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TDMS Study 05187-09 Pathology Tables

NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98
Route: GAVAGE                                                                                                     Time: 08:46:24

                                                          52 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-15-2

       Lock Date:  09/17/96

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     02/02/95 - 02/03/95

       Treatment Groups:       Include 002    0 MG/KG
                               Include 010    300     MG/KG
                               Include 001    0 MG/KG
                               Include 009    300     MG/KG































a  Number of animals examined microscopically at site and number of animals with lesion

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NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60                                                               


  Scheduled Sacrifice                                  5            5                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                     5            5                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (5)          (5)                                                              
      Parasite Metazoan                                1 (20%)                                                                      
   Liver                                              (5)          (5)                                                              
      Basophilic Focus                                 5 (100%)     3 (60%)                                                         
      Clear Cell Focus                                 1 (20%)      2 (40%)                                                         
      Eosinophilic Focus                                            3 (60%)                                                         
      Hepatodiaphragmatic Nodule                       2 (40%)                                                                      
      Mixed Cell Focus                                              5 (100%)                                                        
      Bile Duct, Cyst                                               1 (20%)                                                         
      Hepatocyte, Hypertrophy                                       5 (100%)                                                        
      Oval Cell, Hyperplasia                                        5 (100%)                                                        
   Salivary Glands                                    (5)          (5)                                                              
      Submandibular Gland, Cytoplasmic Alteration                   5 (100%)                                                        
   Stomach, Glandular                                 (5)          (5)                                                              
      Atrophy                                                       5 (100%)                                                        
      Neuroendocrine Cell, Hyperplasia                              1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (5)          (5)                                                              
      Myocardium, Degeneration                         2 (40%)      1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Pituitary Gland                                    (5)          (5)                                                              
      Cyst                                                          1 (20%)                                                         
      Pars Distalis, Hyperplasia                                    1 (20%)                                                         
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (5)          (5)                                                              
      Cyst                                                          1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (5)          (5)                                                              
      Dilatation                                       3 (60%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (5)          (5)                                                              
      Nephropathy                                      4 (80%)      2 (40%)                                                         
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          60           60                                                               


  Scheduled Sacrifice                                  5            5                                                               
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         

  Animals Examined Microscopically                     5            5                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (5)          (5)                                                              
      Parasite Metazoan                                1 (20%)      1 (20%)                                                         
   Liver                                              (5)          (5)                                                              
      Basophilic Focus                                 1 (20%)      3 (60%)                                                         
      Clear Cell Focus                                 1 (20%)      1 (20%)                                                         
      Degeneration, Cystic, Focal                                   5 (100%)                                                        
      Eosinophilic Focus                                            5 (100%)                                                        
      Hepatodiaphragmatic Nodule                                    1 (20%)                                                         
      Mixed Cell Focus                                              5 (100%)                                                        
      Bile Duct, Hyperplasia                                        1 (20%)                                                         
      Bile Duct, Hyperplasia, Atypical, Focal                       1 (20%)                                                         
      Hepatocyte, Hypertrophy                                       5 (100%)                                                        
      Oval Cell, Hyperplasia                                        5 (100%)                                                        
   Salivary Glands                                    (5)          (5)                                                              
      Submandibular Gland, Cytoplasmic Alteration                   5 (100%)                                                        
   Stomach, Glandular                                 (5)          (5)                                                              
      Atrophy                                                       5 (100%)                                                        
      Neuroendocrine Cell, Hyperplasia                              2 (40%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (5)          (5)                                                              
      Myocardium, Degeneration                         4 (80%)      3 (60%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Islets, Pancreatic                                 (5)          (5)                                                              
      Hyperplasia                                      2 (40%)                                                                      
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Testes                                             (5)          (5)                                                              
      Interstitial Cell, Hyperplasia                   1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (5)          (5)                                                              
      Hyperplasia                                      1 (20%)      5 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (5)          (5)                                                              
      Inflammation, Granulomatous                                   1 (20%)                                                         
      Alveolar Epithelium, Hypertrophy, Focal          1 (20%)                                                                      
   Nose                                               (5)          (5)                                                              
      Inflammation, Suppurative                                     1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                                                           
      Cataract                                         1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05187-09         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:46:24  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 MG/KG      300                                                                 
                                                                MG/KG                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (5)          (5)                                                              
      Nephropathy                                      5 (100%)     5 (100%)                                                        
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
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                             ----------              END OF REPORT             ----------                                           
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