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TDMS Study 05188-06 Pathology Tables

NTP Experiment-Test: 05188-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96
Route: SKIN APPLICATION                                                                                           Time: 05:02:39




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  1300-72-7

       Lock Date:  07/28/93

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All




































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05188-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      7           10            9            8                                     
    Moribund Sacrifice                                12            7            9            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           32           32           36                                     
  Missing                                                           1                                                               

  Animals Examined Microscopically                    50           49           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (16)         (18)         (50)                                   
      Inflammation                                                  1 (6%)                                                          
   Intestine Small, Duodenum                          (50)         (17)         (18)         (50)                                   
      Inflammation                                     1 (2%)                                                                       
   Intestine Small, Ileum                             (50)         (17)         (18)         (50)                                   
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (50)         (49)         (50)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                              3 (6%)       2 (4%)       1 (2%)                                
      Clear Cell Focus                                              1 (2%)                                                          
      Eosinophilic Focus                              14 (28%)     11 (22%)     11 (22%)     10 (20%)                               
      Hematopoietic Cell Proliferation                 2 (4%)       2 (4%)       1 (2%)       1 (2%)                                
      Infarct                                                                                 1 (2%)                                
      Inflammation, Chronic Active                    22 (44%)     28 (57%)     24 (48%)     21 (42%)                               
      Mixed Cell Focus                                10 (20%)      3 (6%)       1 (2%)       7 (14%)                               
      Necrosis                                         3 (6%)       4 (8%)       9 (18%)      3 (6%)                                
      Pigmentation, Hemosiderin                        1 (2%)                                 1 (2%)                                
      Bile Duct, Cyst                                  2 (4%)                                                                       
      Bile Duct, Hyperplasia                           4 (8%)       2 (4%)       4 (8%)       2 (4%)                                
      Serosa, Necrosis                                                           1 (2%)                                             
   Mesentery                                          (7)          (6)          (5)          (12)                                   
      Inflammation                                     1 (14%)                   1 (20%)                                            
      Fat, Necrosis                                    3 (43%)      2 (33%)                   7 (58%)                               
   Pancreas                                           (50)         (17)         (18)         (50)                                   
      Atrophy                                          3 (6%)                    1 (6%)       6 (12%)                               
      Cytoplasmic Alteration                           1 (2%)                                 1 (2%)                                
      Inflammation                                     1 (2%)                                                                       
      Necrosis                                                                                1 (2%)                                
      Duct, Cyst                                       2 (4%)       2 (12%)      1 (6%)       5 (10%)                               
   Salivary Glands                                    (50)         (17)         (18)         (50)                                   
      Atrophy                                          1 (2%)                                 1 (2%)                                
      Fibrosis                                                                                1 (2%)                                
   Stomach, Forestomach                               (50)         (17)         (18)         (50)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05188-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Erosion                                                                    1 (6%)                                             
      Hyperplasia, Focal                               1 (2%)       1 (6%)                    3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (17)         (18)         (50)                                   
      Aorta, Inflammation, Chronic Active                                                     1 (2%)                                
   Heart                                              (50)         (17)         (18)         (50)                                   
      Degeneration                                                  2 (12%)                                                         
      Mineralization                                   5 (10%)                                1 (2%)                                
      Atrium, Thrombosis                                                                      1 (2%)                                
      Epicardium, Inflammation, Suppurative                                      1 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (17)         (18)         (50)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Degeneration                                                                            1 (2%)                                
      Hyperplasia                                                                1 (6%)       2 (4%)                                
      Capsule, Hyperplasia, Adenomatous                1 (2%)                                                                       
   Adrenal Medulla                                    (50)         (17)         (18)         (48)                                   
      Hyperplasia                                      3 (6%)                    1 (6%)       3 (6%)                                
   Islets, Pancreatic                                 (50)         (17)         (18)         (50)                                   
      Hyperplasia                                      7 (14%)      1 (6%)       2 (11%)      4 (8%)                                
   Pituitary Gland                                    (50)         (17)         (18)         (49)                                   
      Cyst                                             1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      25 (50%)      6 (35%)     11 (61%)     26 (53%)                               
   Thyroid Gland                                      (50)         (48)         (50)         (50)                                   
      Inflammation                                                               1 (2%)                                             
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                    26 (52%)     19 (40%)     19 (38%)     25 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (17)         (18)         (49)                                   
      Cyst                                            10 (20%)                   2 (11%)     13 (27%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Metaplasia                                       1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05188-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Thrombosis                                                                 1 (6%)                                             
   Oviduct                                                                                   (1)                                    
      Inflammation, Chronic                                                                   1 (100%)                              
   Uterus                                             (50)         (17)         (18)         (50)                                   
      Hemorrhage                                                                 1 (6%)                                             
      Hyperplasia, Cystic                             21 (42%)      2 (12%)      4 (22%)     22 (44%)                               
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Lymphatic, Angiectasis                           1 (2%)                                                                       
      Lymphatic, Cyst                                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (17)         (18)         (50)                                   
      Hyperplasia                                     12 (24%)      1 (6%)       4 (22%)     11 (22%)                               
      Myelofibrosis                                    1 (2%)                                 4 (8%)                                
   Lymph Node                                         (7)          (3)          (6)          (6)                                    
      Mediastinal, Hyperplasia, Lymphoid               1 (14%)                                                                      
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                                          1 (17%)                               
   Lymph Node, Mesenteric                             (48)         (17)         (17)         (50)                                   
      Angiectasis                                      1 (2%)                                 2 (4%)                                
      Hematopoietic Cell Proliferation                 2 (4%)                                                                       
      Hemorrhage                                                    1 (6%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
   Spleen                                             (50)         (17)         (18)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Hematopoietic Cell Proliferation                19 (38%)      8 (47%)     12 (67%)     11 (22%)                               
   Thymus                                             (38)         (16)         (16)         (44)                                   
      Atrophy                                          5 (13%)      7 (44%)      4 (25%)      4 (9%)                                
      Cyst                                                                       1 (6%)                                             
      Hyperplasia, Lymphoid                            2 (5%)       1 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (17)         (16)         (50)                                   
      Hyperplasia                                      5 (10%)      1 (6%)       3 (19%)      6 (12%)                               
   Skin                                               (50)         (49)         (50)         (50)                                   
      Epidermis, Skin, Site of Application, Exudate    1 (2%)       4 (8%)       4 (8%)       1 (2%)                                
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                  4 (8%)       1 (2%)       4 (8%)       4 (8%)                                
      Epidermis, Skin, Site of Application, Ulcer                   1 (2%)       1 (2%)       1 (2%)                                
      Skin, Site of Application, Inflammation,                                                                                      
           Chronic                                     4 (8%)       1 (2%)       1 (2%)       1 (2%)                                
      Skin, Site of Application, Parakeratosis                                   1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05188-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Inflammation, Chronic Active                 1 (2%)       2 (4%)                                             
      Subcutaneous Tissue, Skin, Site of                                                                                            
          Application, Inflammation, Suppurative       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (17)         (18)         (50)                                   
      Inflammation                                                               1 (6%)                                             
      Neuron, Necrosis                                 2 (4%)       1 (6%)       4 (22%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (18)         (18)         (50)                                   
      Hemorrhage                                       1 (2%)                                 1 (2%)                                
      Hyperplasia, Lymphoid                                                                   1 (2%)                                
      Inflammation                                     1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Thrombosis                                                                 1 (6%)                                             
      Alveolar Epithelium, Hyperplasia                 2 (4%)                                 2 (4%)                                
      Bronchiole, Hyperplasia                          1 (2%)                                 1 (2%)                                
   Nose                                               (50)         (17)         (18)         (50)                                   
      Inflammation, Suppurative                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)          (2)                                                              
      Degeneration                                                  1 (50%)                                                         
      Cornea, Inflammation                             1 (100%)                                                                     
   Harderian Gland                                    (5)          (2)          (1)          (3)                                    
      Hyperplasia                                      1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05188-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (17)         (18)         (50)                                   
      Hydronephrosis                                                                          1 (2%)                                
      Infarct                                                                    1 (6%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Nephropathy                                     22 (44%)      1 (6%)       6 (33%)     17 (34%)                               
      Pigmentation                                     2 (4%)                                                                       
      Artery, Inflammation, Chronic Active                                       1 (6%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05188-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                     11           10            3            9                                     
    Moribund Sacrifice                                 7            3            8            6                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                32           37           39           35                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (50)         (12)         (10)         (50)                                   
      Necrosis                                         1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)       2 (4%)                    1 (2%)                                
      Basophilic Focus                                 2 (4%)       6 (12%)      3 (6%)       4 (8%)                                
      Clear Cell Focus                                 4 (8%)       3 (6%)       3 (6%)       8 (16%)                               
      Eosinophilic Focus                              13 (26%)     11 (22%)     12 (24%)      9 (18%)                               
      Hematopoietic Cell Proliferation                 3 (6%)                    1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Infarct                                                                    1 (2%)                                             
      Inflammation, Chronic Active                    46 (92%)     44 (88%)     41 (82%)     43 (86%)                               
      Mixed Cell Focus                                 3 (6%)       4 (8%)       5 (10%)      7 (14%)                               
      Necrosis                                         8 (16%)      5 (10%)      2 (4%)       8 (16%)                               
      Thrombosis                                       1 (2%)                    1 (2%)                                             
      Vacuolization Cytoplasmic                                     2 (4%)       1 (2%)       1 (2%)                                
      Bile Duct, Hyperplasia                          43 (86%)     41 (82%)     36 (72%)     37 (74%)                               
      Kupffer Cell, Pigmentation                       1 (2%)                                                                       
   Mesentery                                          (5)                                    (4)                                    
      Hemorrhage                                                                              1 (25%)                               
      Artery, Inflammation, Chronic Active             1 (20%)                                1 (25%)                               
      Fat, Inflammation                                1 (20%)                                                                      
      Vein, Thrombosis                                 1 (20%)                                1 (25%)                               
   Pancreas                                           (50)         (13)         (11)         (50)                                   
      Atrophy                                          3 (6%)                    1 (9%)       4 (8%)                                
      Cytoplasmic Alteration                           4 (8%)                                                                       
      Necrosis                                         1 (2%)                    1 (9%)                                             
      Artery, Inflammation, Chronic Active             2 (4%)                                                                       
   Salivary Glands                                    (50)         (13)         (11)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Necrosis                                                                   1 (9%)                                             
   Stomach, Forestomach                               (50)         (13)         (11)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Focal                               1 (2%)                    1 (9%)       2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05188-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Ulcer                                            2 (4%)                                                                       
   Stomach, Glandular                                 (50)         (13)         (11)         (50)                                   
      Erosion                                                                                 1 (2%)                                
      Mineralization                                                                          1 (2%)                                
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (50)         (13)         (11)         (50)                                   
      Aorta, Inflammation, Chronic Active              1 (2%)                    1 (9%)       1 (2%)                                
   Heart                                              (50)         (13)         (11)         (50)                                   
      Degeneration                                     2 (4%)       1 (8%)       1 (9%)       1 (2%)                                
      Mineralization                                   1 (2%)                                 2 (4%)                                
      Artery, Inflammation, Chronic Active             1 (2%)                                 1 (2%)                                
      Atrium, Thrombosis                               1 (2%)       1 (8%)       1 (9%)       1 (2%)                                
      Ventricle, Thrombosis                                         1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (12)         (11)         (50)                                   
      Accessory Adrenal Cortical Nodule                2 (4%)                    1 (9%)       1 (2%)                                
      Degeneration, Cystic                                                                    1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Hyperplasia                                     11 (22%)      1 (8%)       1 (9%)      19 (38%)                               
      Inflammation, Chronic Active                                                            1 (2%)                                
      Capsule, Hyperplasia, Adenomatous                                                       4 (8%)                                
   Adrenal Medulla                                    (50)         (12)         (11)         (50)                                   
      Hyperplasia                                      2 (4%)       2 (17%)      1 (9%)       1 (2%)                                
   Islets, Pancreatic                                 (50)         (12)         (11)         (50)                                   
      Hyperplasia                                      9 (18%)                   2 (18%)      9 (18%)                               
   Parathyroid Gland                                  (46)         (9)          (7)          (42)                                   
      Cyst                                                                                    1 (2%)                                
   Pituitary Gland                                    (49)         (12)         (10)         (50)                                   
      Cyst                                             2 (4%)                                 2 (4%)                                
      Pars Distalis, Hyperplasia                       2 (4%)                                 2 (4%)                                
      Pars Intermedia, Hyperplasia                                                            2 (4%)                                
   Thyroid Gland                                      (50)         (13)         (11)         (50)                                   
      Follicular Cell, Hyperplasia                     6 (12%)      2 (15%)                  10 (20%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05188-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (13)         (11)         (50)                                   
      Granuloma Sperm                                  2 (4%)                                 2 (4%)                                
      Artery, Inflammation, Chronic Active                                       1 (9%)       1 (2%)                                
   Preputial Gland                                    (50)         (13)         (10)         (49)                                   
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Duct, Cyst                                       7 (14%)      1 (8%)       4 (40%)      6 (12%)                               
   Prostate                                           (50)         (13)         (11)         (50)                                   
      Degeneration                                                               1 (9%)                                             
      Artery, Inflammation, Chronic Active                                       1 (9%)       1 (2%)                                
   Seminal Vesicle                                    (50)         (13)         (11)         (50)                                   
      Degeneration                                                               1 (9%)                                             
   Testes                                             (50)         (13)         (11)         (50)                                   
      Atrophy                                                                                 2 (4%)                                
      Artery, Inflammation, Chronic Active                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (13)         (11)         (50)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hyperplasia                                     17 (34%)      3 (23%)      4 (36%)     23 (46%)                               
      Infiltration Cellular, Mast Cell                 1 (2%)                                                                       
      Infiltration Cellular, Plasma Cell               1 (2%)                                                                       
      Myelofibrosis                                    1 (2%)                                                                       
      Thrombosis                                                                              1 (2%)                                
   Lymph Node                                         (3)          (2)          (2)          (3)                                    
      Mediastinal, Angiectasis                                                                1 (33%)                               
      Mediastinal, Hematopoietic Cell Proliferation    1 (33%)                                                                      
   Lymph Node, Mesenteric                             (50)         (9)          (10)         (47)                                   
      Angiectasis                                      1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (10%)                                            
      Hyperplasia, Histiocytic                                                                1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                    1 (10%)                                            
      Hyperplasia, Plasma Cell                                                                1 (2%)                                
   Spleen                                             (50)         (13)         (12)         (49)                                   
      Hematopoietic Cell Proliferation                27 (54%)      8 (62%)      8 (67%)     25 (51%)                               
      Lymphoid Follicle, Depletion Cellular                                                   1 (2%)                                
      Lymphoid Follicle, Hyperplasia                   1 (2%)                                                                       
   Thymus                                             (37)         (11)         (6)          (34)                                   
      Atrophy                                          9 (24%)      5 (45%)      2 (33%)      6 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05188-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)         (50)                                   
      Epidermis, Skin, Site of Application, Exudate                 1 (2%)       1 (2%)       1 (2%)                                
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperkeratosis                                                         1 (2%)                                             
      Epidermis, Skin, Site of Application,                                                                                         
          Hyperplasia                                  1 (2%)                    4 (8%)       5 (10%)                               
      Epidermis, Skin, Site of Application, Ulcer                                             1 (2%)                                
      Subcutaneous Tissue, Edema                       1 (2%)                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Inflammation,                                                                                            
          Suppurative                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (13)         (11)         (50)                                   
      Inflammation                                                               1 (9%)                                             
      Artery, Inflammation, Chronic Active                                       1 (9%)                                             
      Corpus Callosum, Degeneration                                                           1 (2%)                                
      Neuron, Necrosis                                              1 (8%)       1 (9%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (16)         (15)         (50)                                   
      Inflammation                                                               1 (7%)                                             
      Pigmentation, Hemosiderin                                                  1 (7%)                                             
      Thrombosis                                                                 1 (7%)                                             
      Alveolar Epithelium, Hyperplasia                              2 (13%)      1 (7%)       2 (4%)                                
      Mediastinum, Angiectasis                         1 (2%)                                                                       
   Nose                                               (50)         (13)         (11)         (50)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (2)                                    
      Inflammation                                                                            1 (50%)                               
   Harderian Gland                                    (2)                       (1)          (3)                                    
      Hyperplasia                                      1 (50%)                                1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05188-06         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       SODIUM XYLENESULFONATE                                  Date: 04/04/96  
Route: SKIN APPLICATION                                                                                           Time: 05:02:39  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          0 MG/KG      182          364          727                                       
                                                                MG/KG        MG/KG        MG/KG                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (13)         (11)         (50)                                   
      Cyst                                             5 (10%)                                8 (16%)                               
      Glomerulosclerosis                               2 (4%)       1 (8%)                    4 (8%)                                
      Hydronephrosis                                                                          1 (2%)                                
      Infarct                                          1 (2%)                                 1 (2%)                                
      Mineralization                                                                          4 (8%)                                
      Nephropathy                                     43 (86%)     10 (77%)      8 (73%)     43 (86%)                               
      Pigmentation, Hemosiderin                        1 (2%)                    1 (9%)       1 (2%)                                
      Artery, Inflammation, Chronic Active                                       1 (9%)       1 (2%)                                
      Glomerulus, Infarct                              1 (2%)                                                                       
      Glomerulus, Thrombosis                                                     1 (9%)                                             
      Renal Tubule, Hyperplasia                                                               1 (2%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
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