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TDMS Study 05197-11 Pathology Tables

NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51

                                                    2 YEAR CHRONIC  FINAL#1




       Facility:  Battelle Northwest

       Chemical CAS #:  111-76-0002

       Lock Date:  11/08/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                18           21           23           26                                     
    Natural Death                                      3            2            4            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           27           23           21                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Intestine Large, Rectum                            (44)         (47)         (48)         (47)                                   
   Intestine Large, Cecum                             (47)         (49)         (48)         (48)                                   
   Intestine Small, Duodenum                          (49)         (49)         (49)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Intestine Small, Jejunum                           (47)         (49)         (47)         (48)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Intestine Small, Ileum                             (47)         (50)         (47)         (47)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Liver                                              (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Mesentery                                          (12)         (9)          (8)          (3)                                    
      Hemangioma                                                                 1 (13%)                                            
      Sex Cord Stromal Tumor, Malignant,                                                                                            
          Metastatic, Ovary                            1 (8%)                                                                       
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                    2 (4%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Bilateral, Carcinoma                                                       1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (49)         (49)                                   
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Pheochromocytoma Malignant                                                              1 (2%)                                
      Pheochromocytoma Benign                          3 (6%)       4 (8%)       1 (2%)       6 (12%)                               
      Bilateral, Pheochromocytoma Benign                                                      1 (2%)                                
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Adenoma                                          1 (2%)                                 1 (2%)                                
      Carcinoma                                                     1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (49)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Pars Distalis, Adenoma                          33 (66%)     32 (64%)     30 (61%)     20 (41%)                               
   Thyroid Gland                                      (50)         (48)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      C-Cell, Adenoma                                  6 (12%)      2 (4%)       5 (10%)      5 (10%)                               
      C-Cell, Carcinoma                                                          2 (4%)       2 (4%)                                
      Follicular Cell, Adenoma                         1 (2%)                                 1 (2%)                                
      Follicular Cell, Carcinoma                       1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                                (1)                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (46)         (45)         (44)         (48)                                   
      Adenoma                                          6 (13%)      3 (7%)       4 (9%)       4 (8%)                                
      Carcinoma                                        3 (7%)       1 (2%)       3 (7%)       2 (4%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Granulosa Cell Tumor Benign                                                1 (2%)                                             
      Granulosa-Theca Tumor Malignant                                                         1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sex Cord Stromal Tumor, Malignant                1 (2%)                                                                       
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Carcinoma                                                                               1 (2%)                                
      Deciduoma Benign                                 1 (2%)                                                                       
      Deciduoma NOS                                    1 (2%)                                                                       
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             

                                                             Page   3                                                               
NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Polyp Stromal                                    6 (12%)      3 (6%)       5 (10%)      2 (4%)                                
      Polyp Stromal, Multiple                                                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
   Lymph Node                                         (5)          (3)          (6)          (2)                                    
      Histiocytic Sarcoma                                                        1 (17%)                                            
      Renal, Histiocytic Sarcoma                                                 1 (17%)                                            
      Renal, Osteosarcoma, Metastatic, Bone            1 (20%)                                                                      
   Lymph Node, Bronchial                              (33)         (36)         (34)         (26)                                   
      Histiocytic Sarcoma                                                        1 (3%)                                             
   Lymph Node, Mandibular                             (49)         (43)         (46)         (46)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mesenteric                             (48)         (50)         (50)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lymph Node, Mediastinal                            (38)         (43)         (39)         (28)                                   
      Histiocytic Sarcoma                                                        1 (3%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (48)         (47)         (49)         (44)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (49)                                   
      Carcinoma                                        3 (6%)       4 (8%)       4 (8%)       3 (6%)                                
      Fibroadenoma                                    19 (38%)     16 (32%)     10 (20%)     12 (24%)                               
      Fibroadenoma, Multiple                           4 (8%)       8 (16%)     10 (20%)      3 (6%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Skin                                               (49)         (50)         (50)         (50)                                   
      Basal Cell Carcinoma                             1 (2%)       1 (2%)                                                          
      Keratoacanthoma                                  2 (4%)                                                                       
      Squamous Cell Papilloma                                                                 2 (4%)                                
      Subcutaneous Tissue, Fibroma                                  1 (2%)                    1 (2%)                                
      Subcutaneous Tissue, Lipoma                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Chordoma                                                                                1 (2%)                                
      Osteosarcoma, Multiple                           1 (2%)                                                                       
   Skeletal Muscle                                                              (1)          (2)                                    
      Hemangioma                                                                 1 (100%)                                           

                                                             Page   4                                                               
NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - cont                                                                                                       
      Sarcoma                                                                                 1 (50%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Malignant                                         1 (2%)                                                          
      Glioma Malignant                                                           1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Lung                                               (50)         (50)         (50)         (49)                                   
      Carcinoma, Metastatic, Mammary Gland                                                    1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)       1 (2%)                                
      Chordoma, Metastatic, Bone                                                              1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Sarcoma, Metastatic, Skeletal Muscle                                                    1 (2%)                                
   Nose                                               (50)         (48)         (50)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                                  (1)                       (1)                                    
      Carcinoma                                                     1 (100%)                  1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Osteosarcoma, Metastatic, Bone                   1 (2%)                                                                       
      Sex Cord Stromal Tumor, Malignant,                                                                                            
          Metastatic, Ovary                            1 (2%)                                                                       
      Renal Tubule, Carcinoma                                                                 1 (2%)                                
   Urinary Bladder                                    (50)         (50)         (49)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             

                                                             Page   5                                                               
NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Leukemia Mononuclear                            18 (36%)     21 (42%)     23 (46%)     24 (48%)                               
      Mesothelioma Malignant                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   6                                                               
NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          48          50          48                                       
     Total Primary Neoplasms                          112          99         108          98                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          43          40          37                                       
     Total Benign Neoplasms                            83          69          72          58                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          26          30          32                                       
     Total Malignant Neoplasms                         28          30          36          40                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                       1           4                                       
     Total Metastatic Neoplasm                          7                       1           4                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            8            5            5                                     
    Moribund Sacrifice                                25           31           24           21                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                19           11           21           24                                     

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)                                   
   Intestine Large, Colon                             (47)         (47)         (47)         (48)                                   
   Intestine Large, Cecum                             (46)         (47)         (47)         (46)                                   
   Intestine Small, Duodenum                          (46)         (47)         (49)         (49)                                   
   Intestine Small, Ileum                             (45)         (45)         (46)         (47)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Islets, Pancreatic        1 (2%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Hepatocellular Carcinoma                                      1 (2%)                    1 (2%)                                
      Hepatocellular Adenoma                           1 (2%)       2 (4%)                    1 (2%)                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
   Mesentery                                          (8)          (6)          (15)         (8)                                    
      Hemangiosarcoma, Metastatic, Spleen                                        1 (7%)                                             
      Sarcoma                                                                    1 (7%)                                             
      Sarcoma, Metastatic, Spleen                                                1 (7%)                                             
   Oral Mucosa                                        (3)          (1)          (1)                                                 
      Gingival, Fibrosarcoma                                        1 (100%)                                                        
      Pharyngeal, Squamous Cell Papilloma              3 (100%)                                                                     
   Pancreas                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)                    3 (6%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
   Stomach, Glandular                                 (49)         (49)         (50)         (50)                                   
   Tongue                                             (1)                       (1)                                                 
      Squamous Cell Papilloma                          1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Adenoma                                          2 (4%)                    1 (2%)                                             
      Carcinoma                                                                  1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Pheochromocytoma Malignant                                    2 (4%)       3 (6%)                                             
      Pheochromocytoma Benign                         12 (24%)     15 (30%)      9 (18%)     12 (24%)                               
      Bilateral, Pheochromocytoma Benign               3 (6%)       5 (10%)      4 (8%)       4 (8%)                                
   Islets, Pancreatic                                 (50)         (50)         (50)         (50)                                   
      Adenoma                                          5 (10%)      2 (4%)       3 (6%)       3 (6%)                                
      Adenoma, Multiple                                                          1 (2%)       1 (2%)                                
      Carcinoma                                        4 (8%)       1 (2%)                    3 (6%)                                
   Pituitary Gland                                    (49)         (49)         (48)         (47)                                   
      Pars Distalis, Adenoma                          24 (49%)     29 (59%)     24 (50%)     25 (53%)                               
   Thyroid Gland                                      (50)         (46)         (48)         (48)                                   
      C-Cell, Adenoma                                  7 (14%)      3 (7%)       7 (15%)     10 (21%)                               
      C-Cell, Carcinoma                                1 (2%)                    3 (6%)       2 (4%)                                
      Follicular Cell, Adenoma                         1 (2%)                                 3 (6%)                                
      Follicular Cell, Carcinoma                       1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                                                   (2)          (1)                                    
   Tissue NOS                                                      (1)                                                              
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (46)         (47)         (50)         (43)                                   
      Adenoma                                          3 (7%)       1 (2%)       5 (10%)      5 (12%)                               
      Carcinoma                                        5 (11%)      1 (2%)       2 (4%)       1 (2%)                                
   Prostate                                           (49)         (49)         (50)         (50)                                   
      Adenoma                                          1 (2%)                    4 (8%)       1 (2%)                                
      Adenoma, Multiple                                                                       1 (2%)                                
   Seminal Vesicle                                    (47)         (44)         (46)         (48)                                   
      Adenoma                                          1 (2%)                                                                       
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           34 (68%)     38 (76%)     36 (72%)     31 (62%)                               
      Interstitial Cell, Adenoma                       7 (14%)      4 (8%)       8 (16%)     10 (20%)                               

                                                             Page   9                                                               
NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
   Lymph Node                                         (10)         (10)         (8)          (10)                                   
      Sarcoma, Metastatic, Skin                                                               1 (10%)                               
   Lymph Node, Bronchial                              (36)         (38)         (41)         (34)                                   
   Lymph Node, Mandibular                             (44)         (47)         (47)         (46)                                   
   Lymph Node, Mesenteric                             (50)         (49)         (50)         (50)                                   
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Sarcoma, Metastatic, Spleen                                                1 (2%)                                             
   Lymph Node, Mediastinal                            (44)         (44)         (45)         (44)                                   
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Fibroma                                                                    1 (2%)       1 (2%)                                
      Hemangiosarcoma                                                            1 (2%)                                             
      Sarcoma                                                                    1 (2%)       1 (2%)                                
   Thymus                                             (45)         (44)         (44)         (39)                                   
      Thymoma Malignant                                                          1 (2%)       1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (44)         (40)         (44)         (45)                                   
      Carcinoma                                                     1 (3%)                                                          
      Fibroadenoma                                     2 (5%)       1 (3%)       3 (7%)       1 (2%)                                
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                               2 (4%)       1 (2%)                                                          
      Basal Cell Carcinoma                             2 (4%)       1 (2%)                                                          
      Keratoacanthoma                                  3 (6%)       3 (6%)       4 (8%)       2 (4%)                                
      Keratoacanthoma, Multiple                                                               1 (2%)                                
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       4 (8%)       1 (2%)                                
      Sebaceous Gland, Adenoma                                                   2 (4%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)       2 (4%)       2 (4%)       3 (6%)                                
      Subcutaneous Tissue, Fibroma, Multiple                                                  1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma, Multiple      1 (2%)                                                                       
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
      Subcutaneous Tissue, Lipoma                      1 (2%)       1 (2%)       2 (4%)                                             
      Subcutaneous Tissue, Sarcoma                                                            2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  10                                                               
NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteosarcoma                                     1 (2%)                                 1 (2%)                                
   Skeletal Muscle                                                 (1)                                                              
      Sarcoma                                                       1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Astrocytoma Benign                                                                      1 (2%)                                
      Astrocytoma Malignant                                         1 (2%)                                                          
      Carcinoma, Metastatic, Zymbal's Gland                         1 (2%)                                                          
      Glioma Malignant                                 2 (4%)                                                                       
      Meningioma Malignant                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)       2 (4%)       4 (8%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (2%)       1 (2%)       1 (2%)                                
      Carcinoma, Metastatic, Islets, Pancreatic        1 (2%)                                                                       
      Carcinoma, Metastatic, Preputial Gland                                                  1 (2%)                                
      Hemangiosarcoma, Metastatic, Spleen                                        1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)       1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                           1 (2%)       1 (2%)                                             
      Sarcoma, Metastatic, Skin                                                               1 (2%)                                
   Nose                                               (48)         (49)         (49)         (50)                                   
      Lateral Wall, Adenoma                                                      1 (2%)                                             
      Turbinate, Chondroma                                          1 (2%)                                                          
   Pleura                                                                       (1)                                                 
   Trachea                                            (50)         (49)         (50)         (48)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (1)          (2)                                                 
      Carcinoma                                        1 (100%)     1 (100%)     2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  11                                                               
NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Mesenchymal Tumor Malignant                                                1 (2%)                                             
      Sarcoma                                                       1 (2%)                                                          
      Renal Tubule, Adenoma                            1 (2%)       2 (4%)                                                          
      Renal Tubule, Oncocytoma Benign                                            1 (2%)                                             
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
   Urinary Bladder                                    (49)         (50)         (50)         (50)                                   
      Transitional Epithelium, Papilloma               2 (4%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Leukemia Mononuclear                            29 (58%)     31 (62%)     33 (66%)     30 (60%)                               
      Lymphoma Malignant                               1 (2%)                                                                       
      Mesothelioma Benign                              1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Mesothelioma Malignant                                                     3 (6%)       1 (2%)                                
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  12                                                               
NTP Experiment-Test: 05197-11  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 02/16/98  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 13:13:51  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      31.2 PPM     62.5 PPM     125 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50          50                                       
     Total Primary Neoplasms                          173         161         187         163                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 49          49          49          49                                       
     Total Benign Neoplasms                           123         114         131         119                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              40          40          41          38                                       
     Total Malignant Neoplasms                         50          47          56          44                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3           3           2                                       
     Total Metastatic Neoplasm                          4           3           8           3                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms               2           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  13                                                               
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