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TDMS Study 05201-05 Pathology Tables

NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30

                                                    2 YEAR CHRONIC FINAL #2




       Facility:  Battelle Northwest

       Chemical CAS #:  0098-00-0000

       Lock Date:  01/26/95

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All


































a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23           21           24           32                                     
    Natural Death                                      1            3            3            2                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                26           25           22           16                                     
    Natural Death                                                   1                                                               
  Other                                                                          1                                                  

  Animals Examined Microscopically                    50           50           49           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (47)         (48)         (48)                                   
   Intestine Large, Rectum                            (50)         (47)         (47)         (49)                                   
      Fibroma                                                                    1 (2%)                                             
      Leiomyosarcoma                                                             1 (2%)                                             
   Intestine Large, Cecum                             (49)         (47)         (46)         (48)                                   
   Intestine Small, Duodenum                          (50)         (49)         (47)         (49)                                   
   Intestine Small, Jejunum                           (49)         (47)         (47)         (48)                                   
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Ileum                             (49)         (47)         (46)         (48)                                   
   Liver                                              (50)         (49)         (49)         (50)                                   
      Hepatocellular Adenoma                           1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             2 (4%)                                             
   Mesentery                                          (15)         (8)          (11)         (7)                                    
      Carcinoma, Metastatic, Kidney                                 1 (13%)                                                         
      Sarcoma Stromal, Metastatic, Uterus                                                     1 (14%)                               
   Oral Mucosa                                        (1)          (1)          (1)                                                 
      Pharyngeal, Squamous Cell Papilloma              1 (100%)                                                                     
   Pancreas                                           (49)         (49)         (48)         (50)                                   
      Carcinoma, Metastatic, Kidney                                 1 (2%)                                                          
   Salivary Glands                                    (49)         (50)         (49)         (50)                                   
   Stomach, Forestomach                               (50)         (50)         (49)         (50)                                   
      Leiomyosarcoma                                                                          1 (2%)                                
   Stomach, Glandular                                 (50)         (49)         (49)         (50)                                   
   Tongue                                             (1)          (4)          (1)          (3)                                    
      Squamous Cell Carcinoma                                       1 (25%)                   1 (33%)                               
      Squamous Cell Papilloma                                       2 (50%)                   1 (33%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   2                                                               
NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (49)         (50)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (48)         (50)                                   
      Adenoma                                          2 (4%)                                 2 (4%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (48)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Complex                                      1 (2%)                                                          
      Pheochromocytoma Benign                          4 (8%)       5 (10%)      2 (4%)       5 (10%)                               
      Bilateral, Pheochromocytoma Benign                            2 (4%)       2 (4%)       2 (4%)                                
   Islets, Pancreatic                                 (49)         (48)         (48)         (50)                                   
      Adenoma                                          1 (2%)                    3 (6%)                                             
      Carcinoma                                                     1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (46)         (43)         (44)         (46)                                   
      Adenoma                                                                                 1 (2%)                                
   Pituitary Gland                                    (50)         (49)         (48)         (50)                                   
      Pars Distalis, Adenoma                          38 (76%)     35 (71%)     34 (71%)     35 (70%)                               
   Thyroid Gland                                      (49)         (49)         (47)         (48)                                   
      C-Cell, Adenoma                                  7 (14%)      5 (10%)      6 (13%)      5 (10%)                               
      C-Cell, Carcinoma                                1 (2%)       1 (2%)       2 (4%)                                             
      Follicular Cell, Adenoma                                                                1 (2%)                                
      Follicular Cell, Carcinoma                                    2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (44)         (45)         (46)         (45)                                   
      Adenoma                                          3 (7%)       2 (4%)       2 (4%)       7 (16%)                               
      Carcinoma                                        3 (7%)                    2 (4%)       1 (2%)                                
      Bilateral, Adenoma                               1 (2%)                                                                       
      Bilateral, Carcinoma                                                                    1 (2%)                                
   Ovary                                              (50)         (50)         (49)         (50)                                   
      Granulosa Cell Tumor Benign                                   1 (2%)       1 (2%)                                             
      Sertoli Cell Tumor Benign                                                               1 (2%)                                
   Uterus                                             (50)         (50)         (49)         (50)                                   
      Adenoma                                          1 (2%)                                                                       

                                                             Page   3                                                               
NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Rectum                                                                1 (2%)                                             
      Polyp Stromal                                    5 (10%)      9 (18%)      6 (12%)      2 (4%)                                
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Sarcoma Stromal                                                                         2 (4%)                                
      Schwannoma Malignant                             2 (4%)       1 (2%)                                                          
   Vagina                                                          (1)          (3)                                                 
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Rectum                                                                1 (33%)                                            
      Polyp                                                                      1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (48)         (48)         (50)                                   
   Lymph Node                                         (4)          (5)          (8)          (11)                                   
   Lymph Node, Bronchial                              (37)         (30)         (40)         (25)                                   
      Carcinoma, Metastatic, Thyroid Gland             1 (3%)                                                                       
      Histiocytic Sarcoma                                                                     1 (4%)                                
   Lymph Node, Mandibular                             (46)         (46)         (46)         (42)                                   
   Lymph Node, Mesenteric                             (50)         (50)         (49)         (50)                                   
      Carcinoma, Metastatic, Kidney                                 1 (2%)                                                          
   Lymph Node, Mediastinal                            (43)         (37)         (45)         (40)                                   
      Carcinoma, Metastatic, Kidney                                 1 (3%)                                                          
   Spleen                                             (49)         (49)         (49)         (50)                                   
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Sarcoma                                          1 (2%)                                                                       
   Thymus                                             (47)         (44)         (44)         (43)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (49)         (49)         (50)                                   
      Adenoma                                          1 (2%)                                                                       
      Carcinoma                                        7 (14%)      2 (4%)       2 (4%)       5 (10%)                               
      Carcinoma, Multiple                              2 (4%)                                 1 (2%)                                
      Fibroadenoma                                    17 (34%)     17 (35%)     19 (39%)     14 (28%)                               
      Fibroadenoma, Multiple                           2 (4%)       7 (14%)      6 (12%)      6 (12%)                               
   Skin                                               (50)         (50)         (48)         (50)                                   
      Keratoacanthoma                                  1 (2%)       2 (4%)                                                          
      Squamous Cell Papilloma                                                                 1 (2%)                                
      Subcutaneous Tissue, Fibroma                                               3 (6%)       2 (4%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   4                                                               
NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (49)         (50)                                   
      Fibroma                                          1 (2%)                                                                       
      Osteosarcoma                                                               2 (4%)       1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (49)         (50)                                   
      Astrocytoma Malignant                                         1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (49)         (49)                                   
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
   Lung                                               (50)         (50)         (49)         (50)                                   
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Mammary Gland                          1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Osteosarcoma, Metastatic, Bone                                             2 (4%)                                             
      Mediastinum, Osteosarcoma, Metastatic, Bone                                1 (2%)                                             
   Nose                                               (49)         (50)         (48)         (49)                                   
      Lateral Wall, Adenoma                                                      1 (2%)                                             
      Respiratory Epithelium, Adenoma                                                         1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (49)         (50)                                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Renal Tubule, Adenoma                                                                   2 (4%)                                
      Renal Tubule, Carcinoma                                       1 (2%)                                                          
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
   Urinary Bladder                                    (49)         (49)         (49)         (50)                                   
      Leiomyosarcoma, Metastatic, Intestine Large,                                                                                  
           Rectum                                                                1 (2%)                                             

                                                             Page   5                                                               
NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(49)        *(50)                                   
      Histiocytic Sarcoma                                           1 (2%)                    1 (2%)                                
      Leukemia Mononuclear                            21 (42%)     19 (38%)     18 (37%)     29 (58%)                               
      Lymphoma Malignant                                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page   6                                                               
NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          49          49          49                                       
     Total Primary Neoplasms                          127         119         120         131                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          47          46          43                                       
     Total Benign Neoplasms                            88          87          87          88                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              31          28          32          36                                       
     Total Malignant Neoplasms                         39          32          33          43                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           3           1                                       
     Total Metastatic Neoplasm                          3           5          10           1                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page   7                                                               
NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 

  Animals Initially in Study                          50           50           50           50                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                34           43           31           43                                     
    Natural Death                                      8            2           10            7                                     
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                 7            5            9                                                  

  Animals Examined Microscopically                    50           50           50           50                                     
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (49)         (50)         (48)         (47)                                   
   Intestine Large, Cecum                             (46)         (49)         (44)         (45)                                   
   Intestine Small, Duodenum                          (50)         (50)         (50)         (49)                                   
   Intestine Small, Jejunum                           (46)         (50)         (43)         (44)                                   
      Carcinoma                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (47)         (49)         (43)         (45)                                   
   Liver                                              (50)         (50)         (50)         (50)                                   
      Hepatocellular Adenoma                           1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                                                        2 (4%)                                             
   Mesentery                                          (11)         (13)         (9)          (26)                                   
   Oral Mucosa                                        (1)          (1)          (1)          (1)                                    
      Pharyngeal, Squamous Cell Papilloma                                                     1 (100%)                              
   Pancreas                                           (50)         (50)         (50)         (49)                                   
      Adenoma                                                       1 (2%)       1 (2%)                                             
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
   Salivary Glands                                    (47)         (50)         (49)         (49)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Forestomach                               (50)         (50)         (50)         (50)                                   
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)         (49)                                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   8                                                               
NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Cortex                                     (50)         (50)         (50)         (50)                                   
      Adenoma                                                       1 (2%)                                                          
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
      Bilateral, Adenoma                                                         1 (2%)                                             
   Adrenal Medulla                                    (50)         (50)         (50)         (50)                                   
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
      Pheochromocytoma Malignant                       1 (2%)                    2 (4%)       1 (2%)                                
      Pheochromocytoma Complex                                                   1 (2%)                                             
      Pheochromocytoma Benign                         11 (22%)     13 (26%)     12 (24%)      6 (12%)                               
      Bilateral, Pheochromocytoma Benign               8 (16%)     14 (28%)     10 (20%)     20 (40%)                               
   Islets, Pancreatic                                 (50)         (50)         (50)         (49)                                   
      Adenoma                                          3 (6%)                    2 (4%)                                             
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (49)         (45)         (50)         (49)                                   
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)         (48)         (50)                                   
      Pars Distalis, Adenoma                          36 (72%)     37 (74%)     39 (81%)     31 (62%)                               
   Thyroid Gland                                      (49)         (49)         (49)         (47)                                   
      C-Cell, Adenoma                                  5 (10%)      6 (12%)      5 (10%)                                            
      C-Cell, Carcinoma                                             1 (2%)       1 (2%)                                             
      Follicular Cell, Adenoma                                                   2 (4%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Peritoneum                                         (1)          (1)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)                                   
   Preputial Gland                                    (49)         (50)         (49)         (50)                                   
      Adenoma                                          2 (4%)       3 (6%)       2 (4%)       2 (4%)                                
      Carcinoma                                        3 (6%)       2 (4%)       5 (10%)      2 (4%)                                
      Schwannoma Malignant                                                                    1 (2%)                                
      Bilateral, Carcinoma                                                                    1 (2%)                                
   Prostate                                           (50)         (50)         (50)         (50)                                   
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
   Seminal Vesicle                                    (49)         (49)         (46)         (47)                                   
      Adenoma                                                       1 (2%)                                                          
   Testes                                             (50)         (50)         (50)         (50)                                   
      Bilateral, Interstitial Cell, Adenoma           28 (56%)     27 (54%)     27 (54%)     18 (36%)                               
      Interstitial Cell, Adenoma                       7 (14%)      8 (16%)     10 (20%)     14 (28%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page   9                                                               
NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (49)                                   
   Lymph Node                                         (10)         (8)          (10)         (12)                                   
   Lymph Node, Bronchial                              (39)         (28)         (33)         (22)                                   
      Carcinoma, Metastatic, Kidney                                              1 (3%)                                             
   Lymph Node, Mandibular                             (44)         (42)         (48)         (46)                                   
   Lymph Node, Mesenteric                             (48)         (50)         (50)         (45)                                   
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
   Lymph Node, Mediastinal                            (45)         (47)         (46)         (44)                                   
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Thymus                                             (43)         (40)         (41)         (38)                                   
      Thymoma Benign                                                                          1 (3%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (30)         (25)         (29)         (27)                                   
      Carcinoma                                                                  2 (7%)                                             
      Carcinoma, Multiple                              1 (3%)                                                                       
      Fibroadenoma                                     2 (7%)       1 (4%)       5 (17%)                                            
   Skin                                               (50)         (50)         (50)         (50)                                   
      Basal Cell Adenoma                                            1 (2%)       3 (6%)                                             
      Basal Cell Carcinoma                             2 (4%)                    1 (2%)                                             
      Keratoacanthoma                                  5 (10%)      1 (2%)       7 (14%)      4 (8%)                                
      Squamous Cell Carcinoma                                                    1 (2%)                                             
      Squamous Cell Papilloma                                       2 (4%)                                                          
      Sebaceous Gland, Carcinoma                       2 (4%)                                                                       
      Subcutaneous Tissue, Fibroma                     4 (8%)       2 (4%)       5 (10%)      1 (2%)                                
      Subcutaneous Tissue, Fibroma, Multiple                                     1 (2%)                                             
      Subcutaneous Tissue, Histiocytic Sarcoma                                   1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant        2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Osteoma                                          1 (2%)                                                                       
      Turbinate, Osteosarcoma                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    

                                                             Page  10                                                               
NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)                                   
      Meningioma Malignant                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Alveolar/Bronchiolar Adenoma                                  2 (4%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Carcinoma, Metastatic, Kidney                                              1 (2%)                                             
      Carcinoma, Metastatic, Preputial Gland                                     1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Medulla                                                        1 (2%)                                             
   Nose                                               (50)         (50)         (50)         (50)                                   
      Lateral Wall, Adenoma                                         1 (2%)                                                          
      Respiratory Epithelium, Adenoma                                            1 (2%)                                             
      Respiratory Epithelium, Carcinoma                                                       1 (2%)                                
      Respiratory Epithelium, Squamous Cell                                                                                         
          Carcinoma                                                                           3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                       (1)          (3)                                    
      Adenoma                                                                    1 (100%)                                           
      Carcinoma                                        1 (100%)                               3 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Lipoma                                                        1 (2%)                                                          
      Nephroblastoma                                                             1 (2%)                                             
      Stromal Nephroma                                                           1 (2%)                                             
      Renal Tubule, Adenoma                            1 (2%)       1 (2%)       2 (4%)                                             
      Transitional Epithelium, Carcinoma                                         1 (2%)                                             
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   

                                                             Page  11                                                               
NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   

   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)                                   
      Histiocytic Sarcoma                                                        2 (4%)                                             
      Leukemia Mononuclear                            29 (58%)     31 (62%)     28 (56%)     15 (30%)                               
      Mesothelioma Malignant                           3 (6%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________

                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 

                                                             Page  12                                                               
NTP Experiment-Test: 05201-05  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          FURFURYL ALCOHOL                                     Date: 09/25/97  
Route: RESPIRATORY EXPOSURE WHOLE BODY                                                                            Time: 15:12:30  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      2.0 PPM      8.0 PPM      32.0 PPM                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          50          50          50                                       
     Total Primary Neoplasms                          161         166         189         125                                       
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          50          49          47                                       
     Total Benign Neoplasms                           115         126         139          98                                       
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35          35          34          26                                       
     Total Malignant Neoplasms                         46          40          50          27                                       
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                                      4                                                   
     Total Metastatic Neoplasm                                                 11                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    

____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              

                                                             Page  13                                                               
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