                  X                                       |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  46                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 5| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6|            |

                             DAY ON TEST   | 8| 2| 2| 7| 2| 8| 2| 2| 2| 6| 3| 5| 7| 3| 3| 5| 5| 3| 1| 8| 2| 2| 2| 2| 0|            |

                                           | 1| 9| 9| 6| 9| 0| 9| 9| 9| 3| 0| 8| 1| 0| 0| 4| 6| 0| 9| 6| 9| 9| 9| 9| 2|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |

    0.33                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Cholangiocarcinoma                   |                               X                                          |          1 |

      Hemangiosarcoma                      |                                     X                                    |          3 |

      Hepatocellular Carcinoma             |                                                                          |          1 |

      Hepatocellular Adenoma, Multiple     |                                                                   X      |          1 |

      Leukemia Mononuclear                 | X                 X  X     X        X  X     X        X  X     X  X     X|         18 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Mesentery                               |       +  +     +           +                          +     +           +|  13        |

      Leukemia Mononuclear                 |                                                                         X|          1 |

      Sarcoma Stromal, Metastatic, Uterus  |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                         X|          1 |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  47                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 5| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6|            |

                             DAY ON TEST   | 8| 2| 2| 7| 2| 8| 2| 2| 2| 6| 3| 5| 7| 3| 3| 5| 5| 3| 1| 8| 2| 2| 2| 2| 0|            |

                                           | 1| 9| 9| 6| 9| 0| 9| 9| 9| 3| 0| 8| 1| 0| 0| 4| 6| 0| 9| 6| 9| 9| 9| 9| 2|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |

    0.33                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM - cont                  |                                                                          |            |

                                           |                                                                          |            |

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Leukemia Mononuclear                 |                                                                         X|          1 |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                        X                                 |          1 |

      Leukemia Mononuclear                 | X                          X                          X  X              X|          8 |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                       X                 X|          5 |

      Pheochromocytoma Benign              |                                     X                    X               |          3 |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                         X|          2 |

      Pars Distalis, Adenoma               |                      X        X        X  X  X  X  X     X     X        X|         24 |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      C-Cell, Adenoma                      | X  X        X           X        X           X                    X      |         11 |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                             Page  48                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 5| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6|            |

                             DAY ON TEST   | 8| 2| 2| 7| 2| 8| 2| 2| 2| 6| 3| 5| 7| 3| 3| 5| 5| 3| 1| 8| 2| 2| 2| 2| 0|            |

                                           | 1| 9| 9| 6| 9| 0| 9| 9| 9| 3| 0| 8| 1| 0| 0| 4| 6| 0| 9| 6| 9| 9| 9| 9| 2|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |

    0.33                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Adenoma                              |             X                                                            |          3 |

      Carcinoma                            |    X              X                                                      |          2 |

      Bilateral, Adenoma                   |                                                                   X      |          1 |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Polyp Stromal                        |                                                          X           X  X|          9 |

      Sarcoma Stromal                      |                            X                                             |          2 |

                                           |__________________________________________________________________________|____________|

   Vagina                                  |                            +                          +                  |   5        |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 | X                 X  X     X        X                 X  X              X|         13 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              |    +                          +           +           +  +  +     +     +|  21        |

      Iliac, Leukemia Mononuclear          |                                                          X               |          1 |

      Mediastinal, Leukemia Mononuclear    |                                                                         X|          3 |

      Mediastinal, Lymphoma Malignant      |                                                                          |          1 |

      Pancreatic, Leukemia Mononuclear     |                                                          X              X|          4 |

      Pancreatic, Lymphoma Malignant       |                                                                          |          1 |

      Renal, Leukemia Mononuclear          |                                                          X               |          2 |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 | X                    X                                X  X              X|         11 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  49                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 5| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6|            |

                             DAY ON TEST   | 8| 2| 2| 7| 2| 8| 2| 2| 2| 6| 3| 5| 7| 3| 3| 5| 5| 3| 1| 8| 2| 2| 2| 2| 0|            |

                                           | 1| 9| 9| 6| 9| 0| 9| 9| 9| 3| 0| 8| 1| 0| 0| 4| 6| 0| 9| 6| 9| 9| 9| 9| 2|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |

    0.33                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Leukemia Mononuclear                 |                                                          X              X|          6 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 | X                 X  X     X        X  X     X        X  X        X     X|         17 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                         X|          3 |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  49        |

      Adenoma                              |                                                                          |          1 |

      Carcinoma                            |                         X                                X               |          4 |

      Fibroadenoma                         |          X     X  X  X        X                          X  X            |         18 |

      Fibroadenoma, Multiple               |       X                                         X  X           X     X   |          5 |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Peripheral Nerve                        |                                                                          |   2        |

                                           |__________________________________________________________________________|____________|

   Spinal Cord                             |                                                                          |   2        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  50                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 5| 7| 7| 5| 7| 6| 7| 7| 7| 4| 7| 6| 6| 7| 7| 6| 6| 7| 6| 6| 7| 7| 7| 7| 6|            |

                             DAY ON TEST   | 8| 2| 2| 7| 2| 8| 2| 2| 2| 6| 3| 5| 7| 3| 3| 5| 5| 3| 1| 8| 2| 2| 2| 2| 0|            |

                                           | 1| 9| 9| 6| 9| 0| 9| 9| 9| 3| 0| 8| 1| 0| 0| 4| 6| 0| 9| 6| 9| 9| 9| 9| 2|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|     A      |

    0.33                                   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Alveolar/Bronchiolar Adenoma         |                                                             X            |          2 |

      Alveolar/Bronchiolar Carcinoma       |                                           X                              |          1 |

      Hemangiosarcoma, Metastatic, Liver   |                                                                          |          1 |

      Leukemia Mononuclear                 | X                                                     X  X              X|          9 |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 | X                                                                       X|          5 |

                                           |__________________________________________________________________________|____________|

   Ureter                                  |                            +                                             |   1        |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                      X                                                   |          1 |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 | X                 X  X     X        X  X     X        X  X     X  X     X|         18 |

      Lymphoma Malignant                   |                                                                          |          1 |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  51                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 4| 5| 5| 5| 4| 4| 5| 4| 5| 5| 5| 4| 3| 5| 4| 4| 6| 3| 5| 4| 6| 5| 3| 4| 4|             

                             DAY ON TEST   | 8| 5| 8| 2| 6| 6| 0| 2| 4| 2| 8| 6| 9| 7| 0| 7| 6| 5| 2| 7| 0| 2| 5| 5| 4|             

                                           | 8| 2| 1| 8| 1| 9| 3| 3| 1| 2| 7| 1| 3| 3| 0| 6| 8| 0| 7| 2| 8| 8| 2| 9| 7|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             

    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 ALIMENTARY SYSTEM                         |                                                                          |             

                                           |__________________________________________________________________________|             

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             

                                           |__________________________________________________________________________|             

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Hemangiosarcoma                      | X  X  X                    X  X  X     X     X        X     X  X  X      |             

      Hemangiosarcoma, Multiple            |          X  X  X  X  X  X           X              X                     |             

      Hepatocellular Carcinoma             |                                        X                                 |             

      Hepatocellular Adenoma               |                            X                                             |             

      Leukemia Mononuclear                 |          X     X                          X     X        X     X  X  X   |             

      Lymphoma Malignant                   |                                                       X                  |             

                                           |__________________________________________________________________________|             

   Mesentery                               |    +                    +  +                                             |             

      Hemangiosarcoma, Metastatic, Liver   |    X                                                                     |             

                                           |__________________________________________________________________________|             

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Lymphoma Malignant                   |                                                       X                  |             

                                           |__________________________________________________________________________|             

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Lymphoma Malignant                   |                                                       X                  |             

 _____________________________________________________________________________________________________________________|             

 CARDIOVASCULAR SYSTEM                     |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  52                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 4| 5| 5| 5| 4| 4| 5| 4| 5| 5| 5| 4| 3| 5| 4| 4| 6| 3| 5| 4| 6| 5| 3| 4| 4|             

                             DAY ON TEST   | 8| 5| 8| 2| 6| 6| 0| 2| 4| 2| 8| 6| 9| 7| 0| 7| 6| 5| 2| 7| 0| 2| 5| 5| 4|             

                                           | 8| 2| 1| 8| 1| 9| 3| 3| 1| 2| 7| 1| 3| 3| 0| 6| 8| 0| 7| 2| 8| 8| 2| 9| 7|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             

    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             

                                           |                                                                          |             

                                           |__________________________________________________________________________|             

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                 X                        |             

 _____________________________________________________________________________________________________________________|             

 ENDOCRINE SYSTEM                          |                                                                          |             

                                           |__________________________________________________________________________|             

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X                                X     X                 X      |             

                                           |__________________________________________________________________________|             

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                           X     X                        |             

      Lymphoma Malignant                   |                                                       X                  |             

      Pheochromocytoma Benign              |                                                          X               |             

                                           |__________________________________________________________________________|             

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

      Pars Distalis, Adenoma               |                                        X        X           X            |             

      Pars Intermedia, Adenoma             |                                                                          |             

                                           |__________________________________________________________________________|             

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Follicular Cell, Carcinoma           |                                                                      X   |             

 _____________________________________________________________________________________________________________________|             

 GENERAL BODY SYSTEM                       |                                                                          |             

    None                                   |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 GENITAL SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                   X                                                      |             

                                           |__________________________________________________________________________|             

   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Lymphoma Malignant                   |                                                       X                  |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  53                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 4| 5| 5| 5| 4| 4| 5| 4| 5| 5| 5| 4| 3| 5| 4| 4| 6| 3| 5| 4| 6| 5| 3| 4| 4|             

                             DAY ON TEST   | 8| 5| 8| 2| 6| 6| 0| 2| 4| 2| 8| 6| 9| 7| 0| 7| 6| 5| 2| 7| 0| 2| 5| 5| 4|             

                                           | 8| 2| 1| 8| 1| 9| 3| 3| 1| 2| 7| 1| 3| 3| 0| 6| 8| 0| 7| 2| 8| 8| 2| 9| 7|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             

    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 GENITAL SYSTEM - cont                     |                                                                          |             

                                           |                                                                          |             

                                           |__________________________________________________________________________|             

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Polyp Stromal                        |    X                             X                                      X|             

 _____________________________________________________________________________________________________________________|             

 HEMATOPOIETIC SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X                                      X                        |             

      Lymphoma Malignant                   |                                                       X                  |             

                                           |__________________________________________________________________________|             

   Lymph Node                              | +  +  +  +  +     +  +  +     +  +  +  +        +     +  +  +  +  +  +  +|             

      Mediastinal, Hemangiosarcoma,        |                                                                          |             

          Metastatic, Liver                |                                                                X         |             

      Mediastinal, Leukemia Mononuclear    |          X                                      X                        |             

      Mediastinal, Lymphoma Malignant      |                                                       X                  |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                           X     X                        |             

      Lymphoma Malignant                   |                                                       X                  |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X                                      X     X                        |             

      Lymphoma Malignant                   |                                                       X                  |             

                                           |__________________________________________________________________________|             

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X     X                          X     X        X     X  X  X   |             

      Lymphoma Malignant                   |                                                       X                  |             

                                           |__________________________________________________________________________|             

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

      Lymphoma Malignant                   |                                                       X                  |             

 _____________________________________________________________________________________________________________________|             

 INTEGUMENTARY SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             

      Carcinoma                            |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  54                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 4| 5| 5| 5| 4| 4| 5| 4| 5| 5| 5| 4| 3| 5| 4| 4| 6| 3| 5| 4| 6| 5| 3| 4| 4|             

                             DAY ON TEST   | 8| 5| 8| 2| 6| 6| 0| 2| 4| 2| 8| 6| 9| 7| 0| 7| 6| 5| 2| 7| 0| 2| 5| 5| 4|             

                                           | 8| 2| 1| 8| 1| 9| 3| 3| 1| 2| 7| 1| 3| 3| 0| 6| 8| 0| 7| 2| 8| 8| 2| 9| 7|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             

    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 INTEGUMENTARY SYSTEM - cont               |                                                                          |             

                                           |                                                                          |             

      Fibroadenoma                         |             X                                                            |             

                                           |__________________________________________________________________________|             

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Subcutaneous Tissue, Fibroma         |                                                                         X|             

 _____________________________________________________________________________________________________________________|             

 MUSCULOSKELETAL SYSTEM                    |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Skeletal Muscle                         | +                       +                    +                           |             

 _____________________________________________________________________________________________________________________|             

 NERVOUS SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X                                                        X      |             

                                           |__________________________________________________________________________|             

   Peripheral Nerve                        |       +              +                                +  +               |             

                                           |__________________________________________________________________________|             

   Spinal Cord                             |       +              +                                +  +               |             

 _____________________________________________________________________________________________________________________|             

 RESPIRATORY SYSTEM                        |                                                                          |             

                                           |__________________________________________________________________________|             

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Hemangiosarcoma                      |                                                                          |             

      Hemangiosarcoma, Metastatic, Liver   | X  X     X        X  X        X                       X     X  X  X      |             

      Leukemia Mononuclear                 |          X                                      X                 X      |             

      Lymphoma Malignant                   |                                                       X                  |             

                                           |__________________________________________________________________________|             

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 SPECIAL SENSES SYSTEM                     |                                                                          |             

                                           |__________________________________________________________________________|             

   Eye                                     |                                                                          |             

 _____________________________________________________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  55                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 4| 5| 5| 5| 4| 4| 5| 4| 5| 5| 5| 4| 3| 5| 4| 4| 6| 3| 5| 4| 6| 5| 3| 4| 4|             

                             DAY ON TEST   | 8| 5| 8| 2| 6| 6| 0| 2| 4| 2| 8| 6| 9| 7| 0| 7| 6| 5| 2| 7| 0| 2| 5| 5| 4|             

                                           | 8| 2| 1| 8| 1| 9| 3| 3| 1| 2| 7| 1| 3| 3| 0| 6| 8| 0| 7| 2| 8| 8| 2| 9| 7|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             

    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 URINARY SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |          X                                      X                        |             

      Lymphoma Malignant                   |                                                       X                  |             

                                           |__________________________________________________________________________|             

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 __________________________________________|__________________________________________________________________________|             

 SYSTEMIC LESIONS                          |                                                                          |             

                                            __________________________________________________________________________|             

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |    X     X     X                          X     X        X     X  X  X   |             

      Lymphoma Malignant                   |                                                       X                  |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  56                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 5| 4| 5| 5| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 4| 4| 5| 6| 4| 5|            |

                             DAY ON TEST   | 1| 9| 2| 0| 1| 7| 6| 5| 5| 4| 8| 2| 7| 4| 0| 7| 4| 6| 5| 0| 0| 5| 5| 3| 8|            |

                                           | 8| 1| 6| 6| 6| 0| 0| 2| 2| 2| 7| 8| 8| 0| 9| 5| 8| 9| 2| 7| 5| 6| 8| 4| 7|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     A      |

    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Hemangiosarcoma                      | X     X  X     X  X  X     X  X        X     X     X           X     X   |         25 |

      Hemangiosarcoma, Multiple            |             X                             X                 X     X     X|         13 |

      Hepatocellular Carcinoma             |                                                                          |          1 |

      Hepatocellular Adenoma               | X  X  X     X              X                       X                     |          7 |

      Leukemia Mononuclear                 |       X           X              X                    X  X               |         13 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Mesentery                               |                                                       +                 +|   5        |

      Hemangiosarcoma, Metastatic, Liver   |                                                                         X|          2 |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  57                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 5| 4| 5| 5| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 4| 4| 5| 6| 4| 5|            |

                             DAY ON TEST   | 1| 9| 2| 0| 1| 7| 6| 5| 5| 4| 8| 2| 7| 4| 0| 7| 4| 6| 5| 0| 0| 5| 5| 3| 8|            |

                                           | 8| 1| 6| 6| 6| 0| 0| 2| 2| 2| 7| 8| 8| 0| 9| 5| 8| 9| 2| 7| 5| 6| 8| 4| 7|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     A      |

    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM - cont                  |                                                                          |            |

                                           |                                                                          |            |

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Lymphoma Malignant                   |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |       X           X              X                                       |          7 |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |       X           X                                                      |          4 |

      Lymphoma Malignant                   |                                                                          |          1 |

      Pheochromocytoma Benign              |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Leukemia Mononuclear                 |                                  X                                       |          1 |

      Pars Distalis, Adenoma               |                      X     X                          X              X   |          7 |

      Pars Intermedia, Adenoma             |                                     X                                    |          1 |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Follicular Cell, Carcinoma           |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  58                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 5| 4| 5| 5| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 4| 4| 5| 6| 4| 5|            |

                             DAY ON TEST   | 1| 9| 2| 0| 1| 7| 6| 5| 5| 4| 8| 2| 7| 4| 0| 7| 4| 6| 5| 0| 0| 5| 5| 3| 8|            |

                                           | 8| 1| 6| 6| 6| 0| 0| 2| 2| 2| 7| 8| 8| 0| 9| 5| 8| 9| 2| 7| 5| 6| 8| 4| 7|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     A      |

    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                                   X      |          2 |

                                           |__________________________________________________________________________|____________|

   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Polyp Stromal                        |                            X                                      X      |          5 |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                   X              X                                       |          4 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              | +  +  +  +  +  +  +  +  +     +  +     +  +     +  +     +  +     +  +  +|  40        |

      Mediastinal, Hemangiosarcoma,        |                                                                          |            |

          Metastatic, Liver                |                                        X                                 |          2 |

      Mediastinal, Leukemia Mononuclear    |       X           X              X                                       |          5 |

      Mediastinal, Lymphoma Malignant      |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |       X           X                                                      |          4 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Leukemia Mononuclear                 |       X           X              X                                       |          6 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |       X           X              X                    X  X               |         13 |

      Lymphoma Malignant                   |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  59                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 5| 4| 5| 5| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 4| 4| 5| 6| 4| 5|            |

                             DAY ON TEST   | 1| 9| 2| 0| 1| 7| 6| 5| 5| 4| 8| 2| 7| 4| 0| 7| 4| 6| 5| 0| 0| 5| 5| 3| 8|            |

                                           | 8| 1| 6| 6| 6| 0| 0| 2| 2| 2| 7| 8| 8| 0| 9| 5| 8| 9| 2| 7| 5| 6| 8| 4| 7|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     A      |

    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Leukemia Mononuclear                 |                                  X                                       |          1 |

      Lymphoma Malignant                   |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Carcinoma                            |                         X                                                |          1 |

      Fibroadenoma                         |                                  X                    X                  |          3 |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Subcutaneous Tissue, Fibroma         |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Skeletal Muscle                         |                +     +        +                                          |   6        |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                  X                                       |          3 |

                                           |__________________________________________________________________________|____________|

   Peripheral Nerve                        |                                                          +               |   5        |

                                           |__________________________________________________________________________|____________|

   Spinal Cord                             |                                                          +               |   5        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  60                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 6| 5| 4| 5| 5| 4| 4| 5| 5| 5| 4| 5| 4| 4| 5| 4| 5| 5| 5| 4| 4| 5| 6| 4| 5|            |

                             DAY ON TEST   | 1| 9| 2| 0| 1| 7| 6| 5| 5| 4| 8| 2| 7| 4| 0| 7| 4| 6| 5| 0| 0| 5| 5| 3| 8|            |

                                           | 8| 1| 6| 6| 6| 0| 0| 2| 2| 2| 7| 8| 8| 0| 9| 5| 8| 9| 2| 7| 5| 6| 8| 4| 7|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|     A      |

    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 RESPIRATORY SYSTEM - cont                 |                                                                          |            |

                                           |                                                                          |            |

      Hemangiosarcoma                      |                                                 X                        |          1 |

      Hemangiosarcoma, Metastatic, Liver   | X           X     X                    X                    X        X  X|         17 |

      Leukemia Mononuclear                 |       X           X              X                                       |          6 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Eye                                     |                                              +                           |   1        |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                   X              X                                       |          4 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |       X           X              X                    X  X               |         14 |

      Lymphoma Malignant                   |                                                                          |          1 |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  61                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             

                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 ALIMENTARY SYSTEM                         |                                                                          |             

                                           |__________________________________________________________________________|             

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                                          |             

      Mesothelioma Malignant, Metastatic,  |                                                                          |             

           Peritoneum                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Mesentery                               | +     +  +        +                                            +     +   |             

                                           |__________________________________________________________________________|             

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Acinus, Adenoma                      |                                                                X         |             

                                           |__________________________________________________________________________|             

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 CARDIOVASCULAR SYSTEM                     |                                                                          |             

                                           |__________________________________________________________________________|             

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 ENDOCRINE SYSTEM                          |                                                                          |             

                                           |__________________________________________________________________________|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  62                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             

                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 ENDOCRINE SYSTEM - cont                   |                                                                          |             

                                           |                                                                          |             

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             

      Pheochromocytoma Benign              |                            X                                             |             

                                           |__________________________________________________________________________|             

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Parathyroid Gland                       | +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Pars Distalis, Adenoma               |                         X           X        X     X  X     X     X      |             

      Pars Distalis, Carcinoma             |                                                                          |             

                                           |__________________________________________________________________________|             

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      C-Cell, Adenoma                      |                            X                    X                        |             

      C-Cell, Carcinoma                    |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 GENERAL BODY SYSTEM                       |                                                                          |             

                                           |__________________________________________________________________________|             

   Peritoneum                              |             +                                      +        +            |             

      Mesothelioma Malignant               |             X                                      X        X            |             

 _____________________________________________________________________________________________________________________|             

 GENITAL SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Mesothelioma Malignant, Metastatic,  |                                                                          |             

           Peritoneum                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Adenoma                              |                                                    X                     |             

                                           |__________________________________________________________________________|             

   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Mesothelioma Malignant, Metastatic,  |                                                                          |             

           Peritoneum                      |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  63                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             

                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 GENITAL SYSTEM - cont                     |                                                                          |             

                                           |                                                                          |             

                                           |__________________________________________________________________________|             

   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Bilateral, Interstitial Cell, Adenoma|          X                       X              X              X     X   |             

      Interstitial Cell, Adenoma           |       X     X  X  X  X  X     X     X  X  X        X     X               |             

 _____________________________________________________________________________________________________________________|             

 HEMATOPOIETIC SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Lymph Node                              |    +        +  +                 +        +  +     +           +        +|             

                                           |__________________________________________________________________________|             

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                   X                                                      |             

                                           |__________________________________________________________________________|             

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Thymoma Benign                       |                                                          X               |             

 _____________________________________________________________________________________________________________________|             

 INTEGUMENTARY SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Keratoacanthoma                      |                      X                                                   |             

      Squamous Cell Papilloma              |                                                                          |             

      Subcutaneous Tissue, Fibroma         |    X                                                                 X   |             

 _____________________________________________________________________________________________________________________|             

 MUSCULOSKELETAL SYSTEM                    |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Skeletal Muscle                         |                                                                          |             

      Mesothelioma Malignant, Metastatic,  |                                                                          |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  64                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             

                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

    0                                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             

                                           |                                                                          |             

           Peritoneum                      |                                                                          |             

 _____________________________________________________________________________________________________________________|             

 NERVOUS SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 RESPIRATORY SYSTEM                        |                                                                          |             

                                           |__________________________________________________________________________|             

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Alveolar/Bronchiolar Carcinoma       |                      X                                                   |             

      Leukemia Mononuclear                 |                                                                          |             

                                           |__________________________________________________________________________|             

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 SPECIAL SENSES SYSTEM                     |                                                                          |             

                                           |__________________________________________________________________________|             

   Ear                                     |          +                                                               |             

 _____________________________________________________________________________________________________________________|             

 URINARY SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 __________________________________________|__________________________________________________________________________|             

 SYSTEMIC LESIONS                          |                                                                          |             

                                            __________________________________________________________________________|             

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                   X                                                      |             

      Mesothelioma Malignant               |             X                                      X        X            |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  65                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|            |

                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |

    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                              X                           |          1 |

      Mesothelioma Malignant, Metastatic,  |                                                                          |            |

           Peritoneum                      |                                                          X               |          1 |

                                           |__________________________________________________________________________|____________|

   Mesentery                               |                                                          +           +   |   8        |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Acinus, Adenoma                      |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  66                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|            |

                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |

    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |

                                           |                                                                          |            |

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Pheochromocytoma Benign              |                                        X                                 |          2 |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Pars Distalis, Adenoma               |                                              X  X     X              X   |         11 |

      Pars Distalis, Carcinoma             |                   X                                                      |          1 |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      C-Cell, Adenoma                      |                                        X                                 |          3 |

      C-Cell, Carcinoma                    |             X                                                            |          1 |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Peritoneum                              |                                                          +               |   4        |

      Mesothelioma Malignant               |                                                          X               |          4 |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Mesothelioma Malignant, Metastatic,  |                                                                          |            |

           Peritoneum                      |                                                          X               |          1 |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  67                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|            |

                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |

    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 GENITAL SYSTEM - cont                     |                                                                          |            |

                                           |                                                                          |            |

   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Adenoma                              |                                                             X            |          2 |

                                           |__________________________________________________________________________|____________|

   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Mesothelioma Malignant, Metastatic,  |                                                                          |            |

           Peritoneum                      |                                                          X               |          1 |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Bilateral, Interstitial Cell, Adenoma| X  X        X        X     X  X        X        X  X  X        X  X     X|         18 |

      Interstitial Cell, Adenoma           |       X  X     X        X           X     X  X           X  X            |         21 |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              |       +                    +                 +                          +|  13        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                              X                           |          2 |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Thymoma Benign                       |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  +  M  +  +  +  M  M  +  M  +  M  +  +  +  +  M  +  +  M  +  +  +  +|  42        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  68                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|            |

                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |

    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Keratoacanthoma                      |                                                                         X|          2 |

      Squamous Cell Papilloma              |                   X                                                      |          1 |

      Subcutaneous Tissue, Fibroma         |                                                                          |          2 |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Skeletal Muscle                         |                                                          +               |   1        |

      Mesothelioma Malignant, Metastatic,  |                                                                          |            |

           Peritoneum                      |                                                          X               |          1 |

 _____________________________________________________________________________________________________________________|            |

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Alveolar/Bronchiolar Carcinoma       |                                                                          |          1 |

      Leukemia Mononuclear                 |                                              X                           |          1 |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Ear                                     |                                                                          |   1        |

 _____________________________________________________________________________________________________________________|            |

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  69                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|            |

                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| 9| 9| 9|            |

                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     A      |

    0                                      | 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                              X                           |          2 |

      Mesothelioma Malignant               |                                                          X               |          4 |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  70                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 3| 4| 4| 4| 3| 4| 2| 4| 4| 4| 3| 4| 3| 4|             

                             DAY ON TEST   | 8| 9| 1| 9| 0| 9| 0| 5| 3| 1| 9| 0| 2| 7| 1| 2| 4| 0| 8| 1| 6| 7| 0| 4| 1|             

                                           | 8| 7| 5| 7| 3| 7| 2| 7| 3| 4| 7| 7| 2| 7| 4| 7| 6| 4| 3| 9| 3| 3| 8| 2| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 ALIMENTARY SYSTEM                         |                                                                          |             

                                           |__________________________________________________________________________|             

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Jejunum                | A  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Hemangiosarcoma                      | X              X        X              X        X              X     X   |             

      Hemangiosarcoma, Multiple            |    X  X     X     X  X     X     X  X     X  X        X  X  X     X     X|             

      Hepatocellular Adenoma               |                                        X                                 |             

      Hepatocellular Adenoma, Multiple     |                                                                          |             

      Hepatocholangiocarcinoma             |                                                                          |             

      Leukemia Mononuclear                 |                      X  X           X              X  X  X           X   |             

      Lymphoma Malignant                   |                               X                                          |             

                                           |__________________________________________________________________________|             

   Mesentery                               |             +  +              +        +                                 |             

      Chordoma, Metastatic, Mesentery      |                               X                                          |             

      Hemangiosarcoma, Metastatic, Liver   |             X                          X                                 |             

                                           |__________________________________________________________________________|             

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Hemangiosarcoma, Metastatic, Liver   |                                                                          |             

      Acinus, Adenoma                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Lymphoma Malignant                   |                               X                                          |             

                                           |__________________________________________________________________________|             

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  71                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 3| 4| 4| 4| 3| 4| 2| 4| 4| 4| 3| 4| 3| 4|             

                             DAY ON TEST   | 8| 9| 1| 9| 0| 9| 0| 5| 3| 1| 9| 0| 2| 7| 1| 2| 4| 0| 8| 1| 6| 7| 0| 4| 1|             

                                           | 8| 7| 5| 7| 3| 7| 2| 7| 3| 4| 7| 7| 2| 7| 4| 7| 6| 4| 3| 9| 3| 3| 8| 2| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 ALIMENTARY SYSTEM - cont                  |                                                                          |             

                                           |                                                                          |             

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 CARDIOVASCULAR SYSTEM                     |                                                                          |             

                                           |__________________________________________________________________________|             

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Lymphoma Malignant                   |                               X                                          |             

 _____________________________________________________________________________________________________________________|             

 ENDOCRINE SYSTEM                          |                                                                          |             

                                           |__________________________________________________________________________|             

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                         X                          X                     |             

                                           |__________________________________________________________________________|             

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                         X                                                |             

      Pheochromocytoma Benign              |                      X                    X                              |             

                                           |__________________________________________________________________________|             

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Pars Distalis, Adenoma               |                                           X                              |             

                                           |__________________________________________________________________________|             

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      C-Cell, Adenoma                      |       X                          X                                       |             

 _____________________________________________________________________________________________________________________|             

 GENERAL BODY SYSTEM                       |                                                                          |             

                                           |__________________________________________________________________________|             

   Peritoneum                              |                                              +              +            |             

      Mesothelioma Malignant               |                                              X              X            |             

 _____________________________________________________________________________________________________________________|             

 GENITAL SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  72                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 3| 4| 4| 4| 3| 4| 2| 4| 4| 4| 3| 4| 3| 4|             

                             DAY ON TEST   | 8| 9| 1| 9| 0| 9| 0| 5| 3| 1| 9| 0| 2| 7| 1| 2| 4| 0| 8| 1| 6| 7| 0| 4| 1|             

                                           | 8| 7| 5| 7| 3| 7| 2| 7| 3| 4| 7| 7| 2| 7| 4| 7| 6| 4| 3| 9| 3| 3| 8| 2| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 GENITAL SYSTEM - cont                     |                                                                          |             

                                           |                                                                          |             

      Carcinoma                            |                                                                          |             

      Lymphoma Malignant                   |                               X                                          |             

                                           |__________________________________________________________________________|             

   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Interstitial Cell, Adenoma           |       X  X                                            X              X   |             

 _____________________________________________________________________________________________________________________|             

 HEMATOPOIETIC SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                         X                          X                 X   |             

      Lymphoma Malignant                   |                               X                                          |             

                                           |__________________________________________________________________________|             

   Lymph Node                              | +  +  +     +  +  +  +  +  +  +  +  +           +  +  +  +  +  +  +  +   |             

      Leukemia Mononuclear                 |                         X                                                |             

      Inguinal, Leukemia Mononuclear       |                                                    X                     |             

      Mediastinal, Hemangiosarcoma,        |                                                                          |             

          Metastatic, Liver                |                      X              X                                    |             

      Mediastinal, Leukemia Mononuclear    |                         X                             X              X   |             

      Mediastinal, Lymphoma Malignant      |                               X                                          |             

      Pancreatic, Leukemia Mononuclear     |                         X                          X                 X   |             

      Pancreatic, Lymphoma Malignant       |                               X                                          |             

      Renal, Lymphoma Malignant            |                               X                                          |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                         X                          X                     |             

      Lymphoma Malignant                   |                               X                                          |             

                                           |__________________________________________________________________________|             

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                      X  X                          X  X              X   |             

      Lymphoma Malignant                   |                               X                                          |             

                                           |__________________________________________________________________________|             

   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  73                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 3| 4| 4| 4| 3| 4| 2| 4| 4| 4| 3| 4| 3| 4|             

                             DAY ON TEST   | 8| 9| 1| 9| 0| 9| 0| 5| 3| 1| 9| 0| 2| 7| 1| 2| 4| 0| 8| 1| 6| 7| 0| 4| 1|             

                                           | 8| 7| 5| 7| 3| 7| 2| 7| 3| 4| 7| 7| 2| 7| 4| 7| 6| 4| 3| 9| 3| 3| 8| 2| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             

                                           |                                                                          |             

      Hemangiosarcoma, Metastatic, Liver   |                                                                          |             

      Leukemia Mononuclear                 |                      X  X           X              X  X  X           X   |             

      Lymphoma Malignant                   |                               X                                          |             

                                           |__________________________________________________________________________|             

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Lymphoma Malignant                   |                               X                                          |             

 _____________________________________________________________________________________________________________________|             

 INTEGUMENTARY SYSTEM                      |                                                                          |             

                                           |__________________________________________________________________________|             

   Mammary Gland                           | +  +  +  +  +  +  +  +  M  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             

                                           |__________________________________________________________________________|             

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Keratoacanthoma                      |                   X                                                      |             

 _____________________________________________________________________________________________________________________|             

 MUSCULOSKELETAL SYSTEM                    |                                                                          |             

                                           |__________________________________________________________________________|             

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Osteosarcoma                         |                                                                          |             

                                           |__________________________________________________________________________|             

   Skeletal Muscle                         | +     +                       +                                   +      |             

 _____________________________________________________________________________________________________________________|             

 NERVOUS SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                         X                          X                     |             

      Lymphoma Malignant                   |                               X                                          |             

                                           |__________________________________________________________________________|             

   Peripheral Nerve                        |          +                 +  +                                          |             

                                           |__________________________________________________________________________|             

   Spinal Cord                             |          +                 +  +                                          |             

 _____________________________________________________________________________________________________________________|             

 RESPIRATORY SYSTEM                        |                                                                          |             

                                           |__________________________________________________________________________|             

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Alveolar/Bronchiolar Adenoma         |       X                                         X     X                  |             

      Chordoma, Metastatic, Mesentery      |                               X                                          |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  74                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 _____________________________________________________________________________________________________________________              

                                           | 3| 4| 4| 4| 4| 3| 4| 4| 4| 3| 2| 3| 4| 4| 4| 3| 4| 2| 4| 4| 4| 3| 4| 3| 4|             

                             DAY ON TEST   | 8| 9| 1| 9| 0| 9| 0| 5| 3| 1| 9| 0| 2| 7| 1| 2| 4| 0| 8| 1| 6| 7| 0| 4| 1|             

                                           | 8| 7| 5| 7| 3| 7| 2| 7| 3| 4| 7| 7| 2| 7| 4| 7| 6| 4| 3| 9| 3| 3| 8| 2| 8|             

 __________________________________________|__________________________________________________________________________|             

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             

    1.0                                    | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             

    MG/KG/DY                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             

 __________________________________________|__________________________________________________________________________|             

 RESPIRATORY SYSTEM - cont                 |                                                                          |             

                                           |                                                                          |             

      Hemangiosarcoma, Metastatic, Liver   | X  X        X  X     X           X  X     X  X        X        X     X  X|             

      Hepatocholangiocarcinoma, Metastatic,|                                                                          |             

           Liver                           |                                                                          |             

      Leukemia Mononuclear                 |                         X                          X                 X   |             

      Lymphoma Malignant                   |                               X                                          |             

                                           |__________________________________________________________________________|             

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

                                           |__________________________________________________________________________|             

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

 _____________________________________________________________________________________________________________________|             

 SPECIAL SENSES SYSTEM                     |                                                                          |             

                                           |__________________________________________________________________________|             

   Ear                                     | +                                                                        |             

      Neural Crest Tumor                   | X                                                                        |             

 _____________________________________________________________________________________________________________________|             

 URINARY SYSTEM                            |                                                                          |             

                                           |__________________________________________________________________________|             

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                         X                          X                     |             

      Lymphoma Malignant                   |                               X                                          |             

                                           |__________________________________________________________________________|             

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                                                    X                     |             

 __________________________________________|__________________________________________________________________________|             

 SYSTEMIC LESIONS                          |                                                                          |             

                                            __________________________________________________________________________|             

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             

      Leukemia Mononuclear                 |                      X  X           X              X  X  X           X   |             

      Lymphoma Malignant                   |                               X                                          |             

      Mesothelioma Malignant               |                                              X              X            |             

 __________________________________________|__________________________________________________________________________|             

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  75                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3|            |

                             DAY ON TEST   | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7|            |

                                           | 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     A      |

    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM                         |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  I  +  +|  48        |

                                           |__________________________________________________________________________|____________|

   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |

                                           |__________________________________________________________________________|____________|

   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |

                                           |__________________________________________________________________________|____________|

   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Hemangiosarcoma                      |    X           X  X  X  X     X  X     X  X  X  X                       X|         19 |

      Hemangiosarcoma, Multiple            | X     X     X                       X              X  X  X  X  X         |         24 |

      Hepatocellular Adenoma               |    X                                                  X                  |          3 |

      Hepatocellular Adenoma, Multiple     |                                              X                           |          1 |

      Hepatocholangiocarcinoma             |                            X                                             |          1 |

      Leukemia Mononuclear                 |       X                                                                  |          8 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Mesentery                               |    +  +                    +                                +  +         |   9        |

      Chordoma, Metastatic, Mesentery      |                                                                          |          1 |

      Hemangiosarcoma, Metastatic, Liver   |       X                                                     X            |          4 |

                                           |__________________________________________________________________________|____________|

   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Hemangiosarcoma, Metastatic, Liver   |                         X              X                                 |          2 |

      Acinus, Adenoma                      |                                                                   X      |          1 |

                                           |__________________________________________________________________________|____________|

   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  76                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3|            |

                             DAY ON TEST   | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7|            |

                                           | 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     A      |

    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 ALIMENTARY SYSTEM - cont                  |                                                                          |            |

                                           |                                                                          |            |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 CARDIOVASCULAR SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Lymphoma Malignant                   |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 ENDOCRINE SYSTEM                          |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          2 |

                                           |__________________________________________________________________________|____________|

   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          1 |

      Pheochromocytoma Benign              |                                                                          |          2 |

                                           |__________________________________________________________________________|____________|

   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  48        |

                                           |__________________________________________________________________________|____________|

   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Pars Distalis, Adenoma               |                                        X                                 |          2 |

                                           |__________________________________________________________________________|____________|

   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      C-Cell, Adenoma                      |                                                                   X      |          3 |

 _____________________________________________________________________________________________________________________|            |

 GENERAL BODY SYSTEM                       |                                                                          |            |

                                           |__________________________________________________________________________|____________|

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  77                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3|            |

                             DAY ON TEST   | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7|            |

                                           | 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     A      |

    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 GENERAL BODY SYSTEM - cont                |                                                                          |            |

                                           |                                                                          |            |

   Peritoneum                              |                            +                                             |   3        |

      Mesothelioma Malignant               |                            X                                             |          3 |

 _____________________________________________________________________________________________________________________|            |

 GENITAL SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Carcinoma                            |                                                       X                  |          1 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Interstitial Cell, Adenoma           |                                        X     X                    X      |          7 |

 _____________________________________________________________________________________________________________________|            |

 HEMATOPOIETIC SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Leukemia Mononuclear                 |                                                                          |          3 |

      Lymphoma Malignant                   |                                           X                              |          2 |

                                           |__________________________________________________________________________|____________|

   Lymph Node                              | +  +        +  +     +  +  +  +  +  +  +  +  +  +  +     +  +  +  +      |  39        |

      Leukemia Mononuclear                 |                                                                          |          1 |

      Inguinal, Leukemia Mononuclear       |                                                                          |          1 |

      Mediastinal, Hemangiosarcoma,        |                                                                          |            |

          Metastatic, Liver                |                                                          X               |          3 |

      Mediastinal, Leukemia Mononuclear    |                                                                          |          3 |

      Mediastinal, Lymphoma Malignant      |                                           X                              |          2 |

      Pancreatic, Leukemia Mononuclear     |                                                                          |          3 |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  78                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3|            |

                             DAY ON TEST   | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7|            |

                                           | 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     A      |

    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |

                                           |                                                                          |            |

      Pancreatic, Lymphoma Malignant       |                                                                          |          1 |

      Renal, Lymphoma Malignant            |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          2 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X                                                                     |          6 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |

      Hemangiosarcoma, Metastatic, Liver   |                      X                                                   |          1 |

      Leukemia Mononuclear                 |    X  X                                                                  |          9 |

      Lymphoma Malignant                   |                                           X                              |          2 |

                                           |__________________________________________________________________________|____________|

   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |

      Lymphoma Malignant                   |                                           X                              |          2 |

 _____________________________________________________________________________________________________________________|            |

 INTEGUMENTARY SYSTEM                      |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Mammary Gland                           | +  +  M  +  +  +  M  +  +  +  +  +  M  M  +  +  +  M  M  +  +  M  M  +  +|  38        |

                                           |__________________________________________________________________________|____________|

   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Keratoacanthoma                      |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Osteosarcoma                         |                                                                      X   |          1 |

                                           |__________________________________________________________________________|____________|

   Skeletal Muscle                         |                                           +                              |   5        |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  79                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3|            |

                             DAY ON TEST   | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7|            |

                                           | 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     A      |

    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 NERVOUS SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          2 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Peripheral Nerve                        |                                           +              +               |   5        |

                                           |__________________________________________________________________________|____________|

   Spinal Cord                             |                                           +              +               |   5        |

 _____________________________________________________________________________________________________________________|            |

 RESPIRATORY SYSTEM                        |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Alveolar/Bronchiolar Adenoma         |                                                                          |          3 |

      Chordoma, Metastatic, Mesentery      |                                                                          |          1 |

      Hemangiosarcoma, Metastatic, Liver   | X     X     X        X              X  X  X  X  X  X  X  X  X            |         26 |

      Hepatocholangiocarcinoma, Metastatic,|                                                                          |            |

           Liver                           |                            X                                             |          1 |

      Leukemia Mononuclear                 |                                                                          |          3 |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

                                           |__________________________________________________________________________|____________|

   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

 _____________________________________________________________________________________________________________________|            |

 SPECIAL SENSES SYSTEM                     |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Ear                                     |                                                                          |   1        |

      Neural Crest Tumor                   |                                                                          |          1 |

 _____________________________________________________________________________________________________________________|            |

 URINARY SYSTEM                            |                                                                          |            |

                                           |__________________________________________________________________________|____________|

   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          2 |

 _____________________________________________________________________________________________________________________|____________|

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                             Page  80                                                               

                                                                                                                                   

NTP Experiment-Test: 05161-05                        NEOPLASMS BY INDIVIDUAL ANIMAL                               Report: PEIRPT04  

Study Type: CHRONIC                                            RIDDELLIINE                                        Date: 12/15/00    

Route: GAVAGE                                                                                                     Time: 12:06:03    

                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 

                                           | 4| 4| 4| 2| 4| 3| 3| 4| 4| 4| 3| 3| 4| 4| 4| 4| 4| 4| 3| 3| 4| 4| 4| 4| 3|            |

                             DAY ON TEST   | 1| 4| 1| 6| 3| 2| 1| 0| 4| 0| 7| 9| 1| 6| 4| 0| 0| 2| 9| 6| 1| 1| 9| 0| 7|            |

                                           | 0| 9| 4| 6| 7| 1| 8| 0| 0| 0| 3| 7| 2| 2| 0| 7| 2| 4| 8| 4| 5| 1| 7| 7| 5|            |

 __________________________________________|__________________________________________________________________________|     T (*)  |

                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     O      |

   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|     T      |

                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|     A      |

    1.0                                    | 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0|     L      |

    MG/KG/DY                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|            |

 _____________________________________________________________________________________________________________________|____________|

 URINARY SYSTEM - cont                     |                                                                          |            |

                                           |                                                                          |            |

      Lymphoma Malignant                   |                                                                          |          1 |

                                           |__________________________________________________________________________|____________|

   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |                                                                          |          1 |

 __________________________________________________________________________________________________________________________________ 

 SYSTEMIC LESIONS                          |                                                                          |            |

                                            __________________________________________________________________________|____________|

   Multiple Organs                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |

      Leukemia Mononuclear                 |    X  X                                                                  |          9 |

      Lymphoma Malignant                   |                                           X                              |          2 |

      Mesothelioma Malignant               |                            X                                             |          3 |

 __________________________________________________________________________________________________________________________________ 

                                                                                                                                    

                         * : Total animals with tissue examined microscopically; total animals with tumor                           

                         + : Tissue examined microscopically                      M : Missing tissue                                

                         X : Lesion present                                       A : Autolysis precludes evaluation                

                         I : Insufficient tissue                              BLANK : Not examined microscopically                  

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                                                                                                    

                                                             Page  81                                                               

                                                                                                                                   

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                                  ----------              END OF REPORT             ----------                                      

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