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TDMS Study 05197-11 Pathology Tables

NTP Experiment-Test: 05197-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:42

                                                    2 YEAR CHRONIC  FINAL#1




       Facility:  Battelle Northwest

       Chemical CAS #:  111-76-0002

       Lock Date:  11/08/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05197-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           21           23           26                                     
    Natural Death                                      3            2            4            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           27           23           21                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (50)         (50)         (49)                                   
      Necrosis                                                                                1 (2%)                                
      Parasite Metazoan                                4 (8%)       5 (10%)      2 (4%)       3 (6%)                                
   Intestine Large, Rectum                            (44)         (47)         (48)         (47)                                   
      Parasite Metazoan                                1 (2%)       4 (9%)       3 (6%)       4 (9%)                                
   Intestine Large, Cecum                             (47)         (49)         (48)         (48)                                   
      Inflammation, Chronic                                                                   1 (2%)                                
      Parasite Metazoan                                8 (17%)      6 (12%)      4 (8%)       5 (10%)                               
   Intestine Small, Ileum                             (47)         (50)         (47)         (47)                                   
      Inflammation, Chronic Active                                  1 (2%)                    1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)       2 (4%)                    1 (2%)                                
      Basophilic Focus                                39 (78%)     41 (82%)     41 (82%)     38 (76%)                               
      Clear Cell Focus                                12 (24%)      8 (16%)      5 (10%)      9 (18%)                               
      Degeneration, Cystic                                                                    1 (2%)                                
      Eosinophilic Focus                              13 (26%)     10 (20%)      6 (12%)      5 (10%)                               
      Fatty Change                                    11 (22%)     12 (24%)     12 (24%)      6 (12%)                               
      Hematopoietic Cell Proliferation                 4 (8%)       5 (10%)      1 (2%)                                             
      Hepatodiaphragmatic Nodule                       9 (18%)      6 (12%)      3 (6%)       1 (2%)                                
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Mixed Cell Focus                                 6 (12%)      2 (4%)       4 (8%)       4 (8%)                                
      Necrosis                                         3 (6%)       4 (8%)       3 (6%)       3 (6%)                                
      Regeneration                                     1 (2%)                                 3 (6%)                                
      Vacuolization Cytoplasmic, Focal                 1 (2%)                                                                       
      Bile Duct, Hyperplasia                           8 (16%)      8 (16%)      8 (16%)      5 (10%)                               
      Centrilobular, Necrosis                          2 (4%)       1 (2%)       1 (2%)       5 (10%)                               
      Kupffer Cell, Pigmentation                      15 (30%)     19 (38%)     36 (72%)     47 (94%)                               
   Mesentery                                          (12)         (9)          (8)          (3)                                    
      Artery, Inflammation, Chronic Active                                       1 (13%)                                            
      Fat, Necrosis                                   12 (100%)     9 (100%)     6 (75%)      3 (100%)                              
   Oral Mucosa                                                                               (1)                                    
      Pharyngeal, Hyperplasia, Squamous                                                       1 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Atrophy                                         17 (34%)     15 (30%)     13 (26%)     13 (26%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05197-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Basophilic Focus                                 2 (4%)       5 (10%)      4 (8%)                                             
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (50)         (49)                                   
      Atrophy                                          1 (2%)       1 (2%)                    1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Mineralization                                                                          1 (2%)                                
      Ulcer                                            2 (4%)       4 (8%)       7 (14%)      3 (6%)                                
      Epithelium, Hyperplasia                          3 (6%)       5 (10%)      6 (12%)      2 (4%)                                
   Stomach, Glandular                                 (50)         (50)         (49)         (50)                                   
      Mineralization                                   3 (6%)       3 (6%)       2 (4%)       8 (16%)                               
      Necrosis                                         2 (4%)       3 (6%)       4 (8%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  34 (68%)     31 (62%)     34 (68%)     30 (60%)                               
      Atrium, Thrombosis                               1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                             1 (2%)                                                          
      Atrophy                                                       1 (2%)       1 (2%)                                             
      Degeneration, Cystic                                          1 (2%)                    3 (6%)                                
      Hyperplasia                                     28 (56%)     24 (48%)     19 (38%)     20 (40%)                               
      Hypertrophy                                     18 (36%)     11 (22%)      9 (18%)      7 (14%)                               
      Necrosis                                                      3 (6%)       4 (8%)       3 (6%)                                
      Vacuolization Cytoplasmic                        7 (14%)      9 (18%)      1 (2%)       5 (10%)                               
   Adrenal Medulla                                    (50)         (50)         (49)         (49)                                   
      Hyperplasia                                     11 (22%)     11 (22%)      8 (16%)     17 (35%)                               
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      2 (4%)                                                                       
   Parathyroid Gland                                  (46)         (48)         (42)         (43)                                   
      Hyperplasia                                                                1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (49)         (49)                                   
      Angiectasis                                      1 (2%)       1 (2%)       1 (2%)                                             
      Pars Distalis, Hyperplasia                      15 (30%)     14 (28%)     11 (22%)     23 (47%)                               
      Pars Intermedia, Hyperplasia                                  1 (2%)                                                          
   Thyroid Gland                                      (50)         (48)         (49)         (50)                                   
      C-Cell, Hyperplasia                             37 (74%)     41 (85%)     36 (73%)     29 (58%)                               
      Follicular Cell, Hyperplasia                                  1 (2%)       1 (2%)       2 (4%)                                
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05197-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (45)         (44)         (48)                                   
      Hyperplasia                                      7 (15%)      4 (9%)       2 (5%)       2 (4%)                                
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Cyst                                             9 (18%)      7 (14%)      3 (6%)       4 (8%)                                
      Hyperplasia                                                   1 (2%)                                                          
      Inflammation, Granulomatous                      1 (2%)                    1 (2%)                                             
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Prolapse                                                                   1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                 1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Hyperplasia                                      5 (10%)      2 (4%)       2 (4%)       6 (12%)                               
      Hyperplasia, Histiocytic                                      2 (4%)       1 (2%)       1 (2%)                                
   Lymph Node                                         (5)          (3)          (6)          (2)                                    
      Renal, Infiltration Cellular, Plasma Cell                                  1 (17%)                                            
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                         2 (4%)       6 (12%)      7 (14%)      7 (14%)                               
      Hematopoietic Cell Proliferation                11 (22%)     17 (34%)      6 (12%)      4 (8%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Necrosis                                                      1 (2%)                                                          
      Pigmentation, Hemosiderin                       48 (96%)     48 (96%)     48 (96%)     49 (98%)                               
   Thymus                                             (48)         (47)         (49)         (44)                                   
      Cyst                                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (49)                                   
      Galactocele                                                   2 (4%)                                                          
      Hyperplasia, Atypical                            1 (2%)                                                                       
   Skin                                               (49)         (50)         (50)         (50)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperkeratosis                                   1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05197-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     9 (18%)     10 (20%)      8 (16%)      9 (18%)                               
      Inflammation, Chronic                            1 (2%)                                                                       
   Skeletal Muscle                                                              (1)          (2)                                    
      Hemorrhage                                                                              1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Hydrocephalus                                                 1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Necrosis                                                                                1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Epiglottis, Metaplasia, Squamous                 1 (2%)       4 (8%)       2 (4%)       1 (2%)                                
   Lung                                               (50)         (50)         (50)         (49)                                   
      Foreign Body                                                  1 (2%)                                                          
      Infiltration Cellular, Histiocyte                             2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                    11 (22%)     11 (22%)      9 (18%)     13 (27%)                               
      Inflammation, Granulomatous                                   1 (2%)                                                          
      Thrombosis                                                                              1 (2%)                                
      Alveolar Epithelium, Hyperplasia                17 (34%)      7 (14%)      8 (16%)      5 (10%)                               
      Artery, Infiltration Cellular, Histiocyte                     1 (2%)                                                          
   Nose                                               (50)         (48)         (50)         (49)                                   
      Inflammation, Chronic                            3 (6%)                    1 (2%)                                             
      Inflammation, Suppurative                        9 (18%)      8 (17%)      5 (10%)      4 (8%)                                
      Thrombosis                                       2 (4%)       4 (8%)       6 (12%)      5 (10%)                               
      Olfactory Epithelium, Degeneration, Hyaline     13 (26%)     18 (38%)     28 (56%)     40 (82%)                               
      Olfactory Epithelium, Metaplasia                 3 (6%)       2 (4%)                    3 (6%)                                
      Olfactory Epithelium, Metaplasia, Squamous                                              1 (2%)                                
      Respiratory Epithelium, Hyperplasia              2 (4%)                    2 (4%)       1 (2%)                                
      Respiratory Epithelium, Metaplasia, Squamous     1 (2%)       3 (6%)                    1 (2%)                                
   Trachea                                            (50)         (50)         (50)         (50)                                   
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05197-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (7)          (3)          (1)                                    
      Cataract                                                      5 (71%)      2 (67%)      1 (100%)                              
      Degeneration                                                               1 (33%)                                            
      Hemorrhage                                                    1 (14%)                                                         
      Retina, Atrophy                                               5 (71%)      1 (33%)      1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Infarct                                                       1 (2%)       2 (4%)       3 (6%)                                
      Inflammation, Suppurative                                     1 (2%)                                                          
      Nephropathy                                     47 (94%)     48 (96%)     43 (86%)     46 (92%)                               
      Papilla, Necrosis                                                                       1 (2%)                                
      Pelvis, Inflammation, Acute                      1 (2%)                                                                       
      Renal Tubule, Hyperplasia                        1 (2%)       1 (2%)                                                          
      Renal Tubule, Necrosis                                                                  2 (4%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Inflammation, Granulomatous                      1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05197-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            8            5            5                                     
    Moribund Sacrifice                                25           31           24           21                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           11           21           24                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (47)         (47)         (47)         (48)                                   
      Parasite Metazoan                                4 (9%)       4 (9%)       4 (9%)       4 (8%)                                
   Intestine Large, Rectum                            (46)         (47)         (48)         (47)                                   
      Parasite Metazoan                                1 (2%)       2 (4%)       6 (13%)      3 (6%)                                
      Perforation                                                                1 (2%)                                             
   Intestine Large, Cecum                             (46)         (47)         (47)         (46)                                   
      Necrosis                                                                                1 (2%)                                
      Parasite Metazoan                                6 (13%)      7 (15%)      4 (9%)       5 (11%)                               
   Intestine Small, Duodenum                          (46)         (47)         (49)         (49)                                   
      Necrosis                                                      1 (2%)                                                          
   Intestine Small, Ileum                             (45)         (45)         (46)         (47)                                   
      Inflammation, Acute                                                                     1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)                                
      Parasite Metazoan                                1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Basophilic Focus                                26 (52%)     21 (42%)     25 (50%)     27 (54%)                               
      Clear Cell Focus                                10 (20%)      7 (14%)     13 (26%)      9 (18%)                               
      Cyst                                             1 (2%)                                                                       
      Degeneration, Cystic                             7 (14%)      6 (12%)     15 (30%)      6 (12%)                               
      Eosinophilic Focus                               6 (12%)      4 (8%)       3 (6%)       4 (8%)                                
      Fatty Change                                     7 (14%)     10 (20%)      6 (12%)      3 (6%)                                
      Hematopoietic Cell Proliferation                 2 (4%)       3 (6%)                    1 (2%)                                
      Hepatodiaphragmatic Nodule                       1 (2%)       2 (4%)                    1 (2%)                                
      Mixed Cell Focus                                              1 (2%)       1 (2%)       1 (2%)                                
      Necrosis                                         7 (14%)      9 (18%)      4 (8%)      11 (22%)                               
      Regeneration                                     1 (2%)                    4 (8%)                                             
      Thrombosis                                       1 (2%)                    1 (2%)       1 (2%)                                
      Bile Duct, Hyperplasia                          28 (56%)     29 (58%)     30 (60%)     36 (72%)                               
      Centrilobular, Necrosis                          4 (8%)       9 (18%)      5 (10%)      4 (8%)                                
      Kupffer Cell, Pigmentation                      23 (46%)     30 (60%)     34 (68%)     42 (84%)                               
   Mesentery                                          (8)          (6)          (15)         (8)                                    
      Fat, Necrosis                                    8 (100%)     6 (100%)    11 (73%)      8 (100%)                              
   Oral Mucosa                                        (3)          (1)          (1)                                                 

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05197-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Pharyngeal, Hyperplasia, Squamous                                          1 (100%)                                           
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Atrophy                                         25 (50%)     25 (50%)     26 (52%)     22 (44%)                               
      Basophilic Focus                                 3 (6%)       2 (4%)       5 (10%)      2 (4%)                                
      Hyperplasia                                      3 (6%)       5 (10%)      2 (4%)       2 (4%)                                
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
      Artery, Mineralization                                        1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Mineralization                                                2 (4%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Ulcer                                            7 (14%)      9 (18%)      3 (6%)       3 (6%)                                
      Epithelium, Hyperplasia                          5 (10%)      8 (16%)      4 (8%)       4 (8%)                                
   Stomach, Glandular                                 (49)         (49)         (50)         (50)                                   
      Inflammation, Acute                                           1 (2%)                                                          
      Mineralization                                   1 (2%)       3 (6%)       2 (4%)       4 (8%)                                
      Necrosis                                         4 (8%)       8 (16%)      4 (8%)      10 (20%)                               
   Tooth                                              (3)          (1)                                                              
      Inflammation, Chronic Active                     3 (100%)     1 (100%)                                                        
      Malformation                                     1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (2)                                                              
      Aorta, Mineralization                                         2 (100%)                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  42 (84%)     44 (88%)     39 (78%)     41 (82%)                               
      Artery, Mineralization                                        2 (4%)                                                          
      Atrium, Thrombosis                               1 (2%)       6 (12%)      4 (8%)       3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Atrophy                                          1 (2%)                    3 (6%)       2 (4%)                                
      Hyperplasia                                     23 (46%)     27 (54%)     25 (51%)     30 (60%)                               
      Hypertrophy                                      7 (14%)      7 (14%)      8 (16%)      4 (8%)                                
      Necrosis                                         1 (2%)                    1 (2%)       1 (2%)                                
      Vacuolization Cytoplasmic                        2 (4%)       2 (4%)       4 (8%)       4 (8%)                                
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                     24 (48%)     22 (44%)     31 (63%)     27 (54%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Hyperplasia                                                   2 (4%)       4 (8%)       1 (2%)                                
   Parathyroid Gland                                  (47)         (46)         (47)         (44)                                   
      Hyperplasia                                      4 (9%)       7 (15%)      2 (4%)       3 (7%)                                
   Pituitary Gland                                    (49)         (49)         (48)         (47)                                   
      Cyst                                             1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05197-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Mineralization                                                1 (2%)                                                          
      Pars Distalis, Hyperplasia                      16 (33%)     12 (24%)     16 (33%)     14 (30%)                               
      Pars Intermedia, Hyperplasia                                               1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (46)         (48)         (48)                                   
      C-Cell, Hyperplasia                             23 (46%)     31 (67%)     32 (67%)     17 (35%)                               
      Follicular Cell, Hyperplasia                                               1 (2%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
      Granuloma Sperm                                  1 (2%)       1 (2%)                    1 (2%)                                
   Preputial Gland                                    (46)         (47)         (50)         (43)                                   
      Hyperplasia                                                   3 (6%)                    4 (9%)                                
      Inflammation, Chronic Active                     1 (2%)       5 (11%)      2 (4%)       1 (2%)                                
   Prostate                                           (49)         (49)         (50)         (50)                                   
      Hyperplasia                                      6 (12%)      9 (18%)      4 (8%)       8 (16%)                               
      Inflammation, Chronic Active                     4 (8%)       3 (6%)       2 (4%)       1 (2%)                                
   Seminal Vesicle                                    (47)         (44)         (46)         (48)                                   
      Hyperplasia                                                                             1 (2%)                                
      Mineralization                                                2 (5%)                                                          
   Testes                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                          2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
      Interstitial Cell, Hyperplasia                   5 (10%)      2 (4%)       5 (10%)      8 (16%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
      Hyperplasia                                      5 (10%)      4 (8%)       4 (8%)       6 (12%)                               
      Necrosis                                                                   1 (2%)                                             
   Lymph Node, Mandibular                             (44)         (47)         (47)         (46)                                   
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
   Lymph Node, Mediastinal                            (44)         (44)         (45)         (44)                                   
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibrosis                                        11 (22%)     14 (28%)     19 (38%)     20 (40%)                               
      Hematopoietic Cell Proliferation                 8 (16%)      8 (16%)      6 (12%)      5 (10%)                               
      Hemorrhage                                                                 1 (2%)       1 (2%)                                
      Hyperplasia, Focal, Lymphoid                                  1 (2%)                                                          
      Necrosis                                         2 (4%)       3 (6%)       3 (6%)       3 (6%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05197-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Pigmentation, Hemosiderin                       45 (90%)     45 (90%)     40 (80%)     44 (88%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (40)         (44)         (45)                                   
      Galactocele                                                                1 (2%)       1 (2%)                                
      Hyperplasia                                                                1 (2%)                                             
   Skin                                               (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Hyperkeratosis                                   1 (2%)       1 (2%)       3 (6%)                                             
      Inflammation, Chronic Active                     2 (4%)       1 (2%)       4 (8%)                                             
      Subcutaneous Tissue, Thrombosis                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           1 (2%)       3 (6%)                                                          
      Hyperostosis                                                               2 (4%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Compression                                                                             1 (2%)                                
      Hemorrhage                                                    1 (2%)                                                          
      Hydrocephalus                                                                           1 (2%)                                
      Mineralization                                                1 (2%)                    1 (2%)                                
      Thrombosis                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                       1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                1 (2%)       1 (2%)       2 (4%)                                             
      Inflammation, Chronic Active                                  1 (2%)       3 (6%)       3 (6%)                                
      Inflammation, Suppurative                                                  1 (2%)                                             
      Mineralization                                                2 (4%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Thrombosis                                                    1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia                 5 (10%)     13 (26%)      6 (12%)     14 (28%)                               
      Artery, Infiltration Cellular, Histiocyte        2 (4%)                                                                       
      Artery, Mediastinum, Mineralization                           2 (4%)                                                          
      Mediastinum, Inflammation, Chronic               1 (2%)                                                                       
   Nose                                               (48)         (49)         (49)         (50)                                   

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05197-11         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:42  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Suppurative                        7 (15%)      7 (14%)     10 (20%)      5 (10%)                               
      Thrombosis                                       7 (15%)     13 (27%)     11 (22%)     10 (20%)                               
      Olfactory Epithelium, Degeneration, Hyaline     13 (27%)     21 (43%)     23 (47%)     40 (80%)                               
      Olfactory Epithelium, Metaplasia                 4 (8%)       5 (10%)      2 (4%)       3 (6%)                                
      Respiratory Epithelium, Hyperplasia              4 (8%)       4 (8%)       6 (12%)      1 (2%)                                
      Respiratory Epithelium, Metaplasia, Squamous                               1 (2%)                                             
   Trachea                                            (50)         (49)         (50)         (48)                                   
      Infiltration Cellular, Polymorphonuclear                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                       (2)          (1)                                    
      Cataract                                         2 (100%)                  2 (100%)     1 (100%)                              
      Retina, Atrophy                                  2 (100%)                  2 (100%)     1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Hydronephrosis                                                1 (2%)                                                          
      Infarct                                          1 (2%)       2 (4%)       1 (2%)       6 (12%)                               
      Mineralization                                                2 (4%)                                                          
      Nephropathy                                     48 (96%)     50 (100%)    49 (98%)     50 (100%)                              
      Cortex, Cyst                                                  1 (2%)       1 (2%)                                             
      Pelvis, Inflammation, Acute                      1 (2%)                                                                       
      Renal Tubule, Hyperplasia                        3 (6%)       1 (2%)                    1 (2%)                                
      Renal Tubule, Necrosis                                        2 (4%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
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