Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
https://ntp.niehs.nih.gov/go/4592

TDMS Study 05187-09 Pathology Tables

NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98
Route: GAVAGE                                                                                                     Time: 08:39:26

                                                          27 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-15-2

       Lock Date:  09/17/96

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     08/09/94 - 08/10/94

       Treatment Groups:       Include 002    0 MG/KG
                               Include 010    300     MG/KG
                               Include 001    0 MG/KG
                               Include 009    300     MG/KG































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:39:26  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60                                                               


  Scheduled Sacrifice                                  5            5                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                     5            5                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (5)          (5)                                                              
      Basophilic Focus                                              2 (40%)                                                         
      Clear Cell Focus                                              2 (40%)                                                         
      Hepatodiaphragmatic Nodule                       1 (20%)      2 (40%)                                                         
      Mixed Cell Focus                                              3 (60%)                                                         
      Hepatocyte, Hypertrophy                                       5 (100%)                                                        
      Oval Cell, Hyperplasia                                        5 (100%)                                                        
   Pancreas                                           (5)          (5)                                                              
      Acinus, Atrophy                                  1 (20%)      1 (20%)                                                         
   Salivary Glands                                    (5)          (5)                                                              
      Submandibular Gland, Cytoplasmic Alteration                   5 (100%)                                                        
   Stomach, Glandular                                 (5)          (5)                                                              
      Atrophy                                                       5 (100%)                                                        
      Neuroendocrine Cell, Hyperplasia                              1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Islets, Pancreatic                                 (5)          (5)                                                              
      Hyperplasia                                      1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:39:26  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (5)          (5)                                                              
      Cyst                                             1 (20%)                                                                      
   Uterus                                             (5)          (5)                                                              
      Hyperplasia, Cystic                                           1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (5)          (5)                                                              
      Hyperplasia                                                   4 (80%)                                                         
   Lymph Node                                         (1)                                                                           
      Erythrophagocytosis                              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (5)          (5)                                                              
      Inflammation, Granulomatous                                   1 (20%)                                                         
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:39:26  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60                                                               


  Scheduled Sacrifice                                  5            5                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                     5            5                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (5)          (5)                                                              
      Parasite Metazoan                                1 (20%)                                                                      
   Liver                                              (5)          (5)                                                              
      Basophilic Focus                                              3 (60%)                                                         
      Eosinophilic Focus                                            3 (60%)                                                         
      Hepatodiaphragmatic Nodule                       1 (20%)                                                                      
      Mixed Cell Focus                                              5 (100%)                                                        
      Hepatocyte, Hypertrophy                                       5 (100%)                                                        
      Oval Cell, Hyperplasia                                        5 (100%)                                                        
   Pancreas                                           (5)          (5)                                                              
      Acinus, Atrophy                                  1 (20%)      2 (40%)                                                         
      Duct, Hyperplasia                                             1 (20%)                                                         
   Salivary Glands                                    (5)          (5)                                                              
      Submandibular Gland, Cytoplasmic Alteration                   5 (100%)                                                        
   Stomach, Glandular                                 (5)          (5)                                                              
      Atrophy                                                       5 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (5)          (5)                                                              
      Myocardium, Degeneration                         3 (60%)      2 (40%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Islets, Pancreatic                                 (5)          (5)                                                              
      Hyperplasia                                      1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:39:26  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (5)          (5)                                                              
      Inflammation, Chronic                                         1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (5)          (5)                                                              
      Hyperplasia                                                   1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (5)          (5)                                                              
      Nephropathy                                      4 (80%)      5 (100%)                                                        
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------