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https://ntp.niehs.nih.gov/go/1561

TDMS Study 05163-01 Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                         C. I. ACID RED 114


NTP Experiment-Test: 05163-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: DOSED WATER                                                                                                Time: 21:51:40




       Facility:  Hazleton Laboratories America, Inc.

       Chemical CAS #:  6459-94-5

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           45           75           70                                     
  Scheduled Sacrifice                                 20           10           10           20                                     
  Early Deaths                                                                                                                      
    Dead                                               4            6           17           13                                     
    Moribund                                          10           16           41           37                                     
    Accident                                                                     1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                36           13            6                                                  
  Animals Examined Microscopically                    50           35           65           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (35)         (63)         (49)                                   
      Edema                                                         1 (3%)                                                          
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Acute                                           1 (3%)                                                          
      Ulcer                                                                      2 (3%)       1 (2%)                                
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
   Intestine Large, Colon                             (50)         (35)         (63)         (48)                                   
      Hemorrhage                                                                              1 (2%)                                
      Parasite Metazoan                                                          3 (5%)       1 (2%)                                
   Intestine Large, Rectum                            (50)         (35)         (64)         (49)                                   
      Diverticulum                                                                            1 (2%)                                
      Parasite Metazoan                                1 (2%)       3 (9%)       5 (8%)                                             
   Intestine Small, Ileum                             (50)         (35)         (63)         (50)                                   
      Parasite Metazoan                                1 (2%)                    1 (2%)       1 (2%)                                
   Liver                                              (50)         (35)         (64)         (50)                                   
      Angiectasis                                      1 (2%)       3 (9%)       6 (9%)       3 (6%)                                
      Basophilic Focus                                38 (76%)     20 (57%)     38 (59%)     17 (34%)                               
      Clear Cell Focus                                 1 (2%)                                 1 (2%)                                
      Congestion                                                                 1 (2%)                                             
      Cyst                                                                       3 (5%)                                             
      Degeneration, Cystic                                          5 (14%)     25 (39%)     14 (28%)                               
      Eosinophilic Focus                                           12 (34%)     38 (59%)     42 (84%)                               
      Fatty Change, Diffuse                                                      2 (3%)                                             
      Fatty Change, Focal                              1 (2%)                                 4 (8%)                                
      Fatty Change, Multifocal                                      1 (3%)       6 (9%)       3 (6%)                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Hematocyst                                                    1 (3%)                    1 (2%)                                
      Hematopoietic Cell Proliferation                              7 (20%)     15 (23%)      9 (18%)                               
      Hemorrhage                                                                 1 (2%)                                             
      Hepatodiaphragmatic Nodule                       9 (18%)      3 (9%)       5 (8%)       9 (18%)                               
      Hyperplasia, Focal                                                         1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infiltration Cellular, Polymorphonuclear                                   1 (2%)                                             
      Inflammation, Granulomatous, Multifocal         22 (44%)      6 (17%)      2 (3%)       1 (2%)                                
      Mixed Cell Focus                                 2 (4%)       9 (26%)      8 (13%)     15 (30%)                               
      Necrosis, Coagulative, Multifocal                1 (2%)       1 (3%)       2 (3%)       4 (8%)                                
      Necrosis, Focal                                                            1 (2%)                                             
      Regeneration                                                  2 (6%)       3 (5%)       1 (2%)                                
      Bile Duct, Cyst                                                                         1 (2%)                                
      Bile Duct, Hyperplasia                          10 (20%)      7 (20%)      4 (6%)                                             
      Centrilobular, Fatty Change                                   3 (9%)       1 (2%)       1 (2%)                                
      Centrilobular, Necrosis, Coagulative             1 (2%)       2 (6%)       6 (9%)       4 (8%)                                
      Periportal, Fatty Change                         1 (2%)                    1 (2%)                                             
   Mesentery                                          (4)          (1)          (4)          (11)                                   
      Inflammation, Chronic                                         1 (100%)                                                        
      Fat, Necrosis, Focal                             4 (100%)                  2 (50%)                                            
   Pancreas                                           (50)         (35)         (62)         (50)                                   
      Necrosis, Focal                                                                         1 (2%)                                
      Acinus, Atrophy                                 10 (20%)      4 (11%)      6 (10%)      1 (2%)                                
      Acinus, Hyperplasia, Focal                                                 2 (3%)                                             
   Salivary Glands                                    (48)         (35)         (64)         (50)                                   
      Acinus, Atrophy                                               1 (3%)                    1 (2%)                                
      Adventitia, Inflammation, Chronic                                          1 (2%)                                             
   Stomach, Forestomach                               (50)         (35)         (64)         (50)                                   
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                      1 (2%)                    1 (2%)       2 (4%)                                
      Inflammation, Acute                                           2 (6%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Ulcer                                                         1 (3%)       3 (5%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (35)         (64)         (50)                                   
      Degeneration, Cystic                                                                    1 (2%)                                
      Edema                                                                                   1 (2%)                                
      Erosion                                                                    3 (5%)       4 (8%)                                
      Mineralization                                   1 (2%)                    1 (2%)       4 (8%)                                
   Tooth                                                           (1)          (1)          (2)                                    
      Peridontal Tissue, Hyperplasia                                1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (35)         (64)         (49)                                   
      Cardiomyopathy                                   8 (16%)      5 (14%)      8 (13%)      2 (4%)                                
      Mineralization                                   1 (2%)                    1 (2%)       2 (4%)                                
      Atrium, Dilatation                                            1 (3%)                                                          
      Atrium, Thrombosis                               1 (2%)       2 (6%)       6 (9%)       1 (2%)                                
      Valve, Inflammation, Chronic Active                           1 (3%)                                                          
      Valve, Thrombosis                                             1 (3%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (35)         (64)         (50)                                   
      Angiectasis                                      4 (8%)       5 (14%)      5 (8%)       8 (16%)                               
      Atrophy                                                       1 (3%)                                                          
      Fibrosis                                                                   1 (2%)                                             
      Hematopoietic Cell Proliferation                                           1 (2%)       2 (4%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Focal                                                         1 (2%)                                             
      Necrosis, Focal                                               1 (3%)                    1 (2%)                                
      Necrosis, Multifocal                             1 (2%)       1 (3%)                    1 (2%)                                
      Vacuolization Cytoplasmic, Diffuse               1 (2%)       1 (3%)       2 (3%)                                             
      Vacuolization Cytoplasmic, Focal                 3 (6%)       4 (11%)     10 (16%)      6 (12%)                               
      Vacuolization Cytoplasmic, Multifocal            1 (2%)       2 (6%)       3 (5%)                                             
      Bilateral, Necrosis, Focal                                                              1 (2%)                                
      Bilateral, Vacuolization Cytoplasmic, Focal                                2 (3%)                                             
      Bilateral, Vacuolization Cytoplasmic,                                                                                         
          Multifocal                                                                          1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (35)         (64)         (50)                                   
      Hyperplasia, Focal                               5 (10%)      5 (14%)     11 (17%)      2 (4%)                                
      Hyperplasia, Multifocal                          1 (2%)       2 (6%)       4 (6%)                                             
   Parathyroid Gland                                  (48)         (34)         (62)         (47)                                   
      Hyperplasia                                                                             5 (11%)                               
   Pituitary Gland                                    (50)         (35)         (64)         (49)                                   
      Angiectasis                                      6 (12%)      2 (6%)       5 (8%)                                             
      Congestion                                                                 1 (2%)                                             
      Cyst                                            10 (20%)      8 (23%)     22 (34%)      7 (14%)                               
      Hemorrhage                                       2 (4%)                                                                       
      Pigmentation, Hemosiderin                                                               1 (2%)                                
      Pars Distalis, Cyst                                                                     1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                             3 (9%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (35)         (64)         (50)                                   
      Ultimobranchial Cyst                                                       1 (2%)       2 (4%)                                
      C-Cell, Hyperplasia, Focal                       4 (8%)       3 (9%)       3 (5%)       1 (2%)                                
      Follicle, Cyst                                                1 (3%)       2 (3%)                                             
      Follicular Cell, Hyperplasia, Focal              1 (2%)       1 (3%)       3 (5%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                   (1)          (2)                                    
      Mineralization                                                                          1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (32)         (62)         (50)                                   
      Hyperplasia, Focal, Glandular                    4 (8%)       2 (6%)       8 (13%)      2 (4%)                                
      Hyperplasia, Focal, Squamous                     1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
      Inflammation, Suppurative                                                  1 (2%)       1 (2%)                                
      Duct, Ectasia                                    1 (2%)       3 (9%)       3 (5%)       8 (16%)                               
   Ovary                                              (50)         (35)         (64)         (49)                                   
      Bilateral, Periovarian Tissue, Cyst                                                     1 (2%)                                
      Interstitium, Cyst                                            1 (3%)                                                          
      Periovarian Tissue, Cyst                         2 (4%)                    1 (2%)       3 (6%)                                
   Uterus                                             (50)         (35)         (64)         (49)                                   
      Decidual Reaction                                                          1 (2%)                                             
      Hemorrhage                                                    1 (3%)                                                          
      Hydrometra                                       2 (4%)       1 (3%)       2 (3%)       2 (4%)                                
      Cervix, Cyst                                     2 (4%)       1 (3%)                                                          
      Cervix, Inflammation, Suppurative                1 (2%)                                                                       
      Endometrium, Cyst                                1 (2%)       2 (6%)       5 (8%)                                             
      Endometrium, Hyperplasia                                      1 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (35)         (63)         (50)                                   
      Atrophy                                                                                 4 (8%)                                
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Hyperplasia, Multifocal, Re Cell                 1 (2%)                                                                       
      Myelofibrosis                                                 2 (6%)                    1 (2%)                                
   Lymph Node                                         (50)         (35)         (64)         (49)                                   
      Iliac, Hyperplasia, Plasma Cell                  1 (2%)                                                                       
      Iliac, Sinus, Ectasia                                                                   1 (2%)                                
      Inguinal, Hyperplasia, Plasma Cell               1 (2%)                                                                       
      Mediastinal, Hemorrhage                         10 (20%)      7 (20%)      7 (11%)      8 (16%)                               
      Mediastinal, Hyperplasia, Plasma Cell                         1 (3%)                    1 (2%)                                
      Mediastinal, Hyperplasia, Re Cell                                          1 (2%)                                             
      Pancreatic, Hemorrhage                                                     1 (2%)                                             
   Lymph Node, Mandibular                             (46)         (35)         (64)         (48)                                   
      Congestion                                       1 (2%)                                 1 (2%)                                
      Hemorrhage                                       2 (4%)       2 (6%)       2 (3%)       5 (10%)                               
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Hyperplasia, Plasma Cell                         9 (20%)      9 (26%)     23 (36%)     15 (31%)                               
      Hyperplasia, Re Cell                                                       2 (3%)                                             
      Adventitia, Inflammation, Chronic                                          1 (2%)                                             
      Sinus, Ectasia                                   6 (13%)      6 (17%)      3 (5%)       2 (4%)                                
   Lymph Node, Mesenteric                             (50)         (35)         (64)         (48)                                   
      Hemorrhage                                       1 (2%)       1 (3%)       4 (6%)       4 (8%)                                
      Hyperplasia, Re Cell                                                       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Infiltration Cellular, Mast Cell                                                        1 (2%)                                
   Spleen                                             (50)         (35)         (63)         (50)                                   
      Depletion Lymphoid                                                                      5 (10%)                               
      Fibrosis                                                      1 (3%)       2 (3%)                                             
      Hematopoietic Cell Proliferation                 3 (6%)       8 (23%)     20 (32%)     16 (32%)                               
      Hyperplasia, Focal, Re Cell                                   1 (3%)                                                          
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Necrosis                                                                   1 (2%)                                             
      Pigmentation, Hemosiderin                                     1 (3%)       4 (6%)       4 (8%)                                
      Capsule, Hemorrhage                                                        1 (2%)                                             
      Red Pulp, Atrophy                                                          2 (3%)       1 (2%)                                
   Thymus                                             (40)         (30)         (59)         (42)                                   
      Ectopic Parathyroid Gland                                                               1 (2%)                                
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Epithelial Cell, Hyperplasia                    25 (63%)     20 (67%)     29 (49%)     17 (40%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)         (35)         (58)         (45)                                   
      Galactocele                                                   1 (3%)       2 (3%)                                             
      Hyperplasia, Nodular                                                       1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Duct, Ectasia                                    6 (12%)      4 (11%)      3 (5%)                                             
   Skin                                               (50)         (35)         (65)         (49)                                   
      Acanthosis, Focal                                                                       1 (2%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Ulcer, Multifocal                                                          1 (2%)                                             
      Hair Follicle, Hyperplasia, Basal Cell, Focal                 1 (3%)                                                          
      Subcutaneous Tissue, Inflammation, Acute         1 (2%)                                                                       
      Subcutaneous Tissue, Inflammation, Chronic                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (3)          (7)                       (10)                                   
      Cartilage, Sternum, Degeneration                                                        1 (10%)                               
      Cranium, Fibrous Osteodystrophy                               1 (14%)                   8 (80%)                               
      Sternum, Fibrous Osteodystrophy                               1 (14%)                   2 (20%)                               
      Sternum, Osteopetrosis                           3 (100%)     5 (71%)                   1 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (49)         (35)         (64)         (50)                                   
      Hemorrhage                                       1 (2%)       3 (9%)       6 (9%)       2 (4%)                                
      Necrosis, Focal                                                            1 (2%)                                             
      Brain Stem, Compression                         12 (24%)      9 (26%)                   1 (2%)                                
      Meninges, Inflammation, Subacute                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (35)         (65)         (50)                                   
      Congestion                                       1 (2%)       2 (6%)       2 (3%)       2 (4%)                                
      Edema                                                         1 (3%)       1 (2%)                                             
      Hemorrhage                                                    2 (6%)       4 (6%)       1 (2%)                                
      Infiltration Cellular, Histiocyte               13 (26%)     22 (63%)     32 (49%)     27 (54%)                               
      Mineralization                                                                          1 (2%)                                
      Alveolar Epithelium, Hyperplasia, Focal          6 (12%)      5 (14%)     13 (20%)     12 (24%)                               
      Alveolar Epithelium, Hyperplasia, Multifocal                  1 (3%)       2 (3%)       8 (16%)                               
      Bronchiole, Foreign Body                                                   1 (2%)                                             
      Bronchiole, Inflammation, Acute                  1 (2%)                    2 (3%)                                             
      Interstitium, Inflammation                       1 (2%)       1 (3%)       1 (2%)                                             
      Peribronchiolar, Inflammation, Chronic                                     1 (2%)                                             
      Peribronchiolar, Alveolus, Inflammation,                                                                                      
           Acute                                       1 (2%)                    2 (3%)                                             
   Nose                                               (50)         (35)         (63)         (49)                                   
      Fungus                                           2 (4%)                    1 (2%)                                             
      Hemorrhage                                                    1 (3%)       1 (2%)       2 (4%)                                
      Inflammation, Suppurative                        4 (8%)       2 (6%)       9 (14%)      3 (6%)                                
   Trachea                                            (50)         (35)         (64)         (50)                                   
      Ectopic Tissue                                                             1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Adventitia, Inflammation, Chronic                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (2)          (5)          (3)                                    
      Cataract                                         3 (100%)     2 (100%)     3 (60%)                                            
      Inflammation, Chronic                                                      1 (20%)                                            
      Necrosis                                                                                1 (33%)                               
      Anterior Chamber, Inflammation, Suppurative                                1 (20%)      1 (33%)                               
      Retina, Degeneration                             2 (67%)                   3 (60%)                                            
   Zymbal's Gland                                     (50)         (35)         (63)         (49)                                   
      Abscess                                                                                 1 (2%)                                
      Ectasia                                          1 (2%)                                 2 (4%)                                
      Hyperplasia, Focal, Glandular                    1 (2%)                    2 (3%)                                             
      Hyperplasia, Focal, Squamous                                               3 (5%)       3 (6%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      0.015        0.03         0.06                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Hyperplasia, Multifocal, Squamous                                                       1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (35)         (64)         (50)                                   
      Cyst                                                                       2 (3%)                                             
      Fatty Change                                                  1 (3%)                                                          
      Fibrosis, Focal                                               1 (3%)                                                          
      Hydronephrosis                                                                          2 (4%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Karyomegaly                                                                            11 (22%)                               
      Nephropathy                                     48 (96%)     32 (91%)     60 (94%)     48 (96%)                               
      Pigmentation                                                  1 (3%)       1 (2%)                                             
      Interstitial Tissue, Fibrosis, Focal                          1 (3%)                                                          
      Interstitial Tissue, Inflammation                             1 (3%)       1 (2%)                                             
      Renal Tubule, Hyperplasia, Focal                                                        1 (2%)                                
   Urinary Bladder                                    (49)         (35)         (64)         (49)                                   
      Ectasia                                                                    2 (3%)                                             
      Hemorrhage                                                                 2 (3%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           45           75           70                                     
  Scheduled Sacrifice                                 19           10           10           20                                     
  Early Deaths                                                                                                                      
    Dead                                              13           11           16           16                                     
    Moribund                                          13            9           23           33                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           15           26            1                                     
    Dead                                               1                                                                            
  Surplus                                              1                                                                            
  Animals Examined Microscopically                    50           35           65           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (35)         (64)         (49)                                   
      Edema                                                                                   2 (4%)                                
      Hemorrhage                                                    1 (3%)                                                          
   Intestine Large, Colon                             (50)         (35)         (64)         (50)                                   
      Diverticulum                                     1 (2%)                                                                       
      Erosion                                                                    1 (2%)                                             
      Parasite Metazoan                                3 (6%)       1 (3%)       6 (9%)       3 (6%)                                
   Intestine Large, Rectum                            (50)         (34)         (64)         (50)                                   
      Inflammation, Chronic Active                                  1 (3%)                                                          
      Inflammation, Suppurative                                     1 (3%)                                                          
      Parasite Metazoan                                3 (6%)       3 (9%)       4 (6%)       3 (6%)                                
      Ulcer                                            1 (2%)                                                                       
   Intestine Small, Ileum                             (50)         (35)         (64)         (49)                                   
      Inflammation, Granulomatous                      1 (2%)                                                                       
      Ulcer                                                         1 (3%)                                                          
   Liver                                              (50)         (35)         (65)         (50)                                   
      Angiectasis                                      3 (6%)       2 (6%)       2 (3%)                                             
      Basophilic Focus                                16 (32%)     15 (43%)     23 (35%)     25 (50%)                               
      Clear Cell Focus                                 2 (4%)                    2 (3%)       2 (4%)                                
      Cyst                                                                                    1 (2%)                                
      Cytoplasmic Alteration, Focal                                 1 (3%)                                                          
      Degeneration, Cystic                             6 (12%)     13 (37%)     33 (51%)     31 (62%)                               
      Eosinophilic Focus                               6 (12%)      5 (14%)     19 (29%)     26 (52%)                               
      Fatty Change, Diffuse                            1 (2%)                                                                       
      Fatty Change, Focal                              1 (2%)                    2 (3%)                                             
      Fatty Change, Multifocal                                                   2 (3%)       5 (10%)                               
      Hematocyst                                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                 1 (2%)       2 (6%)       6 (9%)      14 (28%)                               
      Hepatodiaphragmatic Nodule                       3 (6%)       1 (3%)       8 (12%)      4 (8%)                                
      Hepatodiaphragmatic Nodule, Multiple             1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Infarct                                          1 (2%)       1 (3%)       4 (6%)       5 (10%)                               
      Inflammation, Granulomatous, Multifocal          1 (2%)                    1 (2%)       1 (2%)                                
      Mixed Cell Focus                                 7 (14%)      9 (26%)     24 (37%)     14 (28%)                               
      Necrosis, Coagulative, Focal                                               1 (2%)                                             
      Necrosis, Coagulative, Multifocal                                          1 (2%)       3 (6%)                                
      Regeneration                                     2 (4%)       1 (3%)       3 (5%)       1 (2%)                                
      Bile Duct, Cyst                                  1 (2%)                    1 (2%)                                             
      Bile Duct, Hyperplasia                          33 (66%)     23 (66%)     31 (48%)     10 (20%)                               
      Centrilobular, Fatty Change                                   3 (9%)       2 (3%)       2 (4%)                                
      Centrilobular, Hemorrhage                        1 (2%)                                                                       
      Centrilobular, Necrosis, Coagulative             3 (6%)       3 (9%)       8 (12%)     18 (36%)                               
      Centrilobular, Necrosis, Coagulative, Focal                                             1 (2%)                                
      Periportal, Fatty Change                         1 (2%)                                                                       
      Portal Vein, Thrombosis                                                    1 (2%)                                             
      Serosa, Fibrosis, Focal                          2 (4%)                                                                       
      Serosa, Pigmentation, Focal                      2 (4%)                                                                       
   Mesentery                                          (11)         (6)          (1)          (6)                                    
      Hemorrhage                                       1 (9%)                                                                       
      Artery, Inflammation, Chronic Active             1 (9%)                                                                       
      Fat, Necrosis, Focal                             8 (73%)      3 (50%)      1 (100%)     5 (83%)                               
   Pancreas                                           (50)         (35)         (64)         (49)                                   
      Metaplasia                                                                              1 (2%)                                
      Acinus, Atrophy                                 13 (26%)      7 (20%)     18 (28%)      7 (14%)                               
      Acinus, Hyperplasia, Focal                       1 (2%)       1 (3%)                    2 (4%)                                
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
   Salivary Glands                                    (49)         (35)         (64)         (50)                                   
      Edema                                                                                   1 (2%)                                
   Stomach, Forestomach                               (50)         (35)         (65)         (50)                                   
      Erosion                                                                    1 (2%)                                             
      Hyperplasia                                      2 (4%)                                                                       
      Inflammation, Acute                                                        2 (3%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Ulcer                                            4 (8%)       1 (3%)       2 (3%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (35)         (65)         (50)                                   
      Degeneration, Cystic                                                                    1 (2%)                                
      Erosion                                          1 (2%)                    3 (5%)       6 (12%)                               
      Inflammation, Chronic                            1 (2%)       1 (3%)                                                          
      Inflammation, Focal, Suppurative                                           1 (2%)                                             
      Ulcer                                                                      2 (3%)                                             
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
   Tooth                                              (1)                                                                           
      Dysplasia                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (35)         (65)         (50)                                   
      Cardiomyopathy                                  24 (48%)     17 (49%)     36 (55%)     24 (48%)                               
      Inflammation, Suppurative                                                               1 (2%)                                
      Atrium, Dilatation                               1 (2%)       2 (6%)       1 (2%)       1 (2%)                                
      Atrium, Thrombosis                               5 (10%)      4 (11%)     18 (28%)     18 (36%)                               
      Ventricle Right, Thrombosis                                                             1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (35)         (63)         (50)                                   
      Bilateral, Hyperplasia, Focal                                                           2 (4%)                                
   Adrenal Gland, Cortex                              (50)         (35)         (63)         (50)                                   
      Angiectasis                                      1 (2%)                    2 (3%)                                             
      Atrophy                                                                    1 (2%)                                             
      Necrosis, Diffuse                                                          1 (2%)                                             
      Vacuolization Cytoplasmic, Diffuse               1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                 2 (4%)       1 (3%)       8 (13%)      3 (6%)                                
      Vacuolization Cytoplasmic, Multifocal            1 (2%)       2 (6%)                    2 (4%)                                
   Adrenal Gland, Medulla                             (50)         (35)         (63)         (49)                                   
      Hyperplasia, Focal                              11 (22%)      5 (14%)     20 (32%)     11 (22%)                               
      Hyperplasia, Multifocal                          1 (2%)       1 (3%)       6 (10%)      2 (4%)                                
      Necrosis, Diffuse                                                          1 (2%)                                             
      Bilateral, Hyperplasia, Focal                                 1 (3%)       1 (2%)                                             
      Bilateral, Hyperplasia, Multifocal                                         1 (2%)                                             
   Pituitary Gland                                    (50)         (35)         (65)         (47)                                   
      Angiectasis                                      2 (4%)       2 (6%)       3 (5%)       1 (2%)                                
      Cyst                                             5 (10%)      3 (9%)       3 (5%)       1 (2%)                                
      Ectopic Tissue                                                                          1 (2%)                                
      Hemorrhage                                                                 1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Pars Distalis, Hyperplasia, Focal                1 (2%)       1 (3%)       2 (3%)       3 (6%)                                
   Thyroid Gland                                      (50)         (35)         (65)         (49)                                   
      Ultimobranchial Cyst                                          1 (3%)       2 (3%)                                             
      C-Cell, Hyperplasia, Focal                       1 (2%)       1 (3%)       4 (6%)                                             
      Follicle, Cyst                                                             1 (2%)       1 (2%)                                
      Follicular Cell, Hyperplasia, Focal                           1 (3%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (3)          (3)                                    
      Inflammation, Chronic                            1 (100%)                  1 (33%)                                            
      Thrombosis, Chronic                              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (35)         (64)         (50)                                   
      Granuloma Sperm                                  1 (2%)                                                                       
      Inflammation, Chronic Active                                               1 (2%)                                             
   Preputial Gland                                    (44)         (34)         (60)         (48)                                   
      Hyperplasia, Focal, Glandular                                              1 (2%)       1 (2%)                                
      Hyperplasia, Focal, Squamous                                  1 (3%)                                                          
      Inflammation, Chronic Active                     1 (2%)                    3 (5%)       5 (10%)                               
      Inflammation, Suppurative                        1 (2%)       1 (3%)       3 (5%)       1 (2%)                                
      Duct, Ectasia                                    3 (7%)                    2 (3%)       4 (8%)                                
   Prostate                                           (50)         (34)         (64)         (50)                                   
      Atrophy                                          2 (4%)       4 (12%)      3 (5%)                                             
      Hyperplasia, Focal                               2 (4%)       6 (18%)     10 (16%)      2 (4%)                                
      Hyperplasia, Multifocal                          3 (6%)       1 (3%)       3 (5%)                                             
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)       1 (3%)       3 (5%)       8 (16%)                               
      Inflammation, Suppurative                        2 (4%)       3 (9%)                    1 (2%)                                
   Seminal Vesicle                                    (49)         (34)         (65)         (48)                                   
      Atrophy                                         30 (61%)     24 (71%)     51 (78%)     18 (38%)                               
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
      Inflammation, Suppurative                                     1 (3%)                                                          
   Testes                                             (50)         (35)         (64)         (50)                                   
      Giant Cell                                       1 (2%)                    1 (2%)                                             
      Granuloma Sperm                                                            1 (2%)                                             
      Hypospermia                                      5 (10%)      8 (23%)      6 (9%)       3 (6%)                                
      Mineralization                                                             1 (2%)                                             
      Artery, Inflammation, Chronic Active             1 (2%)                                                                       
      Bilateral, Hypospermia                           2 (4%)                                                                       
      Interstitial Cell, Hyperplasia                   6 (12%)      3 (9%)       3 (5%)       8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (35)         (64)         (50)                                   
      Atrophy                                          4 (8%)       1 (3%)                    1 (2%)                                
      Hemorrhage                                       2 (4%)                                                                       
      Myelofibrosis                                                 1 (3%)       1 (2%)       1 (2%)                                
   Lymph Node                                         (49)         (35)         (65)         (50)                                   
      Mediastinal, Hemorrhage                          7 (14%)      8 (23%)      5 (8%)      11 (22%)                               
      Mediastinal, Pigmentation, Hemosiderin           1 (2%)       1 (3%)                    1 (2%)                                
      Mediastinal, Sinus, Ectasia                                                1 (2%)                                             
      Pancreatic, Hemorrhage                           1 (2%)                                 1 (2%)                                
   Lymph Node, Mandibular                             (49)         (35)         (65)         (49)                                   
      Fibrosis                                                                                1 (2%)                                
      Hemorrhage                                       4 (8%)       1 (3%)       2 (3%)       2 (4%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Hyperplasia, Plasma Cell                         8 (16%)      8 (23%)      2 (3%)       9 (18%)                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Sinus, Ectasia                                   5 (10%)      7 (20%)     13 (20%)      6 (12%)                               
   Lymph Node, Mesenteric                             (49)         (35)         (64)         (50)                                   
      Fibrosis                                                                                1 (2%)                                
      Hemorrhage                                       1 (2%)                                 2 (4%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Hyperplasia, Re Cell                                                                    1 (2%)                                
      Sinus, Ectasia                                   1 (2%)       1 (3%)                                                          
   Spleen                                             (50)         (35)         (64)         (50)                                   
      Ectopic Tissue                                                             1 (2%)                                             
      Edema                                                         1 (3%)                                                          
      Fibrosis                                         1 (2%)       3 (9%)       2 (3%)       3 (6%)                                
      Hematopoietic Cell Proliferation                 3 (6%)       4 (11%)      3 (5%)      21 (42%)                               
      Hemorrhage                                                                              1 (2%)                                
      Necrosis                                         1 (2%)       1 (3%)       1 (2%)       1 (2%)                                
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Red Pulp, Atrophy                                                          2 (3%)                                             
   Thymus                                             (41)         (22)         (47)         (40)                                   
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                       3 (7%)       2 (9%)                    2 (5%)                                
      Epithelial Cell, Hyperplasia                    20 (49%)      8 (36%)     19 (40%)     14 (35%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (46)         (31)         (61)         (37)                                   
      Galactocele                                                   1 (3%)                    1 (3%)                                
      Hyperplasia, Nodular                             1 (2%)                    1 (2%)                                             
   Skin                                               (50)         (35)         (65)         (50)                                   
      Cyst Epithelial Inclusion                        1 (2%)       1 (3%)                    1 (2%)                                
      Hyperkeratosis, Focal                                                      1 (2%)       1 (2%)                                
      Ulcer                                            1 (2%)       1 (3%)                                                          
      Epidermis, Hyperplasia, Basal Cell, Focal                     1 (3%)                                                          
      Hair Follicle, Hyperplasia, Basal Cell, Focal                                           1 (2%)                                
      Sebaceous Gland, Hyperplasia, Focal                                        3 (5%)       1 (2%)                                
      Subcutaneous Tissue, Edema                                                 1 (2%)       2 (4%)                                
      Subcutaneous Tissue, Inflammation, Acute                                   2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                                                                      (2)                                    
      Sternum, Osteopetrosis                                                                  1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (35)         (64)         (50)                                   
      Hemorrhage                                       5 (10%)      2 (6%)       7 (11%)      2 (4%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Brain Stem, Compression                          3 (6%)       2 (6%)       3 (5%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (35)         (65)         (50)                                   
      Congestion                                       3 (6%)                    1 (2%)       2 (4%)                                
      Granuloma, Multifocal                                         1 (3%)                                                          
      Hemorrhage                                       1 (2%)                    1 (2%)       3 (6%)                                
      Infiltration Cellular, Histiocyte                9 (18%)     11 (31%)     18 (28%)      9 (18%)                               
      Pigmentation, Focal                                                                     1 (2%)                                
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)       4 (11%)      5 (8%)       6 (12%)                               
      Alveolar Epithelium, Hyperplasia, Multifocal                               4 (6%)       2 (4%)                                
      Bronchiole, Inflammation, Acute                  1 (2%)                                 2 (4%)                                
      Capillary, Thrombosis                                                      1 (2%)       2 (4%)                                
      Interstitium, Inflammation                       4 (8%)       1 (3%)       4 (6%)       7 (14%)                               
   Nose                                               (50)         (35)         (65)         (50)                                   
      Foreign Body                                                                            1 (2%)                                
      Fungus                                           2 (4%)       7 (20%)      8 (12%)      5 (10%)                               
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Focal                                                         1 (2%)       1 (2%)                                
      Hyperplasia, Multifocal                                                    1 (2%)                                             
      Inflammation, Suppurative                       10 (20%)     11 (31%)     15 (23%)     14 (28%)                               
      Ulcer                                                                                   1 (2%)                                
   Trachea                                            (50)         (35)         (65)         (50)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (2)          (1)                                    
      Cataract                                                                   2 (100%)     1 (100%)                              
      Necrosis                                                      1 (100%)                                                        
      Retina, Degeneration                                                       2 (100%)                                           
   Zymbal's Gland                                     (50)         (35)         (64)         (50)                                   
      Ectasia                                                                                 2 (4%)                                
      Hyperplasia, Focal, Squamous                                                            1 (2%)                                
      Inflammation, Suppurative                                                  2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05163-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                         C. I. ACID RED 114                                    Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 21:51:40  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      0.007        0.015        0.03                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (35)         (65)         (50)                                   
      Cyst                                                          1 (3%)       1 (2%)       1 (2%)                                
      Hydronephrosis                                   1 (2%)                                                                       
      Infarct                                                                    1 (2%)       1 (2%)                                
      Inflammation, Suppurative                                                               1 (2%)                                
      Nephropathy                                     47 (94%)     34 (97%)     65 (100%)    46 (92%)                               
      Pigmentation                                     3 (6%)       2 (6%)       2 (3%)                                             
      Interstitial Tissue, Fibrosis, Focal                          1 (3%)                                                          
   Urinary Bladder                                    (50)         (34)         (64)         (50)                                   
      Ectasia                                          1 (2%)                    1 (2%)       1 (2%)                                
      Hemorrhage                                       1 (2%)                    2 (3%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------