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TDMS Study 05197-11 Pathology Tables

NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10
LAB: Battelle Northwest                                     2-BUTOXYETHANOL                                    DATE: 02/23/98

EXPERIMENT: 05197 TEST: 11                                                                                     TIME: 09:02:49
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:
CONT: NO1-ES-15318                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 62077D
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 111-76-0002
NTP                                    STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS                          REPORT: PEIRPT10   
LAB: Battelle Northwest                                     2-BUTOXYETHANOL                                    DATE: 02/23/98     
EXPERIMENT: 05197 TEST: 11                                                                                     TIME: 09:02:49     
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:              
CONT: NO1-ES-15318                              ROUTE: RESPIRATORY EXPOSURE WHOLE BODY                         NTP C#: 62077D     
PATHOLOGIST: GRUMBEIN, S.                                                                                      CAS: 111-76-0002   



SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF                 2-BUTOXYETHANOL
===============================================================

Male Rats
------------
Organ                                 Morphology
-----                                 ----------
Adrenal Cortex                         Hyperplasia
Heart                                  Cardiomyopathy
Heart: Atrium                          Thrombosis
Kidney                                 Infarct
Liver                                  Degeneration Cystic
Liver: Kupffer Cell                    Pigmentation
Lung: Alveolar Epithelium              Hyperplasia
Nose: Olfactory Epithelium             Degeneration Hyaline
Spleen                                 Fibrosis
Stomach, Forestomach                   Ulcer
Thyroid Gland: C-Cell                  Hyperplasia
===============================================================
Female Rats
------------
Organ                                  Morphology
-----                                  ----------
Adrenal Cortex                         Degeneration Cystic
                                       Hypertrophy
                                       Vacuolization Cytoplasmic
Adrenal Medulla                        Hyperplasia
Clitoral Gland                         Hyperplasia
Kidney: Renal Tubule                   Necrosis
Liver                                  Eosinophilic Focus
                                       Hematopoietic Cell Proliferation
                                       Hepatodiaphragmatic Nodule
Liver: Kupffer Cell                    Pigmentation
Lung: Alveolar Epithelium              Hyperplasia
Nose: Olfactory Epithelium             Degeneration Hyaline
Pituitary Gland: Pars Distalis         Hyperplasia
Spleen                                 Hematopoietic Cell Proliferation
                                       Pigmentation Hemosiderin
Stomach, Glandular                     Mineralization
Thyroid Gland: C-Cell                  Hyperplasia
===============================================================
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 1
                     Statistical Analysis of Non-neoplastic Lesions in        Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    3/49 (6%)    2/50 (4%)   |0/50 (0%)    1/50 (2%)    1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         0.0%         7.8%         5.0%        |0.0%         2.3%         2.5%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    2/21 (10%)   1/24 (4%)   |0/29 (0%)    0/27 (0%)    1/23 (4%)    0/21 (0%)    |
|FIRST INCIDENCE    |     642          ---          701          694         |---          701          730 (T)      ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.358      P=0.519N     P=0.345      P=0.562     |P=0.665N     P=0.488      P=0.454      (e)          |
|POLY 3             |     P=0.267      P=0.512N     P=0.300      P=0.513     |P=0.609N     P=0.500      P=0.482      (e)          |
|POLY 1.5           |     P=0.254      P=0.506N     P=0.297      P=0.506     |P=0.601N     P=0.500      P=0.489      (e)          |
|POLY 6             |     P=0.296      P=0.524N     P=0.311      P=0.526     |P=0.622N     P=0.498      P=0.474      (e)          |
|LOGISTIC REGRESSION|     P=0.290      P=0.497N     P=0.314      P=0.515     |P=0.625N     P=0.500      P=0.454      (e)          |
|COCH-ARM / FISHERS |     P=0.241      P=0.500N     P=0.301      P=0.500     |P=0.595N     P=0.500      P=0.500      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    0/49 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |0.0%         2.3%         0.0%         7.3%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    2/21 (10%)   |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |---          722          ---          701          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.023 *    P=0.500      (e)          P=0.071      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.039 *    P=0.500      (e)          P=0.111      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.041 *    P=0.500      (e)          P=0.115      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.036 *    P=0.497      (e)          P=0.103      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.030 *    P=0.493      (e)          P=0.087      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.044 *    P=0.500      (e)          P=0.121      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 2
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     23/50 (46%)  27/50 (54%)  25/49 (51%)  30/50 (60%) |28/50 (56%)  24/50 (48%)  19/50 (38%)  20/50 (40%)  |
|POLY-3 ADJUSTED (b)|     54.1%        62.6%        60.9%        67.8%       |61.6%        54.7%        44.8%        46.0%        |
|TERMINAL (d)       |     11/19 (58%)  10/11 (91%)  16/21 (76%)  20/24 (83%) |20/29 (69%)  21/27 (78%)  10/23 (44%)  12/21 (57%)  |
|FIRST INCIDENCE    |     529          465          549          481         |558          617          496          571          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.400N     P=0.041 *    P=0.570N     P=0.399     |P=0.382N     P=0.380N     P=0.267N     P=0.423N     |
|POLY 3             |     P=0.123      P=0.268      P=0.334      P=0.124     |P=0.065N     P=0.322N     P=0.079N     P=0.095N     |
|POLY 1.5           |     P=0.118      P=0.279      P=0.342      P=0.119     |P=0.061N     P=0.293N     P=0.069N     P=0.085N     |
|POLY 6             |     P=0.141      P=0.229      P=0.353      P=0.134     |P=0.078N     P=0.386N     P=0.092N     P=0.123N     |
|LOGISTIC REGRESSION|     P=0.158      P=0.235      P=0.405      P=0.136     |P=0.095N     P=0.277N     P=0.097N     P=0.111N     |
|COCH-ARM / FISHERS |     P=0.118      P=0.274      P=0.383      P=0.115     |P=0.059N     P=0.274N     P=0.054N     P=0.080N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Hypertrophy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   7/50 (14%)   8/49 (16%)   4/50 (8%)   |18/50 (36%)  11/50 (22%)  9/50 (18%)   7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     17.6%        18.3%        19.9%        9.8%        |40.8%        24.9%        22.1%        16.8%        |
|TERMINAL (d)       |     1/19 (5%)    2/11 (18%)   4/21 (19%)   3/24 (13%)  |14/29 (48%)  7/27 (26%)   3/23 (13%)   5/21 (24%)   |
|FIRST INCIDENCE    |     631          561          561          534         |575          638          390          617          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.111N     P=0.422      P=0.565      P=0.187N    |P=0.057N     P=0.130N     P=0.131N     P=0.063N     |
|POLY 3             |     P=0.187N     P=0.582      P=0.506      P=0.243N    |P=0.010N*    P=0.082N     P=0.048N*    P=0.011N*    |
|POLY 1.5           |     P=0.203N     P=0.599      P=0.490      P=0.252N    |P=0.009N**   P=0.085N     P=0.042N*    P=0.009N**   |
|POLY 6             |     P=0.163N     P=0.547      P=0.539      P=0.230N    |P=0.013N*    P=0.081N     P=0.056N     P=0.014N*    |
|LOGISTIC REGRESSION|     P=0.203N     P=0.579      P=0.485      P=0.245N    |P=0.013N*    P=0.093N     P=0.059N     P=0.018N*    |
|COCH-ARM / FISHERS |     P=0.219N     P=0.613N     P=0.483      P=0.262N    |P=0.009N**   P=0.093N     P=0.035N*    P=0.010N*    |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 3
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    1/49 (2%)    1/50 (2%)   |0/50 (0%)    3/50 (6%)    4/50 (8%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.6%         0.0%         2.5%         2.5%        |0.0%         6.8%         9.8%         7.2%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     638          ---          370          617         |---          495          529          610          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.553      P=0.524N     P=0.760      P=0.748N    |P=0.143      P=0.128      P=0.055      P=0.107      |
|POLY 3             |     P=0.563      P=0.512N     P=0.759N     P=0.752N    |P=0.146      P=0.123      P=0.053      P=0.113      |
|POLY 1.5           |     P=0.550      P=0.506N     P=0.759      P=0.756N    |P=0.154      P=0.122      P=0.055      P=0.116      |
|POLY 6             |     P=0.587      P=0.524N     P=0.752N     P=0.743N    |P=0.133      P=0.123      P=0.052      P=0.107      |
|LOGISTIC REGRESSION|     P=0.527      P=0.496N     P=0.701N     P=0.754     |P=0.177      P=0.076      P=0.082      P=0.124      |
|COCH-ARM / FISHERS |     P=0.538      P=0.500N     P=0.747      P=0.753N    |P=0.162      P=0.121      P=0.059      P=0.121      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Vacuolization Cytoplasmic                                                                                                   |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    4/49 (8%)    4/50 (8%)   |7/50 (14%)   9/50 (18%)   1/50 (2%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     5.1%         5.4%         10.4%        9.7%        |16.0%        20.4%        2.5%         12.0%        |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    2/21 (10%)   2/24 (8%)   |4/29 (14%)   5/27 (19%)   1/23 (4%)    2/21 (10%)   |
|FIRST INCIDENCE    |     683          652          694          576         |652          564          730 (T)      617          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.362      P=0.606      P=0.391      P=0.419     |P=0.315N     P=0.355      P=0.066N     P=0.573N     |
|POLY 3             |     P=0.243      P=0.678      P=0.332      P=0.361     |P=0.182N     P=0.399      P=0.041N*    P=0.410N     |
|POLY 1.5           |     P=0.226      P=0.686      P=0.327      P=0.349     |P=0.170N     P=0.399      P=0.037N*    P=0.394N     |
|POLY 6             |     P=0.277      P=0.661      P=0.347      P=0.384     |P=0.205N     P=0.393      P=0.048N*    P=0.444N     |
|LOGISTIC REGRESSION|     P=0.247      P=0.666      P=0.364      P=0.347     |P=0.192N     P=0.391      P=0.047N*    P=0.431N     |
|COCH-ARM / FISHERS |     P=0.210      P=0.691N     P=0.329      P=0.339     |P=0.160N     P=0.393      P=0.030N*    P=0.380N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 4
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     24/50 (48%)  22/50 (44%)  31/49 (63%)  27/50 (54%) |11/50 (22%)  11/50 (22%)  8/49 (16%)   17/49 (35%)  |
|POLY-3 ADJUSTED (b)|     56.2%        53.4%        71.8%        60.5%       |25.0%        24.9%        19.8%        39.6%        |
|TERMINAL (d)       |     11/19 (58%)  6/11 (55%)   16/21 (76%)  16/24 (67%) |7/29 (24%)   7/27 (26%)   2/22 (9%)    7/21 (33%)   |
|FIRST INCIDENCE    |     529          533          484          444         |554          495          583          533          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.333N     P=0.274      P=0.255      P=0.481N    |P=0.030 *    P=0.537      P=0.493N     P=0.046 *    |
|POLY 3             |     P=0.270      P=0.487N     P=0.084      P=0.418     |P=0.067      P=0.594N     P=0.375N     P=0.106      |
|POLY 1.5           |     P=0.227      P=0.451N     P=0.078      P=0.384     |P=0.072      P=0.591N     P=0.359N     P=0.112      |
|POLY 6             |     P=0.358      P=0.550N     P=0.114      P=0.478     |P=0.061      P=0.593      P=0.388N     P=0.095      |
|LOGISTIC REGRESSION|     P=0.243      P=0.495N     P=0.085      P=0.381     |P=0.069      P=0.593      P=0.363N     P=0.099      |
|COCH-ARM / FISHERS |     P=0.191      P=0.421N     P=0.092      P=0.345     |P=0.081      P=0.595N     P=0.323N     P=0.119      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Blood Vessel: Aorta                                                                                                              |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/0 (0%)     2/2 (100%)   0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     0.0%         100.0%       0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     ---          722          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 5
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Fibrous Osteodystrophy                                                                                                      |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    3/50 (6%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         8.2%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    1/11 (9%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     729 (T)      722          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.102N     P=0.166      P=0.480N     P=0.453N    |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.147N     P=0.286      P=0.500N     P=0.492N    |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.149N     P=0.296      P=0.502N     P=0.496N    |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.143N     P=0.267      P=0.493N     P=0.484N    |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.104N     P=0.183      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.153N     P=0.309      P=0.500N     P=0.500N    |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Hyperostosis                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/50 (0%)    2/50 (4%)    2/50 (4%)   |9/50 (18%)   10/50 (20%)  8/50 (16%)   9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         5.1%         4.9%        |20.5%        22.4%        20.0%        21.2%        |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |5/29 (17%)   6/27 (22%)   4/23 (17%)   4/21 (19%)   |
|FIRST INCIDENCE    |     ---          ---          561          628         |652          495          691          610          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.111      (e)          P=0.235      P=0.275     |P=0.352      P=0.451      P=0.515      P=0.395      |
|POLY 3             |     P=0.099      (e)          P=0.242      P=0.248     |P=0.549N     P=0.517      P=0.584N     P=0.575      |
|POLY 1.5           |     P=0.092      (e)          P=0.238      P=0.243     |P=0.526N     P=0.513      P=0.553N     P=0.590      |
|POLY 6             |     P=0.114      (e)          P=0.253      P=0.259     |P=0.514      P=0.513      P=0.596      P=0.545      |
|LOGISTIC REGRESSION|     P=0.080      (e)          P=0.258      P=0.240     |P=0.547      P=0.500      P=0.599      P=0.556      |
|COCH-ARM / FISHERS |     P=0.086      (e)          P=0.247      P=0.247     |P=0.500N     P=0.500      P=0.500N     P=0.602N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 6
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone Marrow                                                                                                                      |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   4/50 (8%)    4/50 (8%)    6/49 (12%)  |5/50 (10%)   4/50 (8%)    3/50 (6%)    7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     12.8%        10.5%        10.0%        14.9%       |11.4%        9.3%         7.4%         16.8%        |
|TERMINAL (d)       |     3/19 (16%)   0/11 (0%)    1/21 (5%)    3/24 (13%)  |2/29 (7%)    3/27 (11%)   0/23 (0%)    4/21 (19%)   |
|FIRST INCIDENCE    |     673          465          461          576         |558          691          583          663          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.559N     P=0.588      P=0.452N     P=0.620N    |P=0.153      P=0.529N     P=0.450N     P=0.221      |
|POLY 3             |     P=0.416      P=0.514N     P=0.482N     P=0.526     |P=0.239      P=0.513N     P=0.405N     P=0.340      |
|POLY 1.5           |     P=0.394      P=0.505N     P=0.495N     P=0.506     |P=0.254      P=0.505N     P=0.387N     P=0.360      |
|POLY 6             |     P=0.459      P=0.534N     P=0.455N     P=0.562     |P=0.216      P=0.527N     P=0.425N     P=0.305      |
|LOGISTIC REGRESSION|     P=0.378      P=0.521N     P=0.503N     P=0.526     |P=0.249      P=0.500N     P=0.336N     P=0.350      |
|COCH-ARM / FISHERS |     P=0.374      P=0.500N     P=0.500N     P=0.486     |P=0.270      P=0.500N     P=0.357N     P=0.380      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral Gland                                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |7/46 (15%)   4/45 (9%)    2/44 (5%)    2/48 (4%)    |
|POLY-3 ADJUSTED (b)|                                                        |17.2%        10.2%        5.9%         5.0%         |
|TERMINAL (d)       |                                                        |4/27 (15%)   2/23 (9%)    1/20 (5%)    1/20 (5%)    |
|FIRST INCIDENCE    |                                                        |554          564          688          571          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.092N     P=0.327N     P=0.162N     P=0.162N     |
|POLY 3             |                                                        |P=0.048N*    P=0.281N     P=0.127N     P=0.080N     |
|POLY 1.5           |                                                        |P=0.045N*    P=0.276N     P=0.111N     P=0.074N     |
|POLY 6             |                                                        |P=0.055N     P=0.292N     P=0.147N     P=0.093N     |
|LOGISTIC REGRESSION|                                                        |P=0.045N*    P=0.273N     P=0.125N     P=0.073N     |
|COCH-ARM / FISHERS |                                                        |P=0.042N*    P=0.274N     P=0.090N     P=0.070N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 7
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye                                                                                                                              |
|     Cataract                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/2 (100%)   0/0 (0%)     2/2 (100%)   1/1 (100%)  |0/0 (0%)     5/7 (71%)    2/3 (67%)    1/1 (100%)   |
|POLY-3 ADJUSTED (b)|     100.0%       0.0%         100.0%       100.0%      |0.0%         71.8%        79.5%        100.0%       |
|TERMINAL (d)       |     1/1 (100%)   0/0 (0%)     1/1 (100%)   1/1 (100%)  |0/0 (0%)     4/5 (80%)    1/1 (100%)   0/0 (0%)     |
|FIRST INCIDENCE    |     617          ---          718          729 (T)     |---          708          496          571          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.339      P=0.507      P=0.491      (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=1.000      P=1.000      P=1.000      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=1.000      P=1.000      P=1.000      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=1.000      P=1.000      P=1.000      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.657      (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.609      P=1.000      P=1.000      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Eye: Retina                                                                                                                      |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/2 (100%)   0/0 (0%)     2/2 (100%)   1/1 (100%)  |0/0 (0%)     5/7 (71%)    1/3 (33%)    1/1 (100%)   |
|POLY-3 ADJUSTED (b)|     100.0%       0.0%         100.0%       100.0%      |0.0%         71.8%        54.6%        100.0%       |
|TERMINAL (d)       |     1/1 (100%)   0/0 (0%)     1/1 (100%)   1/1 (100%)  |0/0 (0%)     4/5 (80%)    1/1 (100%)   0/0 (0%)     |
|FIRST INCIDENCE    |     617          ---          718          729 (T)     |---          708          730 (T)      571          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.346      P=0.507      P=1.000N     (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=1.000N     P=1.000N     P=1.000      (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=1.000N     P=1.000N     P=1.000      (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=1.000N     P=1.000N     P=1.000      (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.276      (e)          P=1.000N     (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.718      P=1.000      P=1.000      (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 8
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Cardiomyopathy                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     42/50 (84%)  44/50 (88%)  39/50 (78%)  41/50 (82%) |34/50 (68%)  31/50 (62%)  34/50 (68%)  30/50 (60%)  |
|POLY-3 ADJUSTED (b)|     89.5%        93.1%        87.8%        89.4%       |74.0%        67.2%        78.9%        67.8%        |
|TERMINAL (d)       |     18/19 (95%)  11/11 (100%) 20/21 (95%)  24/24 (100%)|25/29 (86%)  21/27 (78%)  21/23 (91%)  20/21 (95%)  |
|FIRST INCIDENCE    |     354          465          370          495         |508          495          496          472          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.023N*    P=0.054      P=0.223N     P=0.146N    |P=0.144      P=0.489N     P=0.128      P=0.244      |
|POLY 3             |     P=0.461N     P=0.377      P=0.537N     P=0.655N    |P=0.387N     P=0.305N     P=0.371      P=0.327N     |
|POLY 1.5           |     P=0.402N     P=0.381      P=0.450N     P=0.585N    |P=0.333N     P=0.315N     P=0.448      P=0.292N     |
|POLY 6             |     P=0.540N     P=0.373      P=0.598N     P=0.650     |P=0.495N     P=0.299N     P=0.298      P=0.409N     |
|LOGISTIC REGRESSION|     P=0.264N     P=0.343      P=0.388N     P=0.456N    |P=0.396N     P=0.327N     P=0.314      P=0.346N     |
|COCH-ARM / FISHERS |     P=0.328N     P=0.387      P=0.306N     P=0.500N    |P=0.283N     P=0.338N     P=0.585N     P=0.266N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Artery                                                                                                                    |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          722          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.330N     P=0.168      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.405N     P=0.225      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.405N     P=0.232      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.405N     P=0.213      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.346N     P=0.170      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 9
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart: Atrium                                                                                                                    |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    6/50 (12%)   4/50 (8%)    3/50 (6%)   |1/50 (2%)    2/50 (4%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         15.9%        10.0%        7.3%        |2.3%         4.6%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     718          627          461          628         |688          495          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.543N     P=0.034 *    P=0.199      P=0.372     |P=0.220N     P=0.489      P=0.523N     P=0.530N     |
|POLY 3             |     P=0.511      P=0.049 *    P=0.188      P=0.326     |P=0.198N     P=0.504      P=0.519N     P=0.510N     |
|POLY 1.5           |     P=0.486      P=0.053      P=0.182      P=0.315     |P=0.193N     P=0.504      P=0.512N     P=0.505N     |
|POLY 6             |     P=0.559      P=0.044 *    P=0.205      P=0.346     |P=0.207N     P=0.502      P=0.527N     P=0.520N     |
|LOGISTIC REGRESSION|     P=0.465      P=0.044 *    P=0.186      P=0.311     |P=0.169N     P=0.466      P=0.510N     P=0.502N     |
|COCH-ARM / FISHERS |     P=0.463      P=0.056      P=0.181      P=0.309     |P=0.188N     P=0.500      P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Cecum                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/46 (13%)   7/47 (15%)   4/47 (9%)    5/46 (11%)  |8/47 (17%)   6/49 (12%)   4/48 (8%)    5/48 (10%)   |
|POLY-3 ADJUSTED (b)|     16.1%        19.1%        10.7%        12.9%       |18.8%        13.8%        10.2%        12.5%        |
|TERMINAL (d)       |     5/19 (26%)   2/11 (18%)   4/21 (19%)   2/24 (8%)   |5/29 (17%)   1/27 (4%)    4/23 (17%)   4/21 (19%)   |
|FIRST INCIDENCE    |     617          529          729 (T)      508         |533          652          730 (T)      610          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.183N     P=0.282      P=0.304N     P=0.381N    |P=0.369N     P=0.419N     P=0.288N     P=0.433N     |
|POLY 3             |     P=0.322N     P=0.483      P=0.367N     P=0.475N    |P=0.251N     P=0.369N     P=0.217N     P=0.313N     |
|POLY 1.5           |     P=0.339N     P=0.500      P=0.365N     P=0.488N    |P=0.231N     P=0.362N     P=0.194N     P=0.288N     |
|POLY 6             |     P=0.289N     P=0.458      P=0.360N     P=0.447N    |P=0.288N     P=0.380N     P=0.252N     P=0.358N     |
|LOGISTIC REGRESSION|     P=0.336N     P=0.459      P=0.321N     P=0.497N    |P=0.225N     P=0.356N     P=0.181N     P=0.263N     |
|COCH-ARM / FISHERS |     P=0.353N     P=0.517      P=0.356N     P=0.500N    |P=0.209N     P=0.354N     P=0.167N     P=0.262N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 10
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Colon                                                                                                           |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/47 (9%)    4/47 (9%)    4/47 (9%)    4/48 (8%)   |4/49 (8%)    5/50 (10%)   2/50 (4%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     10.5%        11.3%        10.7%        10.3%       |9.2%         11.6%        5.0%         7.4%         |
|TERMINAL (d)       |     3/19 (16%)   1/11 (9%)    3/21 (14%)   3/23 (13%)  |2/29 (7%)    5/27 (19%)   0/23 (0%)    2/21 (10%)   |
|FIRST INCIDENCE    |     558          617          701          534         |558          730 (T)      544          695          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.396N     P=0.457      P=0.598N     P=0.572N    |P=0.460N     P=0.467      P=0.411N     P=0.622N     |
|POLY 3             |     P=0.542N     P=0.607      P=0.638      P=0.631N    |P=0.357N     P=0.493      P=0.374N     P=0.537N     |
|POLY 1.5           |     P=0.551N     P=0.625      P=0.637      P=0.632N    |P=0.341N     P=0.504      P=0.357N     P=0.519N     |
|POLY 6             |     P=0.520N     P=0.578      P=0.646N     P=0.621N    |P=0.386N     P=0.474      P=0.395N     P=0.569N     |
|LOGISTIC REGRESSION|     P=0.529N     P=0.600      P=0.632N     P=0.632N    |P=0.340N     P=0.509      P=0.282N     P=0.504N     |
|COCH-ARM / FISHERS |     P=0.557N     P=0.643N     P=0.643N     P=0.631N    |P=0.321N     P=0.513      P=0.329N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Large, Rectum                                                                                                          |
|     Parasite Metazoan                                                                                                           |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/46 (2%)    2/47 (4%)    6/48 (13%)   3/47 (6%)   |1/44 (2%)    4/47 (9%)    3/48 (6%)    4/47 (9%)    |
|POLY-3 ADJUSTED (b)|     2.8%         5.7%         15.4%        7.9%        |2.6%         9.6%         7.8%         10.0%        |
|TERMINAL (d)       |     1/18 (6%)    1/11 (9%)    4/21 (19%)   3/23 (13%)  |1/26 (4%)    3/27 (11%)   1/22 (5%)    1/21 (5%)    |
|FIRST INCIDENCE    |     729 (T)      617          565          729 (T)     |730 (T)      638          589          462          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.373      P=0.387      P=0.082      P=0.394     |P=0.147      P=0.189      P=0.261      P=0.126      |
|POLY 3             |     P=0.240      P=0.493      P=0.067      P=0.324     |P=0.209      P=0.201      P=0.302      P=0.187      |
|POLY 1.5           |     P=0.226      P=0.501      P=0.064      P=0.318     |P=0.219      P=0.200      P=0.314      P=0.193      |
|POLY 6             |     P=0.273      P=0.479      P=0.075      P=0.338     |P=0.192      P=0.202      P=0.291      P=0.177      |
|LOGISTIC REGRESSION|     P=0.275      P=0.473      P=0.074      P=0.394     |P=0.229      P=0.199      P=0.326      P=0.212      |
|COCH-ARM / FISHERS |     P=0.216      P=0.508      P=0.062      P=0.317     |P=0.230      P=0.202      P=0.342      P=0.202      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 11
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    4/50 (8%)    1/50 (2%)   |2/50 (4%)    0/50 (0%)    0/49 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.3%         10.1%        2.5%        |4.6%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    1/21 (5%)    1/24 (4%)   |2/29 (7%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          529          617          729 (T)     |730 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.511      P=0.215      P=0.077      P=0.547     |P=0.146N     P=0.254N     P=0.290N     P=0.311N     |
|POLY 3             |     P=0.455      P=0.229      P=0.062      P=0.508     |P=0.116N     P=0.238N     P=0.262N     P=0.247N     |
|POLY 1.5           |     P=0.439      P=0.234      P=0.060      P=0.504     |P=0.116N     P=0.237N     P=0.254N     P=0.242N     |
|POLY 6             |     P=0.490      P=0.220      P=0.069      P=0.516     |P=0.115N     P=0.240N     P=0.270N     P=0.258N     |
|LOGISTIC REGRESSION|     P=0.424      P=0.242      P=0.062      P=0.547     |P=0.146N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.423      P=0.247      P=0.059      P=0.500     |P=0.116N     P=0.247N     P=0.253N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Infarct                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    1/50 (2%)    6/50 (12%)  |0/50 (0%)    1/50 (2%)    2/50 (4%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.6%         5.4%         2.5%         14.3%       |0.0%         2.3%         4.9%         7.1%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    1/24 (4%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     718          610          387          575         |---          729          390          533          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.037 *    P=0.441      P=0.752N     P=0.094     |P=0.056      P=0.493      P=0.228      P=0.113      |
|POLY 3             |     P=0.022 *    P=0.488      P=0.756N     P=0.069     |P=0.058      P=0.499      P=0.223      P=0.115      |
|POLY 1.5           |     P=0.020 *    P=0.494      P=0.760N     P=0.062     |P=0.060      P=0.500      P=0.228      P=0.117      |
|POLY 6             |     P=0.027 *    P=0.475      P=0.748N     P=0.083     |P=0.054      P=0.497      P=0.217      P=0.110      |
|LOGISTIC REGRESSION|     P=0.015 *    P=0.494      P=0.720N     P=0.056     |P=0.063      P=0.489      P=0.359      P=0.119      |
|COCH-ARM / FISHERS |     P=0.019 *    P=0.500      P=0.753N     P=0.056     |P=0.062      P=0.500      P=0.247      P=0.121      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 12
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          722          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.330N     P=0.168      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.405N     P=0.225      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.405N     P=0.232      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.405N     P=0.213      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.346N     P=0.170      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney                                                                                                                           |
|     Nephropathy                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     48/50 (96%)  50/50 (100%) 49/50 (98%)  50/50 (100%)|47/50 (94%)  48/50 (96%)  43/50 (86%)  46/50 (92%)  |
|POLY-3 ADJUSTED (b)|     97.8%        100.0%       99.5%        100.0%      |96.9%        98.1%        93.3%        95.2%        |
|TERMINAL (d)       |     19/19 (100%) 11/11 (100%) 21/21 (100%) 24/24 (100%)|29/29 (100%) 27/27 (100%) 22/23 (96%)  21/21 (100%) |
|FIRST INCIDENCE    |     354          465          340          444         |400          495          390          462          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.081N     P=0.060      P=0.434N     P=0.275N    |P=0.077      P=0.348      P=0.279      P=0.088      |
|POLY 3             |     P=0.258      P=0.462      P=0.589      P=0.462     |P=0.295N     P=0.654      P=0.330N     P=0.543N     |
|POLY 1.5           |     P=0.205      P=0.330      P=0.520      P=0.330     |P=0.293N     P=0.571      P=0.256N     P=0.514N     |
|POLY 6             |     P=0.479      P=0.780      P=0.817      P=0.780     |P=0.326N     P=0.833      P=0.422N     P=0.637N     |
|LOGISTIC REGRESSION|     P=0.178      P=0.236      P=0.411      P=0.253     |P=0.357N     P=0.614      P=0.387N     P=0.520N     |
|COCH-ARM / FISHERS |     P=0.188      P=0.247      P=0.500      P=0.247     |P=0.298N     P=0.500      P=0.159N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 13
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    1/50 (2%)    0/50 (0%)    1/50 (2%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.8%         2.7%         0.0%         2.5%        |2.3%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     3/19 (16%)   0/11 (0%)    0/21 (0%)    1/24 (4%)   |0/29 (0%)    1/27 (4%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     729 (T)      722          ---          729 (T)     |533          730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.126N     P=0.490N     P=0.101N     P=0.222N    |P=0.264N     P=0.755      P=0.517N     P=0.500N     |
|POLY 3             |     P=0.190N     P=0.322N     P=0.117N     P=0.290N    |P=0.245N     P=0.757      P=0.521N     P=0.512N     |
|POLY 1.5           |     P=0.196N     P=0.313N     P=0.120N     P=0.298N    |P=0.241N     P=0.759      P=0.513N     P=0.506N     |
|POLY 6             |     P=0.180N     P=0.341N     P=0.110N     P=0.274N    |P=0.251N     P=0.753      P=0.530N     P=0.522N     |
|LOGISTIC REGRESSION|     P=0.127N     P=0.445N     (e)          P=0.222N    |P=0.219N     P=0.746      P=0.385N     P=0.532N     |
|COCH-ARM / FISHERS |     P=0.200N     P=0.309N     P=0.121N     P=0.309N    |P=0.235N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         4.8%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     ---          633          ---          ---         |---          ---          ---          571          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.368N     P=0.202      (e)          (e)         |P=0.039 *    (e)          (e)          P=0.207      |
|POLY 3             |     P=0.403N     P=0.227      (e)          (e)         |P=0.043 *    (e)          (e)          P=0.230      |
|POLY 1.5           |     P=0.404N     P=0.233      (e)          (e)         |P=0.044 *    (e)          (e)          P=0.234      |
|POLY 6             |     P=0.401N     P=0.218      (e)          (e)         |P=0.042 *    (e)          (e)          P=0.221      |
|LOGISTIC REGRESSION|     P=0.401N     P=0.230      (e)          (e)         |P=0.046 *    (e)          (e)          P=0.244      |
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |P=0.046 *    (e)          (e)          P=0.247      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 14
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Larynx: Epiglottis                                                                                                               |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/49 (0%)    0/50 (0%)    0/49 (0%)   |1/50 (2%)    4/50 (8%)    2/50 (4%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |2.3%         9.3%         5.1%         2.4%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |1/29 (3%)    4/27 (15%)   1/23 (4%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |730 (T)      730 (T)      688          662          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.516N     P=0.156      P=0.433      P=0.725      |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.427N     P=0.177      P=0.470      P=0.752      |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.415N     P=0.179      P=0.481      P=0.757      |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.450N     P=0.172      P=0.458      P=0.743      |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.466N     P=0.156      P=0.449      P=0.756      |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.403N     P=0.181      P=0.500      P=0.753N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Angiectasis                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    1/50 (2%)   |2/50 (4%)    2/50 (4%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.6%         2.7%         5.2%         2.5%        |4.6%         4.6%         0.0%         2.4%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    2/21 (10%)   1/24 (4%)   |2/29 (7%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     729 (T)      652          729 (T)      729 (T)     |730 (T)      606          ---          705          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.519N     P=0.701      P=0.535      P=0.710N    |P=0.378N     P=0.676      P=0.290N     P=0.617N     |
|POLY 3             |     P=0.616      P=0.752      P=0.500      P=0.752N    |P=0.310N     P=0.691N     P=0.257N     P=0.515N     |
|POLY 1.5           |     P=0.603      P=0.756      P=0.497      P=0.756N    |P=0.304N     P=0.691N     P=0.250N     P=0.507N     |
|POLY 6             |     P=0.609N     P=0.742      P=0.512      P=0.743N    |P=0.320N     P=0.692N     P=0.267N     P=0.530N     |
|LOGISTIC REGRESSION|     P=0.576N     P=0.742      P=0.535      P=0.710N    |P=0.308N     P=0.695N     (e)          P=0.571N     |
|COCH-ARM / FISHERS |     P=0.591      P=0.753N     P=0.500      P=0.753N    |P=0.296N     P=0.691N     P=0.247N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 15
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     26/50 (52%)  21/50 (42%)  25/50 (50%)  27/50 (54%) |39/50 (78%)  41/50 (82%)  41/50 (82%)  38/50 (76%)  |
|POLY-3 ADJUSTED (b)|     62.6%        53.5%        61.5%        62.3%       |82.4%        86.5%        88.9%        82.4%        |
|TERMINAL (d)       |     14/19 (74%)  9/11 (82%)   18/21 (86%)  19/24 (79%) |25/29 (86%)  27/27 (100%) 23/23 (100%) 20/21 (95%)  |
|FIRST INCIDENCE    |     558          610          340          481         |508          495          247          472          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.135N     P=0.343      P=0.314N     P=0.282N    |P=0.072      P=0.285      P=0.070      P=0.109      |
|POLY 3             |     P=0.438      P=0.255N     P=0.553N     P=0.583N    |P=0.521N     P=0.389      P=0.255      P=0.612N     |
|POLY 1.5           |     P=0.379      P=0.227N     P=0.535N     P=0.558     |P=0.454N     P=0.402      P=0.320      P=0.553N     |
|POLY 6             |     P=0.544      P=0.330N     P=0.567N     P=0.532N    |P=0.492      P=0.360      P=0.169      P=0.541      |
|LOGISTIC REGRESSION|     P=0.520      P=0.357N     P=0.446N     P=0.559N    |P=0.477N     P=0.419      P=0.244      P=0.567N     |
|COCH-ARM / FISHERS |     P=0.325      P=0.212N     P=0.500N     P=0.500     |P=0.395N     P=0.402      P=0.402      P=0.500N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Clear Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     10/50 (20%)  7/50 (14%)   13/50 (26%)  9/50 (18%)  |12/50 (24%)  8/50 (16%)   5/50 (10%)   9/50 (18%)   |
|POLY-3 ADJUSTED (b)|     25.9%        19.0%        33.6%        22.4%       |27.8%        18.6%        12.4%        21.8%        |
|TERMINAL (d)       |     10/19 (53%)  6/11 (55%)   13/21 (62%)  9/24 (38%)  |11/29 (38%)  8/27 (30%)   4/23 (17%)   9/21 (43%)   |
|FIRST INCIDENCE    |     729 (T)      677          729 (T)      729 (T)     |710          730 (T)      462          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.145N     P=0.445      P=0.394      P=0.250N    |P=0.529      P=0.271N     P=0.125N     P=0.565      |
|POLY 3             |     P=0.518N     P=0.326N     P=0.307      P=0.459N    |P=0.317N     P=0.224N     P=0.068N     P=0.351N     |
|POLY 1.5           |     P=0.547      P=0.310N     P=0.303      P=0.480N    |P=0.301N     P=0.223N     P=0.063N     P=0.330N     |
|POLY 6             |     P=0.441N     P=0.361N     P=0.334      P=0.415N    |P=0.350N     P=0.231N     P=0.077N     P=0.398N     |
|LOGISTIC REGRESSION|     P=0.177N     P=0.607N     P=0.394      P=0.250N    |P=0.459N     P=0.255N     P=0.091N     P=0.567      |
|COCH-ARM / FISHERS |     P=0.512      P=0.298N     P=0.318      P=0.500N    |P=0.283N     P=0.227N     P=0.054N     P=0.312N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 16
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Degeneration Cystic                                                                                                         |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   6/50 (12%)   15/50 (30%)  6/50 (12%)  |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     17.9%        16.0%        38.0%        14.8%       |0.0%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     5/19 (26%)   1/11 (9%)    10/21 (48%)  4/24 (17%)  |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     617          579          644          654         |---          ---          ---          663          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.256N     P=0.459      P=0.075      P=0.341N    |P=0.197      (e)          (e)          P=0.495      |
|POLY 3             |     P=0.512N     P=0.536N     P=0.036 *    P=0.471N    |P=0.194      (e)          (e)          P=0.492      |
|POLY 1.5           |     P=0.547N     P=0.516N     P=0.037 *    P=0.486N    |P=0.196      (e)          (e)          P=0.496      |
|POLY 6             |     P=0.440N     P=0.573N     P=0.041 *    P=0.440N    |P=0.189      (e)          (e)          P=0.484      |
|LOGISTIC REGRESSION|     P=0.399N     P=0.613N     P=0.054      P=0.410N    |P=0.200      (e)          (e)          P=0.505      |
|COCH-ARM / FISHERS |     P=0.525      P=0.500N     P=0.045 *    P=0.500N    |P=0.198      (e)          (e)          P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Eosinophilic Focus                                                                                                          |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/50 (12%)   4/50 (8%)    3/50 (6%)    4/50 (8%)   |13/50 (26%)  10/50 (20%)  6/50 (12%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     15.2%        10.8%        7.7%         9.9%        |29.9%        23.1%        15.2%        12.0%        |
|TERMINAL (d)       |     3/19 (16%)   2/11 (18%)   0/21 (0%)    4/24 (17%)  |9/29 (31%)   9/27 (33%)   5/23 (22%)   4/21 (19%)   |
|FIRST INCIDENCE    |     617          674          673          729 (T)     |687          655          708          617          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.166N     P=0.601N     P=0.208N     P=0.251N    |P=0.079N     P=0.388N     P=0.168N     P=0.135N     |
|POLY 3             |     P=0.294N     P=0.407N     P=0.242N     P=0.354N    |P=0.020N*    P=0.317N     P=0.088N     P=0.036N*    |
|POLY 1.5           |     P=0.308N     P=0.387N     P=0.247N     P=0.362N    |P=0.019N*    P=0.314N     P=0.077N     P=0.034N*    |
|POLY 6             |     P=0.269N     P=0.445N     P=0.226N     P=0.338N    |P=0.025N*    P=0.329N     P=0.105N     P=0.044N*    |
|LOGISTIC REGRESSION|     P=0.237N     P=0.451N     P=0.233N     P=0.302N    |P=0.042N*    P=0.347N     P=0.126N     P=0.064N     |
|COCH-ARM / FISHERS |     P=0.319N     P=0.370N     P=0.243N     P=0.370N    |P=0.018N*    P=0.318N     P=0.062N     P=0.033N*    |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 17
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Fatty Change                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   10/50 (20%)  6/50 (12%)   3/50 (6%)   |11/50 (22%)  12/50 (24%)  12/50 (24%)  6/50 (12%)   |
|POLY-3 ADJUSTED (b)|     16.8%        25.2%        14.6%        7.2%        |23.7%        25.8%        27.6%        13.9%        |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |3/29 (10%)   3/27 (11%)   1/23 (4%)    0/21 (0%)    |
|FIRST INCIDENCE    |     521          533          387          444         |400          495          390          571          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.054N     P=0.245      P=0.490N     P=0.156N    |P=0.199N     P=0.479      P=0.370      P=0.221N     |
|POLY 3             |     P=0.058N     P=0.256      P=0.509N     P=0.151N    |P=0.145N     P=0.503      P=0.429      P=0.180N     |
|POLY 1.5           |     P=0.062N     P=0.276      P=0.510N     P=0.154N    |P=0.125N     P=0.503      P=0.452      P=0.163N     |
|POLY 6             |     P=0.050N     P=0.227      P=0.497N     P=0.144N    |P=0.179N     P=0.497      P=0.407      P=0.209N     |
|LOGISTIC REGRESSION|     P=0.072N     P=0.325      P=0.433N     P=0.162N    |P=0.062N     P=0.483      P=0.529N     P=0.107N     |
|COCH-ARM / FISHERS |     P=0.068N     P=0.298      P=0.500N     P=0.159N    |P=0.101N     P=0.500      P=0.500      P=0.143N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    0/50 (0%)    1/50 (2%)   |4/50 (8%)    5/50 (10%)   1/50 (2%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.2%         8.0%         0.0%         2.5%        |9.2%         11.6%        2.5%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |2/29 (7%)    4/27 (15%)   0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     708          617          ---          723         |708          667          583          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.175N     P=0.396      P=0.215N     P=0.418N    |P=0.040N*    P=0.454      P=0.256N     P=0.125N     |
|POLY 3             |     P=0.233N     P=0.485      P=0.237N     P=0.486N    |P=0.020N*    P=0.500      P=0.203N     P=0.066N     |
|POLY 1.5           |     P=0.238N     P=0.493      P=0.239N     P=0.493N    |P=0.019N*    P=0.501      P=0.194N     P=0.063N     |
|POLY 6             |     P=0.223N     P=0.469      P=0.229N     P=0.472N    |P=0.023N*    P=0.493      P=0.214N     P=0.073N     |
|LOGISTIC REGRESSION|     P=0.221N     P=0.470      P=0.215N     P=0.439N    |P=0.023N*    P=0.483      P=0.198N     P=0.087N     |
|COCH-ARM / FISHERS |     P=0.242N     P=0.500      P=0.247N     P=0.500N    |P=0.019N*    P=0.500      P=0.181N     P=0.059N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 18
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatodiaphragmatic Nodule                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    2/50 (4%)    0/50 (0%)    1/50 (2%)   |9/50 (18%)   6/50 (12%)   3/50 (6%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     2.6%         5.4%         0.0%         2.5%        |19.6%        13.6%        7.4%         2.4%         |
|TERMINAL (d)       |     1/19 (5%)    1/11 (9%)    0/21 (0%)    1/24 (4%)   |4/29 (14%)   2/27 (7%)    1/23 (4%)    1/21 (5%)    |
|FIRST INCIDENCE    |     729 (T)      723          ---          729 (T)     |400          544          583          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.379N     P=0.332      P=0.480N     P=0.710N    |P=0.011N*    P=0.324N     P=0.114N     P=0.022N*    |
|POLY 3             |     P=0.493N     P=0.482      P=0.500N     P=0.752N    |P=0.006N**   P=0.312N     P=0.092N     P=0.013N*    |
|POLY 1.5           |     P=0.497N     P=0.492      P=0.502N     P=0.756N    |P=0.005N**   P=0.301N     P=0.079N     P=0.010N*    |
|POLY 6             |     P=0.486N     P=0.464      P=0.493N     P=0.743N    |P=0.008N**   P=0.328N     P=0.108N     P=0.017N*    |
|LOGISTIC REGRESSION|     P=0.388N     P=0.367      (e)          P=0.710N    |P=0.003N**   P=0.304N     P=0.031N*    P=0.007N**   |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500      P=0.500N     P=0.753N    |P=0.004N**   P=0.288N     P=0.061N     P=0.008N**   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Mixed Cell Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    1/50 (2%)    1/50 (2%)   |6/50 (12%)   2/50 (4%)    4/50 (8%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     0.0%         2.7%         2.6%         2.5%        |13.8%        4.6%         10.0%        9.7%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    1/24 (4%)   |5/29 (17%)   1/27 (4%)    3/23 (13%)   4/21 (19%)   |
|FIRST INCIDENCE    |     ---          617          627          729 (T)     |617          722          544          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.434      P=0.500      P=0.500      P=0.547     |P=0.532      P=0.155N     P=0.502N     P=0.562N     |
|POLY 3             |     P=0.403      P=0.492      P=0.502      P=0.508     |P=0.461N     P=0.135N     P=0.423N     P=0.403N     |
|POLY 1.5           |     P=0.394      P=0.496      P=0.499      P=0.504     |P=0.447N     P=0.134N     P=0.403N     P=0.386N     |
|POLY 6             |     P=0.422      P=0.483      P=0.510      P=0.516     |P=0.486N     P=0.140N     P=0.447N     P=0.438N     |
|LOGISTIC REGRESSION|     P=0.384      P=0.505      P=0.507      P=0.547     |P=0.498N     P=0.138N     P=0.425N     P=0.474N     |
|COCH-ARM / FISHERS |     P=0.384      P=0.500      P=0.500      P=0.500     |P=0.430N     P=0.134N     P=0.370N     P=0.370N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 19
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   9/50 (18%)   4/50 (8%)    11/50 (22%) |3/50 (6%)    4/50 (8%)    3/50 (6%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     17.1%        23.0%        10.1%        25.8%       |6.9%         9.1%         7.4%         7.2%         |
|TERMINAL (d)       |     1/19 (5%)    1/11 (9%)    0/21 (0%)    2/24 (8%)   |1/29 (3%)    0/27 (0%)    0/23 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     354          579          627          575         |648          495          586          571          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.400      P=0.273      P=0.239N     P=0.334     |P=0.538      P=0.484      P=0.598      P=0.579      |
|POLY 3             |     P=0.245      P=0.347      P=0.279N     P=0.237     |P=0.550N     P=0.503      P=0.625      P=0.643      |
|POLY 1.5           |     P=0.230      P=0.367      P=0.278N     P=0.224     |P=0.535N     P=0.504      P=0.638      P=0.653      |
|POLY 6             |     P=0.283      P=0.318      P=0.268N     P=0.271     |P=0.574      P=0.497      P=0.611      P=0.621      |
|LOGISTIC REGRESSION|     P=0.218      P=0.412      P=0.248N     P=0.203     |P=0.501N     P=0.489      P=0.642N     P=0.656N     |
|COCH-ARM / FISHERS |     P=0.224      P=0.393      P=0.262N     P=0.218     |P=0.519N     P=0.500      P=0.661N     P=0.661N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Regeneration                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    0/50 (0%)    4/50 (8%)    0/50 (0%)   |1/50 (2%)    0/50 (0%)    0/50 (0%)    3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     2.6%         0.0%         10.0%        0.0%        |2.3%         0.0%         0.0%         7.2%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |1/29 (3%)    0/27 (0%)    0/23 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     648          ---          561          ---         |730 (T)      ---          ---          610          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.482N     P=0.513N     P=0.208      P=0.476N    |P=0.061      P=0.514N     P=0.546N     P=0.234      |
|POLY 3             |     P=0.499N     P=0.512N     P=0.185      P=0.493N    |P=0.080      P=0.501N     P=0.518N     P=0.292      |
|POLY 1.5           |     P=0.515N     P=0.506N     P=0.179      P=0.497N    |P=0.082      P=0.500N     P=0.511N     P=0.299      |
|POLY 6             |     P=0.466N     P=0.524N     P=0.200      P=0.487N    |P=0.077      P=0.503N     P=0.526N     P=0.278      |
|LOGISTIC REGRESSION|     P=0.539N     P=0.498N     P=0.183      P=0.504N    |P=0.079      (e)          (e)          P=0.288      |
|COCH-ARM / FISHERS |     P=0.531N     P=0.500N     P=0.181      P=0.500N    |P=0.086      P=0.500N     P=0.500N     P=0.309      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 20
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Bile Duct                                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     28/50 (56%)  29/50 (58%)  30/50 (60%)  36/50 (72%) |8/50 (16%)   8/50 (16%)   8/50 (16%)   5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     62.6%        63.2%        68.6%        77.2%       |18.2%        17.8%        19.0%        11.8%        |
|TERMINAL (d)       |     10/19 (53%)  4/11 (36%)   12/21 (57%)  17/24 (71%) |5/29 (17%)   4/27 (15%)   1/23 (4%)    1/21 (5%)    |
|FIRST INCIDENCE    |     529          465          484          481         |554          495          390          533          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.506      P=0.201      P=0.554N     P=0.381     |P=0.371N     P=0.570      P=0.463      P=0.430N     |
|POLY 3             |     P=0.050      P=0.564      P=0.351      P=0.087     |P=0.246N     P=0.593N     P=0.573      P=0.296N     |
|POLY 1.5           |     P=0.046 *    P=0.544      P=0.362      P=0.077     |P=0.232N     P=0.596N     P=0.584      P=0.285N     |
|POLY 6             |     P=0.066      P=0.576      P=0.376      P=0.113     |P=0.272N     P=0.597N     P=0.561      P=0.320N     |
|LOGISTIC REGRESSION|     P=0.056      P=0.522      P=0.396      P=0.079     |P=0.189N     P=0.603      P=0.558N     P=0.272N     |
|COCH-ARM / FISHERS |     P=0.050      P=0.500      P=0.420      P=0.072     |P=0.217N     P=0.607N     P=0.607N     P=0.277N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Centrilobular                                                                                                             |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/50 (8%)    9/50 (18%)   5/50 (10%)   4/50 (8%)   |2/50 (4%)    1/50 (2%)    1/50 (2%)    5/50 (10%)   |
|POLY-3 ADJUSTED (b)|     10.1%        23.0%        12.4%        9.5%        |4.5%         2.3%         2.5%         11.6%        |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    2/21 (10%)   0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     558          544          461          481         |508          561          666          541          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.253N     P=0.075      P=0.528      P=0.585N    |P=0.071      P=0.495N     P=0.536N     P=0.206      |
|POLY 3             |     P=0.302N     P=0.103      P=0.510      P=0.613N    |P=0.068      P=0.506N     P=0.539N     P=0.202      |
|POLY 1.5           |     P=0.326N     P=0.110      P=0.501      P=0.627N    |P=0.070      P=0.503N     P=0.524N     P=0.210      |
|POLY 6             |     P=0.263N     P=0.094      P=0.533      P=0.587N    |P=0.064      P=0.513N     P=0.555N     P=0.190      |
|LOGISTIC REGRESSION|     P=0.369N     P=0.118      P=0.513      P=0.623     |P=0.080      P=0.654N     P=0.371N     P=0.217      |
|COCH-ARM / FISHERS |     P=0.351N     P=0.117      P=0.500      P=0.643N    |P=0.075      P=0.500N     P=0.500N     P=0.218      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 21
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver: Kupffer Cell                                                                                                              |
|     Pigmentation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     23/50 (46%)  30/50 (60%)  34/50 (68%)  42/50 (84%) |15/50 (30%)  19/50 (38%)  36/50 (72%)  47/50 (94%)  |
|POLY-3 ADJUSTED (b)|     51.6%        67.8%        75.0%        90.1%       |32.8%        39.4%        77.7%        94.7%        |
|TERMINAL (d)       |     5/19 (26%)   5/11 (46%)   15/21 (71%)  23/24 (96%) |6/29 (21%)   4/27 (15%)   17/23 (74%)  20/21 (95%)  |
|FIRST INCIDENCE    |     558          479          340          481         |508          495          390          462          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.086      P=0.054      P=0.122      P=0.031 *   |P<0.001 **   P=0.266      P<0.001 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.080      P=0.013 *    P<0.001 **  |P<0.001 **   P=0.327      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.097      P=0.015 *    P<0.001 **  |P<0.001 **   P=0.303      P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.057      P=0.014 *    P<0.001 **  |P<0.001 **   P=0.352      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.113      P=0.021 *    P<0.001 **  |P<0.001 **   P=0.250      P<0.001 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.115      P=0.021 *    P<0.001 **  |P<0.001 **   P=0.263      P<0.001 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    2/50 (4%)    0/50 (0%)   |0/50 (0%)    2/50 (4%)    1/50 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         2.7%         5.2%         0.0%        |0.0%         4.6%         2.5%         0.0%         |
|TERMINAL (d)       |     1/19 (5%)    1/11 (9%)    1/21 (5%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/20 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      708          ---         |---          652          666          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.268N     P=0.636      P=0.538      P=0.453N    |P=0.504N     P=0.236      P=0.477      (e)          |
|POLY 3             |     P=0.346N     P=0.750      P=0.501      P=0.492N    |P=0.486N     P=0.238      P=0.483      (e)          |
|POLY 1.5           |     P=0.357N     P=0.756      P=0.498      P=0.496N    |P=0.476N     P=0.238      P=0.489      (e)          |
|POLY 6             |     P=0.326N     P=0.738      P=0.514      P=0.484N    |P=0.504N     P=0.237      P=0.477      (e)          |
|LOGISTIC REGRESSION|     P=0.283N     P=0.636      P=0.539      (e)         |P=0.463N     P=0.236      P=0.505      (e)          |
|COCH-ARM / FISHERS |     P=0.366N     P=0.753N     P=0.500      P=0.500N    |P=0.466N     P=0.247      P=0.500      (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 22
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    1/50 (2%)    3/50 (6%)    3/50 (6%)   |11/50 (22%)  11/50 (22%)  9/50 (18%)   13/49 (27%)  |
|POLY-3 ADJUSTED (b)|     0.0%         2.7%         7.5%         7.5%        |24.6%        25.0%        22.3%        31.5%        |
|TERMINAL (d)       |     0/19 (0%)    1/11 (9%)    1/21 (5%)    3/24 (13%)  |6/29 (21%)   6/27 (22%)   6/23 (26%)   7/20 (35%)   |
|FIRST INCIDENCE    |     ---          729 (T)      340          729 (T)     |533          610          583          663          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.128      P=0.391      P=0.132      P=0.163     |P=0.130      P=0.541      P=0.595      P=0.163      |
|POLY 3             |     P=0.077      P=0.490      P=0.124      P=0.125     |P=0.270      P=0.582      P=0.500N     P=0.317      |
|POLY 1.5           |     P=0.072      P=0.495      P=0.121      P=0.122     |P=0.303      P=0.589      P=0.463N     P=0.350      |
|POLY 6             |     P=0.088      P=0.479      P=0.132      P=0.132     |P=0.223      P=0.568      P=0.543N     P=0.266      |
|LOGISTIC REGRESSION|     P=0.067      P=0.391      P=0.147      P=0.163     |P=0.277      P=0.595N     P=0.460N     P=0.332      |
|COCH-ARM / FISHERS |     P=0.067      P=0.500      P=0.121      P=0.121     |P=0.343      P=0.595N     P=0.402N     P=0.385      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/20 (0%)    |
|FIRST INCIDENCE    |     ---          722          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.330N     P=0.168      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.405N     P=0.225      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.405N     P=0.232      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.405N     P=0.213      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.346N     P=0.170      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 23
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Alveolar Epithelium                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   13/50 (26%)  6/50 (12%)   14/50 (28%) |17/50 (34%)  7/50 (14%)   8/50 (16%)   5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     12.9%        32.9%        15.4%        32.5%       |38.5%        16.1%        19.5%        12.2%        |
|TERMINAL (d)       |     3/19 (16%)   6/11 (55%)   4/21 (19%)   8/24 (33%)  |11/29 (38%)  6/27 (22%)   4/23 (17%)   2/20 (10%)   |
|FIRST INCIDENCE    |     687          479          666          444         |638          584          496          662          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.206      P=0.005 **   P=0.580      P=0.059     |P=0.034N*    P=0.029N*    P=0.113N     P=0.033N*    |
|POLY 3             |     P=0.070      P=0.028 *    P=0.502      P=0.029 *   |P=0.006N**   P=0.015N*    P=0.042N*    P=0.004N**   |
|POLY 1.5           |     P=0.058      P=0.031 *    P=0.495      P=0.024 *   |P=0.006N**   P=0.015N*    P=0.037N*    P=0.004N**   |
|POLY 6             |     P=0.100      P=0.023 *    P=0.527      P=0.041 *   |P=0.007N**   P=0.016N*    P=0.049N*    P=0.006N**   |
|LOGISTIC REGRESSION|     P=0.062      P=0.025 *    P=0.559      P=0.023 *   |P=0.009N**   P=0.017N*    P=0.050N     P=0.008N**   |
|COCH-ARM / FISHERS |     P=0.050      P=0.033 *    P=0.500      P=0.020 *   |P=0.006N**   P=0.017N*    P=0.032N*    P=0.004N**   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Artery                                                                                                                     |
|     Infiltration Cellular Histiocyte                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         0.0%         0.0%         0.0%        |0.0%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/20 (0%)    |
|FIRST INCIDENCE    |     597          ---          ---          ---         |---          553          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.114N     P=0.259N     P=0.243N     P=0.234N    |P=0.572N     P=0.504      (e)          (e)          |
|POLY 3             |     P=0.108N     P=0.253N     P=0.241N     P=0.232N    |P=0.578N     P=0.502      (e)          (e)          |
|POLY 1.5           |     P=0.111N     P=0.245N     P=0.241N     P=0.235N    |P=0.574N     P=0.502      (e)          (e)          |
|POLY 6             |     P=0.103N     P=0.269N     P=0.237N     P=0.226N    |P=0.585N     P=0.501      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.114N     P=0.231N     P=0.224N     P=0.247N    |P=0.555N     P=0.408      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.115N     P=0.247N     P=0.247N     P=0.247N    |P=0.570N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 24
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung: Artery, Mediastinum                                                                                                        |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/20 (0%)    |
|FIRST INCIDENCE    |     ---          722          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.330N     P=0.168      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     P=0.405N     P=0.225      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     P=0.405N     P=0.232      (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     P=0.405N     P=0.213      (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.346N     P=0.170      (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Galactocele                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/44 (0%)    0/40 (0%)    1/44 (2%)    1/45 (2%)   |0/50 (0%)    2/50 (4%)    0/50 (0%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.9%         2.8%        |0.0%         4.6%         0.0%         0.0%         |
|TERMINAL (d)       |     0/15 (0%)    0/9 (0%)     0/18 (0%)    1/21 (5%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          716          729 (T)     |---          655          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.326      (e)          P=0.528      P=0.567     |P=0.440N     P=0.243      (e)          (e)          |
|POLY 3             |     P=0.270      (e)          P=0.508      P=0.515     |P=0.420N     P=0.238      (e)          (e)          |
|POLY 1.5           |     P=0.259      (e)          P=0.503      P=0.510     |P=0.414N     P=0.238      (e)          (e)          |
|POLY 6             |     P=0.294      (e)          P=0.518      P=0.526     |P=0.432N     P=0.236      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.320      (e)          P=0.533      P=0.567     |P=0.412N     P=0.238      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.247      (e)          P=0.500      P=0.506     |P=0.409N     P=0.247      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 25
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Mesentery: Fat                                                                                                                   |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/8 (100%)   6/6 (100%)   11/15 (73%)  8/8 (100%)  |12/12 (100%) 9/9 (100%)   6/8 (75%)    3/3 (100%)   |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       78.2%        100.0%      |100.0%       100.0%       77.7%        100.0%       |
|TERMINAL (d)       |     2/2 (100%)   1/1 (100%)   4/4 (100%)   5/5 (100%)  |9/9 (100%)   3/3 (100%)   3/3 (100%)   1/1 (100%)   |
|FIRST INCIDENCE    |     521          533          644          628         |617          495          544          612          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.147N     (e)          P=0.578      (e)         |P=0.348N     (e)          P=0.583      (e)          |
|POLY 3             |     P=0.596N     (e)          P=0.200N     (e)         |P=0.380N     (e)          P=0.160N     (e)          |
|POLY 1.5           |     P=0.581N     (e)          P=0.175N     (e)         |P=0.355N     (e)          P=0.146N     (e)          |
|POLY 6             |     P=0.614N     (e)          P=0.234N     (e)         |P=0.437N     (e)          P=0.194N     (e)          |
|LOGISTIC REGRESSION|     P=0.447N     (e)          P=0.120N     (e)         |P=0.328N     (e)          P=0.151N     (e)          |
|COCH-ARM / FISHERS |     P=0.554N     (e)          P=0.154N     (e)         |P=0.338N     (e)          P=0.147N     (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation                                                                                                                |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/48 (15%)   7/49 (14%)   10/49 (20%)  5/50 (10%)  |9/50 (18%)   8/48 (17%)   5/50 (10%)   4/49 (8%)    |
|POLY-3 ADJUSTED (b)|     17.6%        18.6%        25.0%        12.2%       |20.6%        19.0%        12.5%        9.8%         |
|TERMINAL (d)       |     1/19 (5%)    1/11 (9%)    4/21 (19%)   3/24 (13%)  |6/29 (21%)   5/27 (19%)   2/23 (9%)    3/21 (14%)   |
|FIRST INCIDENCE    |     529          575          370          495         |617          606          619          689          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.197N     P=0.431      P=0.355      P=0.299N    |P=0.181N     P=0.553N     P=0.336N     P=0.256N     |
|POLY 3             |     P=0.308N     P=0.570      P=0.294      P=0.355N    |P=0.085N     P=0.534N     P=0.242N     P=0.142N     |
|POLY 1.5           |     P=0.318N     P=0.599      P=0.297      P=0.354N    |P=0.077N     P=0.533N     P=0.224N     P=0.132N     |
|POLY 6             |     P=0.285N     P=0.521      P=0.305      P=0.349N    |P=0.100N     P=0.540N     P=0.265N     P=0.164N     |
|LOGISTIC REGRESSION|     P=0.325N     P=0.595N     P=0.324      P=0.355N    |P=0.097N     P=0.535N     P=0.256N     P=0.168N     |
|COCH-ARM / FISHERS |     P=0.325N     P=0.597N     P=0.314      P=0.351N    |P=0.069N     P=0.537N     P=0.194N     P=0.125N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 26
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    0/49 (0%)    0/50 (0%)   |3/50 (6%)    0/48 (0%)    1/50 (2%)    0/49 (0%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         0.0%         0.0%        |6.9%         0.0%         2.5%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |2/29 (7%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          ---          ---          ---         |533          ---          583          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |P=0.107N     P=0.130N     P=0.364N     P=0.162N     |
|POLY 3             |     (e)          (e)          (e)          (e)         |P=0.090N     P=0.127N     P=0.338N     P=0.133N     |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |P=0.088N     P=0.127N     P=0.326N     P=0.128N     |
|POLY 6             |     (e)          (e)          (e)          (e)         |P=0.092N     P=0.129N     P=0.352N     P=0.142N     |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |P=0.077N     P=0.132N     P=0.265N     P=0.119N     |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |P=0.087N     P=0.129N     P=0.309N     P=0.125N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose                                                                                                                             |
|     Thrombosis                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/48 (15%)   13/49 (27%)  11/49 (22%)  10/50 (20%) |2/50 (4%)    4/48 (8%)    6/50 (12%)   5/49 (10%)   |
|POLY-3 ADJUSTED (b)|     17.2%        32.5%        26.2%        23.2%       |4.5%         9.2%         14.6%        11.9%        |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    1/21 (5%)    1/24 (4%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     354          533          387          481         |508          495          586          571          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.521N     P=0.084      P=0.266      P=0.405     |P=0.153      P=0.341      P=0.104      P=0.208      |
|POLY 3             |     P=0.463      P=0.088      P=0.234      P=0.340     |P=0.158      P=0.329      P=0.108      P=0.194      |
|POLY 1.5           |     P=0.443      P=0.098      P=0.227      P=0.332     |P=0.168      P=0.326      P=0.116      P=0.201      |
|POLY 6             |     P=0.511      P=0.076      P=0.259      P=0.366     |P=0.142      P=0.331      P=0.101      P=0.183      |
|LOGISTIC REGRESSION|     P=0.408      P=0.141      P=0.307      P=0.316     |P=0.209      P=0.201      P=0.177      P=0.215      |
|COCH-ARM / FISHERS |     P=0.434      P=0.114      P=0.232      P=0.330     |P=0.181      P=0.319      P=0.134      P=0.210      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 27
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Degeneration Hyaline                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     13/48 (27%)  21/49 (43%)  23/49 (47%)  40/50 (80%) |13/50 (26%)  18/48 (38%)  28/50 (56%)  40/49 (82%)  |
|POLY-3 ADJUSTED (b)|     31.0%        50.9%        52.3%        81.1%       |28.3%        40.9%        60.4%        83.6%        |
|TERMINAL (d)       |     2/19 (11%)   5/11 (46%)   8/21 (38%)   17/24 (71%) |5/29 (17%)   9/27 (33%)   11/23 (48%)  17/21 (81%)  |
|FIRST INCIDENCE    |     529          536          370          444         |533          564          390          462          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P<0.001 **   P=0.035 *    P=0.079      P<0.001 **  |P<0.001 **   P=0.192      P=0.002 **   P<0.001 **   |
|POLY 3             |     P<0.001 **   P=0.045 *    P=0.032 *    P<0.001 **  |P<0.001 **   P=0.149      P<0.001 **   P<0.001 **   |
|POLY 1.5           |     P<0.001 **   P=0.058      P=0.031 *    P<0.001 **  |P<0.001 **   P=0.153      P<0.001 **   P<0.001 **   |
|POLY 6             |     P<0.001 **   P=0.032 *    P=0.038 *    P<0.001 **  |P<0.001 **   P=0.141      P<0.001 **   P<0.001 **   |
|LOGISTIC REGRESSION|     P<0.001 **   P=0.088      P=0.042 *    P<0.001 **  |P<0.001 **   P=0.153      P=0.004 **   P<0.001 **   |
|COCH-ARM / FISHERS |     P<0.001 **   P=0.078      P=0.034 *    P<0.001 **  |P<0.001 **   P=0.157      P=0.002 **   P<0.001 **   |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Olfactory Epithelium                                                                                                       |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/48 (8%)    5/49 (10%)   2/49 (4%)    3/50 (6%)   |3/50 (6%)    2/48 (4%)    0/50 (0%)    3/49 (6%)    |
|POLY-3 ADJUSTED (b)|     10.4%        13.5%        5.3%         7.3%        |6.9%         4.8%         0.0%         7.4%         |
|TERMINAL (d)       |     1/19 (5%)    1/11 (9%)    0/21 (0%)    1/24 (4%)   |2/29 (7%)    2/27 (7%)    0/23 (0%)    2/21 (10%)   |
|FIRST INCIDENCE    |     563          617          687          517         |617          730 (T)      ---          689          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.210N     P=0.349      P=0.305N     P=0.421N    |P=0.483      P=0.528N     P=0.159N     P=0.548      |
|POLY 3             |     P=0.286N     P=0.478      P=0.341N     P=0.465N    |P=0.572      P=0.521N     P=0.137N     P=0.631      |
|POLY 1.5           |     P=0.295N     P=0.495      P=0.340N     P=0.472N    |P=0.582      P=0.519N     P=0.130N     P=0.642      |
|POLY 6             |     P=0.267N     P=0.449      P=0.334N     P=0.450N    |P=0.556      P=0.526N     P=0.146N     P=0.609      |
|LOGISTIC REGRESSION|     P=0.292N     P=0.480      P=0.335N     P=0.477N    |P=0.548      P=0.517N     P=0.130N     P=0.627      |
|COCH-ARM / FISHERS |     P=0.301N     P=0.513      P=0.329N     P=0.477N    |P=0.593      P=0.520N     P=0.121N     P=0.651      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 28
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/48 (8%)    4/49 (8%)    6/49 (12%)   1/50 (2%)   |2/50 (4%)    0/48 (0%)    2/50 (4%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     10.5%        10.8%        15.5%        2.5%        |4.6%         0.0%         5.0%         2.5%         |
|TERMINAL (d)       |     2/19 (11%)   0/11 (0%)    3/21 (14%)   1/24 (4%)   |1/29 (3%)    0/27 (0%)    1/23 (4%)    1/21 (5%)    |
|FIRST INCIDENCE    |     708          575          584          729 (T)     |718          ---          619          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.091N     P=0.466      P=0.428      P=0.119N    |P=0.619      P=0.258N     P=0.618      P=0.621N     |
|POLY 3             |     P=0.139N     P=0.635      P=0.382      P=0.159N    |P=0.549N     P=0.245N     P=0.665      P=0.522N     |
|POLY 1.5           |     P=0.148N     P=0.643N     P=0.376      P=0.163N    |P=0.542N     P=0.245N     P=0.675      P=0.514N     |
|POLY 6             |     P=0.121N     P=0.615      P=0.405      P=0.150N    |P=0.562N     P=0.246N     P=0.653      P=0.538N     |
|LOGISTIC REGRESSION|     P=0.142N     P=0.608      P=0.374      P=0.122N    |P=0.560N     P=0.248N     P=0.665      P=0.596N     |
|COCH-ARM / FISHERS |     P=0.157N     P=0.631N     P=0.383      P=0.168N    |P=0.533N     P=0.258N     P=0.691N     P=0.508N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Nose: Respiratory Epithelium                                                                                                     |
|     Metaplasia                                                                                                                  |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/48 (0%)    0/49 (0%)    1/49 (2%)    0/50 (0%)   |1/50 (2%)    3/48 (6%)    0/50 (0%)    1/49 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.6%         0.0%        |2.3%         7.2%         0.0%         2.5%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    2/27 (7%)    0/23 (0%)    1/21 (5%)    |
|FIRST INCIDENCE    |     ---          ---          703          ---         |687          729          ---          730 (T)      |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.732      (e)          P=0.533      (e)         |P=0.506N     P=0.287      P=0.529N     P=0.704      |
|POLY 3             |     P=0.715      (e)          P=0.500      (e)         |P=0.431N     P=0.291      P=0.519N     P=0.746      |
|POLY 1.5           |     P=0.707      (e)          P=0.500      (e)         |P=0.421N     P=0.292      P=0.512N     P=0.751      |
|POLY 6             |     P=0.732      (e)          P=0.505      (e)         |P=0.447N     P=0.287      P=0.527N     P=0.735      |
|LOGISTIC REGRESSION|     P=0.711      (e)          P=0.505      (e)         |P=0.475N     P=0.288      P=0.509N     P=0.742      |
|COCH-ARM / FISHERS |     P=0.699      (e)          P=0.505      (e)         |P=0.411N     P=0.293      P=0.500N     P=0.747      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 29
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cyst                                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |                                                        |9/50 (18%)   7/50 (14%)   3/50 (6%)    4/50 (8%)    |
|POLY-3 ADJUSTED (b)|                                                        |20.7%        15.7%        7.6%         9.4%         |
|TERMINAL (d)       |                                                        |6/29 (21%)   2/27 (7%)    2/23 (9%)    0/21 (0%)    |
|FIRST INCIDENCE    |                                                        |648          495          649          533          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |                                                        |P=0.139N     P=0.443N     P=0.131N     P=0.234N     |
|POLY 3             |                                                        |P=0.069N     P=0.370N     P=0.080N     P=0.120N     |
|POLY 1.5           |                                                        |P=0.065N     P=0.378N     P=0.072N     P=0.117N     |
|POLY 6             |                                                        |P=0.076N     P=0.364N     P=0.091N     P=0.130N     |
|LOGISTIC REGRESSION|                                                        |P=0.063N     P=0.392N     P=0.094N     P=0.121N     |
|COCH-ARM / FISHERS |                                                        |P=0.062N     P=0.393N     P=0.061N     P=0.117N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     25/50 (50%)  25/50 (50%)  26/50 (52%)  22/50 (44%) |17/50 (34%)  15/50 (30%)  13/50 (26%)  13/50 (26%)  |
|POLY-3 ADJUSTED (b)|     56.6%        59.4%        59.0%        49.4%       |37.4%        32.8%        30.9%        30.5%        |
|TERMINAL (d)       |     10/19 (53%)  6/11 (55%)   9/21 (43%)   11/24 (46%) |11/29 (38%)  7/27 (26%)   7/23 (30%)   7/21 (33%)   |
|FIRST INCIDENCE    |     520          544          472          495         |508          495          462          617          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.080N     P=0.216      P=0.514N     P=0.188N    |P=0.501N     P=0.484N     P=0.480N     P=0.553N     |
|POLY 3             |     P=0.235N     P=0.479      P=0.494      P=0.317N    |P=0.285N     P=0.404N     P=0.337N     P=0.319N     |
|POLY 1.5           |     P=0.264N     P=0.528      P=0.481      P=0.328N    |P=0.252N     P=0.406N     P=0.307N     P=0.288N     |
|POLY 6             |     P=0.193N     P=0.407      P=0.544      P=0.298N    |P=0.341N     P=0.407N     P=0.374N     P=0.375N     |
|LOGISTIC REGRESSION|     P=0.273N     P=0.540      P=0.490      P=0.339N    |P=0.223N     P=0.417N     P=0.272N     P=0.280N     |
|COCH-ARM / FISHERS |     P=0.299N     P=0.579N     P=0.500      P=0.344N    |P=0.215N     P=0.415N     P=0.257N     P=0.257N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 30
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Basophilic Focus                                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    2/50 (4%)    5/50 (10%)   2/50 (4%)   |2/50 (4%)    5/50 (10%)   4/50 (8%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.8%         5.5%         12.5%        5.0%        |4.6%         11.6%        10.1%        0.0%         |
|TERMINAL (d)       |     3/19 (16%)   2/11 (18%)   3/21 (14%)   1/24 (4%)   |2/29 (7%)    5/27 (19%)   3/23 (13%)   0/21 (0%)    |
|FIRST INCIDENCE    |     729 (T)      729 (T)      370          723         |730 (T)      730 (T)      722          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.316N     P=0.630      P=0.404      P=0.390N    |P=0.238N     P=0.184      P=0.239      P=0.311N     |
|POLY 3             |     P=0.460N     P=0.524N     P=0.372      P=0.481N    |P=0.152N     P=0.214      P=0.296      P=0.247N     |
|POLY 1.5           |     P=0.481N     P=0.511N     P=0.361      P=0.491N    |P=0.142N     P=0.216      P=0.311      P=0.242N     |
|POLY 6             |     P=0.419N     P=0.549N     P=0.397      P=0.461N    |P=0.171N     P=0.208      P=0.279      P=0.258N     |
|LOGISTIC REGRESSION|     P=0.453N     P=0.630      P=0.354      P=0.389N    |P=0.237N     P=0.184      P=0.233      (e)          |
|COCH-ARM / FISHERS |     P=0.500N     P=0.500N     P=0.357      P=0.500N    |P=0.135N     P=0.218      P=0.339      P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pancreas                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/50 (6%)    5/50 (10%)   2/50 (4%)    2/50 (4%)   |1/50 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     7.8%         13.5%        5.2%         5.0%        |2.3%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     3/19 (16%)   3/11 (27%)   2/21 (10%)   1/24 (4%)   |0/29 (0%)    1/27 (4%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     729 (T)      677          729 (T)      723         |400          730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.136N     P=0.133      P=0.453N     P=0.390N    |P=0.262N     P=0.752      P=0.508N     P=0.500N     |
|POLY 3             |     P=0.251N     P=0.330      P=0.499N     P=0.481N    |P=0.245N     P=0.756      P=0.522N     P=0.513N     |
|POLY 1.5           |     P=0.263N     P=0.344      P=0.504N     P=0.491N    |P=0.242N     P=0.758      P=0.514N     P=0.507N     |
|POLY 6             |     P=0.228N     P=0.304      P=0.484N     P=0.461N    |P=0.251N     P=0.752      P=0.530N     P=0.523N     |
|LOGISTIC REGRESSION|     P=0.156N     P=0.212      P=0.453N     P=0.389N    |P=0.197N     P=0.700      P=0.230N     (e)          |
|COCH-ARM / FISHERS |     P=0.273N     P=0.357      P=0.500N     P=0.500N    |P=0.235N     P=0.753N     P=0.500N     P=0.500N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 31
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Parathyroid Gland                                                                                                                |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/47 (9%)    7/46 (15%)   2/47 (4%)    3/44 (7%)   |0/46 (0%)    0/48 (0%)    1/42 (2%)    0/43 (0%)    |
|POLY-3 ADJUSTED (b)|     11.0%        19.7%        5.6%         8.1%        |0.0%         0.0%         3.0%         0.0%         |
|TERMINAL (d)       |     1/16 (6%)    2/10 (20%)   2/19 (11%)   1/22 (5%)   |0/26 (0%)    0/26 (0%)    0/19 (0%)    0/17 (0%)    |
|FIRST INCIDENCE    |     564          536          729 (T)      519         |---          ---          666          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.135N     P=0.140      P=0.286N     P=0.424N    |P=0.681      (e)          P=0.477      (e)          |
|POLY 3             |     P=0.225N     P=0.240      P=0.341N     P=0.489N    |P=0.676      (e)          P=0.466      (e)          |
|POLY 1.5           |     P=0.246N     P=0.247      P=0.344N     P=0.511N    |P=0.681      (e)          P=0.471      (e)          |
|POLY 6             |     P=0.192N     P=0.225      P=0.328N     P=0.453N    |P=0.662      (e)          P=0.461      (e)          |
|LOGISTIC REGRESSION|     P=0.247N     P=0.238      P=0.320N     P=0.551N    |P=0.686      (e)          P=0.484      (e)          |
|COCH-ARM / FISHERS |     P=0.267N     P=0.249      P=0.339N     P=0.537N    |P=0.683      (e)          P=0.477      (e)          |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     16/49 (33%)  12/49 (24%)  16/48 (33%)  14/47 (30%) |15/50 (30%)  14/50 (28%)  11/49 (22%)  23/49 (47%)  |
|POLY-3 ADJUSTED (b)|     39.9%        31.7%        39.5%        35.9%       |31.7%        31.3%        25.9%        52.2%        |
|TERMINAL (d)       |     9/18 (50%)   3/11 (27%)   8/20 (40%)   9/23 (39%)  |6/29 (21%)   8/27 (30%)   4/23 (17%)   11/21 (52%)  |
|FIRST INCIDENCE    |     529          617          387          575         |400          495          462          533          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.168N     P=0.564      P=0.489N     P=0.214N    |P=0.012 *    P=0.553N     P=0.420N     P=0.029 *    |
|POLY 3             |     P=0.486N     P=0.297N     P=0.578N     P=0.445N    |P=0.020 *    P=0.573N     P=0.354N     P=0.035 *    |
|POLY 1.5           |     P=0.516N     P=0.273N     P=0.576      P=0.459N    |P=0.025 *    P=0.540N     P=0.318N     P=0.045 *    |
|POLY 6             |     P=0.422N     P=0.338N     P=0.525N     P=0.409N    |P=0.014 *    P=0.561      P=0.400N     P=0.023 *    |
|LOGISTIC REGRESSION|     P=0.474N     P=0.310N     P=0.561      P=0.411N    |P=0.039 *    P=0.510N     P=0.163N     P=0.070      |
|COCH-ARM / FISHERS |     P=0.540N     P=0.251N     P=0.557      P=0.467N    |P=0.035 *    P=0.500N     P=0.266N     P=0.063      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 32
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/46 (0%)    3/47 (6%)    0/50 (0%)    4/43 (9%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         8.6%         0.0%         11.8%       |                                                    |
|TERMINAL (d)       |     0/16 (0%)    1/11 (9%)    0/21 (0%)    2/19 (11%)  |                                                    |
|FIRST INCIDENCE    |     ---          702          ---          647         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.130      P=0.075      (e)          P=0.092     |                                                    |
|POLY 3             |     P=0.055      P=0.116      (e)          P=0.054     |                                                    |
|POLY 1.5           |     P=0.053      P=0.120      (e)          P=0.053     |                                                    |
|POLY 6             |     P=0.059      P=0.109      (e)          P=0.059     |                                                    |
|LOGISTIC REGRESSION|     P=0.077      P=0.090      (e)          P=0.063     |                                                    |
|COCH-ARM / FISHERS |     P=0.055      P=0.125      (e)          P=0.051     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Preputial Gland                                                                                                                  |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/46 (2%)    5/47 (11%)   2/50 (4%)    1/43 (2%)   |                                                    |
|POLY-3 ADJUSTED (b)|     2.9%         14.2%        5.1%         3.0%        |                                                    |
|TERMINAL (d)       |     1/16 (6%)    1/11 (9%)    1/21 (5%)    0/19 (0%)   |                                                    |
|FIRST INCIDENCE    |     729 (T)      664          542          718         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.239N     P=0.052      P=0.558      P=0.711N    |                                                    |
|POLY 3             |     P=0.348N     P=0.098      P=0.541      P=0.754     |                                                    |
|POLY 1.5           |     P=0.358N     P=0.103      P=0.532      P=0.749     |                                                    |
|POLY 6             |     P=0.326N     P=0.090      P=0.560      P=0.762N    |                                                    |
|LOGISTIC REGRESSION|     P=0.329N     P=0.071      P=0.530      P=0.736N    |                                                    |
|COCH-ARM / FISHERS |     P=0.367N     P=0.107      P=0.532      P=0.736     |                                                    |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 33
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     6/49 (12%)   9/49 (18%)   4/50 (8%)    8/50 (16%)  |                                                    |
|POLY-3 ADJUSTED (b)|     15.6%        24.4%        10.2%        19.8%       |                                                    |
|TERMINAL (d)       |     3/18 (17%)   6/11 (55%)   1/21 (5%)    7/24 (29%)  |                                                    |
|FIRST INCIDENCE    |     609          610          622          708         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.348N     P=0.093      P=0.310N     P=0.578     |                                                    |
|POLY 3             |     P=0.505      P=0.248      P=0.354N     P=0.420     |                                                    |
|POLY 1.5           |     P=0.490      P=0.269      P=0.361N     P=0.411     |                                                    |
|POLY 6             |     P=0.537      P=0.212      P=0.333N     P=0.440     |                                                    |
|LOGISTIC REGRESSION|     P=0.499N     P=0.209      P=0.347N     P=0.504     |                                                    |
|COCH-ARM / FISHERS |     P=0.477      P=0.288      P=0.357N     P=0.403     |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Prostate                                                                                                                         |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    3/49 (6%)    2/50 (4%)    1/50 (2%)   |                                                    |
|POLY-3 ADJUSTED (b)|     10.3%        8.1%         5.1%         2.5%        |                                                    |
|TERMINAL (d)       |     0/18 (0%)    0/11 (0%)    1/21 (5%)    0/24 (0%)   |                                                    |
|FIRST INCIDENCE    |     558          576          666          694         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.082N     P=0.558N     P=0.307N     P=0.155N    |                                                    |
|POLY 3             |     P=0.101N     P=0.529N     P=0.336N     P=0.166N    |                                                    |
|POLY 1.5           |     P=0.106N     P=0.514N     P=0.336N     P=0.170N    |                                                    |
|POLY 6             |     P=0.092N     P=0.557N     P=0.329N     P=0.159N    |                                                    |
|LOGISTIC REGRESSION|     P=0.109N     P=0.492N     P=0.327N     P=0.181N    |                                                    |
|COCH-ARM / FISHERS |     P=0.109N     P=0.500N     P=0.329N     P=0.175N    |                                                    |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 34
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Seminal Vesicle                                                                                                                  |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/47 (0%)    2/44 (5%)    0/46 (0%)    0/48 (0%)   |                                                    |
|POLY-3 ADJUSTED (b)|     0.0%         6.1%         0.0%         0.0%        |                                                    |
|TERMINAL (d)       |     0/18 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |                                                    |
|FIRST INCIDENCE    |     ---          722          ---          ---         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.330N     P=0.168      (e)          (e)         |                                                    |
|POLY 3             |     P=0.394N     P=0.214      (e)          (e)         |                                                    |
|POLY 1.5           |     P=0.395N     P=0.218      (e)          (e)         |                                                    |
|POLY 6             |     P=0.392N     P=0.205      (e)          (e)         |                                                    |
|LOGISTIC REGRESSION|     P=0.341N     P=0.175      (e)          (e)         |                                                    |
|COCH-ARM / FISHERS |     P=0.397N     P=0.231      (e)          (e)         |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Hyperkeratosis                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/50 (2%)    1/50 (2%)    3/50 (6%)    0/50 (0%)   |1/49 (2%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     2.6%         2.7%         7.7%         0.0%        |2.4%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    1/11 (9%)    2/21 (10%)   0/24 (0%)   |1/28 (4%)    1/27 (4%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     718          729 (T)      687          ---         |730 (T)      730 (T)      ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.296N     P=0.657      P=0.344      P=0.448N    |P=0.282N     P=0.754      P=0.539N     P=0.557N     |
|POLY 3             |     P=0.382N     P=0.750      P=0.306      P=0.492N    |P=0.240N     P=0.756N     P=0.513N     P=0.504N     |
|POLY 1.5           |     P=0.396N     P=0.755      P=0.302      P=0.496N    |P=0.237N     P=0.756N     P=0.507N     P=0.500N     |
|POLY 6             |     P=0.356N     P=0.738      P=0.318      P=0.484N    |P=0.245N     P=0.759N     P=0.521N     P=0.513N     |
|LOGISTIC REGRESSION|     P=0.328N     P=0.695      P=0.334      P=0.468N    |P=0.282N     P=0.754      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.409N     P=0.753N     P=0.309      P=0.500N    |P=0.233N     P=0.747N     P=0.495N     P=0.495N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 35
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    1/50 (2%)    4/50 (8%)    0/50 (0%)   |1/49 (2%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         2.7%         10.1%        0.0%        |2.4%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    1/21 (5%)    0/24 (0%)   |1/28 (4%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     597          617          370          ---         |730 (T)      ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.223N     P=0.536N     P=0.374      P=0.220N    |P=0.342N     P=0.507N     P=0.539N     P=0.557N     |
|POLY 3             |     P=0.255N     P=0.520N     P=0.342      P=0.231N    |P=0.305N     P=0.496N     P=0.513N     P=0.504N     |
|POLY 1.5           |     P=0.267N     P=0.509N     P=0.337      P=0.234N    |P=0.305N     P=0.495N     P=0.507N     P=0.500N     |
|POLY 6             |     P=0.233N     P=0.540N     P=0.355      P=0.225N    |P=0.302N     P=0.498N     P=0.521N     P=0.513N     |
|LOGISTIC REGRESSION|     P=0.287N     P=0.491N     P=0.349      P=0.243N    |P=0.342N     (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.279N     P=0.500N     P=0.339      P=0.247N    |P=0.303N     P=0.495N     P=0.495N     P=0.495N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Fibrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     11/50 (22%)  14/50 (28%)  19/50 (38%)  20/50 (40%) |2/50 (4%)    6/50 (12%)   7/50 (14%)   7/50 (14%)   |
|POLY-3 ADJUSTED (b)|     27.2%        35.7%        46.7%        46.9%       |4.6%         13.5%        17.0%        16.3%        |
|TERMINAL (d)       |     4/19 (21%)   4/11 (36%)   11/21 (52%)  12/24 (50%) |1/29 (3%)    1/27 (4%)    2/23 (9%)    1/21 (5%)    |
|FIRST INCIDENCE    |     558          575          584          508         |688          561          390          533          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.234      P=0.121      P=0.125      P=0.148     |P=0.058      P=0.133      P=0.056      P=0.056      |
|POLY 3             |     P=0.032 *    P=0.276      P=0.049 *    P=0.045 *   |P=0.088      P=0.140      P=0.066      P=0.075      |
|POLY 1.5           |     P=0.027 *    P=0.299      P=0.050      P=0.042 *   |P=0.092      P=0.138      P=0.071      P=0.078      |
|POLY 6             |     P=0.047 *    P=0.240      P=0.056      P=0.057     |P=0.079      P=0.141      P=0.062      P=0.070      |
|LOGISTIC REGRESSION|     P=0.042 *    P=0.258      P=0.061      P=0.051     |P=0.106      P=0.132      P=0.092      P=0.085      |
|COCH-ARM / FISHERS |     P=0.026 *    P=0.322      P=0.063      P=0.041 *   |P=0.097      P=0.134      P=0.080      P=0.080      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 36
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hematopoietic Cell Proliferation                                                                                            |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     8/50 (16%)   8/50 (16%)   6/50 (12%)   5/50 (10%)  |11/50 (22%)  17/50 (34%)  6/50 (12%)   4/50 (8%)    |
|POLY-3 ADJUSTED (b)|     20.0%        20.9%        14.7%        12.2%       |24.6%        38.7%        15.0%        9.6%         |
|TERMINAL (d)       |     2/19 (11%)   1/11 (9%)    2/21 (10%)   2/24 (8%)   |5/29 (17%)   13/27 (48%)  3/23 (13%)   2/21 (10%)   |
|FIRST INCIDENCE    |     609          617          387          589         |558          617          583          663          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.100N     P=0.398      P=0.346N     P=0.200N    |P=0.037N*    P=0.110      P=0.275N     P=0.130N     |
|POLY 3             |     P=0.162N     P=0.572      P=0.369N     P=0.254N    |P=0.008N**   P=0.111      P=0.201N     P=0.058N     |
|POLY 1.5           |     P=0.176N     P=0.591      P=0.381N     P=0.265N    |P=0.006N**   P=0.122      P=0.177N     P=0.050N     |
|POLY 6             |     P=0.139N     P=0.534      P=0.349N     P=0.236N    |P=0.013N*    P=0.095      P=0.234N     P=0.074N     |
|LOGISTIC REGRESSION|     P=0.186N     P=0.559      P=0.382N     P=0.256N    |P=0.010N*    P=0.127      P=0.175N     P=0.051N     |
|COCH-ARM / FISHERS |     P=0.191N     P=0.607N     P=0.387N     P=0.277N    |P=0.006N**   P=0.133      P=0.143N     P=0.045N*    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    3/50 (6%)    3/50 (6%)    3/50 (6%)   |0/50 (0%)    1/50 (2%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     5.1%         7.9%         7.6%         7.3%        |0.0%         2.3%         0.0%         0.0%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    1/21 (5%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     648          533          387          628         |---          701          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.536      P=0.459      P=0.540      P=0.558     |P=0.620N     P=0.488      (e)          (e)          |
|POLY 3             |     P=0.472      P=0.485      P=0.506      P=0.522     |P=0.576N     P=0.500      (e)          (e)          |
|POLY 1.5           |     P=0.454      P=0.493      P=0.501      P=0.511     |P=0.572N     P=0.500      (e)          (e)          |
|POLY 6             |     P=0.507      P=0.467      P=0.520      P=0.544     |P=0.582N     P=0.498      (e)          (e)          |
|LOGISTIC REGRESSION|     P=0.422      P=0.510      P=0.514      P=0.498     |P=0.576N     P=0.500      (e)          (e)          |
|COCH-ARM / FISHERS |     P=0.438      P=0.500      P=0.500      P=0.500     |P=0.567N     P=0.500      (e)          (e)          |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 37
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Pigmentation Hemosiderin                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     42/50 (84%)  45/50 (90%)  40/50 (80%)  44/50 (88%) |2/50 (4%)    0/50 (0%)    0/50 (0%)    0/50 (0%)    |
|POLY-3 ADJUSTED (b)|     88.1%        93.1%        87.1%        92.6%       |5.1%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     16/19 (84%)  11/11 (100%) 21/21 (100%) 23/24 (96%) |1/19 (5%)    0/11 (0%)    0/21 (0%)    0/24 (0%)    |
|FIRST INCIDENCE    |     354          465          340          444         |568          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.073N     P=0.053      P=0.285N     P=0.300N    |P=0.101N     P=0.296N     P=0.231N     P=0.209N     |
|POLY 3             |     P=0.361      P=0.290      P=0.578N     P=0.329     |P=0.109N     P=0.251N     P=0.239N     P=0.230N     |
|POLY 1.5           |     P=0.401      P=0.284      P=0.503N     P=0.351     |P=0.112N     P=0.244N     P=0.240N     P=0.234N     |
|POLY 6             |     P=0.322      P=0.298      P=0.651      P=0.314     |P=0.104N     P=0.265N     P=0.233N     P=0.223N     |
|LOGISTIC REGRESSION|     P=0.496      P=0.261      P=0.438N     P=0.415     |P=0.115N     P=0.235N     P=0.236N     P=0.241N     |
|COCH-ARM / FISHERS |     P=0.460      P=0.277      P=0.398N     P=0.387     |P=0.115N     P=0.247N     P=0.247N     P=0.247N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    2/50 (4%)    0/50 (0%)    0/50 (0%)   |0/50 (0%)    0/50 (0%)    0/50 (0%)    1/50 (2%)    |
|POLY-3 ADJUSTED (b)|     0.0%         5.4%         0.0%         0.0%        |0.0%         0.0%         0.0%         2.4%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     ---          722          ---          ---         |---          ---          ---          612          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.330N     P=0.168      (e)          (e)         |P=0.202      (e)          (e)          P=0.500      |
|POLY 3             |     P=0.405N     P=0.225      (e)          (e)         |P=0.194      (e)          (e)          P=0.493      |
|POLY 1.5           |     P=0.405N     P=0.232      (e)          (e)         |P=0.197      (e)          (e)          P=0.497      |
|POLY 6             |     P=0.405N     P=0.213      (e)          (e)         |P=0.190      (e)          (e)          P=0.485      |
|LOGISTIC REGRESSION|     P=0.346N     P=0.170      (e)          (e)         |P=0.198      (e)          (e)          P=0.502      |
|COCH-ARM / FISHERS |     P=0.405N     P=0.247      (e)          (e)         |P=0.198      (e)          (e)          P=0.500      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 38
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Ulcer                                                                                                                       |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     7/50 (14%)   9/50 (18%)   3/50 (6%)    3/50 (6%)   |2/50 (4%)    4/50 (8%)    7/50 (14%)   3/50 (6%)    |
|POLY-3 ADJUSTED (b)|     17.0%        22.3%        7.4%         7.2%        |4.5%         9.0%         16.5%        7.2%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    1/21 (5%)    0/24 (0%)   |0/29 (0%)    0/27 (0%)    1/23 (4%)    0/21 (0%)    |
|FIRST INCIDENCE    |     521          479          340          519         |575          553          462          652          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.046N*    P=0.337      P=0.165N     P=0.146N    |P=0.391      P=0.347      P=0.069      P=0.475      |
|POLY 3             |     P=0.049N*    P=0.369      P=0.164N     P=0.153N    |P=0.385      P=0.340      P=0.069      P=0.478      |
|POLY 1.5           |     P=0.051N     P=0.384      P=0.163N     P=0.156N    |P=0.407      P=0.340      P=0.072      P=0.489      |
|POLY 6             |     P=0.044N*    P=0.341      P=0.163N     P=0.147N    |P=0.348      P=0.338      P=0.066      P=0.459      |
|LOGISTIC REGRESSION|     P=0.055N     P=0.432      P=0.107N     P=0.172N    |P=0.479      P=0.289      P=0.142      P=0.516      |
|COCH-ARM / FISHERS |     P=0.054N     P=0.393      P=0.159N     P=0.159N    |P=0.430      P=0.339      P=0.080      P=0.500      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach: Epithelium                                                                                                 |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   8/50 (16%)   4/50 (8%)    4/50 (8%)   |3/50 (6%)    5/50 (10%)   6/50 (12%)   2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     12.6%        20.0%        10.0%        9.6%        |6.8%         11.1%        14.5%        4.8%         |
|TERMINAL (d)       |     2/19 (11%)   0/11 (0%)    1/21 (5%)    0/24 (0%)   |1/29 (3%)    0/27 (0%)    1/23 (4%)    0/21 (0%)    |
|FIRST INCIDENCE    |     609          533          472          444         |575          495          544          652          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.208N     P=0.209      P=0.469N     P=0.415N    |P=0.425N     P=0.363      P=0.193      P=0.544N     |
|POLY 3             |     P=0.243N     P=0.279      P=0.493N     P=0.465N    |P=0.408N     P=0.370      P=0.212      P=0.524N     |
|POLY 1.5           |     P=0.261N     P=0.280      P=0.500N     P=0.481N    |P=0.386N     P=0.366      P=0.222      P=0.512N     |
|POLY 6             |     P=0.212N     P=0.273      P=0.473N     P=0.436N    |P=0.446N     P=0.371      P=0.203      P=0.546N     |
|LOGISTIC REGRESSION|     P=0.299N     P=0.295      P=0.496N     P=0.516N    |P=0.318N     P=0.302      P=0.298      P=0.487N     |
|COCH-ARM / FISHERS |     P=0.279N     P=0.277      P=0.500N     P=0.500N    |P=0.362N     P=0.357      P=0.243      P=0.500N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 39
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Mineralization                                                                                                              |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     1/49 (2%)    3/49 (6%)    2/50 (4%)    4/50 (8%)   |3/50 (6%)    3/50 (6%)    2/49 (4%)    8/50 (16%)   |
|POLY-3 ADJUSTED (b)|     2.7%         8.3%         5.1%         9.8%        |7.0%         7.0%         5.1%         18.8%        |
|TERMINAL (d)       |     1/18 (6%)    1/11 (9%)    1/21 (5%)    2/24 (8%)   |3/29 (10%)   3/27 (11%)   2/23 (9%)    3/21 (14%)   |
|FIRST INCIDENCE    |     729 (T)      722          622          659         |730 (T)      730 (T)      730 (T)      612          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.312      P=0.174      P=0.539      P=0.266     |P=0.015 *    P=0.632      P=0.607N     P=0.055      |
|POLY 3             |     P=0.190      P=0.290      P=0.513      P=0.201     |P=0.034 *    P=0.661      P=0.541N     P=0.092      |
|POLY 1.5           |     P=0.179      P=0.298      P=0.507      P=0.193     |P=0.036 *    P=0.662N     P=0.528N     P=0.096      |
|POLY 6             |     P=0.214      P=0.274      P=0.529      P=0.219     |P=0.031 *    P=0.657      P=0.559N     P=0.085      |
|LOGISTIC REGRESSION|     P=0.228      P=0.197      P=0.517      P=0.220     |P=0.027 *    P=0.632      P=0.607N     P=0.088      |
|COCH-ARM / FISHERS |     P=0.169      P=0.309      P=0.508      P=0.187     |P=0.039 *    P=0.661N     P=0.510N     P=0.100      |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Glandular                                                                                                               |
|     Necrosis                                                                                                                    |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     4/49 (8%)    8/49 (16%)   4/50 (8%)    10/50 (20%) |2/50 (4%)    3/50 (6%)    4/49 (8%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     10.2%        20.7%        10.0%        23.0%       |4.5%         6.7%         9.9%         4.8%         |
|TERMINAL (d)       |     0/18 (0%)    0/11 (0%)    0/21 (0%)    1/24 (4%)   |0/29 (0%)    0/27 (0%)    0/23 (0%)    0/21 (0%)    |
|FIRST INCIDENCE    |     558          536          484          508         |508          495          586          638          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.174      P=0.145      P=0.624N     P=0.129     |P=0.563      P=0.508      P=0.287      P=0.673      |
|POLY 3             |     P=0.124      P=0.165      P=0.632N     P=0.104     |P=0.559      P=0.502      P=0.294      P=0.672      |
|POLY 1.5           |     P=0.108      P=0.172      P=0.636N     P=0.091     |P=0.579      P=0.502      P=0.308      P=0.682      |
|POLY 6             |     P=0.157      P=0.156      P=0.615N     P=0.131     |P=0.526      P=0.499      P=0.281      P=0.654      |
|LOGISTIC REGRESSION|     P=0.082      P=0.185      P=0.615N     P=0.066     |P=0.521N     P=0.364      P=0.407      P=0.698N     |
|COCH-ARM / FISHERS |     P=0.096      P=0.178      P=0.631N     P=0.080     |P=0.563N     P=0.500      P=0.329      P=0.691N     |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 40
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Atrophy                                                                                                                     |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     2/50 (4%)    2/50 (4%)    1/50 (2%)    2/50 (4%)   |                                                    |
|POLY-3 ADJUSTED (b)|     5.1%         5.3%         2.6%         5.0%        |                                                    |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    1/21 (5%)    2/24 (8%)   |                                                    |
|FIRST INCIDENCE    |     642          533          729 (T)      729 (T)     |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.475N     P=0.658      P=0.473N     P=0.630N    |                                                    |
|POLY 3             |     P=0.566N     P=0.681      P=0.504N     P=0.685N    |                                                    |
|POLY 1.5           |     P=0.572N     P=0.688      P=0.505N     P=0.689N    |                                                    |
|POLY 6             |     P=0.552N     P=0.665      P=0.497N     P=0.675N    |                                                    |
|LOGISTIC REGRESSION|     P=0.568N     P=0.686N     P=0.498N     P=0.674N    |                                                    |
|COCH-ARM / FISHERS |     P=0.577N     P=0.691N     P=0.500N     P=0.691N    |                                                    |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes: Interstitial Cell                                                                                                        |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     5/50 (10%)   2/50 (4%)    5/50 (10%)   8/50 (16%)  |                                                    |
|POLY-3 ADJUSTED (b)|     12.2%        5.3%         12.2%        18.3%       |                                                    |
|TERMINAL (d)       |     1/19 (5%)    0/11 (0%)    0/21 (0%)    2/24 (8%)   |                                                    |
|FIRST INCIDENCE    |     520          533          472          444         |                                                    |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.148      P=0.258N     P=0.622      P=0.325     |                                                    |
|POLY 3             |     P=0.131      P=0.246N     P=0.632N     P=0.317     |                                                    |
|POLY 1.5           |     P=0.116      P=0.231N     P=0.626      P=0.299     |                                                    |
|POLY 6             |     P=0.161      P=0.274N     P=0.614N     P=0.346     |                                                    |
|LOGISTIC REGRESSION|     P=0.074      P=0.194N     P=0.564N     P=0.232     |                                                    |
|COCH-ARM / FISHERS |     P=0.101      P=0.218N     P=0.630N     P=0.277     |                                                    |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 41
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     23/50 (46%)  31/46 (67%)  32/48 (67%)  17/48 (35%) |37/50 (74%)  41/48 (85%)  36/49 (73%)  29/50 (58%)  |
|POLY-3 ADJUSTED (b)|     53.1%        74.2%        75.1%        39.5%       |77.6%        87.5%        78.9%        63.6%        |
|TERMINAL (d)       |     10/19 (53%)  9/11 (82%)   16/21 (76%)  7/24 (29%)  |24/29 (83%)  25/27 (93%)  20/23 (87%)  15/21 (71%)  |
|FIRST INCIDENCE    |     354          479          472          444         |400          495          390          462          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.011N*    P=0.016 *    P=0.172      P=0.085N    |P=0.454N     P=0.199      P=0.205      P=0.542N     |
|POLY 3             |     P=0.026N*    P=0.026 *    P=0.020 *    P=0.138N    |P=0.018N*    P=0.149      P=0.542      P=0.090N     |
|POLY 1.5           |     P=0.040N*    P=0.025 *    P=0.021 *    P=0.163N    |P=0.014N*    P=0.136      P=0.568      P=0.079N     |
|POLY 6             |     P=0.013N*    P=0.031 *    P=0.026 *    P=0.105N    |P=0.029N*    P=0.177      P=0.522      P=0.115N     |
|LOGISTIC REGRESSION|     P=0.063N     P=0.026 *    P=0.029 *    P=0.204N    |P=0.014N*    P=0.128      P=0.562      P=0.078N     |
|COCH-ARM / FISHERS |     P=0.070N     P=0.028 *    P=0.031 *    P=0.195N    |P=0.012N*    P=0.125      P=0.567N     P=0.069N     |
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Hyperplasia                                                                                                                 |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     0/50 (0%)    0/46 (0%)    1/48 (2%)    1/48 (2%)   |0/50 (0%)    1/48 (2%)    1/49 (2%)    2/50 (4%)    |
|POLY-3 ADJUSTED (b)|     0.0%         0.0%         2.7%         2.6%        |0.0%         2.4%         2.5%         4.8%         |
|TERMINAL (d)       |     0/19 (0%)    0/11 (0%)    0/21 (0%)    1/24 (4%)   |0/29 (0%)    1/27 (4%)    1/23 (4%)    1/21 (5%)    |
|FIRST INCIDENCE    |     ---          ---          701          729 (T)     |---          730 (T)      730 (T)      694          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     P=0.307      (e)          P=0.532      P=0.547     |P=0.101      P=0.486      P=0.454      P=0.182      |
|POLY 3             |     P=0.251      (e)          P=0.495      P=0.501     |P=0.146      P=0.493      P=0.482      P=0.228      |
|POLY 1.5           |     P=0.243      (e)          P=0.492      P=0.496     |P=0.152      P=0.493      P=0.488      P=0.233      |
|POLY 6             |     P=0.269      (e)          P=0.503      P=0.510     |P=0.136      P=0.492      P=0.474      P=0.218      |
|LOGISTIC REGRESSION|     P=0.277      (e)          P=0.502      P=0.547     |P=0.118      P=0.486      P=0.454      P=0.212      |
|COCH-ARM / FISHERS |     P=0.234      (e)          P=0.490      P=0.490     |P=0.156      P=0.490      P=0.495      P=0.247      |
|=================================================================================================================================|
       Date:  02/23/98                           EXPERIMENT: 05197 TEST: 11                                            Page 42
                     Statistical Analysis of Non-neoplastic Lesions in       Rats(FISCHER 344)  -                  2-BUTOXYETHANOL
                                         Terminal Sacrifice at 104 weeks 
|=================================================================================================================================|
|                   |                                                        |                                                    |
|                   |                              Males                     |                       Females                      |
|Dose               |     CONTROL      31.2 PPM     62.5 PPM     125 PPM     |CONTROL      31.2 PPM     62.5 PPM     125 PPM      |
|                   |                                                        |                                                    |
|=================================================================================================================================|
|                                                                                                                                 |
|Tooth                                                                                                                            |
|     Inflammation Chronic                                                                                                        |
|                                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES        |                                                        |                                                    |
|-----------        |                                                        |                                                    |
|OVERALL (a)        |     3/3 (100%)   1/1 (100%)   0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|POLY-3 ADJUSTED (b)|     100.0%       100.0%       0.0%         0.0%        |0.0%         0.0%         0.0%         0.0%         |
|TERMINAL (d)       |     1/1 (100%)   0/0 (0%)     0/0 (0%)     0/0 (0%)    |0/0 (0%)     0/0 (0%)     0/0 (0%)     0/0 (0%)     |
|FIRST INCIDENCE    |     558          638          ---          ---         |---          ---          ---          ---          |
|-------------------|                                                        |                                                    |
|STATISTICAL TESTS  |                                                        |                                                    |
|-------------------|                                                        |                                                    |
|LIFE TABLE         |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 3             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 1.5           |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|POLY 6             |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|LOGISTIC REGRESSION|     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|COCH-ARM / FISHERS |     (e)          (e)          (e)          (e)         |(e)          (e)          (e)          (e)          |
|=================================================================================================================================|

(a)  Number of tumor-bearing animals /  number of animals examined at site.
(b)  Poly-3 adjusted lifetime tumor incidence.
(d)  Observed incidence at terminal kill.
(f)  Beneath the control incidence are the P-values associated with the trend 
test.  Beneath the dosed group incidence are the P-values corresponding to 
pairwise comparisons between the controls and that dosed group.  The life
table analysis regards tumors in animals dying prior to  terminal kill as
 being (directly or indirectly) the cause of death.
Logistic regression is an alternative
 method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e)  Value of Statistic cannot be computed.
(I)  Interim sacrifice
(T)  Terminal sacrifice
#   Tumor rates based on number of animals necropsied.
*   To the right of any statistical result, indicates significance at (P<=0.05).
**  To the right of any statistical result, indicates significance at (P<=0.01).