Skip to Main Navigation
Skip to Page Content
Share This:
https://ntp.niehs.nih.gov/go/2046

TDMS Study 05182-03 Pathology Tables

NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96
Route: DOSED FEED                                                                                                 Time: 03:10:02




       Facility:  TSI Mason Research

       Chemical CAS #:  77-09-8

       Lock Date:  01/24/94

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9            8            7            8                                     
    Natural Death                                     11            4           11            4                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           38           32           38                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (49)         (49)                                   
      Parasite Metazoan                                1 (2%)       2 (4%)       2 (4%)       2 (4%)                                
   Intestine Large, Rectum                            (49)         (47)         (48)         (49)                                   
      Edema                                            1 (2%)                                                                       
      Inflammation, Acute                              1 (2%)                                                                       
      Parasite Metazoan                                4 (8%)                                                                       
   Intestine Large, Cecum                             (45)         (49)         (47)         (48)                                   
      Edema                                            1 (2%)       3 (6%)                                                          
      Necrosis                                         1 (2%)                                                                       
   Intestine Small, Duodenum                          (46)         (49)         (49)         (48)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (44)         (49)         (47)         (48)                                   
      Ulcer, Focal                                                                            1 (2%)                                
   Intestine Small, Ileum                             (47)         (49)         (45)         (49)                                   
      Necrosis                                                                   1 (2%)                                             
      Ulcer, Focal                                                                            1 (2%)                                
   Liver                                              (50)         (50)         (50)         (49)                                   
      Angiectasis, Focal                               1 (2%)       4 (8%)       4 (8%)                                             
      Basophilic Focus                                32 (64%)     34 (68%)     34 (68%)     34 (69%)                               
      Clear Cell Focus                                 2 (4%)       3 (6%)       3 (6%)       1 (2%)                                
      Cytoplasmic Alteration, Focal                                 1 (2%)                                                          
      Eosinophilic Focus                              12 (24%)     12 (24%)     12 (24%)      4 (8%)                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 3 (6%)       2 (4%)       1 (2%)       1 (2%)                                
      Hepatodiaphragmatic Nodule                       3 (6%)       7 (14%)      6 (12%)      4 (8%)                                
      Hyperplasia, Focal                                                                      1 (2%)                                
      Infiltration Cellular, Focal, Lymphocyte                      1 (2%)                                                          
      Inflammation, Chronic                            7 (14%)      3 (6%)       4 (8%)       4 (8%)                                
      Mixed Cell Focus                                25 (50%)     23 (46%)     31 (62%)     33 (67%)                               
      Necrosis                                         2 (4%)                    1 (2%)                                             
      Bile Duct, Hyperplasia, Focal                    1 (2%)                                                                       
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic            3 (6%)       1 (2%)       3 (6%)       6 (12%)                               
      Kupffer Cell, Hyperplasia, Diffuse               1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (12)         (7)          (6)          (7)                                    
      Accessory Spleen                                 1 (8%)                                 1 (14%)                               
      Fat, Necrosis                                   10 (83%)      7 (100%)     6 (100%)     5 (71%)                               
   Oral Mucosa                                                     (3)                                                              
      Ulcer                                                         1 (33%)                                                         
   Pancreas                                           (49)         (49)         (49)         (46)                                   
      Acinus, Atrophy, Diffuse                         4 (8%)       1 (2%)       1 (2%)       2 (4%)                                
      Acinus, Atrophy, Focal                          17 (35%)     28 (57%)     30 (61%)     22 (48%)                               
      Acinus, Basophilic Focus                                      1 (2%)                                                          
      Acinus, Hyperplasia, Focal                                                 2 (4%)       1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (49)                                   
      Atrophy, Diffuse                                              1 (2%)                                                          
      Infiltration Cellular, Focal, Lymphocyte                      1 (2%)                                                          
      Parotid Gland, Atrophy, Diffuse                  2 (4%)                                                                       
      Parotid Gland, Atrophy, Focal                                 1 (2%)       2 (4%)       1 (2%)                                
      Submandibular Gland, Atrophy, Diffuse            1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (50)         (50)         (49)                                   
      Inflammation, Chronic                            1 (2%)       2 (4%)       1 (2%)                                             
      Ulcer, Focal                                                               3 (6%)       1 (2%)                                
      Epithelium, Hyperplasia                          4 (8%)       3 (6%)       4 (8%)       2 (4%)                                
   Stomach, Glandular                                 (48)         (50)         (50)         (48)                                   
      Erosion, Focal                                   6 (13%)      2 (4%)       1 (2%)       2 (4%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Glands, Cyst, Focal                              8 (17%)      9 (18%)     21 (42%)      4 (8%)                                
      Serosa, Inflammation, Acute                                                1 (2%)                                             
   Tongue                                             (2)          (3)                       (2)                                    
      Capillary, Erosion, Focal                                     1 (33%)                   1 (50%)                               
   Tooth                                              (1)                       (2)                                                 
      Developmental Malformation                                                 1 (50%)                                            
      Gingiva, Inflammation, Chronic                                             1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (50)         (50)         (50)                                   
      Aorta, Media, Mineralization                     1 (2%)                                                                       
   Heart                                              (50)         (50)         (50)         (49)                                   
      Cardiomyopathy                                  36 (72%)     32 (64%)     34 (68%)     27 (55%)                               
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
      Atrium, Thrombosis                               2 (4%)                                                                       
      Myocardium, Inflammation, Acute, Focal                                     1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (49)                                   
      Hematopoietic Cell Proliferation                                                        1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Focal                               2 (4%)       5 (10%)      5 (10%)      6 (12%)                               
      Hypertrophy, Focal                               2 (4%)       1 (2%)       3 (6%)       3 (6%)                                
      Inflammation, Acute, Focal                                                              1 (2%)                                
      Pigmentation                                     1 (2%)                                                                       
      Vacuolization Cytoplasmic, Focal                 6 (12%)     17 (34%)     18 (37%)     10 (20%)                               
      Bilateral, Hematopoietic Cell Proliferation                   1 (2%)                                                          
      Bilateral, Hyperplasia, Focal                    1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Bilateral, Necrosis                              2 (4%)       2 (4%)       1 (2%)                                             
      Bilateral, Vacuolization Cytoplasmic, Focal                                2 (4%)       1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (49)                                   
      Hyperplasia, Focal                               9 (18%)     14 (28%)     15 (30%)     11 (22%)                               
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Bilateral, Hyperplasia, Focal                    1 (2%)       4 (8%)                                                          
   Islets, Pancreatic                                 (49)         (49)         (49)         (47)                                   
      Metaplasia, Focal                                1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (46)         (46)         (47)         (44)                                   
      Hyperplasia, Focal                               1 (2%)       1 (2%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (49)         (50)         (47)                                   
      Pars Distalis, Angiectasis, Focal                1 (2%)       1 (2%)       1 (2%)       5 (11%)                               
      Pars Distalis, Cyst                             14 (28%)     17 (35%)     16 (32%)     11 (23%)                               
      Pars Distalis, Hyperplasia, Focal                5 (10%)      2 (4%)       2 (4%)       4 (9%)                                
      Pars Distalis, Pigmentation                      1 (2%)                    1 (2%)                                             
      Rathke's Cleft, Cyst                                          1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)         (48)                                   
      Ultimobranchial Cyst                                          1 (2%)                    2 (4%)                                
      C-Cell, Hyperplasia, Diffuse                     1 (2%)                                                                       
      C-Cell, Hyperplasia, Focal                      20 (40%)     18 (36%)     17 (34%)      9 (19%)                               
      Follicle, Cyst                                   1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Follicle, Hyperplasia, Focal                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (50)         (50)         (49)         (48)                                   
      Cyst                                                          1 (2%)       1 (2%)                                             
      Hyperplasia, Focal                               1 (2%)       4 (8%)       4 (8%)       3 (6%)                                
      Inflammation, Chronic                            4 (8%)       4 (8%)       8 (16%)      7 (15%)                               
      Inflammation, Chronic Active                     3 (6%)       3 (6%)       1 (2%)       5 (10%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Bilateral, Atrophy                               1 (2%)       2 (4%)                                                          
      Bilateral, Hyperplasia, Focal                                              1 (2%)                                             
      Duct, Hyperplasia, Focal                         1 (2%)                                                                       
      Duct, Inflammation, Acute                                     1 (2%)                                                          
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                                                       1 (2%)                                             
      Bilateral, Atrophy                                                                      1 (2%)                                
      Bilateral, Cyst                                                                         1 (2%)                                
      Bilateral, Pigmentation                                       1 (2%)                                                          
      Bursa, Cyst                                      1 (2%)       4 (8%)       4 (8%)       6 (12%)                               
      Follicle, Cyst                                                2 (4%)       2 (4%)       4 (8%)                                
      Periovarian Tissue, Cyst                                      1 (2%)                                                          
   Oviduct                                                                                   (1)                                    
      Cyst                                                                                    1 (100%)                              
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Hydrometra                                       4 (8%)       4 (8%)       3 (6%)       6 (12%)                               
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Thrombosis                                                                              1 (2%)                                
      Endometrium, Atrophy                             1 (2%)                                                                       
      Endometrium, Cyst                                             1 (2%)       1 (2%)       4 (8%)                                
      Endometrium, Inflammation, Acute                 2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Atrophy                                          1 (2%)       1 (2%)       3 (6%)       5 (10%)                               
      Hyperplasia                                      6 (12%)      9 (18%)      4 (8%)       6 (12%)                               
      Myelofibrosis                                    5 (10%)      1 (2%)       2 (4%)       2 (4%)                                
   Lymph Node                                         (7)          (11)         (9)          (9)                                    
      Iliac, Hemorrhage                                                          1 (11%)                                            
      Iliac, Hyperplasia, Lymphoid                                               1 (11%)                                            
      Mediastinal, Hemorrhage                          1 (14%)                                1 (11%)                               
      Mediastinal, Pigmentation                                                               1 (11%)                               
      Renal, Infiltration Cellular, Histiocyte         1 (14%)                                                                      
   Lymph Node, Mandibular                             (50)         (50)         (50)         (48)                                   
      Degeneration, Cystic                             6 (12%)     11 (22%)      2 (4%)       8 (17%)                               
      Hemorrhage                                       2 (4%)                                 1 (2%)                                
      Hyperplasia, Lymphoid                           14 (28%)      4 (8%)       6 (12%)      5 (10%)                               
      Infiltration Cellular, Histiocyte                4 (8%)       3 (6%)       1 (2%)       3 (6%)                                
      Necrosis                                         1 (2%)                                                                       
      Pigmentation                                     1 (2%)       1 (2%)                    1 (2%)                                
   Lymph Node, Mesenteric                             (49)         (50)         (49)         (48)                                   
      Degeneration, Cystic                             2 (4%)       1 (2%)       4 (8%)       1 (2%)                                
      Ectasia                                          1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       2 (4%)       2 (4%)       2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            2 (4%)                                 1 (2%)                                
      Infiltration Cellular, Histiocyte               30 (61%)     33 (66%)     31 (63%)     26 (54%)                               
      Pigmentation                                                  1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Congestion                                                                              1 (2%)                                
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 9 (18%)      7 (14%)      6 (12%)      6 (12%)                               
      Pigmentation                                     8 (16%)      7 (14%)     10 (20%)      6 (12%)                               
      Lymphoid Follicle, Atrophy                       3 (6%)                                                                       
   Thymus                                             (50)         (49)         (49)         (48)                                   
      Cyst                                                          1 (2%)       1 (2%)                                             
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Epithelial Cell, Hyperplasia                    20 (40%)     34 (69%)     31 (63%)     23 (48%)                               
      Thymocyte, Atrophy                              21 (42%)     19 (39%)     20 (41%)     23 (48%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (48)         (49)                                   
      Galactocele                                     22 (44%)     15 (30%)     14 (29%)     17 (35%)                               
      Inflammation, Chronic                                         2 (4%)                                                          
      Epithelium, Hyperplasia                                       1 (2%)                    1 (2%)                                
   Skin                                               (50)         (50)         (49)         (50)                                   
      Subcutaneous Tissue, Fibrosis, Focal                                       1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Acute                                   1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Chronic,                                                                                   
           Focal                                                                              1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Acute                                           1 (2%)                                                          
      Femur, Fibrous Osteodystrophy                    1 (2%)                                                                       
      Femur, Hyperostosis                              7 (14%)      2 (4%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hydrocephalus                                    1 (2%)       1 (2%)       5 (10%)                                            
      Cerebellum, Hemorrhage, Focal                                 1 (2%)                                                          
      Cerebrum, Hemorrhage, Focal                                   1 (2%)       1 (2%)       1 (2%)                                
      Meninges, Cerebrum, Hemorrhage                                                          1 (2%)                                
      Pons, Hemorrhage, Focal                                       1 (2%)                                                          
      Thalamus, Cerebrum, Necrosis                                  1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
   Peripheral Nerve                                   (1)          (2)          (2)          (2)                                    
      Sciatic, Degeneration                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                                               1 (2%)                                             
      Hemorrhage                                       2 (4%)       1 (2%)       8 (16%)      4 (8%)                                
      Infiltration Cellular, Focal, Lymphocyte                      1 (2%)                                                          
      Infiltration Cellular, Focal, Histiocyte                                                1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          4 (8%)       5 (10%)                                                         
      Interstitium, Inflammation, Chronic              6 (12%)      5 (10%)      6 (12%)      6 (12%)                               
      Interstitium, Inflammation, Chronic Active                    1 (2%)                                                          
      Serosa, Inflammation, Chronic                                              1 (2%)                                             
   Nose                                               (50)         (49)         (50)         (50)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute                                           1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            5 (10%)      2 (4%)       2 (4%)       4 (8%)                                
      Inflammation, Chronic Active                     1 (2%)       6 (12%)      3 (6%)       1 (2%)                                
      Nasolacrimal Duct, Inflammation, Acute                        2 (4%)       2 (4%)       2 (4%)                                
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                                                              1 (2%)                                
      Olfactory Epithelium, Cytoplasmic Alteration     3 (6%)       6 (12%)      3 (6%)       2 (4%)                                
      Turbinate, Congestion                            1 (2%)                                                                       
   Trachea                                            (50)         (50)         (50)         (49)                                   
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       3 (6%)       2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)          (1)          (2)                                                 
      Atrophy                                                       1 (100%)                                                        
      Cornea, Inflammation, Chronic                    1 (50%)                   1 (50%)                                            
      Lens, Cataract                                   1 (50%)                   2 (100%)                                           
      Retina, Atrophy                                  1 (50%)                   2 (100%)                                           
   Zymbal's Gland                                                  (1)                       (1)                                    
      Cyst                                                                                    1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                          2 (4%)                    1 (2%)                                
      Ectopic Liver                                                                           1 (2%)                                
      Fibrosis, Focal                                  1 (2%)       1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                    1 (2%)                                             
      Mineralization, Focal                            3 (6%)       3 (6%)       5 (10%)      3 (6%)                                
      Nephropathy, Chronic                             4 (8%)       1 (2%)                    2 (4%)                                
      Bilateral, Mineralization, Focal                 7 (14%)      5 (10%)      9 (18%)      5 (10%)                               
      Bilateral, Nephropathy, Chronic                 30 (60%)     44 (88%)     43 (86%)     42 (84%)                               
      Bilateral, Pelvis, Dilatation                    1 (2%)                                                                       
      Bilateral, Pelvis, Inflammation, Acute           1 (2%)                                                                       
      Bilateral, Pelvis, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)                                                                       
      Bilateral, Pelvis, Mineralization, Focal                                   1 (2%)                                             
      Bilateral, Pelvis, Transitional Epithelium,                                                                                   
           Hyperplasia                                 2 (4%)                                                                       
      Bilateral, Renal Tubule, Accumulation,                                                                                        
          Hyaline Droplet                                                                     2 (4%)                                
      Bilateral, Renal Tubule, Pigmentation           11 (22%)      9 (18%)      7 (14%)      8 (16%)                               
      Papilla, Necrosis                                1 (2%)                                                                       
      Pelvis, Dilatation                                                         1 (2%)                                             
      Pelvis, Inflammation, Acute                                   2 (4%)                                                          
      Pelvis, Transitional Epithelium, Hyperplasia                  1 (2%)       1 (2%)                                             
      Renal Tubule, Degeneration                       1 (2%)                                                                       
   Urinary Bladder                                    (49)         (49)         (49)         (49)                                   
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                15           15           13           16                                     
    Natural Death                                     14           20           22           21                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                21           15           14           13                                     
    Natural Death                                                                1                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (48)         (49)         (49)         (48)                                   
      Parasite Metazoan                                1 (2%)       2 (4%)       4 (8%)       3 (6%)                                
      Muscularis, Necrosis, Focal                                                             1 (2%)                                
   Intestine Large, Rectum                            (48)         (49)         (50)         (50)                                   
      Necrosis                                                      1 (2%)                                                          
      Parasite Metazoan                                1 (2%)       2 (4%)                                                          
   Intestine Large, Cecum                             (44)         (41)         (44)         (40)                                   
      Edema                                                         3 (7%)       1 (2%)       1 (3%)                                
      Erosion, Focal                                                                          1 (3%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis                                                                   1 (2%)       1 (3%)                                
      Artery, Inflammation, Chronic                                 2 (5%)                    1 (3%)                                
      Epithelium, Hyperplasia                                                                 1 (3%)                                
   Intestine Small, Duodenum                          (47)         (50)         (49)         (47)                                   
      Artery, Inflammation, Chronic                                              1 (2%)                                             
      Muscularis, Necrosis, Focal                                                             1 (2%)                                
   Intestine Small, Jejunum                           (47)         (41)         (47)         (42)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Intestine Small, Ileum                             (44)         (40)         (40)         (41)                                   
      Inflammation, Chronic                                         1 (3%)                                                          
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis, Focal                               7 (14%)      1 (2%)       1 (2%)       1 (2%)                                
      Basophilic Focus                                17 (34%)     18 (36%)      9 (18%)     21 (42%)                               
      Clear Cell Focus                                 2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Degeneration, Cystic, Focal                      4 (8%)       1 (2%)       6 (12%)      5 (10%)                               
      Eosinophilic Focus                               8 (16%)     10 (20%)      7 (14%)     14 (28%)                               
      Hematopoietic Cell Proliferation                 2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Hepatodiaphragmatic Nodule                       4 (8%)                    1 (2%)       2 (4%)                                
      Mixed Cell Focus                                 4 (8%)       8 (16%)      8 (16%)                                            
      Necrosis                                         1 (2%)                    5 (10%)      3 (6%)                                
      Bile Duct, Hyperplasia                          10 (20%)      1 (2%)       2 (4%)       4 (8%)                                
      Centrilobular, Necrosis                          2 (4%)       1 (2%)       1 (2%)       2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Vacuolization Cytoplasmic            3 (6%)      12 (24%)     13 (26%)     10 (20%)                               
      Vein, Thrombosis                                 2 (4%)       1 (2%)                                                          
   Mesentery                                          (20)         (7)          (3)          (3)                                    
      Metaplasia, Osseous                                                                     1 (33%)                               
      Polyarteritis                                                              1 (33%)                                            
      Artery, Inflammation, Chronic                                              1 (33%)                                            
      Fat, Necrosis                                   19 (95%)      4 (57%)      1 (33%)      2 (67%)                               
   Pancreas                                           (50)         (50)         (50)         (47)                                   
      Infiltration Cellular, Focal, Lymphocyte         1 (2%)                                                                       
      Necrosis, Diffuse                                                          1 (2%)                                             
      Pigmentation, Focal                                           1 (2%)                                                          
      Acinus, Atrophy, Diffuse                         1 (2%)       1 (2%)       1 (2%)                                             
      Acinus, Atrophy, Focal                          22 (44%)     18 (36%)     25 (50%)     31 (66%)                               
      Acinus, Hyperplasia, Focal                       1 (2%)       5 (10%)      4 (8%)       2 (4%)                                
      Artery, Inflammation, Chronic                                 3 (6%)                                                          
   Salivary Glands                                    (50)         (49)         (49)         (49)                                   
      Atrophy                                          1 (2%)                                                                       
      Duct, Sublingual Gland, Hyperplasia, Focal       1 (2%)                    1 (2%)                                             
      Parotid Gland, Atrophy                                                                  1 (2%)                                
      Parotid Gland, Atrophy, Focal                                              1 (2%)                                             
      Parotid Gland, Inflammation, Chronic Active                                             1 (2%)                                
      Sublingual Gland, Atrophy                                     2 (4%)                                                          
      Sublingual Gland, Inflammation, Chronic          1 (2%)                                                                       
      Submandibular Gland, Atrophy                                                            1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Edema                                            1 (2%)       3 (6%)       1 (2%)       4 (8%)                                
      Erosion, Focal                                                             1 (2%)       2 (4%)                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                                                      5 (10%)      2 (4%)                                
      Ulcer, Focal                                     2 (4%)       2 (4%)       4 (8%)       3 (6%)                                
      Epithelium, Hyperplasia                          4 (8%)       2 (4%)      12 (24%)      9 (18%)                               
      Muscularis, Mineralization                                    2 (4%)       2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
      Degeneration                                                 11 (22%)      5 (10%)      4 (8%)                                
      Edema                                                                      1 (2%)                                             
      Erosion, Focal                                   8 (16%)      6 (12%)      4 (8%)       6 (12%)                               
      Inflammation, Acute                              1 (2%)                                 1 (2%)                                
      Mineralization                                               11 (22%)      5 (10%)      5 (10%)                               
      Mineralization, Focal                                                                   1 (2%)                                
      Ulcer, Focal                                                  1 (2%)       1 (2%)                                             
      Glands, Cyst, Focal                                           1 (2%)       2 (4%)       3 (6%)                                
      Glands, Inflammation, Acute, Focal                                         1 (2%)                                             
      Muscularis, Mineralization                                                 2 (4%)                                             
   Tooth                                                                                     (1)                                    
      Necrosis                                                                                1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (49)         (50)         (50)                                   
      Aorta, Media, Mineralization                                  9 (18%)      3 (6%)       4 (8%)                                
   Heart                                              (50)         (49)         (50)         (50)                                   
      Cardiomyopathy                                  39 (78%)     36 (73%)     41 (82%)     38 (76%)                               
      Fibrosis                                                                                1 (2%)                                
      Artery, Mineralization                                        1 (2%)       2 (4%)                                             
      Atrium, Thrombosis                               3 (6%)       2 (4%)       2 (4%)                                             
      Atrium, Epicardium, Hyperplasia, Focal           1 (2%)                                                                       
      Atrium, Epicardium, Pigmentation                 1 (2%)                                                                       
      Myocardium, Inflammation, Acute                                            2 (4%)                                             
      Myocardium, Mineralization                                                 2 (4%)       1 (2%)                                
      Valve, Inflammation, Acute                                                 1 (2%)                                             
      Valve, Inflammation, Chronic Active                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Hematopoietic Cell Proliferation                              1 (2%)                    1 (2%)                                
      Hyperplasia, Focal                               4 (8%)       1 (2%)       1 (2%)       6 (12%)                               
      Hypertrophy, Focal                               2 (4%)                                                                       
      Inflammation                                                                            1 (2%)                                
      Necrosis                                                                   2 (4%)       1 (2%)                                
      Vacuolization Cytoplasmic, Focal                 6 (12%)     11 (22%)      4 (8%)       7 (14%)                               
      Bilateral, Hematopoietic Cell Proliferation                                             1 (2%)                                
      Bilateral, Necrosis                                           4 (8%)       3 (6%)       1 (2%)                                
      Bilateral, Vacuolization Cytoplasmic, Focal                   2 (4%)       2 (4%)       1 (2%)                                
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                              12 (24%)     21 (42%)     16 (32%)     19 (38%)                               
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Bilateral, Hyperplasia, Focal                    1 (2%)       1 (2%)       2 (4%)       4 (8%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (48)                                   
      Hyperplasia, Focal                               2 (4%)                                 2 (4%)                                
   Parathyroid Gland                                  (41)         (48)         (49)         (46)                                   
      Hyperplasia, Diffuse                                          6 (13%)      3 (6%)       8 (17%)                               
      Hyperplasia, Focal                               1 (2%)                                                                       
      Bilateral, Hyperplasia                                                                  1 (2%)                                
      Bilateral, Hyperplasia, Diffuse                              10 (21%)     11 (22%)      6 (13%)                               
   Pituitary Gland                                    (50)         (50)         (50)         (50)                                   
      Hyperplasia, Focal                                                                      1 (2%)                                
      Pars Distalis, Angiectasis, Focal                1 (2%)                    1 (2%)                                             
      Pars Distalis, Cyst                              1 (2%)       4 (8%)       5 (10%)      5 (10%)                               
      Pars Distalis, Hemorrhage, Focal                                                        1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                9 (18%)      6 (12%)      4 (8%)      11 (22%)                               
      Pars Distalis, Hypertrophy, Focal                1 (2%)                                                                       
      Pars Nervosa, Hyperplasia                        1 (2%)       1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Rathke's Cleft, Pigmentation                     1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (49)         (49)                                   
      Necrosis                                                      1 (2%)                                                          
      Ultimobranchial Cyst                                                       1 (2%)                                             
      C-Cell, Hyperplasia, Focal                      13 (26%)      3 (6%)       9 (18%)      4 (8%)                                
      Follicle, Cyst                                   3 (6%)       4 (8%)       7 (14%)      6 (12%)                               
      Follicular Cell, Hyperplasia                                                            1 (2%)                                
      Follicular Cell, Hyperplasia, Focal                           1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Mediastinum, Hemorrhage                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm, Focal                                                                  1 (2%)                                
      Inflammation, Chronic                                         2 (4%)       1 (2%)                                             
      Polyarteritis                                                              1 (2%)                                             
   Preputial Gland                                    (50)         (49)         (50)         (49)                                   
      Atrophy                                                                                 1 (2%)                                
      Cyst                                                          1 (2%)                                                          
      Hyperplasia, Focal                               3 (6%)       2 (4%)       2 (4%)                                             
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                           14 (28%)     14 (29%)      8 (16%)     13 (27%)                               
      Inflammation, Chronic Active                     1 (2%)       2 (4%)       4 (8%)       4 (8%)                                
      Bilateral, Inflammation, Chronic                21 (42%)     21 (43%)     25 (50%)     20 (41%)                               
      Bilateral, Inflammation, Chronic Active          6 (12%)      8 (16%)      9 (18%)      4 (8%)                                
      Duct, Hyperplasia                                                          1 (2%)                                             
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Atrophy                                         14 (28%)      8 (16%)      9 (18%)     13 (26%)                               
      Inflammation, Acute                              6 (12%)      5 (10%)      4 (8%)      10 (20%)                               
      Inflammation, Chronic                            1 (2%)       2 (4%)       1 (2%)       4 (8%)                                
      Inflammation, Chronic Active                     3 (6%)       7 (14%)      8 (16%)      5 (10%)                               
      Epithelium, Hyperplasia, Focal                   1 (2%)       2 (4%)       5 (10%)      3 (6%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)                                   
      Atrophy                                         33 (66%)     44 (88%)     45 (90%)     47 (94%)                               
      Inflammation, Acute                              1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Mineralization, Focal                            1 (2%)                                                                       
      Bilateral, Artery, Inflammation, Chronic                      1 (2%)                                                          
      Bilateral, Interstitial Cell, Hyperplasia,                                                                                    
           Focal                                       2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Bilateral, Germinal Epithelium, Atrophy          4 (8%)       3 (6%)                    2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Germinal Epithelium, Atrophy                     2 (4%)                    1 (2%)       2 (4%)                                
      Interstitial Cell, Hyperplasia, Focal            2 (4%)       2 (4%)       3 (6%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (48)         (50)         (50)         (49)                                   
      Atrophy                                          1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Fibrosis                                                                                1 (2%)                                
      Hemorrhage                                                                              2 (4%)                                
      Hyperplasia                                     15 (31%)     18 (36%)     21 (42%)     26 (53%)                               
      Myelofibrosis                                    1 (2%)                                                                       
      Necrosis                                         1 (2%)                    2 (4%)       1 (2%)                                
   Lymph Node                                         (17)         (22)         (27)         (20)                                   
      Infiltration Cellular, Histiocyte                                                       1 (5%)                                
      Iliac, Hyperplasia, Lymphoid                                               1 (4%)       1 (5%)                                
      Iliac, Infiltration Cellular, Histiocyte                                                1 (5%)                                
      Inguinal, Hyperplasia, Lymphoid                                            2 (7%)                                             
      Mediastinal, Hematopoietic Cell Proliferation                                           1 (5%)                                
      Mediastinal, Hemorrhage                          1 (6%)       1 (5%)       3 (11%)      1 (5%)                                
      Mediastinal, Hyperplasia, Lymphoid                            1 (5%)       4 (15%)      1 (5%)                                
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                             2 (7%)       1 (5%)                                
      Mediastinal, Pigmentation                        1 (6%)       1 (5%)       1 (4%)       2 (10%)                               
      Pancreatic, Fibrosis                                                                    1 (5%)                                
      Pancreatic, Hematopoietic Cell Proliferation                                            1 (5%)                                
      Pancreatic, Hemorrhage                           1 (6%)                    1 (4%)                                             
      Renal, Congestion                                                                       1 (5%)                                
      Renal, Hemorrhage                                2 (12%)      3 (14%)      5 (19%)      2 (10%)                               
      Renal, Hyperplasia, Lymphoid                                  2 (9%)       3 (11%)      2 (10%)                               
      Renal, Infiltration Cellular, Histiocyte                      1 (5%)       1 (4%)       2 (10%)                               
      Renal, Pigmentation                                           1 (5%)       1 (4%)       2 (10%)                               
   Lymph Node, Mandibular                             (50)         (49)         (49)         (49)                                   
      Degeneration, Cystic                             9 (18%)      6 (12%)      2 (4%)       5 (10%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            7 (14%)      6 (12%)     12 (24%)      7 (14%)                               
      Infiltration Cellular, Histiocyte                2 (4%)                    2 (4%)       4 (8%)                                
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
      Pigmentation                                     1 (2%)                                 1 (2%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (47)         (48)                                   
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Degeneration, Cystic                                                                    1 (2%)                                
      Degeneration, Cystic, Focal                                                             1 (2%)                                
      Ectasia                                                                                 1 (2%)                                
      Hemorrhage                                       4 (8%)       2 (4%)       2 (4%)       1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)       2 (4%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Infiltration Cellular, Histiocyte               33 (66%)     18 (36%)     22 (47%)     23 (48%)                               
      Inflammation, Chronic                                                      1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (49)                                   
      Congestion                                       1 (2%)                    6 (12%)      2 (4%)                                
      Fibrosis                                         3 (6%)       8 (16%)      6 (12%)      4 (8%)                                
      Hematopoietic Cell Proliferation                 6 (12%)      5 (10%)      5 (10%)      6 (12%)                               
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Pigmentation                                                  1 (2%)       4 (8%)       2 (4%)                                
      Capsule, Degeneration, Cystic                    1 (2%)                                                                       
      Lymphoid Follicle, Atrophy                       2 (4%)       8 (16%)      9 (18%)     12 (24%)                               
   Thymus                                             (50)         (49)         (47)         (47)                                   
      Angiectasis, Focal                                            1 (2%)                                                          
      Cyst                                                          1 (2%)                                                          
      Hemorrhage                                       3 (6%)                                                                       
      Necrosis, Diffuse                                                          1 (2%)                                             
      Epithelial Cell, Hyperplasia                    24 (48%)     25 (51%)     31 (66%)     22 (47%)                               
      Thymocyte, Atrophy                              33 (66%)     33 (67%)     37 (79%)     34 (72%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (43)         (47)         (48)         (47)                                   
      Galactocele                                      8 (19%)      9 (19%)     13 (27%)      8 (17%)                               
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Chronic                                                      1 (2%)                                             
      Mineralization, Focal                                                                   1 (2%)                                
      Pigmentation                                     1 (2%)       7 (15%)                   5 (11%)                               
      Epithelium, Hyperplasia                          1 (2%)                    2 (4%)       2 (4%)                                
   Skin                                               (49)         (50)         (50)         (50)                                   
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hyperkeratosis                                                                          1 (2%)                                
      Hyperplasia, Basal Cell                                                                 1 (2%)                                
      Ulcer                                                                                   1 (2%)                                
      Artery, Thrombosis                                                                      1 (2%)                                
      Epidermis, Hyperplasia                                                     1 (2%)                                             
      Lip, Inflammation, Chronic Active                             1 (2%)                                                          
      Lip, Ulcer                                                                              1 (2%)                                
      Subcutaneous Tissue, Inflammation, Acute                                                1 (2%)                                
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                              1 (2%)                                
      Vein, Inflammation, Acute                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   14                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Femur, Fibrous Osteodystrophy                                17 (34%)     14 (28%)     12 (24%)                               
      Femur, Hyperostosis                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Joint, Inflammation, Chronic                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hydrocephalus                                    1 (2%)       1 (2%)       1 (2%)                                             
      Cerebellum, Gliosis, Focal                                                              1 (2%)                                
      Cerebellum, Inflammation, Acute, Focal                                     1 (2%)                                             
      Cerebrum, Inflammation, Acute                                              1 (2%)                                             
      Cerebrum, Necrosis                                                         1 (2%)                                             
      Choroid Plexus, Cerebrum, Infiltration                                                                                        
          Cellular, Lymphocyte                                      1 (2%)                                                          
      Hippocampus, Cerebrum, Necrosis, Focal           1 (2%)                                                                       
      Meninges, Hemorrhage                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                       3 (6%)                    1 (2%)       2 (4%)                                
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       1 (2%)       3 (6%)       4 (8%)                                
      Infiltration Cellular, Focal, Histiocyte         2 (4%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Focal          2 (4%)       1 (2%)       2 (4%)                                             
      Artery, Mineralization                                        1 (2%)       1 (2%)                                             
      Interstitium, Inflammation, Acute                                          1 (2%)                                             
      Interstitium, Inflammation, Chronic              3 (6%)       8 (16%)      7 (14%)      6 (12%)                               
      Interstitium, Inflammation, Chronic Active                    1 (2%)       1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Inflammation, Acute                              1 (2%)                                 1 (2%)                                
      Inflammation, Chronic                            2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Chronic Active                    14 (28%)     12 (24%)     15 (30%)     16 (32%)                               
      Metaplasia, Focal, Squamous                                                1 (2%)       2 (4%)                                
      Metaplasia, Squamous                             1 (2%)       1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Acute                                     1 (2%)       1 (2%)                                
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)                                 1 (2%)                                
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Glands, Cyst, Focal                              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   15                                                              
NTP Experiment-Test: 05182-03         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          PHENOLPHTHALEIN                                      Date: 04/04/96  
Route: DOSED FEED                                                                                                 Time: 03:10:02  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 PPM        12000        25000        50000                                     
                                                                PPM          PPM          PPM                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)                       (2)                                    
      Cornea, Inflammation, Chronic                                 1 (100%)                  1 (50%)                               
      Cornea, Inflammation, Chronic Active                                                    1 (50%)                               
      Retina, Atrophy                                               1 (100%)                  1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)       3 (6%)       8 (16%)     10 (20%)                               
      Hydronephrosis                                                1 (2%)                                                          
      Inflammation, Acute                                                        1 (2%)                                             
      Mineralization, Focal                            1 (2%)                                                                       
      Nephropathy, Chronic                             2 (4%)       1 (2%)       1 (2%)                                             
      Bilateral, Cyst                                              16 (32%)     13 (26%)     12 (24%)                               
      Bilateral, Inflammation, Acute                                             1 (2%)                                             
      Bilateral, Mineralization, Focal                              2 (4%)       1 (2%)       1 (2%)                                
      Bilateral, Nephropathy, Chronic                 45 (90%)     48 (96%)     49 (98%)     50 (100%)                              
      Bilateral, Pelvis, Transitional Epithelium,                                                                                   
           Hyperplasia                                 1 (2%)      21 (42%)     20 (40%)     17 (34%)                               
      Bilateral, Renal Tubule, Hyperplasia, Focal                   1 (2%)                                                          
      Bilateral, Renal Tubule, Pigmentation           10 (20%)      5 (10%)      7 (14%)      6 (12%)                               
      Pelvis, Inflammation, Acute                                                             1 (2%)                                
      Pelvis, Transitional Epithelium, Hyperplasia     3 (6%)      10 (20%)     14 (28%)     12 (24%)                               
      Renal Tubule, Hyperplasia, Focal                              5 (10%)      7 (14%)      2 (4%)                                
      Renal Tubule, Hyperplasia, Oncocytic                                                    1 (2%)                                
      Vein, Inflammation, Chronic                                                1 (2%)                                             
      Vein, Thrombosis                                                           1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Hemorrhage                                       2 (4%)                                                                       
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   16                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------