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TDMS Study 05182-04 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                                     PHENOLPHTHALEIN                                    DATE: 04/04/96       
EXPERIMENT: 05182 TEST: 04                                                                                     TIME: 04:07:17       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01-ES-05302                              ROUTE: DOSED FEED                                              NTP C#: 55798B       
PATHOLOGIST: A. RUSSFIELD                                                                                      CAS: 77-09-8         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                                     PHENOLPHTHALEIN                                    DATE: 04/04/96       
EXPERIMENT: 05182 TEST: 04                                                                                     TIME: 04:07:17       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05302                              ROUTE: DOSED FEED                                              NTP C#: 55798B       
PATHOLOGIST: A. RUSSFIELD                                                                                      CAS: 77-09-8         




                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                                    

                                                    ----------------

                                                    Adrenal Cortex
                                                    Adrenal Medulla
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: TSI Mason Research                                     PHENOLPHTHALEIN                                    DATE: 04/04/96       
EXPERIMENT: 05182 TEST: 04                                                                                     TIME: 04:07:17       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01-ES-05302                              ROUTE: DOSED FEED                                              NTP C#: 55798B       
PATHOLOGIST: A. RUSSFIELD                                                                                      CAS: 77-09-8         




                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                        IN THE ANALYSIS OF THE STUDY OF PHENOLPHTHALEIN

              ====================================================================================================

                                                           MALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Spleen                        Hemangiosarcoma
              All Organs                    Histiocytic Sarcoma
                                            Benign Tumors
                                            Malignant Tumors

              ====================================================================================================

                                                           FEMALE MICE
                                                          -------------
                  ORGAN                               MORPHOLOGY
                 -------                             ------------

              Liver                         Hepatocellular Adenoma
                                            Hepatocellular Carcinoma
                                            Hepatocellular Carcinoma or Hepatocellular Adenoma
                                            Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
              Lung                          Alveolar/Bronchiolar Adenoma
              Ovary                         Sex Cord Stromal Tumor, Benign
              All Organs                    Histiocytic Sarcoma
                                            Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated
                                             Cell Type
                                            Malignant Tumors
                                            Malignant and Benign Tumors

              ====================================================================================================
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE   1
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    3/50 (6%)    0/49 (0%)    0/48 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.5%         8.2%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/40 (3%)    2/33 (6%)    0/35 (0%)    0/35 (0%)  |  0/39 (0%)    0/31 (0%)    0/34 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      634          ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.168N     P=0.255      P=0.527N     P=0.527N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.198N     P=0.312      P=0.527N     P=0.527N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.158N     P=0.308      P=0.527N     P=0.527N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.156N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.316      P=0.500N     P=0.505N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/50 (6%)    2/50 (4%)    1/49 (2%)  |  2/50 (4%)    1/50 (2%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   7.5%         8.7%         5.6%         2.8%      |   5.0%         3.2%         2.9%         3.6%      |
|TERMINAL (d)           |  3/40 (8%)    2/33 (6%)    2/36 (6%)    1/36 (3%)  |  1/39 (3%)    1/31 (3%)    1/34 (3%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      714          729 (T)      729 (T)   |   730          737 (T)      737 (T)      737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.215N     P=0.574      P=0.548N     P=0.343N   |  P=0.500N     P=0.582N     P=0.550N     P=0.613N   |
|INCIDENTAL TUMOR       |  P=0.196N     P=0.641      P=0.548N     P=0.343N   |  P=0.457N     P=0.527N     P=0.485N     P=0.530N   |
|LOGISTIC REGRESSION    |  P=0.208N     P=0.613      P=0.548N     P=0.343N   |  P=0.493N     P=0.584N     P=0.555N     P=0.603N   |
|COCHRAN-ARMITAGE       |  P=0.199N                                          |  P=0.409N                                          |
|FISHER EXACT           |               P=0.661N     P=0.500N     P=0.316N   |               P=0.500N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE   2
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    1/49 (2%)  |  2/50 (4%)    0/50 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         5.6%         2.8%      |   5.1%         0.0%         0.0%         3.6%      |
|TERMINAL (d)           |  0/40 (0%)    0/33 (0%)    2/36 (6%)    1/36 (3%)  |  2/39 (5%)    0/31 (0%)    0/34 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          729 (T)      729 (T)   |   737 (T)      ---          ---          737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.237        (e)        P=0.215      P=0.479    |  P=0.533N     P=0.290N     P=0.269N     P=0.615N   |
|INCIDENTAL TUMOR       |  P=0.237        (e)        P=0.215      P=0.479    |  P=0.533N     P=0.290N     P=0.269N     P=0.615N   |
|LOGISTIC REGRESSION    |  P=0.237        (e)        P=0.215      P=0.479    |  P=0.533N     P=0.290N     P=0.269N     P=0.615N   |
|COCHRAN-ARMITAGE       |  P=0.241                                           |  P=0.461N                                          |
|FISHER EXACT           |                 (e)        P=0.247      P=0.495    |               P=0.247N     P=0.247N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    3/50 (6%)    4/50 (8%)    2/49 (4%)  |  4/50 (8%)    1/50 (2%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   7.5%         8.7%        11.1%         5.6%      |  10.0%         3.2%         2.9%         7.1%      |
|TERMINAL (d)           |  3/40 (8%)    2/33 (6%)    4/36 (11%)   2/36 (6%)  |  3/39 (8%)    1/31 (3%)    1/34 (3%)    2/28 (7%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      714          729 (T)      729 (T)   |   730          737 (T)      737 (T)      737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.451N     P=0.574      P=0.442      P=0.548N   |  P=0.422N     P=0.258N     P=0.227N     P=0.497N   |
|INCIDENTAL TUMOR       |  P=0.429N     P=0.641      P=0.442      P=0.548N   |  P=0.388N     P=0.224N     P=0.189N     P=0.436N   |
|LOGISTIC REGRESSION    |  P=0.444N     P=0.613      P=0.442      P=0.548N   |  P=0.414N     P=0.259N     P=0.230N     P=0.485N   |
|COCHRAN-ARMITAGE       |  P=0.431N                                          |  P=0.313N                                          |
|FISHER EXACT           |               P=0.661N     P=0.500      P=0.510N   |               P=0.181N     P=0.181N     P=0.339N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE   3
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/49 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         0.0%         5.3%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/40 (0%)    0/33 (0%)    1/36 (3%)    0/36 (0%)  |  0/39 (0%)    0/31 (0%)    0/34 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          713          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.583        (e)        P=0.217        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.636        (e)        P=0.300        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.590        (e)        P=0.227        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.591                                           |    (e)                                             |
|FISHER EXACT           |                 (e)        P=0.247        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    2/50 (4%)    2/50 (4%)    0/49 (0%)  |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.5%         5.4%         5.6%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/40 (3%)    0/33 (0%)    2/36 (6%)    0/36 (0%)  |  0/39 (0%)    0/31 (0%)    0/34 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      703          729 (T)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.319N     P=0.445      P=0.463      P=0.521N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.253N     P=0.638      P=0.463      P=0.521N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.304N     P=0.482      P=0.463      P=0.521N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.301N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.500      P=0.500      P=0.505N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE   4
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 22/50 (44%)  12/50 (24%)   8/50 (16%)  10/49 (20%) | 17/50 (34%)   2/50 (4%)    6/50 (12%)   1/50 (2%)  |
|ADJUSTED (b)           |  53.5%        29.3%        19.6%        25.0%      |  41.2%         6.5%        17.1%         3.6%      |
|TERMINAL (d)           | 21/40 (53%)   6/33 (18%)   5/36 (14%)   7/36 (19%) | 15/39 (38%)   2/31 (6%)    5/34 (15%)   1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   582          563          495          522       |   597          737 (T)      693          737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.017N*    P=0.103N     P=0.006N**   P=0.022N*  |  P<0.001N**   P=0.001N**   P=0.022N*    P<0.001N** |
|INCIDENTAL TUMOR       |  P=0.009N**   P=0.031N*    P=0.002N**   P=0.015N*  |  P<0.001N**   P<0.001N**   P=0.013N*    P<0.001N** |
|LOGISTIC REGRESSION    |  P=0.010N**   P=0.032N*    P=0.003N**   P=0.011N*  |  P<0.001N**   P<0.001N**   P=0.015N*    P<0.001N** |
|COCHRAN-ARMITAGE       |  P=0.010N**                                        |  P<0.001N**                                        |
|FISHER EXACT           |               P=0.028N*    P=0.002N**   P=0.010N*  |               P<0.001N**   P=0.008N**   P<0.001N** |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/50 (16%)  10/50 (20%)   5/50 (10%)   9/49 (18%) |  6/50 (12%)   1/50 (2%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |  19.5%        25.0%        11.8%        22.0%      |  14.9%         3.2%         0.0%         3.6%      |
|TERMINAL (d)           |  7/40 (18%)   5/33 (15%)   2/36 (6%)    5/36 (14%) |  5/39 (13%)   1/31 (3%)    0/34 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   727          560          500          639       |   708          737 (T)      ---          737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.508      P=0.275      P=0.343N     P=0.420    |  P=0.046N*    P=0.106N     P=0.028N*    P=0.128N   |
|INCIDENTAL TUMOR       |  P=0.546N     P=0.484      P=0.246N     P=0.560    |  P=0.038N*    P=0.089N     P=0.021N*    P=0.101N   |
|LOGISTIC REGRESSION    |  P=0.533      P=0.385      P=0.273N     P=0.474    |  P=0.042N*    P=0.099N     P=0.025N*    P=0.111N   |
|COCHRAN-ARMITAGE       |  P=0.533                                           |  P=0.025N*                                         |
|FISHER EXACT           |               P=0.398      P=0.277N     P=0.482    |               P=0.056N     P=0.013N*    P=0.056N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE   5
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 27/50 (54%)  20/50 (40%)  11/50 (22%)  16/49 (33%) | 21/50 (42%)   3/50 (6%)    6/50 (12%)   2/50 (4%)  |
|ADJUSTED (b)           |  64.2%        45.3%        25.8%        38.4%      |  49.8%         9.7%        17.1%         7.1%      |
|TERMINAL (d)           | 25/40 (63%)  10/33 (30%)   6/36 (17%)  11/36 (31%) | 18/39 (46%)   3/31 (10%)   5/34 (15%)   2/28 (7%)  |
|FIRST INCIDENCE (DAYS) |   582          560          495          522       |   597          737 (T)      693          737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.033N*    P=0.341N     P=0.005N**   P=0.060N   |  P<0.001N**   P<0.001N**   P=0.003N**   P<0.001N** |
|INCIDENTAL TUMOR       |  P=0.016N*    P=0.088N     P=0.001N**   P=0.032N*  |  P<0.001N**   P<0.001N**   P=0.001N**   P<0.001N** |
|LOGISTIC REGRESSION    |  P=0.016N*    P=0.123N     P=0.001N**   P=0.026N*  |  P<0.001N**   P<0.001N**   P=0.002N**   P<0.001N** |
|COCHRAN-ARMITAGE       |  P=0.016N*                                         |  P<0.001N**                                        |
|FISHER EXACT           |               P=0.115N     P<0.001N**   P=0.026N*  |               P<0.001N**   P<0.001N**   P<0.001N** |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 27/50 (54%)  20/50 (40%)  11/50 (22%)  16/49 (33%) | 21/50 (42%)   3/50 (6%)    6/50 (12%)   2/50 (4%)  |
|ADJUSTED (b)           |  64.2%        45.3%        25.8%        38.4%      |  49.8%         9.7%        17.1%         7.1%      |
|TERMINAL (d)           | 25/40 (63%)  10/33 (30%)   6/36 (17%)  11/36 (31%) | 18/39 (46%)   3/31 (10%)   5/34 (15%)   2/28 (7%)  |
|FIRST INCIDENCE (DAYS) |   582          560          495          522       |   597          737 (T)      693          737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.033N*    P=0.341N     P=0.005N**   P=0.060N   |  P<0.001N**   P<0.001N**   P=0.003N**   P<0.001N** |
|INCIDENTAL TUMOR       |  P=0.016N*    P=0.088N     P=0.001N**   P=0.032N*  |  P<0.001N**   P<0.001N**   P=0.001N**   P<0.001N** |
|LOGISTIC REGRESSION    |  P=0.016N*    P=0.123N     P=0.001N**   P=0.026N*  |  P<0.001N**   P<0.001N**   P=0.002N**   P<0.001N** |
|COCHRAN-ARMITAGE       |  P=0.016N*                                         |  P<0.001N**                                        |
|FISHER EXACT           |               P=0.115N     P<0.001N**   P=0.026N*  |               P<0.001N**   P<0.001N**   P<0.001N** |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE   6
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  8/50 (16%)  10/50 (20%)   4/50 (8%)   12/49 (24%) |  3/50 (6%)    1/50 (2%)    5/50 (10%)   6/50 (12%) |
|ADJUSTED (b)           |  20.0%        27.0%        10.5%        30.6%      |   7.2%         3.2%        14.7%        20.7%      |
|TERMINAL (d)           |  8/40 (20%)   7/33 (21%)   3/36 (8%)    9/36 (25%) |  2/39 (5%)    1/31 (3%)    5/34 (15%)   5/28 (18%) |
|FIRST INCIDENCE (DAYS) |   729 (T)      602          659          699       |   615          737 (T)      737 (T)      730       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.211      P=0.255      P=0.229N     P=0.162    |  P=0.032 *    P=0.385N     P=0.289      P=0.115    |
|INCIDENTAL TUMOR       |  P=0.251      P=0.353      P=0.196N     P=0.231    |  P=0.045 *    P=0.305N     P=0.328      P=0.186    |
|LOGISTIC REGRESSION    |  P=0.225      P=0.352      P=0.203N     P=0.185    |  P=0.041 *    P=0.328N     P=0.315      P=0.154    |
|COCHRAN-ARMITAGE       |  P=0.226                                           |  P=0.080                                           |
|FISHER EXACT           |               P=0.398      P=0.178N     P=0.212    |               P=0.309N     P=0.357      P=0.243    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    5/50 (10%)   4/50 (8%)    5/49 (10%) |  4/50 (8%)    4/50 (8%)    1/50 (2%)    2/50 (4%)  |
|ADJUSTED (b)           |   6.5%        14.2%        11.1%        13.5%      |   9.4%        12.3%         2.9%         5.6%      |
|TERMINAL (d)           |  0/40 (0%)    4/33 (12%)   4/36 (11%)   4/36 (11%) |  2/39 (5%)    3/31 (10%)   0/34 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   550          637          729 (T)      720       |   597          663          693          449       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.324      P=0.291      P=0.450      P=0.314    |  P=0.276N     P=0.514      P=0.231N     P=0.459N   |
|INCIDENTAL TUMOR       |  P=0.286      P=0.492      P=0.326      P=0.378    |  P=0.148N     P=0.642      P=0.118N     P=0.214N   |
|LOGISTIC REGRESSION    |  P=0.335      P=0.361      P=0.505      P=0.349    |  P=0.190N     P=0.607      P=0.180N     P=0.321N   |
|COCHRAN-ARMITAGE       |  P=0.337                                           |  P=0.186N                                          |
|FISHER EXACT           |               P=0.357      P=0.500      P=0.346    |               P=0.643N     P=0.181N     P=0.339N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE   7
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 11/50 (22%)  15/50 (30%)   8/50 (16%)  16/49 (33%) |  6/50 (12%)   5/50 (10%)   6/50 (12%)   8/50 (16%) |
|ADJUSTED (b)           |  25.2%        39.7%        21.3%        40.9%      |  13.8%        15.4%        17.1%        25.7%      |
|TERMINAL (d)           |  8/40 (20%)  11/33 (33%)   7/36 (19%)  13/36 (36%) |  3/39 (8%)    4/31 (13%)   5/34 (15%)   6/28 (21%) |
|FIRST INCIDENCE (DAYS) |   550          602          659          699       |   597          663          693          449       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.200      P=0.134      P=0.394N     P=0.126    |  P=0.133      P=0.597      P=0.522      P=0.198    |
|INCIDENTAL TUMOR       |  P=0.202      P=0.283      P=0.430N     P=0.180    |  P=0.243      P=0.489N     P=0.574N     P=0.435    |
|LOGISTIC REGRESSION    |  P=0.215      P=0.236      P=0.318N     P=0.160    |  P=0.213      P=0.542N     P=0.603      P=0.354    |
|COCHRAN-ARMITAGE       |  P=0.217                                           |  P=0.269                                           |
|FISHER EXACT           |               P=0.247      P=0.306N     P=0.168    |               P=0.500N     P=0.620N     P=0.387    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery                                                                                                                        |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)  |  0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         6.1%         0.0%         0.0%      |   0.0%         0.0%         2.2%         0.0%      |
|TERMINAL (d)           |  0/40 (0%)    2/33 (6%)    0/36 (0%)    0/36 (0%)  |  0/39 (0%)    0/31 (0%)    0/34 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      ---          ---       |   ---          ---          567          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.418N     P=0.197        (e)          (e)      |  P=0.688        (e)        P=0.491        (e)      |
|INCIDENTAL TUMOR       |  P=0.418N     P=0.197        (e)          (e)      |  P=0.720N       (e)        P=0.612        (e)      |
|LOGISTIC REGRESSION    |  P=0.418N     P=0.195        (e)          (e)      |  P=0.700        (e)        P=0.474        (e)      |
|COCHRAN-ARMITAGE       |  P=0.409N                                          |  P=0.694                                           |
|FISHER EXACT           |               P=0.247        (e)          (e)      |                 (e)        P=0.500        (e)      |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE   8
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    3/49 (6%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |                                                    |   0.0%         9.7%         0.0%         2.1%      |
|TERMINAL (d)           |                                                    |  0/39 (0%)    3/31 (10%)   0/34 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          737 (T)      ---          449       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.575      P=0.084        (e)        P=0.500    |
|INCIDENTAL TUMOR       |                                                    |  P=0.613N     P=0.084        (e)        P=0.814    |
|LOGISTIC REGRESSION    |                                                    |  P=0.626N     P=0.084        (e)        P=0.518    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.631N                                          |
|FISHER EXACT           |                                                    |               P=0.117        (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  2/50 (4%)    0/49 (0%)    0/50 (0%)    1/50 (2%)  |
|ADJUSTED (b)           |                                                    |   4.8%         0.0%         0.0%         3.6%      |
|TERMINAL (d)           |                                                    |  1/39 (3%)    0/31 (0%)    0/34 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   686          ---          ---          737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.532N     P=0.295N     P=0.272N     P=0.614N   |
|INCIDENTAL TUMOR       |                                                    |  P=0.469N     P=0.265N     P=0.209N     P=0.530N   |
|LOGISTIC REGRESSION    |                                                    |  P=0.497N     P=0.259N     P=0.244N     P=0.560N   |
|COCHRAN-ARMITAGE       |                                                    |  P=0.459N                                          |
|FISHER EXACT           |                                                    |               P=0.253N     P=0.247N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE   9
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Sex Cord Stromal Tumor, Benign                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  0/50 (0%)    7/49 (14%)   6/50 (12%)   5/50 (10%) |
|ADJUSTED (b)           |                                                    |   0.0%        21.7%        17.6%        17.9%      |
|TERMINAL (d)           |                                                    |  0/39 (0%)    6/31 (19%)   6/34 (18%)   5/28 (18%) |
|FIRST INCIDENCE (DAYS) |                                                    |   ---          668          737 (T)      737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.056      P=0.004 **   P=0.011 *    P=0.012 *  |
|INCIDENTAL TUMOR       |                                                    |  P=0.064      P=0.004 **   P=0.011 *    P=0.012 *  |
|LOGISTIC REGRESSION    |                                                    |  P=0.066      P=0.004 **   P=0.011 *    P=0.012 *  |
|COCHRAN-ARMITAGE       |                                                    |  P=0.142                                           |
|FISHER EXACT           |                                                    |               P=0.006 **   P=0.013 *    P=0.028 *  |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/48 (0%)    1/50 (2%)    0/49 (0%)    0/48 (0%)  |  3/49 (6%)    2/50 (4%)    1/49 (2%)    0/48 (0%)  |
|ADJUSTED (b)           |   0.0%         3.0%         0.0%         0.0%      |   7.9%         6.5%         2.9%         0.0%      |
|TERMINAL (d)           |  0/39 (0%)    1/33 (3%)    0/36 (0%)    0/36 (0%)  |  3/38 (8%)    2/31 (6%)    1/34 (3%)    0/27 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          729 (T)      ---          ---       |   737 (T)      737 (T)      737 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.572N     P=0.467        (e)          (e)      |  P=0.094N     P=0.593N     P=0.345N     P=0.187N   |
|INCIDENTAL TUMOR       |  P=0.572N     P=0.467        (e)          (e)      |  P=0.094N     P=0.593N     P=0.345N     P=0.187N   |
|LOGISTIC REGRESSION    |  P=0.572N     P=0.467        (e)          (e)      |  P=0.094N     P=0.594N     P=0.345N     P=0.187N   |
|COCHRAN-ARMITAGE       |  P=0.569N                                          |  P=0.064N                                          |
|FISHER EXACT           |               P=0.510        (e)          (e)      |               P=0.490N     P=0.309N     P=0.125N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE  10
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    0/50 (0%)    3/50 (6%)    0/49 (0%)  |  0/50 (0%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   2.5%         0.0%         7.4%         0.0%      |   0.0%         0.0%         2.9%         3.2%      |
|TERMINAL (d)           |  1/40 (3%)    0/33 (0%)    1/36 (3%)    0/36 (0%)  |  0/39 (0%)    0/31 (0%)    1/34 (3%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   729 (T)      ---          515          ---       |   ---          ---          737 (T)      715       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.515N     P=0.538N     P=0.275      P=0.521N   |  P=0.196        (e)        P=0.473      P=0.444    |
|INCIDENTAL TUMOR       |  P=0.437N     P=0.538N     P=0.477      P=0.521N   |  P=0.241        (e)        P=0.473      P=0.581    |
|LOGISTIC REGRESSION    |  P=0.496N     P=0.538N     P=0.307      P=0.521N   |  P=0.204        (e)        P=0.473      P=0.473    |
|COCHRAN-ARMITAGE       |  P=0.506N                                          |  P=0.236                                           |
|FISHER EXACT           |               P=0.500N     P=0.309      P=0.505N   |                 (e)        P=0.500      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    5/50 (10%)   1/50 (2%)    1/49 (2%)  |  0/50 (0%)    1/50 (2%)    2/50 (4%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%        14.0%         2.7%         2.8%      |   0.0%         3.2%         5.1%         3.2%      |
|TERMINAL (d)           |  0/40 (0%)    3/33 (9%)    0/36 (0%)    1/36 (3%)  |  0/39 (0%)    1/31 (3%)    1/34 (3%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          703          716          729 (T)   |   ---          737 (T)      567          715       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.500N     P=0.022 *    P=0.475      P=0.479    |  P=0.310      P=0.454      P=0.220      P=0.444    |
|INCIDENTAL TUMOR       |  P=0.409N     P=0.044 *    P=0.638      P=0.479    |  P=0.403      P=0.454      P=0.283      P=0.581    |
|LOGISTIC REGRESSION    |  P=0.484N     P=0.026 *    P=0.494      P=0.479    |  P=0.359      P=0.454      P=0.236      P=0.473    |
|COCHRAN-ARMITAGE       |  P=0.482N                                          |  P=0.366                                           |
|FISHER EXACT           |               P=0.028 *    P=0.500      P=0.495    |               P=0.500      P=0.247      P=0.500    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE  11
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Carcinoma or Papilloma Squamous                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    1/49 (2%)  |  1/50 (2%)    2/50 (4%)    0/50 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%         5.6%         2.8%      |   2.6%         6.5%         0.0%        10.7%      |
|TERMINAL (d)           |  0/40 (0%)    0/33 (0%)    2/36 (6%)    1/36 (3%)  |  1/39 (3%)    2/31 (6%)    0/34 (0%)    3/28 (11%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          729 (T)      729 (T)   |   737 (T)      737 (T)      ---          737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.237        (e)        P=0.215      P=0.479    |  P=0.164      P=0.420      P=0.527N     P=0.195    |
|INCIDENTAL TUMOR       |  P=0.237        (e)        P=0.215      P=0.479    |  P=0.164      P=0.420      P=0.527N     P=0.195    |
|LOGISTIC REGRESSION    |  P=0.237        (e)        P=0.215      P=0.479    |  P=0.164      P=0.420      P=0.527N     P=0.195    |
|COCHRAN-ARMITAGE       |  P=0.241                                           |  P=0.242                                           |
|FISHER EXACT           |                 (e)        P=0.247      P=0.495    |               P=0.500      P=0.500N     P=0.309    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    2/50 (4%)    0/49 (0%)  |  1/50 (2%)    1/50 (2%)    0/50 (0%)    3/50 (6%)  |
|ADJUSTED (b)           |   0.0%         0.0%         5.6%         0.0%      |   2.6%         3.2%         0.0%        10.7%      |
|TERMINAL (d)           |  0/40 (0%)    0/33 (0%)    2/36 (6%)    0/36 (0%)  |  1/39 (3%)    1/31 (3%)    0/34 (0%)    3/28 (11%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          729 (T)      ---       |   737 (T)      737 (T)      ---          737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.582        (e)        P=0.215        (e)      |  P=0.105      P=0.710      P=0.527N     P=0.195    |
|INCIDENTAL TUMOR       |  P=0.582        (e)        P=0.215        (e)      |  P=0.105      P=0.710      P=0.527N     P=0.195    |
|LOGISTIC REGRESSION    |  P=0.582        (e)        P=0.215        (e)      |  P=0.105      P=0.710      P=0.527N     P=0.195    |
|COCHRAN-ARMITAGE       |  P=0.591                                           |  P=0.160                                           |
|FISHER EXACT           |                 (e)        P=0.247        (e)      |               P=0.753N     P=0.500N     P=0.309    |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE  12
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/49 (0%)    1/50 (2%)    2/50 (4%)    0/49 (0%)  |  1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   0.0%         2.1%         5.3%         0.0%      |   2.6%         6.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/39 (0%)    0/33 (0%)    1/36 (3%)    0/36 (0%)  |  1/39 (3%)    1/31 (3%)    0/34 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          563          713          ---       |   737 (T)      663          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.623N     P=0.500      P=0.220        (e)      |  P=0.234N     P=0.423      P=0.527N     P=0.566N   |
|INCIDENTAL TUMOR       |  P=0.642N     P=0.638      P=0.303        (e)      |  P=0.196N     P=0.473      P=0.527N     P=0.566N   |
|LOGISTIC REGRESSION    |  P=0.608N     P=0.472      P=0.232        (e)      |  P=0.204N     P=0.467      P=0.527N     P=0.566N   |
|COCHRAN-ARMITAGE       |  P=0.618N                                          |  P=0.188N                                          |
|FISHER EXACT           |               P=0.505      P=0.253        (e)      |               P=0.500      P=0.500N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/49 (2%)    1/50 (2%)    2/50 (4%)    0/49 (0%)  |  1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)  |
|ADJUSTED (b)           |   2.3%         2.1%         5.3%         0.0%      |   2.6%         6.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/39 (0%)    0/33 (0%)    1/36 (3%)    0/36 (0%)  |  1/39 (3%)    1/31 (3%)    0/34 (0%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   662          563          713          ---       |   737 (T)      663          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.379N     P=0.750      P=0.474      P=0.514N   |  P=0.234N     P=0.423      P=0.527N     P=0.566N   |
|INCIDENTAL TUMOR       |  P=0.348N     P=0.599N     P=0.651      P=0.362N   |  P=0.196N     P=0.473      P=0.527N     P=0.566N   |
|LOGISTIC REGRESSION    |  P=0.355N     P=0.759      P=0.506      P=0.493N   |  P=0.204N     P=0.467      P=0.527N     P=0.566N   |
|COCHRAN-ARMITAGE       |  P=0.367N                                          |  P=0.188N                                          |
|FISHER EXACT           |               P=0.747N     P=0.508      P=0.500N   |               P=0.500      P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE  13
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/50 (2%)    2/50 (4%)    3/50 (6%)    1/50 (2%)  |
|ADJUSTED (b)           |                                                    |   2.6%         6.2%         8.8%         3.6%      |
|TERMINAL (d)           |                                                    |  1/39 (3%)    1/31 (3%)    3/34 (9%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   737 (T)      703          737 (T)      737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.521      P=0.419      P=0.257      P=0.686    |
|INCIDENTAL TUMOR       |                                                    |  P=0.557      P=0.473      P=0.257      P=0.686    |
|LOGISTIC REGRESSION    |                                                    |  P=0.541      P=0.440      P=0.257      P=0.686    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.577N                                          |
|FISHER EXACT           |                                                    |               P=0.500      P=0.309      P=0.753N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)  |  2/50 (4%)    0/50 (0%)    1/50 (2%)    1/50 (2%)  |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   4.8%         0.0%         2.2%         3.6%      |
|TERMINAL (d)           |  0/40 (0%)    0/33 (0%)    0/36 (0%)    0/36 (0%)  |  1/39 (3%)    0/31 (0%)    0/34 (0%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   686          ---          567          737 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.564N     P=0.295N     P=0.538N     P=0.614N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.461N     P=0.239N     P=0.406N     P=0.530N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.502N     P=0.255N     P=0.499N     P=0.560N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.500N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.247N     P=0.500N     P=0.500N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE  14
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    6/50 (12%)   7/50 (14%)   2/49 (4%)  |  0/50 (0%)    1/50 (2%)    4/50 (8%)    1/50 (2%)  |
|ADJUSTED (b)           |   7.3%        16.9%        18.0%         5.6%      |   0.0%         3.2%        10.8%         3.2%      |
|TERMINAL (d)           |  2/40 (5%)    4/33 (12%)   5/36 (14%)   2/36 (6%)  |  0/39 (0%)    1/31 (3%)    3/34 (9%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   724          703          515          729 (T)   |   ---          737 (T)      567          715       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.380N     P=0.166      P=0.125      P=0.552N   |  P=0.263      P=0.454      P=0.051      P=0.444    |
|INCIDENTAL TUMOR       |  P=0.287N     P=0.285      P=0.244      P=0.477N   |  P=0.334      P=0.454      P=0.067      P=0.581    |
|LOGISTIC REGRESSION    |  P=0.351N     P=0.197      P=0.154      P=0.534N   |  P=0.312      P=0.454      P=0.062      P=0.473    |
|COCHRAN-ARMITAGE       |  P=0.350N                                          |  P=0.337                                           |
|FISHER EXACT           |               P=0.243      P=0.159      P=0.510N   |               P=0.500      P=0.059      P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/50 (6%)    6/50 (12%)   7/50 (14%)   2/49 (4%)  |  2/50 (4%)    1/50 (2%)    4/50 (8%)    2/50 (4%)  |
|ADJUSTED (b)           |   7.3%        16.9%        18.0%         5.6%      |   4.8%         3.2%        10.8%         6.7%      |
|TERMINAL (d)           |  2/40 (5%)    4/33 (12%)   5/36 (14%)   2/36 (6%)  |  1/39 (3%)    1/31 (3%)    3/34 (9%)    1/28 (4%)  |
|FIRST INCIDENCE (DAYS) |   724          703          515          729 (T)   |   686          737 (T)      567          715       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.380N     P=0.166      P=0.125      P=0.552N   |  P=0.368      P=0.583N     P=0.285      P=0.575    |
|INCIDENTAL TUMOR       |  P=0.287N     P=0.285      P=0.244      P=0.477N   |  P=0.466      P=0.527N     P=0.369      P=0.687N   |
|LOGISTIC REGRESSION    |  P=0.351N     P=0.197      P=0.154      P=0.534N   |  P=0.435      P=0.548N     P=0.332      P=0.640    |
|COCHRAN-ARMITAGE       |  P=0.350N                                          |  P=0.477                                           |
|FISHER EXACT           |               P=0.243      P=0.159      P=0.510N   |               P=0.500N     P=0.339      P=0.691N   |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE  15
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/50 (2%)    3/50 (6%)   11/50 (22%)  12/49 (24%) |  0/50 (0%)    2/50 (4%)    7/50 (14%)   7/50 (14%) |
|ADJUSTED (b)           |   2.4%         7.9%        28.0%        27.5%      |   0.0%         6.5%        17.6%        18.0%      |
|TERMINAL (d)           |  0/40 (0%)    0/33 (0%)    8/36 (22%)   5/36 (14%) |  0/39 (0%)    2/31 (6%)    3/34 (9%)    0/28 (0%)  |
|FIRST INCIDENCE (DAYS) |   727          658          665          549       |   ---          737 (T)      567          588       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.255      P=0.002 **   P=0.002 ** |  P=0.002 **   P=0.189      P=0.007 **   P=0.005 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.582      P=0.005 **   P=0.003 ** |  P=0.011 *    P=0.189      P=0.015 *    P=0.052    |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.302      P=0.002 **   P=0.001 ** |  P=0.009 **   P=0.189      P=0.010 **   P=0.011 *  |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P=0.004 **                                        |
|FISHER EXACT           |               P=0.309      P=0.002 **   P<0.001 ** |               P=0.247      P=0.006 **   P=0.006 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed, NOS, or Undifferentiated                                               |
|     Cell Type                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/50 (12%)   8/50 (16%)  12/50 (24%)   8/49 (16%) | 15/50 (30%)  28/50 (56%)  33/50 (66%)  25/50 (50%) |
|ADJUSTED (b)           |  14.5%        19.1%        27.2%        22.2%      |  34.3%        60.2%        74.6%        65.8%      |
|TERMINAL (d)           |  5/40 (13%)   3/33 (9%)    6/36 (17%)   8/36 (22%) | 11/39 (28%)  13/31 (42%)  23/34 (68%)  16/28 (57%) |
|FIRST INCIDENCE (DAYS) |   662          347          423          729 (T)   |   156          266          338          447       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.299      P=0.300      P=0.082      P=0.309    |  P=0.010 *    P=0.003 **   P<0.001 **   P=0.004 ** |
|INCIDENTAL TUMOR       |  P=0.330      P=0.488      P=0.267      P=0.347    |  P=0.101      P=0.026 *    P<0.001 **   P=0.043 *  |
|LOGISTIC REGRESSION    |  P=0.324      P=0.396      P=0.101      P=0.353    |  P=0.114      P=0.051      P<0.001 **   P=0.035 *  |
|COCHRAN-ARMITAGE       |  P=0.310                                           |  P=0.060                                           |
|FISHER EXACT           |               P=0.387      P=0.096      P=0.371    |               P=0.007 **   P<0.001 **   P=0.033 *  |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE  16
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 29/50 (58%)  24/50 (48%)  18/50 (36%)  19/49 (39%) | 26/50 (52%)  20/50 (40%)  23/50 (46%)  17/50 (34%) |
|ADJUSTED (b)           |  68.9%        55.0%        43.3%        45.9%      |  58.8%        58.7%        61.7%        56.1%      |
|TERMINAL (d)           | 27/40 (68%)  14/33 (42%)  13/36 (36%)  14/36 (39%) | 21/39 (54%)  17/31 (55%)  20/34 (59%)  15/28 (54%) |
|FIRST INCIDENCE (DAYS) |   582          563          495          522       |    78          663          479          449       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.058N     P=0.521N     P=0.066N     P=0.095N   |  P=0.372N     P=0.509N     P=0.566      P=0.389N   |
|INCIDENTAL TUMOR       |  P=0.026N*    P=0.203N     P=0.019N*    P=0.043N*  |  P=0.204N     P=0.346N     P=0.451N     P=0.202N   |
|LOGISTIC REGRESSION    |  P=0.030N*    P=0.234N     P=0.027N*    P=0.043N*  |  P=0.208N     P=0.431N     P=0.559N     P=0.199N   |
|COCHRAN-ARMITAGE       |  P=0.030N*                                         |  P=0.067N                                          |
|FISHER EXACT           |               P=0.212N     P=0.022N*    P=0.043N*  |               P=0.158N     P=0.345N     P=0.053N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 19/50 (38%)  29/50 (58%)  35/50 (70%)  29/49 (59%) | 25/50 (50%)  35/50 (70%)  41/50 (82%)  37/50 (74%) |
|ADJUSTED (b)           |  41.2%        61.3%        71.4%        63.0%      |  55.1%        71.4%        85.4%        78.5%      |
|TERMINAL (d)           | 13/40 (33%)  15/33 (45%)  22/36 (61%)  19/36 (53%) | 19/39 (49%)  17/31 (55%)  27/34 (79%)  18/28 (64%) |
|FIRST INCIDENCE (DAYS) |   550          347          423          549       |   156          266          338          447       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.057      P=0.021 *    P=0.002 **   P=0.030 *  |  P=0.002 **   P=0.011 *    P<0.001 **   P=0.001 ** |
|INCIDENTAL TUMOR       |  P=0.039 *    P=0.128      P=0.003 **   P=0.047 *  |  P=0.041 *    P=0.097      P=0.001 **   P=0.056    |
|LOGISTIC REGRESSION    |  P=0.026 *    P=0.039 *    P=0.001 **   P=0.035 *  |  P=0.040 *    P=0.166      P<0.001 **   P=0.058    |
|COCHRAN-ARMITAGE       |  P=0.031 *                                         |  P=0.010 *                                         |
|FISHER EXACT           |               P=0.036 *    P=0.001 **   P=0.028 *  |               P=0.033 *    P<0.001 **   P=0.011 *  |
|=================================================================================================================================|
         DATE: 04/04/96                     EXPERIMENT: 05182 TEST: 04                                                 PAGE  17
                               STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- PHENOLPHTHALEIN

                                                 MALE TERMINAL SACRIFICE AT 105 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS

|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        3000 PPM     6000 PPM     12000     |   0 PPM        3000 PPM     6000 PPM     12000     |
|                       |                                          PPM       |                                          PPM       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 40/50 (80%)  40/50 (80%)  42/50 (84%)  38/49 (78%) | 40/50 (80%)  40/50 (80%)  47/50 (94%)  43/50 (86%) |
|ADJUSTED (b)           |  83.3%        81.6%        84.0%        80.8%      |  83.3%        81.6%        95.9%        91.4%      |
|TERMINAL (d)           | 32/40 (80%)  24/33 (73%)  28/36 (78%)  27/36 (75%) | 31/39 (79%)  22/31 (71%)  32/34 (94%)  24/28 (86%) |
|FIRST INCIDENCE (DAYS) |   550          347          423          522       |    78          266          338          447       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.516      P=0.194      P=0.211      P=0.459    |  P=0.014 *    P=0.135      P=0.024 *    P=0.014 *  |
|INCIDENTAL TUMOR       |  P=0.378N     P=0.369N     P=0.519      P=0.395N   |  P=0.269      P=0.477N     P=0.053      P=0.374    |
|LOGISTIC REGRESSION    |  P=0.461N     P=0.590      P=0.392      P=0.502N   |  P=0.230      P=0.566N     P=0.037 *    P=0.282    |
|COCHRAN-ARMITAGE       |  P=0.443N                                          |  P=0.158                                           |
|FISHER EXACT           |               P=0.598N     P=0.398      P=0.479N   |               P=0.598N     P=0.036 *    P=0.298    |
|=================================================================================================================================|

 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.

  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).