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TDMS Study 05187-09 Pathology Tables

NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98
Route: GAVAGE                                                                                                     Time: 08:53:18

                                                          52 WEEK SSAC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-15-2

       Lock Date:  09/17/96

       Cage Range:  All

       Reasons For Removal:    25017 Scheduled Sacrifice

       Removal Date Range:     02/02/95 - 02/03/95

       Treatment Groups:       Include 002    0 MG/KG
                               Include 010    300     MG/KG
                               Include 001    0 MG/KG
                               Include 009    300     MG/KG

































                                                              Page   1



NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:53:18  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 1| 1| 1| 1| 1|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 3| 3|                                                           |      A     |
    0 MG/KG                                | 7| 8| 9| 0| 2|                                                           |      L     |
                                           | 7| 7| 3| 4| 9|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |
      Parasite Metazoan                    |             X                                                            |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Basophilic Focus                     | X  X  X  X  X                                                            |      5     |
      Clear Cell Focus                     |             X                                                            |      1     |
      Hepatodiaphragmatic Nodule           | X        X                                                               |      2     |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
      Myocardium, Degeneration             | 1  1                                                                     |      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  +                                                            |   3        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:53:18  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 1| 1| 1| 1| 1|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 3| 3|                                                           |      A     |
    0 MG/KG                                | 7| 8| 9| 0| 2|                                                           |      L     |
                                           | 7| 7| 3| 4| 9|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |
      Dilatation                           |       1  1  2                                                            |      3  1.3|

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          | 1  1  1  1                                                               |      4  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:53:18  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 1| 1| 1| 1| 1|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5|                                                           |      A     |
    300                                    | 0| 0| 2| 2| 3|                                                           |      L     |
    MG/KG                                  | 0| 7| 6| 8| 7|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Basophilic Focus                     | X     X  X                                                               |      3     |
      Clear Cell Focus                     | X     X                                                                  |      2     |
      Eosinophilic Focus                   | X  X  X                                                                  |      3     |
      Mixed Cell Focus                     | X  X  X  X  X                                                            |      5     |
      Bile Duct, Cyst                      | 3                                                                        |      1  3.0|
      Hepatocyte, Hypertrophy              | 3  3  3  3  3                                                            |      5  3.0|
      Oval Cell, Hyperplasia               | 2  2  2  2  1                                                            |      5  1.8|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       | 2  2  2  2  2                                                            |      5  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 3  3  3  3  3                                                            |      5  3.0|
      Neuroendocrine Cell, Hyperplasia     |             1                                                            |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
      Myocardium, Degeneration             |       1                                                                  |      1  1.0|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  M  M                                                            |   2        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |
      Cyst                                 |       3                                                                  |      1  3.0|
      Pars Distalis, Hyperplasia           |          1                                                               |      1  1.0|

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        

                                                             Page   4                                                               
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:53:18  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 1| 1| 1| 1| 1|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5|                                                           |      A     |
    300                                    | 0| 0| 2| 2| 3|                                                           |      L     |
    MG/KG                                  | 0| 7| 6| 8| 7|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +  +                                                            |   4        |

                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |   5        |
      Cyst                                 | 3                                                                        |      1  3.0|

                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          |       1     1                                                            |      2  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:53:18  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 1| 1| 1| 1| 1|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 MG/KG                                | 2| 3| 4| 5| 5|                                                           |      L     |
                                           | 3| 0| 5| 2| 6|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
      Parasite Metazoan                    | X                                                                        |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Basophilic Focus                     |    X                                                                     |      1     |
      Clear Cell Focus                     |             X                                                            |      1     |

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
      Myocardium, Degeneration             | 1     2  2  2                                                            |      4  1.8|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |
      Hyperplasia                          |       1  1                                                               |      2  1.0|

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M                                                            |   4        |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:53:18  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 1| 1| 1| 1| 1|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0|                                                           |      A     |
    0 MG/KG                                | 2| 3| 4| 5| 5|                                                           |      L     |
                                           | 3| 0| 5| 2| 6|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       |    4                                                                     |      1  4.0|

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
      Hyperplasia                          |             1                                                            |      1  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
      Alveolar Epithelium, Hypertrophy,    |                                                                          |            |
           Focal                           |             1                                                            |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Eye                                     |             +                                                            |   1        |
      Cataract                             |             3                                                            |      1  3.0|

 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          | 1  1  1  1  1                                                            |      5  1.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:53:18  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 1| 1| 1| 1| 1|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    300                                    | 2| 4| 4| 5| 5|                                                           |      L     |
    MG/KG                                  | 7| 0| 7| 1| 4|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |   5        |
      Parasite Metazoan                    |       X                                                                  |      1     |

                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |   5        |
      Basophilic Focus                     | X     X  X                                                               |      3     |
      Clear Cell Focus                     |          X                                                               |      1     |
      Degeneration, Cystic, Focal          | 1  1  1  1  1                                                            |      5  1.0|
      Eosinophilic Focus                   | X  X  X  X  X                                                            |      5     |
      Hepatodiaphragmatic Nodule           |             X                                                            |      1     |
      Mixed Cell Focus                     | X  X  X  X  X                                                            |      5     |
      Bile Duct, Hyperplasia, Atypical,    |                                                                          |            |
           Focal                           |       4                                                                  |      1  4.0|
      Bile Duct, Hyperplasia               |    1                                                                     |      1  1.0|
      Hepatocyte, Hypertrophy              | 3  3  3  3  3                                                            |      5  3.0|
      Oval Cell, Hyperplasia               | 1  2  1  1  2                                                            |      5  1.4|

                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |   5        |
      Submandibular Gland, Cytoplasmic     |                                                                          |            |
          Alteration                       | 2  2  2  2  2                                                            |      5  2.0|

                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |   5        |
      Atrophy                              | 1  2  2  2  3                                                            |      5  2.0|
      Neuroendocrine Cell, Hyperplasia     |    1        1                                                            |      2  1.0|

 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |   5        |
      Myocardium, Degeneration             |       2  2  1                                                            |      3  1.7|

 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:53:18  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 1| 1| 1| 1| 1|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    300                                    | 2| 4| 4| 5| 5|                                                           |      L     |
    MG/KG                                  | 7| 0| 7| 1| 4|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |   5        |
      Hyperplasia                          | 1  1  1  1  1                                                            |      5  1.0|

                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M                                                            |   4        |

 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |   5        |

                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |   5        |
      Inflammation, Granulomatous          |    1                                                                     |      1  1.0|

                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |   5        |
      Inflammation, Suppurative            |             2                                                            |      1  2.0|

                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |   5        |

 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        


                                                             Page   9                                                               
NTP Experiment-Test: 05187-09                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 07/20/98  
Route: GAVAGE                                                                                                     Time: 08:53:18  
                                                                                                                                    

 __________________________________________________________________________________________________________________________________ 
                                           | 3| 3| 3| 3| 3|                                                           |            |
                             DAY ON TEST   | 6| 6| 6| 6| 6|                                                           |            |
                                           | 1| 1| 1| 1| 1|                                                           |      T (*) |

 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0|                                                           |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0|                                                           |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2|                                                           |      A     |
    300                                    | 2| 4| 4| 5| 5|                                                           |      L     |
    MG/KG                                  | 7| 0| 7| 1| 4|                                                           |            |

 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |

                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |   5        |
      Nephropathy                          | 2  2  2  2  2                                                            |      5  2.0|

                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |   5        |

 __________________________________________________________________________________________________________________________________ 

  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------