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TDMS Study 05187-09 Pathology Tables

NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98
Route: GAVAGE                                                                                                     Time: 08:06:17

                                                         2 YEAR CHRONIC




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  93-15-2

       Lock Date:  09/17/96

       Cage Range:  All

       Reasons For Removal:    25022 Accidently Killed                 25018 Dosing Accident
                               25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1



NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           50           50           50           60                        
  Early Deaths                                                                                                                      
    Natural Death                                     11            9           13           12            9                        
    Moribund Sacrifice                                17           16           14           26           25                        
    Accidently Killed                                                            1                                                  
    Dosing Accident                                                                           1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           25           22           11           16                        

  Animals Examined Microscopically                    50           50           50           50           50                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)         (50)                      
   Intestine Small, Duodenum                          (50)         (50)         (50)         (50)         (50)                      
      Leiomyosarcoma                                   1 (2%)                                                                       
      Neuroendocrine Tumor, Malignant, Metastatic,                                                                                  
           Stomach, Glandular                                                                 1 (2%)                                
   Liver                                              (50)         (50)         (49)         (49)         (50)                      
      Cholangiocarcinoma                                                                                   1 (2%)                   
      Hepatocellular Carcinoma                                                   4 (8%)       6 (12%)     13 (26%)                  
      Hepatocellular Carcinoma, Multiple                                                      2 (4%)       9 (18%)                  
      Hepatocellular Adenoma                           1 (2%)       8 (16%)      6 (12%)     10 (20%)      7 (14%)                  
      Hepatocellular Adenoma, Multiple                                           5 (10%)     23 (47%)     36 (72%)                  
      Hepatocholangiocarcinoma                                                                3 (6%)       7 (14%)                  
      Hepatocholangiocarcinoma, Multiple                                                                   2 (4%)                   
      Hepatocholangioma                                                                                    8 (16%)                  
      Neuroendocrine Tumor, Malignant, Metastatic,                                                                                  
           Stomach, Glandular                                                                 3 (6%)      10 (20%)                  
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Mesentery                                          (6)          (5)          (3)          (3)          (3)                       
   Oral Mucosa                                                                  (1)                       (1)                       
      Squamous Cell Carcinoma                                                    1 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (49)         (50)                      
   Salivary Glands                                    (50)         (48)         (49)         (49)         (50)                      
      Myoepithelioma                                                                          1 (2%)                                
   Stomach, Forestomach                               (50)         (49)         (50)         (50)         (50)                      
      Leiomyosarcoma                                   1 (2%)                                                                       
      Squamous Cell Carcinoma                                                                 1 (2%)       1 (2%)                   
      Squamous Cell Papilloma                                                    1 (2%)       2 (4%)                                
   Stomach, Glandular                                 (50)         (50)         (50)         (48)         (49)                      
      Leiomyosarcoma                                   1 (2%)                                                                       
      Neuroendocrine Tumor, Benign                                              13 (26%)      9 (19%)      5 (10%)                  
NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Neuroendocrine Tumor, Malignant                               1 (2%)      12 (24%)     26 (54%)     36 (73%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (49)         (50)                      
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Schwannoma Benign                                                                                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Medulla                                    (50)         (50)         (50)         (49)         (50)                      
      Pheochromocytoma Malignant                                                              1 (2%)                                
      Pheochromocytoma Benign                          1 (2%)       1 (2%)       2 (4%)       2 (4%)       6 (12%)                  
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                        1 (2%)                                                                       
      Neuroendocrine Tumor, Malignant, Metastatic,                                                                                  
           Stomach, Glandular                                                                              1 (2%)                   
   Pituitary Gland                                    (50)         (50)         (50)         (50)         (49)                      
      Pars Distalis, Adenoma                          22 (44%)     20 (40%)     21 (42%)     22 (44%)     19 (39%)                  
      Pars Intermedia, Adenoma                                      1 (2%)                                                          
   Thyroid Gland                                      (50)         (49)         (49)         (50)         (48)                      
      C-Cell, Adenoma                                  2 (4%)       4 (8%)       2 (4%)                    2 (4%)                   
      C-Cell, Carcinoma                                             1 (2%)       2 (4%)       2 (4%)       2 (4%)                   
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       1 (2%)       1 (2%)       1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (46)         (49)         (46)         (48)                      
      Adenoma                                          4 (8%)       6 (13%)      4 (8%)       3 (7%)       2 (4%)                   
      Carcinoma                                        1 (2%)                    1 (2%)                                             
      Bilateral, Adenoma                               1 (2%)       2 (4%)       2 (4%)                    2 (4%)                   
   Ovary                                              (50)         (50)         (49)         (49)         (50)                      
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Granulosa Cell Tumor Malignant                                2 (4%)                                                          
   Uterus                                             (50)         (50)         (49)         (50)         (50)                      
      Carcinoma                                                     1 (2%)                                                          
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Polyp Stromal                                    4 (8%)       2 (4%)       3 (6%)       6 (12%)     10 (20%)                  
      Sarcoma Stromal                                               1 (2%)                                                          
   Vagina                                                          (2)                       (2)                                    
      Fibrosarcoma                                                  1 (50%)                                                         
      Leiomyosarcoma                                                                          1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)         (50)                      
   Lymph Node                                         (2)          (5)          (1)          (10)         (6)                       
      Mediastinal, Carcinoma, Metastatic, Uterus                    1 (20%)                                                         
      Mediastinal, Neuroendocrine Tumor, Malignant,                                                                                 
           Metastatic, Stomach, Glandular                                                                  1 (17%)                  
      Pancreatic, Neuroendocrine Tumor, Malignant,                                                                                  
           Metastatic, Stomach, Glandular                                                     1 (10%)                               
      Renal, Neuroendocrine Tumor, Malignant,                                                                                       
          Metastatic, Stomach, Glandular                                                                   1 (17%)                  
   Lymph Node, Mandibular                             (49)         (48)         (49)         (49)         (48)                      
   Lymph Node, Mesenteric                             (50)         (49)         (49)         (49)         (50)                      
   Spleen                                             (50)         (50)         (50)         (49)         (50)                      
      Leiomyosarcoma                                                1 (2%)                    1 (2%)                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Thymus                                             (49)         (48)         (46)         (46)         (49)                      
      Thymoma Benign                                                                          1 (2%)                                
      Thymoma Malignant                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                                                                 1 (2%)       1 (2%)                   
      Carcinoma                                        2 (4%)       3 (6%)       1 (2%)                    4 (8%)                   
      Carcinoma, Multiple                                           1 (2%)                                                          
      Fibroadenoma                                    21 (42%)     23 (46%)     22 (44%)     22 (44%)     16 (32%)                  
      Fibroadenoma, Multiple                          15 (30%)     13 (26%)     12 (24%)      9 (18%)     14 (28%)                  
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Basal Cell Adenoma                                            1 (2%)                                                          
      Basal Cell Carcinoma                                                                                 1 (2%)                   
      Fibrosarcoma                                                                                         1 (2%)                   
      Trichoepithelioma                                             1 (2%)                                                          
      Pinna, Basal Cell Adenoma                                                  1 (2%)                                             
      Pinna, Melanoma Malignant                                                  1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)                    2 (4%)       2 (4%)       1 (2%)                   
      Subcutaneous Tissue, Fibrosarcoma                                          2 (4%)                                             
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Sarcoma NOS                                                                     1 (2%)                   
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Chordoma                                                                                             1 (2%)                   
   Skeletal Muscle                                                 (1)                       (1)          (1)                       
      Carcinoma, Metastatic, Uterus                                 1 (100%)                                                        
      Rhabdomyosarcoma                                                                        1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Oligodendroglioma Benign                                                                1 (2%)                                
      Oligodendroglioma Malignant                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (49)         (49)         (50)                      
      Alveolar/Bronchiolar Adenoma                                               1 (2%)                    1 (2%)                   
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                                                       
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
      Carcinoma, Metastatic, Zymbal's Gland                                                                1 (2%)                   
      Chordoma, Metastatic, Bone                                                                           1 (2%)                   
      Hepatocellular Carcinoma, Metastatic, Liver                                1 (2%)       4 (8%)       4 (8%)                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                                          1 (2%)                   
      Neuroendocrine Tumor, Malignant, Metastatic,                                                                                  
           Stomach, Glandular                                                                              4 (8%)                   
      Squamous Cell Carcinoma, Metastatic, Oral                                                                                     
          Mucosa                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                                            (1)          (3)                       
      Carcinoma                                                                                            3 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (49)         (50)                      
      Transitional Epithelium, Carcinoma                                                                   1 (2%)                   
   Urinary Bladder                                    (50)         (50)         (49)         (50)         (50)                      
      Carcinoma, Metastatic, Uterus                                 1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)                      
      Leukemia Mononuclear                            17 (34%)     20 (40%)     19 (38%)     28 (56%)     17 (34%)                  
      Mesothelioma Malignant                                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page   6                                                               
NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          49          48          47          47                           
     Total Primary Neoplasms                          100         121         141         187         232                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          44          43          43          46                           
     Total Benign Neoplasms                            73          86          85         106         127                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              22          28          26          34          39                           
     Total Malignant Neoplasms                         27          34          31          46          64                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          1           3           8          16                           
     Total Metastatic Neoplasm                                      6           4           9          24                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1          25          35          41                           
     Total Uncertain Neoplasms                                      1          25          35          41                           
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          60           50           50           50           60                        
  Early Deaths                                                                                                                      
    Natural Death                                     15           15           17           29           26                        
    Moribund Sacrifice                                15           18           15           20           23                        
    Dosing Accident                                                 1            3            1            1                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           16           15                                                  

  Animals Examined Microscopically                    50           50           50           50           50                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (50)         (50)         (50)         (50)         (49)                      
   Intestine Small, Jejunum                           (50)         (50)         (50)         (50)         (50)                      
      Polyp Adenomatous                                1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)         (50)                      
      Carcinoma, Metastatic, Pancreas                                                                      1 (2%)                   
      Cholangioma                                                                                          2 (4%)                   
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Hepatocellular Carcinoma                         2 (4%)       3 (6%)      13 (26%)     14 (28%)     13 (26%)                  
      Hepatocellular Carcinoma, Multiple                                         1 (2%)      11 (22%)     23 (46%)                  
      Hepatocellular Adenoma                           5 (10%)      7 (14%)      9 (18%)     14 (28%)      8 (16%)                  
      Hepatocellular Adenoma, Multiple                              5 (10%)     14 (28%)     24 (48%)     24 (48%)                  
      Hepatocholangiocarcinoma                                                   1 (2%)       1 (2%)       6 (12%)                  
      Hepatocholangiocarcinoma, Multiple                                                                   1 (2%)                   
      Hepatocholangioma                                                                       1 (2%)       3 (6%)                   
      Hepatocholangioma, Multiple                                                                          3 (6%)                   
      Ito Cell Tumor Benign                                                                                1 (2%)                   
      Interstitial Cell, Carcinoma, Metastatic,                                                                                     
           Testes                                                                                          1 (2%)                   
   Mesentery                                          (5)          (6)                       (1)          (1)                       
      Hepatocellular Carcinoma, Metastatic, Liver                                                          1 (100%)                 
      Leiomyosarcoma                                                                          1 (100%)                              
   Oral Mucosa                                                                               (1)                                    
      Pharyngeal, Squamous Cell Papilloma                                                     1 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)         (49)                      
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Carcinoma                                                                                            1 (2%)                   
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)       1 (2%)                   
      Leiomyosarcoma, Metastatic, Mesentery                                                   1 (2%)                                
   Salivary Glands                                    (50)         (50)         (50)         (48)         (48)                      
      Schwannoma Malignant                             1 (2%)                                                                       
   Stomach, Forestomach                               (50)         (50)         (50)         (50)         (49)                      
      Squamous Cell Carcinoma                                                                              1 (2%)                   
NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                                       1 (2%)                                                          
   Stomach, Glandular                                 (50)         (50)         (50)         (50)         (49)                      
      Neuroendocrine Tumor, Benign                                                            3 (6%)       2 (4%)                   
      Neuroendocrine Tumor, Malignant                                                         4 (8%)       2 (4%)                   
   Tongue                                                          (2)                       (1)                                    
      Squamous Cell Papilloma                                       2 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (49)                      
      Endocardium, Schwannoma Malignant                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)         (50)                      
      Adenoma                                                       1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                                          1 (2%)                   
   Adrenal Medulla                                    (50)         (50)         (50)         (50)         (50)                      
      Pheochromocytoma Malignant                       1 (2%)                    1 (2%)       1 (2%)                                
      Pheochromocytoma Benign                         18 (36%)     12 (24%)      8 (16%)      8 (16%)      9 (18%)                  
      Bilateral, Pheochromocytoma Benign               6 (12%)      5 (10%)      3 (6%)       2 (4%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)         (49)                      
      Adenoma                                          3 (6%)       1 (2%)                                                          
   Parathyroid Gland                                  (48)         (49)         (48)         (45)         (46)                      
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (50)         (50)         (50)                      
      Oligodendroglioma Malignant, Metastatic,                                                                                      
           Brain                                                                 1 (2%)                                             
      Pars Distalis, Adenoma                           7 (14%)      8 (16%)      8 (16%)      2 (4%)       3 (6%)                   
   Thyroid Gland                                      (50)         (50)         (50)         (48)         (48)                      
      C-Cell, Adenoma                                  6 (12%)      4 (8%)       2 (4%)       3 (6%)       1 (2%)                   
      Follicular Cell, Adenoma                         2 (4%)       1 (2%)       1 (2%)       1 (2%)       3 (6%)                   
      Follicular Cell, Carcinoma                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)          (1)          (2)          (6)          (2)                       
      Squamous Cell Carcinoma, Metastatic, Ureter                                                          1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (49)         (49)         (50)         (50)                      
      Squamous Cell Carcinoma, Metastatic, Ureter                                                          1 (2%)                   
   Preputial Gland                                    (50)         (50)         (49)         (50)         (50)                      
      Adenoma                                          8 (16%)     12 (24%)      3 (6%)       7 (14%)      4 (8%)                   
      Carcinoma                                        5 (10%)      1 (2%)       2 (4%)                                             
      Bilateral, Adenoma                               1 (2%)       4 (8%)                    1 (2%)       2 (4%)                   
   Prostate                                           (50)         (50)         (49)         (49)         (49)                      
      Carcinoma                                                                               1 (2%)                                
      Leiomyosarcoma, Metastatic, Mesentery                                                   1 (2%)                                
   Seminal Vesicle                                    (50)         (50)         (50)         (50)         (50)                      
      Leiomyosarcoma, Metastatic, Mesentery                                                   1 (2%)                                
      Squamous Cell Carcinoma, Metastatic, Ureter                                                          1 (2%)                   
   Testes                                             (50)         (49)         (49)         (50)         (50)                      
      Squamous Cell Carcinoma, Metastatic, Ureter                                                          1 (2%)                   
      Bilateral, Interstitial Cell, Adenoma           45 (90%)     46 (94%)     48 (98%)     46 (92%)     41 (82%)                  
      Interstitial Cell, Adenoma                       1 (2%)       2 (4%)                    4 (8%)       2 (4%)                   
      Interstitial Cell, Carcinoma                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Lymph Node                                         (8)          (4)          (4)          (4)          (3)                       
      Lumbar, Carcinoma, Metastatic, Preputial                                                                                      
          Gland                                        1 (13%)                                                                      
      Lumbar, Fibrous Histiocytoma, Metastatic,                                                                                     
           Skin                                                     1 (25%)                                                         
      Mediastinal, Carcinoma, Metastatic, Pancreas                                                         1 (33%)                  
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Skin                                          1 (25%)                                                         
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                                                1 (33%)                  
      Renal, Fibrous Histiocytoma, Metastatic, Skin                 1 (25%)                                                         
   Lymph Node, Mandibular                             (49)         (50)         (50)         (48)         (47)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)         (48)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                                          1 (2%)                   
   Spleen                                             (50)         (50)         (50)         (50)         (49)                      
      Hemangiosarcoma                                                                                      1 (2%)                   
      Leiomyosarcoma                                   1 (2%)                                                                       
   Thymus                                             (46)         (45)         (43)         (42)         (43)                      
      Thymoma Benign                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (49)         (45)         (46)                      
      Adenoma, Multiple                                                          1 (2%)                                             
      Carcinoma                                        1 (2%)                    2 (4%)                                             
      Fibroadenoma                                     5 (10%)      5 (10%)     10 (20%)     10 (22%)      6 (13%)                  
      Fibroadenoma, Multiple                                                     5 (10%)      3 (7%)                                
   Skin                                               (50)         (50)         (50)         (50)         (50)                      
      Basal Cell Carcinoma                                          1 (2%)                                                          
      Keratoacanthoma                                  3 (6%)       3 (6%)       4 (8%)       5 (10%)      2 (4%)                   
      Squamous Cell Papilloma                                                                 1 (2%)       1 (2%)                   
      Pinna, Melanoma Malignant                                     1 (2%)       1 (2%)                    1 (2%)                   
      Subcutaneous Tissue, Fibroma                     1 (2%)       8 (16%)      6 (12%)      5 (10%)      4 (8%)                   
      Subcutaneous Tissue, Fibroma, Multiple                        1 (2%)       2 (4%)                                             
      Subcutaneous Tissue, Fibrosarcoma                             2 (4%)                    2 (4%)                                
      Subcutaneous Tissue, Fibrosarcoma, Multiple                   1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Fibrous Histiocytoma                     1 (2%)                                                          
      Subcutaneous Tissue, Hemangioma, Multiple                                  1 (2%)                                             
      Subcutaneous Tissue, Lipoma                                                                          1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)                      
      Osteosarcoma                                     1 (2%)                                                                       
   Skeletal Muscle                                                 (1)                                                              
      Sarcoma NOS                                                   1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)                      
      Oligodendroglioma Benign                                      1 (2%)                                                          
      Oligodendroglioma Malignant                      1 (2%)       1 (2%)       1 (2%)                                             
   Spinal Cord                                        (1)          (1)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (49)                      
      Alveolar/Bronchiolar Adenoma                                  1 (2%)                    1 (2%)                                
      Chordoma, Metastatic, Uncertain Primary Site                                                         1 (2%)                   
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)       2 (4%)      10 (20%)     22 (45%)                  
      Hepatocholangiocarcinoma, Metastatic, Liver                                1 (2%)                    1 (2%)                   
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                              1 (2%)                                                                       
      Squamous Cell Carcinoma, Metastatic, Ureter                                                          1 (2%)                   
NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - cont                                                                                                           
      Mediastinum, Osteosarcoma, Metastatic, Bone      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (2)                       (1)          (1)                       
      Carcinoma                                        1 (100%)     2 (100%)                  1 (100%)     1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)         (50)                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                                                          1 (2%)                   
      Mesenchymal Tumor Benign                         1 (2%)                                                                       
      Bilateral, Renal Tubule, Adenoma                                           1 (2%)                                             
      Renal Tubule, Adenoma                            3 (6%)       2 (4%)       5 (10%)      6 (12%)      8 (16%)                  
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
      Renal Tubule, Oncocytoma Benign                                            1 (2%)                    1 (2%)                   
   Ureter                                                                                                 (1)                       
      Squamous Cell Carcinoma                                                                              1 (100%)                 
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)                      
      Leukemia Mononuclear                            26 (52%)     27 (54%)     15 (30%)     13 (26%)      1 (2%)                   
      Mesothelioma Malignant                           1 (2%)       3 (6%)       5 (10%)     12 (24%)      5 (10%)                  
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 


                                                             Page  12                                                               
NTP Experiment-Test: 05187-09  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                           METHYLEUGENOL                                       Date: 09/15/98  
Route: GAVAGE                                                                                                     Time: 08:06:17  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 MG/KG      37 MG/KG     75 MG/KG     150          300                          
                                                                                          MG/KG        MG/KG                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          48          50          46                           
     Total Primary Neoplasms                          159         180         176         212         189                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          50          48          50          46                           
     Total Benign Neoplasms                           117         134         133         147         129                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          33          34          39          43                           
     Total Malignant Neoplasms                         42          46          43          58          56                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2           4          11          25                           
     Total Metastatic Neoplasm                          3          10           4          14          38                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                               1                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                      7           4                           
     Total Uncertain Neoplasms                                                              7           4                           
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
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                             ----------              END OF REPORT             ----------                                           
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