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TDMS Study 05197-12 Pathology Tables

NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10

                                                      FINAL#1, REVISION #1




       Facility:  Battelle Northwest

       Chemical CAS #:  111-76-0002

       Lock Date:  11/08/96

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Natural Death                                      6            3            5            4                                     
    Moribund Sacrifice                                14           16           12           10                                     
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                29           31           33           36                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (49)         (50)         (50)                                   
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Intestine Large, Colon                             (49)         (50)         (48)         (50)                                   
      Inflammation                                                               1 (2%)                                             
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Intestine Large, Cecum                             (49)         (50)         (47)         (48)                                   
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Intestine Small, Duodenum                          (45)         (49)         (47)         (47)                                   
      Inflammation                                                  2 (4%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Epithelium, Hyperplasia                          1 (2%)       2 (4%)                    2 (4%)                                
   Intestine Small, Jejunum                           (46)         (49)         (47)         (48)                                   
      Inflammation                                                                            1 (2%)                                
      Necrosis                                                                                1 (2%)                                
   Intestine Small, Ileum                             (46)         (50)         (47)         (48)                                   
      Peyer's Patch, Hyperplasia                                                              1 (2%)                                
   Liver                                              (50)         (50)         (49)         (50)                                   
      Angiectasis                                                   1 (2%)                    2 (4%)                                
      Basophilic Focus                                 1 (2%)                                 1 (2%)                                
      Clear Cell Focus                                 2 (4%)       1 (2%)                    1 (2%)                                
      Degeneration, Fatty                              2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Eosinophilic Focus                              10 (20%)      6 (12%)     10 (20%)      5 (10%)                               
      Hematopoietic Cell Proliferation                 5 (10%)      7 (14%)      1 (2%)       1 (2%)                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infarct                                                                    1 (2%)                                             
      Inflammation                                     3 (6%)       5 (10%)      4 (8%)       4 (8%)                                
      Necrosis                                         2 (4%)       8 (16%)      7 (14%)      3 (6%)                                
      Thrombosis                                                                 1 (2%)                                             
      Bile Duct, Cyst                                  1 (2%)                                                                       
      Endothelial Cell, Hyperplasia                                              1 (2%)                                             
      Kupffer Cell, Pigmentation, Hemosiderin                       5 (10%)     25 (51%)     44 (88%)                               
   Mesentery                                          (10)         (4)          (5)          (9)                                    
      Fat, Necrosis                                    7 (70%)      3 (75%)      4 (80%)      9 (100%)                              

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (49)         (50)         (49)         (50)                                   
      Atrophy                                          6 (12%)      4 (8%)       2 (4%)       8 (16%)                               
      Cytoplasmic Alteration                           1 (2%)       2 (4%)                    2 (4%)                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation                                                               3 (6%)                                             
      Duct, Cyst                                                    1 (2%)                    1 (2%)                                
      Duct, Inflammation                                            1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Erosion                                          1 (2%)                                                                       
      Ulcer                                            1 (2%)       7 (14%)     13 (27%)     22 (44%)                               
      Epithelium, Hyperplasia                          6 (12%)     27 (54%)     42 (86%)     44 (88%)                               
   Stomach, Glandular                                 (48)         (50)         (49)         (49)                                   
      Inflammation, Suppurative                                     1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Ulcer                                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Epithelium, Hyperplasia                          1 (2%)                    1 (2%)       1 (2%)                                
   Tongue                                             (1)                                    (1)                                    
      Epithelium, Hyperplasia                                                                 1 (100%)                              
   Tooth                                                           (1)                                                              
      Inflammation                                                  1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                       (2)                                    
      Inflammation                                                                            1 (50%)                               
      Mineralization                                                1 (100%)                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  46 (92%)     45 (90%)     44 (88%)     45 (90%)                               
      Mineralization                                                1 (2%)                                                          
      Artery, Inflammation                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Degeneration, Cystic                                                                    2 (4%)                                
      Hematopoietic Cell Proliferation                 1 (2%)       2 (4%)                                                          
      Hyperplasia                                      1 (2%)                                                                       
      Hypertrophy                                      3 (6%)       2 (4%)       6 (12%)      5 (10%)                               
      Capsule, Hyperplasia                                                       1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      1 (2%)       3 (6%)       3 (6%)       2 (4%)                                
   Islets, Pancreatic                                 (50)         (50)         (49)         (50)                                   
      Hyperplasia                                      1 (2%)                                                                       

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Pituitary Gland                                    (50)         (49)         (48)         (49)                                   
      Pars Distalis, Angiectasis                       1 (2%)       4 (8%)                                                          
      Pars Distalis, Hyperplasia                      15 (30%)     15 (31%)     16 (33%)     20 (41%)                               
      Pars Intermedia, Hyperplasia                     1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (49)                                   
      Inflammation                                                  1 (2%)                                                          
      Follicle, Cyst                                                                          1 (2%)                                
      Follicular Cell, Hyperplasia                    11 (22%)      8 (16%)     11 (22%)     11 (22%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (49)         (49)         (49)                                   
      Angiectasis                                      2 (4%)                    2 (4%)       1 (2%)                                
      Atrophy                                          1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Cyst                                            11 (22%)     12 (24%)     19 (39%)     16 (33%)                               
      Degeneration, Fatty                                                                     1 (2%)                                
      Infiltration Cellular, Mast Cell                                                        1 (2%)                                
      Inflammation                                     1 (2%)                    1 (2%)                                             
      Thrombosis                                       1 (2%)                    2 (4%)                                             
      Corpus Luteum, Hyperplasia                                                              1 (2%)                                
      Germinal Epithelium, Hyperplasia                              1 (2%)       1 (2%)                                             
      Interstitial Cell, Hyperplasia                                             1 (2%)                                             
   Uterus                                             (50)         (50)         (49)         (50)                                   
      Adenomyosis                                                                             1 (2%)                                
      Angiectasis                                      2 (4%)       3 (6%)       1 (2%)                                             
      Hydrometra                                       2 (4%)       2 (4%)       1 (2%)       3 (6%)                                
      Hyperplasia, Cystic                              2 (4%)                    2 (4%)       6 (12%)                               
      Inflammation                                     1 (2%)                                                                       
      Lymphangiectasis                                                           1 (2%)                                             
      Thrombosis                                       1 (2%)                                                                       
      Arteriole, Hyperplasia                                                                  1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Fibrosis                                                                                1 (2%)                                
      Hyperplasia                                      2 (4%)       4 (8%)       2 (4%)       3 (6%)                                
      Hyperplasia, Megakaryocyte                                                              1 (2%)                                
   Lymph Node                                         (4)          (7)          (6)          (1)                                    
      Angiectasis                                      1 (25%)      1 (14%)                                                         

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia                                      1 (25%)                                                                      
      Iliac, Hyperplasia                               1 (25%)                                                                      
      Pancreatic, Hyperplasia                                       1 (14%)                                                         
   Lymph Node, Bronchial                              (41)         (39)         (41)         (37)                                   
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       6 (15%)      4 (10%)                                            
      Hyperplasia, Histiocytic                                                                1 (3%)                                
   Lymph Node, Mandibular                             (37)         (38)         (40)         (38)                                   
      Hyperplasia                                      1 (3%)       2 (5%)       2 (5%)       1 (3%)                                
   Lymph Node, Mesenteric                             (47)         (48)         (49)         (50)                                   
      Hematopoietic Cell Proliferation                              1 (2%)       1 (2%)       1 (2%)                                
      Hyperplasia                                      1 (2%)       2 (4%)       3 (6%)       3 (6%)                                
   Lymph Node, Mediastinal                            (31)         (40)         (38)         (34)                                   
      Hyperplasia                                      2 (6%)       2 (5%)       5 (13%)                                            
      Hyperplasia, Lymphoid                                                      1 (3%)                                             
   Spleen                                             (50)         (50)         (49)         (50)                                   
      Hematopoietic Cell Proliferation                24 (48%)     29 (58%)     32 (65%)     35 (70%)                               
      Hyperplasia, Lymphoid                            6 (12%)     15 (30%)     12 (24%)     10 (20%)                               
      Pigmentation, Hemosiderin                       39 (78%)     44 (88%)     46 (94%)     48 (96%)                               
   Thymus                                             (46)         (41)         (46)         (48)                                   
      Atrophy                                          1 (2%)       2 (5%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       2 (5%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Hyperplasia                                      2 (4%)       2 (4%)       1 (2%)       2 (4%)                                
   Skin                                               (50)         (50)         (50)         (50)                                   
      Atrophy                                                       1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis                                                      1 (2%)                                                          
      Pinna, Inflammation, Chronic                     1 (2%)                                                                       
      Subcutaneous Tissue, Edema                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Arthrosis                                                                               1 (2%)                                
      Fibrous Osteodystrophy                          22 (44%)     28 (56%)     25 (50%)     21 (42%)                               
      Maxilla, Fracture                                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Hemorrhage                                       1 (2%)                    1 (2%)       1 (2%)                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Necrosis                                         1 (2%)                                                                       
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         2 (4%)                                 2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)         (49)                                   
      Inflammation, Suppurative                        1 (2%)       3 (6%)                    1 (2%)                                
      Squamous Epithelium, Hyperplasia                 2 (4%)       8 (16%)      3 (6%)       5 (10%)                               
   Lung                                               (50)         (50)         (50)         (50)                                   
      Hemorrhage                                      10 (20%)      2 (4%)       6 (12%)      6 (12%)                               
      Infiltration Cellular, Histiocyte                3 (6%)       2 (4%)       3 (6%)       2 (4%)                                
      Inflammation                                                  1 (2%)                                                          
      Metaplasia, Osseous                              1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 2 (4%)       2 (4%)                    2 (4%)                                
      Mediastinum, Inflammation                                     1 (2%)                                                          
      Perivascular, Inflammation                       2 (4%)                                                                       
   Nose                                               (50)         (50)         (49)         (50)                                   
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Inflammation, Suppurative                        2 (4%)       3 (6%)       1 (2%)                                             
      Olfactory Epithelium, Atrophy                    2 (4%)       4 (8%)       2 (4%)       4 (8%)                                
      Olfactory Epithelium, Degeneration, Hyaline      6 (12%)     14 (28%)     11 (22%)     12 (24%)                               
      Olfactory Epithelium, Metaplasia                 1 (2%)       1 (2%)                                                          
      Respiratory Epithelium, Degeneration, Hyaline   17 (34%)     35 (70%)     26 (53%)     23 (46%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (1)                                    (4)                                    
      Degeneration                                                                            1 (25%)                               
      Cornea, Inflammation, Chronic                    1 (100%)                               3 (75%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)                                   
      Glomerulosclerosis                               7 (14%)      2 (4%)       8 (16%)      8 (16%)                               
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Metaplasia, Osseous                              1 (2%)       1 (2%)       3 (6%)       4 (8%)                                
      Nephropathy                                     34 (68%)     39 (78%)     38 (78%)     33 (66%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE FEMALE                        CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Pigmentation, Hemosiderin                        1 (2%)       1 (2%)                                                          
      Renal Tubule, Degeneration                                                 1 (2%)                                             
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Renal Tubule, Mineralization                                  1 (2%)                                                          
   Urinary Bladder                                    (47)         (49)         (48)         (50)                                   
      Inflammation                                     1 (2%)       1 (2%)                                                          
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 


  Animals Initially In Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 7            8           13           10                                     
    Natural Death                                      4            3           10           14                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                39           39           27           26                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (42)         (45)         (40)         (35)                                   
      Degeneration, Hyaline                                         1 (2%)                                                          
      Inflammation                                                  1 (2%)                                                          
   Intestine Small, Duodenum                          (49)         (48)         (44)         (41)                                   
      Inflammation                                                                            1 (2%)                                
      Epithelium, Hyperplasia                                                                 1 (2%)                                
      Peyer's Patch, Hyperplasia                       1 (2%)                                                                       
   Intestine Small, Jejunum                           (48)         (47)         (43)         (38)                                   
      Peyer's Patch, Hyperplasia                       1 (2%)                                 1 (3%)                                
   Intestine Small, Ileum                             (48)         (47)         (43)         (39)                                   
      Inflammation                                     1 (2%)                                                                       
      Peyer's Patch, Hyperplasia                       1 (2%)       1 (2%)                                                          
   Liver                                              (50)         (50)         (49)         (49)                                   
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                                           1 (2%)       3 (6%)                                
      Clear Cell Focus                                 4 (8%)                    5 (10%)      3 (6%)                                
      Degeneration, Fatty                              1 (2%)       2 (4%)       4 (8%)                                             
      Eosinophilic Focus                              14 (28%)     10 (20%)     18 (37%)     12 (24%)                               
      Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)       2 (4%)       2 (4%)                                
      Hepatodiaphragmatic Nodule                                                 1 (2%)                                             
      Infarct                                                       1 (2%)                                                          
      Inflammation                                     6 (12%)      3 (6%)       6 (12%)      6 (12%)                               
      Karyomegaly                                      2 (4%)                                 1 (2%)                                
      Necrosis                                         6 (12%)      2 (4%)       7 (14%)      9 (18%)                               
      Bile Duct, Cyst                                                            1 (2%)       1 (2%)                                
      Kupffer Cell, Pigmentation, Hemosiderin                                    8 (16%)     30 (61%)                               
      Oval Cell, Hyperplasia                           1 (2%)       1 (2%)       2 (4%)       3 (6%)                                
   Mesentery                                          (5)          (3)          (3)          (1)                                    
      Angiectasis                                                   1 (33%)                                                         
      Fat, Necrosis                                    5 (100%)     2 (67%)      2 (67%)                                            
   Pancreas                                           (50)         (50)         (47)         (47)                                   
      Atrophy                                         10 (20%)      4 (8%)       2 (4%)       4 (9%)                                
      Cytoplasmic Alteration                           1 (2%)                                 1 (2%)                                
      Degeneration, Hyaline                                         1 (2%)                                                          

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Inflammation                                                  1 (2%)                                                          
      Duct, Cyst                                                    1 (2%)                                                          
   Salivary Glands                                    (50)         (50)         (48)         (50)                                   
      Inflammation                                                  1 (2%)       1 (2%)       1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (49)         (48)                                   
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Mineralization                                                                          1 (2%)                                
      Ulcer                                            1 (2%)       2 (4%)       9 (18%)      3 (6%)                                
      Epithelium, Hyperplasia                          1 (2%)       7 (14%)     16 (33%)     21 (44%)                               
   Stomach, Glandular                                 (50)         (50)         (46)         (47)                                   
      Degeneration, Hyaline                                                      1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mineralization                                   1 (2%)       1 (2%)       1 (2%)       2 (4%)                                
      Ulcer                                                         1 (2%)       2 (4%)                                             
      Epithelium, Hyperplasia                                                    4 (9%)       1 (2%)                                
   Tooth                                                           (4)                                                              
      Malformation                                                  4 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Cardiomyopathy                                  47 (94%)     48 (96%)     47 (94%)     47 (94%)                               
      Artery, Inflammation                             1 (2%)                                                                       
      Atrium, Thrombosis                               1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (49)         (50)                                   
      Degeneration, Cystic                             1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                    1 (2%)                                             
      Hyperplasia                                      5 (10%)      9 (18%)      9 (18%)      9 (18%)                               
      Hypertrophy                                     38 (76%)     28 (56%)     27 (55%)     27 (54%)                               
      Capsule, Hyperplasia                             2 (4%)                                 3 (6%)                                
   Adrenal Medulla                                    (49)         (50)         (49)         (49)                                   
      Hyperplasia                                      1 (2%)       2 (4%)                    3 (6%)                                
   Islets, Pancreatic                                 (50)         (50)         (47)         (46)                                   
      Hyperplasia                                      6 (12%)      3 (6%)       2 (4%)                                             
      Inflammation                                     1 (2%)                                                                       
   Parathyroid Gland                                  (26)         (29)         (26)         (31)                                   
      Cyst                                                          1 (3%)                                                          
   Pituitary Gland                                    (49)         (49)         (46)         (48)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Pars Distalis, Cyst                              1 (2%)                                                                       
      Pars Distalis, Hyperplasia                       5 (10%)      1 (2%)       2 (4%)       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (50)         (48)         (49)         (50)                                   
      Follicular Cell, Hyperplasia                     5 (10%)      8 (17%)      6 (12%)      5 (10%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (49)         (50)                                   
      Granuloma Sperm                                               1 (2%)                                                          
      Hyperplasia                                                                             1 (2%)                                
      Inflammation                                     4 (8%)       4 (8%)       1 (2%)       4 (8%)                                
      Inflammation, Granulomatous                                                1 (2%)                                             
   Penis                                                                        (1)                                                 
      Inflammation                                                               1 (100%)                                           
   Preputial Gland                                    (49)         (49)         (49)         (49)                                   
      Ectasia                                          1 (2%)       1 (2%)                    1 (2%)                                
      Inflammation                                     2 (4%)       7 (14%)      6 (12%)      8 (16%)                               
   Prostate                                           (49)         (49)         (48)         (45)                                   
      Inflammation                                                  2 (4%)       3 (6%)       4 (9%)                                
      Epithelium, Hyperplasia                                                    1 (2%)       1 (2%)                                
   Seminal Vesicle                                    (50)         (49)         (46)         (46)                                   
      Inflammation                                     1 (2%)                    2 (4%)       3 (7%)                                
   Testes                                             (50)         (50)         (49)         (50)                                   
      Atrophy                                          5 (10%)      4 (8%)       6 (12%)      4 (8%)                                
      Mineralization                                                             3 (6%)                                             
      Interstitial Cell, Hyperplasia                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)                                   
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                                   1 (2%)       9 (18%)      5 (10%)                               
      Thrombosis                                                                              1 (2%)                                
   Lymph Node                                         (2)          (1)                       (1)                                    
      Renal, Hyperplasia                                                                      1 (100%)                              
   Lymph Node, Bronchial                              (38)         (35)         (33)         (35)                                   
      Hyperplasia                                      2 (5%)                    1 (3%)                                             
   Lymph Node, Mandibular                             (24)         (26)         (32)         (25)                                   
      Hyperplasia                                                   1 (4%)       1 (3%)       1 (4%)                                
   Lymph Node, Mesenteric                             (50)         (50)         (47)         (43)                                   
      Amyloid Deposition                               1 (2%)                                                                       
      Angiectasis                                      2 (4%)       2 (4%)                    1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hematopoietic Cell Proliferation                 1 (2%)       3 (6%)       1 (2%)                                             
      Hyperplasia                                      7 (14%)      7 (14%)      4 (9%)       4 (9%)                                
   Spleen                                             (50)         (50)         (48)         (49)                                   
      Hematopoietic Cell Proliferation                12 (24%)     11 (22%)     26 (54%)     42 (86%)                               
      Hyperplasia, Lymphoid                            5 (10%)      8 (16%)      3 (6%)       1 (2%)                                
      Pigmentation, Hemosiderin                                     6 (12%)     45 (94%)     44 (90%)                               
   Thymus                                             (43)         (43)         (36)         (37)                                   
      Atrophy                                          1 (2%)       1 (2%)       1 (3%)       1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (49)         (50)                                   
      Granuloma                                                                  1 (2%)                                             
      Inflammation                                                  1 (2%)                                                          
      Pigmentation, Melanin                                                      1 (2%)                                             
      Prepuce, Hyperplasia                                                       1 (2%)       2 (4%)                                
      Prepuce, Inflammation, Chronic Active            2 (4%)       3 (6%)      13 (27%)      8 (16%)                               
      Prepuce, Ulcer                                                3 (6%)      11 (22%)      8 (16%)                               
      Subcutaneous Tissue, Inflammation,                                                                                            
          Granulomatous                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Fibrous Osteodystrophy                           1 (2%)       4 (8%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Inflammation, Chronic                            1 (2%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      Vacuolization Cytoplasmic                                                  1 (2%)       1 (2%)                                
      Meninges, Infiltration Cellular, Mononuclear                                                                                  
          Cell                                         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (48)         (49)                                   
      Inflammation, Suppurative                                                               1 (2%)                                
      Squamous Epithelium, Hyperplasia                              3 (6%)                                                          
   Lung                                               (50)         (50)         (49)         (50)                                   
      Hematopoietic Cell Proliferation                                           1 (2%)       1 (2%)                                
      Hemorrhage                                       5 (10%)      5 (10%)      5 (10%)      3 (6%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Infiltration Cellular, Histiocyte                6 (12%)      1 (2%)       4 (8%)       4 (8%)                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Pigmentation, Hemosiderin                        1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 6 (12%)      1 (2%)       2 (4%)       4 (8%)                                
      Artery, Inflammation                                                                    1 (2%)                                
   Nose                                               (50)         (50)         (48)         (48)                                   
      Inflammation, Suppurative                        2 (4%)       6 (12%)      2 (4%)       2 (4%)                                
      Polyp, Inflammatory                                           1 (2%)       1 (2%)                                             
      Glands, Hyperplasia                                                                     1 (2%)                                
      Olfactory Epithelium, Atrophy                    4 (8%)       4 (8%)       3 (6%)                                             
      Olfactory Epithelium, Degeneration, Hyaline      1 (2%)       2 (4%)       3 (6%)       1 (2%)                                
      Respiratory Epithelium, Degeneration, Hyaline    4 (8%)      10 (20%)      5 (10%)      5 (10%)                               
      Respiratory Epithelium, Metaplasia, Squamous                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Inflammation, Granulomatous                      1 (100%)                                                                     
   Eye                                                (1)                       (1)                                                 
      Cornea, Inflammation, Chronic                                              1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (47)         (50)                                   
      Glomerulosclerosis                               4 (8%)       4 (8%)      11 (23%)      9 (18%)                               
      Hydronephrosis                                   1 (2%)                    6 (13%)      5 (10%)                               
      Inflammation                                                                            1 (2%)                                
      Inflammation, Chronic Active                                  1 (2%)       2 (4%)       4 (8%)                                
      Metaplasia, Osseous                                           2 (4%)                                                          
      Mineralization                                   1 (2%)                                 2 (4%)                                
      Nephropathy                                     48 (96%)     45 (90%)     40 (85%)     37 (74%)                               
      Capsule, Inflammation                                                                   1 (2%)                                
      Cortex, Cyst                                     4 (8%)       1 (2%)                    6 (12%)                               
      Pelvis, Inflammation, Chronic Active                          1 (2%)       1 (2%)                                             
      Renal Tubule, Hyperplasia                        2 (4%)       2 (4%)       1 (2%)                                             
      Renal Tubule, Mineralization                     4 (8%)       2 (4%)       3 (6%)       2 (4%)                                
      Renal Tubule, Necrosis                           1 (2%)                    1 (2%)                                             
      Renal Tubule, Pigmentation                                                              3 (6%)                                
   Urinary Bladder                                    (50)         (50)         (46)         (45)                                   
      Inflammation                                                  2 (4%)       5 (11%)      4 (9%)                                
      Transitional Epithelium, Hyperplasia                          2 (4%)       1 (2%)       1 (2%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             
NTP Experiment-Test: 05197-12         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          2-BUTOXYETHANOL                                      Date: 08/23/99  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 11:23:10  
____________________________________________________________________________________________________________________________________

         B6C3F1 MICE MALE                          CONTROL      62.5 PPM     125 PPM      250 PPM                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Ulcer                                1 (2%)       4 (9%)       2 (4%)                                
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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