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TDMS Study 05197-11 Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08
LAB: Battelle Northwest                                     2-BUTOXYETHANOL                                    DATE: 02/23/98

EXPERIMENT: 05197 TEST: 11                                                                                     TIME: 08:59:35
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15318                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 62077D
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 111-76-0002
                 

Rats(FISCHER 344)
-----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.

                                                 ----------------
                                                 Adrenal Gland
                                                 Adrenal Medulla
                                                 Bone Marrow
                                                 Brain
                                                 Clitoral Gland
                                                 Clitoral/Preputial Gland
                                                 Epididymis
                                                 Heart
                                                 Islets, Pancreatic
                                                 Kidney
                                                 Liver
                                                 Lung
                                                 Nose
                                                 Ovary
                                                 Pancreas
                                                 Parathyroid Gland
                                                 Pituitary Gland
                                                 Preputial Gland
                                                 Prostate
                                                 Salivary Glands
                                                 Spleen
                                                 Testes
                                                 Thymus
                                                 Thyroid Gland
                                                 Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08   
LAB: Battelle Northwest                                     2-BUTOXYETHANOL                                    DATE: 02/23/98     
EXPERIMENT: 05197 TEST: 11                                                                                     TIME: 08:59:35     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15318                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 62077D     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 111-76-0002   



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                 2-BUTOXYETHANOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Medulla                        Pheochromocytoma Benign
                                       Pheochromocytoma: Benign, Complex, Malignant, NOS
Clitoral/Preputial Gland               Carcinoma or Adenoma
Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)
                                       Papilloma Squamous or Papilloma
                                       Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma
Oral Mucosa                            Squamous Cell Papilloma
Skin
Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, malignant or NOS), or Trichoepithelioma
                                       Sarcoma
Testes                                 Adenoma
All Organs                             Malignant Tumors
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Medulla                        Pheochromocytoma: Benign, Complex, Malignant, NOS
Mammary Gland                          Fibroadenoma
Pituitary Gland: Pars Distalis or Unspecified Site
                                       Adenoma
Skin                                   Squamous Cell Papilloma
All Organs                             Malignant Tumors
                                       Malignant and Benign Tumors
===============================================================
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 1
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)        -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    1/49 (2%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    2/50 (4%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         0.0%         2.6%         0.0%        |2.3%         0.0%         5.1%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |1/29 (3%)    0/27 (0%)    2/23 (9%)    0/21 (0%)    |
|FIRST INCIDENCE    |     597          ---          542          ---         |730 (T)      ---          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.173N     P=0.305N     P=0.497N     P=0.214N    |P=0.547N     P=0.514N     P=0.419      P=0.564N     |
|POLY 3             |     P=0.177N     P=0.251N     P=0.501N     P=0.230N    |P=0.475N     P=0.501N     P=0.469      P=0.509N     |
|POLY 1.5           |     P=0.183N     P=0.244N     P=0.506N     P=0.234N    |P=0.468N     P=0.500N     P=0.480      P=0.504N     |
|POLY 6             |     P=0.165N     P=0.265N     P=0.488N     P=0.223N    |P=0.488N     P=0.503N     P=0.455      P=0.518N     |
|LOGISTIC REGRESSION|     P=0.193N     P=0.240N     P=0.496N     P=0.238N    |P=0.547N     (e)          P=0.419      (e)          |
|COCH-ARM / FISHERS |     P=0.189N     P=0.247N     P=0.508N     P=0.247N    |P=0.461N     P=0.500N     P=0.500      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/50 (30%)  20/50 (40%)  13/49 (27%)  16/50 (32%) |3/50 (6%)    4/50 (8%)    1/49 (2%)    7/49 (14%)   |
|POLY-3 ADJUSTED (b)|     36.5%        50.3%        32.8%        38.3%       |6.9%         9.2%         2.6%         16.7%        |
|TERMINAL (d)       |     7/19 (37%)   6/11 (55%)   6/21 (29%)   9/24 (38%)  |1/29 (3%)    1/27 (4%)    1/22 (5%)    1/21 (5%)    |
|FIRST INCIDENCE    |     558          533          658          611         |554          584          730 (T)      638          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.136N     P=0.040 *    P=0.315N     P=0.431N    |P=0.068      P=0.484      P=0.385N     P=0.119      |
|POLY 3             |     P=0.424N     P=0.140      P=0.452N     P=0.522     |P=0.090      P=0.499      P=0.353N     P=0.138      |
|POLY 1.5           |     P=0.447N     P=0.170      P=0.455N     P=0.509     |P=0.096      P=0.501      P=0.337N     P=0.144      |
|POLY 6             |     P=0.370N     P=0.097      P=0.427N     P=0.556     |P=0.084      P=0.493      P=0.372N     P=0.129      |
|LOGISTIC REGRESSION|     P=0.334N     P=0.127      P=0.403N     P=0.570     |P=0.103      P=0.497      P=0.324N     P=0.158      |
|COCH-ARM / FISHERS |     P=0.462N     P=0.201      P=0.437N     P=0.500     |P=0.104      P=0.500      P=0.316N     P=0.151      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 2
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    3/49 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.4%         7.7%         0.0%        |0.0%         0.0%         0.0%         2.5%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    1/21 (5%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/22 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          630          622          ---         |---          ---          ---          612          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.451N     P=0.190      P=0.142      (e)         |P=0.202      (e)          (e)          P=0.500      |
|POLY 3             |     P=0.506N     P=0.227      P=0.119      (e)         |P=0.191      (e)          (e)          P=0.489      |
|POLY 1.5           |     P=0.519N     P=0.232      P=0.116      (e)         |P=0.194      (e)          (e)          P=0.493      |
|POLY 6             |     P=0.481N     P=0.217      P=0.128      (e)         |P=0.187      (e)          (e)          P=0.481      |
|LOGISTIC REGRESSION|     P=0.520N     P=0.225      P=0.117      (e)         |P=0.196      (e)          (e)          P=0.499      |
|COCH-ARM / FISHERS |     P=0.531N     P=0.247      P=0.117      (e)         |P=0.196      (e)          (e)          P=0.495      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     15/50 (30%)  21/50 (42%)  15/49 (31%)  16/50 (32%) |3/50 (6%)    4/50 (8%)    1/49 (2%)    8/49 (16%)   |
|POLY-3 ADJUSTED (b)|     36.5%        52.4%        37.5%        38.3%       |6.9%         9.2%         2.6%         18.9%        |
|TERMINAL (d)       |     7/19 (37%)   6/11 (55%)   7/21 (33%)   9/24 (38%)  |1/29 (3%)    1/27 (4%)    1/22 (5%)    1/21 (5%)    |
|FIRST INCIDENCE    |     558          533          622          611         |554          584          730 (T)      612          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.130N     P=0.028 *    P=0.467N     P=0.431N    |P=0.034 *    P=0.484      P=0.385N     P=0.076      |
|POLY 3             |     P=0.413N     P=0.100      P=0.557      P=0.522     |P=0.044 *    P=0.499      P=0.353N     P=0.086      |
|POLY 1.5           |     P=0.437N     P=0.123      P=0.548      P=0.509     |P=0.047 *    P=0.501      P=0.337N     P=0.090      |
|POLY 6             |     P=0.358N     P=0.069      P=0.595      P=0.556     |P=0.041 *    P=0.493      P=0.372N     P=0.081      |
|LOGISTIC REGRESSION|     P=0.330N     P=0.091      P=0.587N     P=0.570     |P=0.053      P=0.497      P=0.324N     P=0.101      |
|COCH-ARM / FISHERS |     P=0.453N     P=0.149      P=0.560      P=0.500     |P=0.052      P=0.500      P=0.316N     P=0.094      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 3
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Glioma Malignant                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         0.0%         0.0%         0.0%        |0.0%         0.0%         2.5%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     646          ---          ---          ---         |---          ---          247          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.097N     P=0.307N     P=0.222N     P=0.202N    |P=0.694      (e)          P=0.500      (e)          |
|POLY 3             |     P=0.109N     P=0.250N     P=0.238N     P=0.229N    |P=0.679      (e)          P=0.487      (e)          |
|POLY 1.5           |     P=0.112N     P=0.243N     P=0.240N     P=0.233N    |P=0.687      (e)          P=0.492      (e)          |
|POLY 6             |     P=0.104N     P=0.264N     P=0.232N     P=0.221N    |P=0.663      (e)          P=0.480      (e)          |
|LOGISTIC REGRESSION|     P=0.109N     P=0.255N     P=0.235N     P=0.228N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.694      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Brain                                                                                                                            |
|     Oligodendroglioma, Glioma, or Astrocytoma                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         2.7%         0.0%         2.5%        |0.0%         2.3%         2.5%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    1/11 (9%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     646          729 (T)      ---          647         |---          652          247          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.293N     P=0.632N     P=0.222N     P=0.442N    |P=0.599N     P=0.505      P=0.500      (e)          |
|POLY 3             |     P=0.357N     P=0.521N     P=0.238N     P=0.486N    |P=0.608N     P=0.501      P=0.487      (e)          |
|POLY 1.5           |     P=0.363N     P=0.510N     P=0.240N     P=0.493N    |P=0.601N     P=0.501      P=0.492      (e)          |
|POLY 6             |     P=0.346N     P=0.542N     P=0.232N     P=0.472N    |P=0.621N     P=0.499      P=0.480      (e)          |
|LOGISTIC REGRESSION|     P=0.346N     P=0.552N     P=0.235N     P=0.495N    |P=0.576N     P=0.491      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.366N     P=0.500N     P=0.247N     P=0.500N    |P=0.595N     P=0.500      P=0.500      (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 4
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/46 (7%)    1/47 (2%)    5/50 (10%)   5/43 (12%)  |6/46 (13%)   3/45 (7%)    4/44 (9%)    4/48 (8%)    |
|POLY-3 ADJUSTED (b)|     8.4%         2.9%         12.5%        14.4%       |14.9%        7.8%         11.8%        10.1%        |
|TERMINAL (d)       |     1/16 (6%)    1/11 (9%)    2/21 (10%)   2/19 (11%)  |5/27 (19%)   1/23 (4%)    3/20 (15%)   3/20 (15%)   |
|FIRST INCIDENCE    |     610          729 (T)      370          519         |688          722          722          646          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.249      P=0.386N     P=0.439      P=0.427     |P=0.558N     P=0.303N     P=0.549N     P=0.538N     |
|POLY 3             |     P=0.141      P=0.314N     P=0.417      P=0.336     |P=0.385N     P=0.262N     P=0.479N     P=0.374N     |
|POLY 1.5           |     P=0.132      P=0.305N     P=0.408      P=0.328     |P=0.371N     P=0.257N     P=0.448N     P=0.358N     |
|POLY 6             |     P=0.164      P=0.333N     P=0.440      P=0.355     |P=0.411N     P=0.275N     P=0.519N     P=0.405N     |
|LOGISTIC REGRESSION|     P=0.126      P=0.306N     P=0.404      P=0.322     |P=0.491N     P=0.293N     P=0.567N     P=0.449N     |
|COCH-ARM / FISHERS |     P=0.124      P=0.300N     P=0.405      P=0.319     |P=0.355N     P=0.254N     P=0.399N     P=0.343N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/46 (11%)   1/47 (2%)    2/50 (4%)    1/43 (2%)   |3/46 (7%)    1/45 (2%)    3/44 (7%)    2/48 (4%)    |
|POLY-3 ADJUSTED (b)|     14.0%        2.9%         5.2%         3.0%        |7.5%         2.6%         8.7%         5.0%         |
|TERMINAL (d)       |     1/16 (6%)    1/11 (9%)    1/21 (5%)    1/19 (5%)   |2/27 (7%)    1/23 (4%)    1/20 (5%)    1/20 (5%)    |
|FIRST INCIDENCE    |     564          729 (T)      701          729 (T)     |722          730 (T)      583          663          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.055N     P=0.190N     P=0.171N     P=0.076N    |P=0.567      P=0.349N     P=0.560      P=0.611N     |
|POLY 3             |     P=0.089N     P=0.104N     P=0.180N     P=0.112N    |P=0.523N     P=0.320N     P=0.594      P=0.503N     |
|POLY 1.5           |     P=0.094N     P=0.099N     P=0.185N     P=0.115N    |P=0.513N     P=0.316N     P=0.611      P=0.492N     |
|POLY 6             |     P=0.079N     P=0.115N     P=0.168N     P=0.105N    |P=0.541N     P=0.329N     P=0.576      P=0.525N     |
|LOGISTIC REGRESSION|     P=0.078N     P=0.110N     P=0.168N     P=0.105N    |P=0.529N     P=0.351N     P=0.603      P=0.549N     |
|COCH-ARM / FISHERS |     P=0.099N     P=0.097N     P=0.185N     P=0.118N    |P=0.502N     P=0.317N     P=0.640      P=0.480N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 5
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/46 (17%)   2/47 (4%)    7/50 (14%)   6/43 (14%)  |9/46 (20%)   3/45 (7%)    7/44 (16%)   6/48 (13%)   |
|POLY-3 ADJUSTED (b)|     21.9%        5.8%         17.5%        17.3%       |22.4%        7.8%         20.2%        15.0%        |
|TERMINAL (d)       |     2/16 (13%)   2/11 (18%)   3/21 (14%)   3/19 (16%)  |7/27 (26%)   1/23 (4%)    4/20 (20%)   4/20 (20%)   |
|FIRST INCIDENCE    |     564          729 (T)      370          519         |688          722          583          646          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.364N     P=0.114N     P=0.389N     P=0.295N    |P=0.518      P=0.093N     P=0.608N     P=0.488N     |
|POLY 3             |     P=0.559N     P=0.049N*    P=0.421N     P=0.425N    |P=0.395N     P=0.066N     P=0.521N     P=0.285N     |
|POLY 1.5           |     P=0.546      P=0.044N*    P=0.430N     P=0.433N    |P=0.381N     P=0.064N     P=0.487N     P=0.270N     |
|POLY 6             |     P=0.516N     P=0.060N     P=0.399N     P=0.409N    |P=0.421N     P=0.072N     P=0.559N     P=0.316N     |
|LOGISTIC REGRESSION|     P=0.549      P=0.049N*    P=0.429N     P=0.424N    |P=0.468N     P=0.083N     P=0.589N     P=0.370N     |
|COCH-ARM / FISHERS |     P=0.527      P=0.042N*    P=0.429N     P=0.440N    |P=0.366N     P=0.064N     P=0.430N     P=0.257N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    4/50 (8%)    4/50 (8%)   |1/50 (2%)    0/50 (0%)    0/49 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     12.7%        5.4%         10.3%        9.9%        |2.3%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     2/19 (11%)   0/11 (0%)    2/21 (10%)   3/24 (13%)  |0/29 (0%)    0/27 (0%)    0/23 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     610          561          694          654         |718          ---          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.366N     P=0.349N     P=0.438N     P=0.379N    |P=0.519      P=0.519N     P=0.555N     P=0.677      |
|POLY 3             |     P=0.524N     P=0.234N     P=0.507N     P=0.480N    |P=0.585      P=0.501N     P=0.522N     P=0.751      |
|POLY 1.5           |     P=0.540N     P=0.225N     P=0.509N     P=0.490N    |P=0.589      P=0.500N     P=0.515N     P=0.756      |
|POLY 6             |     P=0.490N     P=0.256N     P=0.493N     P=0.460N    |P=0.579      P=0.504N     P=0.529N     P=0.740      |
|LOGISTIC REGRESSION|     P=0.489N     P=0.234N     P=0.473N     P=0.451N    |P=0.546      P=0.505N     P=0.533N     P=0.712      |
|COCH-ARM / FISHERS |     P=0.554N     P=0.218N     P=0.500N     P=0.500N    |P=0.594      P=0.500N     P=0.505N     P=0.753N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 6
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    1/50 (2%)    0/50 (0%)    3/50 (6%)   |0/50 (0%)    1/50 (2%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     10.3%        2.7%         0.0%         7.5%        |0.0%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     2/19 (11%)   1/11 (9%)    0/21 (0%)    3/24 (13%)  |0/29 (0%)    1/27 (4%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     673          729 (T)      ---          729 (T)     |---          730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.347N     P=0.328N     P=0.053N     P=0.388N    |P=0.617N     P=0.486      (e)          (e)          |
|POLY 3             |     P=0.483N     P=0.195N     P=0.060N     P=0.483N    |P=0.576N     P=0.499      (e)          (e)          |
|POLY 1.5           |     P=0.493N     P=0.187N     P=0.061N     P=0.491N    |P=0.572N     P=0.500      (e)          (e)          |
|POLY 6             |     P=0.464N     P=0.215N     P=0.056N     P=0.466N    |P=0.582N     P=0.497      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.395N     P=0.235N     P=0.056N     P=0.422N    |(e)          P=0.486      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.500N     P=0.181N     P=0.059N     P=0.500N    |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     9/50 (18%)   3/50 (6%)    4/50 (8%)    7/50 (14%)  |1/50 (2%)    1/50 (2%)    0/49 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     22.7%        8.0%         10.3%        17.3%       |2.3%         2.3%         0.0%         2.4%         |
|TERMINAL (d)       |     4/19 (21%)   1/11 (9%)    2/21 (10%)   6/24 (25%)  |0/29 (0%)    1/27 (4%)    0/23 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     610          561          694          654         |718          730 (T)      ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.253N     P=0.185N     P=0.091N     P=0.240N    |P=0.606      P=0.742      P=0.555N     P=0.677      |
|POLY 3             |     P=0.452N     P=0.069N     P=0.117N     P=0.371N    |P=0.626N     P=0.760      P=0.522N     P=0.751      |
|POLY 1.5           |     P=0.470N     P=0.063N     P=0.120N     P=0.382N    |P=0.622N     P=0.760N     P=0.515N     P=0.756      |
|POLY 6             |     P=0.414N     P=0.082N     P=0.108N     P=0.350N    |P=0.632N     P=0.757      P=0.529N     P=0.740      |
|LOGISTIC REGRESSION|     P=0.376N     P=0.081N     P=0.096N     P=0.306N    |P=0.627      P=0.754      P=0.533N     P=0.712      |
|COCH-ARM / FISHERS |     P=0.485N     P=0.061N     P=0.117N     P=0.393N    |P=0.616N     P=0.753N     P=0.505N     P=0.753N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 7
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         5.3%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     702          536          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.164N     P=0.441      P=0.476N     P=0.461N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.184N     P=0.488      P=0.500N     P=0.492N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.186N     P=0.495      P=0.502N     P=0.496N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.180N     P=0.473      P=0.494N     P=0.485N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.189N     P=0.504      P=0.492N     P=0.483N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.6%         5.3%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     702          536          ---          ---         |---          ---          ---          617          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.164N     P=0.441      P=0.476N     P=0.461N    |P=0.199      (e)          (e)          P=0.495      |
|POLY 3             |     P=0.184N     P=0.488      P=0.500N     P=0.492N    |P=0.194      (e)          (e)          P=0.493      |
|POLY 1.5           |     P=0.186N     P=0.495      P=0.502N     P=0.496N    |P=0.197      (e)          (e)          P=0.497      |
|POLY 6             |     P=0.180N     P=0.473      P=0.494N     P=0.485N    |P=0.190      (e)          (e)          P=0.485      |
|LOGISTIC REGRESSION|     P=0.189N     P=0.504      P=0.492N     P=0.483N    |P=0.199      (e)          (e)          P=0.503      |
|COCH-ARM / FISHERS |     P=0.188N     P=0.500      P=0.500N     P=0.500N    |P=0.198      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 8
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         5.4%         0.0%         2.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    1/11 (9%)    0/21 (0%)    1/24 (4%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     708          617          ---          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.410N     P=0.394      P=0.475N     P=0.711N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.494N     P=0.485      P=0.500N     P=0.753N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.497N     P=0.493      P=0.502N     P=0.757N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.486N     P=0.469      P=0.494N     P=0.744N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.467N     P=0.473      P=0.489N     P=0.728N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      P=0.500N     P=0.753N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         8.1%         0.0%         4.9%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    1/11 (9%)    0/21 (0%)    1/24 (4%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     708          617          ---          666         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.553N     P=0.212      P=0.475N     P=0.566     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.572      P=0.290      P=0.500N     P=0.516     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.563      P=0.298      P=0.502N     P=0.508     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.588      P=0.274      P=0.494N     P=0.531     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.586      P=0.273      P=0.489N     P=0.528     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.556      P=0.309      P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 9
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma,                                                                           |
|     or Hepatoblastoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         8.1%         0.0%         4.9%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    1/11 (9%)    0/21 (0%)    1/24 (4%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     708          617          ---          666         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.553N     P=0.212      P=0.475N     P=0.566     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.572      P=0.290      P=0.500N     P=0.516     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.563      P=0.298      P=0.502N     P=0.508     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.588      P=0.274      P=0.494N     P=0.531     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.586      P=0.273      P=0.489N     P=0.528     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.556      P=0.309      P=0.500N     P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    4/50 (8%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         5.5%         10.1%        0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    2/11 (18%)   3/21 (14%)   0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/20 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      472          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.252N     P=0.310      P=0.199      P=0.453N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.341N     P=0.482      P=0.183      P=0.492N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.357N     P=0.491      P=0.179      P=0.496N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.311N     P=0.463      P=0.194      P=0.484N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.339N     P=0.310      P=0.179      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.373N     P=0.500      P=0.181      P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 10
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar                                                                      |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    5/50 (10%)   1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         8.2%         12.7%        2.5%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    2/11 (18%)   4/21 (19%)   1/24 (4%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/20 (0%)    |
|FIRST INCIDENCE    |     729 (T)      723          472          729 (T)     |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.365N     P=0.146      P=0.117      P=0.710N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.508N     P=0.285      P=0.104      P=0.752N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.526N     P=0.296      P=0.101      P=0.756N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.472N     P=0.266      P=0.112      P=0.743N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.474N     P=0.169      P=0.104      P=0.710N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.544N     P=0.309      P=0.102      P=0.753N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |3/50 (6%)    4/50 (8%)    4/50 (8%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.7%         0.0%         0.0%        |6.9%         9.1%         9.8%         7.2%         |
|TERMINAL (d)       |     0/19 (0%)    1/11 (9%)    0/21 (0%)    0/24 (0%)   |2/29 (7%)    0/27 (0%)    1/23 (4%)    1/21 (5%)    |
|FIRST INCIDENCE    |     ---          729 (T)      ---          ---         |638          606          462          663          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.503N     P=0.391      (e)          (e)         |P=0.499      P=0.484      P=0.405      P=0.551      |
|POLY 3             |     P=0.571N     P=0.490      (e)          (e)         |P=0.571N     P=0.507      P=0.464      P=0.642      |
|POLY 1.5           |     P=0.569N     P=0.495      (e)          (e)         |P=0.554N     P=0.505      P=0.477      P=0.653      |
|POLY 6             |     P=0.574N     P=0.479      (e)          (e)         |P=0.544      P=0.508      P=0.450      P=0.622      |
|LOGISTIC REGRESSION|     (e)          P=0.391      (e)          (e)         |P=0.524N     P=0.496      P=0.535      P=0.644      |
|COCH-ARM / FISHERS |     P=0.567N     P=0.500      (e)          (e)         |P=0.537N     P=0.500      P=0.500      P=0.661N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 11
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    3/50 (6%)    1/50 (2%)   |23/50 (46%)  24/50 (48%)  20/50 (40%)  15/50 (30%)  |
|POLY-3 ADJUSTED (b)|     7.7%         2.7%         7.6%         2.5%        |49.9%        53.5%        48.2%        33.9%        |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    1/21 (5%)    1/24 (4%)   |14/29 (48%)  15/27 (56%)  12/23 (52%)  5/21 (24%)   |
|FIRST INCIDENCE    |     641          677          565          729 (T)     |508          584          462          462          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.225N     P=0.417N     P=0.622N     P=0.248N    |P=0.259N     P=0.411      P=0.482      P=0.296N     |
|POLY 3             |     P=0.289N     P=0.325N     P=0.661N     P=0.294N    |P=0.043N*    P=0.445      P=0.522N     P=0.088N     |
|POLY 1.5           |     P=0.302N     P=0.315N     P=0.660      P=0.300N    |P=0.038N*    P=0.473      P=0.451N     P=0.079N     |
|POLY 6             |     P=0.266N     P=0.347N     P=0.647N     P=0.283N    |P=0.057N     P=0.401      P=0.570      P=0.110N     |
|LOGISTIC REGRESSION|     P=0.293N     P=0.330N     P=0.662      P=0.281N    |P=0.048N*    P=0.501      P=0.455N     P=0.074N     |
|COCH-ARM / FISHERS |     P=0.313N     P=0.309N     P=0.661N     P=0.309N    |P=0.036N*    P=0.500      P=0.343N     P=0.074N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    3/50 (6%)    1/50 (2%)   |25/50 (50%)  27/50 (54%)  23/50 (46%)  18/50 (36%)  |
|POLY-3 ADJUSTED (b)|     7.7%         5.4%         7.6%         2.5%        |53.8%        58.9%        54.3%        40.4%        |
|TERMINAL (d)       |     1/19 (5%)    1/11 (9%)    1/21 (5%)    1/24 (4%)   |15/29 (52%)  15/27 (56%)  13/23 (57%)  6/21 (29%)   |
|FIRST INCIDENCE    |     641          677          565          729 (T)     |508          584          462          462          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.176N     P=0.652N     P=0.622N     P=0.248N    |P=0.355N     P=0.352      P=0.383      P=0.403N     |
|POLY 3             |     P=0.242N     P=0.527N     P=0.661N     P=0.294N    |P=0.070N     P=0.386      P=0.568      P=0.137N     |
|POLY 1.5           |     P=0.254N     P=0.513N     P=0.660      P=0.300N    |P=0.060N     P=0.404      P=0.532N     P=0.122N     |
|POLY 6             |     P=0.222N     P=0.555N     P=0.647N     P=0.283N    |P=0.095N     P=0.360      P=0.481      P=0.169N     |
|LOGISTIC REGRESSION|     P=0.237N     P=0.549N     P=0.662      P=0.281N    |P=0.068N     P=0.423      P=0.524N     P=0.114N     |
|COCH-ARM / FISHERS |     P=0.263N     P=0.500N     P=0.661N     P=0.309N    |P=0.054N     P=0.421      P=0.421N     P=0.113N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 12
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Papilloma Squamous or Papilloma                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     10.1%        0.0%         2.6%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    1/21 (5%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     609          ---          729 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.030N*    P=0.088N     P=0.166N     P=0.054N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.032N*    P=0.070N     P=0.185N     P=0.058N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.035N*    P=0.065N     P=0.185N     P=0.059N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.028N*    P=0.081N     P=0.181N     P=0.055N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.038N*    P=0.061N     P=0.180N     P=0.065N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.039N*    P=0.059N     P=0.181N     P=0.059N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva)                                                                       |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    0/50 (0%)    1/50 (2%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     10.1%        0.0%         2.6%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    1/21 (5%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     609          ---          729 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.030N*    P=0.088N     P=0.166N     P=0.054N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.032N*    P=0.070N     P=0.185N     P=0.058N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.035N*    P=0.065N     P=0.185N     P=0.059N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.028N*    P=0.081N     P=0.181N     P=0.055N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.038N*    P=0.061N     P=0.180N     P=0.065N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.039N*    P=0.059N     P=0.181N     P=0.059N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 13
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Oral Mucosa                                                                                                                      |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.5%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     609          ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.045N*    P=0.130N     P=0.117N     P=0.113N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.041N*    P=0.133N     P=0.123N     P=0.115N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.043N*    P=0.125N     P=0.122N     P=0.117N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.037N*    P=0.148N     P=0.120N     P=0.112N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.047N*    P=0.115N     P=0.111N     P=0.127N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.047N*    P=0.121N     P=0.121N     P=0.121N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/50 (6%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         0.0%         7.8%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    3/21 (14%)   0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.379N     P=0.609N     P=0.338      P=0.453N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.470N     P=0.510N     P=0.304      P=0.492N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.486N     P=0.505N     P=0.302      P=0.496N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.440N     P=0.521N     P=0.315      P=0.484N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.379N     (e)          P=0.338      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.309      P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 14
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     24/49 (49%)  29/49 (59%)  24/48 (50%)  25/47 (53%) |33/50 (66%)  32/50 (64%)  30/49 (61%)  20/49 (41%)  |
|POLY-3 ADJUSTED (b)|     55.2%        65.0%        55.8%        59.0%       |72.8%        69.1%        69.5%        45.6%        |
|TERMINAL (d)       |     6/18 (33%)   7/11 (64%)   10/20 (50%)  14/23 (61%) |22/29 (76%)  19/27 (70%)  16/23 (70%)  9/21 (43%)   |
|FIRST INCIDENCE    |     520          479          340          495         |575          584          496          462          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.164N     P=0.090      P=0.466N     P=0.405N    |P=0.160N     P=0.517      P=0.340      P=0.181N     |
|POLY 3             |     P=0.522      P=0.223      P=0.562      P=0.442     |P=0.002N**   P=0.430N     P=0.452N     P=0.005N**   |
|POLY 1.5           |     P=0.510      P=0.222      P=0.550      P=0.432     |P=0.003N**   P=0.457N     P=0.426N     P=0.006N**   |
|POLY 6             |     P=0.545      P=0.211      P=0.580      P=0.457     |P=0.003N**   P=0.404N     P=0.480N     P=0.005N**   |
|LOGISTIC REGRESSION|     P=0.488      P=0.224      P=0.542      P=0.419     |P=0.006N**   P=0.502N     P=0.586N     P=0.012N*    |
|COCH-ARM / FISHERS |     P=0.500      P=0.209      P=0.541      P=0.418     |P=0.004N**   P=0.500N     P=0.388N     P=0.010N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    0/49 (0%)    4/50 (8%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     2.7%         0.0%         10.3%        5.0%        |                                                    |
|TERMINAL (d)       |     1/18 (6%)    0/11 (0%)    3/21 (14%)   2/24 (8%)   |                                                    |
|FIRST INCIDENCE    |     729 (T)      ---          708          729 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.403      P=0.598N     P=0.225      P=0.601     |                                                    |
|POLY 3             |     P=0.275      P=0.508N     P=0.186      P=0.524     |                                                    |
|POLY 1.5           |     P=0.258      P=0.504N     P=0.183      P=0.515     |                                                    |
|POLY 6             |     P=0.309      P=0.517N     P=0.197      P=0.540     |                                                    |
|LOGISTIC REGRESSION|     P=0.379      (e)          P=0.225      P=0.601     |                                                    |
|COCH-ARM / FISHERS |     P=0.244      P=0.500N     P=0.187      P=0.508     |                                                    |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 15
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Adenoma                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.2%         2.7%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/19 (11%)   1/11 (9%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.069N     P=0.690N     P=0.215N     P=0.187N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.097N     P=0.518N     P=0.236N     P=0.227N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.099N     P=0.509N     P=0.239N     P=0.232N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.092N     P=0.537N     P=0.228N     P=0.218N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.069N     P=0.690N     (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.2%         2.7%         0.0%         0.0%        |2.3%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     2/19 (11%)   0/11 (0%)    0/21 (0%)    0/24 (0%)   |1/29 (3%)    1/27 (4%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     729 (T)      638          ---          ---         |730 (T)      730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.078N     P=0.639N     P=0.215N     P=0.187N    |P=0.287N     P=0.746      P=0.546N     P=0.564N     |
|POLY 3             |     P=0.097N     P=0.515N     P=0.236N     P=0.227N    |P=0.244N     P=0.760      P=0.518N     P=0.509N     |
|POLY 1.5           |     P=0.099N     P=0.507N     P=0.239N     P=0.232N    |P=0.241N     P=0.760N     P=0.511N     P=0.504N     |
|POLY 6             |     P=0.093N     P=0.530N     P=0.228N     P=0.218N    |P=0.248N     P=0.758      P=0.526N     P=0.518N     |
|LOGISTIC REGRESSION|     P=0.089N     P=0.547N     (e)          (e)         |P=0.287N     P=0.746      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.101N     P=0.500N     P=0.247N     P=0.247N    |P=0.235N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 16
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous                                                                      |
|     Tumor (benign, malignant or NOS), or Trichoepithelioma                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     10.4%        5.4%         0.0%         0.0%        |2.3%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     4/19 (21%)   1/11 (9%)    0/21 (0%)    0/24 (0%)   |1/29 (3%)    1/27 (4%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     729 (T)      638          ---          ---         |730 (T)      730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.009N**   P=0.570N     P=0.048N*    P=0.035N*   |P=0.287N     P=0.746      P=0.546N     P=0.564N     |
|POLY 3             |     P=0.015N*    P=0.355N     P=0.059N     P=0.054N    |P=0.244N     P=0.760      P=0.518N     P=0.509N     |
|POLY 1.5           |     P=0.016N*    P=0.346N     P=0.061N     P=0.057N    |P=0.241N     P=0.760N     P=0.511N     P=0.504N     |
|POLY 6             |     P=0.013N*    P=0.375N     P=0.054N     P=0.048N*   |P=0.248N     P=0.758      P=0.526N     P=0.518N     |
|LOGISTIC REGRESSION|     P=0.011N*    P=0.440N     (e)          (e)         |P=0.287N     P=0.746      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.018N*    P=0.339N     P=0.059N     P=0.059N    |P=0.235N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor                                                                       |
|     (M or B), Basal Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepitheliom                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   6/50 (12%)   8/50 (16%)   4/50 (8%)   |3/50 (6%)    1/50 (2%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     20.3%        15.8%        19.8%        9.8%        |6.9%         2.3%         0.0%         4.8%         |
|TERMINAL (d)       |     6/19 (32%)   1/11 (9%)    5/21 (24%)   3/24 (13%)  |2/29 (7%)    1/27 (4%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     529          579          340          617         |710          730 (T)      ---          695          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.070N     P=0.570      P=0.538N     P=0.097N    |P=0.569N     P=0.337N     P=0.172N     P=0.645N     |
|POLY 3             |     P=0.145N     P=0.410N     P=0.590N     P=0.156N    |P=0.457N     P=0.307N     P=0.135N     P=0.520N     |
|POLY 1.5           |     P=0.162N     P=0.398N     P=0.603N     P=0.167N    |P=0.452N     P=0.305N     P=0.129N     P=0.509N     |
|POLY 6             |     P=0.117N     P=0.431N     P=0.555N     P=0.136N    |P=0.465N     P=0.311N     P=0.143N     P=0.540N     |
|LOGISTIC REGRESSION|     P=0.156N     P=0.447N     P=0.606      P=0.138N    |P=0.516N     P=0.320N     P=0.153N     P=0.577N     |
|COCH-ARM / FISHERS |     P=0.178N     P=0.387N     P=0.607N     P=0.178N    |P=0.444N     P=0.309N     P=0.121N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 17
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    2/50 (4%)    4/50 (8%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     5.1%         5.4%         5.2%         9.9%        |0.0%         2.3%         0.0%         2.4%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    2/21 (10%)   3/24 (13%)  |0/29 (0%)    0/27 (0%)    0/23 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     646          617          729 (T)      638         |---          708          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.353      P=0.620      P=0.662N     P=0.425     |P=0.323      P=0.476      (e)          P=0.436      |
|POLY 3             |     P=0.241      P=0.680      P=0.693      P=0.355     |P=0.391      P=0.500      (e)          P=0.491      |
|POLY 1.5           |     P=0.231      P=0.687      P=0.690      P=0.346     |P=0.399      P=0.500      (e)          P=0.496      |
|POLY 6             |     P=0.263      P=0.665      P=0.689N     P=0.374     |P=0.378      P=0.498      (e)          P=0.482      |
|LOGISTIC REGRESSION|     P=0.260      P=0.689      P=0.676N     P=0.371     |P=0.368      P=0.498      (e)          P=0.436      |
|COCH-ARM / FISHERS |     P=0.221      P=0.691N     P=0.691N     P=0.339     |P=0.405      P=0.500      (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma,                                                                        |
|     or Fibrous Histiocytoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    3/50 (6%)    5/50 (10%)  |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     7.6%         5.4%         7.8%         12.2%       |0.0%         2.3%         0.0%         2.4%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    3/21 (14%)   3/24 (13%)  |0/29 (0%)    0/27 (0%)    0/23 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     609          617          729 (T)      576         |---          708          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.338      P=0.573N     P=0.627N     P=0.441     |P=0.323      P=0.476      (e)          P=0.436      |
|POLY 3             |     P=0.229      P=0.525N     P=0.656      P=0.379     |P=0.391      P=0.500      (e)          P=0.491      |
|POLY 1.5           |     P=0.217      P=0.512N     P=0.655      P=0.368     |P=0.399      P=0.500      (e)          P=0.496      |
|POLY 6             |     P=0.256      P=0.549N     P=0.664      P=0.401     |P=0.378      P=0.498      (e)          P=0.482      |
|LOGISTIC REGRESSION|     P=0.227      P=0.499N     P=0.655N     P=0.363     |P=0.368      P=0.498      (e)          P=0.436      |
|COCH-ARM / FISHERS |     P=0.205      P=0.500N     P=0.661N     P=0.357     |P=0.405      P=0.500      (e)          P=0.500      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 18
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Fibrosarcoma, Sarcoma, Myxosarcoma, or Fibrous Histiocytoma                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/50 (2%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         0.0%         2.6%         4.9%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    1/21 (5%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     609          ---          729 (T)      576         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.291      P=0.505N     P=0.749N     P=0.515     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.270      P=0.513N     P=0.759      P=0.518     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.258      P=0.506N     P=0.758      P=0.509     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.293      P=0.525N     P=0.759N     P=0.534     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.239      P=0.496N     P=0.762      P=0.480     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.247      P=0.500N     P=0.753N     P=0.500     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Keratoacanthoma                                                                                                             |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    3/50 (6%)    4/50 (8%)    3/50 (6%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.6%         8.0%         9.9%         7.4%        |4.6%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     2/19 (11%)   0/11 (0%)    1/21 (5%)    2/24 (8%)   |1/29 (3%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     529          579          340          617         |710          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.477N     P=0.563      P=0.529      P=0.590N    |P=0.153N     P=0.262N     P=0.301N     P=0.326N     |
|POLY 3             |     P=0.567N     P=0.645      P=0.515      P=0.647N    |P=0.115N     P=0.238N     P=0.258N     P=0.247N     |
|POLY 1.5           |     P=0.573      P=0.654      P=0.504      P=0.655N    |P=0.115N     P=0.237N     P=0.250N     P=0.242N     |
|POLY 6             |     P=0.536N     P=0.630      P=0.539      P=0.630N    |P=0.114N     P=0.241N     P=0.268N     P=0.258N     |
|LOGISTIC REGRESSION|     P=0.544      P=0.658N     P=0.530      P=0.654N    |P=0.132N     P=0.243N     P=0.273N     P=0.275N     |
|COCH-ARM / FISHERS |     P=0.558      P=0.661N     P=0.500      P=0.661N    |P=0.115N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 19
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Lipoma                                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         2.7%         5.2%         0.0%        |0.0%         0.0%         2.5%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    2/21 (10%)   0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     729 (T)      576          729 (T)      ---         |---          ---          589          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.285N     P=0.704      P=0.535      P=0.453N    |P=0.692      (e)          P=0.476      (e)          |
|POLY 3             |     P=0.348N     P=0.753      P=0.500      P=0.492N    |P=0.680      (e)          P=0.484      (e)          |
|POLY 1.5           |     P=0.358N     P=0.757      P=0.497      P=0.496N    |P=0.688      (e)          P=0.490      (e)          |
|POLY 6             |     P=0.328N     P=0.744      P=0.512      P=0.484N    |P=0.664      (e)          P=0.478      (e)          |
|LOGISTIC REGRESSION|     P=0.343N     P=0.762N     P=0.535      (e)         |P=0.719      (e)          P=0.564      (e)          |
|COCH-ARM / FISHERS |     P=0.366N     P=0.753N     P=0.500      P=0.500N    |P=0.694      (e)          P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         4.9%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          576         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.053      (e)          (e)          P=0.251     |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.049 *    (e)          (e)          P=0.251     |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.047 *    (e)          (e)          P=0.244     |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.054      (e)          (e)          P=0.264     |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.040 *    (e)          (e)          P=0.223     |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.046 *    (e)          (e)          P=0.247     |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 20
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    4/50 (8%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.6%         2.7%         10.3%        2.5%        |0.0%         0.0%         0.0%         4.8%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    4/21 (19%)   1/24 (4%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     708          723          729 (T)      729 (T)     |---          ---          ---          695          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.513N     P=0.673      P=0.211      P=0.711N    |P=0.031 *    (e)          (e)          P=0.179      |
|POLY 3             |     P=0.563      P=0.749      P=0.176      P=0.753N    |P=0.043 *    (e)          (e)          P=0.228      |
|POLY 1.5           |     P=0.544      P=0.755      P=0.175      P=0.757N    |P=0.044 *    (e)          (e)          P=0.233      |
|POLY 6             |     P=0.599      P=0.738      P=0.184      P=0.744N    |P=0.041 *    (e)          (e)          P=0.218      |
|LOGISTIC REGRESSION|     P=0.542N     P=0.713      P=0.210      P=0.728N    |P=0.040 *    (e)          (e)          P=0.212      |
|COCH-ARM / FISHERS |     P=0.526      P=0.753N     P=0.181      P=0.753N    |P=0.046 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, Squamous Cell                                                                           |
|     Carcinoma or Keratoacanthoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    8/50 (16%)   4/50 (8%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     10.2%        10.6%        19.8%        9.8%        |4.6%         0.0%         0.0%         4.8%         |
|TERMINAL (d)       |     2/19 (11%)   0/11 (0%)    5/21 (24%)   3/24 (13%)  |1/29 (3%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     529          579          340          617         |710          ---          ---          695          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.430N     P=0.500      P=0.220      P=0.547N    |P=0.398      P=0.262N     P=0.301N     P=0.569      |
|POLY 3             |     P=0.544      P=0.622      P=0.184      P=0.627N    |P=0.489      P=0.238N     P=0.258N     P=0.679      |
|POLY 1.5           |     P=0.520      P=0.633      P=0.178      P=0.635N    |P=0.494      P=0.237N     P=0.250N     P=0.687      |
|POLY 6             |     P=0.545N     P=0.602      P=0.201      P=0.607N    |P=0.482      P=0.241N     P=0.268N     P=0.663      |
|LOGISTIC REGRESSION|     P=0.513      P=0.634      P=0.177      P=0.622N    |P=0.455      P=0.243N     P=0.273N     P=0.646      |
|COCH-ARM / FISHERS |     P=0.500      P=0.643N     P=0.178      P=0.643N    |P=0.500      P=0.247N     P=0.247N     P=0.691N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 21
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma, Papilloma, or Keratoacanthoma                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    4/50 (8%)    8/50 (16%)   4/50 (8%)   |2/50 (4%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     10.2%        10.6%        19.8%        9.8%        |4.6%         0.0%         0.0%         4.8%         |
|TERMINAL (d)       |     2/19 (11%)   0/11 (0%)    5/21 (24%)   3/24 (13%)  |1/29 (3%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     529          579          340          617         |710          ---          ---          695          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.430N     P=0.500      P=0.220      P=0.547N    |P=0.398      P=0.262N     P=0.301N     P=0.569      |
|POLY 3             |     P=0.544      P=0.622      P=0.184      P=0.627N    |P=0.489      P=0.238N     P=0.258N     P=0.679      |
|POLY 1.5           |     P=0.520      P=0.633      P=0.178      P=0.635N    |P=0.494      P=0.237N     P=0.250N     P=0.687      |
|POLY 6             |     P=0.545N     P=0.602      P=0.201      P=0.607N    |P=0.482      P=0.241N     P=0.268N     P=0.663      |
|LOGISTIC REGRESSION|     P=0.513      P=0.634      P=0.177      P=0.622N    |P=0.455      P=0.243N     P=0.273N     P=0.646      |
|COCH-ARM / FISHERS |     P=0.500      P=0.643N     P=0.178      P=0.643N    |P=0.500      P=0.247N     P=0.247N     P=0.691N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Sebaceous Gland                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.2%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    1/21 (5%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          708          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.664      (e)          P=0.265      (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.626      (e)          P=0.237      (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.611      (e)          P=0.235      (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.655      (e)          P=0.245      (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.645      (e)          P=0.257      (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.595      (e)          P=0.247      (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 22
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     41/50 (82%)  42/50 (84%)  44/50 (88%)  41/50 (82%) |                                                    |
|POLY-3 ADJUSTED (b)|     89.9%        92.1%        93.4%        88.2%       |                                                    |
|TERMINAL (d)       |     19/19 (100%) 11/11 (100%) 21/21 (100%) 22/24 (92%) |                                                    |
|FIRST INCIDENCE    |     529          533          370          481         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.045N*    P=0.056      P=0.550N     P=0.183N    |                                                    |
|POLY 3             |     P=0.399N     P=0.501      P=0.386      P=0.529N    |                                                    |
|POLY 1.5           |     P=0.479N     P=0.502      P=0.321      P=0.567N    |                                                    |
|POLY 6             |     P=0.251N     P=0.529      P=0.551      P=0.445N    |                                                    |
|LOGISTIC REGRESSION|     P=0.512N     P=0.367      P=0.167      P=0.573N    |                                                    |
|COCH-ARM / FISHERS |     P=0.552      P=0.500      P=0.288      P=0.602N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   3/46 (7%)    7/48 (15%)   10/48 (21%) |6/50 (12%)   2/48 (4%)    5/49 (10%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     17.9%        8.7%         18.4%        25.5%       |13.8%        4.8%         12.6%        11.9%        |
|TERMINAL (d)       |     5/19 (26%)   1/11 (9%)    5/21 (24%)   9/24 (38%)  |3/29 (10%)   0/27 (0%)    3/23 (13%)   2/21 (10%)   |
|FIRST INCIDENCE    |     648          533          658          611         |688          701          694          612          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.324      P=0.360N     P=0.525N     P=0.478     |P=0.348      P=0.167N     P=0.591      P=0.567      |
|POLY 3             |     P=0.120      P=0.204N     P=0.597      P=0.292     |P=0.514      P=0.145N     P=0.564N     P=0.523N     |
|POLY 1.5           |     P=0.110      P=0.198N     P=0.584      P=0.278     |P=0.527      P=0.145N     P=0.543N     P=0.511N     |
|POLY 6             |     P=0.144      P=0.221N     P=0.611N     P=0.323     |P=0.490      P=0.146N     P=0.592N     P=0.549N     |
|LOGISTIC REGRESSION|     P=0.179      P=0.237N     P=0.585N     P=0.383     |P=0.475      P=0.146N     P=0.608N     P=0.542N     |
|COCH-ARM / FISHERS |     P=0.104      P=0.195N     P=0.581      P=0.266     |P=0.540      P=0.148N     P=0.514N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 23
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/46 (0%)    3/48 (6%)    2/48 (4%)   |0/50 (0%)    0/48 (0%)    2/49 (4%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     2.6%         0.0%         8.0%         5.2%        |0.0%         0.0%         5.0%         4.9%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    2/21 (10%)   2/24 (8%)   |0/29 (0%)    0/27 (0%)    1/23 (4%)    2/21 (10%)   |
|FIRST INCIDENCE    |     729 (T)      ---          703          729 (T)     |---          ---          649          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.379      P=0.609N     P=0.348      P=0.582     |P=0.057      (e)          P=0.203      P=0.170      |
|POLY 3             |     P=0.263      P=0.525N     P=0.295      P=0.501     |P=0.080      (e)          P=0.219      P=0.227      |
|POLY 1.5           |     P=0.249      P=0.521N     P=0.291      P=0.493     |P=0.084      (e)          P=0.224      P=0.232      |
|POLY 6             |     P=0.292      P=0.534N     P=0.307      P=0.517     |P=0.072      (e)          P=0.212      P=0.217      |
|LOGISTIC REGRESSION|     P=0.348      (e)          P=0.332      P=0.582     |P=0.075      (e)          P=0.224      P=0.170      |
|COCH-ARM / FISHERS |     P=0.237      P=0.521N     P=0.293      P=0.485     |P=0.089      (e)          P=0.242      P=0.247      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   3/46 (7%)    9/48 (19%)   11/48 (23%) |6/50 (12%)   2/48 (4%)    7/49 (14%)   6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     17.9%        8.7%         23.6%        28.1%       |13.8%        4.8%         17.5%        14.3%        |
|TERMINAL (d)       |     5/19 (26%)   1/11 (9%)    6/21 (29%)   10/24 (42%) |3/29 (10%)   0/27 (0%)    4/23 (17%)   3/21 (14%)   |
|FIRST INCIDENCE    |     648          533          658          611         |688          701          649          612          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.237      P=0.360N     P=0.491      P=0.382     |P=0.199      P=0.167N     P=0.340      P=0.427      |
|POLY 3             |     P=0.066      P=0.204N     P=0.370      P=0.208     |P=0.341      P=0.145N     P=0.435      P=0.598      |
|POLY 1.5           |     P=0.060      P=0.198N     P=0.359      P=0.198     |P=0.356      P=0.145N     P=0.455      P=0.610      |
|POLY 6             |     P=0.084      P=0.221N     P=0.400      P=0.234     |P=0.315      P=0.146N     P=0.409      P=0.573      |
|LOGISTIC REGRESSION|     P=0.113      P=0.237N     P=0.425      P=0.293     |P=0.307      P=0.146N     P=0.396      P=0.572      |
|COCH-ARM / FISHERS |     P=0.057      P=0.195N     P=0.359      P=0.190     |P=0.371      P=0.148N     P=0.484      P=0.620N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 24
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/46 (0%)    0/48 (0%)    3/48 (6%)   |1/50 (2%)    0/48 (0%)    0/49 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.6%         0.0%         0.0%         7.7%        |2.3%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    0/21 (0%)    3/24 (13%)  |1/29 (3%)    0/27 (0%)    0/23 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     729 (T)      ---          ---          729 (T)     |730 (T)      ---          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.159      P=0.609N     P=0.480N     P=0.390     |P=0.527      P=0.514N     P=0.546N     P=0.689      |
|POLY 3             |     P=0.089      P=0.525N     P=0.505N     P=0.305     |P=0.587      P=0.507N     P=0.518N     P=0.751      |
|POLY 1.5           |     P=0.086      P=0.521N     P=0.508N     P=0.298     |P=0.591      P=0.507N     P=0.512N     P=0.756      |
|POLY 6             |     P=0.095      P=0.534N     P=0.499N     P=0.321     |P=0.579      P=0.508N     P=0.526N     P=0.741      |
|LOGISTIC REGRESSION|     P=0.159      (e)          (e)          P=0.390     |P=0.527      (e)          (e)          P=0.689      |
|COCH-ARM / FISHERS |     P=0.085      P=0.521N     P=0.510N     P=0.293     |P=0.597      P=0.510N     P=0.505N     P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/46 (0%)    1/48 (2%)    3/48 (6%)   |2/50 (4%)    0/48 (0%)    0/49 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     5.2%         0.0%         2.7%         7.7%        |4.6%         0.0%         0.0%         4.8%         |
|TERMINAL (d)       |     2/19 (11%)   0/11 (0%)    1/21 (5%)    3/24 (13%)  |2/29 (7%)    0/27 (0%)    0/23 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     729 (T)      ---          729 (T)      729 (T)     |730 (T)      ---          ---          662          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.385      P=0.364N     P=0.465N     P=0.608     |P=0.425      P=0.254N     P=0.290N     P=0.605      |
|POLY 3             |     P=0.255      P=0.265N     P=0.509N     P=0.501     |P=0.492      P=0.245N     P=0.258N     P=0.680      |
|POLY 1.5           |     P=0.245      P=0.260N     P=0.514N     P=0.491     |P=0.497      P=0.245N     P=0.251N     P=0.687      |
|POLY 6             |     P=0.275      P=0.275N     P=0.498N     P=0.522     |P=0.485      P=0.246N     P=0.266N     P=0.666      |
|LOGISTIC REGRESSION|     P=0.385      (e)          P=0.465N     P=0.608     |P=0.465      (e)          (e)          P=0.655      |
|COCH-ARM / FISHERS |     P=0.237      P=0.269N     P=0.515N     P=0.480     |P=0.503      P=0.258N     P=0.253N     P=0.691N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 25
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Urinary Bladder                                                                                                                  |
|     Papilloma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/49 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.3%         0.0%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/18 (6%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     687          ---          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.090N     P=0.325N     P=0.211N     P=0.190N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.108N     P=0.243N     P=0.231N     P=0.223N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.110N     P=0.237N     P=0.234N     P=0.228N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.103N     P=0.255N     P=0.223N     P=0.213N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.098N     P=0.268N     P=0.216N     P=0.205N    |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.113N     P=0.242N     P=0.242N     P=0.242N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |6/50 (12%)   3/50 (6%)    6/50 (12%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |13.7%        7.0%         15.2%        4.8%         |
|TERMINAL (d)       |                                                        |5/29 (17%)   3/27 (11%)   5/23 (22%)   1/21 (5%)    |
|FIRST INCIDENCE    |                                                        |554          730 (T)      705          662          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.298N     P=0.272N     P=0.458      P=0.226N     |
|POLY 3             |                                                        |P=0.182N     P=0.249N     P=0.549      P=0.149N     |
|POLY 1.5           |                                                        |P=0.173N     P=0.245N     P=0.576      P=0.141N     |
|POLY 6             |                                                        |P=0.202N     P=0.257N     P=0.517      P=0.164N     |
|LOGISTIC REGRESSION|                                                        |P=0.216N     P=0.247N     P=0.525      P=0.147N     |
|COCH-ARM / FISHERS |                                                        |P=0.162N     P=0.243N     P=0.620N     P=0.134N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 26
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.5%         2.7%         5.1%         0.0%        |0.0%         2.3%         0.0%         2.4%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     520          652          617          ---         |---          691          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.329N     P=0.758      P=0.502      P=0.521N    |P=0.347      P=0.494      (e)          P=0.436      |
|POLY 3             |     P=0.352N     P=0.748      P=0.499      P=0.495N    |P=0.391      P=0.500      (e)          P=0.491      |
|POLY 1.5           |     P=0.360N     P=0.754      P=0.496      P=0.498N    |P=0.399      P=0.501      (e)          P=0.496      |
|POLY 6             |     P=0.335N     P=0.736      P=0.510      P=0.489N    |P=0.378      P=0.498      (e)          P=0.482      |
|LOGISTIC REGRESSION|     P=0.374N     P=0.764      P=0.518      P=0.545N    |P=0.382      P=0.500      (e)          P=0.436      |
|COCH-ARM / FISHERS |     P=0.366N     P=0.753N     P=0.500      P=0.500N    |P=0.405      P=0.500      (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear, or                                                                           |
|     Undifferentiated                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     29/50 (58%)  31/50 (62%)  33/50 (66%)  30/50 (60%) |18/50 (36%)  21/50 (42%)  23/50 (46%)  24/50 (48%)  |
|POLY-3 ADJUSTED (b)|     63.6%        69.4%        73.5%        64.6%       |38.5%        44.3%        51.5%        51.2%        |
|TERMINAL (d)       |     11/19 (58%)  6/11 (55%)   14/21 (67%)  11/24 (46%) |9/29 (31%)   7/27 (26%)   8/23 (35%)   5/21 (24%)   |
|FIRST INCIDENCE    |     354          533          387          444         |400          495          390          533          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.174N     P=0.136      P=0.446      P=0.366N    |P=0.059      P=0.320      P=0.107      P=0.086      |
|POLY 3             |     P=0.541      P=0.352      P=0.204      P=0.547     |P=0.117      P=0.358      P=0.145      P=0.149      |
|POLY 1.5           |     P=0.499      P=0.378      P=0.213      P=0.518     |P=0.122      P=0.352      P=0.162      P=0.150      |
|POLY 6             |     P=0.459N     P=0.328      P=0.232      P=0.571N    |P=0.116      P=0.364      P=0.136      P=0.150      |
|LOGISTIC REGRESSION|     P=0.486      P=0.420      P=0.258      P=0.489     |P=0.165      P=0.333      P=0.256      P=0.191      |
|COCH-ARM / FISHERS |     P=0.471      P=0.419      P=0.268      P=0.500     |P=0.133      P=0.341      P=0.208      P=0.156      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 27
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Benign, Malignant, NOS                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    4/50 (8%)    2/50 (4%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.6%         2.7%         10.1%        4.9%        |0.0%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    2/21 (10%)   0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     597          652          461          589         |---          ---          ---          685          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.403      P=0.755      P=0.202      P=0.532     |P=0.183      (e)          (e)          P=0.471      |
|POLY 3             |     P=0.349      P=0.749      P=0.181      P=0.516     |P=0.193      (e)          (e)          P=0.492      |
|POLY 1.5           |     P=0.330      P=0.755      P=0.178      P=0.508     |P=0.196      (e)          (e)          P=0.496      |
|POLY 6             |     P=0.387      P=0.737      P=0.192      P=0.531     |P=0.188      (e)          (e)          P=0.483      |
|LOGISTIC REGRESSION|     P=0.302      P=0.757N     P=0.185      P=0.486     |P=0.197      (e)          (e)          P=0.499      |
|COCH-ARM / FISHERS |     P=0.313      P=0.753N     P=0.181      P=0.500     |P=0.198      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma: Malignant                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    3/50 (6%)    1/50 (2%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         7.6%         2.5%        |0.0%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    1/21 (5%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          461          589         |---          ---          ---          685          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.294      (e)          P=0.137      P=0.505     |P=0.183      (e)          (e)          P=0.471      |
|POLY 3             |     P=0.279      (e)          P=0.122      P=0.511     |P=0.193      (e)          (e)          P=0.492      |
|POLY 1.5           |     P=0.262      (e)          P=0.119      P=0.505     |P=0.196      (e)          (e)          P=0.496      |
|POLY 6             |     P=0.314      (e)          P=0.130      P=0.520     |P=0.188      (e)          (e)          P=0.483      |
|LOGISTIC REGRESSION|     P=0.232      (e)          P=0.128      P=0.484     |P=0.197      (e)          (e)          P=0.499      |
|COCH-ARM / FISHERS |     P=0.247      (e)          P=0.121      P=0.500     |P=0.198      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 28
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     49/50 (98%)  49/50 (98%)  49/50 (98%)  49/50 (98%) |42/50 (84%)  43/50 (86%)  40/50 (80%)  37/50 (74%)  |
|POLY-3 ADJUSTED (b)|     99.8%        99.5%        98.7%        99.5%       |88.1%        91.3%        88.9%        78.9%        |
|TERMINAL (d)       |     19/19 (100%) 11/11 (100%) 21/21 (100%) 24/24 (100%)|25/29 (86%)  25/27 (93%)  21/23 (91%)  17/21 (81%)  |
|FIRST INCIDENCE    |     520          479          340          481         |508          584          462          462          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.055N     P=0.095      P=0.384N     P=0.193N    |P=0.271      P=0.361      P=0.217      P=0.323      |
|POLY 3             |     P=0.748N     P=0.999N     P=0.771N     P=1.000N    |P=0.059N     P=0.418      P=0.588      P=0.163N     |
|POLY 1.5           |     P=0.666N     P=0.910N     P=0.734N     P=0.928N    |P=0.063N     P=0.462      P=0.581N     P=0.156N     |
|POLY 6             |     P=0.918N     P=1.000N     P=0.933N     P=1.000N    |P=0.068N     P=0.361      P=0.494      P=0.191N     |
|LOGISTIC REGRESSION|     P=0.651N     (e)          P=0.674      (e)         |P=0.107N     P=0.543      P=0.545      P=0.187N     |
|COCH-ARM / FISHERS |     P=0.634      P=0.753N     P=0.753N     P=0.753N    |P=0.080N     P=0.500      P=0.398N     P=0.163N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     41/50 (82%)  40/50 (80%)  41/50 (82%)  38/50 (76%) |26/50 (52%)  26/50 (52%)  30/50 (60%)  32/50 (64%)  |
|POLY-3 ADJUSTED (b)|     85.5%        84.9%        88.4%        80.1%       |54.7%        54.1%        63.2%        67.1%        |
|TERMINAL (d)       |     16/19 (84%)  8/11 (73%)   17/21 (81%)  16/24 (67%) |14/29 (48%)  9/27 (33%)   9/23 (39%)   9/21 (43%)   |
|FIRST INCIDENCE    |     354          465          387          444         |400          495          247          533          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.046N*    P=0.166      P=0.403N     P=0.141N    |P=0.038 *    P=0.496      P=0.127      P=0.063      |
|POLY 3             |     P=0.270N     P=0.588N     P=0.455      P=0.328N    |P=0.085      P=0.555N     P=0.261      P=0.148      |
|POLY 1.5           |     P=0.282N     P=0.548N     P=0.490      P=0.328N    |P=0.086      P=0.566N     P=0.260      P=0.147      |
|POLY 6             |     P=0.222N     P=0.628      P=0.477      P=0.300N    |P=0.090      P=0.539N     P=0.278      P=0.158      |
|LOGISTIC REGRESSION|     P=0.248N     P=0.505N     P=0.567      P=0.306N    |P=0.130      P=0.579N     P=0.379      P=0.180      |
|COCH-ARM / FISHERS |     P=0.275N     P=0.500N     P=0.602N     P=0.312N    |P=0.096      P=0.579N     P=0.273      P=0.156      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 29
                     Statistical Analysis of Primary Tumors in Rats(FISCHER 344)       -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |     #            #            #            #           |#            #            #            #            |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     50/50 (100%) 50/50 (100%) 50/50 (100%) 50/50 (100%)|47/50 (94%)  48/50 (96%)  50/50 (100%) 48/50 (96%)  |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       100.0%       100.0%      |94.0%        96.0%        100.0%       97.4%        |
|TERMINAL (d)       |     19/19 (100%) 11/11 (100%) 21/21 (100%) 24/24 (100%)|26/29 (90%)  25/27 (93%)  23/23 (100%) 20/21 (95%)  |
|FIRST INCIDENCE    |     354          465          340          444         |400          495          247          462          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.049 *    P=0.375      P=0.064      P=0.078      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.212      P=0.500      P=0.119      P=0.363      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.263      P=0.500      P=0.119      P=0.411      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.177      P=0.500      P=0.119      P=0.326      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.386      (e)          (e)          P=0.496      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.373      P=0.500      P=0.121      P=0.500      |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).