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TDMS Study 05181-03 Pathology Tables

NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11     
LAB: Battelle Northwest                                     TETRAHYDROFURAN                                    DATE: 02/20/96       
EXPERIMENT: 05181 TEST: 03                                                                                     TIME: 16:36:08       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-95259                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 60560C       
PATHOLOGIST: R. RENNE                                                                                          CAS: 0109-99-9       
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                         STATISTICAL ANALYSIS OF SURVIVAL DATA                              REPORT: PEIRPT11    
LAB: Battelle Northwest                                     TETRAHYDROFURAN                                    DATE: 02/20/96      
EXPERIMENT: 05181 TEST: 03                                                                                     TIME: 16:36:08      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01-ES-95259                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 60560C      
PATHOLOGIST: R. RENNE                                                                                          CAS: 0109-99-9      
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 37     CENSORED DEATHS 1    TERMINAL 12        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      244   406   422   453   508   514   526   546   547   549                 |
 |      551   554   562   563   563   573   575   587   602   621                 |
 |      621   635   635   639   649   649   660   661   663   673                 |
 |      683   683   705   723   729   729   729                                   |
 |  CENSORED DEATHS                                                               |
 |      73                                                                        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 43     CENSORED DEATHS 1    TERMINAL 6         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      439   502   503   514   514   519   523   528   540   540                 |
 |      551   551   551   552   575   575   579   607   607   614                 |
 |      624   626   629   630   635   639   639   643   646   653                 |
 |      660   660   672   677   691   701   707   715   719   719                 |
 |      719   729   729                                                           |
 |  CENSORED DEATHS                                                               |
 |      559                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 600 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 45     CENSORED DEATHS 0    TERMINAL 5         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      275   401   517   531   544   545   547   551   558   561                 |
 |      561   575   590   591   591   592   597   614   621   622                 |
 |      626   629   631   635   639   639   639   639   642   645                 |
 |      646   663   673   673   673   677   677   680   699   707                 |
 |      711   714   715   719   723                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1800 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 44     CENSORED DEATHS 0    TERMINAL 6         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      417   431   447   463   488   505   511   516   546   548                 |
 |      551   562   566   572   583   594   596   597   597   597                 |
 |      607   635   635   644   645   651   656   657   660   667                 |
 |      668   677   678   680   686   689   699   704   710   714                 |
 |      719   719   727   730                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  98.0  98.0  93.9  91.8  85.7  61.2  40.8  24.5      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |   100.0 100.0 100.0 100.0 100.0  98.0  80.0  65.8  35.0  12.3      |
 |           |                                                                    |
 |           |                                                                    |
 |600 PPM    |   100.0 100.0 100.0  98.0  96.0  96.0  88.0  66.0  36.0  10.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1800 PPM   |   100.0 100.0 100.0 100.0  98.0  92.0  84.0  60.0  42.0  12.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      200 PPM      600 PPM      1800 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       24.5%        12.3%        10.0%        12.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.538      P=0.290      P=0.204      P=0.330  |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       592.8        612.7        615.5        612.4    |
 |NATURAL DEATHS (C)      |       (16.7)       (11.5)       (12.5)       (12.9)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       616.0        626.1        627.3        626.8    |
 |(STANDARD ERROR)        |       (18.6)       (11.5)       (12.3)       (12.6)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      4     140   411   467   520   523   537   547   563   597                 |
 |      634   642   643   657   663   667   672   678   701   705                 |
 |      705   710   714   715   718                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 200 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      58    336   467   478   491   500   505   565   592   614                 |
 |      624   651   658   670   681   681   681   687   695   705                 |
 |      705   714   719   719   719                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 600 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      519   538   547   559   569   575   597   597   597   607                 |
 |      626   649   649   660   663   667   674   677   683   687                 |
 |      699   699   705   727                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS
                                                          

                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 1800 PPM                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 24     CENSORED DEATHS 0    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      412   420   478   498   523   532   549   575   588   597                 |
 |      624   629   630   634   641   643   646   661   691   691                 |
 |      691   699   705   714                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================
                                  TETRAHYDROFURAN

                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 733 DAYS

 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   733 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |    98.0  96.0  96.0  96.0  94.0  92.0  86.0  80.0  70.0  50.0      |
 |           |                                                                    |
 |           |                                                                    |
 |200 PPM    |    98.0  98.0  98.0  96.0  96.0  92.0  86.0  82.0  74.0  50.0      |
 |           |                                                                    |
 |           |                                                                    |
 |600 PPM    |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  82.0  70.0  52.0      |
 |           |                                                                    |
 |           |                                                                    |
 |1800 PPM   |   100.0 100.0 100.0 100.0  96.0  94.0  88.0  80.0  64.0  52.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                  DOSE                          |
 |                                                                                |
 |                                CONTROL      200 PPM      600 PPM      1800 PPM |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       50.0%        50.0%        52.0%        52.0%    |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=1.000N     P=1.000N     P=0.939N     P=1.000N |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       581.3        596.6        632.1        603.0    |
 |NATURAL DEATHS (C)      |       (35.2)       (30.4)       (12.2)       (18.0)   |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       657.2        664.8        684.6        670.6    |
 |(STANDARD ERROR)        |       (20.5)       (17.9)       ( 9.2)       (12.6)   |
 |                        |                                                       |
 ==================================================================================
                                    

       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
                                                          TETRAHYDROFURAN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        200 PPM          = 2
                                                        600 PPM          = 3
                                                        1800 PPM         = 4

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                      1    3                     4  2
      |                                        1    3                   1 4 42         2
      |                                                                 1  14 4 1 4    2 2  3
      |                                                                         1 4  4  1   3 3
   90 +                                                                              4  11 2
      |                                                                                  1  1 33
      |                                                                                 44 21 133
      |                                                                                       1133
   80 +                                                                                       22
      |                                                                                        113 3
P     |                                                                                         1143  3
E     |                                                                                        2  424
R  70 +                                                                                          11 4 4
C     |                                                                                           11  33
E     |                                                                                            11  3233
N     |                                                                                             1  122
T  60 +                                                                                                14212
      |                                                                                                 4 1 1
S     |                                                                                                    334
U     |                                                                                                    2114
R  50 +                                                                                                     211
V     |                                                                                                       14 1
I     |                                                                                                        4 4
V     |                                                                                                      22  44
A  40 +                                                                                                       22 1 11
L     |                                                                                                       3  344
      |                                                                                                          2231  1
      |                                                                                                           22   1  1
   30 +                                                                                                            242 2  1 1
      |                                                                                                              44
      |                                                                                                            33 3242  1
      |                                                                                                               33
   20 +                                                                                                                334
      |                                                                                                                  2  2
      |                                                                                                                 334 4
      |                                                                                                                  33 2
   10 +                                                                                                                   3 3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 54 obs hidden.
                                                          TETRAHYDROFURAN
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        200 PPM          = 2
                                                        600 PPM          = 3
                                                        1800 PPM         = 4

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  104 +
      |
      | 11        2                                                      4                 3
      |  1        2           1                              2           44                3 3
   96 +                       1                              2           14       2 4        3 3
      |                                                                  1        1 2  4       33
P     |                                                                           1 2 24   1    3 3
E     |                                                                               22   44     33
R  88 +                                                                                22  141 4   3   3
C     |                                                                                 2    1 1 2 4
E     |                                                                                        1 1 44 2
N     |                                                                                          1  4 2132
T  80 +                                                                                                132 21
      |                                                                                                    2112
S     |                                                                                                       22
U     |                                                                                                    44131 32
R  72 +                                                                                                     44 1 12 2
V     |                                                                                                          11
I     |                                                                                                      44   33
V     |                                                                                                       4  41122
A  64 +                                                                                                          4 13221
L     |                                                                                                             3322
      |                                                                                                              33
      |                                                                                                              4411
   56 +                                                                                                               3322
      |                                                                                                                3113
      |                                                                                                                 4 3 3
      |                                                                                                                  1  1
   48 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 29 obs hidden.