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TDMS Study 05187-06 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10     
LAB: Battelle Columbus                                       METHYLEUGENOL                                     DATE: 07/20/98       
EXPERIMENT: 05187 TEST: 06                                                                                     TIME: 10:26:20       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: NO1-ES-25337                              ROUTE: GAVAGE                                                  NTP C#: 60991B       
PATHOLOGIST: TOFT, J.                                                                                          CAS: 93-15-2         
------------------------------------------------------------------------------------------------------------------------------------
                                                                                                                                    
                                                             CORE STUDY                                                             
                                                                                                                                    

               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                                       METHYLEUGENOL                                     DATE: 07/20/98     
EXPERIMENT: 05187 TEST: 06                                                                                     TIME: 10:26:20     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25337                              ROUTE: GAVAGE                                                  NTP C#: 60991B     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 93-15-2       



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                  METHYLEUGENOL
===============================================================

Male Mice
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hypertrophy
Bone Marrow                            Hyperplasia
Islets, Pancreatic                     Hyperplasia
Kidney                                 Infiltration Cellular Lymphocyte
                                       Mineralization
                                       Nephropathy
Kidney: Cortex                         Cyst
Liver                                  Clear Cell Focus
                                       Eosinophilic Focus
                                       Inflammation Chronic
Liver: Hepatocyte                      Necrosis
Liver: Hepatocyte, Centrilobular       Necrosis
Liver: Oval Cell                       Hyperplasia
Liver: Portal                          Hypertrophy
Pancreas: Acinus                       Atrophy
Pituitary Gland: Pars Distalis         Cyst
Spleen: Red Pulp                       Hematopoietic Cell Proliferation
Stomach, Glandular                     Atrophy
                                       Ectasia
                                       Hyperplasia
                                       Inflammation Chronic
                                       Mineralization
Stomach, Glandular: Neuroendocrine Cell
                                       Hyperplasia
Thymus                                 Cyst
Thyroid Gland                          Inflammation Chronic
Urinary Bladder                        Infiltration Cellular Lymphocyte
===============================================================
Female Mice
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Hematopoietic Cell Proliferation
Adrenal Cortex: Subcapsular            Hyperplasia
Adrenal Medulla                        Hyperplasia
Bone Marrow                            Hyperplasia
                                       Myelofibrosis
Heart: Atrium                          Thrombosis
Islets, Pancreatic                     Hyperplasia
Kidney                                 Hydronephrosis
                                       Infiltration Cellular Lymphocyte
                                       Nephropathy
Kidney: Cortex                         Cyst
Kidney: Renal Tubule                   Pigmentation Hemosiderin
Liver                                  Basophilic Focus
                                       Eosinophilic Focus
                                       Hematopoietic Cell Proliferation
                                       Infiltration Cellular Lymphocyte
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Columbus                                       METHYLEUGENOL                                     DATE: 07/20/98     
EXPERIMENT: 05187 TEST: 06                                                                                     TIME: 10:26:20     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                      
CONT: NO1-ES-25337                              ROUTE: GAVAGE                                                  NTP C#: 60991B     
PATHOLOGIST: TOFT, J.                                                                                          CAS: 93-15-2       

                                       Inflammation Chronic
                                       Mixed Cell Focus
                                       Pigmentation Hemosiderin
Liver: Bile Duct                       Cyst
                                       Hyperplasia
Liver: Hepatocyte                      Necrosis
                                       Vacuolization Cytoplasmic
Liver: Oval Cell                       Hyperplasia
Liver: Portal                          Hypertrophy
Lung: Alveolus                         Infiltration Cellular Histiocyte
Nose                                   Inflammation
Nose: Nasolacrimal Duct                Inflammation
Ovary                                  Thrombosis
Pancreas                               Infiltration Cellular Lymphocyte
Pituitary Gland: Pars Distalis         Angiectasis
Salivary Glands                        Infiltration Cellular Lymphocyte
Skeletal Muscle                        Infiltration Cellular Lymphocyte
Skin: Subcutaneous Tissue              Infiltration Cellular Lymphocyte
Spleen: Lymphoid Follicle              Hyperplasia Lymphoid
                                       Necrosis
Spleen: Red Pulp                       Hematopoietic Cell Proliferation
Stomach, Glandular                     Atrophy
                                       Ectasia
                                       Hyperplasia
                                       Inflammation Chronic
Thymus                                 Cyst
Thyroid Gland: Follicular Cell         Hyperplasia
Urinary Bladder                        Infiltration Cellular Lymphocyte
Uterus                                 Hydrometra
                                       Hyperplasia Cystic
===============================================================
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Accessory Adrenal Cortical Nodule                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    2/36 (6%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.415N     P=0.226      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.398N     P=0.249      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.398N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.400N     P=0.250      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.226      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.398N     P=0.253      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    8/50 (16%)   17/50 (34%)  14/49 (29%)  |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         19.2%        41.7%        35.6%        |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |2/31 (7%)    1/18 (6%)    8/18 (44%)   0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      519          619          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.019 *    P<0.001 **   P<0.001 **   |
|POLY 3             |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.033 *    P<0.001 **   P<0.001 **   |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.039 *    P<0.001 **   P<0.001 **   |
|POLY 6             |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.027 *    P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.002 **   P=0.066      P<0.001 **   P=0.004 **   |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.046 *    P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    5/50 (10%)   3/50 (6%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         10.9%        6.9%         4.6%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    5/36 (14%)   2/37 (5%)    2/35 (6%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      691          730 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.427      P=0.029 *    P=0.120      P=0.220     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.449      P=0.035 *    P=0.119      P=0.236     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.456      P=0.034 *    P=0.119      P=0.238     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.441      P=0.035 *    P=0.119      P=0.234     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.438      P=0.029 *    P=0.120      P=0.220     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.467      P=0.030 *    P=0.125      P=0.253     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex: Subcapsular                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     38/49 (78%)  42/50 (84%)  44/50 (88%)  43/50 (86%) |47/50 (94%)  48/50 (96%)  49/50 (98%)  48/49 (98%)  |
|POLY-3 ADJUSTED (b)|     79.3%        86.3%        90.8%        88.6%       |95.6%        97.2%        99.7%        98.9%        |
|TERMINAL (d)       |     29/38 (76%)  32/36 (89%)  33/37 (89%)  30/35 (86%) |31/31 (100%) 18/18 (100%) 18/18 (100%) 2/2 (100%)   |
|FIRST INCIDENCE    |     430          488          326          459         |178          477          465          379          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.109      P=0.229      P=0.148      P=0.130     |P<0.001 **   P=0.002 **   P=0.002 **   P<0.001 **   |
|POLY 3             |     P=0.123      P=0.257      P=0.093      P=0.161     |P=0.149      P=0.551      P=0.205      P=0.323      |
|POLY 1.5           |     P=0.127      P=0.274      P=0.089      P=0.167     |P=0.165      P=0.523      P=0.216      P=0.312      |
|POLY 6             |     P=0.135      P=0.225      P=0.100      P=0.167     |P=0.147      P=0.627      P=0.272      P=0.383      |
|LOGISTIC REGRESSION|     P=0.143      P=0.303      P=0.111      P=0.195     |P=0.143      P=0.462      P=0.253      P=0.255      |
|COCH-ARM / FISHERS |     P=0.171      P=0.288      P=0.133      P=0.204     |P=0.204      P=0.500      P=0.309      P=0.316      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    7/50 (14%)   5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         2.6%         17.5%        14.6%        |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    1/18 (6%)    4/18 (22%)   1/2 (50%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          731 (T)      659          676          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.392      P<0.001 **   P<0.001 **   |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.003 **   P=0.471      P=0.004 **   P=0.014 *    |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.006 **   P=0.485      P=0.006 **   P=0.020 *    |
|POLY 6             |     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.450      P=0.003 **   P=0.008 **   |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P<0.001 **   P=0.392      P=0.005 **   P=0.003 **   |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.013 *    P=0.500      P=0.006 **   P=0.027 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     14/49 (29%)  26/49 (53%)  33/50 (66%)  35/50 (70%) |18/50 (36%)  47/50 (94%)  46/48 (96%)  50/50 (100%) |
|POLY-3 ADJUSTED (b)|     29.9%        54.7%        71.2%        74.7%       |37.5%        96.0%        97.1%        100.0%       |
|TERMINAL (d)       |     8/38 (21%)   18/36 (50%)  27/37 (73%)  25/35 (71%) |4/31 (13%)   17/18 (94%)  18/18 (100%) 2/2 (100%)   |
|FIRST INCIDENCE    |     477          488          326          512         |564          477          465          379          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.023 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.011 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Myelofibrosis                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |10/50 (20%)  6/50 (12%)   3/48 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |22.2%        15.6%        7.7%         8.4%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |9/31 (29%)   5/18 (28%)   2/18 (11%)   0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |630          720          637          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.533      P=0.609      P=0.183N     P=0.411      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.033N*    P=0.311N     P=0.060N     P=0.083N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.025N*    P=0.257N     P=0.050N     P=0.055N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.050N     P=0.401N     P=0.076N     P=0.149N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.079N     P=0.522N     P=0.087N     P=0.076N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.020N*    P=0.207N     P=0.042N*    P=0.036N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/47 (0%)    2/47 (4%)    0/46 (0%)    0/44 (0%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         5.5%         0.0%         0.0%         |
|TERMINAL (d)       |                                                        |0/30 (0%)    0/17 (0%)    0/17 (0%)    0/0 (0%)     |
|FIRST INCIDENCE    |                                                        |---          604          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.449N     P=0.202      (e)          (e)          |
|POLY 3             |                                                        |P=0.480N     P=0.207      (e)          (e)          |
|POLY 1.5           |                                                        |P=0.448N     P=0.221      (e)          (e)          |
|POLY 6             |                                                        |P=0.526N     P=0.188      (e)          (e)          |
|LOGISTIC REGRESSION|                                                        |P=0.389N     P=0.252      (e)          (e)          |
|COCH-ARM / FISHERS |                                                        |P=0.415N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Epididymis                                                                                                                       |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     2.3%         2.2%         0.0%         4.6%        |                                                    |
|TERMINAL (d)       |     1/38 (3%)    1/36 (3%)    0/37 (0%)    2/35 (6%)   |                                                    |
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          730 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.347      P=0.750      P=0.505N     P=0.471     |                                                    |
|POLY 3             |     P=0.362      P=0.749N     P=0.500N     P=0.499     |                                                    |
|POLY 1.5           |     P=0.365      P=0.751N     P=0.500N     P=0.502     |                                                    |
|POLY 6             |     P=0.359      P=0.748N     P=0.500N     P=0.495     |                                                    |
|LOGISTIC REGRESSION|     P=0.347      P=0.750      (e)          P=0.471     |                                                    |
|COCH-ARM / FISHERS |     P=0.371      P=0.747N     P=0.495N     P=0.508     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/48 (0%)    0/44 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    1/36 (3%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      ---          459         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.135      P=0.489      (e)          P=0.240     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.142      P=0.511      (e)          P=0.243     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.142      P=0.509      (e)          P=0.242     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.142      P=0.511      (e)          P=0.243     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.156      P=0.489      (e)          P=0.304     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.142      P=0.505      (e)          P=0.253     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    1/48 (2%)    0/44 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         0.0%         2.3%        |4.5%         2.6%         2.6%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          546          ---          561         |663          664          582          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.405      P=0.517      (e)          P=0.504     |P=0.281N     P=0.667N     P=0.614N     P=0.540N     |
|POLY 3             |     P=0.407      P=0.513      (e)          P=0.502     |P=0.206N     P=0.551N     P=0.557N     P=0.330N     |
|POLY 1.5           |     P=0.408      P=0.510      (e)          P=0.503     |P=0.190N     P=0.526N     P=0.538N     P=0.298N     |
|POLY 6             |     P=0.406      P=0.515      (e)          P=0.501     |P=0.233N     P=0.586N     P=0.582N     P=0.382N     |
|LOGISTIC REGRESSION|     P=0.446      P=0.340      (e)          P=0.555     |P=0.161N     P=0.513N     P=0.491N     P=0.322N     |
|COCH-ARM / FISHERS |     P=0.410      P=0.505      (e)          P=0.505     |P=0.174N     P=0.500N     P=0.515N     P=0.280N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    3/50 (6%)    6/48 (13%)   9/44 (20%)   |
|POLY-3 ADJUSTED (b)|     2.3%         2.2%         0.0%         4.6%        |2.2%         7.7%         15.5%        27.7%        |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    1/35 (3%)   |0/31 (0%)    0/18 (0%)    2/18 (11%)   1/2 (50%)    |
|FIRST INCIDENCE    |     670          670          ---          579         |663          627          582          577          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.351      P=0.746N     P=0.505N     P=0.488     |P<0.001 **   P=0.183      P=0.020 *    P<0.001 **   |
|POLY 3             |     P=0.363      P=0.749N     P=0.501N     P=0.501     |P<0.001 **   P=0.258      P=0.035 *    P<0.001 **   |
|POLY 1.5           |     P=0.366      P=0.751N     P=0.501N     P=0.503     |P<0.001 **   P=0.280      P=0.041 *    P=0.002 **   |
|POLY 6             |     P=0.361      P=0.748N     P=0.502N     P=0.498     |P<0.001 **   P=0.227      P=0.028 *    P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.383      P=0.748      P=0.491N     P=0.520     |P<0.001 **   P=0.314      P=0.050      P=0.003 **   |
|COCH-ARM / FISHERS |     P=0.371      P=0.747N     P=0.495N     P=0.508     |P<0.001 **   P=0.309      P=0.050      P=0.004 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     32/49 (65%)  26/49 (53%)  18/50 (36%)  17/50 (34%) |8/49 (16%)   3/50 (6%)    1/46 (2%)    2/47 (4%)    |
|POLY-3 ADJUSTED (b)|     68.1%        53.1%        37.1%        35.7%       |18.0%        7.5%         2.7%         6.0%         |
|TERMINAL (d)       |     25/38 (66%)  13/36 (36%)  7/37 (19%)   6/35 (17%)  |7/31 (23%)   0/18 (0%)    1/18 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     430          488          326          459         |670          582          731 (T)      652          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.011N*    P=0.222N     P=0.018N*    P=0.018N*   |P=0.274N     P=0.292N     P=0.085N     P=0.525      |
|POLY 3             |     P<0.001N**   P=0.095N     P=0.002N**   P<0.001N**  |P=0.037N*    P=0.134N     P=0.030N*    P=0.114N     |
|POLY 1.5           |     P<0.001N**   P=0.115N     P=0.002N**   P<0.001N**  |P=0.032N*    P=0.112N     P=0.025N*    P=0.080N     |
|POLY 6             |     P<0.001N**   P=0.077N     P<0.001N**   P<0.001N**  |P=0.047N*    P=0.170N     P=0.040N*    P=0.187N     |
|LOGISTIC REGRESSION|     P<0.001N**   P=0.184N     P=0.002N**   P<0.001N**  |P=0.043N*    P=0.104N     P=0.053N     P=0.247N     |
|COCH-ARM / FISHERS |     P<0.001N**   P=0.152N     P=0.003N**   P=0.002N**  |P=0.030N*    P=0.094N     P=0.019N*    P=0.053N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Accumulation, Hyaline Droplet                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.2%         7.6%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |695          578          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.281N     P=0.215      P=0.570N     P=0.759N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.204N     P=0.261      P=0.526N     P=0.556N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.178N     P=0.282      P=0.514N     P=0.531N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.248N     P=0.232      P=0.542N     P=0.594N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.136N     P=0.332      P=0.517N     P=0.585N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.154N     P=0.309      P=0.500N     P=0.505N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Hydronephrosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         5.8%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          ---          ---          592          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.040 *    (e)          (e)          P=0.202      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.037 *    (e)          (e)          P=0.185      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.040 *    (e)          (e)          P=0.207      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.034 *    (e)          (e)          P=0.155      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.058      (e)          (e)          P=0.279      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.045 *    (e)          (e)          P=0.242      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     29/49 (59%)  32/50 (64%)  27/50 (54%)  40/50 (80%) |28/50 (56%)  29/50 (58%)  29/50 (58%)  23/49 (47%)  |
|POLY-3 ADJUSTED (b)|     64.2%        67.4%        60.1%        85.7%       |59.8%        65.7%        64.1%        56.3%        |
|TERMINAL (d)       |     25/38 (66%)  27/36 (75%)  23/37 (62%)  31/35 (89%) |21/31 (68%)  14/18 (78%)  12/18 (67%)  0/2 (0%)     |
|FIRST INCIDENCE    |     537          546          486          459         |178          477          465          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.008 **   P=0.270      P=0.471N     P=0.008 **  |P<0.001 **   P=0.013 *    P=0.022 *    P<0.001 **   |
|POLY 3             |     P=0.012 *    P=0.458      P=0.425N     P=0.011 *   |P=0.361N     P=0.351      P=0.415      P=0.452N     |
|POLY 1.5           |     P=0.014 *    P=0.435      P=0.424N     P=0.013 *   |P=0.275N     P=0.417      P=0.444      P=0.355N     |
|POLY 6             |     P=0.011 *    P=0.463      P=0.430N     P=0.010 *   |P=0.496N     P=0.266      P=0.394      P=0.593      |
|LOGISTIC REGRESSION|     P=0.010 *    P=0.479      P=0.418N     P=0.011 *   |P=0.252N     P=0.418      P=0.467      P=0.313N     |
|COCH-ARM / FISHERS |     P=0.023 *    P=0.387      P=0.376N     P=0.021 *   |P=0.179N     P=0.500      P=0.500      P=0.242N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Metaplasia Osseous                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    3/50 (6%)    0/50 (0%)    1/50 (2%)   |2/50 (4%)    1/50 (2%)    0/50 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     2.3%         6.5%         0.0%         2.3%        |4.5%         2.6%         0.0%         3.0%         |
|TERMINAL (d)       |     1/38 (3%)    2/36 (6%)    0/37 (0%)    1/35 (3%)   |2/31 (7%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     730 (T)      655          ---          730 (T)     |731 (T)      658          ---          717          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.427N     P=0.301      P=0.505N     P=0.743     |P=0.574      P=0.668N     P=0.364N     P=0.339      |
|POLY 3             |     P=0.407N     P=0.327      P=0.500N     P=0.760     |P=0.386N     P=0.549N     P=0.267N     P=0.596N     |
|POLY 1.5           |     P=0.405N     P=0.322      P=0.500N     P=0.759N    |P=0.380N     P=0.525N     P=0.253N     P=0.554N     |
|POLY 6             |     P=0.409N     P=0.329      P=0.500N     P=0.758     |P=0.392N     P=0.582N     P=0.286N     P=0.660N     |
|LOGISTIC REGRESSION|     P=0.414N     P=0.322      (e)          P=0.743     |P=0.539N     P=0.580N     (e)          P=0.544      |
|COCH-ARM / FISHERS |     P=0.401N     P=0.316      P=0.495N     P=0.747N    |P=0.372N     P=0.500N     P=0.247N     P=0.508N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    3/50 (6%)    4/50 (8%)   |1/50 (2%)    3/50 (6%)    2/50 (4%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         6.8%         9.0%        |2.2%         7.7%         5.0%         5.8%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    2/37 (5%)    2/35 (6%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          694          572          561         |728          629          582          592          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.023 *    P=0.510      P=0.123      P=0.062     |P=0.208      P=0.171      P=0.377      P=0.233      |
|POLY 3             |     P=0.025 *    P=0.511      P=0.120      P=0.063     |P=0.370      P=0.260      P=0.459      P=0.411      |
|POLY 1.5           |     P=0.025 *    P=0.509      P=0.119      P=0.063     |P=0.428      P=0.281      P=0.478      P=0.450      |
|POLY 6             |     P=0.025 *    P=0.512      P=0.121      P=0.063     |P=0.284      P=0.231      P=0.435      P=0.352      |
|LOGISTIC REGRESSION|     P=0.029 *    P=0.501      P=0.125      P=0.071     |P=0.510      P=0.290      P=0.501      P=0.527      |
|COCH-ARM / FISHERS |     P=0.026 *    P=0.505      P=0.125      P=0.061     |P=0.492      P=0.309      P=0.500      P=0.492      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     43/49 (88%)  45/50 (90%)  45/50 (90%)  48/50 (96%) |10/50 (20%)  13/50 (26%)  9/50 (18%)   10/49 (20%)  |
|POLY-3 ADJUSTED (b)|     92.6%        92.4%        95.1%        97.7%       |22.3%        31.7%        22.2%        27.6%        |
|TERMINAL (d)       |     38/38 (100%) 35/36 (97%)  36/37 (97%)  35/35 (100%)|9/31 (29%)   6/18 (33%)   5/18 (28%)   2/2 (100%)   |
|FIRST INCIDENCE    |     430          488          326          339         |665          477          465          518          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.048 *    P=0.270      P=0.306      P=0.049 *   |P=0.002 **   P=0.044 *    P=0.261      P<0.001 **   |
|POLY 3             |     P=0.108      P=0.659N     P=0.463      P=0.196     |P=0.438      P=0.227      P=0.600N     P=0.384      |
|POLY 1.5           |     P=0.094      P=0.593      P=0.411      P=0.154     |P=0.537      P=0.272      P=0.553N     P=0.478      |
|POLY 6             |     P=0.154      P=0.587N     P=0.593      P=0.317     |P=0.291      P=0.168      P=0.546      P=0.251      |
|LOGISTIC REGRESSION|     P=0.042 *    P=0.585N     P=0.336      P=0.082     |P=0.458      P=0.216      P=0.553      P=0.292      |
|COCH-ARM / FISHERS |     P=0.100      P=0.486      P=0.486      P=0.128     |P=0.450N     P=0.318      P=0.500N     P=0.579      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Artery                                                                                                                   |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         0.0%         0.0%        |0.0%         5.1%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    1/36 (3%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      ---          ---         |---          632          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.575N     P=0.489      (e)          (e)         |P=0.616N     P=0.152      (e)          (e)          |
|POLY 3             |     P=0.561N     P=0.511      (e)          (e)         |P=0.472N     P=0.207      (e)          (e)          |
|POLY 1.5           |     P=0.562N     P=0.509      (e)          (e)         |P=0.440N     P=0.222      (e)          (e)          |
|POLY 6             |     P=0.561N     P=0.511      (e)          (e)         |P=0.517N     P=0.188      (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          P=0.489      (e)          (e)         |P=0.434N     P=0.229      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.562N     P=0.505      (e)          (e)         |P=0.405N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Cortex                                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/49 (20%)  27/50 (54%)  20/50 (40%)  14/50 (28%) |0/50 (0%)    1/50 (2%)    0/50 (0%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     22.7%        56.5%        45.6%        31.1%       |0.0%         2.6%         0.0%         5.9%         |
|TERMINAL (d)       |     8/38 (21%)   23/36 (64%)  19/37 (51%)  11/35 (31%) |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     540          488          575          339         |---          721          ---          676          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.497      P<0.001 **   P=0.019 *    P=0.193     |P=0.026 *    P=0.406      (e)          P=0.076      |
|POLY 3             |     P=0.484N     P<0.001 **   P=0.018 *    P=0.253     |P=0.105      P=0.471      (e)          P=0.182      |
|POLY 1.5           |     P=0.473N     P<0.001 **   P=0.019 *    P=0.257     |P=0.119      P=0.485      (e)          P=0.205      |
|POLY 6             |     P=0.501N     P<0.001 **   P=0.016 *    P=0.246     |P=0.087      P=0.450      (e)          P=0.150      |
|LOGISTIC REGRESSION|     P=0.504N     P<0.001 **   P=0.022 *    P=0.254     |P=0.066      P=0.424      (e)          P=0.135      |
|COCH-ARM / FISHERS |     P=0.460N     P<0.001 **   P=0.028 *    P=0.259     |P=0.137      P=0.500      (e)          P=0.242      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    2/50 (4%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         2.3%        |0.0%         0.0%         5.1%         5.9%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    1/18 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          554         |---          ---          704          652          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.198      (e)          (e)          P=0.504     |P=0.006 **   (e)          P=0.150      P=0.066      |
|POLY 3             |     P=0.197      (e)          (e)          P=0.502     |P=0.052      (e)          P=0.210      P=0.182      |
|POLY 1.5           |     P=0.198      (e)          (e)          P=0.503     |P=0.065      (e)          P=0.222      P=0.205      |
|POLY 6             |     P=0.196      (e)          (e)          P=0.501     |P=0.036 *    (e)          P=0.195      P=0.151      |
|LOGISTIC REGRESSION|     P=0.205      (e)          (e)          P=0.559     |P=0.033 *    (e)          P=0.179      P=0.167      |
|COCH-ARM / FISHERS |     P=0.199      (e)          (e)          P=0.505     |P=0.082      (e)          P=0.247      P=0.242      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   3/50 (6%)    1/50 (2%)    3/50 (6%)   |5/50 (10%)   2/50 (4%)    0/49 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     11.2%        6.5%         2.3%         6.9%        |11.2%        5.1%         0.0%         8.6%         |
|TERMINAL (d)       |     3/38 (8%)    2/36 (6%)    1/37 (3%)    3/35 (9%)   |4/31 (13%)   0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     554          593          730 (T)      730 (T)     |717          596          ---          652          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.301N     P=0.354N     P=0.110N     P=0.391N    |P=0.320      P=0.430N     P=0.096N     P=0.086      |
|POLY 3             |     P=0.285N     P=0.335N     P=0.107N     P=0.371N    |P=0.316N     P=0.274N     P=0.043N*    P=0.496N     |
|POLY 1.5           |     P=0.279N     P=0.338N     P=0.105N     P=0.361N    |P=0.305N     P=0.245N     P=0.038N*    P=0.428N     |
|POLY 6             |     P=0.292N     P=0.337N     P=0.110N     P=0.384N    |P=0.332N     P=0.320N     P=0.052N     P=0.605N     |
|LOGISTIC REGRESSION|     P=0.266N     P=0.393N     P=0.094N     P=0.345N    |P=0.483N     P=0.317N     P=0.072N     P=0.508      |
|COCH-ARM / FISHERS |     P=0.266N     P=0.346N     P=0.098N     P=0.346N    |P=0.294N     P=0.218N     P=0.030N*    P=0.357N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     16/49 (33%)  8/50 (16%)   2/50 (4%)    6/50 (12%)  |1/50 (2%)    2/50 (4%)    0/49 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     36.9%        17.0%        4.6%         13.8%       |2.2%         5.1%         0.0%         2.9%         |
|TERMINAL (d)       |     16/38 (42%)  6/36 (17%)   2/37 (5%)    5/35 (14%)  |1/31 (3%)    1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     730 (T)      488          730 (T)      705         |731 (T)      519          ---          634          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.009N**   P=0.061N     P<0.001N**   P=0.022N*   |P=0.514      P=0.371      P=0.608N     P=0.475      |
|POLY 3             |     P=0.006N**   P=0.027N*    P<0.001N**   P=0.011N*   |P=0.545N     P=0.454      P=0.526N     P=0.702      |
|POLY 1.5           |     P=0.005N**   P=0.032N*    P<0.001N**   P=0.011N*   |P=0.523N     P=0.477      P=0.516N     P=0.731      |
|POLY 6             |     P=0.006N**   P=0.023N*    P<0.001N**   P=0.011N*   |P=0.574N     P=0.421      P=0.541N     P=0.652      |
|LOGISTIC REGRESSION|     P=0.007N**   P=0.035N*    P<0.001N**   P=0.015N*   |P=0.474N     P=0.522      (e)          P=0.746      |
|COCH-ARM / FISHERS |     P=0.006N**   P=0.044N*    P<0.001N**   P=0.012N*   |P=0.499N     P=0.500      P=0.505N     P=0.753N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/49 (20%)  20/50 (40%)  25/50 (50%)  19/50 (38%) |5/50 (10%)   9/50 (18%)   4/49 (8%)    9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     23.0%        43.2%        55.3%        42.1%       |11.1%        22.6%        9.9%         23.7%        |
|TERMINAL (d)       |     10/38 (26%)  19/36 (53%)  21/37 (57%)  15/35 (43%) |4/31 (13%)   6/18 (33%)   1/18 (6%)    1/2 (50%)    |
|FIRST INCIDENCE    |     730 (T)      593          486          459         |652          493          590          379          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.034 *    P=0.013 *    P<0.001 **   P=0.023 *   |P=0.004 **   P=0.034 *    P=0.538      P=0.002 **   |
|POLY 3             |     P=0.065      P=0.033 *    P<0.001 **   P=0.043 *   |P=0.157      P=0.129      P=0.568N     P=0.108      |
|POLY 1.5           |     P=0.064      P=0.031 *    P<0.001 **   P=0.042 *   |P=0.202      P=0.159      P=0.541N     P=0.146      |
|POLY 6             |     P=0.068      P=0.033 *    P<0.001 **   P=0.044 *   |P=0.098      P=0.092      P=0.604N     P=0.061      |
|LOGISTIC REGRESSION|     P=0.049 *    P=0.029 *    P<0.001 **   P=0.037 *   |P=0.289      P=0.125      P=0.515N     P=0.266      |
|COCH-ARM / FISHERS |     P=0.071      P=0.028 *    P=0.002 **   P=0.044 *   |P=0.254      P=0.194      P=0.513N     P=0.194      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    4/50 (8%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    3/49 (6%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         8.7%         2.3%         0.0%        |2.2%         5.1%         7.5%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    3/36 (8%)    1/37 (3%)    0/35 (0%)   |0/31 (0%)    1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     430          614          730 (T)      ---         |632          633          521          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.175N     P=0.182      P=0.753      P=0.504N    |P=0.562N     P=0.367      P=0.233      P=0.581N     |
|POLY 3             |     P=0.167N     P=0.192      P=0.756      P=0.504N    |P=0.464N     P=0.449      P=0.265      P=0.552N     |
|POLY 1.5           |     P=0.163N     P=0.190      P=0.757      P=0.501N    |P=0.401N     P=0.474      P=0.281      P=0.527N     |
|POLY 6             |     P=0.171N     P=0.193      P=0.755      P=0.507N    |P=0.570N     P=0.414      P=0.244      P=0.591N     |
|LOGISTIC REGRESSION|     P=0.145N     P=0.122      P=0.713N     P=0.313N    |P=0.296N     P=0.518      P=0.320      P=0.468N     |
|COCH-ARM / FISHERS |     P=0.157N     P=0.187      P=0.747N     P=0.495N    |P=0.338N     P=0.500      P=0.301      P=0.500N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    9/50 (18%)   7/50 (14%)   9/50 (18%)  |4/50 (8%)    14/50 (28%)  23/49 (47%)  24/50 (48%)  |
|POLY-3 ADJUSTED (b)|     6.8%         19.7%        15.6%        20.0%       |8.9%         34.1%        53.2%        58.8%        |
|TERMINAL (d)       |     1/38 (3%)    9/36 (25%)   5/37 (14%)   5/35 (14%)  |2/31 (7%)    4/18 (22%)   10/18 (56%)  2/2 (100%)   |
|FIRST INCIDENCE    |     570          730 (T)      326          459         |673          582          484          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.093      P=0.057      P=0.163      P=0.061     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.107      P=0.066      P=0.160      P=0.062     |P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.109      P=0.067      P=0.160      P=0.063     |P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.105      P=0.063      P=0.159      P=0.060     |P<0.001 **   P=0.002 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.122      P=0.070      P=0.194      P=0.073     |P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.115      P=0.065      P=0.167      P=0.065     |P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/49 (12%)   5/50 (10%)   12/50 (24%)  10/50 (20%) |23/50 (46%)  18/50 (36%)  21/49 (43%)  19/50 (38%)  |
|POLY-3 ADJUSTED (b)|     13.8%        10.7%        27.2%        22.9%       |50.3%        44.6%        48.5%        47.9%        |
|TERMINAL (d)       |     6/38 (16%)   3/36 (8%)    11/37 (30%)  8/35 (23%)  |19/31 (61%)  14/18 (78%)  10/18 (56%)  1/2 (50%)    |
|FIRST INCIDENCE    |     730 (T)      546          486          604         |632          477          465          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.070      P=0.522N     P=0.084      P=0.163     |P<0.001 **   P=0.178      P=0.108      P<0.001 **   |
|POLY 3             |     P=0.080      P=0.451N     P=0.097      P=0.208     |P=0.498N     P=0.374N     P=0.518N     P=0.501N     |
|POLY 1.5           |     P=0.085      P=0.464N     P=0.096      P=0.211     |P=0.410N     P=0.280N     P=0.479N     P=0.381N     |
|POLY 6             |     P=0.075      P=0.443N     P=0.098      P=0.203     |P=0.435      P=0.541N     P=0.577N     P=0.496      |
|LOGISTIC REGRESSION|     P=0.083      P=0.468N     P=0.093      P=0.192     |P=0.457      P=0.580      P=0.546N     P=0.541      |
|COCH-ARM / FISHERS |     P=0.099      P=0.486N     P=0.104      P=0.220     |P=0.327N     P=0.208N     P=0.455N     P=0.272N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     18/49 (37%)  21/50 (42%)  28/50 (56%)  28/50 (56%) |24/50 (48%)  25/50 (50%)  16/49 (33%)  10/50 (20%)  |
|POLY-3 ADJUSTED (b)|     38.6%        45.0%        62.3%        62.9%       |51.0%        58.3%        38.6%        25.9%        |
|TERMINAL (d)       |     13/38 (34%)  19/36 (53%)  24/37 (65%)  24/35 (69%) |18/31 (58%)  14/18 (78%)  8/18 (44%)   1/2 (50%)    |
|FIRST INCIDENCE    |     430          488          572          569         |178          477          521          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.009 **   P=0.295      P=0.037 *    P=0.022 *   |P=0.210      P=0.020 *    P=0.533      P=0.115      |
|POLY 3             |     P=0.005 **   P=0.338      P=0.017 *    P=0.014 *   |P=0.003N**   P=0.308      P=0.165N     P=0.013N*    |
|POLY 1.5           |     P=0.009 **   P=0.354      P=0.021 *    P=0.021 *   |P<0.001N**   P=0.393      P=0.127N     P=0.006N**   |
|POLY 6             |     P=0.003 **   P=0.309      P=0.015 *    P=0.010 *   |P=0.011N*    P=0.201      P=0.224N     P=0.040N*    |
|LOGISTIC REGRESSION|     P=0.014 *    P=0.352      P=0.037 *    P=0.038 *   |P<0.001N**   P=0.444      P=0.106N     P<0.001N**   |
|COCH-ARM / FISHERS |     P=0.022 *    P=0.371      P=0.042 *    P=0.042 *   |P<0.001N**   P=0.500      P=0.088N     P=0.003N**   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    3/50 (6%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    2/50 (4%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         6.5%         2.3%         0.0%        |2.2%         5.1%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    2/36 (6%)    1/37 (3%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          655          730 (T)      ---         |632          658          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.380N     P=0.122      P=0.495      (e)         |P=0.264N     P=0.370      P=0.539N     P=0.581N     |
|POLY 3             |     P=0.364N     P=0.130      P=0.500      (e)         |P=0.226N     P=0.451      P=0.528N     P=0.552N     |
|POLY 1.5           |     P=0.362N     P=0.127      P=0.500      (e)         |P=0.207N     P=0.474      P=0.516N     P=0.527N     |
|POLY 6             |     P=0.367N     P=0.131      P=0.500      (e)         |P=0.256N     P=0.417      P=0.544N     P=0.591N     |
|LOGISTIC REGRESSION|     P=0.368N     P=0.126      P=0.495      (e)         |P=0.169N     P=0.527      P=0.493N     P=0.468N     |
|COCH-ARM / FISHERS |     P=0.358N     P=0.125      P=0.505      (e)         |P=0.188N     P=0.500      P=0.505N     P=0.500N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/49 (18%)   13/50 (26%)  9/50 (18%)   7/50 (14%)  |7/50 (14%)   3/50 (6%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     20.5%        27.5%        20.8%        16.1%       |15.6%        7.8%         0.0%         0.0%         |
|TERMINAL (d)       |     8/38 (21%)   10/36 (28%)  9/37 (24%)   6/35 (17%)  |5/31 (16%)   2/18 (11%)   0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     583          488          730 (T)      705         |665          721          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.262N     P=0.220      P=0.582      P=0.455N    |P=0.038N*    P=0.446N     P=0.044N*    P=0.368N     |
|POLY 3             |     P=0.237N     P=0.297      P=0.592      P=0.401N    |P=0.002N**   P=0.225N     P=0.013N*    P=0.020N*    |
|POLY 1.5           |     P=0.224N     P=0.281      P=0.596      P=0.391N    |P<0.001N**   P=0.190N     P=0.010N*    P=0.013N*    |
|POLY 6             |     P=0.252N     P=0.308      P=0.587      P=0.414N    |P=0.002N**   P=0.283N     P=0.017N*    P=0.042N*    |
|LOGISTIC REGRESSION|     P=0.226N     P=0.256      P=0.603      P=0.401N    |P=0.011N*    P=0.356N     P=0.022N*    P=0.096N     |
|COCH-ARM / FISHERS |     P=0.201N     P=0.251      P=0.584N     P=0.376N    |P=0.002N**   P=0.159N     P=0.007N**   P=0.006N**   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    5/50 (10%)   6/50 (12%)   5/50 (10%)  |0/50 (0%)    11/50 (22%)  24/49 (49%)  19/50 (38%)  |
|POLY-3 ADJUSTED (b)|     6.7%         10.8%        13.7%        11.4%       |0.0%         27.3%        57.5%        48.8%        |
|TERMINAL (d)       |     1/38 (3%)    4/36 (11%)   4/37 (11%)   3/35 (9%)   |0/31 (0%)    5/18 (28%)   12/18 (67%)  2/2 (100%)   |
|FIRST INCIDENCE    |     430          488          614          569         |---          605          484          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.297      P=0.350      P=0.244      P=0.334     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.302      P=0.378      P=0.231      P=0.346     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.314      P=0.375      P=0.234      P=0.354     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.293      P=0.376      P=0.229      P=0.339     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.351      P=0.247      P=0.268      P=0.394     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.337      P=0.369      P=0.254      P=0.369     |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Tension Lipidosis                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    1/36 (3%)    0/37 (0%)    0/35 (0%)   |2/31 (7%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      ---          ---         |731 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.575N     P=0.489      (e)          (e)         |P=0.283N     P=0.364N     P=0.364N     P=0.873N     |
|POLY 3             |     P=0.561N     P=0.511      (e)          (e)         |P=0.101N     P=0.271N     P=0.268N     P=0.299N     |
|POLY 1.5           |     P=0.562N     P=0.509      (e)          (e)         |P=0.107N     P=0.254N     P=0.255N     P=0.268N     |
|POLY 6             |     P=0.561N     P=0.511      (e)          (e)         |P=0.091N     P=0.298N     P=0.286N     P=0.353N     |
|LOGISTIC REGRESSION|     (e)          P=0.489      (e)          (e)         |P=0.283N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.562N     P=0.505      (e)          (e)         |P=0.117N     P=0.247N     P=0.253N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    6/49 (12%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         2.3%         0.0%        |2.2%         2.6%         15.3%        8.4%         |
|TERMINAL (d)       |     0/38 (0%)    1/36 (3%)    1/37 (3%)    0/35 (0%)   |1/31 (3%)    1/18 (6%)    3/18 (17%)   0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      730 (T)      ---         |731 (T)      731 (T)      714          379          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.608N     P=0.489      P=0.495      (e)         |P<0.001 **   P=0.636      P=0.012 *    P=0.029 *    |
|POLY 3             |     P=0.596N     P=0.511      P=0.500      (e)         |P=0.082      P=0.727      P=0.037 *    P=0.229      |
|POLY 1.5           |     P=0.594N     P=0.509      P=0.500      (e)         |P=0.115      P=0.744      P=0.044 *    P=0.265      |
|POLY 6             |     P=0.599N     P=0.511      P=0.500      (e)         |P=0.043 *    P=0.701      P=0.028 *    P=0.178      |
|LOGISTIC REGRESSION|     (e)          P=0.489      P=0.495      (e)         |P=0.077      P=0.636      P=0.015 *    P=0.368      |
|COCH-ARM / FISHERS |     P=0.590N     P=0.505      P=0.505      (e)         |P=0.159      P=0.753N     P=0.053      P=0.309      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    11/49 (22%)  9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         0.0%         2.3%        |2.2%         2.6%         27.1%        24.3%        |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |1/31 (3%)    1/18 (6%)    6/18 (33%)   1/2 (50%)    |
|FIRST INCIDENCE    |     ---          614          ---          660         |731 (T)      731 (T)      597          518          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.398      P=0.528      (e)          P=0.500     |P<0.001 **   P=0.636      P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.405      P=0.512      (e)          P=0.501     |P<0.001 **   P=0.727      P<0.001 **   P=0.003 **   |
|POLY 1.5           |     P=0.407      P=0.510      (e)          P=0.502     |P<0.001 **   P=0.744      P<0.001 **   P=0.005 **   |
|POLY 6             |     P=0.403      P=0.514      (e)          P=0.499     |P<0.001 **   P=0.701      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.425      P=0.429      (e)          P=0.512     |P<0.001 **   P=0.636      P<0.001 **   P=0.010 *    |
|COCH-ARM / FISHERS |     P=0.410      P=0.505      (e)          P=0.505     |P<0.001 **   P=0.753N     P=0.002 **   P=0.008 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/49 (16%)   14/50 (28%)  8/50 (16%)   10/50 (20%) |5/50 (10%)   9/50 (18%)   16/49 (33%)  17/50 (34%)  |
|POLY-3 ADJUSTED (b)|     17.3%        28.8%        17.6%        22.6%       |11.0%        21.6%        37.2%        42.3%        |
|TERMINAL (d)       |     3/38 (8%)    5/36 (14%)   4/37 (11%)   7/35 (20%)  |2/31 (7%)    1/18 (6%)    3/18 (17%)   0/2 (0%)     |
|FIRST INCIDENCE    |     430          488          522          512         |632          493          465          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.497      P=0.148      P=0.587      P=0.358     |P<0.001 **   P=0.077      P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.486      P=0.141      P=0.594      P=0.359     |P<0.001 **   P=0.145      P=0.003 **   P<0.001 **   |
|POLY 1.5           |     P=0.514      P=0.134      P=0.597      P=0.380     |P<0.001 **   P=0.168      P=0.004 **   P<0.001 **   |
|POLY 6             |     P=0.458      P=0.147      P=0.594      P=0.337     |P<0.001 **   P=0.115      P=0.002 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.474N     P=0.041 *    P=0.513N     P=0.444     |P=0.006 **   P=0.256      P=0.008 **   P=0.008 **   |
|COCH-ARM / FISHERS |     P=0.528N     P=0.124      P=0.590N     P=0.416     |P=0.002 **   P=0.194      P=0.005 **   P=0.004 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte                                                                                                                |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/49 (14%)   7/50 (14%)   2/50 (4%)    13/50 (26%) |20/50 (40%)  14/50 (28%)  11/49 (22%)  12/50 (24%)  |
|POLY-3 ADJUSTED (b)|     15.8%        14.8%        4.6%         29.6%       |42.5%        33.6%        25.5%        30.7%        |
|TERMINAL (d)       |     6/38 (16%)   3/36 (8%)    2/37 (5%)    12/35 (34%) |13/31 (42%)  7/18 (39%)   2/18 (11%)   0/2 (0%)     |
|FIRST INCIDENCE    |     430          488          730 (T)      512         |178          477          465          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.050      P=0.600      P=0.089N     P=0.074     |P=0.155      P=0.484      P=0.321N     P=0.046 *    |
|POLY 3             |     P=0.051      P=0.561N     P=0.083N     P=0.097     |P=0.117N     P=0.258N     P=0.066N     P=0.179N     |
|POLY 1.5           |     P=0.055      P=0.575N     P=0.082N     P=0.103     |P=0.088N     P=0.201N     P=0.057N     P=0.117N     |
|POLY 6             |     P=0.047 *    P=0.549N     P=0.083N     P=0.091     |P=0.178N     P=0.359N     P=0.080N     P=0.311N     |
|LOGISTIC REGRESSION|     P=0.064      P=0.574      P=0.079N     P=0.107     |P=0.023N*    P=0.121N     P=0.020N*    P=0.035N*    |
|COCH-ARM / FISHERS |     P=0.068      P=0.597N     P=0.075N     P=0.115     |P=0.061N     P=0.146N     P=0.047N*    P=0.066N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Hepatocyte, Centrilobular                                                                                                 |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          554         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.046 *    (e)          (e)          P=0.242     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.045 *    (e)          (e)          P=0.241     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.045 *    (e)          (e)          P=0.241     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.045 *    (e)          (e)          P=0.241     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.049 *    (e)          (e)          P=0.267     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.047 *    (e)          (e)          P=0.253     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Oval Cell                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    8/50 (16%)   27/50 (54%)  46/50 (92%) |0/50 (0%)    46/50 (92%)  36/49 (73%)  38/50 (76%)  |
|POLY-3 ADJUSTED (b)|     0.0%         17.2%        58.1%        96.2%       |0.0%         94.3%        76.0%        80.5%        |
|TERMINAL (d)       |     0/38 (0%)    4/36 (11%)   19/37 (51%)  34/35 (97%) |0/31 (0%)    17/18 (94%)  11/18 (61%)  1/2 (50%)    |
|FIRST INCIDENCE    |     ---          670          486          512         |---          477          465          379          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.005 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.006 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.003 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Portal                                                                                                                    |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    7/50 (14%)   46/50 (92%) |0/50 (0%)    10/50 (20%)  7/49 (14%)   23/50 (46%)  |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         15.8%        95.5%       |0.0%         24.6%        16.9%        54.4%        |
|TERMINAL (d)       |     0/38 (0%)    1/36 (3%)    4/37 (11%)   34/35 (97%) |0/31 (0%)    4/18 (22%)   1/18 (6%)    1/2 (50%)    |
|FIRST INCIDENCE    |     ---          730 (T)      575          512         |---          516          465          379          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.489      P=0.011 *    P<0.001 **  |P<0.001 **   P<0.001 **   P=0.004 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.511      P=0.008 **   P<0.001 **  |P<0.001 **   P<0.001 **   P=0.005 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.509      P=0.008 **   P<0.001 **  |P<0.001 **   P<0.001 **   P=0.006 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.511      P=0.008 **   P<0.001 **  |P<0.001 **   P<0.001 **   P=0.004 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.489      P=0.010 *    P<0.001 **  |P<0.001 **   P=0.002 **   P=0.010 *    P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.505      P=0.007 **   P<0.001 **  |P<0.001 **   P<0.001 **   P=0.006 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/48 (0%)    2/45 (4%)    |
|POLY-3 ADJUSTED (b)|     4.6%         4.4%         0.0%         0.0%        |0.0%         2.6%         0.0%         6.3%         |
|TERMINAL (d)       |     2/38 (5%)    2/36 (6%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          ---         |---          596          ---          652          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.093N     P=0.676      P=0.244N     P=0.257N    |P=0.102      P=0.473      (e)          P=0.148      |
|POLY 3             |     P=0.086N     P=0.675N     P=0.237N     P=0.238N    |P=0.095      P=0.473      (e)          P=0.168      |
|POLY 1.5           |     P=0.085N     P=0.678N     P=0.238N     P=0.236N    |P=0.106      P=0.486      (e)          P=0.189      |
|POLY 6             |     P=0.086N     P=0.674N     P=0.237N     P=0.240N    |P=0.080      P=0.454      (e)          P=0.141      |
|LOGISTIC REGRESSION|     P=0.093N     P=0.676      (e)          (e)         |P=0.138      P=0.507      (e)          P=0.209      |
|COCH-ARM / FISHERS |     P=0.083N     P=0.684N     P=0.242N     P=0.242N    |P=0.122      P=0.500      (e)          P=0.222      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/48 (0%)    0/45 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         4.3%         0.0%         2.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    1/36 (3%)    0/37 (0%)    1/35 (3%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          614          ---          730 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.526      P=0.249      (e)          P=0.484     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.540      P=0.251      (e)          P=0.499     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.542      P=0.248      (e)          P=0.501     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.536      P=0.253      (e)          P=0.497     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.546      P=0.218      (e)          P=0.484     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.546      P=0.253      (e)          P=0.505     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/49 (14%)   6/50 (12%)   5/50 (10%)   5/50 (10%)  |2/50 (4%)    1/50 (2%)    0/48 (0%)    0/45 (0%)    |
|POLY-3 ADJUSTED (b)|     15.9%        13.1%        11.5%        11.4%       |4.5%         2.6%         0.0%         0.0%         |
|TERMINAL (d)       |     6/38 (16%)   6/36 (17%)   5/37 (14%)   4/35 (11%)  |2/31 (7%)    1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     554          730 (T)      730 (T)      554         |731 (T)      731 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.355N     P=0.535N     P=0.396N     P=0.426N    |P=0.338N     P=0.687N     P=0.364N     P=0.873N     |
|POLY 3             |     P=0.324N     P=0.468N     P=0.389N     P=0.380N    |P=0.117N     P=0.551N     P=0.277N     P=0.323N     |
|POLY 1.5           |     P=0.318N     P=0.473N     P=0.386N     P=0.375N    |P=0.114N     P=0.526N     P=0.263N     P=0.293N     |
|POLY 6             |     P=0.330N     P=0.472N     P=0.393N     P=0.388N    |P=0.122N     P=0.587N     P=0.296N     P=0.376N     |
|LOGISTIC REGRESSION|     P=0.328N     P=0.458N     P=0.379N     P=0.373N    |P=0.338N     P=0.687N     (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.302N     P=0.484N     P=0.365N     P=0.365N    |P=0.111N     P=0.500N     P=0.258N     P=0.274N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolus                                                                                                                   |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    1/50 (2%)    0/50 (0%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    2/48 (4%)    4/45 (9%)    |
|POLY-3 ADJUSTED (b)|     4.6%         2.2%         0.0%         4.6%        |2.2%         2.6%         5.3%         12.6%        |
|TERMINAL (d)       |     1/38 (3%)    1/36 (3%)    0/37 (0%)    2/35 (6%)   |1/31 (3%)    1/18 (6%)    1/18 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     670          730 (T)      ---          730 (T)     |731 (T)      731 (T)      652          678          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.569      P=0.504N     P=0.245N     P=0.669     |P<0.001 **   P=0.636      P=0.347      P=0.003 **   |
|POLY 3             |     P=0.584      P=0.483N     P=0.239N     P=0.691     |P=0.034 *    P=0.727      P=0.443      P=0.092      |
|POLY 1.5           |     P=0.587      P=0.486N     P=0.238N     P=0.693N    |P=0.042 *    P=0.744      P=0.462      P=0.116      |
|POLY 6             |     P=0.581      P=0.484N     P=0.239N     P=0.686     |P=0.024 *    P=0.701      P=0.419      P=0.064      |
|LOGISTIC REGRESSION|     P=0.581      P=0.484N     P=0.236N     P=0.693     |P=0.012 *    P=0.636      P=0.433      P=0.030 *    |
|COCH-ARM / FISHERS |     P=0.596      P=0.492N     P=0.242N     P=0.684N    |P=0.054      P=0.753N     P=0.485      P=0.150      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mandibular                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/46 (0%)    2/47 (4%)    0/45 (0%)   |1/49 (2%)    0/43 (0%)    0/41 (0%)    0/32 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.8%         0.0%        |2.3%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/34 (0%)    2/37 (5%)    0/34 (0%)   |0/30 (0%)    0/18 (0%)    0/17 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          730 (T)      ---         |652          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.578      (e)          P=0.232      (e)         |P=0.352N     P=0.576N     P=0.551N     P=0.583N     |
|POLY 3             |     P=0.579      (e)          P=0.229      (e)         |P=0.318N     P=0.551N     P=0.561N     P=0.634N     |
|POLY 1.5           |     P=0.580      (e)          P=0.228      (e)         |P=0.335N     P=0.539N     P=0.550N     P=0.612N     |
|POLY 6             |     P=0.578      (e)          P=0.232      (e)         |P=0.285N     P=0.567N     P=0.574N     P=0.665N     |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.232      (e)         |P=0.339N     P=0.514N     P=0.520N     P=0.567N     |
|COCH-ARM / FISHERS |     P=0.583      (e)          P=0.242      (e)         |P=0.354N     P=0.533N     P=0.544N     P=0.605N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mediastinal                                                                                                          |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |2/31 (7%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.283N     P=0.364N     P=0.364N     P=0.873N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.101N     P=0.271N     P=0.267N     P=0.299N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.107N     P=0.254N     P=0.253N     P=0.268N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.092N     P=0.298N     P=0.286N     P=0.353N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.283N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.116N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/46 (2%)    1/49 (2%)    0/50 (0%)   |1/47 (2%)    2/48 (4%)    1/43 (2%)    0/36 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.4%         2.3%         0.0%        |2.4%         5.3%         2.9%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    1/34 (3%)    1/37 (3%)    0/35 (0%)   |1/29 (3%)    1/18 (6%)    1/17 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      730 (T)      ---         |731 (T)      632          731 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.604N     P=0.478      P=0.495      (e)         |P=0.623N     P=0.356      P=0.638      P=0.962N     |
|POLY 3             |     P=0.590N     P=0.493      P=0.500      (e)         |P=0.371N     P=0.464      P=0.719      P=0.596N     |
|POLY 1.5           |     P=0.587N     P=0.491      P=0.500      (e)         |P=0.340N     P=0.485      P=0.730      P=0.575N     |
|POLY 6             |     P=0.593N     P=0.493      P=0.500      (e)         |P=0.422N     P=0.434      P=0.704      P=0.628N     |
|LOGISTIC REGRESSION|     (e)          P=0.478      P=0.495      (e)         |P=0.410N     P=0.463      P=0.638      (e)          |
|COCH-ARM / FISHERS |     P=0.584N     P=0.484      P=0.500      (e)         |P=0.309N     P=0.508      P=0.730      P=0.566N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/46 (0%)    1/49 (2%)    0/50 (0%)   |0/47 (0%)    1/48 (2%)    1/43 (2%)    0/36 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         0.0%         2.3%         0.0%        |0.0%         2.7%         2.9%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/34 (0%)    1/37 (3%)    0/35 (0%)   |0/29 (0%)    1/18 (6%)    1/17 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     570          ---          730 (T)      ---         |---          731 (T)      731 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.199N     P=0.218N     P=0.500N     P=0.245N    |P=0.449      P=0.405      P=0.393      (e)          |
|POLY 3             |     P=0.190N     P=0.250N     P=0.509N     P=0.243N    |P=0.630      P=0.477      P=0.463      (e)          |
|POLY 1.5           |     P=0.188N     P=0.250N     P=0.505N     P=0.239N    |P=0.679      P=0.491      P=0.473      (e)          |
|POLY 6             |     P=0.191N     P=0.252N     P=0.513N     P=0.248N    |P=0.537      P=0.459      P=0.451      (e)          |
|LOGISTIC REGRESSION|     P=0.157N     P=0.361N     P=0.480N     P=0.183N    |(e)          P=0.405      P=0.393      (e)          |
|COCH-ARM / FISHERS |     P=0.184N     P=0.263N     P=0.500N     P=0.242N    |P=0.655N     P=0.505      P=0.478      (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/46 (0%)    2/49 (4%)    1/50 (2%)   |0/47 (0%)    0/48 (0%)    0/43 (0%)    0/36 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.6%         2.3%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/34 (0%)    2/37 (5%)    0/35 (0%)   |0/29 (0%)    0/18 (0%)    0/17 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          730 (T)      660         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.237      (e)          P=0.232      P=0.500     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.245      (e)          P=0.237      P=0.501     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.248      (e)          P=0.237      P=0.502     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.242      (e)          P=0.237      P=0.499     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.249      (e)          P=0.232      P=0.512     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.255      (e)          P=0.247      P=0.505     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Lymph Node, Mesenteric                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    2/46 (4%)    0/49 (0%)    1/50 (2%)   |1/47 (2%)    1/48 (2%)    0/43 (0%)    0/36 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         4.7%         0.0%         2.3%        |2.4%         2.6%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/34 (0%)    0/37 (0%)    0/35 (0%)   |0/29 (0%)    0/18 (0%)    0/17 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     430          673          ---          339         |695          493          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.306N     P=0.673N     P=0.244N     P=0.505N    |P=0.316N     P=0.709      P=0.570N     P=0.759N     |
|POLY 3             |     P=0.292N     P=0.674      P=0.244N     P=0.504N    |P=0.285N     P=0.739      P=0.537N     P=0.596N     |
|POLY 1.5           |     P=0.289N     P=0.673      P=0.242N     P=0.499N    |P=0.280N     P=0.752      P=0.528N     P=0.575N     |
|POLY 6             |     P=0.295N     P=0.674      P=0.246N     P=0.511N    |P=0.289N     P=0.717      P=0.550N     P=0.629N     |
|LOGISTIC REGRESSION|     P=0.165N     P=0.522      P=0.148N     P=0.324N    |P=0.264N     P=0.759N     P=0.527N     P=0.616N     |
|COCH-ARM / FISHERS |     P=0.285N     P=0.667      P=0.247N     P=0.492N    |P=0.274N     P=0.747N     P=0.522N     P=0.566N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/1 (0%)     0/2 (0%)     1/1 (100%)   0/1 (0%)    |6/13 (46%)   3/7 (43%)    1/3 (33%)    1/3 (33%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         100.0%       0.0%        |48.6%        54.0%        49.4%        44.4%        |
|TERMINAL (d)       |     0/1 (0%)     0/2 (0%)     1/1 (100%)   0/0 (0%)    |3/6 (50%)    1/1 (100%)   0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          ---          730 (T)      ---         |632          617          641          588          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.496      (e)          P=0.500      (e)         |P=0.397N     P=0.548      P=0.422N     P=0.579N     |
|POLY 3             |     P=1.000N     (e)          P=1.000      (e)         |P=0.603N     P=0.612      P=0.736      P=0.706N     |
|POLY 1.5           |     P=1.000N     (e)          P=1.000      (e)         |P=0.523N     P=0.662      P=0.687N     P=0.654N     |
|POLY 6             |     P=1.000N     (e)          P=1.000      (e)         |P=0.537      P=0.539      P=0.680      P=0.718      |
|LOGISTIC REGRESSION|     (e)          (e)          P=0.250      (e)         |P=0.614N     P=0.667      P=0.803N     P=0.591N     |
|COCH-ARM / FISHERS |     P=0.688      (e)          P=0.500      (e)         |P=0.429N     P=0.630N     P=0.600N     P=0.600N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/49 (18%)   13/50 (26%)  11/50 (22%)  10/50 (20%) |8/50 (16%)   11/50 (22%)  13/49 (27%)  11/47 (23%)  |
|POLY-3 ADJUSTED (b)|     20.2%        27.0%        24.0%        23.1%       |17.4%        27.5%        30.5%        31.9%        |
|TERMINAL (d)       |     7/38 (18%)   7/36 (19%)   6/37 (16%)   10/35 (29%) |3/31 (10%)   3/18 (17%)   3/18 (17%)   1/2 (50%)    |
|FIRST INCIDENCE    |     540          546          522          730 (T)     |630          605          484          577          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.495      P=0.253      P=0.395      P=0.429     |P=0.002 **   P=0.075      P=0.052      P<0.001 **   |
|POLY 3             |     P=0.502      P=0.303      P=0.431      P=0.473     |P=0.082      P=0.194      P=0.115      P=0.105      |
|POLY 1.5           |     P=0.530      P=0.283      P=0.417      P=0.492     |P=0.139      P=0.245      P=0.130      P=0.165      |
|POLY 6             |     P=0.469      P=0.323      P=0.448      P=0.449     |P=0.032 *    P=0.135      P=0.100      P=0.047 *    |
|LOGISTIC REGRESSION|     P=0.509N     P=0.205      P=0.439      P=0.497     |P=0.178      P=0.231      P=0.200      P=0.122      |
|COCH-ARM / FISHERS |     P=0.516N     P=0.251      P=0.421      P=0.520     |P=0.230      P=0.306      P=0.150      P=0.254      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Nasolacrimal Duct                                                                                                          |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    2/50 (4%)    8/50 (16%)   2/50 (4%)   |4/50 (8%)    15/50 (30%)  11/49 (22%)  12/47 (26%)  |
|POLY-3 ADJUSTED (b)|     9.1%         4.4%         18.1%        4.5%        |8.8%         35.6%        28.0%        33.5%        |
|TERMINAL (d)       |     3/38 (8%)    1/36 (3%)    5/37 (14%)   0/35 (0%)   |1/31 (3%)    4/18 (22%)   5/18 (28%)   0/2 (0%)     |
|FIRST INCIDENCE    |     583          729          572          569         |665          562          637          518          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.468N     P=0.348N     P=0.181      P=0.359N    |P<0.001 **   P<0.001 **   P=0.007 **   P<0.001 **   |
|POLY 3             |     P=0.437N     P=0.318N     P=0.179      P=0.332N    |P=0.018 *    P=0.002 **   P=0.020 *    P=0.005 **   |
|POLY 1.5           |     P=0.433N     P=0.320N     P=0.178      P=0.331N    |P=0.037 *    P=0.003 **   P=0.027 *    P=0.009 **   |
|POLY 6             |     P=0.439N     P=0.319N     P=0.182      P=0.334N    |P=0.005 **   P<0.001 **   P=0.012 *    P=0.002 **   |
|LOGISTIC REGRESSION|     P=0.416N     P=0.320N     P=0.182      P=0.305N    |P=0.044 *    P=0.007 **   P=0.015 *    P=0.020 *    |
|COCH-ARM / FISHERS |     P=0.422N     P=0.329N     P=0.188      P=0.329N    |P=0.078      P=0.005 **   P=0.041 *    P=0.019 *    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |12/50 (24%)  7/49 (14%)   7/48 (15%)   4/41 (10%)   |
|POLY-3 ADJUSTED (b)|                                                        |26.6%        18.2%        17.9%        14.0%        |
|TERMINAL (d)       |                                                        |10/31 (32%)  5/17 (29%)   2/18 (11%)   0/2 (0%)     |
|FIRST INCIDENCE    |                                                        |630          519          521          654          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.375      P=0.600N     P=0.508N     P=0.191      |
|POLY 3             |                                                        |P=0.118N     P=0.256N     P=0.246N     P=0.164N     |
|POLY 1.5           |                                                        |P=0.086N     P=0.207N     P=0.213N     P=0.109N     |
|POLY 6             |                                                        |P=0.182N     P=0.339N     P=0.289N     P=0.280N     |
|LOGISTIC REGRESSION|                                                        |P=0.163N     P=0.344N     P=0.249N     P=0.435N     |
|COCH-ARM / FISHERS |                                                        |P=0.059N     P=0.166N     P=0.178N     P=0.065N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |0/50 (0%)    0/49 (0%)    0/48 (0%)    2/41 (5%)    |
|POLY-3 ADJUSTED (b)|                                                        |0.0%         0.0%         0.0%         7.1%         |
|TERMINAL (d)       |                                                        |0/31 (0%)    0/17 (0%)    0/18 (0%)    1/2 (50%)    |
|FIRST INCIDENCE    |                                                        |---          ---          ---          603          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.006 **   (e)          (e)          P=0.035 *    |
|POLY 3             |                                                        |P=0.028 *    (e)          (e)          P=0.148      |
|POLY 1.5           |                                                        |P=0.029 *    (e)          (e)          P=0.168      |
|POLY 6             |                                                        |P=0.026 *    (e)          (e)          P=0.122      |
|LOGISTIC REGRESSION|                                                        |P=0.028 *    (e)          (e)          P=0.180      |
|COCH-ARM / FISHERS |                                                        |P=0.033 *    (e)          (e)          P=0.200      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    4/49 (8%)    0/50 (0%)    4/50 (8%)   |10/49 (20%)  15/50 (30%)  13/46 (28%)  2/46 (4%)    |
|POLY-3 ADJUSTED (b)|     2.3%         8.9%         0.0%         9.2%        |22.6%        38.4%        32.7%        6.1%         |
|TERMINAL (d)       |     1/38 (3%)    4/36 (11%)   0/37 (0%)    4/35 (11%)  |10/31 (32%)  13/18 (72%)  7/18 (39%)   0/2 (0%)     |
|FIRST INCIDENCE    |     730 (T)      730 (T)      ---          730 (T)     |731 (T)      596          520          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.203      P=0.163      P=0.505N     P=0.155     |P=0.143      P=0.002 **   P=0.043 *    P=0.397      |
|POLY 3             |     P=0.226      P=0.189      P=0.500N     P=0.177     |P=0.050N     P=0.087      P=0.214      P=0.046N*    |
|POLY 1.5           |     P=0.229      P=0.186      P=0.500N     P=0.180     |P=0.025N*    P=0.132      P=0.237      P=0.030N*    |
|POLY 6             |     P=0.222      P=0.190      P=0.500N     P=0.174     |P=0.138N     P=0.042 *    P=0.184      P=0.090N     |
|LOGISTIC REGRESSION|     P=0.203      P=0.163      (e)          P=0.155     |P=0.081N     P=0.009 **   P=0.212      P=0.139N     |
|COCH-ARM / FISHERS |     P=0.237      P=0.181      P=0.495N     P=0.187     |P=0.013N*    P=0.193      P=0.257      P=0.018N*    |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas: Acinus                                                                                                                 |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/49 (0%)    1/50 (2%)    0/46 (0%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     6.9%         0.0%         0.0%         0.0%        |0.0%         2.6%         0.0%         0.0%         |
|TERMINAL (d)       |     3/38 (8%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     730 (T)      ---          ---          ---         |---          731 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.052N     P=0.131N     P=0.126N     P=0.136N    |P=0.823      P=0.392      (e)          (e)          |
|POLY 3             |     P=0.046N*    P=0.112N     P=0.119N     P=0.119N    |P=0.604N     P=0.473      (e)          (e)          |
|POLY 1.5           |     P=0.046N*    P=0.114N     P=0.119N     P=0.118N    |P=0.592N     P=0.488      (e)          (e)          |
|POLY 6             |     P=0.046N*    P=0.111N     P=0.118N     P=0.121N    |P=0.616N     P=0.451      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.052N     (e)          (e)          (e)         |(e)          P=0.392      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.047N*    P=0.121N     P=0.117N     P=0.117N    |P=0.576N     P=0.505      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/45 (0%)    0/48 (0%)    0/44 (0%)    0/45 (0%)   |7/48 (15%)   0/44 (0%)    0/44 (0%)    0/40 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |16.3%        0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/36 (0%)    0/34 (0%)    0/34 (0%)    0/33 (0%)   |7/30 (23%)   0/18 (0%)    0/17 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.017N*    P=0.038N*    P=0.043N*    P=0.543N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P<0.001N**   P=0.017N*    P=0.016N*    P=0.032N*    |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.002N**   P=0.013N*    P=0.013N*    P=0.022N*    |
|POLY 6             |     (e)          (e)          (e)          (e)         |P<0.001N**   P=0.022N*    P=0.021N*    P=0.056N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.017N*    (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.003N**   P=0.008N**   P=0.008N**   P=0.012N*    |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/45 (11%)   7/48 (15%)   3/44 (7%)    1/45 (2%)   |1/48 (2%)    0/44 (0%)    1/44 (2%)    1/40 (3%)    |
|POLY-3 ADJUSTED (b)|     12.3%        16.0%        7.7%         2.5%        |2.3%         0.0%         2.9%         3.5%         |
|TERMINAL (d)       |     4/36 (11%)   7/34 (21%)   3/34 (9%)    1/33 (3%)   |1/30 (3%)    0/18 (0%)    0/17 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     580          730 (T)      730 (T)      730 (T)     |731 (T)      ---          661          676          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.047N*    P=0.348      P=0.384N     P=0.123N    |P=0.314      P=0.602N     P=0.654      P=0.460      |
|POLY 3             |     P=0.042N*    P=0.432      P=0.376N     P=0.104N    |P=0.439      P=0.544N     P=0.713      P=0.662      |
|POLY 1.5           |     P=0.041N*    P=0.432      P=0.378N     P=0.102N    |P=0.466      P=0.531N     P=0.726      P=0.690      |
|POLY 6             |     P=0.044N*    P=0.422      P=0.376N     P=0.108N    |P=0.395      P=0.560N     P=0.696      P=0.617      |
|LOGISTIC REGRESSION|     P=0.042N*    P=0.438      P=0.370N     P=0.103N    |P=0.443      (e)          P=0.729      P=0.638      |
|COCH-ARM / FISHERS |     P=0.041N*    P=0.426      P=0.370N     P=0.101N    |P=0.495      P=0.522N     P=0.731      P=0.705      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/45 (0%)    0/48 (0%)    0/44 (0%)    0/45 (0%)   |6/48 (13%)   8/44 (18%)   3/44 (7%)    3/40 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |13.9%        23.0%        8.6%         10.5%        |
|TERMINAL (d)       |     0/36 (0%)    0/34 (0%)    0/34 (0%)    0/33 (0%)   |5/30 (17%)   7/18 (39%)   1/17 (6%)    1/2 (50%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |670          620          659          615          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.188      P=0.091      P=0.528N     P=0.113      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.258N     P=0.230      P=0.355N     P=0.476N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.205N     P=0.272      P=0.323N     P=0.409N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.353N     P=0.180      P=0.399N     P=0.579N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.440N     P=0.144      P=0.417N     P=0.645      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.156N     P=0.320      P=0.288N     P=0.342N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/49 (14%)   6/50 (12%)   10/50 (20%)  5/50 (10%)  |                                                    |
|POLY-3 ADJUSTED (b)|     15.9%        13.1%        22.3%        11.5%       |                                                    |
|TERMINAL (d)       |     6/38 (16%)   5/36 (14%)   6/37 (16%)   4/35 (11%)  |                                                    |
|FIRST INCIDENCE    |     580          694          572          673         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.445N     P=0.525N     P=0.296      P=0.430N    |                                                    |
|POLY 3             |     P=0.414N     P=0.465N     P=0.313      P=0.385N    |                                                    |
|POLY 1.5           |     P=0.403N     P=0.471N     P=0.305      P=0.378N    |                                                    |
|POLY 6             |     P=0.425N     P=0.466N     P=0.326      P=0.394N    |                                                    |
|LOGISTIC REGRESSION|     P=0.398N     P=0.459N     P=0.304      P=0.381N    |                                                    |
|COCH-ARM / FISHERS |     P=0.379N     P=0.484N     P=0.314      P=0.365N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     17/49 (35%)  15/50 (30%)  14/50 (28%)  18/50 (36%) |                                                    |
|POLY-3 ADJUSTED (b)|     37.4%        31.7%        31.8%        40.2%       |                                                    |
|TERMINAL (d)       |     13/38 (34%)  11/36 (31%)  13/37 (35%)  15/35 (43%) |                                                    |
|FIRST INCIDENCE    |     537          488          522          339         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.339      P=0.444N     P=0.363N     P=0.408     |                                                    |
|POLY 3             |     P=0.369      P=0.361N     P=0.372N     P=0.476     |                                                    |
|POLY 1.5           |     P=0.398      P=0.368N     P=0.355N     P=0.502     |                                                    |
|POLY 6             |     P=0.332      P=0.366N     P=0.395N     P=0.436     |                                                    |
|LOGISTIC REGRESSION|     P=0.417      P=0.403N     P=0.329N     P=0.521     |                                                    |
|COCH-ARM / FISHERS |     P=0.441      P=0.388N     P=0.308N     P=0.530     |                                                    |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    4/50 (8%)    8/50 (16%)   2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     6.9%         8.7%         18.0%        4.6%        |                                                    |
|TERMINAL (d)       |     3/38 (8%)    4/36 (11%)   6/37 (16%)   2/35 (6%)   |                                                    |
|FIRST INCIDENCE    |     730 (T)      730 (T)      572          730 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.491N     P=0.470      P=0.099      P=0.538N    |                                                    |
|POLY 3             |     P=0.467N     P=0.529      P=0.104      P=0.501N    |                                                    |
|POLY 1.5           |     P=0.457N     P=0.523      P=0.101      P=0.497N    |                                                    |
|POLY 6             |     P=0.477N     P=0.531      P=0.108      P=0.506N    |                                                    |
|LOGISTIC REGRESSION|     P=0.462N     P=0.470      P=0.101      P=0.538N    |                                                    |
|COCH-ARM / FISHERS |     P=0.439N     P=0.511      P=0.106      P=0.490N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     4.5%         4.3%         0.0%         0.0%        |                                                    |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |                                                    |
|FIRST INCIDENCE    |     570          614          ---          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.091N     P=0.664N     P=0.240N     P=0.248N    |                                                    |
|POLY 3             |     P=0.087N     P=0.676N     P=0.241N     P=0.241N    |                                                    |
|POLY 1.5           |     P=0.086N     P=0.679N     P=0.240N     P=0.238N    |                                                    |
|POLY 6             |     P=0.089N     P=0.675N     P=0.243N     P=0.246N    |                                                    |
|LOGISTIC REGRESSION|     P=0.073N     P=0.628      P=0.204N     P=0.213N    |                                                    |
|COCH-ARM / FISHERS |     P=0.083N     P=0.684N     P=0.242N     P=0.242N    |                                                    |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Salivary Glands                                                                                                                  |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     31/49 (63%)  29/50 (58%)  28/50 (56%)  34/50 (68%) |33/50 (66%)  29/45 (64%)  27/44 (61%)  18/42 (43%)  |
|POLY-3 ADJUSTED (b)|     67.0%        61.5%        62.4%        74.2%       |71.0%        73.7%        64.8%        50.8%        |
|TERMINAL (d)       |     25/38 (66%)  24/36 (67%)  24/37 (65%)  26/35 (74%) |24/31 (77%)  16/18 (89%)  9/18 (50%)   1/2 (50%)    |
|FIRST INCIDENCE    |     537          614          486          554         |610          477          371          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.164      P=0.490N     P=0.399N     P=0.222     |P=0.013 *    P=0.042 *    P=0.206      P=0.002 **   |
|POLY 3             |     P=0.198      P=0.366N     P=0.405N     P=0.291     |P=0.019N*    P=0.486      P=0.345N     P=0.041N*    |
|POLY 1.5           |     P=0.227      P=0.362N     P=0.378N     P=0.325     |P=0.014N*    P=0.577      P=0.360N     P=0.028N*    |
|POLY 6             |     P=0.177      P=0.385N     P=0.441N     P=0.264     |P=0.030N*    P=0.354      P=0.312N     P=0.075N     |
|LOGISTIC REGRESSION|     P=0.218      P=0.308N     P=0.338N     P=0.343     |P=0.027N*    P=0.263      P=0.450N     P=0.072N     |
|COCH-ARM / FISHERS |     P=0.296      P=0.371N     P=0.298N     P=0.388     |P=0.012N*    P=0.522N     P=0.400N     P=0.022N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skeletal Muscle                                                                                                                  |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/2 (50%)    0/1 (0%)     2/3 (67%)    1/3 (33%)   |0/2 (0%)     5/8 (63%)    1/3 (33%)    2/3 (67%)    |
|POLY-3 ADJUSTED (b)|     50.0%        0.0%         66.7%        35.2%       |0.0%         66.9%        34.0%        69.0%        |
|TERMINAL (d)       |     1/2 (50%)    0/1 (0%)     2/3 (67%)    1/2 (50%)   |0/0 (0%)     4/5 (80%)    1/1 (100%)   0/0 (0%)     |
|FIRST INCIDENCE    |     730 (T)      ---          730 (T)      730 (T)     |---          720          731 (T)      607          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.589      P=0.638N     P=0.691      P=0.807     |P=0.040 *    P=0.396      P=1.000N     P=0.149      |
|POLY 3             |     P=0.601N     P=0.614N     P=0.670      P=0.687N    |P=0.449      P=0.260      P=0.618      P=0.345      |
|POLY 1.5           |     P=0.591N     P=0.614N     P=0.670      P=0.679N    |P=0.402      P=0.231      P=0.598      P=0.312      |
|POLY 6             |     P=0.618N     P=0.614N     P=0.670      P=0.702N    |P=0.534      P=0.334      P=0.654      P=0.417      |
|LOGISTIC REGRESSION|     P=0.589      (e)          P=0.691      P=0.807     |P=0.271      (e)          P=1.000N     (e)          |
|COCH-ARM / FISHERS |     P=0.598N     P=0.667N     P=0.700      P=0.700N    |P=0.349      P=0.222      P=0.600      P=0.300      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    2/49 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.2%         0.0%         5.1%         5.7%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |1/31 (3%)    0/18 (0%)    2/18 (11%)   0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |731 (T)      ---          731 (T)      537          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.032 *    P=0.608N     P=0.313      P=0.245      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.189      P=0.529N     P=0.455      P=0.417      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.212      P=0.515N     P=0.476      P=0.453      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.152      P=0.550N     P=0.428      P=0.360      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.232      (e)          P=0.313      P=0.559      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.238      P=0.500N     P=0.500      P=0.492      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/46 (0%)    1/46 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         4.5%         0.0%        |0.0%         0.0%         0.0%         3.1%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          37           ---         |---          ---          ---          379          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.590      (e)          P=0.242      (e)         |P=0.200      (e)          (e)          P=0.504      |
|POLY 3             |     P=0.579      (e)          P=0.244      (e)         |P=0.166      (e)          (e)          P=0.438      |
|POLY 1.5           |     P=0.586      (e)          P=0.243      (e)         |P=0.177      (e)          (e)          P=0.460      |
|POLY 6             |     P=0.571      (e)          P=0.246      (e)         |P=0.150      (e)          (e)          P=0.403      |
|LOGISTIC REGRESSION|     P=0.719N     (e)          P=0.526      (e)         |P=0.087      (e)          (e)          P=0.393      |
|COCH-ARM / FISHERS |     P=0.598      (e)          P=0.253      (e)         |P=0.187      (e)          (e)          P=0.479      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Lymphoid Follicle                                                                                                        |
|     Depletion Cellular                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/49 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/46 (0%)    2/46 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         2.6%         0.0%         6.2%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          633          ---          676          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.083      P=0.436      (e)          P=0.121      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.098      P=0.472      (e)          P=0.171      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.110      P=0.486      (e)          P=0.192      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.083      P=0.453      (e)          P=0.142      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.125      P=0.516      (e)          P=0.178      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.126      P=0.500      (e)          P=0.227      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Lymphoid Follicle                                                                                                        |
|     Hyperplasia Lymphoid                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/49 (0%)    1/50 (2%)    3/50 (6%)   |8/50 (16%)   3/50 (6%)    2/46 (4%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         2.3%         6.9%        |17.9%        7.8%         5.4%         0.0%         |
|TERMINAL (d)       |     1/38 (3%)    0/36 (0%)    1/37 (3%)    1/35 (3%)   |7/31 (23%)   3/18 (17%)   2/18 (11%)   0/2 (0%)     |
|FIRST INCIDENCE    |     730 (T)      ---          730 (T)      705         |718          731 (T)      731 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.089      P=0.511N     P=0.756      P=0.287     |P=0.123N     P=0.344N     P=0.196N     P=0.466N     |
|POLY 3             |     P=0.093      P=0.493N     P=0.760      P=0.305     |P=0.004N**   P=0.150N     P=0.082N     P=0.015N*    |
|POLY 1.5           |     P=0.095      P=0.495N     P=0.760      P=0.308     |P=0.003N**   P=0.123N     P=0.071N     P=0.009N**   |
|POLY 6             |     P=0.091      P=0.492N     P=0.761      P=0.302     |P=0.007N**   P=0.198N     P=0.100N     P=0.033N*    |
|LOGISTIC REGRESSION|     P=0.089      (e)          P=0.756      P=0.297     |P=0.069N     P=0.303N     P=0.153N     P=0.232N     |
|COCH-ARM / FISHERS |     P=0.099      P=0.500N     P=0.747N     P=0.316     |P=0.003N**   P=0.100N     P=0.060N     P=0.004N**   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Lymphoid Follicle                                                                                                        |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/49 (6%)    6/49 (12%)   1/50 (2%)    2/50 (4%)   |0/50 (0%)    2/50 (4%)    4/46 (9%)    1/46 (2%)    |
|POLY-3 ADJUSTED (b)|     6.7%         12.8%        2.3%         4.5%        |0.0%         5.1%         10.2%        3.1%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     430          488          589          339         |---          493          465          607          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.228N     P=0.283      P=0.310N     P=0.509N    |P=0.327      P=0.213      P=0.053      P=0.447      |
|POLY 3             |     P=0.210N     P=0.264      P=0.314N     P=0.501N    |P=0.233      P=0.211      P=0.045 *    P=0.435      |
|POLY 1.5           |     P=0.206N     P=0.256      P=0.311N     P=0.497N    |P=0.302      P=0.224      P=0.048 *    P=0.458      |
|POLY 6             |     P=0.216N     P=0.272      P=0.316N     P=0.508N    |P=0.141      P=0.194      P=0.040 *    P=0.401      |
|LOGISTIC REGRESSION|     P=0.128N     P=0.086      P=0.201N     P=0.377N    |P=0.503      P=0.218      P=0.043 *    P=0.524      |
|COCH-ARM / FISHERS |     P=0.200N     P=0.243      P=0.301N     P=0.490N    |P=0.386      P=0.247      P=0.049 *    P=0.479      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen: Red Pulp                                                                                                                 |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/49 (20%)  20/49 (41%)  25/50 (50%)  19/50 (38%) |29/50 (58%)  40/50 (80%)  45/46 (98%)  44/46 (96%)  |
|POLY-3 ADJUSTED (b)|     21.5%        42.7%        52.3%        40.5%       |61.9%        82.8%        98.1%        98.9%        |
|TERMINAL (d)       |     4/38 (11%)   12/36 (33%)  16/37 (43%)  11/35 (31%) |17/31 (55%)  13/18 (72%)  18/18 (100%) 2/2 (100%)   |
|FIRST INCIDENCE    |     477          593          326          512         |632          477          465          450          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.063      P=0.042 *    P=0.005 **   P=0.045 *   |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P=0.060      P=0.023 *    P<0.001 **   P=0.038 *   |P<0.001 **   P=0.016 *    P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P=0.062      P=0.023 *    P<0.001 **   P=0.039 *   |P<0.001 **   P=0.016 *    P<0.001 **   P<0.001 **   |
|POLY 6             |     P=0.059      P=0.022 *    P<0.001 **   P=0.037 *   |P<0.001 **   P=0.016 *    P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P=0.090      P=0.014 *    P=0.003 **   P=0.049 *   |P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P=0.075      P=0.024 *    P=0.002 **   P=0.044 *   |P<0.001 **   P=0.015 *    P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    4/50 (8%)    0/50 (0%)   |1/50 (2%)    3/50 (6%)    0/48 (0%)    3/46 (7%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         8.9%         0.0%        |2.2%         7.7%         0.0%         9.1%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          694          522          ---         |670          617          ---          518          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.578      P=0.510      P=0.069      (e)         |P=0.104      P=0.188      P=0.564N     P=0.129      |
|POLY 3             |     P=0.573      P=0.511      P=0.065      (e)         |P=0.229      P=0.257      P=0.529N     P=0.206      |
|POLY 1.5           |     P=0.582      P=0.509      P=0.063      (e)         |P=0.259      P=0.280      P=0.519N     P=0.238      |
|POLY 6             |     P=0.562      P=0.512      P=0.067      (e)         |P=0.188      P=0.225      P=0.544N     P=0.160      |
|LOGISTIC REGRESSION|     P=0.615N     P=0.501      P=0.080      (e)         |P=0.312      P=0.294      P=0.501N     P=0.325      |
|COCH-ARM / FISHERS |     P=0.596      P=0.505      P=0.061      (e)         |P=0.293      P=0.309      P=0.510N     P=0.278      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    1/48 (2%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     4.6%         0.0%         6.8%         0.0%        |0.0%         5.1%         2.6%         0.0%         |
|TERMINAL (d)       |     2/38 (5%)    0/36 (0%)    1/37 (3%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     730 (T)      ---          522          ---         |---          582          694          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.314N     P=0.250N     P=0.495      P=0.257N    |P=0.580N     P=0.204      P=0.444      (e)          |
|POLY 3             |     P=0.308N     P=0.225N     P=0.510      P=0.238N    |P=0.570N     P=0.210      P=0.473      (e)          |
|POLY 1.5           |     P=0.302N     P=0.228N     P=0.505      P=0.236N    |P=0.527N     P=0.223      P=0.482      (e)          |
|POLY 6             |     P=0.312N     P=0.225N     P=0.515      P=0.240N    |P=0.596      P=0.193      P=0.460      (e)          |
|LOGISTIC REGRESSION|     P=0.282N     (e)          P=0.523      (e)         |P=0.441N     P=0.245      P=0.483      (e)          |
|COCH-ARM / FISHERS |     P=0.293N     P=0.242N     P=0.510      P=0.242N    |P=0.481N     P=0.247      P=0.490      (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/49 (10%)   2/50 (4%)    3/50 (6%)    2/50 (4%)   |1/50 (2%)    3/50 (6%)    2/48 (4%)    1/46 (2%)    |
|POLY-3 ADJUSTED (b)|     11.5%        4.4%         6.8%         4.6%        |2.2%         7.6%         5.1%         3.1%         |
|TERMINAL (d)       |     5/38 (13%)   1/36 (3%)    1/37 (3%)    2/35 (6%)   |0/31 (0%)    1/18 (6%)    1/18 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     730 (T)      729          522          730 (T)     |728          582          694          518          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.237N     P=0.239N     P=0.368N     P=0.249N    |P=0.377      P=0.191      P=0.348      P=0.545      |
|POLY 3             |     P=0.219N     P=0.194N     P=0.345N     P=0.216N    |P=0.576      P=0.262      P=0.452      P=0.687      |
|POLY 1.5           |     P=0.215N     P=0.199N     P=0.350N     P=0.214N    |P=0.559N     P=0.283      P=0.469      P=0.715      |
|POLY 6             |     P=0.221N     P=0.193N     P=0.337N     P=0.220N    |P=0.474      P=0.233      P=0.429      P=0.639      |
|LOGISTIC REGRESSION|     P=0.213N     P=0.222N     P=0.349N     P=0.249N    |P=0.480N     P=0.323      P=0.408      P=0.744N     |
|COCH-ARM / FISHERS |     P=0.205N     P=0.210N     P=0.346N     P=0.210N    |P=0.508N     P=0.309      P=0.485      P=0.731      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    0/48 (0%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.3%         0.0%        |0.0%         5.1%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          522          ---         |---          582          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.692      (e)          P=0.500      (e)         |P=0.442N     P=0.204      (e)          (e)          |
|POLY 3             |     P=0.682      (e)          P=0.503      (e)         |P=0.477N     P=0.210      (e)          (e)          |
|POLY 1.5           |     P=0.688      (e)          P=0.501      (e)         |P=0.449N     P=0.223      (e)          (e)          |
|POLY 6             |     P=0.677      (e)          P=0.504      (e)         |P=0.518N     P=0.193      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.741      (e)          P=0.594      (e)         |P=0.388N     P=0.245      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.696      (e)          P=0.505      (e)         |P=0.419N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    3/48 (6%)    35/49 (71%)  45/50 (90%) |0/45 (0%)    0/49 (0%)    10/46 (22%)  10/45 (22%)  |
|POLY-3 ADJUSTED (b)|     0.0%         6.7%         79.2%        91.2%       |0.0%         0.0%         26.2%        28.7%        |
|TERMINAL (d)       |     0/38 (0%)    3/36 (8%)    32/37 (87%)  33/35 (94%) |0/31 (0%)    0/18 (0%)    6/18 (33%)   0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      572          339         |---          ---          619          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.111      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.123      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.120      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.125      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.111      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P=0.002 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.117      P<0.001 **   P<0.001 **  |P<0.001 **   (e)          P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Ectasia                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/49 (27%)  25/48 (52%)  40/49 (82%)  49/50 (98%) |14/45 (31%)  33/49 (67%)  31/46 (67%)  38/45 (84%)  |
|POLY-3 ADJUSTED (b)|     29.2%        54.7%        88.0%        99.1%       |33.7%        78.4%        74.7%        89.8%        |
|TERMINAL (d)       |     11/38 (29%)  21/36 (58%)  34/37 (92%)  35/35 (100%)|12/31 (39%)  18/18 (100%) 17/18 (94%)  2/2 (100%)   |
|FIRST INCIDENCE    |     537          488          486          339         |652          493          465          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.010 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.010 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.012 *    P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.009 **   P<0.001 **   P<0.001 **  |P<0.001 **   P<0.001 **   P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/48 (2%)    15/49 (31%)  20/50 (40%) |0/45 (0%)    1/49 (2%)    5/46 (11%)   2/45 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         33.6%        44.3%       |0.0%         2.7%         13.4%        6.3%         |
|TERMINAL (d)       |     0/38 (0%)    1/36 (3%)    12/37 (32%)  15/35 (43%) |0/31 (0%)    1/18 (6%)    5/18 (28%)   1/2 (50%)    |
|FIRST INCIDENCE    |     ---          730 (T)      486          554         |---          731 (T)      731 (T)      717          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.489      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.392      P=0.005 **   P=0.002 **   |
|POLY 3             |     P<0.001 **   P=0.505      P<0.001 **   P<0.001 **  |P=0.073      P=0.483      P=0.022 *    P=0.185      |
|POLY 1.5           |     P<0.001 **   P=0.502      P<0.001 **   P<0.001 **  |P=0.107      P=0.500      P=0.027 *    P=0.209      |
|POLY 6             |     P<0.001 **   P=0.507      P<0.001 **   P<0.001 **  |P=0.035 *    P=0.460      P=0.017 *    P=0.152      |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.489      P<0.001 **   P<0.001 **  |P<0.001 **   P=0.392      P=0.005 **   P=0.020 *    |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.495      P<0.001 **   P<0.001 **  |P=0.154      P=0.521      P=0.029 *    P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Hyperplasia Atypical                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    1/49 (2%)    2/50 (4%)   |0/45 (0%)    0/49 (0%)    0/46 (0%)    1/45 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.3%         4.6%        |0.0%         0.0%         0.0%         3.1%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    1/37 (3%)    1/35 (3%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          730 (T)      705         |---          ---          ---          626          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.065      (e)          P=0.495      P=0.228     |P=0.169      (e)          (e)          P=0.434      |
|POLY 3             |     P=0.069      (e)          P=0.500      P=0.237     |P=0.171      (e)          (e)          P=0.451      |
|POLY 1.5           |     P=0.070      (e)          P=0.500      P=0.239     |P=0.181      (e)          (e)          P=0.475      |
|POLY 6             |     P=0.067      (e)          P=0.500      P=0.235     |P=0.155      (e)          (e)          P=0.415      |
|LOGISTIC REGRESSION|     P=0.066      (e)          P=0.495      P=0.235     |P=0.213      (e)          (e)          P=0.535      |
|COCH-ARM / FISHERS |     P=0.073      (e)          P=0.500      P=0.253     |P=0.193      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/49 (20%)  11/48 (23%)  25/49 (51%)  33/50 (66%) |17/45 (38%)  21/49 (43%)  12/46 (26%)  14/45 (31%)  |
|POLY-3 ADJUSTED (b)|     23.0%        24.4%        57.2%        71.6%       |40.4%        50.4%        31.3%        39.2%        |
|TERMINAL (d)       |     10/38 (26%)  9/36 (25%)   23/37 (62%)  25/35 (71%) |13/31 (42%)  10/18 (56%)  9/18 (50%)   1/2 (50%)    |
|FIRST INCIDENCE    |     730 (T)      614          639          459         |610          493          465          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.456      P<0.001 **   P<0.001 **  |P=0.003 **   P=0.014 *    P=0.435      P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.538      P<0.001 **   P<0.001 **  |P=0.327N     P=0.237      P=0.268N     P=0.552N     |
|POLY 1.5           |     P<0.001 **   P=0.516      P<0.001 **   P<0.001 **  |P=0.239N     P=0.309      P=0.211N     P=0.440N     |
|POLY 6             |     P<0.001 **   P=0.557      P<0.001 **   P<0.001 **  |P=0.500N     P=0.150      P=0.367N     P=0.462      |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.537      P<0.001 **   P<0.001 **  |P=0.293N     P=0.271      P=0.290N     P=0.466N     |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.479      P<0.001 **   P<0.001 **  |P=0.168N     P=0.386      P=0.166N     P=0.329N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/48 (2%)    1/49 (2%)    4/50 (8%)   |2/45 (4%)    1/49 (2%)    2/46 (4%)    3/45 (7%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         2.3%         9.1%        |4.9%         2.6%         5.3%         9.2%         |
|TERMINAL (d)       |     0/38 (0%)    1/36 (3%)    1/37 (3%)    2/35 (6%)   |1/31 (3%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      730 (T)      512         |728          596          590          596          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.016 *    P=0.489      P=0.495      P=0.059     |P=0.094      P=0.642N     P=0.565      P=0.061      |
|POLY 3             |     P=0.018 *    P=0.505      P=0.500      P=0.062     |P=0.239      P=0.525N     P=0.667      P=0.395      |
|POLY 1.5           |     P=0.018 *    P=0.502      P=0.500      P=0.062     |P=0.268      P=0.498N     P=0.684      P=0.445      |
|POLY 6             |     P=0.017 *    P=0.507      P=0.500      P=0.061     |P=0.195      P=0.562N     P=0.642      P=0.319      |
|LOGISTIC REGRESSION|     P=0.019 *    P=0.489      P=0.495      P=0.067     |P=0.325      P=0.480N     P=0.673N     P=0.410      |
|COCH-ARM / FISHERS |     P=0.019 *    P=0.495      P=0.500      P=0.061     |P=0.299      P=0.468N     P=0.683N     P=0.500      |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    1/49 (2%)    0/50 (0%)   |0/45 (0%)    1/49 (2%)    3/46 (7%)    2/45 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.3%         0.0%        |0.0%         2.6%         7.9%         6.2%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |0/31 (0%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          691          ---         |---          664          582          676          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.687      (e)          P=0.500      (e)         |P=0.073      P=0.412      P=0.091      P=0.141      |
|POLY 3             |     P=0.681      (e)          P=0.500      (e)         |P=0.091      P=0.485      P=0.105      P=0.187      |
|POLY 1.5           |     P=0.686      (e)          P=0.500      (e)         |P=0.119      P=0.500      P=0.114      P=0.210      |
|POLY 6             |     P=0.675      (e)          P=0.501      (e)         |P=0.057      P=0.463      P=0.095      P=0.155      |
|LOGISTIC REGRESSION|     P=0.697      (e)          P=0.500      (e)         |P=0.171      P=0.531      P=0.133      P=0.211      |
|COCH-ARM / FISHERS |     P=0.696      (e)          P=0.500      (e)         |P=0.154      P=0.521      P=0.125      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular: Neuroendocrine Cell                                                                                          |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    0/48 (0%)    0/49 (0%)    4/50 (8%)   |0/45 (0%)    1/49 (2%)    0/46 (0%)    0/45 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         9.2%        |0.0%         2.7%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    3/35 (9%)   |0/31 (0%)    1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          ---          ---          660         |---          731 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.003 **   (e)          (e)          P=0.057     |P=0.823      P=0.392      (e)          (e)          |
|POLY 3             |     P=0.003 **   (e)          (e)          P=0.060     |P=0.599N     P=0.483      (e)          (e)          |
|POLY 1.5           |     P=0.003 **   (e)          (e)          P=0.061     |P=0.585N     P=0.500      (e)          (e)          |
|POLY 6             |     P=0.003 **   (e)          (e)          P=0.059     |P=0.613N     P=0.460      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.003 **   (e)          (e)          P=0.062     |(e)          P=0.392      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.003 **   (e)          (e)          P=0.061     |P=0.569N     P=0.521      (e)          (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 43
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus                                                                                                                           |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/37 (27%)  19/40 (48%)  16/38 (42%)  12/45 (27%) |14/45 (31%)  9/43 (21%)   5/40 (13%)   7/33 (21%)   |
|POLY-3 ADJUSTED (b)|     30.1%        50.5%        48.6%        30.8%       |34.1%        26.9%        15.4%        28.8%        |
|TERMINAL (d)       |     9/29 (31%)   14/28 (50%)  13/26 (50%)  11/31 (36%) |9/27 (33%)   7/15 (47%)   2/15 (13%)   2/2 (100%)   |
|FIRST INCIDENCE    |     583          593          575          569         |632          620          521          676          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.439N     P=0.035 *    P=0.070      P=0.466     |P=0.124      P=0.510      P=0.173N     P=0.029 *    |
|POLY 3             |     P=0.340N     P=0.063      P=0.094      P=0.575     |P=0.238N     P=0.337N     P=0.057N     P=0.432N     |
|POLY 1.5           |     P=0.313N     P=0.058      P=0.098      P=0.590     |P=0.196N     P=0.264N     P=0.045N*    P=0.331N     |
|POLY 6             |     P=0.374N     P=0.066      P=0.091      P=0.555     |P=0.315N     P=0.459N     P=0.074N     P=0.598N     |
|LOGISTIC REGRESSION|     P=0.329N     P=0.056      P=0.090      P=0.566     |P=0.418N     P=0.492N     P=0.053N     P=0.517      |
|COCH-ARM / FISHERS |     P=0.273N     P=0.052      P=0.129      P=0.583N    |P=0.160N     P=0.200N     P=0.035N*    P=0.238N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thymus: Thymocyte                                                                                                                |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/37 (3%)    1/40 (3%)    0/38 (0%)    1/45 (2%)   |0/45 (0%)    2/43 (5%)    3/40 (8%)    0/33 (0%)    |
|POLY-3 ADJUSTED (b)|     3.0%         2.7%         0.0%         2.6%        |0.0%         5.9%         9.0%         0.0%         |
|TERMINAL (d)       |     0/29 (0%)    0/28 (0%)    0/26 (0%)    0/31 (0%)   |0/27 (0%)    0/15 (0%)    0/15 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     580          488          ---          660         |---          620          465          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.624N     P=0.744N     P=0.500N     P=0.758     |P=0.591N     P=0.180      P=0.114      (e)          |
|POLY 3             |     P=0.577N     P=0.739N     P=0.509N     P=0.727N    |P=0.470      P=0.200      P=0.086      (e)          |
|POLY 1.5           |     P=0.574N     P=0.740N     P=0.505N     P=0.723N    |P=0.544      P=0.213      P=0.091      (e)          |
|POLY 6             |     P=0.580N     P=0.742N     P=0.513N     P=0.732N    |P=0.349      P=0.184      P=0.081      (e)          |
|LOGISTIC REGRESSION|     P=0.530N     P=0.655      P=0.439N     P=0.692N    |P=0.594N     P=0.243      P=0.104      (e)          |
|COCH-ARM / FISHERS |     P=0.568N     P=0.733N     P=0.493N     P=0.702N    |P=0.616      P=0.236      P=0.100      (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 44
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland                                                                                                                    |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/49 (0%)    1/50 (2%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    1/46 (2%)    0/46 (0%)    0/42 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.2%         0.0%         6.7%        |0.0%         2.8%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    1/36 (3%)    0/37 (0%)    1/35 (3%)   |0/31 (0%)    1/18 (6%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     ---          730 (T)      ---          339         |---          731 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.043 *    P=0.489      (e)          P=0.119     |P=0.823      P=0.392      (e)          (e)          |
|POLY 3             |     P=0.044 *    P=0.511      (e)          P=0.125     |P=0.617N     P=0.456      (e)          (e)          |
|POLY 1.5           |     P=0.044 *    P=0.509      (e)          P=0.124     |P=0.604N     P=0.469      (e)          (e)          |
|POLY 6             |     P=0.044 *    P=0.511      (e)          P=0.124     |P=0.630N     P=0.437      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.051      P=0.489      (e)          P=0.156     |(e)          P=0.392      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.045 *    P=0.505      (e)          P=0.125     |P=0.589N     P=0.479      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicle                                                                                                          |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    2/50 (4%)    2/50 (4%)    2/50 (4%)   |0/50 (0%)    1/46 (2%)    1/46 (2%)    0/42 (0%)    |
|POLY-3 ADJUSTED (b)|     4.5%         4.3%         4.6%         4.6%        |0.0%         2.8%         2.8%         0.0%         |
|TERMINAL (d)       |     1/38 (3%)    1/36 (3%)    2/37 (5%)    2/35 (6%)   |0/31 (0%)    1/18 (6%)    1/18 (6%)    0/2 (0%)     |
|FIRST INCIDENCE    |     554          614          730 (T)      730 (T)     |---          731 (T)      731 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.572      P=0.684N     P=0.686      P=0.673     |P=0.443      P=0.392      P=0.392      (e)          |
|POLY 3             |     P=0.580      P=0.676N     P=0.689      P=0.689     |P=0.642      P=0.456      P=0.457      (e)          |
|POLY 1.5           |     P=0.588      P=0.679N     P=0.690      P=0.693     |P=0.660N     P=0.469      P=0.469      (e)          |
|POLY 6             |     P=0.571      P=0.676N     P=0.687      P=0.682     |P=0.553      P=0.437      P=0.443      (e)          |
|LOGISTIC REGRESSION|     P=0.592N     P=0.651      P=0.688N     P=0.687N    |(e)          P=0.392      P=0.392      (e)          |
|COCH-ARM / FISHERS |     P=0.590N     P=0.684N     P=0.684N     P=0.684N    |P=0.627N     P=0.479      P=0.479      (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 45
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    7/50 (14%)   6/50 (12%)   5/50 (10%)  |8/50 (16%)   10/46 (22%)  7/46 (15%)   5/42 (12%)   |
|POLY-3 ADJUSTED (b)|     4.5%         15.3%        13.8%        11.4%       |17.9%        27.8%        19.4%        16.8%        |
|TERMINAL (d)       |     1/38 (3%)    7/36 (19%)   6/37 (16%)   3/35 (9%)   |7/31 (23%)   8/18 (44%)   7/18 (39%)   2/2 (100%)   |
|FIRST INCIDENCE    |     537          730 (T)      730 (T)      604         |695          687          731 (T)      681          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.279      P=0.072      P=0.127      P=0.201     |P=0.002 **   P=0.058      P=0.278      P=0.002 **   |
|POLY 3             |     P=0.301      P=0.088      P=0.127      P=0.213     |P=0.433N     P=0.211      P=0.542      P=0.573N     |
|POLY 1.5           |     P=0.310      P=0.087      P=0.129      P=0.217     |P=0.340N     P=0.263      P=0.592      P=0.489N     |
|POLY 6             |     P=0.292      P=0.086      P=0.125      P=0.208     |P=0.501      P=0.150      P=0.477      P=0.540      |
|LOGISTIC REGRESSION|     P=0.302      P=0.091      P=0.134      P=0.227     |P=0.119      P=0.082      P=0.372      P=0.146      |
|COCH-ARM / FISHERS |     P=0.328      P=0.085      P=0.141      P=0.226     |P=0.251N     P=0.323      P=0.571N     P=0.400N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Malformation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     22/23 (96%)  12/13 (92%)  4/4 (100%)   4/5 (80%)   |0/2 (0%)     0/1 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     95.7%        92.3%        100.0%       80.0%       |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     19/20 (95%)  8/9 (89%)    2/2 (100%)   2/3 (67%)   |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     537          488          575          554         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.181N     P=0.626      P=0.527N     P=0.272N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.279N     P=0.629N     P=0.835      P=0.393N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.279N     P=0.629N     P=0.835      P=0.393N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.279N     P=0.629N     P=0.835      P=0.393N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.275N     P=0.598N     P=0.852      P=0.331N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 46
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Infiltration Cellular Lymphocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/49 (12%)   5/50 (10%)   9/50 (18%)   14/50 (28%) |20/50 (40%)  29/49 (59%)  27/47 (57%)  25/46 (54%)  |
|POLY-3 ADJUSTED (b)|     13.5%        10.7%        20.5%        32.1%       |43.5%        66.6%        61.8%        62.9%        |
|TERMINAL (d)       |     4/38 (11%)   3/36 (8%)    8/37 (22%)   12/35 (34%) |15/31 (48%)  14/18 (78%)  13/18 (72%)  1/2 (50%)    |
|FIRST INCIDENCE    |     554          593          575          660         |610          477          465          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.007 **   P=0.492N     P=0.278      P=0.030 *   |P<0.001 **   P<0.001 **   P=0.003 **   P<0.001 **   |
|POLY 3             |     P=0.006 **   P=0.465N     P=0.276      P=0.031 *   |P=0.075      P=0.018 *    P=0.057      P=0.050      |
|POLY 1.5           |     P=0.007 **   P=0.472N     P=0.280      P=0.035 *   |P=0.111      P=0.029 *    P=0.064      P=0.075      |
|POLY 6             |     P=0.005 **   P=0.464N     P=0.271      P=0.027 *   |P=0.040 *    P=0.009 **   P=0.048 *    P=0.027 *    |
|LOGISTIC REGRESSION|     P=0.008 **   P=0.540N     P=0.292      P=0.038 *   |P=0.146      P=0.021 *    P=0.065      P=0.080      |
|COCH-ARM / FISHERS |     P=0.010 *    P=0.486N     P=0.303      P=0.044 *   |P=0.165      P=0.044 *    P=0.065      P=0.114      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |2/50 (4%)    0/49 (0%)    0/47 (0%)    0/46 (0%)    |
|POLY-3 ADJUSTED (b)|     2.3%         0.0%         0.0%         0.0%        |4.5%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/38 (0%)    0/36 (0%)    0/37 (0%)    0/35 (0%)   |1/31 (3%)    0/18 (0%)    0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |     570          ---          ---          ---         |706          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.311N     P=0.483N     P=0.496N     P=0.505N    |P=0.248N     P=0.350N     P=0.345N     P=0.692N     |
|POLY 3             |     P=0.305N     P=0.492N     P=0.503N     P=0.503N    |P=0.108N     P=0.276N     P=0.279N     P=0.319N     |
|POLY 1.5           |     P=0.306N     P=0.493N     P=0.502N     P=0.500N    |P=0.114N     P=0.259N     P=0.265N     P=0.288N     |
|POLY 6             |     P=0.303N     P=0.493N     P=0.504N     P=0.506N    |P=0.099N     P=0.302N     P=0.298N     P=0.372N     |
|LOGISTIC REGRESSION|     P=0.273N     P=0.625N     P=0.438N     P=0.450N    |P=0.183N     P=0.316N     P=0.305N     P=0.476N     |
|COCH-ARM / FISHERS |     P=0.304N     P=0.495N     P=0.495N     P=0.495N    |P=0.124N     P=0.253N     P=0.263N     P=0.269N     |
|=================================================================================================================================|
       Date:  07/20/98                           EXPERIMENT: 05187 TEST: 06                                            Page 47
                     Statistical Analysis of Non-neoplastic Lesions in       Mice(B6C3F1)  -                   METHYLEUGENOL
                                         Terminal Sacrifice at 105 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hydrometra                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |25/50 (50%)  24/50 (48%)  15/49 (31%)  5/47 (11%)   |
|POLY-3 ADJUSTED (b)|                                                        |53.4%        56.3%        36.3%        14.5%        |
|TERMINAL (d)       |                                                        |15/31 (48%)  12/18 (67%)  4/18 (22%)   0/2 (0%)     |
|FIRST INCIDENCE    |                                                        |564          516          521          505          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.215N     P=0.067      P=0.437N     P=0.493N     |
|POLY 3             |                                                        |P<0.001N**   P=0.476      P=0.076N     P<0.001N**   |
|POLY 1.5           |                                                        |P<0.001N**   P=0.570      P=0.055N     P<0.001N**   |
|POLY 6             |                                                        |P<0.001N**   P=0.345      P=0.110N     P<0.001N**   |
|LOGISTIC REGRESSION|                                                        |P<0.001N**   P=0.468      P=0.065N     P<0.001N**   |
|COCH-ARM / FISHERS |                                                        |P<0.001N**   P=0.500N     P=0.039N*    P<0.001N**   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     0 MG/KG      37 MG/KG     75 MG/KG     150         |0 MG/KG      37 MG/KG     75 MG/KG     150          |
|                   |                                            MG/KG       |                                       MG/KG        |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Hyperplasia Cystic                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES       |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |19/50 (38%)  10/50 (20%)  0/49 (0%)    2/47 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |41.6%        24.2%        0.0%         6.0%         |
|TERMINAL (d)       |                                                        |15/31 (48%)  3/18 (17%)   0/18 (0%)    0/2 (0%)     |
|FIRST INCIDENCE    |                                                        |630          477          ---          477          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.004N**   P=0.347N     P<0.001N**   P=0.328N     |
|POLY 3             |                                                        |P<0.001N**   P=0.062N     P<0.001N**   P<0.001N**   |
|POLY 1.5           |                                                        |P<0.001N**   P=0.047N*    P<0.001N**   P<0.001N**   |
|POLY 6             |                                                        |P<0.001N**   P=0.096N     P<0.001N**   P<0.001N**   |
|LOGISTIC REGRESSION|                                                        |P<0.001N**   P=0.053N     P<0.001N**   P<0.001N**   |
|COCH-ARM / FISHERS |                                                        |P<0.001N**   P=0.038N*    P<0.001N**   P<0.001N**   |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).