TDMS Study 05197-11 Pathology Tables
NTP Experiment-Test: 05197-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-BUTOXYETHANOL Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:42
2 YEAR CHRONIC FINAL#1
Facility: Battelle Northwest
Chemical CAS #: 111-76-0002
Lock Date: 11/08/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05197-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-BUTOXYETHANOL Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 31.2 PPM 62.5 PPM 125 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 18 21 23 26
Natural Death 3 2 4 3
Survivors
Terminal Sacrifice 29 27 23 21
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (50) (50) (49)
Necrosis 1 (2%)
Parasite Metazoan 4 (8%) 5 (10%) 2 (4%) 3 (6%)
Intestine Large, Rectum (44) (47) (48) (47)
Parasite Metazoan 1 (2%) 4 (9%) 3 (6%) 4 (9%)
Intestine Large, Cecum (47) (49) (48) (48)
Inflammation, Chronic 1 (2%)
Parasite Metazoan 8 (17%) 6 (12%) 4 (8%) 5 (10%)
Intestine Small, Ileum (47) (50) (47) (47)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 2 (4%) 2 (4%) 1 (2%)
Basophilic Focus 39 (78%) 41 (82%) 41 (82%) 38 (76%)
Clear Cell Focus 12 (24%) 8 (16%) 5 (10%) 9 (18%)
Degeneration, Cystic 1 (2%)
Eosinophilic Focus 13 (26%) 10 (20%) 6 (12%) 5 (10%)
Fatty Change 11 (22%) 12 (24%) 12 (24%) 6 (12%)
Hematopoietic Cell Proliferation 4 (8%) 5 (10%) 1 (2%)
Hepatodiaphragmatic Nodule 9 (18%) 6 (12%) 3 (6%) 1 (2%)
Inflammation, Granulomatous 1 (2%)
Mixed Cell Focus 6 (12%) 2 (4%) 4 (8%) 4 (8%)
Necrosis 3 (6%) 4 (8%) 3 (6%) 3 (6%)
Regeneration 1 (2%) 3 (6%)
Vacuolization Cytoplasmic, Focal 1 (2%)
Bile Duct, Hyperplasia 8 (16%) 8 (16%) 8 (16%) 5 (10%)
Centrilobular, Necrosis 2 (4%) 1 (2%) 1 (2%) 5 (10%)
Kupffer Cell, Pigmentation 15 (30%) 19 (38%) 36 (72%) 47 (94%)
Mesentery (12) (9) (8) (3)
Artery, Inflammation, Chronic Active 1 (13%)
Fat, Necrosis 12 (100%) 9 (100%) 6 (75%) 3 (100%)
Oral Mucosa (1)
Pharyngeal, Hyperplasia, Squamous 1 (100%)
Pancreas (50) (50) (50) (50)
Atrophy 17 (34%) 15 (30%) 13 (26%) 13 (26%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05197-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-BUTOXYETHANOL Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 31.2 PPM 62.5 PPM 125 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Basophilic Focus 2 (4%) 5 (10%) 4 (8%)
Hyperplasia 1 (2%) 1 (2%)
Salivary Glands (50) (50) (50) (49)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Mineralization 1 (2%)
Ulcer 2 (4%) 4 (8%) 7 (14%) 3 (6%)
Epithelium, Hyperplasia 3 (6%) 5 (10%) 6 (12%) 2 (4%)
Stomach, Glandular (50) (50) (49) (50)
Mineralization 3 (6%) 3 (6%) 2 (4%) 8 (16%)
Necrosis 2 (4%) 3 (6%) 4 (8%) 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50)
Cardiomyopathy 34 (68%) 31 (62%) 34 (68%) 30 (60%)
Atrium, Thrombosis 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Atrophy 1 (2%) 1 (2%)
Degeneration, Cystic 1 (2%) 3 (6%)
Hyperplasia 28 (56%) 24 (48%) 19 (38%) 20 (40%)
Hypertrophy 18 (36%) 11 (22%) 9 (18%) 7 (14%)
Necrosis 3 (6%) 4 (8%) 3 (6%)
Vacuolization Cytoplasmic 7 (14%) 9 (18%) 1 (2%) 5 (10%)
Adrenal Medulla (50) (50) (49) (49)
Hyperplasia 11 (22%) 11 (22%) 8 (16%) 17 (35%)
Islets, Pancreatic (50) (50) (49) (50)
Hyperplasia 2 (4%)
Parathyroid Gland (46) (48) (42) (43)
Hyperplasia 1 (2%)
Pituitary Gland (50) (50) (49) (49)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 15 (30%) 14 (28%) 11 (22%) 23 (47%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (50) (48) (49) (50)
C-Cell, Hyperplasia 37 (74%) 41 (85%) 36 (73%) 29 (58%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05197-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-BUTOXYETHANOL Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 31.2 PPM 62.5 PPM 125 PPM
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (46) (45) (44) (48)
Hyperplasia 7 (15%) 4 (9%) 2 (5%) 2 (4%)
Ovary (50) (50) (50) (50)
Cyst 9 (18%) 7 (14%) 3 (6%) 4 (8%)
Hyperplasia 1 (2%)
Inflammation, Granulomatous 1 (2%) 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Uterus (50) (50) (50) (50)
Prolapse 1 (2%)
Endometrium, Hyperplasia, Cystic 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Atrophy 1 (2%)
Hyperplasia 5 (10%) 2 (4%) 2 (4%) 6 (12%)
Hyperplasia, Histiocytic 2 (4%) 1 (2%) 1 (2%)
Lymph Node (5) (3) (6) (2)
Renal, Infiltration Cellular, Plasma Cell 1 (17%)
Spleen (50) (50) (50) (50)
Fibrosis 2 (4%) 6 (12%) 7 (14%) 7 (14%)
Hematopoietic Cell Proliferation 11 (22%) 17 (34%) 6 (12%) 4 (8%)
Hemorrhage 1 (2%) 1 (2%)
Necrosis 1 (2%)
Pigmentation, Hemosiderin 48 (96%) 48 (96%) 48 (96%) 49 (98%)
Thymus (48) (47) (49) (44)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (49)
Galactocele 2 (4%)
Hyperplasia, Atypical 1 (2%)
Skin (49) (50) (50) (50)
Cyst 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05197-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-BUTOXYETHANOL Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 31.2 PPM 62.5 PPM 125 PPM
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 9 (18%) 10 (20%) 8 (16%) 9 (18%)
Inflammation, Chronic 1 (2%)
Skeletal Muscle (1) (2)
Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Hydrocephalus 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Epiglottis, Metaplasia, Squamous 1 (2%) 4 (8%) 2 (4%) 1 (2%)
Lung (50) (50) (50) (49)
Foreign Body 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 1 (2%)
Inflammation, Chronic Active 11 (22%) 11 (22%) 9 (18%) 13 (27%)
Inflammation, Granulomatous 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 17 (34%) 7 (14%) 8 (16%) 5 (10%)
Artery, Infiltration Cellular, Histiocyte 1 (2%)
Nose (50) (48) (50) (49)
Inflammation, Chronic 3 (6%) 1 (2%)
Inflammation, Suppurative 9 (18%) 8 (17%) 5 (10%) 4 (8%)
Thrombosis 2 (4%) 4 (8%) 6 (12%) 5 (10%)
Olfactory Epithelium, Degeneration, Hyaline 13 (26%) 18 (38%) 28 (56%) 40 (82%)
Olfactory Epithelium, Metaplasia 3 (6%) 2 (4%) 3 (6%)
Olfactory Epithelium, Metaplasia, Squamous 1 (2%)
Respiratory Epithelium, Hyperplasia 2 (4%) 2 (4%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%) 3 (6%) 1 (2%)
Trachea (50) (50) (50) (50)
Infiltration Cellular, Polymorphonuclear 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05197-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-BUTOXYETHANOL Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL 31.2 PPM 62.5 PPM 125 PPM
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (7) (3) (1)
Cataract 5 (71%) 2 (67%) 1 (100%)
Degeneration 1 (33%)
Hemorrhage 1 (14%)
Retina, Atrophy 5 (71%) 1 (33%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Infarct 1 (2%) 2 (4%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Nephropathy 47 (94%) 48 (96%) 43 (86%) 46 (92%)
Papilla, Necrosis 1 (2%)
Pelvis, Inflammation, Acute 1 (2%)
Renal Tubule, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Necrosis 2 (4%)
Urinary Bladder (50) (50) (49) (50)
Inflammation, Granulomatous 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05197-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-BUTOXYETHANOL Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 31.2 PPM 62.5 PPM 125 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Natural Death 6 8 5 5
Moribund Sacrifice 25 31 24 21
Survivors
Terminal Sacrifice 19 11 21 24
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (47) (47) (47) (48)
Parasite Metazoan 4 (9%) 4 (9%) 4 (9%) 4 (8%)
Intestine Large, Rectum (46) (47) (48) (47)
Parasite Metazoan 1 (2%) 2 (4%) 6 (13%) 3 (6%)
Perforation 1 (2%)
Intestine Large, Cecum (46) (47) (47) (46)
Necrosis 1 (2%)
Parasite Metazoan 6 (13%) 7 (15%) 4 (9%) 5 (11%)
Intestine Small, Duodenum (46) (47) (49) (49)
Necrosis 1 (2%)
Intestine Small, Ileum (45) (45) (46) (47)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Liver (50) (50) (50) (50)
Angiectasis 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Basophilic Focus 26 (52%) 21 (42%) 25 (50%) 27 (54%)
Clear Cell Focus 10 (20%) 7 (14%) 13 (26%) 9 (18%)
Cyst 1 (2%)
Degeneration, Cystic 7 (14%) 6 (12%) 15 (30%) 6 (12%)
Eosinophilic Focus 6 (12%) 4 (8%) 3 (6%) 4 (8%)
Fatty Change 7 (14%) 10 (20%) 6 (12%) 3 (6%)
Hematopoietic Cell Proliferation 2 (4%) 3 (6%) 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%) 2 (4%) 1 (2%)
Mixed Cell Focus 1 (2%) 1 (2%) 1 (2%)
Necrosis 7 (14%) 9 (18%) 4 (8%) 11 (22%)
Regeneration 1 (2%) 4 (8%)
Thrombosis 1 (2%) 1 (2%) 1 (2%)
Bile Duct, Hyperplasia 28 (56%) 29 (58%) 30 (60%) 36 (72%)
Centrilobular, Necrosis 4 (8%) 9 (18%) 5 (10%) 4 (8%)
Kupffer Cell, Pigmentation 23 (46%) 30 (60%) 34 (68%) 42 (84%)
Mesentery (8) (6) (15) (8)
Fat, Necrosis 8 (100%) 6 (100%) 11 (73%) 8 (100%)
Oral Mucosa (3) (1) (1)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05197-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-BUTOXYETHANOL Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 31.2 PPM 62.5 PPM 125 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pharyngeal, Hyperplasia, Squamous 1 (100%)
Pancreas (50) (50) (50) (50)
Atrophy 25 (50%) 25 (50%) 26 (52%) 22 (44%)
Basophilic Focus 3 (6%) 2 (4%) 5 (10%) 2 (4%)
Hyperplasia 3 (6%) 5 (10%) 2 (4%) 2 (4%)
Salivary Glands (50) (50) (50) (50)
Artery, Mineralization 1 (2%)
Stomach, Forestomach (50) (50) (50) (50)
Mineralization 2 (4%)
Necrosis 1 (2%)
Ulcer 7 (14%) 9 (18%) 3 (6%) 3 (6%)
Epithelium, Hyperplasia 5 (10%) 8 (16%) 4 (8%) 4 (8%)
Stomach, Glandular (49) (49) (50) (50)
Inflammation, Acute 1 (2%)
Mineralization 1 (2%) 3 (6%) 2 (4%) 4 (8%)
Necrosis 4 (8%) 8 (16%) 4 (8%) 10 (20%)
Tooth (3) (1)
Inflammation, Chronic Active 3 (100%) 1 (100%)
Malformation 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (2)
Aorta, Mineralization 2 (100%)
Heart (50) (50) (50) (50)
Cardiomyopathy 42 (84%) 44 (88%) 39 (78%) 41 (82%)
Artery, Mineralization 2 (4%)
Atrium, Thrombosis 1 (2%) 6 (12%) 4 (8%) 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (49) (50)
Atrophy 1 (2%) 3 (6%) 2 (4%)
Hyperplasia 23 (46%) 27 (54%) 25 (51%) 30 (60%)
Hypertrophy 7 (14%) 7 (14%) 8 (16%) 4 (8%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 2 (4%) 2 (4%) 4 (8%) 4 (8%)
Adrenal Medulla (50) (50) (49) (50)
Hyperplasia 24 (48%) 22 (44%) 31 (63%) 27 (54%)
Islets, Pancreatic (50) (50) (50) (50)
Hyperplasia 2 (4%) 4 (8%) 1 (2%)
Parathyroid Gland (47) (46) (47) (44)
Hyperplasia 4 (9%) 7 (15%) 2 (4%) 3 (7%)
Pituitary Gland (49) (49) (48) (47)
Cyst 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05197-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-BUTOXYETHANOL Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 31.2 PPM 62.5 PPM 125 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Mineralization 1 (2%)
Pars Distalis, Hyperplasia 16 (33%) 12 (24%) 16 (33%) 14 (30%)
Pars Intermedia, Hyperplasia 1 (2%) 1 (2%)
Thyroid Gland (50) (46) (48) (48)
C-Cell, Hyperplasia 23 (46%) 31 (67%) 32 (67%) 17 (35%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 (2%) 1 (2%) 1 (2%)
Preputial Gland (46) (47) (50) (43)
Hyperplasia 3 (6%) 4 (9%)
Inflammation, Chronic Active 1 (2%) 5 (11%) 2 (4%) 1 (2%)
Prostate (49) (49) (50) (50)
Hyperplasia 6 (12%) 9 (18%) 4 (8%) 8 (16%)
Inflammation, Chronic Active 4 (8%) 3 (6%) 2 (4%) 1 (2%)
Seminal Vesicle (47) (44) (46) (48)
Hyperplasia 1 (2%)
Mineralization 2 (5%)
Testes (50) (50) (50) (50)
Atrophy 2 (4%) 2 (4%) 1 (2%) 2 (4%)
Artery, Inflammation, Chronic Active 1 (2%)
Interstitial Cell, Hyperplasia 5 (10%) 2 (4%) 5 (10%) 8 (16%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (49)
Hyperplasia 5 (10%) 4 (8%) 4 (8%) 6 (12%)
Necrosis 1 (2%)
Lymph Node, Mandibular (44) (47) (47) (46)
Infiltration Cellular, Plasma Cell 1 (2%)
Lymph Node, Mediastinal (44) (44) (45) (44)
Infiltration Cellular, Plasma Cell 1 (2%)
Spleen (50) (50) (50) (50)
Fibrosis 11 (22%) 14 (28%) 19 (38%) 20 (40%)
Hematopoietic Cell Proliferation 8 (16%) 8 (16%) 6 (12%) 5 (10%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia, Focal, Lymphoid 1 (2%)
Necrosis 2 (4%) 3 (6%) 3 (6%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05197-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-BUTOXYETHANOL Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 31.2 PPM 62.5 PPM 125 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Pigmentation, Hemosiderin 45 (90%) 45 (90%) 40 (80%) 44 (88%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (44) (40) (44) (45)
Galactocele 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (2%) 1 (2%) 3 (6%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 4 (8%)
Subcutaneous Tissue, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Fibrous Osteodystrophy 1 (2%) 3 (6%)
Hyperostosis 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Compression 1 (2%)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%)
Mineralization 1 (2%) 1 (2%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Hemorrhage 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 1 (2%) 2 (4%)
Inflammation, Chronic Active 1 (2%) 3 (6%) 3 (6%)
Inflammation, Suppurative 1 (2%)
Mineralization 2 (4%)
Necrosis 1 (2%)
Thrombosis 1 (2%)
Alveolar Epithelium, Hyperplasia 5 (10%) 13 (26%) 6 (12%) 14 (28%)
Artery, Infiltration Cellular, Histiocyte 2 (4%)
Artery, Mediastinum, Mineralization 2 (4%)
Mediastinum, Inflammation, Chronic 1 (2%)
Nose (48) (49) (49) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05197-11 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC 2-BUTOXYETHANOL Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY Time: 13:13:42
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL 31.2 PPM 62.5 PPM 125 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Suppurative 7 (15%) 7 (14%) 10 (20%) 5 (10%)
Thrombosis 7 (15%) 13 (27%) 11 (22%) 10 (20%)
Olfactory Epithelium, Degeneration, Hyaline 13 (27%) 21 (43%) 23 (47%) 40 (80%)
Olfactory Epithelium, Metaplasia 4 (8%) 5 (10%) 2 (4%) 3 (6%)
Respiratory Epithelium, Hyperplasia 4 (8%) 4 (8%) 6 (12%) 1 (2%)
Respiratory Epithelium, Metaplasia, Squamous 1 (2%)
Trachea (50) (49) (50) (48)
Infiltration Cellular, Polymorphonuclear 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (1)
Cataract 2 (100%) 2 (100%) 1 (100%)
Retina, Atrophy 2 (100%) 2 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Hydronephrosis 1 (2%)
Infarct 1 (2%) 2 (4%) 1 (2%) 6 (12%)
Mineralization 2 (4%)
Nephropathy 48 (96%) 50 (100%) 49 (98%) 50 (100%)
Cortex, Cyst 1 (2%) 1 (2%)
Pelvis, Inflammation, Acute 1 (2%)
Renal Tubule, Hyperplasia 3 (6%) 1 (2%) 1 (2%)
Renal Tubule, Necrosis 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
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